| Wednesday, February 20 |
| Former White Sox Dixie Leverett dies in Beaverton, OR at the age of 63. |
| Sunday, March 10 |
| Former White Sox Erskine Mayer dies in Los Angeles, CA at the age of 69. |
| Sunday, March 31 |
| Former White Sox Bill Meyer dies in Knoxville, TN at the age of 66. |
| Sunday, April 7 |
| Former White Sox Jim Scott dies in Jacumba, CA at the age of 69. |
| Monday, April 15 |
| » Major-league debuts: Neil Chrisley (Senators) |
| Tuesday, April 16 |
| » Defeated Indians (0-1), 3-2 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Billy Pierce vs Herb Score | First | -- |
| » Major-league debuts: Roger Maris and Larry Raines (Indians) Jim Landis (White Sox) |
| Thursday, April 18 |
| » Defeated Athletics (2-1), 6-2 | Comiskey Park I (1-0) | 2-0 | Won 2 |
| » Starters: Alex Kellner vs Jack Harshman | First | -- |
| Saturday, April 20 |
| » Defeated Athletics (2-2), 11-7 | Comiskey Park I (2-0) | 3-0 | Won 3 |
| » Starters: Gene Host vs Dick Donovan | First | -- |
| Sunday, April 21 |
| » Defeated Athletics (2-3), 1-0 | Comiskey Park I (3-0) | 4-0 | Won 4 |
| » Starters: Tom Morgan vs Jim Wilson | First | -- |
| Monday, April 22 |
| Future White Sox Dave Schmidt is born in Niles, MI. Former White Sox Joe Benz dies in Chicago, IL at the age of 72. |
| Tuesday, April 23 |
| » Lost to Indians (2-3), 5-0 | Comiskey Park I (3-1) | 4-1 | |
| » Starters: Herb Score vs Billy Pierce | First | -- |
| Thursday, April 25 |
| » Defeated Tigers (2-6), 9-4 | Comiskey Park I (4-1) | 5-1 | |
| » Starters: Billy Hoeft vs Jack Harshman | First | -- |
| Friday, April 26 |
| » Defeated Athletics (5-5), 4-3 | Municipal Stadium (1-0) | 6-1 | Won 2 |
| » Starters: Billy Pierce vs Tom Morgan | First | -- |
| Saturday, April 27 |
| » Lost to Athletics (6-5), 3-2 | Municipal Stadium (1-1) | 6-2 | |
| » Starters: Dick Donovan vs Alex Kellner | First | -- |
| Sunday, April 28 |
| » Defeated Athletics (6-6), 5-3 | Municipal Stadium (2-1) | 7-2 | |
| » Starters: Jim Wilson vs Rip Coleman | First | -- |
| Tuesday, April 30 |
| » Defeated Orioles (6-8), 6-1 | Comiskey Park I (5-1) | 8-2 | Won 2 |
| » Starters: Ray Moore vs Billy Pierce | First | -- |
| Wednesday, May 1 |
| » Defeated Orioles (6-9), 9-3 | Comiskey Park I (6-1) | 9-2 | Won 3 |
| » Starters: Billy Loes vs Jack Harshman | First | -- |
| Thursday, May 2 |
| » Defeated Senators (5-12), 6-1 | Comiskey Park I (7-1) | 10-2 | Won 4 |
| » Starters: Chuck Stobbs vs Dick Donovan | First | -- |
| Friday, May 3 |
| » Defeated Senators (5-13), 11-6 | Comiskey Park I (8-1) | 11-2 | Won 5 |
| » Starters: Russ Kemmerer vs Bob Keegan | First | -- |
| Saturday, May 4 |
| » Lost to Yankees (10-5), 3-2 | Comiskey Park I (8-2) | 11-3 | |
| » Starters: Whitey Ford vs Jim Wilson | First | -- |
| Sunday, May 5 |
| » Lost to Yankees (11-5), 4-2 | Comiskey Park I (8-3) | 11-4 | Lost 2 |
| » Starters: Bobby Shantz vs Billy Pierce | Second | ½ out |
| » Lost to Yankees (12-5), 3-0 | Comiskey Park I (8-4) | 11-5 | Lost 3 |
| » Starters: Johnny Kucks vs Jack Harshman | Second | ½ out |
| Tuesday, May 7 |
| » Lost to Red Sox (11-8), 4-3 | Comiskey Park I (8-5) | 11-6 | Lost 4 |
| » Starters: Tom Brewer vs Dick Donovan | Second | ½ out |
| Wednesday, May 8 |
| » Lost to Red Sox (12-8), 4-1 | Comiskey Park I (8-6) | 11-7 | Lost 5 |
| » Starters: Frank Sullivan vs Bob Keegan | Second | ½ out |
| Thursday, May 9 |
| » Defeated Red Sox (12-9), 2-0 | Comiskey Park I (9-6) | 12-7 | |
| » Starters: Dean Stone vs Jim Wilson | First | -- |
| Friday, May 10 |
| » Defeated Tigers (11-12), 6-4 | Tiger Stadium (1-0) | 13-7 | Won 2 |
| » Starters: Billy Pierce vs Don Lee | First | -- |
| Sunday, May 12 |
| » Defeated Tigers (11-13), 5-4 | Tiger Stadium (2-0) | 14-7 | Won 3 |
| » Starters: Jack Harshman vs Paul Foytack | First | -- |
| Wednesday, May 15 |
| » Defeated Senators (8-20), 5-0 | Griffith Stadium (1-0) | 15-7 | Won 4 |
| » Starters: Jim Wilson vs Chuck Stobbs | First | -- |
| Thursday, May 16 |
| » Defeated Senators (8-21), 8-3 | Griffith Stadium (2-0) | 16-7 | Won 5 |
| » Starters: Billy Pierce vs Pedro Ramos | First | -- |
| Friday, May 17 |
| » Defeated Orioles (9-17), 3-2 | Memorial Stadium (1-0) | 17-7 | Won 6 |
| » Starters: Dick Donovan vs Art Ceccarelli | First | -- |
| Saturday, May 18 |
| » Tied Orioles, 4-4 | Memorial Stadium (1-0) | 17-7 | |
| » Starters: Jack Harshman vs Bill Wight | First | -- |
| Sunday, May 19 |
| » Defeated Red Sox (15-15), 6-2 | Fenway Park (1-0) | 18-7 | Won 7 |
| » Starters: Bill Fischer vs Frank Sullivan | First | -- |
| Tuesday, May 21 |
| » Defeated Yankees (17-11), 3-1 | Yankee Stadium (1-0) | 19-7 | Won 8 |
| » Starters: Billy Pierce vs Whitey Ford | First | -- |
| Wednesday, May 22 |
| » Defeated Yankees (17-12), 8-4 | Yankee Stadium (2-0) | 20-7 | Won 9 |
| » Starters: Jim Wilson vs Johnny Kucks | First | -- |
| Friday, May 24 |
| » Lost to Indians (19-11), 4-3 | Cleveland Stadium (1-1) | 20-8 | |
| » Starters: Jack Harshman vs Bob Lemon | First | -- |
| Saturday, May 25 |
| » Defeated Indians (19-12), 4-0 | Cleveland Stadium (2-1) | 21-8 | |
| » Starters: Dick Donovan vs Early Wynn | First | -- |
| Sunday, May 26 |
| » Defeated Indians (19-13), 1-0 | Cleveland Stadium (3-1) | 22-8 | Won 2 |
| » Starters: Billy Pierce vs Bud Daley | First | -- |
| » Lost to Indians (20-13), 4-3 | Cleveland Stadium (3-2) | 22-9 | |
| » Starters: Jack Harshman vs Dick Tomanek | First | -- |
| Monday, May 27 |
| » Lost to Athletics (17-19), 7-1 | Comiskey Park I (9-7) | 22-10 | Lost 2 |
| » Starters: Alex Kellner vs Jim Wilson | First | -- |
| Tuesday, May 28 |
| » Defeated Athletics (17-20), 3-1 | Comiskey Park I (10-7) | 23-10 | |
| » Starters: Rip Coleman vs Bill Fischer | First | -- |
| Wednesday, May 29 |
| » Lost to Indians (22-14), 8-4 | Comiskey Park I (10-8) | 23-11 | |
| » Starters: Early Wynn vs Jack Harshman | First | -- |
| Thursday, May 30 |
| » Defeated Indians (22-15), 6-4 | Comiskey Park I (11-8) | 24-11 | |
| » Starters: Bud Daley vs Dick Donovan | First | -- |
| » Defeated Indians (22-16), 2-1 | Comiskey Park I (12-8) | 25-11 | Won 2 |
| » Starters: Mike Garcia vs Billy Pierce | First | -- |
| Friday, May 31 |
| » Defeated Tigers (21-20), 6-0 | Comiskey Park I (13-8) | 26-11 | Won 3 |
| » Starters: Frank Lary vs Bob Keegan | First | -- |
| Saturday, June 1 |
| » Defeated Tigers (21-21), 12-4 | Comiskey Park I (14-8) | 27-11 | Won 4 |
| » Starters: Billy Hoeft vs Jim Wilson | First | -- |
| Sunday, June 2 |
| » Lost to Tigers (22-21), 3-1 | Comiskey Park I (14-9) | 27-12 | |
| » Starters: Jim Bunning vs Bill Fischer | First | -- |
| » Defeated Tigers (22-22), 4-1 | Comiskey Park I (15-9) | 28-12 | |
| » Starters: Paul Foytack vs Jack Harshman | First | -- |
| Tuesday, June 4 |
| » Defeated Red Sox (23-22), 1-0 | Comiskey Park I (16-9) | 29-12 | Won 2 |
| » Starters: Dean Stone vs Billy Pierce | First | -- |
| Future White Sox Tony Pena is born in Monte Cristi, D.R. |
| Wednesday, June 5 |
| » Defeated Red Sox (23-23), 6-2 | Comiskey Park I (17-9) | 30-12 | Won 3 |
| » Starters: Tom Brewer vs Dick Donovan | First | -- |
| Thursday, June 6 |
| » Defeated Red Sox (23-24), 3-2 | Comiskey Park I (18-9) | 31-12 | Won 4 |
| » Starters: Dave Sisler vs Jim Wilson | First | -- |
| Friday, June 7 |
| » Lost to Orioles (20-26), 3-2 | Comiskey Park I (18-10) | 31-13 | |
| » Starters: Art Ceccarelli vs Jack Harshman | First | -- |
| Saturday, June 8 |
| » Defeated Orioles (20-27), 2-0 | Comiskey Park I (19-10) | 32-13 | |
| » Starters: Bill Wight vs Billy Pierce | First | -- |
| Sunday, June 9 |
| » Lost to Orioles (21-27), 7-5 | Comiskey Park I (19-11) | 32-14 | |
| » Starters: Ray Moore vs Bill Fischer | First | -- |
| » Lost to Orioles (22-27), 5-0 | Comiskey Park I (19-12) | 32-15 | Lost 2 |
| » Starters: Billy O'Dell vs Dick Donovan | First | -- |
| Tuesday, June 11 |
| » Lost to Yankees (29-21), 3-2 | Comiskey Park I (19-13) | 32-16 | Lost 3 |
| » Starters: Bobby Shantz vs Jim Wilson | First | -- |
| Wednesday, June 12 |
| » Defeated Yankees (29-22), 7-6 | Comiskey Park I (20-13) | 33-16 | |
| » Starters: Johnny Kucks vs Jack Harshman | First | -- |
| Thursday, June 13 |
| » Lost to Yankees (30-22), 4-3 | Comiskey Park I (20-14) | 33-17 | |
| » Starters: Art Ditmar vs Billy Pierce | First | -- |
| Friday, June 14 |
| » Defeated Senators (19-38), 10-4 | Comiskey Park I (21-14) | 34-17 | |
| » Starters: Chuck Stobbs vs Dick Donovan | First | -- |
| Saturday, June 15 |
| » Lost to Senators (20-38), 9-1 | Comiskey Park I (21-15) | 34-18 | |
| » Starters: Russ Kemmerer vs Bill Fischer | First | -- |
| Sunday, June 16 |
| » Defeated Senators (20-39), 4-2 | Comiskey Park I (22-15) | 35-18 | |
| » Starters: Pedro Ramos vs Jim Wilson | First | -- |
| » Defeated Senators (20-40), 8-6 | Comiskey Park I (23-15) | 36-18 | Won 2 |
| » Starters: Tex Clevenger vs Jack Harshman | First | -- |
| Future White Sox Salome Barojas is born in Cordoba, Mexico. |
| Tuesday, June 18 |
| » Lost to Orioles (25-32), 2-1 | Memorial Stadium (1-1) | 36-19 | |
| » Starters: Billy Pierce vs Ray Moore | First | -- |
| Wednesday, June 19 |
| » Defeated Orioles (25-33), 3-1 | Memorial Stadium (2-1) | 37-19 | |
| » Starters: Bob Keegan vs Art Ceccarelli | First | -- |
| Thursday, June 20 |
| » Lost to Orioles (26-33), 4-1 | Memorial Stadium (2-2) | 37-20 | |
| » Starters: Bill Fischer vs Billy Loes | First | -- |
| Friday, June 21 |
| » Lost to Yankees (37-22), 4-2 | Yankee Stadium (2-1) | 37-21 | Lost 2 |
| » Starters: Jim Wilson vs Johnny Kucks | First | -- |
| Saturday, June 22 |
| » Lost to Yankees (38-22), 6-5 | Yankee Stadium (2-2) | 37-22 | Lost 3 |
| » Starters: Jack Harshman vs Art Ditmar | Second | ½ out |
| Sunday, June 23 |
| » Lost to Yankees (39-22), 9-2 | Yankee Stadium (2-3) | 37-23 | Lost 4 |
| » Starters: Billy Pierce vs Bobby Shantz | Second | ½ out |
| » Defeated Yankees (39-23), 4-3 | Yankee Stadium (3-3) | 38-23 | |
| » Starters: Dick Donovan vs Al Cicotte | Second | ½ out |
| Tuesday, June 25 |
| » Defeated Red Sox (33-32), 2-1 | Fenway Park (2-0) | 39-23 | Won 2 |
| » Starters: Bob Keegan vs Dave Sisler | First | -- |
| Wednesday, June 26 |
| » Defeated Red Sox (33-33), 7-5 | Fenway Park (3-0) | 40-23 | Won 3 |
| » Starters: Jim Wilson vs Willard Nixon | First | -- |
| Thursday, June 27 |
| » Lost to Red Sox (34-33), 8-3 | Fenway Park (3-1) | 40-24 | |
| » Starters: Jack Harshman vs Frank Sullivan | First | -- |
| » Lost to Red Sox (35-33), 9-2 | Fenway Park (3-2) | 40-25 | Lost 2 |
| » Starters: Billy Pierce vs Mike Fornieles | First | -- |
| Friday, June 28 |
| » Defeated Senators (23-48), 4-3 | Griffith Stadium (3-0) | 41-25 | |
| » Starters: Dick Donovan vs Russ Kemmerer | First | -- |
| Saturday, June 29 |
| » Defeated Senators (23-49), 7-1 | Griffith Stadium (4-0) | 42-25 | Won 2 |
| » Starters: Jack Harshman vs Jim Heise | First | -- |
| Sunday, June 30 |
| » Defeated Senators (23-50), 7-6 | Griffith Stadium (5-0) | 43-25 | Won 3 |
| » Starters: Bob Keegan vs Chuck Stobbs | Second | 1 out |
| » Lost to Senators (24-50), 11-9 | Griffith Stadium (5-1) | 43-26 | |
| » Starters: Jim Derrington vs Pedro Ramos | Second | 1 out |
| Monday, July 1 |
| » Lost to Tigers (36-35), 5-2 | Tiger Stadium (2-1) | 43-27 | Lost 2 |
| » Starters: Jim Wilson vs Jim Bunning | Second | 2 out |
| Tuesday, July 2 |
| » Defeated Tigers (36-36), 4-2 | Tiger Stadium (3-1) | 44-27 | |
| » Starters: Billy Pierce vs Frank Lary | Second | 2 out |
| Wednesday, July 3 |
| » Lost to Athletics (27-44), 5-0 | Municipal Stadium (2-2) | 44-28 | |
| » Starters: Dick Donovan vs Virgil Trucks | Second | 3 out |
| Thursday, July 4 |
| » Lost to Athletics (28-44), 5-4 | Municipal Stadium (2-3) | 44-29 | Lost 2 |
| » Starters: Jack Harshman vs Alex Kellner | Second | 3 out |
| » Defeated Athletics (28-45), 8-3 | Municipal Stadium (3-3) | 45-29 | |
| » Starters: Bob Keegan vs Ned Garver | Second | 3 out |
| Friday, July 5 |
| » Defeated Indians (39-35), 14-4 | Comiskey Park I (24-15) | 46-29 | Won 2 |
| » Starters: Stan Pitula vs Jim Wilson | Second | 3 out |
| Saturday, July 6 |
| » Defeated Indians (39-36), 5-1 | Comiskey Park I (25-15) | 47-29 | Won 3 |
| » Starters: Bob Lemon vs Billy Pierce | Second | 3 out |
| Sunday, July 7 |
| » Defeated Indians (39-37), 9-8 | Comiskey Park I (26-15) | 48-29 | Won 4 |
| » Starters: Don Mossi vs Dick Donovan | Second | 2½ out |
| » Defeated Indians (39-38), 7-2 | Comiskey Park I (27-15) | 49-29 | Won 5 |
| » Starters: Early Wynn vs Jack Harshman | Second | 2½ out |
| Thursday, July 11 |
| » Lost to Senators (26-56), 6-5 | Comiskey Park I (27-16) | 49-30 | |
| » Starters: Pedro Ramos vs Jim Wilson | Second | 3½ out |
| Saturday, July 13 |
| » Defeated Senators (26-57), 7-4 | Comiskey Park I (28-16) | 50-30 | |
| » Starters: Chuck Stobbs vs Jack Harshman | Second | 3 out |
| Sunday, July 14 |
| » Defeated Yankees (53-28), 3-1 | Comiskey Park I (29-16) | 51-30 | Won 2 |
| » Starters: Bobby Shantz vs Billy Pierce | Second | 3 out |
| » Lost to Yankees (54-28), 6-4 | Comiskey Park I (29-17) | 51-31 | |
| » Starters: Whitey Ford vs Dick Donovan | Second | 3 out |
| Tuesday, July 16 |
| » Lost to Orioles (40-43), 3-1 | Comiskey Park I (29-18) | 51-32 | Lost 2 |
| » Starters: Ray Moore vs Jim Wilson | Second | 4 out |
| Wednesday, July 17 |
| » Defeated Orioles (40-44), 3-1 | Comiskey Park I (30-18) | 52-32 | |
| » Starters: Bill Wight vs Bob Keegan | Second | 4 out |
| Thursday, July 18 |
| » Lost to Orioles (41-44), 6-2 | Comiskey Park I (30-19) | 52-33 | |
| » Starters: Billy O'Dell vs Jack Harshman | Second | 5 out |
| Friday, July 19 |
| » Lost to Red Sox (47-41), 5-2 | Comiskey Park I (30-20) | 52-34 | Lost 2 |
| » Starters: Willard Nixon vs Billy Pierce | Second | 6 out |
| Saturday, July 20 |
| » Defeated Red Sox (47-42), 4-0 | Comiskey Park I (31-20) | 53-34 | |
| » Starters: Dave Sisler vs Dick Donovan | Second | 5 out |
| Sunday, July 21 |
| » Defeated Red Sox (47-43), 3-0 | Comiskey Park I (32-20) | 54-34 | Won 2 |
| » Starters: Mike Fornieles vs Jim Wilson | Second | 4½ out |
| Tuesday, July 23 |
| » Lost to Yankees (60-30), 10-6 | Yankee Stadium (3-4) | 54-35 | |
| » Starters: Bob Keegan vs Don Larsen | Second | 5½ out |
| Wednesday, July 24 |
| » Defeated Yankees (60-31), 7-2 | Yankee Stadium (4-4) | 55-35 | |
| » Starters: Billy Pierce vs Whitey Ford | Second | 4½ out |
| Thursday, July 25 |
| » Defeated Yankees (60-32), 6-2 | Yankee Stadium (5-4) | 56-35 | Won 2 |
| » Starters: Dick Donovan vs Bobby Shantz | Second | 3½ out |
| Friday, July 26 |
| » Lost to Orioles (45-48), 5-2 | Memorial Stadium (2-3) | 56-36 | |
| » Starters: Jack Harshman vs Ray Moore | Second | 3 out |
| » Defeated Orioles (45-49), 1-0 | Memorial Stadium (3-3) | 57-36 | |
| » Starters: Jim Wilson vs Ken Lehman | Second | 3 out |
| Saturday, July 27 |
| » Lost to Orioles (46-49), 5-2 | Memorial Stadium (3-4) | 57-37 | |
| » Starters: Bob Keegan vs Bill Wight | Second | 4 out |
| Sunday, July 28 |
| » Defeated Orioles (46-50), 4-3 | Memorial Stadium (4-4) | 58-37 | |
| » Starters: Jack Harshman vs Billy O'Dell | Second | 3½ out |
| Monday, July 29 |
| » Defeated Orioles (46-51), 5-0 | Memorial Stadium (5-4) | 59-37 | Won 2 |
| » Starters: Billy Pierce vs Hal Brown | Second | 3 out |
| Tuesday, July 30 |
| » Defeated Senators (35-65), 7-1 | Griffith Stadium (6-1) | 60-37 | Won 3 |
| » Starters: Dick Donovan vs Russ Kemmerer | Second | 3 out |
| Future White Sox Steve Trout is born in Detroit, MI. |
| Wednesday, July 31 |
| » Defeated Senators (35-66), 6-5 | Griffith Stadium (7-1) | 61-37 | Won 4 |
| » Starters: Bob Keegan vs Pedro Ramos | Second | 3½ out |
| Thursday, August 1 |
| » Lost to Senators (36-66), 5-4 | Griffith Stadium (7-2) | 61-38 | |
| » Starters: Jack Harshman vs Chuck Stobbs | Second | 4 out |
| Friday, August 2 |
| » Lost to Red Sox (55-46), 5-4 | Fenway Park (3-3) | 61-39 | Lost 2 |
| » Starters: Jim Wilson vs Frank Sullivan | Second | 5 out |
| Saturday, August 3 |
| » Lost to Red Sox (56-46), 8-7 | Fenway Park (3-4) | 61-40 | Lost 3 |
| » Starters: Billy Pierce vs Tom Brewer | Second | 6 out |
| Sunday, August 4 |
| » Defeated Red Sox (56-47), 11-6 | Fenway Park (4-4) | 62-40 | |
| » Starters: Dick Donovan vs Bob Porterfield | Second | 6½ out |
| Tuesday, August 6 |
| » Lost to Athletics (37-67), 3-2 | Comiskey Park I (32-21) | 62-41 | |
| » Starters: Alex Kellner vs Bob Keegan | Second | 7 out |
| Wednesday, August 7 |
| » Defeated Athletics (37-68), 7-0 | Comiskey Park I (33-21) | 63-41 | |
| » Starters: Mickey McDermott vs Jim Wilson | Second | 6 out |
| Thursday, August 8 |
| » Defeated Athletics (37-69), 7-4 | Comiskey Park I (34-21) | 64-41 | Won 2 |
| » Starters: Rip Coleman vs Billy Pierce | Second | 5 out |
| Friday, August 9 |
| » Defeated Tigers (51-55), 5-4 | Comiskey Park I (35-21) | 65-41 | Won 3 |
| » Starters: Paul Foytack vs Dick Donovan | Second | 4 out |
| Saturday, August 10 |
| » Lost to Tigers (52-55), 6-4 | Comiskey Park I (35-22) | 65-42 | |
| » Starters: Frank Lary vs Jim Derrington | Second | 5 out |
| Sunday, August 11 |
| » Lost to Tigers (53-55), 8-5 | Comiskey Park I (35-23) | 65-43 | Lost 2 |
| » Starters: Jim Bunning vs Bob Keegan | Second | 5½ out |
| » Defeated Tigers (53-56), 11-2 | Comiskey Park I (36-23) | 66-43 | |
| » Starters: Billy Hoeft vs Jim Wilson | Second | 5½ out |
| » Major-league debuts: Bob Shaw (Tigers) |
| Tuesday, August 13 |
| » Defeated Indians (53-59), 10-5 | Cleveland Stadium (4-2) | 67-43 | Won 2 |
| » Starters: Billy Pierce vs Ray Narleski | Second | 5½ out |
| Wednesday, August 14 |
| » Defeated Indians (53-60), 8-3 | Cleveland Stadium (5-2) | 68-43 | Won 3 |
| » Starters: Dick Donovan vs Early Wynn | Second | 4½ out |
| Thursday, August 15 |
| » Lost to Indians (54-60), 5-4 | Cleveland Stadium (5-3) | 68-44 | |
| » Starters: Jack Harshman vs Don Mossi | Second | 5½ out |
| Friday, August 16 |
| » Lost to Tigers (56-58), 6-2 | Tiger Stadium (3-2) | 68-45 | Lost 2 |
| » Starters: Jim Wilson vs Billy Hoeft | Second | 5½ out |
| Saturday, August 17 |
| » Lost to Tigers (57-58), 9-8 | Tiger Stadium (3-3) | 68-46 | Lost 3 |
| » Starters: Jim Derrington vs Harry Byrd | Second | 6½ out |
| Sunday, August 18 |
| » Lost to Tigers (58-58), 5-1 | Tiger Stadium (3-4) | 68-47 | Lost 4 |
| » Starters: Billy Pierce vs Frank Lary | Second | 7½ out |
| » Defeated Tigers (58-59), 4-1 | Tiger Stadium (4-4) | 69-47 | |
| » Starters: Dick Donovan vs Duke Maas | Second | 7½ out |
| Tuesday, August 20 |
| » Lost to Senators (46-72), 5-4 | Comiskey Park I (36-24) | 69-48 | |
| » Starters: Dick Hyde vs Jim Wilson | Second | 7 out |
| » Defeated Senators (46-73), 6-0 | Comiskey Park I (37-24) | 70-48 | |
| » Starters: Chuck Stobbs vs Bob Keegan | Second | 7 out |
| Wednesday, August 21 |
| » Defeated Senators (46-74), 12-6 | Comiskey Park I (38-24) | 71-48 | Won 2 |
| » Starters: Russ Kemmerer vs Jim Derrington | Second | 6 out |
| Friday, August 23 |
| » Defeated Red Sox (63-57), 4-1 | Comiskey Park I (39-24) | 72-48 | Won 3 |
| » Starters: Frank Sullivan vs Billy Pierce | Second | 5½ out |
| Saturday, August 24 |
| » Defeated Red Sox (63-58), 7-1 | Comiskey Park I (40-24) | 73-48 | Won 4 |
| » Starters: Ike Delock vs Dick Donovan | Second | 5½ out |
| Sunday, August 25 |
| » Defeated Orioles (59-62), 6-2 | Comiskey Park I (41-24) | 74-48 | Won 5 |
| » Starters: Art Ceccarelli vs Bob Keegan | Second | 4 out |
| » Defeated Orioles (59-63), 3-0 | Comiskey Park I (42-24) | 75-48 | Won 6 |
| » Starters: Bill Wight vs Jack Harshman | Second | 4 out |
| » Major-league debuts: Lenny Green (Orioles) |
| Tuesday, August 27 |
| » Lost to Yankees (80-45), 12-6 | Comiskey Park I (42-25) | 75-49 | |
| » Starters: Art Ditmar vs Jim Wilson | Second | 4½ out |
| Wednesday, August 28 |
| » Lost to Yankees (81-45), 5-4 | Comiskey Park I (42-26) | 75-50 | Lost 2 |
| » Starters: Don Larsen vs Billy Pierce | Second | 5½ out |
| Thursday, August 29 |
| » Lost to Yankees (82-45), 2-1 | Comiskey Park I (42-27) | 75-51 | Lost 3 |
| » Starters: Tom Sturdivant vs Dick Donovan | Second | 6½ out |
| Friday, August 30 |
| » Lost to Athletics (50-78), 3-1 | Municipal Stadium (3-4) | 75-52 | Lost 4 |
| » Starters: Bob Keegan vs Alex Kellner | Second | 6½ out |
| Saturday, August 31 |
| » Defeated Athletics (50-79), 8-3 | Municipal Stadium (4-4) | 76-52 | |
| » Starters: Jim Wilson vs Tom Gorman | Second | 5½ out |
| Sunday, September 1 |
| » Defeated Athletics (50-80), 5-0 | Municipal Stadium (5-4) | 77-52 | Won 2 |
| » Starters: Bill Fischer vs Jack Urban | Second | 5½ out |
| Monday, September 2 |
| » Defeated Tigers (65-66), 8-2 | Tiger Stadium (5-4) | 78-52 | Won 3 |
| » Starters: Billy Pierce vs Duke Maas | Second | 4½ out |
| » Lost to Tigers (66-66), 5-4 | Tiger Stadium (5-5) | 78-53 | |
| » Starters: Dick Donovan vs Frank Lary | Second | 4½ out |
| Tuesday, September 3 |
| » Lost to Tigers (67-66), 3-2 | Tiger Stadium (5-6) | 78-54 | Lost 2 |
| » Starters: Bob Keegan vs Billy Hoeft | Second | 5½ out |
| Friday, September 6 |
| » Defeated Athletics (50-83), 4-3 | Comiskey Park I (43-27) | 79-54 | |
| » Starters: Alex Kellner vs Jim Wilson | Second | 4½ out |
| Saturday, September 7 |
| » Defeated Athletics (50-84), 8-2 | Comiskey Park I (44-27) | 80-54 | Won 2 |
| » Starters: Arnie Portocarrero vs Billy Pierce | Second | 4½ out |
| Sunday, September 8 |
| » Lost to Athletics (51-84), 3-2 | Comiskey Park I (44-28) | 80-55 | |
| » Starters: Jack Urban vs Dick Donovan | Second | 5½ out |
| Tuesday, September 10 |
| » Lost to Red Sox (75-62), 7-4 | Fenway Park (4-5) | 80-56 | Lost 2 |
| » Starters: Bob Keegan vs Tom Brewer | Second | 6 out |
| » Major-league debuts: Barry Latman (White Sox) |
| Wednesday, September 11 |
| » Defeated Red Sox (75-63), 4-1 | Fenway Park (5-5) | 81-56 | |
| » Starters: Bill Fischer vs Willard Nixon | Second | 5½ out |
| Thursday, September 12 |
| » Defeated Red Sox (75-64), 7-1 | Fenway Park (6-5) | 82-56 | Won 2 |
| » Starters: Jim Wilson vs Frank Sullivan | Second | 5 out |
| Friday, September 13 |
| » Lost to Yankees (89-52), 7-1 | Yankee Stadium (5-5) | 82-57 | |
| » Starters: Billy Pierce vs Whitey Ford | Second | 6 out |
| Saturday, September 14 |
| » Defeated Yankees (89-53), 5-2 | Yankee Stadium (6-5) | 83-57 | |
| » Starters: Dick Donovan vs Tom Sturdivant | Second | 5 out |
| Future White Sox Jerry Don Gleaton is born in Brownwood, TX. |
| Sunday, September 15 |
| » Defeated Senators (54-88), 3-1 | Griffith Stadium (8-2) | 84-57 | Won 2 |
| » Starters: Bob Keegan vs Tex Clevenger | Second | 5½ out |
| Tuesday, September 17 |
| » Lost to Orioles (70-73), 7-5 | Memorial Stadium (5-5) | 84-58 | |
| » Starters: Billy Pierce vs Hal Brown | Second | 6½ out |
| Wednesday, September 18 |
| » Defeated Orioles (70-74), 7-5 | Memorial Stadium (6-5) | 85-58 | |
| » Starters: Jim Wilson vs Don Ferrarese | Second | 6½ out |
| Thursday, September 19 |
| » Defeated Senators (54-91), 7-3 | Griffith Stadium (9-2) | 86-58 | Won 2 |
| » Starters: Bill Fischer vs Chuck Stobbs | Second | 6 out |
| Friday, September 20 |
| » Lost to Indians (71-74), 3-2 | Cleveland Stadium (5-4) | 86-59 | |
| » Starters: Dick Donovan vs Don Mossi | Second | 7 out |
| Saturday, September 21 |
| » Defeated Indians (71-75), 7-6 | Cleveland Stadium (6-4) | 87-59 | |
| » Starters: Barry Latman vs Early Wynn | Second | 6 out |
| » Major-league debuts: Don Rudolph (White Sox) |
| Sunday, September 22 |
| » Defeated Indians (71-76), 9-5 | Cleveland Stadium (7-4) | 88-59 | Won 2 |
| » Starters: Billy Pierce vs Mike Garcia | Second | 6 out |
| Monday, September 23 |
| » Lost to Athletics (57-90), 6-5 | Municipal Stadium (5-5) | 88-60 | |
| » Starters: Bob Keegan vs Alex Kellner | Second | 6½ out |
| Tuesday, September 24 |
| » Defeated Athletics (57-91), 7-6 | Municipal Stadium (6-5) | 89-60 | |
| » Starters: Bill Fischer vs George Brunet | Second | 6 out |
| Wednesday, September 25 |
| » Lost to Tigers (76-74), 5-0 | Comiskey Park I (44-29) | 89-61 | |
| » Starters: Billy Hoeft vs Jim Derrington | Second | 6½ out |
| Thursday, September 26 |
| » Lost to Tigers (77-74), 3-2 | Comiskey Park I (44-30) | 89-62 | Lost 2 |
| » Starters: Paul Foytack vs Bill Fischer | Second | 7 out |
| Friday, September 27 |
| » Defeated Indians (74-77), 2-1 | Comiskey Park I (45-30) | 90-62 | |
| » Starters: Don Mossi vs Jack Harshman | Second | 7 out |
| Saturday, September 28 |
| » Lost to Indians (75-77), 4-1 | Comiskey Park I (45-31) | 90-63 | |
| » Starters: Hank Aguirre vs Billy Pierce | Second | 8 out |
| Sunday, September 29 |
| » Lost to Indians (76-77), 5-3 | Comiskey Park I (45-32) | 90-64 | Lost 2 |
| » Starters: Bud Daley vs Barry Latman | Second | 8 out |
| Wednesday, October 9 |
| Former White Sox Butch Henline dies in Sarasota, FL at the age of 63. |
| Saturday, October 26 |
| Future White Sox Harry Chappas is born in Mount Rainier, MD. |
| Wednesday, December 4 |
| Former White Sox Jack Ness dies in DeLand, FL at the age of 74. |
| Monday, December 9 |
| Future White Sox Steve Christmas is born in Orlando, FL. |
| Saturday, December 21 |
| Former White Sox Marty Berghammer dies in Pittsburgh, PA at the age of 70. |
Game information provided by Retrosheet (www.retrosheet.org) |
