| Wednesday, January 16 |
| Future Tiger Marty Castillo is born in Long Beach, CA. |
| Saturday, February 9 |
| Future Tiger Pat Underwood is born in Kokomo, IN. |
| Sunday, March 3 |
| Future Tiger Skeeter Barnes is born in Cincinnati, OH. |
| Tuesday, March 5 |
| Future Tiger Jerry Ujdur is born in Duluth, MN. |
| Friday, March 8 |
| Future Tiger Bob Stoddard is born in San Jose, CA. |
| Monday, April 15 |
| » Major-league debuts: Neil Chrisley (Senators) |
| Former Tiger Jack Coombs dies in Palestine, TX at the age of 75. |
| Tuesday, April 16 |
| » Lost to Athletics (1-0), 2-1 | Municipal Stadium (0-1) | 0-1 | |
| » Starters: Frank Lary vs Tom Morgan | Third | 1 out |
| » Major-league debuts: Milt Graff (Athletics) |
| Wednesday, April 17 |
| » Lost to Athletics (2-0), 5-4 | Municipal Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Jim Bunning vs Ned Garver | Fifth | 2 out |
| Thursday, April 18 |
| » Lost to Indians (1-1), 8-3 | Tiger Stadium (0-1) | 0-3 | Lost 3 |
| » Starters: Bob Lemon vs Billy Hoeft | Fifth | 2½ out |
| Former Tiger Bill Sweeney dies in San Diego, CA at the age of 53. |
| Saturday, April 20 |
| » Defeated Indians (1-2), 7-0 | Tiger Stadium (1-1) | 1-3 | |
| » Starters: Early Wynn vs Frank Lary | Fourth | 2½ out |
| » Major-league debuts: Russ Nixon (Indians) |
| Sunday, April 21 |
| » Defeated Indians (1-3), 3-2 | Tiger Stadium (2-1) | 2-3 | Won 2 |
| » Starters: Mike Garcia vs Steve Gromek | Fifth | 2½ out |
| Monday, April 22 |
| » Lost to Athletics (3-3), 11-7 | Tiger Stadium (2-2) | 2-4 | |
| » Starters: Mickey McDermott vs Paul Foytack | Sixth | 3 out |
| Tuesday, April 23 |
| » Lost to Athletics (4-3), 5-4 | Tiger Stadium (2-3) | 2-5 | Lost 2 |
| » Starters: Rip Coleman vs Don Lee | Eighth | 3 out |
| » Major-league debuts: Don Lee (Tigers) |
| Thursday, April 25 |
| » Lost to White Sox (5-1), 9-4 | Comiskey Park I (0-1) | 2-6 | Lost 3 |
| » Starters: Billy Hoeft vs Jack Harshman | Eighth | 4 out |
| Friday, April 26 |
| » Defeated Indians (3-5), 5-0 | Cleveland Stadium (1-0) | 3-6 | |
| » Starters: Frank Lary vs Bob Lemon | Eighth | 4 out |
| Saturday, April 27 |
| » Lost to Indians (4-5), 2-1 | Cleveland Stadium (1-1) | 3-7 | |
| » Starters: Paul Foytack vs Herb Score | Eighth | 4 out |
| Sunday, April 28 |
| » Defeated Indians (4-6), 2-0 | Cleveland Stadium (2-1) | 4-7 | |
| » Starters: Don Lee vs Early Wynn | Eighth | 4½ out |
| » Lost to Indians (5-6), 3-2 | Cleveland Stadium (2-2) | 4-8 | |
| » Starters: Billy Hoeft vs Mike Garcia | Eighth | 4½ out |
| Tuesday, April 30 |
| » Defeated Yankees (6-5), 2-1 | Tiger Stadium (3-3) | 5-8 | |
| » Starters: Johnny Kucks vs Duke Maas | Seventh | 4½ out |
| Wednesday, May 1 |
| » Lost to Yankees (7-5), 7-4 | Tiger Stadium (3-4) | 5-9 | |
| » Starters: Art Ditmar vs Frank Lary | Seventh | 5½ out |
| Thursday, May 2 |
| » Defeated Red Sox (8-6), 7-5 | Tiger Stadium (4-4) | 6-9 | |
| » Starters: Tom Brewer vs Don Lee | Sixth | 5½ out |
| Friday, May 3 |
| » Defeated Red Sox (8-7), 6-0 | Tiger Stadium (5-4) | 7-9 | Won 2 |
| » Starters: Frank Sullivan vs Paul Foytack | Fifth | 5½ out |
| Saturday, May 4 |
| » Defeated Orioles (6-10), 3-0 | Tiger Stadium (6-4) | 8-9 | Won 3 |
| » Starters: Mike Fornieles vs Duke Maas | Fifth | 4½ out |
| Future Tiger Rick Leach is born in Ann Arbor, MI. |
| Sunday, May 5 |
| » Defeated Orioles (6-11), 3-1 | Tiger Stadium (7-4) | 9-9 | Won 4 |
| » Starters: Connie Johnson vs Frank Lary | Fifth | 3½ out |
| Monday, May 6 |
| » Lost to Orioles (7-11), 8-6 | Tiger Stadium (7-5) | 9-10 | |
| » Starters: Ray Moore vs Don Lee | Sixth | 4 out |
| Tuesday, May 7 |
| » Defeated Senators (5-17), 5-3 | Tiger Stadium (8-5) | 10-10 | |
| » Starters: Ted Abernathy vs Paul Foytack | Sixth | 3 out |
| Wednesday, May 8 |
| » Defeated Senators (5-18), 11-3 | Tiger Stadium (9-5) | 11-10 | Won 2 |
| » Starters: Russ Kemmerer vs Duke Maas | Fifth | 2 out |
| Thursday, May 9 |
| » Lost to Senators (6-18), 8-5 | Tiger Stadium (9-6) | 11-11 | |
| » Starters: Camilo Pascual vs Frank Lary | Fifth | 2½ out |
| Friday, May 10 |
| » Lost to White Sox (13-7), 6-4 | Tiger Stadium (9-7) | 11-12 | Lost 2 |
| » Starters: Billy Pierce vs Don Lee | Sixth | 3½ out |
| Sunday, May 12 |
| » Lost to White Sox (14-7), 5-4 | Tiger Stadium (9-8) | 11-13 | Lost 3 |
| » Starters: Jack Harshman vs Paul Foytack | Sixth | 4½ out |
| Future Tiger Lou Whitaker is born in Brooklyn, NY. |
| Tuesday, May 14 |
| » Defeated Red Sox (13-12), 2-0 | Fenway Park (1-0) | 12-13 | |
| » Starters: Duke Maas vs Frank Sullivan | Fifth | 4 out |
| Wednesday, May 15 |
| » Lost to Red Sox (14-12), 11-8 | Fenway Park (1-1) | 12-14 | |
| » Starters: Frank Lary vs Dean Stone | Fifth | 5 out |
| Thursday, May 16 |
| » Defeated Red Sox (14-13), 2-1 | Fenway Park (2-1) | 13-14 | |
| » Starters: Jim Bunning vs Bob Porterfield | Fifth | 5 out |
| Friday, May 17 |
| » Defeated Yankees (16-9), 4-1 | Yankee Stadium (1-0) | 14-14 | Won 2 |
| » Starters: Billy Hoeft vs Johnny Kucks | Fourth | 5 out |
| Saturday, May 18 |
| » Defeated Yankees (16-10), 2-1 | Yankee Stadium (2-0) | 15-14 | Won 3 |
| » Starters: Paul Foytack vs Don Larsen | Fourth | 4½ out |
| Sunday, May 19 |
| » Defeated Senators (8-24), 6-1 | Griffith Stadium (1-0) | 16-14 | Won 4 |
| » Starters: Duke Maas vs Chuck Stobbs | Third | 4½ out |
| Monday, May 20 |
| » Lost to Senators (9-24), 2-1 | Griffith Stadium (1-1) | 16-15 | |
| » Starters: Frank Lary vs Pedro Ramos | Third | 5 out |
| Tuesday, May 21 |
| » Defeated Orioles (11-18), 2-1 | Memorial Stadium (1-0) | 17-15 | |
| » Starters: Jim Bunning vs Ray Moore | Fourth | 5 out |
| Wednesday, May 22 |
| » Lost to Orioles (12-18), 4-3 | Memorial Stadium (1-1) | 17-16 | |
| » Starters: Billy Hoeft vs Art Ceccarelli | Fourth | 6 out |
| Saturday, May 25 |
| » Lost to Athletics (15-19), 5-3 | Municipal Stadium (0-3) | 17-17 | Lost 2 |
| » Starters: Paul Foytack vs Tom Morgan | Third | 6½ out |
| Sunday, May 26 |
| » Lost to Athletics (16-19), 3-1 | Municipal Stadium (0-4) | 17-18 | Lost 3 |
| » Starters: Duke Maas vs Ned Garver | Fourth | 7 out |
| Monday, May 27 |
| » Defeated Indians (20-14), 11-5 | Tiger Stadium (10-8) | 18-18 | |
| » Starters: Mike Garcia vs Frank Lary | Fifth | 6 out |
| Tuesday, May 28 |
| » Lost to Indians (21-14), 4-3 | Tiger Stadium (10-9) | 18-19 | |
| » Starters: Don Mossi vs Billy Hoeft | Fifth | 7 out |
| Future Tiger Kirk Gibson is born in Pontiac, MI. |
| Wednesday, May 29 |
| » Defeated Athletics (17-21), 4-3 | Tiger Stadium (11-9) | 19-19 | |
| » Starters: Ryne Duren vs Jim Bunning | Third | 6 out |
| Thursday, May 30 |
| » Defeated Athletics (17-22), 6-5 | Tiger Stadium (12-9) | 20-19 | Won 2 |
| » Starters: Tom Morgan vs Duke Maas | Fourth | 6 out |
| » Defeated Athletics (17-23), 3-2 | Tiger Stadium (13-9) | 21-19 | Won 3 |
| » Starters: Arnie Portocarrero vs Paul Foytack | Fourth | 6 out |
| Friday, May 31 |
| » Lost to White Sox (26-11), 6-0 | Comiskey Park I (0-2) | 21-20 | |
| » Starters: Frank Lary vs Bob Keegan | Fourth | 7 out |
| Saturday, June 1 |
| » Lost to White Sox (27-11), 12-4 | Comiskey Park I (0-3) | 21-21 | Lost 2 |
| » Starters: Billy Hoeft vs Jim Wilson | Fourth | 8 out |
| Sunday, June 2 |
| » Defeated White Sox (27-12), 3-1 | Comiskey Park I (1-3) | 22-21 | |
| » Starters: Jim Bunning vs Bill Fischer | Fifth | 8 out |
| » Lost to White Sox (28-12), 4-1 | Comiskey Park I (1-4) | 22-22 | |
| » Starters: Paul Foytack vs Jack Harshman | Fifth | 8 out |
| Tuesday, June 4 |
| » Lost to Senators (16-31), 4-3 | Tiger Stadium (13-10) | 22-23 | Lost 2 |
| » Starters: Tex Clevenger vs Duke Maas | Fifth | 9 out |
| Wednesday, June 5 |
| » Defeated Senators (16-32), 3-2 | Tiger Stadium (14-10) | 23-23 | |
| » Starters: Russ Kemmerer vs Frank Lary | Fourth | 9 out |
| Thursday, June 6 |
| » Defeated Senators (16-33), 7-6 | Tiger Stadium (15-10) | 24-23 | Won 2 |
| » Starters: Pedro Ramos vs Billy Hoeft | Fourth | 9 out |
| Friday, June 7 |
| » Defeated Yankees (27-19), 6-3 | Tiger Stadium (16-10) | 25-23 | Won 3 |
| » Starters: Don Larsen vs Jim Bunning | Third | 8 out |
| Saturday, June 8 |
| » Defeated Yankees (27-20), 7-4 | Tiger Stadium (17-10) | 26-23 | Won 4 |
| » Starters: Ralph Terry vs Paul Foytack | Third | 8 out |
| Sunday, June 9 |
| » Lost to Yankees (28-20), 5-4 | Tiger Stadium (17-11) | 26-24 | |
| » Starters: Tom Sturdivant vs Duke Maas | Fourth | 7½ out |
| Monday, June 10 |
| » Defeated Yankees (28-21), 9-4 | Tiger Stadium (18-11) | 27-24 | |
| » Starters: Bob Turley vs Frank Lary | Third | 7 out |
| Tuesday, June 11 |
| » Lost to Orioles (23-27), 4-1 | Tiger Stadium (18-12) | 27-25 | |
| » Starters: Connie Johnson vs Billy Hoeft | Fourth | 7 out |
| Wednesday, June 12 |
| » Defeated Orioles (23-28), 4-2 | Tiger Stadium (19-12) | 28-25 | |
| » Starters: Art Ceccarelli vs Jim Bunning | Fourth | 7 out |
| Thursday, June 13 |
| » Defeated Orioles (23-29), 2-1 | Tiger Stadium (20-12) | 29-25 | Won 2 |
| » Starters: Ray Moore vs Paul Foytack | Third | 6 out |
| » Major-league debuts: John Tsitouris (Tigers) |
| Friday, June 14 |
| » Defeated Red Sox (27-28), 5-4 | Tiger Stadium (21-12) | 30-25 | Won 3 |
| » Starters: Frank Sullivan vs Duke Maas | Third | 6 out |
| Saturday, June 15 |
| » Defeated Red Sox (27-29), 3-1 | Tiger Stadium (22-12) | 31-25 | Won 4 |
| » Starters: Willard Nixon vs Frank Lary | Third | 5 out |
| Sunday, June 16 |
| » Defeated Red Sox (27-30), 2-1 | Tiger Stadium (23-12) | 32-25 | Won 5 |
| » Starters: Mike Fornieles vs Jim Bunning | Third | 5½ out |
| Tuesday, June 18 |
| » Lost to Yankees (34-22), 2-1 | Yankee Stadium (2-1) | 32-26 | |
| » Starters: Billy Hoeft vs Bobby Shantz | Fourth | 5½ out |
| Wednesday, June 19 |
| » Lost to Yankees (35-22), 10-2 | Yankee Stadium (2-2) | 32-27 | Lost 2 |
| » Starters: Duke Maas vs Tom Sturdivant | Fourth | 6½ out |
| » Major-league debuts: Steve Boros (Tigers) |
| Thursday, June 20 |
| » Lost to Yankees (36-22), 3-1 | Yankee Stadium (2-3) | 32-28 | Lost 3 |
| » Starters: Frank Lary vs Bob Turley | Fourth | 6½ out |
| Friday, June 21 |
| » Lost to Orioles (27-33), 6-5 | Memorial Stadium (1-2) | 32-29 | Lost 4 |
| » Starters: Jim Bunning vs Connie Johnson | Third | 6½ out |
| Saturday, June 22 |
| » Defeated Orioles (27-34), 2-1 | Memorial Stadium (2-2) | 33-29 | |
| » Starters: Paul Foytack vs Billy O'Dell | Fourth | 6 out |
| Sunday, June 23 |
| » Lost to Orioles (28-34), 5-4 | Memorial Stadium (2-3) | 33-30 | |
| » Starters: Billy Hoeft vs Ray Moore | Fourth | 6½ out |
| Monday, June 24 |
| » Lost to Orioles (29-34), 6-0 | Memorial Stadium (2-4) | 33-31 | Lost 2 |
| » Starters: Duke Maas vs Hal Brown | Fourth | 7 out |
| Former Tiger Jack Burns dies in Waterford, CT at the age of 78. |
| Tuesday, June 25 |
| » Defeated Senators (22-46), 7-4 | Griffith Stadium (2-1) | 34-31 | |
| » Starters: Frank Lary vs Pedro Ramos | Fourth | 6½ out |
| Wednesday, June 26 |
| » Defeated Senators (22-47), 4-1 | Griffith Stadium (3-1) | 35-31 | Won 2 |
| » Starters: Jim Bunning vs Chuck Stobbs | Fourth | 6½ out |
| Thursday, June 27 |
| » Lost to Senators (23-47), 7-2 | Griffith Stadium (3-2) | 35-32 | |
| » Starters: Paul Foytack vs Camilo Pascual | Third | 6 out |
| » Major-league debuts: Bobo Osborne (Tigers) |
| Friday, June 28 |
| » Lost to Red Sox (36-33), 9-2 | Fenway Park (2-2) | 35-33 | Lost 2 |
| » Starters: Duke Maas vs Tom Brewer | Fourth | 7 out |
| Saturday, June 29 |
| » Lost to Red Sox (37-33), 12-4 | Fenway Park (2-3) | 35-34 | Lost 3 |
| » Starters: Frank Lary vs Dave Sisler | Fourth | 8 out |
| Future Tiger Eddie Miller is born in San Pablo, CA. |
| Sunday, June 30 |
| » Lost to Red Sox (38-33), 10-3 | Fenway Park (2-4) | 35-35 | Lost 4 |
| » Starters: Paul Foytack vs Willard Nixon | Fifth | 9½ out |
| Monday, July 1 |
| » Defeated White Sox (43-27), 5-2 | Tiger Stadium (24-12) | 36-35 | |
| » Starters: Jim Wilson vs Jim Bunning | Fifth | 9½ out |
| Tuesday, July 2 |
| » Lost to White Sox (44-27), 4-2 | Tiger Stadium (24-13) | 36-36 | |
| » Starters: Billy Pierce vs Frank Lary | Fifth | 10½ out |
| Wednesday, July 3 |
| » Lost to Indians (38-33), 6-0 | Cleveland Stadium (2-3) | 36-37 | Lost 2 |
| » Starters: Duke Maas vs Don Mossi | Fifth | 11½ out |
| Thursday, July 4 |
| » Lost to Indians (39-33), 3-1 | Cleveland Stadium (2-4) | 36-38 | Lost 3 |
| » Starters: Paul Foytack vs Early Wynn | Sixth | 11½ out |
| » Defeated Indians (39-34), 4-3 | Cleveland Stadium (3-4) | 37-38 | |
| » Starters: Billy Hoeft vs Ray Narleski | Sixth | 11½ out |
| Friday, July 5 |
| » Defeated Athletics (28-46), 8-4 | Tiger Stadium (25-13) | 38-38 | Won 2 |
| » Starters: Tom Gorman vs Jim Bunning | Fifth | 11½ out |
| Saturday, July 6 |
| » Lost to Athletics (29-46), 3-1 | Tiger Stadium (25-14) | 38-39 | |
| » Starters: Ralph Terry vs Frank Lary | Fifth | 12½ out |
| Sunday, July 7 |
| » Defeated Athletics (29-47), 5-2 | Tiger Stadium (26-14) | 39-39 | |
| » Starters: Arnie Portocarrero vs Paul Foytack | Fifth | 12½ out |
| Future Tiger Dan Gladden is born in San Jose, CA. |
| Thursday, July 11 |
| » Lost to Red Sox (43-37), 9-7 | Tiger Stadium (26-15) | 39-40 | |
| » Starters: Mike Fornieles vs Frank Lary | Fifth | 13½ out |
| Friday, July 12 |
| » Defeated Red Sox (43-38), 5-3 | Tiger Stadium (27-15) | 40-40 | |
| » Starters: Frank Sullivan vs Jim Bunning | Fourth | 13½ out |
| Saturday, July 13 |
| » Lost to Red Sox (44-38), 6-2 | Tiger Stadium (27-16) | 40-41 | |
| » Starters: Tom Brewer vs Paul Foytack | Fifth | 13½ out |
| Sunday, July 14 |
| » Defeated Orioles (39-42), 10-2 | Tiger Stadium (28-16) | 41-41 | |
| » Starters: Hal Brown vs Billy Hoeft | Fifth | 12½ out |
| » Defeated Orioles (39-43), 7-6 | Tiger Stadium (29-16) | 42-41 | Won 2 |
| » Starters: Billy Loes vs Don Lee | Fifth | 12½ out |
| Tuesday, July 16 |
| » Lost to Yankees (55-28), 10-4 | Tiger Stadium (29-17) | 42-42 | |
| » Starters: Johnny Kucks vs Frank Lary | Fifth | 13½ out |
| Wednesday, July 17 |
| » Lost to Yankees (56-28), 5-1 | Tiger Stadium (29-18) | 42-43 | Lost 2 |
| » Starters: Bob Turley vs Jim Bunning | Fifth | 14½ out |
| Thursday, July 18 |
| » Lost to Yankees (57-28), 3-2 | Tiger Stadium (29-19) | 42-44 | Lost 3 |
| » Starters: Don Larsen vs Billy Hoeft | Fifth | 15½ out |
| Friday, July 19 |
| » Defeated Senators (30-60), 4-1 | Tiger Stadium (30-19) | 43-44 | |
| » Starters: Pedro Ramos vs Paul Foytack | Fifth | 15½ out |
| Saturday, July 20 |
| » Lost to Senators (31-60), 4-3 | Tiger Stadium (30-20) | 43-45 | |
| » Starters: Russ Kemmerer vs Frank Lary | Fifth | 15½ out |
| Sunday, July 21 |
| » Defeated Senators (31-61), 6-5 | Tiger Stadium (31-20) | 44-45 | |
| » Starters: Tex Clevenger vs Jim Bunning | Fifth | 15 out |
| Tuesday, July 23 |
| » Defeated Orioles (43-47), 5-2 | Memorial Stadium (3-4) | 45-45 | Won 2 |
| » Starters: Billy Hoeft vs Billy O'Dell | Fifth | 15 out |
| Wednesday, July 24 |
| » Defeated Orioles (43-48), 5-1 | Memorial Stadium (4-4) | 46-45 | Won 3 |
| » Starters: Paul Foytack vs Billy Loes | Fifth | 14 out |
| Thursday, July 25 |
| » Lost to Orioles (44-48), 3-0 | Memorial Stadium (4-5) | 46-46 | |
| » Starters: Frank Lary vs Connie Johnson | Fifth | 14 out |
| Friday, July 26 |
| » Defeated Yankees (60-33), 3-2 | Yankee Stadium (3-3) | 47-46 | |
| » Starters: Jim Bunning vs Bob Turley | Fourth | 13 out |
| Saturday, July 27 |
| » Lost to Yankees (61-33), 4-3 | Yankee Stadium (3-4) | 47-47 | |
| » Starters: Duke Maas vs Tom Sturdivant | Fifth | 14 out |
| Sunday, July 28 |
| » Defeated Yankees (61-34), 6-5 | Yankee Stadium (4-4) | 48-47 | |
| » Starters: Paul Foytack vs Don Larsen | Fourth | 14 out |
| » Lost to Yankees (62-34), 4-3 | Yankee Stadium (4-5) | 48-48 | |
| » Starters: Billy Hoeft vs Johnny Kucks | Fourth | 14 out |
| Tuesday, July 30 |
| » Lost to Red Sox (54-44), 4-0 | Fenway Park (2-5) | 48-49 | Lost 2 |
| » Starters: Frank Lary vs Bob Porterfield | Fifth | 15 out |
| Wednesday, July 31 |
| » Defeated Red Sox (54-45), 5-3 | Fenway Park (3-5) | 49-49 | |
| » Starters: Jim Bunning vs Willard Nixon | Fifth | 15½ out |
| Future Tiger Howard Bailey is born in Grand Haven, MI. |
| Thursday, August 1 |
| » Defeated Red Sox (54-46), 7-5 | Fenway Park (4-5) | 50-49 | Won 2 |
| » Starters: Duke Maas vs Mike Fornieles | Fourth | 15 out |
| Friday, August 2 |
| » Lost to Senators (37-66), 2-1 | Griffith Stadium (3-3) | 50-50 | |
| » Starters: Paul Foytack vs Camilo Pascual | Fourth | 16 out |
| Saturday, August 3 |
| » Lost to Senators (38-66), 4-3 | Griffith Stadium (3-4) | 50-51 | Lost 2 |
| » Starters: Billy Hoeft vs Russ Kemmerer | Fourth | 17 out |
| Sunday, August 4 |
| » Lost to Senators (39-66), 8-4 | Griffith Stadium (3-5) | 50-52 | Lost 3 |
| » Starters: Frank Lary vs Pedro Ramos | Fourth | 18½ out |
| Tuesday, August 6 |
| » Lost to Indians (52-53), 5-1 | Tiger Stadium (31-21) | 50-53 | Lost 4 |
| » Starters: Don Mossi vs Jim Bunning | Sixth | 19 out |
| Wednesday, August 7 |
| » Defeated Indians (52-54), 4-1 | Tiger Stadium (32-21) | 51-53 | |
| » Starters: Johnny Gray vs Billy Hoeft | Fifth | 18 out |
| Thursday, August 8 |
| » Lost to Indians (53-54), 3-1 | Tiger Stadium (32-22) | 51-54 | |
| » Starters: Ray Narleski vs Duke Maas | Sixth | 18 out |
| Friday, August 9 |
| » Lost to White Sox (65-41), 5-4 | Comiskey Park I (1-5) | 51-55 | Lost 2 |
| » Starters: Paul Foytack vs Dick Donovan | Sixth | 18 out |
| Future Tiger John Moses is born in Los Angeles, CA. |
| Saturday, August 10 |
| » Defeated White Sox (65-42), 6-4 | Comiskey Park I (2-5) | 52-55 | |
| » Starters: Frank Lary vs Jim Derrington | Fifth | 18 out |
| Sunday, August 11 |
| » Defeated White Sox (65-43), 8-5 | Comiskey Park I (3-5) | 53-55 | Won 2 |
| » Starters: Jim Bunning vs Bob Keegan | Fourth | 18½ out |
| » Lost to White Sox (66-43), 11-2 | Comiskey Park I (3-6) | 53-56 | |
| » Starters: Billy Hoeft vs Jim Wilson | Fourth | 18½ out |
| » Major-league debuts: Bob Shaw (Tigers) |
| Tuesday, August 13 |
| » Defeated Athletics (41-70), 3-1 | Municipal Stadium (1-4) | 54-56 | |
| » Starters: Paul Foytack vs Arnie Portocarrero | Fifth | 19 out |
| » Lost to Athletics (42-70), 3-2 | Municipal Stadium (1-5) | 54-57 | |
| » Starters: Duke Maas vs Tom Gorman | Fifth | 19 out |
| Wednesday, August 14 |
| » Defeated Athletics (42-71), 7-4 | Municipal Stadium (2-5) | 55-57 | |
| » Starters: Frank Lary vs Ralph Terry | Fifth | 18 out |
| Thursday, August 15 |
| » Lost to Athletics (43-71), 7-2 | Municipal Stadium (2-6) | 55-58 | |
| » Starters: Jim Bunning vs Jack Urban | Fifth | 19 out |
| Friday, August 16 |
| » Defeated White Sox (68-45), 6-2 | Tiger Stadium (33-22) | 56-58 | |
| » Starters: Jim Wilson vs Billy Hoeft | Fifth | 18 out |
| Saturday, August 17 |
| » Defeated White Sox (68-46), 9-8 | Tiger Stadium (34-22) | 57-58 | Won 2 |
| » Starters: Jim Derrington vs Harry Byrd | Fifth | 18 out |
| Sunday, August 18 |
| » Defeated White Sox (68-47), 5-1 | Tiger Stadium (35-22) | 58-58 | Won 3 |
| » Starters: Billy Pierce vs Frank Lary | Fourth | 19 out |
| » Lost to White Sox (69-47), 4-1 | Tiger Stadium (35-23) | 58-59 | |
| » Starters: Dick Donovan vs Duke Maas | Fourth | 19 out |
| Tuesday, August 20 |
| » Defeated Orioles (56-60), 5-1 | Tiger Stadium (36-23) | 59-59 | |
| » Starters: Hal Brown vs Jim Bunning | Fourth | 18 out |
| Wednesday, August 21 |
| » Lost to Orioles (57-60), 9-3 | Tiger Stadium (36-24) | 59-60 | |
| » Starters: Ray Moore vs Billy Hoeft | Fourth | 18 out |
| Thursday, August 22 |
| » Defeated Orioles (57-61), 4-0 | Tiger Stadium (37-24) | 60-60 | |
| » Starters: Billy O'Dell vs Frank Lary | Fourth | 18 out |
| Friday, August 23 |
| » Defeated Senators (46-75), 13-4 | Tiger Stadium (38-24) | 61-60 | Won 2 |
| » Starters: Pedro Ramos vs Duke Maas | Fourth | 17 out |
| Saturday, August 24 |
| » Lost to Senators (47-75), 6-3 | Tiger Stadium (38-25) | 61-61 | |
| » Starters: Tex Clevenger vs Jim Bunning | Fourth | 18 out |
| Sunday, August 25 |
| » Defeated Yankees (79-44), 7-2 | Tiger Stadium (39-25) | 62-61 | |
| » Starters: Bob Turley vs Billy Hoeft | Fourth | 17 out |
| Monday, August 26 |
| » Defeated Yankees (79-45), 5-2 | Tiger Stadium (40-25) | 63-61 | Won 2 |
| » Starters: Tommy Byrne vs Frank Lary | Fourth | 16 out |
| Tuesday, August 27 |
| » Lost to Red Sox (65-59), 7-5 | Tiger Stadium (40-26) | 63-62 | |
| » Starters: Mike Fornieles vs Paul Foytack | Fourth | 17 out |
| Wednesday, August 28 |
| » Lost to Red Sox (66-59), 1-0 | Tiger Stadium (40-27) | 63-63 | Lost 2 |
| » Starters: Frank Sullivan vs Jim Bunning | Fourth | 18 out |
| Thursday, August 29 |
| » Lost to Red Sox (67-59), 6-1 | Tiger Stadium (40-28) | 63-64 | Lost 3 |
| » Starters: Tom Brewer vs Duke Maas | Fourth | 19 out |
| Friday, August 30 |
| » Lost to Indians (63-66), 6-5 | Cleveland Stadium (3-5) | 63-65 | Lost 4 |
| » Starters: Billy Hoeft vs Cal McLish | Fourth | 19 out |
| Saturday, August 31 |
| » Defeated Indians (63-67), 8-7 | Cleveland Stadium (4-5) | 64-65 | |
| » Starters: Frank Lary vs Early Wynn | Fourth | 18 out |
| Sunday, September 1 |
| » Defeated Indians (63-68), 6-1 | Cleveland Stadium (5-5) | 65-65 | Won 2 |
| » Starters: Jim Bunning vs Ray Narleski | Fourth | 18 out |
| Future Tiger Dave Rucker is born in San Bernardino, CA. |
| Monday, September 2 |
| » Lost to White Sox (78-52), 8-2 | Tiger Stadium (40-29) | 65-66 | |
| » Starters: Billy Pierce vs Duke Maas | Fourth | 17 out |
| » Defeated White Sox (78-53), 5-4 | Tiger Stadium (41-29) | 66-66 | |
| » Starters: Dick Donovan vs Frank Lary | Fourth | 17 out |
| Tuesday, September 3 |
| » Defeated White Sox (78-54), 3-2 | Tiger Stadium (42-29) | 67-66 | Won 2 |
| » Starters: Bob Keegan vs Billy Hoeft | Fourth | 17 out |
| Friday, September 6 |
| » Defeated Indians (65-69), 5-2 | Tiger Stadium (43-29) | 68-66 | Won 3 |
| » Starters: Early Wynn vs Jim Bunning | Fourth | 16 out |
| Saturday, September 7 |
| » Lost to Indians (66-69), 5-4 | Tiger Stadium (43-30) | 68-67 | |
| » Starters: Mike Garcia vs Frank Lary | Fourth | 17 out |
| Sunday, September 8 |
| » Defeated Indians (66-70), 3-1 | Tiger Stadium (44-30) | 69-67 | |
| » Starters: Cal McLish vs Billy Hoeft | Fourth | 17 out |
| Tuesday, September 10 |
| » Major-league debuts: Barry Latman (White Sox) |
| Wednesday, September 11 |
| » Defeated Senators (52-85), 3-0 | Griffith Stadium (4-5) | 70-67 | Won 2 |
| » Starters: Jim Bunning vs Camilo Pascual | Fourth | 16 out |
| » Defeated Senators (52-86), 12-2 | Griffith Stadium (5-5) | 71-67 | Won 3 |
| » Starters: Frank Lary vs Pedro Ramos | Fourth | 16 out |
| » Major-league debuts: George Thomas (Tigers) |
| Thursday, September 12 |
| » Defeated Senators (52-87), 8-5 | Griffith Stadium (6-5) | 72-67 | Won 4 |
| » Starters: Duke Maas vs Chuck Stobbs | Fourth | 15½ out |
| Saturday, September 14 |
| » Lost to Orioles (67-72), 3-1 | Memorial Stadium (4-6) | 72-68 | |
| » Starters: Billy Hoeft vs Billy O'Dell | Fourth | 15½ out |
| » Defeated Orioles (67-73), 4-3 | Memorial Stadium (5-6) | 73-68 | |
| » Starters: Paul Foytack vs Connie Johnson | Fourth | 15½ out |
| Future Tiger Jerry Don Gleaton is born in Brownwood, TX. |
| Sunday, September 15 |
| » Defeated Red Sox (76-66), 7-1 | Fenway Park (5-5) | 74-68 | Won 2 |
| » Starters: Jim Bunning vs Willard Nixon | Fourth | 15½ out |
| » Defeated Red Sox (76-67), 4-3 | Fenway Park (6-5) | 75-68 | Won 3 |
| » Starters: Frank Lary vs Tom Brewer | Fourth | 15½ out |
| Tuesday, September 17 |
| » Lost to Yankees (92-53), 7-1 | Yankee Stadium (4-6) | 75-69 | |
| » Starters: Billy Hoeft vs Bobby Shantz | Fourth | 16½ out |
| Wednesday, September 18 |
| » Lost to Yankees (93-53), 4-3 | Yankee Stadium (4-7) | 75-70 | Lost 2 |
| » Starters: Duke Maas vs Sal Maglie | Fourth | 17½ out |
| Saturday, September 21 |
| » Lost to Athletics (54-90), 6-3 | Municipal Stadium (2-7) | 75-71 | Lost 3 |
| » Starters: Jim Bunning vs Jack Urban | Fourth | 18 out |
| Sunday, September 22 |
| » Lost to Athletics (55-90), 4-3 | Municipal Stadium (2-8) | 75-72 | Lost 4 |
| » Starters: Paul Foytack vs Ralph Terry | Fourth | 19½ out |
| » Lost to Athletics (56-90), 2-1 | Municipal Stadium (2-9) | 75-73 | Lost 5 |
| » Starters: Duke Maas vs Ned Garver | Fourth | 19½ out |
| Monday, September 23 |
| » Lost to Indians (72-76), 5-4 | Cleveland Stadium (5-6) | 75-74 | Lost 6 |
| » Starters: Jim Bunning vs Cal McLish | Fourth | 20 out |
| Wednesday, September 25 |
| » Defeated White Sox (89-61), 5-0 | Comiskey Park I (4-6) | 76-74 | |
| » Starters: Billy Hoeft vs Jim Derrington | Fourth | 19½ out |
| Thursday, September 26 |
| » Defeated White Sox (89-62), 3-2 | Comiskey Park I (5-6) | 77-74 | Won 2 |
| » Starters: Paul Foytack vs Bill Fischer | Fourth | 19 out |
| Friday, September 27 |
| » Lost to Athletics (58-93), 9-7 | Tiger Stadium (44-31) | 77-75 | |
| » Starters: Jack Urban vs Jim Bunning | Fourth | 20 out |
| Saturday, September 28 |
| » Lost to Athletics (59-93), 5-3 | Tiger Stadium (44-32) | 77-76 | Lost 2 |
| » Starters: Arnie Portocarrero vs Frank Lary | Fourth | 21 out |
| Sunday, September 29 |
| » Defeated Athletics (59-94), 7-4 | Tiger Stadium (45-32) | 78-76 | |
