| Thursday, January 17 |
| Former Senator Carl Sawyer dies in Los Angeles, CA at the age of 67. |
| Monday, April 15 |
| » Lost to Orioles (1-0), 7-6 | Griffith Stadium (0-1) | 0-1 | |
| » Starters: Hal Brown vs Bob Chakales | Third | 1 out |
| » Major-league debuts: Neil Chrisley (Senators) |
| Tuesday, April 16 |
| » Lost to Yankees (1-0), 2-1 | Yankee Stadium (0-1) | 0-2 | Lost 2 |
| » Starters: Chuck Stobbs vs Whitey Ford | Fourth | 1½ out |
| Thursday, April 18 |
| » Defeated Orioles (1-2), 6-4 | Griffith Stadium (1-1) | 1-2 | |
| » Starters: Ray Moore vs Ted Abernathy | Fourth | 1½ out |
| Saturday, April 20 |
| » Defeated Orioles (1-3), 6-4 | Griffith Stadium (2-1) | 2-2 | Won 2 |
| » Starters: Connie Johnson vs Camilo Pascual | Second | 1½ out |
| Sunday, April 21 |
| » Lost to Orioles (2-3), 11-9 | Griffith Stadium (2-2) | 2-3 | |
| » Starters: Charlie Beamon vs Bob Chakales | Fourth | 2 out |
| » Defeated Orioles (2-4), 3-2 | Griffith Stadium (3-2) | 3-3 | |
| » Starters: Hal Brown vs Evelio Hernandez | Fourth | 2 out |
| Monday, April 22 |
| » Lost to Yankees (4-1), 15-6 | Griffith Stadium (3-3) | 3-4 | |
| » Starters: Whitey Ford vs Chuck Stobbs | Fourth | 2½ out |
| » Major-league debuts: Al Cicotte (Yankees) |
| Tuesday, April 23 |
| » Defeated Yankees (4-2), 3-1 | Griffith Stadium (4-3) | 4-4 | |
| » Starters: Johnny Kucks vs Ted Abernathy | Fifth | 1½ out |
| Wednesday, April 24 |
| » Lost to Red Sox (4-3), 4-3 | Griffith Stadium (4-4) | 4-5 | |
| » Starters: Russ Meyer vs Pedro Ramos | Fifth | 2 out |
| Thursday, April 25 |
| » Lost to Red Sox (5-3), 12-7 | Griffith Stadium (4-5) | 4-6 | Lost 2 |
| » Starters: Willard Nixon vs Evelio Hernandez | Sixth | 3 out |
| Friday, April 26 |
| » Lost to Orioles (4-6), 4-3 | Memorial Stadium (0-1) | 4-7 | Lost 3 |
| » Starters: Camilo Pascual vs Ray Moore | Seventh | 4 out |
| Saturday, April 27 |
| » Lost to Orioles (5-6), 4-0 | Memorial Stadium (0-2) | 4-8 | Lost 4 |
| » Starters: Chuck Stobbs vs Mike Fornieles | Seventh | 4 out |
| Sunday, April 28 |
| » Defeated Orioles (5-7), 7-6 | Memorial Stadium (1-2) | 5-8 | |
| » Starters: Garland Shifflett vs Don Ferrarese | Seventh | 4½ out |
| » Lost to Orioles (6-7), 3-2 | Memorial Stadium (1-3) | 5-9 | |
| » Starters: Ted Abernathy vs Hal Brown | Seventh | 4½ out |
| Tuesday, April 30 |
| » Lost to Indians (6-6), 5-1 | Cleveland Stadium (0-1) | 5-10 | Lost 2 |
| » Starters: Pedro Ramos vs Bob Lemon | Eighth | 5½ out |
| Wednesday, May 1 |
| » Lost to Indians (7-6), 7-6 | Cleveland Stadium (0-2) | 5-11 | Lost 3 |
| » Starters: Camilo Pascual vs Herb Score | Eighth | 6½ out |
| Thursday, May 2 |
| » Lost to White Sox (10-2), 6-1 | Comiskey Park I (0-1) | 5-12 | Lost 4 |
| » Starters: Chuck Stobbs vs Dick Donovan | Seventh | 7½ out |
| Friday, May 3 |
| » Lost to White Sox (11-2), 11-6 | Comiskey Park I (0-2) | 5-13 | Lost 5 |
| » Starters: Russ Kemmerer vs Bob Keegan | Seventh | 8½ out |
| Saturday, May 4 |
| » Lost to Athletics (8-9), 8-2 | Municipal Stadium (0-1) | 5-14 | Lost 6 |
| » Starters: Ted Abernathy vs Arnie Portocarrero | Seventh | 8½ out |
| Sunday, May 5 |
| » Lost to Athletics (9-9), 7-2 | Municipal Stadium (0-2) | 5-15 | Lost 7 |
| » Starters: Camilo Pascual vs Tom Morgan | Seventh | 8½ out |
| Monday, May 6 |
| » Lost to Athletics (10-9), 8-2 | Municipal Stadium (0-3) | 5-16 | Lost 8 |
| » Starters: Chuck Stobbs vs Ned Garver | Eighth | 9 out |
| Tuesday, May 7 |
| » Lost to Tigers (10-10), 5-3 | Tiger Stadium (0-1) | 5-17 | Lost 9 |
| » Manager: Cookie Lavagetto |
| » Starters: Ted Abernathy vs Paul Foytack | Eighth | 9 out |
| Wednesday, May 8 |
| » Lost to Tigers (11-10), 11-3 | Tiger Stadium (0-2) | 5-18 | Lost 10 |
| » Starters: Russ Kemmerer vs Duke Maas | Seventh | 9 out |
| Thursday, May 9 |
| » Defeated Tigers (11-11), 8-5 | Tiger Stadium (1-2) | 6-18 | |
| » Starters: Camilo Pascual vs Frank Lary | Seventh | 8½ out |
| Sunday, May 12 |
| » Lost to Red Sox (13-9), 10-0 | Fenway Park (0-1) | 6-19 | |
| » Starters: Chuck Stobbs vs Tom Brewer | Eighth | 9½ out |
| » Defeated Red Sox (13-10), 6-2 | Fenway Park (1-1) | 7-19 | |
| » Starters: Pedro Ramos vs Dave Sisler | Eighth | 9½ out |
| Monday, May 13 |
| » Defeated Red Sox (13-11), 5-3 | Fenway Park (2-1) | 8-19 | Won 2 |
| » Starters: Ted Abernathy vs Willard Nixon | Eighth | 9 out |
| Wednesday, May 15 |
| » Lost to White Sox (15-7), 5-0 | Griffith Stadium (4-6) | 8-20 | |
| » Starters: Jim Wilson vs Chuck Stobbs | Seventh | 10 out |
| Thursday, May 16 |
| » Lost to White Sox (16-7), 8-3 | Griffith Stadium (4-7) | 8-21 | Lost 2 |
| » Starters: Billy Pierce vs Pedro Ramos | Eighth | 11 out |
| Friday, May 17 |
| » Lost to Indians (16-9), 3-1 | Griffith Stadium (4-8) | 8-22 | Lost 3 |
| » Starters: Bud Daley vs Camilo Pascual | Seventh | 12 out |
| Saturday, May 18 |
| » Lost to Indians (17-9), 8-1 | Griffith Stadium (4-9) | 8-23 | Lost 4 |
| » Starters: Mike Garcia vs Ted Abernathy | Seventh | 12½ out |
| Sunday, May 19 |
| » Lost to Tigers (16-14), 6-1 | Griffith Stadium (4-10) | 8-24 | Lost 5 |
| » Starters: Duke Maas vs Chuck Stobbs | Seventh | 13½ out |
| Monday, May 20 |
| » Defeated Tigers (16-15), 2-1 | Griffith Stadium (5-10) | 9-24 | |
| » Starters: Frank Lary vs Pedro Ramos | Seventh | 13 out |
| Tuesday, May 21 |
| » Defeated Athletics (13-19), 3-0 | Griffith Stadium (6-10) | 10-24 | Won 2 |
| » Starters: Ryne Duren vs Camilo Pascual | Eighth | 13 out |
| Wednesday, May 22 |
| » Lost to Athletics (14-19), 8-6 | Griffith Stadium (6-11) | 10-25 | |
| » Starters: Alex Kellner vs Ted Abernathy | Eighth | 14 out |
| Friday, May 24 |
| » Lost to Yankees (18-12), 8-1 | Yankee Stadium (0-2) | 10-26 | Lost 2 |
| » Starters: Chuck Stobbs vs Tom Sturdivant | Seventh | 14 out |
| Saturday, May 25 |
| » Lost to Yankees (19-12), 8-1 | Yankee Stadium (0-3) | 10-27 | Lost 3 |
| » Starters: Pedro Ramos vs Bobby Shantz | Sixth | 15 out |
| Sunday, May 26 |
| » Defeated Yankees (19-13), 9-7 | Yankee Stadium (1-3) | 11-27 | |
| » Starters: Camilo Pascual vs Don Larsen | Seventh | 15 out |
| » Lost to Yankees (20-13), 7-6 | Yankee Stadium (1-4) | 11-28 | |
| » Starters: Ted Abernathy vs Bob Turley | Seventh | 15 out |
| Monday, May 27 |
| » Defeated Orioles (13-22), 10-6 | Griffith Stadium (7-11) | 12-28 | |
| » Starters: Connie Johnson vs Russ Kemmerer | Eighth | 14 out |
| Wednesday, May 29 |
| » Defeated Yankees (22-14), 6-2 | Griffith Stadium (8-11) | 13-28 | Won 2 |
| » Starters: Tom Sturdivant vs Pedro Ramos | Seventh | 13½ out |
| Thursday, May 30 |
| » Defeated Yankees (22-15), 5-1 | Griffith Stadium (9-11) | 14-28 | Won 3 |
| » Starters: Al Cicotte vs Camilo Pascual | Eighth | 14½ out |
| » Lost to Yankees (23-15), 9-0 | Griffith Stadium (9-12) | 14-29 | |
| » Starters: Bobby Shantz vs Ted Abernathy | Eighth | 14½ out |
| Friday, May 31 |
| » Defeated Red Sox (21-21), 3-2 | Griffith Stadium (10-12) | 15-29 | |
| » Starters: Tom Brewer vs Russ Kemmerer | Eighth | 14½ out |
| Saturday, June 1 |
| » Lost to Red Sox (22-21), 11-1 | Griffith Stadium (10-13) | 15-30 | |
| » Starters: Willard Nixon vs Chuck Stobbs | Seventh | 15½ out |
| Sunday, June 2 |
| » Lost to Red Sox (23-21), 5-3 | Griffith Stadium (10-14) | 15-31 | Lost 2 |
| » Starters: George Susce vs Pedro Ramos | Eighth | 16 out |
| Tuesday, June 4 |
| » Defeated Tigers (22-23), 4-3 | Tiger Stadium (2-2) | 16-31 | |
| » Starters: Tex Clevenger vs Duke Maas | Eighth | 16 out |
| Wednesday, June 5 |
| » Lost to Tigers (23-23), 3-2 | Tiger Stadium (2-3) | 16-32 | |
| » Starters: Russ Kemmerer vs Frank Lary | Seventh | 17 out |
| Thursday, June 6 |
| » Lost to Tigers (24-23), 7-6 | Tiger Stadium (2-4) | 16-33 | Lost 2 |
| » Starters: Pedro Ramos vs Billy Hoeft | Eighth | 18 out |
| Friday, June 7 |
| » Defeated Indians (23-22), 11-7 | Cleveland Stadium (1-2) | 17-33 | |
| » Starters: Chuck Stobbs vs Bud Daley | Eighth | 17 out |
| Saturday, June 8 |
| » Lost to Indians (24-22), 6-4 | Cleveland Stadium (1-3) | 17-34 | |
| » Starters: Camilo Pascual vs Don Mossi | Eighth | 18 out |
| Sunday, June 9 |
| » Lost to Indians (25-22), 7-2 | Cleveland Stadium (1-4) | 17-35 | Lost 2 |
| » Starters: Russ Kemmerer vs Early Wynn | Eighth | 17 out |
| » Defeated Indians (25-23), 7-6 | Cleveland Stadium (2-4) | 18-35 | |
| » Starters: Pedro Ramos vs Mike Garcia | Eighth | 17 out |
| Wednesday, June 12 |
| » Lost to Athletics (22-29), 5-3 | Municipal Stadium (0-4) | 18-36 | |
| » Starters: Camilo Pascual vs Arnie Portocarrero | Eighth | 17 out |
| » Defeated Athletics (22-30), 3-2 | Municipal Stadium (1-4) | 19-36 | |
| » Starters: Ted Abernathy vs Ned Garver | Eighth | 17 out |
| Thursday, June 13 |
| » Lost to Athletics (23-30), 6-2 | Municipal Stadium (1-5) | 19-37 | |
| » Starters: Pedro Ramos vs Jack Urban | Eighth | 17 out |
| Friday, June 14 |
| » Lost to White Sox (34-17), 10-4 | Comiskey Park I (0-3) | 19-38 | Lost 2 |
| » Starters: Chuck Stobbs vs Dick Donovan | Eighth | 18 out |
| Saturday, June 15 |
| » Defeated White Sox (34-18), 9-1 | Comiskey Park I (1-3) | 20-38 | |
| » Starters: Russ Kemmerer vs Bill Fischer | Eighth | 17 out |
| Sunday, June 16 |
| » Lost to White Sox (35-18), 4-2 | Comiskey Park I (1-4) | 20-39 | |
| » Starters: Pedro Ramos vs Jim Wilson | Eighth | 19 out |
| » Lost to White Sox (36-18), 8-6 | Comiskey Park I (1-5) | 20-40 | Lost 2 |
| » Starters: Tex Clevenger vs Jack Harshman | Eighth | 19 out |
| Tuesday, June 18 |
| » Lost to Athletics (24-33), 2-0 | Griffith Stadium (10-15) | 20-41 | Lost 3 |
| » Starters: Ralph Terry vs Ted Abernathy | Eighth | 19 out |
| » Major-league debuts: Bob Martyn (Athletics) |
| Wednesday, June 19 |
| » Lost to Athletics (25-33), 6-3 | Griffith Stadium (10-16) | 20-42 | Lost 4 |
| » Starters: Ned Garver vs Russ Kemmerer | Seventh | 20 out |
| Thursday, June 20 |
| » Defeated Athletics (25-34), 9-4 | Griffith Stadium (11-16) | 21-42 | |
| » Starters: Jack Urban vs Pedro Ramos | Eighth | 19 out |
| Former Senator Cy Warmoth dies in Mt.Carmel, IL at the age of 65. |
| Friday, June 21 |
| » Defeated Indians (31-28), 6-3 | Griffith Stadium (12-16) | 22-42 | Won 2 |
| » Starters: Don Mossi vs Chuck Stobbs | Eighth | 18 out |
| Saturday, June 22 |
| » Lost to Indians (32-28), 7-1 | Griffith Stadium (12-17) | 22-43 | |
| » Starters: Bob Lemon vs Camilo Pascual | Eighth | 18½ out |
| Sunday, June 23 |
| » Lost to Indians (33-28), 14-2 | Griffith Stadium (12-18) | 22-44 | Lost 2 |
| » Starters: Early Wynn vs Ted Abernathy | Eighth | 19½ out |
| » Lost to Indians (34-28), 7-5 | Griffith Stadium (12-19) | 22-45 | Lost 3 |
| » Starters: Mike Garcia vs Russ Kemmerer | Eighth | 19½ out |
| Tuesday, June 25 |
| » Lost to Tigers (34-31), 7-4 | Griffith Stadium (12-20) | 22-46 | Lost 4 |
| » Starters: Frank Lary vs Pedro Ramos | Eighth | 20 out |
| Wednesday, June 26 |
| » Lost to Tigers (35-31), 4-1 | Griffith Stadium (12-21) | 22-47 | Lost 5 |
| » Starters: Jim Bunning vs Chuck Stobbs | Eighth | 21 out |
| Thursday, June 27 |
| » Defeated Tigers (35-32), 7-2 | Griffith Stadium (13-21) | 23-47 | |
| » Starters: Paul Foytack vs Camilo Pascual | Seventh | 19½ out |
| » Major-league debuts: Bobo Osborne (Tigers) |
| Friday, June 28 |
| » Lost to White Sox (41-25), 4-3 | Griffith Stadium (13-22) | 23-48 | |
| » Starters: Dick Donovan vs Russ Kemmerer | Seventh | 20½ out |
| Saturday, June 29 |
| » Lost to White Sox (42-25), 7-1 | Griffith Stadium (13-23) | 23-49 | Lost 2 |
| » Starters: Jack Harshman vs Jim Heise | Seventh | 21½ out |
| Sunday, June 30 |
| » Lost to White Sox (43-25), 7-6 | Griffith Stadium (13-24) | 23-50 | Lost 3 |
| » Starters: Bob Keegan vs Chuck Stobbs | Eighth | 22½ out |
| » Defeated White Sox (43-26), 11-9 | Griffith Stadium (14-24) | 24-50 | |
| » Starters: Jim Derrington vs Pedro Ramos | Eighth | 22½ out |
| Monday, July 1 |
| » Defeated Red Sox (38-34), 5-4 | Fenway Park (3-1) | 25-50 | Won 2 |
| » Starters: Ted Abernathy vs Mike Fornieles | Eighth | 22½ out |
| Tuesday, July 2 |
| » Lost to Red Sox (39-34), 2-1 | Fenway Park (3-2) | 25-51 | |
| » Starters: Camilo Pascual vs Frank Sullivan | Eighth | 23½ out |
| Wednesday, July 3 |
| » Lost to Orioles (35-37), 8-3 | Memorial Stadium (1-4) | 25-52 | Lost 2 |
| » Starters: Jim Heise vs Ray Moore | Eighth | 24½ out |
| Thursday, July 4 |
| » Lost to Orioles (36-37), 3-2 | Memorial Stadium (1-5) | 25-53 | Lost 3 |
| » Starters: Chuck Stobbs vs Bill Wight | Eighth | 25 out |
| Friday, July 5 |
| » Lost to Yankees (49-26), 5-3 | Griffith Stadium (14-25) | 25-54 | Lost 4 |
| » Starters: Tom Sturdivant vs Pedro Ramos | Eighth | 26 out |
| Saturday, July 6 |
| » Lost to Yankees (50-26), 10-6 | Griffith Stadium (14-26) | 25-55 | Lost 5 |
| » Starters: Johnny Kucks vs Russ Kemmerer | Eighth | 27 out |
| Sunday, July 7 |
| » Lost to Yankees (51-26), 7-5 | Griffith Stadium (14-27) | 25-56 | Lost 6 |
| » Starters: Whitey Ford vs Camilo Pascual | Eighth | 28 out |
| Thursday, July 11 |
| » Defeated White Sox (49-30), 6-5 | Comiskey Park I (2-5) | 26-56 | |
| » Starters: Pedro Ramos vs Jim Wilson | Seventh | 28 out |
| Saturday, July 13 |
| » Lost to White Sox (50-30), 7-4 | Comiskey Park I (2-6) | 26-57 | |
| » Starters: Chuck Stobbs vs Jack Harshman | Eighth | 28½ out |
| Sunday, July 14 |
| » Defeated Athletics (30-50), 4-1 | Municipal Stadium (2-5) | 27-57 | |
| » Starters: Camilo Pascual vs Ned Garver | Eighth | 28½ out |
| » Lost to Athletics (31-50), 11-3 | Municipal Stadium (2-6) | 27-58 | |
| » Starters: Pedro Ramos vs Tom Gorman | Eighth | 28½ out |
| Monday, July 15 |
| » Defeated Athletics (31-51), 10-3 | Municipal Stadium (3-6) | 28-58 | |
| » Starters: Russ Kemmerer vs Wally Burnette | Eighth | 28 out |
| Tuesday, July 16 |
| » Lost to Indians (44-40), 9-3 | Cleveland Stadium (2-5) | 28-59 | |
| » Starters: Ted Abernathy vs Early Wynn | Eighth | 29 out |
| Wednesday, July 17 |
| » Defeated Indians (44-41), 11-6 | Cleveland Stadium (3-5) | 29-59 | |
| » Starters: Chuck Stobbs vs Don Mossi | Eighth | 29 out |
| Thursday, July 18 |
| » Defeated Indians (44-42), 4-0 | Cleveland Stadium (4-5) | 30-59 | Won 2 |
| » Starters: Camilo Pascual vs Stan Pitula | Eighth | 29 out |
| Friday, July 19 |
| » Lost to Tigers (43-44), 4-1 | Tiger Stadium (2-5) | 30-60 | |
| » Starters: Pedro Ramos vs Paul Foytack | Eighth | 30 out |
| Saturday, July 20 |
| » Defeated Tigers (43-45), 4-3 | Tiger Stadium (3-5) | 31-60 | |
| » Starters: Russ Kemmerer vs Frank Lary | Eighth | 29 out |
| Sunday, July 21 |
| » Lost to Tigers (44-45), 6-5 | Tiger Stadium (3-6) | 31-61 | |
| » Starters: Tex Clevenger vs Jim Bunning | Eighth | 29½ out |
| Wednesday, July 24 |
| » Lost to Indians (47-44), 4-3 | Griffith Stadium (14-28) | 31-62 | Lost 2 |
| » Starters: Stan Pitula vs Camilo Pascual | Eighth | 29½ out |
| » Defeated Indians (47-45), 5-4 | Griffith Stadium (15-28) | 32-62 | |
| » Starters: Early Wynn vs Chuck Stobbs | Eighth | 29½ out |
| Thursday, July 25 |
| » Defeated Indians (47-46), 3-2 | Griffith Stadium (16-28) | 33-62 | Won 2 |
| » Starters: Mike Garcia vs Russ Kemmerer | Eighth | 28½ out |
| Friday, July 26 |
| » Defeated Athletics (34-59), 3-2 | Griffith Stadium (17-28) | 34-62 | Won 3 |
| » Starters: Arnie Portocarrero vs Pedro Ramos | Eighth | 27½ out |
| Saturday, July 27 |
| » Defeated Athletics (34-60), 6-5 | Griffith Stadium (18-28) | 35-62 | Won 4 |
| » Starters: Ned Garver vs Tex Clevenger | Eighth | 27½ out |
| Sunday, July 28 |
| » Lost to Athletics (35-60), 6-2 | Griffith Stadium (18-29) | 35-63 | |
| » Starters: Alex Kellner vs Chuck Stobbs | Seventh | 28½ out |
| » Lost to Athletics (36-60), 3-2 | Griffith Stadium (18-30) | 35-64 | Lost 2 |
| » Starters: Ralph Terry vs Camilo Pascual | Seventh | 28½ out |
| Tuesday, July 30 |
| » Lost to White Sox (60-37), 7-1 | Griffith Stadium (18-31) | 35-65 | Lost 3 |
| » Starters: Dick Donovan vs Russ Kemmerer | Eighth | 29½ out |
| Wednesday, July 31 |
| » Lost to White Sox (61-37), 6-5 | Griffith Stadium (18-32) | 35-66 | Lost 4 |
| » Starters: Bob Keegan vs Pedro Ramos | Eighth | 31 out |
| Thursday, August 1 |
| » Defeated White Sox (61-38), 5-4 | Griffith Stadium (19-32) | 36-66 | |
| » Starters: Jack Harshman vs Chuck Stobbs | Seventh | 30½ out |
| Friday, August 2 |
| » Defeated Tigers (50-50), 2-1 | Griffith Stadium (20-32) | 37-66 | Won 2 |
| » Starters: Paul Foytack vs Camilo Pascual | Sixth | 30½ out |
| Saturday, August 3 |
| » Defeated Tigers (50-51), 4-3 | Griffith Stadium (21-32) | 38-66 | Won 3 |
| » Starters: Billy Hoeft vs Russ Kemmerer | Sixth | 30½ out |
| Sunday, August 4 |
| » Defeated Tigers (50-52), 8-4 | Griffith Stadium (22-32) | 39-66 | Won 4 |
| » Starters: Frank Lary vs Pedro Ramos | Sixth | 31 out |
| Tuesday, August 6 |
| » Lost to Yankees (70-35), 4-0 | Yankee Stadium (1-5) | 39-67 | |
| » Starters: Chuck Stobbs vs Bob Turley | Seventh | 31½ out |
| Wednesday, August 7 |
| » Defeated Yankees (70-36), 3-2 | Yankee Stadium (2-5) | 40-67 | |
| » Starters: Camilo Pascual vs Tom Sturdivant | Seventh | 30½ out |
| Thursday, August 8 |
| » Defeated Yankees (70-37), 6-1 | Yankee Stadium (3-5) | 41-67 | Won 2 |
| » Starters: Russ Kemmerer vs Art Ditmar | Seventh | 29½ out |
| Friday, August 9 |
| » Defeated Red Sox (57-50), 8-0 | Fenway Park (4-2) | 42-67 | Won 3 |
| » Starters: Pedro Ramos vs Tom Brewer | Seventh | 28½ out |
| Saturday, August 10 |
| » Lost to Red Sox (58-50), 4-1 | Fenway Park (4-3) | 42-68 | |
| » Starters: Ted Abernathy vs Willard Nixon | Seventh | 29½ out |
| Sunday, August 11 |
| » Lost to Red Sox (59-50), 8-5 | Fenway Park (4-4) | 42-69 | Lost 2 |
| » Starters: Chuck Stobbs vs Bob Porterfield | Sixth | 31 out |
| » Lost to Red Sox (60-50), 4-3 | Fenway Park (4-5) | 42-70 | Lost 3 |
| » Starters: Dick Hyde vs George Susce | Sixth | 31 out |
| Tuesday, August 13 |
| » Lost to Orioles (54-56), 5-3 | Griffith Stadium (22-33) | 42-71 | Lost 4 |
| » Starters: Connie Johnson vs Russ Kemmerer | Eighth | 32 out |
| Wednesday, August 14 |
| » Lost to Orioles (55-56), 4-2 | Griffith Stadium (22-34) | 42-72 | Lost 5 |
| » Starters: Hal Brown vs Pedro Ramos | Eighth | 32 out |
| Friday, August 16 |
| » Defeated Red Sox (61-53), 5-0 | Griffith Stadium (23-34) | 43-72 | |
| » Starters: George Susce vs Chuck Stobbs | Seventh | 31½ out |
| Saturday, August 17 |
| » Defeated Red Sox (61-54), 16-2 | Griffith Stadium (24-34) | 44-72 | Won 2 |
| » Starters: Mike Fornieles vs Russ Kemmerer | Seventh | 31½ out |
| Sunday, August 18 |
| » Defeated Red Sox (61-55), 6-4 | Griffith Stadium (25-34) | 45-72 | Won 3 |
| » Starters: Frank Sullivan vs Pedro Ramos | Seventh | 32 out |
| Tuesday, August 20 |
| » Defeated White Sox (69-48), 5-4 | Comiskey Park I (3-6) | 46-72 | Won 4 |
| » Starters: Dick Hyde vs Jim Wilson | Seventh | 31½ out |
| » Lost to White Sox (70-48), 6-0 | Comiskey Park I (3-7) | 46-73 | |
| » Starters: Chuck Stobbs vs Bob Keegan | Seventh | 31½ out |
| Wednesday, August 21 |
| » Lost to White Sox (71-48), 12-6 | Comiskey Park I (3-8) | 46-74 | Lost 2 |
| » Starters: Russ Kemmerer vs Jim Derrington | Eighth | 31½ out |
| Friday, August 23 |
| » Lost to Tigers (61-60), 13-4 | Tiger Stadium (3-7) | 46-75 | Lost 3 |
| » Starters: Pedro Ramos vs Duke Maas | Eighth | 32 out |
| Saturday, August 24 |
| » Defeated Tigers (61-61), 6-3 | Tiger Stadium (4-7) | 47-75 | |
| » Starters: Tex Clevenger vs Jim Bunning | Seventh | 32 out |
| Sunday, August 25 |
| » Lost to Indians (59-65), 3-2 | Cleveland Stadium (4-6) | 47-76 | |
| » Starters: Chuck Stobbs vs Mike Garcia | Eighth | 32½ out |
| » Lost to Indians (60-65), 6-4 | Cleveland Stadium (4-7) | 47-77 | Lost 2 |
| » Starters: Russ Kemmerer vs Cal McLish | Eighth | 32½ out |
| Tuesday, August 27 |
| » Lost to Athletics (49-77), 3-1 | Municipal Stadium (3-7) | 47-78 | Lost 3 |
| » Starters: Camilo Pascual vs Jack Urban | Eighth | 33 out |
| Wednesday, August 28 |
| » Defeated Athletics (49-78), 3-2 | Municipal Stadium (4-7) | 48-78 | |
| » Starters: Pedro Ramos vs Ralph Terry | Eighth | 33 out |
| Friday, August 30 |
| » Defeated Yankees (82-46), 4-2 | Yankee Stadium (4-5) | 49-78 | Won 2 |
| » Starters: Chuck Stobbs vs Bobby Shantz | Eighth | 32½ out |
| Saturday, August 31 |
| » Defeated Yankees (82-47), 6-5 | Yankee Stadium (5-5) | 50-78 | Won 3 |
| » Starters: Russ Kemmerer vs Art Ditmar | Seventh | 31½ out |
| Sunday, September 1 |
| » Lost to Yankees (83-47), 3-2 | Yankee Stadium (5-6) | 50-79 | |
| » Starters: Tex Clevenger vs Bob Turley | Seventh | 32½ out |
| Monday, September 2 |
| » Lost to Red Sox (69-61), 7-1 | Fenway Park (4-6) | 50-80 | Lost 2 |
| » Starters: Pedro Ramos vs Frank Sullivan | Seventh | 32½ out |
| » Lost to Red Sox (70-61), 8-7 | Fenway Park (4-7) | 50-81 | Lost 3 |
| » Starters: Russ Kemmerer vs Dave Sisler | Seventh | 32½ out |
| » Major-league debuts: Ken Aspromonte (Red Sox) |
| Wednesday, September 4 |
| » Lost to Orioles (65-67), 1-0 | Memorial Stadium (1-6) | 50-82 | Lost 4 |
| » Starters: Camilo Pascual vs Jerry Walker | Seventh | 33 out |
| Thursday, September 5 |
| » Defeated Orioles (65-68), 3-0 | Memorial Stadium (2-6) | 51-82 | |
| » Starters: Chuck Stobbs vs Ray Moore | Sixth | 33 out |
| Friday, September 6 |
| » Defeated Yankees (85-51), 4-3 | Griffith Stadium (26-34) | 52-82 | Won 2 |
| » Starters: Sal Maglie vs Tex Clevenger | Sixth | 32 out |
| Saturday, September 7 |
| » Lost to Yankees (86-51), 4-1 | Griffith Stadium (26-35) | 52-83 | |
| » Starters: Whitey Ford vs Pedro Ramos | Seventh | 33 out |
| Sunday, September 8 |
| » Lost to Yankees (87-51), 5-2 | Griffith Stadium (26-36) | 52-84 | Lost 2 |
| » Starters: Tom Sturdivant vs Russ Kemmerer | Seventh | 34 out |
| Wednesday, September 11 |
| » Lost to Tigers (70-67), 3-0 | Griffith Stadium (26-37) | 52-85 | Lost 3 |
| » Starters: Jim Bunning vs Camilo Pascual | Eighth | 35 out |
| » Lost to Tigers (71-67), 12-2 | Griffith Stadium (26-38) | 52-86 | Lost 4 |
| » Starters: Frank Lary vs Pedro Ramos | Eighth | 35 out |
| » Major-league debuts: George Thomas (Tigers) |
| Thursday, September 12 |
| » Lost to Tigers (72-67), 8-5 | Griffith Stadium (26-39) | 52-87 | Lost 5 |
| » Starters: Duke Maas vs Chuck Stobbs | Eighth | 35½ out |
| Friday, September 13 |
| » Defeated Athletics (52-86), 11-6 | Griffith Stadium (27-39) | 53-87 | |
| » Starters: Alex Kellner vs Russ Kemmerer | Seventh | 35½ out |
| Saturday, September 14 |
| » Defeated Athletics (52-87), 3-2 | Griffith Stadium (28-39) | 54-87 | Won 2 |
| » Starters: Ned Garver vs Ralph Lumenti | Seventh | 34½ out |
| Sunday, September 15 |
| » Lost to White Sox (84-57), 3-1 | Griffith Stadium (28-40) | 54-88 | |
| » Starters: Bob Keegan vs Tex Clevenger | Seventh | 36 out |
| Tuesday, September 17 |
| » Lost to Indians (69-74), 7-3 | Griffith Stadium (28-41) | 54-89 | Lost 2 |
| » Starters: Ray Narleski vs Camilo Pascual | Seventh | 37 out |
| Wednesday, September 18 |
| » Lost to Indians (70-74), 8-3 | Griffith Stadium (28-42) | 54-90 | Lost 3 |
| » Starters: Mike Garcia vs Russ Kemmerer | Sixth | 38 out |
| Thursday, September 19 |
| » Lost to White Sox (86-58), 7-3 | Griffith Stadium (28-43) | 54-91 | Lost 4 |
| » Starters: Bill Fischer vs Chuck Stobbs | Sixth | 38½ out |
| Friday, September 20 |
| » Lost to Orioles (71-74), 1-0 | Memorial Stadium (2-7) | 54-92 | Lost 5 |
| » Starters: Tex Clevenger vs Connie Johnson | Seventh | 39½ out |
| Saturday, September 21 |
| » Defeated Orioles (71-75), 8-1 | Memorial Stadium (3-7) | 55-92 | |
| » Starters: Bob Wiesler vs Ray Moore | Seventh | 38½ out |
| Sunday, September 22 |
| » Lost to Orioles (72-75), 6-5 | Memorial Stadium (3-8) | 55-93 | |
| » Starters: Camilo Pascual vs Art Houtteman | Eighth | 39½ out |
| Monday, September 23 |
| » Lost to Red Sox (79-70), 9-4 | Griffith Stadium (28-44) | 55-94 | Lost 2 |
| » Starters: Mike Fornieles vs Ralph Lumenti | Eighth | 40 out |
| Tuesday, September 24 |
| » Lost to Red Sox (80-70), 2-1 | Griffith Stadium (28-45) | 55-95 | Lost 3 |
| » Starters: Frank Sullivan vs Hal Griggs | Eighth | 40½ out |
| Wednesday, September 25 |
| » Lost to Red Sox (81-70), 7-6 | Griffith Stadium (28-46) | 55-96 | Lost 4 |
| » Starters: Tom Brewer vs Chuck Stobbs | Seventh | 41 out |
| Friday, September 27 |
| » Lost to Orioles (74-76), 7-3 | Griffith Stadium (28-47) | 55-97 | Lost 5 |
| » Starters: Hal Brown vs Bob Wiesler | Eighth | 42 out |
| Saturday, September 28 |
| » Lost to Orioles (75-76), 9-1 | Griffith Stadium (28-48) | 55-98 | Lost 6 |
| » Starters: Bill Wight vs Don Minnick | Eighth | 43 out |
| Sunday, September 29 |
| » Lost to Orioles (76-76), 7-3 | Griffith Stadium (28-49) | 55-99 | Lost 7 |
| » Starters: Connie Johnson vs Hal Griggs | Eighth | 43 out |
| Tuesday, November 19 |
| Former Senator Frank Foreman dies in Baltimore, MD at the age of 95. |
Game information provided by Retrosheet (www.retrosheet.org) |