| Sunday, March 3 |
| Future Red Skeeter Barnes is born in Cincinnati, OH. |
| Wednesday, March 13 |
| Future Red Duane Walker is born in Pasadena, TX. |
| Wednesday, March 20 |
| Former Red Ezra Midkiff dies in Huntington, WV at the age of 75. |
| Monday, April 15 |
| » Major-league debuts: Neil Chrisley (Senators) |
| Tuesday, April 16 |
| » Lost to Cardinals (1-0), 13-4 | Crosley Field (0-1) | 0-1 | |
| » Starters: Herm Wehmeier vs Johnny Klippstein | Second | 1 out |
| » Major-league debuts: Bobby Gene Smith (Cardinals) |
| Thursday, April 18 |
| » Lost to Braves (2-0), 1-0 | County Stadium (0-1) | 0-2 | Lost 2 |
| » Starters: Hal Jeffcoat vs Lew Burdette | Third | 2 out |
| Saturday, April 20 |
| » Lost to Braves (3-0), 5-4 | County Stadium (0-2) | 0-3 | Lost 3 |
| » Starters: Brooks Lawrence vs Ray Crone | Fourth | 3 out |
| » Major-league debuts: Don Pavletich (Reds) |
| Sunday, April 21 |
| » Lost to Braves (4-0), 3-1 | County Stadium (0-3) | 0-4 | Lost 4 |
| » Starters: Johnny Klippstein vs Warren Spahn | Fifth | 4 out |
| Monday, April 22 |
| » Defeated Cardinals (2-3), 10-6 | Sportsman's Park III (1-0) | 1-4 | |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Sixth | 4 out |
| Tuesday, April 23 |
| » Defeated Cardinals (2-4), 6-4 | Sportsman's Park III (2-0) | 2-4 | Won 2 |
| » Starters: Hal Jeffcoat vs Murry Dickson | Fourth | 3 out |
| Wednesday, April 24 |
| » Defeated Cubs (3-4), 9-5 | Crosley Field (1-1) | 3-4 | Won 3 |
| » Starters: Moe Drabowsky vs Joe Nuxhall | Third | 3 out |
| Thursday, April 25 |
| » Defeated Cubs (3-5), 6-3 | Crosley Field (2-1) | 4-4 | Won 4 |
| » Starters: Dick Drott vs Brooks Lawrence | Second | 2½ out |
| Friday, April 26 |
| » Lost to Braves (7-1), 9-2 | Crosley Field (2-2) | 4-5 | |
| » Starters: Warren Spahn vs Johnny Klippstein | Fourth | 3½ out |
| Saturday, April 27 |
| » Lost to Braves (8-1), 5-4 | Crosley Field (2-3) | 4-6 | Lost 2 |
| » Starters: Lew Burdette vs Warren Hacker | Fifth | 4½ out |
| Sunday, April 28 |
| » Lost to Braves (9-1), 3-2 | Crosley Field (2-4) | 4-7 | Lost 3 |
| » Starters: Taylor Phillips vs Tom Acker | Sixth | 5½ out |
| Tuesday, April 30 |
| » Defeated Phillies (5-7), 6-3 | Shibe Park (1-0) | 5-7 | |
| » Starters: Brooks Lawrence vs Harvey Haddix | Fifth | 4½ out |
| Wednesday, May 1 |
| » Defeated Phillies (5-8), 8-6 | Shibe Park (2-0) | 6-7 | Won 2 |
| » Starters: Hal Jeffcoat vs Curt Simmons | Fifth | 4½ out |
| Thursday, May 2 |
| » Defeated Giants (7-8), 9-7 | Polo Grounds V (1-0) | 7-7 | Won 3 |
| » Starters: Johnny Klippstein vs Pete Burnside | Fourth | 4½ out |
| Friday, May 3 |
| » Defeated Giants (7-9), 11-10 | Polo Grounds V (2-0) | 8-7 | Won 4 |
| » Starters: Art Fowler vs Al Worthington | Fourth | 4½ out |
| » Major-league debuts: Bobby Henrich (Reds) |
| Saturday, May 4 |
| » Defeated Giants (7-10), 5-2 | Polo Grounds V (3-0) | 9-7 | Won 5 |
| » Starters: Warren Hacker vs Johnny Antonelli | Third | 3½ out |
| Sunday, May 5 |
| » Defeated Pirates (5-12), 6-2 | Forbes Field (1-0) | 10-7 | Won 6 |
| » Starters: Brooks Lawrence vs Luis Arroyo | Third | 3 out |
| » Defeated Pirates (5-13), 7-3 | Forbes Field (2-0) | 11-7 | Won 7 |
| » Starters: Don Gross vs Bob Purkey | Third | 3 out |
| Tuesday, May 7 |
| » Defeated Dodgers (12-6), 9-2 | Ebbets Field (1-0) | 12-7 | Won 8 |
| » Starters: Hal Jeffcoat vs Johnny Podres | Third | 1½ out |
| Wednesday, May 8 |
| » Defeated Dodgers (12-7), 7-6 | Ebbets Field (2-0) | 13-7 | Won 9 |
| » Starters: Warren Hacker vs Don Newcombe | Second | ½ out |
| Thursday, May 9 |
| Future Red John Stuper is born in Butler, PA. |
| Saturday, May 11 |
| » Defeated Cubs (7-14), 5-4 | Wrigley Field (1-0) | 14-7 | Won 10 |
| » Starters: Brooks Lawrence vs Bob Rush | First | -- |
| Sunday, May 12 |
| » Defeated Cubs (7-15), 7-5 | Wrigley Field (2-0) | 15-7 | Won 11 |
| » Starters: Hal Jeffcoat vs Don Kaiser | First | -- |
| » Defeated Cubs (7-16), 7-1 | Wrigley Field (3-0) | 16-7 | Won 12 |
| » Starters: Don Gross vs Tom Poholsky | First | -- |
| Tuesday, May 14 |
| » Lost to Phillies (14-11), 10-8 | Crosley Field (2-5) | 16-8 | |
| » Starters: Don Cardwell vs Warren Hacker | Second | 1 out |
| Wednesday, May 15 |
| » Defeated Phillies (14-12), 7-2 | Crosley Field (3-5) | 17-8 | |
| » Starters: Jack Sanford vs Brooks Lawrence | First | -- |
| Thursday, May 16 |
| » Defeated Giants (12-16), 3-2 | Crosley Field (4-5) | 18-8 | Won 2 |
| » Starters: Stu Miller vs Hal Jeffcoat | First | -- |
| Friday, May 17 |
| » Defeated Giants (12-17), 11-1 | Crosley Field (5-5) | 19-8 | Won 3 |
| » Starters: Curt Barclay vs Don Gross | First | -- |
| Saturday, May 18 |
| » Lost to Giants (13-17), 6-3 | Crosley Field (5-6) | 19-9 | |
| » Starters: Ruben Gomez vs Joe Nuxhall | First | -- |
| Sunday, May 19 |
| » Defeated Pirates (8-20), 8-7 | Crosley Field (6-6) | 20-9 | |
| » Starters: Luis Arroyo vs Brooks Lawrence | First | -- |
| » Defeated Pirates (8-21), 5-4 | Crosley Field (7-6) | 21-9 | Won 2 |
| » Starters: Ron Kline vs Warren Hacker | First | -- |
| Tuesday, May 21 |
| » Lost to Dodgers (18-10), 6-1 | Crosley Field (7-7) | 21-10 | |
| » Starters: Johnny Podres vs Hal Jeffcoat | First | -- |
| Wednesday, May 22 |
| » Defeated Dodgers (18-11), 8-1 | Crosley Field (8-7) | 22-10 | |
| » Starters: Sandy Koufax vs Johnny Klippstein | First | -- |
| Thursday, May 23 |
| » Defeated Cardinals (13-17), 6-2 | Crosley Field (9-7) | 23-10 | Won 2 |
| » Starters: Lindy McDaniel vs Don Gross | First | -- |
| Friday, May 24 |
| » Lost to Cardinals (14-17), 9-6 | Crosley Field (9-8) | 23-11 | |
| » Starters: Sam Jones vs Joe Nuxhall | First | -- |
| Saturday, May 25 |
| » Lost to Cardinals (15-17), 12-4 | Crosley Field (9-9) | 23-12 | Lost 2 |
| » Starters: Willard Schmidt vs Brooks Lawrence | First | -- |
| Sunday, May 26 |
| » Defeated Cardinals (15-18), 7-6 | Crosley Field (10-9) | 24-12 | |
| » Starters: Murry Dickson vs Hal Jeffcoat | First | -- |
| Monday, May 27 |
| » Defeated Braves (20-14), 11-6 | County Stadium (1-3) | 25-12 | Won 2 |
| » Starters: Johnny Klippstein vs Lew Burdette | First | -- |
| Tuesday, May 28 |
| » Lost to Braves (21-14), 1-0 | County Stadium (1-4) | 25-13 | |
| » Starters: Don Gross vs Warren Spahn | First | -- |
| Thursday, May 30 |
| » Lost to Cardinals (18-18), 7-2 | Sportsman's Park III (2-1) | 25-14 | Lost 2 |
| » Starters: Joe Nuxhall vs Willard Schmidt | First | -- |
| » Defeated Cardinals (18-19), 7-3 | Sportsman's Park III (3-1) | 26-14 | |
| » Starters: Brooks Lawrence vs Vinegar Bend Mizell | First | -- |
| Saturday, June 1 |
| » Defeated Cubs (12-25), 22-2 | Crosley Field (11-9) | 27-14 | Won 2 |
| » Starters: Dick Littlefield vs Hal Jeffcoat | First | -- |
| Former Red Pete Schneider dies in Los Angeles, CA at the age of 62. |
| Sunday, June 2 |
| » Defeated Cubs (12-26), 6-4 | Crosley Field (12-9) | 28-14 | Won 3 |
| » Starters: Moe Drabowsky vs Don Gross | First | -- |
| » Lost to Cubs (13-26), 4-2 | Crosley Field (12-10) | 28-15 | |
| » Starters: Bob Rush vs Johnny Klippstein | First | -- |
| Tuesday, June 4 |
| » Lost to Phillies (26-18), 3-1 | Shibe Park (2-1) | 28-16 | Lost 2 |
| » Starters: Brooks Lawrence vs Harvey Haddix | First | -- |
| Wednesday, June 5 |
| » Defeated Phillies (26-19), 4-2 | Shibe Park (3-1) | 29-16 | |
| » Starters: Hal Jeffcoat vs Curt Simmons | First | -- |
| Thursday, June 6 |
| » Lost to Phillies (27-19), 6-2 | Shibe Park (3-2) | 29-17 | |
| » Starters: Don Gross vs Robin Roberts | First | -- |
| Future Red Max Venable is born in Phoenix, AZ. |
| Friday, June 7 |
| » Lost to Dodgers (27-17), 6-3 | Ebbets Field (2-1) | 29-18 | Lost 2 |
| » Starters: Johnny Klippstein vs Roger Craig | First | -- |
| Saturday, June 8 |
| » Lost to Dodgers (28-17), 9-2 | Ebbets Field (2-2) | 29-19 | Lost 3 |
| » Starters: Warren Hacker vs Johnny Podres | Second | 1½ out |
| Sunday, June 9 |
| » Defeated Dodgers (28-18), 3-1 | Ebbets Field (3-2) | 30-19 | |
| » Starters: Brooks Lawrence vs Don Drysdale | First | -- |
| » Defeated Dodgers (28-19), 3-0 | Ebbets Field (4-2) | 31-19 | Won 2 |
| » Starters: Hal Jeffcoat vs Ed Roebuck | First | -- |
| Monday, June 10 |
| » Lost to Pirates (17-32), 5-2 | Forbes Field (2-1) | 31-20 | |
| » Starters: Joe Nuxhall vs Vern Law | First | -- |
| Tuesday, June 11 |
| » Lost to Pirates (18-32), 8-1 | Forbes Field (2-2) | 31-21 | Lost 2 |
| » Starters: Don Gross vs Bob Purkey | First | -- |
| Wednesday, June 12 |
| » Lost to Pirates (19-32), 4-3 | Forbes Field (2-3) | 31-22 | Lost 3 |
| » Starters: Johnny Klippstein vs Luis Arroyo | First | -- |
| Thursday, June 13 |
| » Lost to Pirates (20-32), 3-2 | Forbes Field (2-4) | 31-23 | Lost 4 |
| » Starters: Hal Jeffcoat vs Bob Friend | Second | 1½ out |
| Friday, June 14 |
| » Defeated Giants (24-32), 5-4 | Polo Grounds V (4-0) | 32-23 | |
| » Starters: Joe Nuxhall vs Stu Miller | Second | 1½ out |
| Saturday, June 15 |
| » Lost to Giants (25-32), 8-4 | Polo Grounds V (4-1) | 32-24 | |
| » Starters: Brooks Lawrence vs Ruben Gomez | Second | 1½ out |
| Sunday, June 16 |
| » Lost to Giants (26-32), 4-3 | Polo Grounds V (4-2) | 32-25 | Lost 2 |
| » Starters: Don Gross vs Ray Crone | Third | 2 out |
| Monday, June 17 |
| » Lost to Dodgers (31-25), 7-2 | Crosley Field (12-11) | 32-26 | Lost 3 |
| » Starters: Danny McDevitt vs Johnny Klippstein | Fourth | 2 out |
| » Major-league debuts: Danny McDevitt (Dodgers) |
| Tuesday, June 18 |
| » Lost to Dodgers (32-25), 7-0 | Crosley Field (12-12) | 32-27 | Lost 4 |
| » Starters: Don Newcombe vs Hal Jeffcoat | Fifth | 2 out |
| Wednesday, June 19 |
| » Defeated Dodgers (32-26), 4-3 | Crosley Field (13-12) | 33-27 | |
| » Starters: Don Drysdale vs Tom Acker | Fourth | 2 out |
| Thursday, June 20 |
| » Defeated Dodgers (32-27), 6-1 | Crosley Field (14-12) | 34-27 | Won 2 |
| » Starters: Roger Craig vs Brooks Lawrence | Third | 1½ out |
| Friday, June 21 |
| » Lost to Pirates (24-38), 3-2 | Crosley Field (14-13) | 34-28 | |
| » Starters: Bob Friend vs Joe Nuxhall | Fourth | 2½ out |
| Saturday, June 22 |
| » Defeated Pirates (24-39), 6-3 | Crosley Field (15-13) | 35-28 | |
| » Starters: Vern Law vs Don Gross | Third | 1½ out |
| Sunday, June 23 |
| » Defeated Pirates (24-40), 5-3 | Crosley Field (16-13) | 36-28 | Won 2 |
| » Starters: Red Swanson vs Hal Jeffcoat | Third | 2 out |
| » Defeated Pirates (24-41), 5-2 | Crosley Field (17-13) | 37-28 | Won 3 |
| » Starters: Ron Kline vs Tom Acker | Third | 2 out |
| Tuesday, June 25 |
| » Defeated Giants (31-35), 3-2 | Crosley Field (18-13) | 38-28 | Won 4 |
| » Starters: Ray Crone vs Brooks Lawrence | Second | 2 out |
| Wednesday, June 26 |
| » Lost to Giants (32-35), 17-7 | Crosley Field (18-14) | 38-29 | |
| » Starters: Ruben Gomez vs Joe Nuxhall | Second | 2 out |
| Thursday, June 27 |
| » Lost to Giants (33-35), 7-2 | Crosley Field (18-15) | 38-30 | Lost 2 |
| » Starters: Johnny Antonelli vs Don Gross | Third | 2 out |
| Friday, June 28 |
| » Defeated Phillies (36-31), 7-1 | Crosley Field (19-15) | 39-30 | |
| » Starters: Don Cardwell vs Hal Jeffcoat | Third | ½ out |
| Saturday, June 29 |
| » Defeated Phillies (36-32), 8-3 | Crosley Field (20-15) | 40-30 | Won 2 |
| » Starters: Robin Roberts vs Tom Acker | Second | ½ out |
| Sunday, June 30 |
| » Defeated Phillies (36-33), 6-1 | Crosley Field (21-15) | 41-30 | Won 3 |
| » Starters: Curt Simmons vs Brooks Lawrence | Second | ½ out |
| » Defeated Phillies (36-34), 6-2 | Crosley Field (22-15) | 42-30 | Won 4 |
| » Starters: Harvey Haddix vs Johnny Klippstein | Second | ½ out |
| Monday, July 1 |
| » Lost to Cubs (23-42), 6-0 | Wrigley Field (3-1) | 42-31 | |
| » Starters: Joe Nuxhall vs Dick Drott | Second | ½ out |
| Tuesday, July 2 |
| » Defeated Cubs (23-43), 8-6 | Wrigley Field (4-1) | 43-31 | |
| » Starters: Don Gross vs Don Kaiser | First | -- |
| Wednesday, July 3 |
| » Defeated Braves (42-32), 7-5 | Crosley Field (23-15) | 44-31 | Won 2 |
| » Starters: Lew Burdette vs Hal Jeffcoat | First | -- |
| Former Red Dolf Luque dies in Havana, Cuba at the age of 67. |
| Thursday, July 4 |
| » Lost to Braves (43-32), 10-7 | Crosley Field (23-16) | 44-32 | |
| » Starters: Taylor Phillips vs Tom Acker | First | -- |
| Friday, July 5 |
| » Lost to Cardinals (43-31), 4-3 | Sportsman's Park III (3-2) | 44-33 | Lost 2 |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Second | 1½ out |
| Saturday, July 6 |
| » Lost to Cardinals (44-31), 13-3 | Sportsman's Park III (3-3) | 44-34 | Lost 3 |
| » Starters: Johnny Klippstein vs Murry Dickson | Second | 1½ out |
| » Major-league debuts: Claude Osteen (Reds) |
| Sunday, July 7 |
| » Lost to Cardinals (45-31), 3-2 | Sportsman's Park III (3-4) | 44-35 | Lost 4 |
| » Starters: Brooks Lawrence vs Von McDaniel | Third | 3½ out |
| » Lost to Cardinals (46-31), 9-6 | Sportsman's Park III (3-5) | 44-36 | Lost 5 |
| » Starters: Hal Jeffcoat vs Larry Jackson | Third | 3½ out |
| Thursday, July 11 |
| » Lost to Dodgers (42-36), 5-4 | Ebbets Field (4-3) | 44-37 | Lost 6 |
| » Starters: Brooks Lawrence vs Danny McDevitt | Fourth | 3½ out |
| Friday, July 12 |
| » Lost to Dodgers (43-36), 3-1 | Roosevelt Stadium (0-1) | 44-38 | Lost 7 |
| » Starters: Johnny Klippstein vs Don Newcombe | Fifth | 4½ out |
| Sunday, July 14 |
| » Defeated Pirates (31-53), 9-6 | Forbes Field (3-4) | 45-38 | |
| » Starters: Art Fowler vs Red Swanson | Fourth | 2½ out |
| » Defeated Pirates (31-54), 12-4 | Forbes Field (4-4) | 46-38 | Won 2 |
| » Starters: Joe Nuxhall vs Joe Trimble | Fourth | 2½ out |
| Tuesday, July 16 |
| » Lost to Giants (41-44), 6-1 | Polo Grounds V (4-3) | 46-39 | |
| » Starters: Hal Jeffcoat vs Ruben Gomez | Fourth | 2 out |
| Wednesday, July 17 |
| » Defeated Giants (41-45), 5-4 | Polo Grounds V (5-3) | 47-39 | |
| » Starters: Brooks Lawrence vs Curt Barclay | Fifth | 2 out |
| Thursday, July 18 |
| » Defeated Giants (41-46), 2-1 | Polo Grounds V (6-3) | 48-39 | Won 2 |
| » Starters: Johnny Klippstein vs Stu Miller | Fourth | 2 out |
| Friday, July 19 |
| » Defeated Phillies (48-40), 7-2 | Shibe Park (4-2) | 49-39 | Won 3 |
| » Starters: Joe Nuxhall vs Jack Sanford | Fourth | 2 out |
| Saturday, July 20 |
| » Lost to Phillies (49-40), 7-5 | Shibe Park (4-3) | 49-40 | |
| » Starters: Hal Jeffcoat vs Jim Hearn | Fourth | 3 out |
| Sunday, July 21 |
| » Defeated Phillies (49-41), 4-2 | Shibe Park (5-3) | 50-40 | |
| » Starters: Brooks Lawrence vs Robin Roberts | Third | 2 out |
| » Defeated Phillies (49-42), 6-4 | Shibe Park (6-3) | 51-40 | Won 2 |
| » Starters: Art Fowler vs Harvey Haddix | Third | 2 out |
| Tuesday, July 23 |
| » Lost to Pirates (35-58), 6-3 | Crosley Field (23-17) | 51-41 | |
| » Starters: Vern Law vs Johnny Klippstein | Fourth | 3 out |
| Wednesday, July 24 |
| » Defeated Pirates (35-59), 2-0 | Crosley Field (24-17) | 52-41 | |
| » Starters: Bob Friend vs Joe Nuxhall | Third | 2 out |
| Thursday, July 25 |
| » Defeated Pirates (35-60), 9-1 | Crosley Field (25-17) | 53-41 | Won 2 |
| » Starters: Ron Kline vs Art Fowler | Fourth | 1 out |
| Friday, July 26 |
| » Defeated Dodgers (52-41), 6-5 | Crosley Field (26-17) | 54-41 | Won 3 |
| » Starters: Sandy Koufax vs Hal Jeffcoat | Third | 1 out |
| Saturday, July 27 |
| » Lost to Dodgers (53-41), 5-3 | Crosley Field (26-18) | 54-42 | |
| » Starters: Danny McDevitt vs Johnny Klippstein | Fourth | 2 out |
| Sunday, July 28 |
| » Lost to Dodgers (54-41), 7-2 | Crosley Field (26-19) | 54-43 | Lost 2 |
| » Starters: Johnny Podres vs Brooks Lawrence | Fourth | 2½ out |
| Tuesday, July 30 |
| » Lost to Phillies (56-44), 8-5 | Crosley Field (26-20) | 54-44 | Lost 3 |
| » Starters: Warren Hacker vs Joe Nuxhall | Fifth | 4 out |
| Future Red Clint Hurdle is born in Big Rapids, MI. |
| Wednesday, July 31 |
| » Defeated Phillies (56-45), 6-5 | Crosley Field (27-20) | 55-44 | |
| » Starters: Harvey Haddix vs Vicente Amor | Fourth | 4 out |
| Future Red Leon Durham is born in Cincinnati, OH. |
| Thursday, August 1 |
| » Defeated Phillies (56-46), 4-3 | Crosley Field (28-20) | 56-44 | Won 2 |
| » Starters: Curt Simmons vs Brooks Lawrence | Fourth | 4 out |
| Friday, August 2 |
| » Defeated Giants (44-59), 9-6 | Crosley Field (29-20) | 57-44 | Won 3 |
| » Starters: Curt Barclay vs Hal Jeffcoat | Fourth | 4 out |
| Saturday, August 3 |
| » Lost to Giants (45-59), 5-4 | Crosley Field (29-21) | 57-45 | |
| » Starters: Ruben Gomez vs Art Fowler | Fourth | 5 out |
| Sunday, August 4 |
| » Lost to Giants (46-59), 7-6 | Crosley Field (29-22) | 57-46 | Lost 2 |
| » Starters: Mike McCormick vs Joe Nuxhall | Fourth | 5 out |
| » Defeated Giants (46-60), 3-2 | Crosley Field (30-22) | 58-46 | |
| » Starters: Stu Miller vs Vicente Amor | Fourth | 5 out |
| Future Red Ben Hayes is born in Niagara Falls, NY. |
| Tuesday, August 6 |
| » Lost to Braves (63-42), 5-4 | County Stadium (1-5) | 58-47 | |
| » Starters: Hal Jeffcoat vs Warren Spahn | Third | 5 out |
| Wednesday, August 7 |
| » Lost to Braves (64-42), 12-2 | County Stadium (1-6) | 58-48 | Lost 2 |
| » Starters: Brooks Lawrence vs Gene Conley | Fourth | 6 out |
| Thursday, August 8 |
| » Lost to Braves (65-42), 5-3 | County Stadium (1-7) | 58-49 | Lost 3 |
| » Starters: Joe Nuxhall vs Lew Burdette | Fourth | 7 out |
| Friday, August 9 |
| » Defeated Cubs (39-67), 9-7 | Crosley Field (31-22) | 59-49 | |
| » Starters: Jim Brosnan vs Vicente Amor | Fourth | 6½ out |
| » Defeated Cubs (39-68), 6-4 | Crosley Field (32-22) | 60-49 | Won 2 |
| » Starters: Don Elston vs Art Fowler | Fourth | 6½ out |
| Saturday, August 10 |
| » Defeated Cubs (39-69), 7-2 | Crosley Field (33-22) | 61-49 | Won 3 |
| » Starters: Dave Hillman vs Hal Jeffcoat | Fourth | 6½ out |
| Tuesday, August 13 |
| » Lost to Braves (69-42), 12-4 | Crosley Field (33-23) | 61-50 | |
| » Starters: Lew Burdette vs Joe Nuxhall | Fourth | 8 out |
| Wednesday, August 14 |
| » Lost to Braves (70-42), 13-3 | Crosley Field (33-24) | 61-51 | Lost 2 |
| » Starters: Bob Buhl vs Brooks Lawrence | Fourth | 9 out |
| Thursday, August 15 |
| » Lost to Braves (71-42), 8-1 | Crosley Field (33-25) | 61-52 | Lost 3 |
| » Starters: Warren Spahn vs Hal Jeffcoat | Fourth | 10 out |
| Friday, August 16 |
| » Lost to Cubs (43-69), 8-6 | Wrigley Field (4-2) | 61-53 | Lost 4 |
| » Starters: Art Fowler vs Don Elston | Fourth | 10 out |
| Saturday, August 17 |
| » Lost to Cubs (44-69), 2-1 | Wrigley Field (4-3) | 61-54 | Lost 5 |
| » Starters: Hal Jeffcoat vs Dave Hillman | Fourth | 11 out |
| Future Red Bill Landrum is born in Columbia, SC. |
| Sunday, August 18 |
| » Lost to Cubs (45-69), 8-2 | Wrigley Field (4-4) | 61-55 | Lost 6 |
| » Starters: Joe Nuxhall vs Bob Rush | Fourth | 10½ out |
| Tuesday, August 20 |
| » Lost to Dodgers (66-53), 11-5 | Ebbets Field (4-4) | 61-56 | Lost 7 |
| » Starters: Tom Acker vs Johnny Podres | Fourth | 12 out |
| » Lost to Dodgers (67-53), 6-5 | Ebbets Field (4-5) | 61-57 | Lost 8 |
| » Starters: Brooks Lawrence vs Danny McDevitt | Fourth | 12 out |
| Wednesday, August 21 |
| » Lost to Dodgers (68-53), 8-0 | Ebbets Field (4-6) | 61-58 | Lost 9 |
| » Starters: Hal Jeffcoat vs Don Newcombe | Fourth | 12½ out |
| Future Red Frank Pastore is born in Alhambra, CA. |
| Thursday, August 22 |
| » Lost to Pirates (44-75), 8-3 | Forbes Field (4-5) | 61-59 | Lost 10 |
| » Starters: Don Gross vs Bob Friend | Fourth | 13½ out |
| Friday, August 23 |
| » Defeated Pirates (44-76), 6-0 | Forbes Field (5-5) | 62-59 | |
| » Starters: Joe Nuxhall vs Bob Purkey | Fourth | 12½ out |
| Saturday, August 24 |
| » Lost to Pirates (45-76), 4-1 | Forbes Field (5-6) | 62-60 | |
| » Starters: Brooks Lawrence vs Ron Kline | Fourth | 13½ out |
| Sunday, August 25 |
| » Lost to Giants (60-67), 10-1 | Polo Grounds V (6-4) | 62-61 | Lost 2 |
| » Starters: Hal Jeffcoat vs Ruben Gomez | Fourth | 14½ out |
| Monday, August 26 |
| » Lost to Giants (61-67), 17-3 | Polo Grounds V (6-5) | 62-62 | Lost 3 |
| » Starters: Vicente Amor vs Ray Crone | Fifth | 14½ out |
| Future Red Alex Trevino is born in Monterrey, Mexico. |
| Tuesday, August 27 |
| » Defeated Phillies (63-62), 5-2 | Shibe Park (7-3) | 63-62 | |
| » Starters: Joe Nuxhall vs Don Cardwell | Fourth | 14½ out |
| Wednesday, August 28 |
| » Defeated Phillies (63-63), 6-5 | Shibe Park (8-3) | 64-62 | Won 2 |
| » Starters: Brooks Lawrence vs Curt Simmons | Fourth | 13½ out |
| Friday, August 30 |
| » Lost to Braves (78-48), 9-5 | Crosley Field (33-26) | 64-63 | |
| » Starters: Warren Spahn vs Bud Podbielan | Fourth | 14½ out |
| Saturday, August 31 |
| » Lost to Braves (79-48), 14-4 | Crosley Field (33-27) | 64-64 | Lost 2 |
| » Starters: Lew Burdette vs Joe Nuxhall | Fifth | 15½ out |
| Sunday, September 1 |
| » Defeated Braves (79-49), 6-0 | Crosley Field (34-27) | 65-64 | |
| » Starters: Gene Conley vs Brooks Lawrence | Fifth | 14½ out |
| Monday, September 2 |
| » Defeated Cardinals (73-57), 10-5 | Crosley Field (35-27) | 66-64 | Won 2 |
| » Starters: Von McDaniel vs Hal Jeffcoat | Fifth | 14½ out |
| » Defeated Cardinals (73-58), 3-1 | Crosley Field (36-27) | 67-64 | Won 3 |
| » Starters: Larry Jackson vs Don Gross | Fifth | 14½ out |
| Tuesday, September 3 |
| » Lost to Cardinals (74-58), 14-4 | Crosley Field (36-28) | 67-65 | |
| » Starters: Vinegar Bend Mizell vs Joe Nuxhall | Fifth | 15½ out |
| » Major-league debuts: Jay Hook (Reds) |
| Wednesday, September 4 |
| » Lost to Cubs (50-80), 1-0 | Wrigley Field (4-5) | 67-66 | Lost 2 |
| » Starters: Bud Podbielan vs Moe Drabowsky | Fifth | 15 out |
| » Defeated Cubs (50-81), 7-2 | Wrigley Field (5-5) | 68-66 | |
| » Starters: Joe Nuxhall vs Don Elston | Fifth | 15 out |
| Thursday, September 5 |
| » Defeated Cubs (50-82), 4-1 | Wrigley Field (6-5) | 69-66 | Won 2 |
| » Starters: Brooks Lawrence vs Dick Drott | Fourth | 14 out |
| Friday, September 6 |
| » Defeated Cardinals (76-59), 5-4 | Sportsman's Park III (4-5) | 70-66 | Won 3 |
| » Starters: Don Gross vs Larry Jackson | Fourth | 13 out |
| Saturday, September 7 |
| » Lost to Cardinals (77-59), 7-4 | Sportsman's Park III (4-6) | 70-67 | |
| » Starters: Hal Jeffcoat vs Von McDaniel | Fourth | 14 out |
| Sunday, September 8 |
| » Lost to Cardinals (78-59), 4-3 | Sportsman's Park III (4-7) | 70-68 | Lost 2 |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Fourth | 14 out |
| Monday, September 9 |
| Former Red Ed Karger dies in Delta, CO at the age of 75. |
| Tuesday, September 10 |
| » Defeated Giants (67-75), 4-1 | Crosley Field (37-28) | 71-68 | |
| » Starters: Johnny Antonelli vs Brooks Lawrence | Fourth | 14 out |
| Friday, September 13 |
| » Defeated Phillies (70-72), 8-7 | Crosley Field (38-28) | 72-68 | Won 2 |
| » Starters: Jack Sanford vs Joe Nuxhall | Fourth | 13 out |
| Saturday, September 14 |
| » Lost to Phillies (71-72), 5-0 | Crosley Field (38-29) | 72-69 | |
| » Starters: Robin Roberts vs Brooks Lawrence | Fourth | 13 out |
| Sunday, September 15 |
| » Defeated Dodgers (80-64), 11-6 | Crosley Field (39-29) | 73-69 | |
| » Starters: Don Newcombe vs Hal Jeffcoat | Fourth | 12 out |
| Monday, September 16 |
| » Defeated Dodgers (80-65), 3-2 | Crosley Field (40-29) | 74-69 | Won 2 |
| » Starters: Johnny Podres vs Johnny Klippstein | Fourth | 12 out |
| Tuesday, September 17 |
| » Defeated Pirates (58-89), 9-5 | Crosley Field (41-29) | 75-69 | Won 3 |
| » Starters: Bob Friend vs Joe Nuxhall | Fourth | 12 out |
| Wednesday, September 18 |
| » Defeated Pirates (58-90), 2-1 | Crosley Field (42-29) | 76-69 | Won 4 |
| » Starters: Bob Smith vs Brooks Lawrence | Fourth | 12 out |
| Friday, September 20 |
| » Lost to Cardinals (85-61), 7-5 | Crosley Field (42-30) | 76-70 | |
| » Starters: Vinegar Bend Mizell vs Don Gross | Fourth | 13 out |
| Saturday, September 21 |
| » Defeated Cardinals (85-62), 9-8 | Crosley Field (43-30) | 77-70 | |
| » Starters: Sam Jones vs Joe Nuxhall | Fourth | 13 out |
| » Major-league debuts: Charlie Rabe (Reds) |
| Sunday, September 22 |
| » Lost to Cardinals (86-62), 7-5 | Crosley Field (43-31) | 77-71 | |
| » Starters: Lindy McDaniel vs Brooks Lawrence | Fourth | 14 out |
| » Major-league debuts: Bobby Durnbaugh (Reds) Frank Barnes (Cardinals) |
| Tuesday, September 24 |
| » Defeated Cubs (58-91), 4-3 | Crosley Field (44-31) | 78-71 | |
| » Starters: Don Kaiser vs Hal Jeffcoat | Fourth | 14 out |
| » Defeated Cubs (58-92), 11-9 | Crosley Field (45-31) | 79-71 | Won 2 |
| » Starters: Dave Hillman vs Bud Podbielan | Fourth | 14 out |
| Wednesday, September 25 |
| » Lost to Cubs (59-92), 7-5 | Crosley Field (45-32) | 79-72 | |
| » Starters: Moe Drabowsky vs Jay Hook | Fourth | 14 out |
| » Major-league debuts: Dutch Dotterer and Dave Skaugstad (Reds) |
| Friday, September 27 |
| » Lost to Braves (94-58), 2-1 | County Stadium (1-8) | 79-73 | Lost 2 |
| » Starters: Charlie Rabe vs Lew Burdette | Fourth | 15 out |
| Saturday, September 28 |
| » Defeated Braves (94-59), 6-0 | County Stadium (2-8) | 80-73 | |
| » Starters: Johnny Klippstein vs Warren Spahn | Fourth | 14 out |
| Sunday, September 29 |
| » Lost to Braves (95-59), 4-3 | County Stadium (2-9) | 80-74 | |
| » Starters: Jay Hook vs Bob Buhl | Fourth | 15 out |
| Sunday, October 6 |
| Former Red Billy Campbell dies in Cincinnati, OH at the age of 84. |
| Tuesday, October 22 |
| Future Red Jeff Jones is born in Philadelphia, PA. |
| Wednesday, October 30 |
| Former Red Fred Beebe dies |
