| Tuesday, March 5 |
| Future Indian Jerry Ujdur is born in Duluth, MN. |
| Friday, March 8 |
| Future Indian John Butcher is born in Glendale, CA. |
| Monday, April 15 |
| » Major-league debuts: Neil Chrisley (Senators) |
| Former Indian Ernie Padgett dies in E.Orange, NJ at the age of 59. |
| Tuesday, April 16 |
| » Lost to White Sox (1-0), 3-2 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Billy Pierce vs Herb Score | Third | 1 out |
| » Major-league debuts: Roger Maris and Larry Raines (Indians) Jim Landis (White Sox) |
| Thursday, April 18 |
| » Defeated Tigers (0-3), 8-3 | Tiger Stadium (1-0) | 1-1 | |
| » Starters: Bob Lemon vs Billy Hoeft | Third | 1 out |
| Saturday, April 20 |
| » Lost to Tigers (1-3), 7-0 | Tiger Stadium (1-1) | 1-2 | |
| » Starters: Early Wynn vs Frank Lary | Third | 2 out |
| » Major-league debuts: Russ Nixon (Indians) |
| Sunday, April 21 |
| » Lost to Tigers (2-3), 3-2 | Tiger Stadium (1-2) | 1-3 | Lost 2 |
| » Starters: Mike Garcia vs Steve Gromek | Seventh | 3 out |
| Future Indian Jesse Orosco is born in Santa Barbara, CA. |
| Tuesday, April 23 |
| » Defeated White Sox (4-1), 5-0 | Comiskey Park I (1-0) | 2-3 | |
| » Starters: Herb Score vs Billy Pierce | Sixth | 2 out |
| Wednesday, April 24 |
| » Lost to Athletics (5-3), 17-6 | Municipal Stadium (0-1) | 2-4 | |
| » Starters: Bob Lemon vs Ned Garver | Sixth | 2½ out |
| Thursday, April 25 |
| » Defeated Athletics (5-4), 5-3 | Municipal Stadium (1-1) | 3-4 | |
| » Starters: Early Wynn vs Wally Burnette | Fifth | 2½ out |
| Friday, April 26 |
| » Lost to Tigers (3-6), 5-0 | Cleveland Stadium (0-2) | 3-5 | |
| » Starters: Frank Lary vs Bob Lemon | Sixth | 3½ out |
| Saturday, April 27 |
| » Defeated Tigers (3-7), 2-1 | Cleveland Stadium (1-2) | 4-5 | |
| » Starters: Paul Foytack vs Herb Score | Sixth | 2½ out |
| Future Indian Willie Upshaw is born in Blanco, TX. |
| Sunday, April 28 |
| » Lost to Tigers (4-7), 2-0 | Cleveland Stadium (1-3) | 4-6 | |
| » Starters: Don Lee vs Early Wynn | Sixth | 3 out |
| » Defeated Tigers (4-8), 3-2 | Cleveland Stadium (2-3) | 5-6 | |
| » Starters: Billy Hoeft vs Mike Garcia | Sixth | 3 out |
| Tuesday, April 30 |
| » Defeated Senators (5-10), 5-1 | Cleveland Stadium (3-3) | 6-6 | Won 2 |
| » Starters: Pedro Ramos vs Bob Lemon | Fourth | 3 out |
| Wednesday, May 1 |
| » Defeated Senators (5-11), 7-6 | Cleveland Stadium (4-3) | 7-6 | Won 3 |
| » Starters: Camilo Pascual vs Herb Score | Fourth | 3 out |
| Saturday, May 4 |
| » Defeated Red Sox (8-8), 5-2 | Cleveland Stadium (5-3) | 8-6 | Won 4 |
| » Starters: Dean Stone vs Early Wynn | Third | 3 out |
| Sunday, May 5 |
| » Lost to Red Sox (9-8), 5-1 | Cleveland Stadium (5-4) | 8-7 | |
| » Starters: Willard Nixon vs Bob Lemon | Fourth | 3½ out |
| » Lost to Red Sox (10-8), 4-3 | Cleveland Stadium (5-5) | 8-8 | Lost 2 |
| » Starters: Dave Sisler vs Mike Garcia | Fourth | 3½ out |
| Tuesday, May 7 |
| » Defeated Yankees (12-6), 2-1 | Cleveland Stadium (6-5) | 9-8 | |
| » Starters: Tom Sturdivant vs Herb Score | Fifth | 2½ out |
| Wednesday, May 8 |
| » Defeated Yankees (12-7), 10-4 | Cleveland Stadium (7-5) | 10-8 | Won 2 |
| » Starters: Art Ditmar vs Early Wynn | Fourth | 1½ out |
| Friday, May 10 |
| » Defeated Athletics (11-11), 4-1 | Cleveland Stadium (8-5) | 11-8 | Won 3 |
| » Starters: Gene Host vs Mike Garcia | Third | 1½ out |
| Saturday, May 11 |
| » Defeated Athletics (11-12), 2-1 | Cleveland Stadium (9-5) | 12-8 | Won 4 |
| » Starters: Tom Morgan vs Bob Lemon | Third | 1 out |
| Sunday, May 12 |
| » Lost to Athletics (12-12), 9-2 | Cleveland Stadium (9-6) | 12-9 | |
| » Starters: Mickey McDermott vs Early Wynn | Third | 1½ out |
| » Defeated Athletics (12-13), 7-4 | Cleveland Stadium (10-6) | 13-9 | |
| » Starters: Ryne Duren vs Bud Daley | Third | 1½ out |
| Wednesday, May 15 |
| » Defeated Orioles (9-15), 11-8 | Memorial Stadium (1-0) | 14-9 | Won 2 |
| » Starters: Bob Lemon vs Connie Johnson | Third | 1½ out |
| Thursday, May 16 |
| » Defeated Orioles (9-16), 4-3 | Memorial Stadium (2-0) | 15-9 | Won 3 |
| » Starters: Early Wynn vs Ray Moore | Third | 1½ out |
| Friday, May 17 |
| » Defeated Senators (8-22), 3-1 | Griffith Stadium (1-0) | 16-9 | Won 4 |
| » Starters: Bud Daley vs Camilo Pascual | Second | 1½ out |
| Saturday, May 18 |
| » Defeated Senators (8-23), 8-1 | Griffith Stadium (2-0) | 17-9 | Won 5 |
| » Starters: Mike Garcia vs Ted Abernathy | Second | 1 out |
| Sunday, May 19 |
| » Lost to Yankees (17-10), 6-3 | Yankee Stadium (0-1) | 17-10 | |
| » Starters: Bob Lemon vs Bobby Shantz | Second | 2 out |
| Tuesday, May 21 |
| » Defeated Red Sox (15-16), 8-2 | Fenway Park (1-0) | 18-10 | |
| » Starters: Early Wynn vs Dave Sisler | Second | 2 out |
| Wednesday, May 22 |
| » Lost to Red Sox (16-16), 11-0 | Fenway Park (1-1) | 18-11 | |
| » Starters: Bud Daley vs Tom Brewer | Second | 3 out |
| Friday, May 24 |
| » Defeated White Sox (20-8), 4-3 | Cleveland Stadium (11-6) | 19-11 | |
| » Starters: Jack Harshman vs Bob Lemon | Second | 2 out |
| Saturday, May 25 |
| » Lost to White Sox (21-8), 4-0 | Cleveland Stadium (11-7) | 19-12 | |
| » Starters: Dick Donovan vs Early Wynn | Second | 3 out |
| Sunday, May 26 |
| » Lost to White Sox (22-8), 1-0 | Cleveland Stadium (11-8) | 19-13 | Lost 2 |
| » Starters: Billy Pierce vs Bud Daley | Second | 3 out |
| » Defeated White Sox (22-9), 4-3 | Cleveland Stadium (12-8) | 20-13 | |
| » Starters: Jack Harshman vs Dick Tomanek | Second | 3 out |
| Monday, May 27 |
| » Lost to Tigers (18-18), 11-5 | Tiger Stadium (1-3) | 20-14 | |
| » Starters: Mike Garcia vs Frank Lary | Third | 3 out |
| Tuesday, May 28 |
| » Defeated Tigers (18-19), 4-3 | Tiger Stadium (2-3) | 21-14 | |
| » Starters: Don Mossi vs Billy Hoeft | Third | 3 out |
| Wednesday, May 29 |
| » Defeated White Sox (23-11), 8-4 | Comiskey Park I (2-0) | 22-14 | Won 2 |
| » Starters: Early Wynn vs Jack Harshman | Second | 2 out |
| Thursday, May 30 |
| » Lost to White Sox (24-11), 6-4 | Comiskey Park I (2-1) | 22-15 | |
| » Starters: Bud Daley vs Dick Donovan | Third | 4 out |
| » Lost to White Sox (25-11), 2-1 | Comiskey Park I (2-2) | 22-16 | Lost 2 |
| » Starters: Mike Garcia vs Billy Pierce | Third | 4 out |
| Friday, May 31 |
| » Lost to Athletics (18-23), 3-1 | Municipal Stadium (1-2) | 22-17 | Lost 3 |
| » Starters: Cal McLish vs Ned Garver | Third | 5 out |
| Saturday, June 1 |
| » Defeated Athletics (18-24), 3-0 | Municipal Stadium (2-2) | 23-17 | |
| » Starters: Early Wynn vs Wally Burnette | Second | 5 out |
| Sunday, June 2 |
| » Lost to Athletics (19-24), 8-2 | Municipal Stadium (2-3) | 23-18 | |
| » Starters: Mike Garcia vs Alex Kellner | Third | 5½ out |
| Tuesday, June 4 |
| » Lost to Yankees (25-18), 7-4 | Cleveland Stadium (12-9) | 23-19 | Lost 2 |
| » Starters: Tom Sturdivant vs Bud Daley | Third | 6½ out |
| Future Indian Tony Pena is born in Monte Cristi, D.R. |
| Wednesday, June 5 |
| » Lost to Yankees (26-18), 13-3 | Cleveland Stadium (12-10) | 23-20 | Lost 3 |
| » Starters: Bobby Shantz vs Early Wynn | Third | 7½ out |
| Thursday, June 6 |
| » Lost to Yankees (27-18), 14-5 | Cleveland Stadium (12-11) | 23-21 | Lost 4 |
| » Starters: Johnny Kucks vs Mike Garcia | Third | 8½ out |
| Friday, June 7 |
| » Lost to Senators (17-33), 11-7 | Cleveland Stadium (12-12) | 23-22 | Lost 5 |
| » Starters: Chuck Stobbs vs Bud Daley | Fourth | 8½ out |
| Saturday, June 8 |
| » Defeated Senators (17-34), 6-4 | Cleveland Stadium (13-12) | 24-22 | |
| » Starters: Camilo Pascual vs Don Mossi | Fourth | 8½ out |
| Sunday, June 9 |
| » Defeated Senators (17-35), 7-2 | Cleveland Stadium (14-12) | 25-22 | Won 2 |
| » Starters: Russ Kemmerer vs Early Wynn | Third | 7½ out |
| » Lost to Senators (18-35), 7-6 | Cleveland Stadium (14-13) | 25-23 | |
| » Starters: Pedro Ramos vs Mike Garcia | Third | 7½ out |
| Tuesday, June 11 |
| » Defeated Red Sox (26-26), 7-6 | Cleveland Stadium (15-13) | 26-23 | |
| » Starters: Dean Stone vs Dick Tomanek | Third | 6½ out |
| Wednesday, June 12 |
| » Defeated Red Sox (26-27), 6-1 | Cleveland Stadium (16-13) | 27-23 | Won 2 |
| » Starters: Bob Porterfield vs Don Mossi | Third | 6½ out |
| Thursday, June 13 |
| » Lost to Red Sox (27-27), 9-3 | Cleveland Stadium (16-14) | 27-24 | |
| » Starters: Tom Brewer vs Early Wynn | Fourth | 6½ out |
| Friday, June 14 |
| » Defeated Orioles (23-30), 7-2 | Cleveland Stadium (17-14) | 28-24 | |
| » Starters: Bill Wight vs Mike Garcia | Fourth | 6½ out |
| Saturday, June 15 |
| » Lost to Orioles (24-30), 8-3 | Cleveland Stadium (17-15) | 28-25 | |
| » Starters: Billy Loes vs Bud Daley | Fourth | 6½ out |
| Future Indian Brett Butler is born in Los Angeles, CA. |
| Sunday, June 16 |
| » Defeated Orioles (24-31), 4-3 | Cleveland Stadium (18-15) | 29-25 | |
| » Starters: Connie Johnson vs Don Mossi | Fourth | 6½ out |
| » Defeated Orioles (24-32), 5-1 | Cleveland Stadium (19-15) | 30-25 | Won 2 |
| » Starters: Billy O'Dell vs Early Wynn | Fourth | 6½ out |
| Tuesday, June 18 |
| » Defeated Red Sox (27-31), 7-6 | Fenway Park (2-1) | 31-25 | Won 3 |
| » Starters: Bob Lemon vs Tom Brewer | Third | 5½ out |
| Former Indian Milo Allison dies in Kenosha, WI at the age of 67. |
| Wednesday, June 19 |
| » Lost to Red Sox (28-31), 6-0 | Fenway Park (2-2) | 31-26 | |
| » Starters: Mike Garcia vs Frank Sullivan | Third | 6½ out |
| Thursday, June 20 |
| » Lost to Red Sox (29-31), 9-7 | Fenway Park (2-3) | 31-27 | Lost 2 |
| » Starters: Early Wynn vs Dave Sisler | Third | 6½ out |
| » Major-league debuts: Dick Brown (Indians) |
| Friday, June 21 |
| » Lost to Senators (22-42), 6-3 | Griffith Stadium (2-1) | 31-28 | Lost 3 |
| » Starters: Don Mossi vs Chuck Stobbs | Fourth | 6½ out |
| Saturday, June 22 |
| » Defeated Senators (22-43), 7-1 | Griffith Stadium (3-1) | 32-28 | |
| » Starters: Bob Lemon vs Camilo Pascual | Third | 6 out |
| Sunday, June 23 |
| » Defeated Senators (22-44), 14-2 | Griffith Stadium (4-1) | 33-28 | Won 2 |
| » Starters: Early Wynn vs Ted Abernathy | Third | 5 out |
| » Defeated Senators (22-45), 7-5 | Griffith Stadium (5-1) | 34-28 | Won 3 |
| » Starters: Mike Garcia vs Russ Kemmerer | Third | 5 out |
| Monday, June 24 |
| Future Indian Doug Jones is born in Lebanon, IN. |
| Tuesday, June 25 |
| » Defeated Yankees (39-24), 11-2 | Yankee Stadium (1-1) | 35-28 | Won 4 |
| » Starters: Don Mossi vs Tom Sturdivant | Third | 4½ out |
| Wednesday, June 26 |
| » Lost to Yankees (40-24), 3-1 | Yankee Stadium (1-2) | 35-29 | |
| » Starters: Bob Lemon vs Johnny Kucks | Third | 5½ out |
| Thursday, June 27 |
| » Defeated Yankees (40-25), 2-0 | Yankee Stadium (2-2) | 36-29 | |
| » Starters: Early Wynn vs Tommy Byrne | Second | 4 out |
| Friday, June 28 |
| » Lost to Orioles (32-34), 6-0 | Memorial Stadium (2-1) | 36-30 | |
| » Starters: Mike Garcia vs Ray Moore | Second | 5 out |
| Saturday, June 29 |
| » Defeated Orioles (32-35), 2-1 | Memorial Stadium (3-1) | 37-30 | |
| » Starters: Stan Pitula vs Billy O'Dell | Second | 5½ out |
| » Lost to Orioles (33-35), 5-1 | Memorial Stadium (3-2) | 37-31 | |
| » Starters: Don Mossi vs Bill Wight | Second | 5½ out |
| Sunday, June 30 |
| » Lost to Orioles (34-35), 12-3 | Memorial Stadium (3-3) | 37-32 | Lost 2 |
| » Starters: Bob Lemon vs Billy Loes | Third | 7 out |
| Future Indian Bud Black is born in San Mateo, CA. |
| Monday, July 1 |
| » Lost to Athletics (26-44), 10-3 | Cleveland Stadium (19-16) | 37-33 | Lost 3 |
| » Starters: Arnie Portocarrero vs Early Wynn | Third | 8 out |
| Wednesday, July 3 |
| » Defeated Tigers (36-37), 6-0 | Cleveland Stadium (20-16) | 38-33 | |
| » Starters: Duke Maas vs Don Mossi | Third | 8½ out |
| Thursday, July 4 |
| » Defeated Tigers (36-38), 3-1 | Cleveland Stadium (21-16) | 39-33 | Won 2 |
| » Starters: Paul Foytack vs Early Wynn | Third | 8½ out |
| » Lost to Tigers (37-38), 4-3 | Cleveland Stadium (21-17) | 39-34 | |
| » Starters: Billy Hoeft vs Ray Narleski | Third | 8½ out |
| Friday, July 5 |
| » Lost to White Sox (46-29), 14-4 | Comiskey Park I (2-3) | 39-35 | Lost 2 |
| » Starters: Stan Pitula vs Jim Wilson | Fourth | 9½ out |
| Saturday, July 6 |
| » Lost to White Sox (47-29), 5-1 | Comiskey Park I (2-4) | 39-36 | Lost 3 |
| » Starters: Bob Lemon vs Billy Pierce | Fourth | 10½ out |
| Sunday, July 7 |
| » Lost to White Sox (48-29), 9-8 | Comiskey Park I (2-5) | 39-37 | Lost 4 |
| » Starters: Don Mossi vs Dick Donovan | Fourth | 12 out |
| » Lost to White Sox (49-29), 7-2 | Comiskey Park I (2-6) | 39-38 | Lost 5 |
| » Starters: Early Wynn vs Jack Harshman | Fourth | 12 out |
| Thursday, July 11 |
| » Lost to Orioles (38-39), 5-4 | Cleveland Stadium (21-18) | 39-39 | Lost 6 |
| » Starters: Ray Moore vs Ray Narleski | Fifth | 13½ out |
| » Lost to Orioles (39-39), 5-4 | Cleveland Stadium (21-19) | 39-40 | Lost 7 |
| » Starters: Bill Wight vs Bob Lemon | Fifth | 13½ out |
| Friday, July 12 |
| » Defeated Orioles (39-40), 8-6 | Cleveland Stadium (22-19) | 40-40 | |
| » Starters: Connie Johnson vs Early Wynn | Fourth | 13½ out |
| Saturday, July 13 |
| » Defeated Orioles (39-41), 5-2 | Cleveland Stadium (23-19) | 41-40 | Won 2 |
| » Starters: Billy O'Dell vs Don Mossi | Fourth | 12½ out |
| Sunday, July 14 |
| » Defeated Red Sox (44-39), 3-2 | Cleveland Stadium (24-19) | 42-40 | Won 3 |
| » Starters: Willard Nixon vs Bob Lemon | Fourth | 11½ out |
| » Defeated Red Sox (44-40), 17-4 | Cleveland Stadium (25-19) | 43-40 | Won 4 |
| » Starters: Dave Sisler vs Stan Pitula | Fourth | 11½ out |
| Tuesday, July 16 |
| » Defeated Senators (28-59), 9-3 | Cleveland Stadium (26-19) | 44-40 | Won 5 |
| » Starters: Ted Abernathy vs Early Wynn | Fourth | 11½ out |
| Wednesday, July 17 |
| » Lost to Senators (29-59), 11-6 | Cleveland Stadium (26-20) | 44-41 | |
| » Starters: Chuck Stobbs vs Don Mossi | Fourth | 12½ out |
| Thursday, July 18 |
| » Lost to Senators (30-59), 4-0 | Cleveland Stadium (26-21) | 44-42 | Lost 2 |
| » Starters: Camilo Pascual vs Stan Pitula | Fourth | 13½ out |
| Friday, July 19 |
| » Lost to Yankees (58-28), 9-1 | Cleveland Stadium (26-22) | 44-43 | Lost 3 |
| » Starters: Whitey Ford vs Don Mossi | Fourth | 14½ out |
| Saturday, July 20 |
| » Defeated Yankees (58-29), 4-2 | Cleveland Stadium (27-22) | 45-43 | |
| » Starters: Bobby Shantz vs Early Wynn | Fourth | 13½ out |
| Sunday, July 21 |
| » Lost to Yankees (59-29), 4-3 | Cleveland Stadium (27-23) | 45-44 | |
| » Starters: Tom Sturdivant vs Bob Lemon | Fourth | 13½ out |
| » Defeated Yankees (59-30), 7-4 | Cleveland Stadium (28-23) | 46-44 | |
| » Starters: Johnny Kucks vs Ray Narleski | Fourth | 13½ out |
| Wednesday, July 24 |
| » Defeated Senators (31-62), 4-3 | Griffith Stadium (6-1) | 47-44 | Won 2 |
| » Starters: Stan Pitula vs Camilo Pascual | Fourth | 13½ out |
| » Lost to Senators (32-62), 5-4 | Griffith Stadium (6-2) | 47-45 | |
| » Starters: Early Wynn vs Chuck Stobbs | Fourth | 13½ out |
| Thursday, July 25 |
| » Lost to Senators (33-62), 3-2 | Griffith Stadium (6-3) | 47-46 | Lost 2 |
| » Starters: Mike Garcia vs Russ Kemmerer | Fourth | 13½ out |
| Friday, July 26 |
| » Lost to Red Sox (51-43), 10-1 | Fenway Park (2-4) | 47-47 | Lost 3 |
| » Starters: Don Mossi vs Willard Nixon | Fifth | 13½ out |
| Saturday, July 27 |
| » Defeated Red Sox (51-44), 7-2 | Fenway Park (3-4) | 48-47 | |
| » Starters: Ray Narleski vs Ike Delock | Fourth | 13½ out |
| Sunday, July 28 |
| » Lost to Red Sox (52-44), 9-8 | Fenway Park (3-5) | 48-48 | |
| » Starters: Early Wynn vs Frank Sullivan | Fourth | 14 out |
| Monday, July 29 |
| » Lost to Red Sox (53-44), 6-2 | Fenway Park (3-6) | 48-49 | Lost 2 |
| » Starters: Mike Garcia vs Tom Brewer | Fifth | 14½ out |
| Tuesday, July 30 |
| » Defeated Orioles (46-52), 6-0 | Memorial Stadium (4-3) | 49-49 | |
| » Starters: Johnny Gray vs Billy Loes | Fourth | 14½ out |
| Wednesday, July 31 |
| » Defeated Orioles (46-53), 4-0 | Memorial Stadium (5-3) | 50-49 | Won 2 |
| » Starters: Ray Narleski vs Ray Moore | Fourth | 15 out |
| Friday, August 2 |
| » Lost to Yankees (66-34), 3-2 | Yankee Stadium (2-3) | 50-50 | |
| » Starters: Don Mossi vs Tom Sturdivant | Fourth | 16 out |
| Saturday, August 3 |
| » Lost to Yankees (67-34), 5-3 | Yankee Stadium (2-4) | 50-51 | Lost 2 |
| » Starters: Early Wynn vs Art Ditmar | Fourth | 17 out |
| Sunday, August 4 |
| » Lost to Yankees (68-34), 5-2 | Yankee Stadium (2-5) | 50-52 | Lost 3 |
| » Starters: Johnny Gray vs Whitey Ford | Fifth | 19 out |
| » Lost to Yankees (69-34), 6-5 | Yankee Stadium (2-6) | 50-53 | Lost 4 |
| » Starters: Ray Narleski vs Tommy Byrne | Fifth | 19 out |
| Monday, August 5 |
| » Defeated Yankees (69-35), 7-2 | Yankee Stadium (3-6) | 51-53 | |
| » Starters: Mike Garcia vs Don Larsen | Fifth | 18 out |
| Tuesday, August 6 |
| » Defeated Tigers (50-53), 5-1 | Tiger Stadium (3-3) | 52-53 | Won 2 |
| » Starters: Don Mossi vs Jim Bunning | Fourth | 18 out |
| Wednesday, August 7 |
| » Lost to Tigers (51-53), 4-1 | Tiger Stadium (3-4) | 52-54 | |
| » Starters: Johnny Gray vs Billy Hoeft | Fourth | 18 out |
| Thursday, August 8 |
| » Defeated Tigers (51-54), 3-1 | Tiger Stadium (4-4) | 53-54 | |
| » Starters: Ray Narleski vs Duke Maas | Fourth | 17 out |
| Friday, August 9 |
| » Lost to Athletics (38-69), 3-2 | Cleveland Stadium (28-24) | 53-55 | |
| » Starters: Ralph Terry vs Early Wynn | Fifth | 17 out |
| Saturday, August 10 |
| » Lost to Athletics (39-69), 8-5 | Cleveland Stadium (28-25) | 53-56 | Lost 2 |
| » Starters: Jack Urban vs Mike Garcia | Sixth | 18 out |
| Sunday, August 11 |
| » Lost to Athletics (40-69), 7-0 | Cleveland Stadium (28-26) | 53-57 | Lost 3 |
| » Starters: Ned Garver vs Bud Daley | Fifth | 19½ out |
| » Lost to Athletics (41-69), 9-8 | Cleveland Stadium (28-27) | 53-58 | Lost 4 |
| » Starters: Alex Kellner vs Don Mossi | Fifth | 19½ out |
| Tuesday, August 13 |
| » Lost to White Sox (67-43), 10-5 | Cleveland Stadium (28-28) | 53-59 | Lost 5 |
| » Starters: Billy Pierce vs Ray Narleski | Sixth | 20½ out |
| Wednesday, August 14 |
| » Lost to White Sox (68-43), 8-3 | Cleveland Stadium (28-29) | 53-60 | Lost 6 |
| » Starters: Dick Donovan vs Early Wynn | Sixth | 20½ out |
| Former Indian Tim Hendryx dies in Corpus Christi, TX at the age of 67. |
| Thursday, August 15 |
| » Defeated White Sox (68-44), 5-4 | Cleveland Stadium (29-29) | 54-60 | |
| » Starters: Jack Harshman vs Don Mossi | Sixth | 20½ out |
| Friday, August 16 |
| » Defeated Athletics (43-72), 4-2 | Municipal Stadium (3-3) | 55-60 | Won 2 |
| » Starters: Mike Garcia vs Alex Kellner | Sixth | 19½ out |
| Saturday, August 17 |
| » Lost to Athletics (44-72), 4-3 | Municipal Stadium (3-4) | 55-61 | |
| » Starters: Early Wynn vs Ned Garver | Sixth | 20½ out |
| Sunday, August 18 |
| » Defeated Athletics (44-73), 9-2 | Municipal Stadium (4-4) | 56-61 | |
| » Starters: Cal McLish vs Arnie Portocarrero | Sixth | 21 out |
| Monday, August 19 |
| » Lost to Athletics (45-73), 1-0 | Municipal Stadium (4-5) | 56-62 | |
| » Starters: Ray Narleski vs Tom Gorman | Sixth | 21½ out |
| Tuesday, August 20 |
| » Defeated Red Sox (61-56), 5-4 | Cleveland Stadium (30-29) | 57-62 | |
| » Starters: Tom Brewer vs Don Mossi | Sixth | 20½ out |
| Wednesday, August 21 |
| » Lost to Red Sox (62-56), 3-1 | Cleveland Stadium (30-30) | 57-63 | |
| » Starters: Willard Nixon vs Mike Garcia | Sixth | 20½ out |
| Thursday, August 22 |
| » Lost to Red Sox (63-56), 11-3 | Cleveland Stadium (30-31) | 57-64 | Lost 2 |
| » Starters: Mike Fornieles vs Early Wynn | Sixth | 21½ out |
| Friday, August 23 |
| » Defeated Yankees (78-43), 5-4 | Cleveland Stadium (31-31) | 58-64 | |
| » Starters: Bobby Shantz vs Ray Narleski | Sixth | 20½ out |
| Saturday, August 24 |
| » Lost to Yankees (79-43), 10-4 | Cleveland Stadium (31-32) | 58-65 | |
| » Starters: Tom Sturdivant vs Don Mossi | Sixth | 21½ out |
| Sunday, August 25 |
| » Defeated Senators (47-76), 3-2 | Cleveland Stadium (32-32) | 59-65 | |
| » Starters: Chuck Stobbs vs Mike Garcia | Sixth | 20 out |
| » Defeated Senators (47-77), 6-4 | Cleveland Stadium (33-32) | 60-65 | Won 2 |
| » Starters: Russ Kemmerer vs Cal McLish | Sixth | 20 out |
| Tuesday, August 27 |
| » Defeated Orioles (59-64), 5-4 | Cleveland Stadium (34-32) | 61-65 | Won 3 |
| » Starters: Ray Moore vs Early Wynn | Fifth | 19½ out |
| Wednesday, August 28 |
| » Lost to Orioles (60-64), 19-6 | Cleveland Stadium (34-33) | 61-66 | |
| » Starters: Connie Johnson vs Ray Narleski | Sixth | 20½ out |
| Thursday, August 29 |
| » Defeated Orioles (60-65), 13-4 | Cleveland Stadium (35-33) | 62-66 | |
| » Starters: Billy O'Dell vs Mike Garcia | Fifth | 20½ out |
| Friday, August 30 |
| » Defeated Tigers (63-65), 6-5 | Cleveland Stadium (36-33) | 63-66 | Won 2 |
| » Starters: Billy Hoeft vs Cal McLish | Fifth | 19½ out |
| Saturday, August 31 |
| » Lost to Tigers (64-65), 8-7 | Cleveland Stadium (36-34) | 63-67 | |
| » Starters: Frank Lary vs Early Wynn | Fifth | 19½ out |
| Future Indian Tom Candiotti is born in Walnut Creek, CA. |
| Sunday, September 1 |
| » Lost to Tigers (65-65), 6-1 | Cleveland Stadium (36-35) | 63-68 | Lost 2 |
| » Starters: Jim Bunning vs Ray Narleski | Sixth | 20½ out |
| Monday, September 2 |
| » Defeated Athletics (50-81), 8-0 | Cleveland Stadium (37-35) | 64-68 | |
| » Starters: Ned Garver vs Mike Garcia | Sixth | 18½ out |
| » Defeated Athletics (50-82), 6-3 | Cleveland Stadium (38-35) | 65-68 | Won 2 |
| » Starters: Ralph Terry vs Vito Valentinetti | Sixth | 18½ out |
| Friday, September 6 |
| » Lost to Tigers (68-66), 5-2 | Tiger Stadium (4-5) | 65-69 | |
| » Starters: Early Wynn vs Jim Bunning | Fifth | 19 out |
| Saturday, September 7 |
| » Defeated Tigers (68-67), 5-4 | Tiger Stadium (5-5) | 66-69 | |
| » Starters: Mike Garcia vs Frank Lary | Fifth | 19 out |
| Sunday, September 8 |
| » Lost to Tigers (69-67), 3-1 | Tiger Stadium (5-6) | 66-70 | |
| » Starters: Cal McLish vs Billy Hoeft | Fifth | 20 out |
| Tuesday, September 10 |
| » Major-league debuts: Barry Latman (White Sox) |
| Wednesday, September 11 |
| » Lost to Yankees (88-51), 5-0 | Yankee Stadium (3-7) | 66-71 | Lost 2 |
| » Starters: Early Wynn vs Sal Maglie | Fifth | 20 out |
| » Defeated Yankees (88-52), 4-1 | Yankee Stadium (4-7) | 67-71 | |
| » Starters: Ray Narleski vs Bobby Shantz | Fifth | 20 out |
| Friday, September 13 |
| » Defeated Red Sox (75-65), 16-3 | Fenway Park (4-6) | 68-71 | Won 2 |
| » Starters: Mike Garcia vs Dave Sisler | Fifth | 20 out |
| Saturday, September 14 |
| » Lost to Red Sox (76-65), 13-10 | Fenway Park (4-7) | 68-72 | |
| » Starters: Cal McLish vs Mike Fornieles | Fifth | 20 out |
| Sunday, September 15 |
| » Lost to Orioles (68-73), 5-4 | Memorial Stadium (5-4) | 68-73 | Lost 2 |
| » Starters: Early Wynn vs Bill Wight | Sixth | 22 out |
| » Lost to Orioles (69-73), 4-3 | Memorial Stadium (5-5) | 68-74 | Lost 3 |
| » Starters: Don Mossi vs Ray Moore | Sixth | 22 out |
| Tuesday, September 17 |
| » Defeated Senators (54-89), 7-3 | Griffith Stadium (7-3) | 69-74 | |
| » Starters: Ray Narleski vs Camilo Pascual | Sixth | 22 out |
| Wednesday, September 18 |
| » Defeated Senators (54-90), 8-3 | Griffith Stadium (8-3) | 70-74 | Won 2 |
| » Starters: Mike Garcia vs Russ Kemmerer | Fifth | 22 out |
| Friday, September 20 |
| » Defeated White Sox (86-59), 3-2 | Cleveland Stadium (39-35) | 71-74 | Won 3 |
| » Starters: Dick Donovan vs Don Mossi | Fifth | 22 out |
| Saturday, September 21 |
| » Lost to White Sox (87-59), 7-6 | Cleveland Stadium (39-36) | 71-75 | |
| » Starters: Barry Latman vs Early Wynn | Fifth | 22 out |
| » Major-league debuts: Don Rudolph (White Sox) |
| Sunday, September 22 |
| » Lost to White Sox (88-59), 9-5 | Cleveland Stadium (39-37) | 71-76 | Lost 2 |
| » Starters: Billy Pierce vs Mike Garcia | Sixth | 23 out |
| Monday, September 23 |
| » Defeated Tigers (75-74), 5-4 | Cleveland Stadium (40-37) | 72-76 | |
| » Starters: Jim Bunning vs Cal McLish | Sixth | 22½ out |
| Wednesday, September 25 |
| » Defeated Athletics (57-92), 9-7 | Municipal Stadium (5-5) | 73-76 | Won 2 |
| » Starters: Ray Narleski vs Tom Gorman | Fifth | 22 out |
| Thursday, September 26 |
| » Defeated Athletics (57-93), 2-1 | Municipal Stadium (6-5) | 74-76 | Won 3 |
| » Starters: Vito Valentinetti vs Ralph Terry | Fifth | 21½ out |
| Friday, September 27 |
| » Lost to White Sox (90-62), 2-1 | Comiskey Park I (2-7) | 74-77 | |
| » Starters: Don Mossi vs Jack Harshman | Sixth | 22½ out |
| Saturday, September 28 |
| » Defeated White Sox (90-63), 4-1 | Comiskey Park I (3-7) | 75-77 | |
| » Starters: Hank Aguirre vs Billy Pierce | Sixth | 22½ out |
| Sunday, September 29 |
| » Defeated White Sox (90-64), 5-3 | Comiskey Park I (4-7) | 76-77 | Won 2 |
| » Starters: Bud Daley vs Barry Latman | Sixth | 21½ out |
| Sunday, October 6 |
| Future Indian Alfredo Griffin is born in Santo Domingo, D.R. |
| Tuesday, October 15 |
| Former Indian Neal Ball dies in Bridgeport, CT at the age of 77. |
| Wednesday, October 30 |
| Future Indian Houston Jimenez is born in Navojoa, Mexico. Former Indian Fred Beebe dies in Elgin, IL at the age of 77. |
| Friday, November 8 |
| Former Indian Joe Connor dies in Waterbury, CT at the age of 83. |
| Tuesday, December 17 |
| Future Indian Bob Ojeda is born in Los Angeles, CA. |
| Friday, December 20 |
| Future Indian Bill Laskey is born in Toledo, OH. |
| Tuesday, December 24 |
| Future Indian Victor Cruz is born in Rancho Viejo, D.R. |
Game information provided by Retrosheet (www.retrosheet.org) |
