| Sunday, March 3 |
| Future Cardinal Skeeter Barnes is born in Cincinnati, OH. |
| Wednesday, March 13 |
| Future Cardinal Duane Walker is born in Pasadena, TX. |
| Thursday, March 14 |
| Future Cardinal Steve Lake is born in Inglewood, CA. |
| Monday, April 15 |
| » Major-league debuts: Neil Chrisley (Senators) |
| Tuesday, April 16 |
| » Defeated Reds (0-1), 13-4 | Crosley Field (1-0) | 1-0 | |
| » Starters: Herm Wehmeier vs Johnny Klippstein | First | -- |
| » Major-league debuts: Bobby Gene Smith (Cardinals) |
| Thursday, April 18 |
| » Lost to Cubs (1-1), 10-2 | Sportsman's Park III (0-1) | 1-1 | |
| » Starters: Moe Drabowsky vs Murry Dickson | Second | 1 out |
| » Major-league debuts: Eddie Kasko (Cardinals) |
| Saturday, April 20 |
| » Major-league debuts: Don Pavletich (Reds) |
| Sunday, April 21 |
| » Lost to Cubs (2-1), 5-3 | Sportsman's Park III (0-2) | 1-2 | Lost 2 |
| » Starters: Don Kaiser vs Herm Wehmeier | Third | 2 out |
| » Defeated Cubs (2-2), 6-3 | Sportsman's Park III (1-2) | 2-2 | |
| » Starters: Dick Drott vs Sam Jones | Third | 2 out |
| » Major-league debuts: Tom Cheney (Cardinals) |
| Future Cardinal Jesse Orosco is born in Santa Barbara, CA. |
| Monday, April 22 |
| » Lost to Reds (1-4), 10-6 | Sportsman's Park III (1-3) | 2-3 | |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Fourth | 3 out |
| Tuesday, April 23 |
| » Lost to Reds (2-4), 6-4 | Sportsman's Park III (1-4) | 2-4 | Lost 2 |
| » Starters: Hal Jeffcoat vs Murry Dickson | Fourth | 3 out |
| Wednesday, April 24 |
| » Lost to Braves (6-1), 8-7 | County Stadium (0-1) | 2-5 | Lost 3 |
| » Starters: Herm Wehmeier vs Ray Crone | Fourth | 4 out |
| Sunday, April 28 |
| » Defeated Cubs (3-6), 6-2 | Wrigley Field (1-0) | 3-5 | |
| » Starters: Lindy McDaniel vs Bob Rush | Fifth | 4½ out |
| » Defeated Cubs (3-7), 4-0 | Wrigley Field (2-0) | 4-5 | Won 2 |
| » Starters: Tom Cheney vs Tom Poholsky | Fifth | 4½ out |
| Tuesday, April 30 |
| » Defeated Pirates (4-8), 6-5 | Forbes Field (1-0) | 5-5 | Won 3 |
| » Starters: Sam Jones vs Luis Arroyo | Fourth | 3½ out |
| Wednesday, May 1 |
| » Defeated Pirates (4-9), 9-2 | Forbes Field (2-0) | 6-5 | Won 4 |
| » Starters: Willard Schmidt vs Bob Purkey | Third | 3½ out |
| Thursday, May 2 |
| » Defeated Dodgers (9-4), 3-2 | Ebbets Field (1-0) | 7-5 | Won 5 |
| » Starters: Herm Wehmeier vs Johnny Podres | Third | 3½ out |
| Friday, May 3 |
| » Lost to Dodgers (10-4), 6-0 | Roosevelt Stadium (0-1) | 7-6 | |
| » Starters: Tom Cheney vs Don Newcombe | Third | 4½ out |
| Saturday, May 4 |
| » Lost to Dodgers (11-4), 4-2 | Ebbets Field (1-1) | 7-7 | Lost 2 |
| » Starters: Lindy McDaniel vs Roger Craig | Fourth | 4½ out |
| Sunday, May 5 |
| » Defeated Phillies (8-9), 8-4 | Shibe Park (1-0) | 8-7 | |
| » Starters: Willard Schmidt vs Curt Simmons | Fourth | 4 out |
| » Defeated Phillies (8-10), 2-0 | Shibe Park (2-0) | 9-7 | Won 2 |
| » Starters: Sam Jones vs Harvey Haddix | Fourth | 4 out |
| Tuesday, May 7 |
| » Lost to Giants (9-12), 8-5 | Polo Grounds V (0-1) | 9-8 | |
| » Starters: Herm Wehmeier vs Pete Burnside | Fourth | 3½ out |
| Wednesday, May 8 |
| » Defeated Giants (9-13), 13-4 | Polo Grounds V (1-1) | 10-8 | |
| » Starters: Tom Cheney vs Johnny Antonelli | Fourth | 2½ out |
| Thursday, May 9 |
| Future Cardinal John Stuper is born in Butler, PA. |
| Friday, May 10 |
| » Lost to Braves (14-6), 10-5 | Sportsman's Park III (1-5) | 10-9 | |
| » Starters: Juan Pizarro vs Sam Jones | Fourth | 3½ out |
| Saturday, May 11 |
| » Defeated Braves (14-7), 8-7 | Sportsman's Park III (2-5) | 11-9 | |
| » Starters: Warren Spahn vs Lindy McDaniel | Third | 2½ out |
| Sunday, May 12 |
| » Lost to Braves (15-7), 4-2 | Sportsman's Park III (2-6) | 11-10 | |
| » Starters: Lew Burdette vs Murry Dickson | Fourth | 4½ out |
| » Lost to Braves (16-7), 10-4 | Sportsman's Park III (2-7) | 11-11 | Lost 2 |
| » Starters: Red Murff vs Herm Wehmeier | Fourth | 4½ out |
| Tuesday, May 14 |
| » Lost to Giants (12-14), 5-3 | Sportsman's Park III (2-8) | 11-12 | Lost 3 |
| » Starters: Ruben Gomez vs Vinegar Bend Mizell | Fifth | 5½ out |
| Wednesday, May 15 |
| » Defeated Giants (12-15), 6-5 | Sportsman's Park III (3-8) | 12-12 | |
| » Starters: Johnny Antonelli vs Sam Jones | Fourth | 4½ out |
| Thursday, May 16 |
| » Defeated Phillies (14-13), 5-0 | Sportsman's Park III (4-8) | 13-12 | Won 2 |
| » Starters: Harvey Haddix vs Lindy McDaniel | Fourth | 4½ out |
| Friday, May 17 |
| » Lost to Phillies (15-13), 5-3 | Sportsman's Park III (4-9) | 13-13 | |
| » Starters: Robin Roberts vs Sam Jones | Fifth | 5½ out |
| Saturday, May 18 |
| » Lost to Phillies (16-13), 7-5 | Sportsman's Park III (4-10) | 13-14 | Lost 2 |
| » Starters: Curt Simmons vs Vinegar Bend Mizell | Fifth | 5½ out |
| Sunday, May 19 |
| » Lost to Dodgers (16-10), 10-3 | Sportsman's Park III (4-11) | 13-15 | Lost 3 |
| » Starters: Don Newcombe vs Larry Jackson | Fifth | 7 out |
| Monday, May 20 |
| » Lost to Dodgers (17-10), 10-4 | Sportsman's Park III (4-12) | 13-16 | Lost 4 |
| » Starters: Don Drysdale vs Herm Wehmeier | Sixth | 7½ out |
| Thursday, May 23 |
| » Lost to Reds (23-10), 6-2 | Crosley Field (1-1) | 13-17 | Lost 5 |
| » Starters: Lindy McDaniel vs Don Gross | Sixth | 8½ out |
| Friday, May 24 |
| » Defeated Reds (23-11), 9-6 | Crosley Field (2-1) | 14-17 | |
| » Starters: Sam Jones vs Joe Nuxhall | Fourth | 7½ out |
| Saturday, May 25 |
| » Defeated Reds (23-12), 12-4 | Crosley Field (3-1) | 15-17 | Won 2 |
| » Starters: Willard Schmidt vs Brooks Lawrence | Fifth | 6½ out |
| Sunday, May 26 |
| » Lost to Reds (24-12), 7-6 | Crosley Field (3-2) | 15-18 | |
| » Starters: Murry Dickson vs Hal Jeffcoat | Fifth | 7½ out |
| Monday, May 27 |
| » Defeated Cubs (11-21), 6-2 | Sportsman's Park III (5-12) | 16-18 | |
| » Starters: Bob Rush vs Lindy McDaniel | Fifth | 7½ out |
| Tuesday, May 28 |
| » Defeated Cubs (11-22), 5-1 | Sportsman's Park III (6-12) | 17-18 | Won 2 |
| » Starters: Moe Drabowsky vs Larry Jackson | Fifth | 6½ out |
| Thursday, May 30 |
| » Defeated Reds (25-14), 7-2 | Sportsman's Park III (7-12) | 18-18 | Won 3 |
| » Starters: Joe Nuxhall vs Willard Schmidt | Fifth | 6½ out |
| » Lost to Reds (26-14), 7-3 | Sportsman's Park III (7-13) | 18-19 | |
| » Starters: Brooks Lawrence vs Vinegar Bend Mizell | Fifth | 6½ out |
| Friday, May 31 |
| » Defeated Braves (23-16), 4-3 | County Stadium (1-1) | 19-19 | |
| » Starters: Lindy McDaniel vs Juan Pizarro | Fifth | 6 out |
| Saturday, June 1 |
| » Defeated Braves (23-17), 7-1 | County Stadium (2-1) | 20-19 | Won 2 |
| » Starters: Murry Dickson vs Warren Spahn | Fifth | 6 out |
| Sunday, June 2 |
| » Lost to Braves (24-17), 3-1 | County Stadium (2-2) | 20-20 | |
| » Starters: Larry Jackson vs Bob Buhl | Fifth | 6½ out |
| Tuesday, June 4 |
| » Lost to Pirates (15-28), 5-4 | Forbes Field (2-1) | 20-21 | Lost 2 |
| » Starters: Willard Schmidt vs Bob Smith | Fifth | 6½ out |
| Future Cardinal Tony Pena is born in Monte Cristi, D.R. |
| Wednesday, June 5 |
| » Defeated Pirates (15-29), 5-1 | Forbes Field (3-1) | 21-21 | |
| » Starters: Lindy McDaniel vs Bob Friend | Fifth | 6½ out |
| Thursday, June 6 |
| » Defeated Pirates (15-30), 6-0 | Forbes Field (4-1) | 22-21 | Won 2 |
| » Starters: Murry Dickson vs Ron Kline | Fifth | 5½ out |
| Friday, June 7 |
| » Defeated Giants (21-28), 5-3 | Polo Grounds V (2-1) | 23-21 | Won 3 |
| » Starters: Larry Jackson vs Curt Barclay | Fifth | 4½ out |
| Saturday, June 8 |
| » Defeated Giants (21-29), 5-4 | Polo Grounds V (3-1) | 24-21 | Won 4 |
| » Starters: Willard Schmidt vs Al Worthington | Fifth | 4 out |
| Sunday, June 9 |
| » Defeated Giants (21-30), 2-1 | Polo Grounds V (4-1) | 25-21 | Won 5 |
| » Starters: Vinegar Bend Mizell vs Stu Miller | Fifth | 3½ out |
| » Defeated Giants (21-31), 10-7 | Polo Grounds V (5-1) | 26-21 | Won 6 |
| » Starters: Lindy McDaniel vs Pete Burnside | Fifth | 3½ out |
| Tuesday, June 11 |
| » Defeated Phillies (28-21), 5-2 | Shibe Park (3-0) | 27-21 | Won 7 |
| » Starters: Murry Dickson vs Curt Simmons | Fourth | 2 out |
| Wednesday, June 12 |
| » Defeated Phillies (28-22), 4-0 | Shibe Park (4-0) | 28-21 | Won 8 |
| » Starters: Larry Jackson vs Robin Roberts | Third | 2 out |
| Thursday, June 13 |
| » Lost to Phillies (29-22), 8-1 | Shibe Park (4-1) | 28-22 | |
| » Starters: Vinegar Bend Mizell vs Jack Sanford | Fourth | 1½ out |
| » Major-league debuts: Von McDaniel (Cardinals) |
| Friday, June 14 |
| » Lost to Dodgers (30-22), 2-1 | Ebbets Field (1-2) | 28-23 | Lost 2 |
| » Starters: Lindy McDaniel vs Don Newcombe | Fifth | 2½ out |
| » Major-league debuts: Johnny Roseboro (Dodgers) |
| Saturday, June 15 |
| » Defeated Dodgers (30-23), 6-5 | Ebbets Field (2-2) | 29-23 | |
| » Starters: Sam Jones vs Roger Craig | Fourth | 2½ out |
| Sunday, June 16 |
| » Defeated Dodgers (30-24), 7-6 | Ebbets Field (3-2) | 30-23 | Won 2 |
| » Starters: Murry Dickson vs Don Drysdale | Second | 1½ out |
| » Defeated Dodgers (30-25), 8-4 | Ebbets Field (4-2) | 31-23 | Won 3 |
| » Starters: Willard Schmidt vs Johnny Podres | Second | 1½ out |
| Monday, June 17 |
| » Major-league debuts: Danny McDevitt (Dodgers) |
| Tuesday, June 18 |
| » Lost to Pirates (23-35), 8-1 | Sportsman's Park III (7-14) | 31-24 | |
| » Starters: Red Swanson vs Larry Jackson | Second | 1 out |
| Wednesday, June 19 |
| » Defeated Pirates (23-36), 5-2 | Sportsman's Park III (8-14) | 32-24 | |
| » Starters: Ron Kline vs Sam Jones | Second | ½ out |
| » Defeated Pirates (23-37), 5-1 | Sportsman's Park III (9-14) | 33-24 | Won 2 |
| » Starters: Bob Purkey vs Lindy McDaniel | Second | ½ out |
| Thursday, June 20 |
| » Defeated Pirates (23-38), 7-4 | Sportsman's Park III (10-14) | 34-24 | Won 3 |
| » Starters: Luis Arroyo vs Murry Dickson | First | -- |
| Former Cardinal Cy Warmoth dies in Mt.Carmel, IL at the age of 65. |
| Friday, June 21 |
| » Defeated Dodgers (32-28), 2-0 | Sportsman's Park III (11-14) | 35-24 | Won 4 |
| » Starters: Danny McDevitt vs Von McDaniel | First | -- |
| Saturday, June 22 |
| » Lost to Dodgers (33-28), 6-4 | Sportsman's Park III (11-15) | 35-25 | |
| » Starters: Don Newcombe vs Willard Schmidt | First | -- |
| Sunday, June 23 |
| » Defeated Dodgers (33-29), 4-3 | Sportsman's Park III (12-15) | 36-25 | |
| » Starters: Don Drysdale vs Larry Jackson | First | -- |
| Monday, June 24 |
| » Lost to Dodgers (34-29), 10-3 | Sportsman's Park III (12-16) | 36-26 | |
| » Starters: Carl Erskine vs Sam Jones | First | -- |
| Wednesday, June 26 |
| » Lost to Phillies (36-29), 11-3 | Sportsman's Park III (12-17) | 36-27 | Lost 2 |
| » Starters: Curt Simmons vs Lindy McDaniel | First | -- |
| » Major-league debuts: Bob Miller (Cardinals) |
| Thursday, June 27 |
| » Defeated Phillies (36-30), 6-4 | Sportsman's Park III (13-17) | 37-27 | |
| » Starters: Jack Sanford vs Von McDaniel | First | -- |
| Friday, June 28 |
| » Lost to Giants (34-35), 4-1 | Sportsman's Park III (13-18) | 37-28 | |
| » Starters: Curt Barclay vs Larry Jackson | Second | 1½ out |
| Saturday, June 29 |
| » Lost to Giants (35-35), 1-0 | Sportsman's Park III (13-19) | 37-29 | Lost 2 |
| » Starters: Stu Miller vs Sam Jones | Third | 1½ out |
| Sunday, June 30 |
| » Lost to Giants (36-35), 5-3 | Sportsman's Park III (13-20) | 37-30 | Lost 3 |
| » Starters: Ruben Gomez vs Vinegar Bend Mizell | Third | 2½ out |
| » Defeated Giants (36-36), 7-1 | Sportsman's Park III (14-20) | 38-30 | |
| » Starters: Ray Crone vs Lindy McDaniel | Third | 2½ out |
| Monday, July 1 |
| » Defeated Braves (42-30), 9-5 | Sportsman's Park III (15-20) | 39-30 | Won 2 |
| » Starters: Bob Buhl vs Murry Dickson | Third | 1½ out |
| Tuesday, July 2 |
| » Defeated Braves (42-31), 4-2 | Sportsman's Park III (16-20) | 40-30 | Won 3 |
| » Starters: Warren Spahn vs Von McDaniel | Third | 2 out |
| Wednesday, July 3 |
| » Defeated Cubs (23-44), 5-4 | Wrigley Field (3-0) | 41-30 | Won 4 |
| » Starters: Larry Jackson vs Tom Poholsky | Second | 2 out |
| Thursday, July 4 |
| » Lost to Cubs (24-44), 7-6 | Wrigley Field (3-1) | 41-31 | |
| » Starters: Lindy McDaniel vs Bob Rush | Second | 1½ out |
| » Defeated Cubs (24-45), 4-3 | Wrigley Field (4-1) | 42-31 | |
| » Starters: Sam Jones vs Moe Drabowsky | Second | 1½ out |
| Friday, July 5 |
| » Defeated Reds (44-33), 4-3 | Sportsman's Park III (17-20) | 43-31 | Won 2 |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | First | -- |
| Saturday, July 6 |
| » Defeated Reds (44-34), 13-3 | Sportsman's Park III (18-20) | 44-31 | Won 3 |
| » Starters: Johnny Klippstein vs Murry Dickson | First | -- |
| » Major-league debuts: Claude Osteen (Reds) |
| Sunday, July 7 |
| » Defeated Reds (44-35), 3-2 | Sportsman's Park III (19-20) | 45-31 | Won 4 |
| » Starters: Brooks Lawrence vs Von McDaniel | First | -- |
| » Defeated Reds (44-36), 9-6 | Sportsman's Park III (20-20) | 46-31 | Won 5 |
| » Starters: Hal Jeffcoat vs Larry Jackson | First | -- |
| Thursday, July 11 |
| » Lost to Giants (38-43), 1-0 | Polo Grounds V (5-2) | 46-32 | |
| » Starters: Lindy McDaniel vs Johnny Antonelli | First | -- |
| Friday, July 12 |
| » Defeated Giants (38-44), 5-1 | Polo Grounds V (6-2) | 47-32 | |
| » Starters: Sam Jones vs Ruben Gomez | First | -- |
| Sunday, July 14 |
| » Lost to Phillies (46-36), 6-2 | Shibe Park (4-2) | 47-33 | |
| » Starters: Von McDaniel vs Curt Simmons | First | -- |
| » Lost to Phillies (47-36), 11-4 | Shibe Park (4-3) | 47-34 | Lost 2 |
| » Starters: Larry Jackson vs Jim Hearn | First | -- |
| Monday, July 15 |
| » Lost to Phillies (48-36), 6-2 | Shibe Park (4-4) | 47-35 | Lost 3 |
| » Starters: Vinegar Bend Mizell vs Jack Sanford | First | -- |
| Tuesday, July 16 |
| » Lost to Dodgers (46-36), 7-5 | Ebbets Field (4-3) | 47-36 | Lost 4 |
| » Starters: Lindy McDaniel vs Danny McDevitt | First | -- |
| Wednesday, July 17 |
| » Defeated Dodgers (46-37), 7-3 | Ebbets Field (5-3) | 48-36 | |
| » Starters: Sam Jones vs Don Newcombe | First | -- |
| Thursday, July 18 |
| » Lost to Dodgers (47-37), 10-9 | Ebbets Field (5-4) | 48-37 | |
| » Starters: Larry Jackson vs Johnny Podres | Second | 1 out |
| Friday, July 19 |
| » Lost to Pirates (34-55), 7-0 | Forbes Field (4-2) | 48-38 | Lost 2 |
| » Starters: Von McDaniel vs Vern Law | Third | 2 out |
| Saturday, July 20 |
| » Defeated Pirates (34-56), 9-4 | Forbes Field (5-2) | 49-38 | |
| » Starters: Murry Dickson vs Bob Friend | Third | 2 out |
| Sunday, July 21 |
| » Defeated Pirates (34-57), 7-3 | Forbes Field (6-2) | 50-38 | Won 2 |
| » Starters: Herm Wehmeier vs Ron Kline | Second | 1 out |
| » Defeated Pirates (34-58), 11-2 | Forbes Field (7-2) | 51-38 | Won 3 |
| » Starters: Lindy McDaniel vs Bob Purkey | Second | 1 out |
| Tuesday, July 23 |
| » Lost to Dodgers (52-38), 1-0 | Sportsman's Park III (20-21) | 51-39 | |
| » Starters: Johnny Podres vs Sam Jones | Third | 2 out |
| Wednesday, July 24 |
| » Defeated Dodgers (52-39), 3-0 | Sportsman's Park III (21-21) | 52-39 | |
| » Starters: Sal Maglie vs Larry Jackson | Second | 1 out |
| Thursday, July 25 |
| » Defeated Dodgers (52-40), 3-2 | Sportsman's Park III (22-21) | 53-39 | Won 2 |
| » Starters: Don Newcombe vs Herm Wehmeier | First | -- |
| Friday, July 26 |
| » Defeated Pirates (35-61), 4-3 | Sportsman's Park III (23-21) | 54-39 | Won 3 |
| » Starters: Roy Face vs Lindy McDaniel | First | -- |
| Saturday, July 27 |
| » Lost to Pirates (36-61), 4-2 | Sportsman's Park III (23-22) | 54-40 | |
| » Starters: Bob Purkey vs Murry Dickson | Second | 1 out |
| Future Cardinal Floyd Rayford is born in Memphis, TN. |
| Sunday, July 28 |
| » Defeated Pirates (36-62), 4-0 | Sportsman's Park III (24-22) | 55-40 | |
| » Starters: Vern Law vs Von McDaniel | First | -- |
| » Defeated Pirates (36-63), 9-8 | Sportsman's Park III (25-22) | 56-40 | Won 2 |
| » Starters: Bob Friend vs Larry Jackson | First | -- |
| Monday, July 29 |
| » Defeated Pirates (36-64), 4-0 | Sportsman's Park III (26-22) | 57-40 | Won 3 |
| » Starters: Whammy Douglas vs Vinegar Bend Mizell | First | -- |
| Former Cardinal Tommy Thevenow dies in Madison, IN at the age of 54. |
| Tuesday, July 30 |
| » Defeated Giants (44-56), 7-3 | Sportsman's Park III (27-22) | 58-40 | Won 4 |
| » Starters: Ruben Gomez vs Lindy McDaniel | First | -- |
| Future Cardinal Clint Hurdle is born in Big Rapids, MI. |
| Wednesday, July 31 |
| » Defeated Giants (44-57), 5-1 | Sportsman's Park III (28-22) | 59-40 | Won 5 |
| » Starters: Ray Crone vs Herm Wehmeier | First | -- |
| Future Cardinal Leon Durham is born in Cincinnati, OH. |
| Thursday, August 1 |
| » Defeated Giants (44-58), 8-0 | Sportsman's Park III (29-22) | 60-40 | Won 6 |
| » Starters: Johnny Antonelli vs Sam Jones | First | -- |
| Friday, August 2 |
| » Defeated Phillies (56-47), 5-4 | Sportsman's Park III (30-22) | 61-40 | Won 7 |
| » Starters: Jack Sanford vs Larry Jackson | First | -- |
| Saturday, August 3 |
| » Defeated Phillies (56-48), 3-1 | Sportsman's Park III (31-22) | 62-40 | Won 8 |
| » Starters: Robin Roberts vs Von McDaniel | First | -- |
| » Major-league debuts: Billy Muffett (Cardinals) |
| Sunday, August 4 |
| » Lost to Phillies (57-48), 5-4 | Sportsman's Park III (31-23) | 62-41 | |
| » Starters: Jack Meyer vs Vinegar Bend Mizell | First | -- |
| » Defeated Phillies (57-49), 4-1 | Sportsman's Park III (32-23) | 63-41 | |
| » Starters: Warren Hacker vs Lindy McDaniel | First | -- |
| Tuesday, August 6 |
| » Lost to Cubs (37-66), 8-2 | Sportsman's Park III (32-24) | 63-42 | |
| » Starters: Bob Rush vs Sam Jones | First | -- |
| Future Cardinal Bob Horner is born in Junction City, KS. |
| Wednesday, August 7 |
| » Lost to Cubs (38-66), 5-1 | Sportsman's Park III (32-25) | 63-43 | Lost 2 |
| » Starters: Dick Drott vs Herm Wehmeier | Second | 1 out |
| Thursday, August 8 |
| » Lost to Cubs (39-66), 4-3 | Sportsman's Park III (32-26) | 63-44 | Lost 3 |
| » Starters: Moe Drabowsky vs Vinegar Bend Mizell | Second | 2 out |
| Friday, August 9 |
| » Lost to Braves (66-42), 13-2 | Sportsman's Park III (32-27) | 63-45 | Lost 4 |
| » Starters: Bob Buhl vs Lindy McDaniel | Second | 3 out |
| Saturday, August 10 |
| » Lost to Braves (67-42), 9-0 | Sportsman's Park III (32-28) | 63-46 | Lost 5 |
| » Starters: Warren Spahn vs Von McDaniel | Second | 4 out |
| Sunday, August 11 |
| » Lost to Braves (68-42), 5-1 | Sportsman's Park III (32-29) | 63-47 | Lost 6 |
| » Starters: Gene Conley vs Sam Jones | Second | 5 out |
| Tuesday, August 13 |
| » Lost to Cubs (40-69), 6-2 | Wrigley Field (4-2) | 63-48 | Lost 7 |
| » Starters: Herm Wehmeier vs Bob Rush | Second | 6 out |
| Wednesday, August 14 |
| » Lost to Cubs (41-69), 3-1 | Wrigley Field (4-3) | 63-49 | Lost 8 |
| » Starters: Vinegar Bend Mizell vs Dick Drott | Second | 7 out |
| Thursday, August 15 |
| » Lost to Cubs (42-69), 4-1 | Wrigley Field (4-4) | 63-50 | Lost 9 |
| » Starters: Sam Jones vs Moe Drabowsky | Second | 8 out |
| Friday, August 16 |
| » Defeated Braves (71-43), 6-2 | County Stadium (3-2) | 64-50 | |
| » Starters: Lindy McDaniel vs Gene Conley | Second | 7 out |
| Saturday, August 17 |
| » Lost to Braves (72-43), 5-4 | County Stadium (3-3) | 64-51 | |
| » Starters: Larry Jackson vs Lew Burdette | Second | 8 out |
| Sunday, August 18 |
| » Defeated Braves (72-44), 8-6 | County Stadium (4-3) | 65-51 | |
| » Starters: Herm Wehmeier vs Bob Buhl | Second | 6 out |
| » Defeated Braves (72-45), 6-0 | County Stadium (5-3) | 66-51 | Won 2 |
| » Starters: Vinegar Bend Mizell vs Bob Trowbridge | Second | 6 out |
| Tuesday, August 20 |
| » Defeated Giants (56-65), 4-3 | Polo Grounds V (7-2) | 67-51 | Won 3 |
| » Starters: Sam Jones vs Curt Barclay | Second | 5½ out |
| » Defeated Giants (56-66), 3-2 | Polo Grounds V (8-2) | 68-51 | Won 4 |
| » Starters: Von McDaniel vs Johnny Antonelli | Second | 5½ out |
| Wednesday, August 21 |
| » Lost to Giants (57-66), 13-6 | Polo Grounds V (8-3) | 68-52 | |
| » Starters: Lindy McDaniel vs Stu Miller | Second | 6 out |
| Thursday, August 22 |
| » Defeated Phillies (61-59), 6-5 | Shibe Park (5-4) | 69-52 | |
| » Starters: Larry Jackson vs Jack Sanford | Second | 6 out |
| Friday, August 23 |
| » Lost to Phillies (62-59), 3-2 | Shibe Park (5-5) | 69-53 | |
| » Starters: Vinegar Bend Mizell vs Harvey Haddix | Second | 6 out |
| Saturday, August 24 |
| » Defeated Phillies (62-60), 5-2 | Shibe Park (6-5) | 70-53 | |
| » Starters: Herm Wehmeier vs Curt Simmons | Second | 6 out |
| Sunday, August 25 |
| » Lost to Dodgers (70-55), 6-5 | Ebbets Field (5-5) | 70-54 | |
| » Starters: Sam Jones vs Don Drysdale | Second | 7 out |
| Tuesday, August 27 |
| » Lost to Pirates (47-77), 2-1 | Forbes Field (7-3) | 70-55 | Lost 2 |
| » Starters: Von McDaniel vs Bob Friend | Second | 7½ out |
| Wednesday, August 28 |
| » Lost to Pirates (48-77), 2-0 | Forbes Field (7-4) | 70-56 | Lost 3 |
| » Starters: Larry Jackson vs Ron Kline | Third | 7½ out |
| Friday, August 30 |
| » Defeated Cubs (49-75), 2-1 | Wrigley Field (5-4) | 71-56 | |
| » Starters: Vinegar Bend Mizell vs Moe Drabowsky | Third | 7½ out |
| Saturday, August 31 |
| » Defeated Cubs (49-76), 3-2 | Wrigley Field (6-4) | 72-56 | Won 2 |
| » Starters: Herm Wehmeier vs Don Elston | Third | 7½ out |
| Sunday, September 1 |
| » Defeated Cubs (49-77), 3-2 | Wrigley Field (7-4) | 73-56 | Won 3 |
| » Starters: Sam Jones vs Dick Drott | Second | 6½ out |
| Future Cardinal Dave Rucker is born in San Bernardino, CA. |
| Monday, September 2 |
| » Lost to Reds (66-64), 10-5 | Crosley Field (3-3) | 73-57 | |
| » Starters: Von McDaniel vs Hal Jeffcoat | Second | 8½ out |
| » Lost to Reds (67-64), 3-1 | Crosley Field (3-4) | 73-58 | Lost 2 |
| » Starters: Larry Jackson vs Don Gross | Second | 8½ out |
| Tuesday, September 3 |
| » Defeated Reds (67-65), 14-4 | Crosley Field (4-4) | 74-58 | |
| » Starters: Vinegar Bend Mizell vs Joe Nuxhall | Second | 8½ out |
| » Major-league debuts: Jay Hook (Reds) |
| Wednesday, September 4 |
| » Defeated Braves (82-50), 5-4 | Sportsman's Park III (33-29) | 75-58 | Won 2 |
| » Starters: Juan Pizarro vs Herm Wehmeier | Second | 7½ out |
| Thursday, September 5 |
| » Defeated Braves (82-51), 10-1 | Sportsman's Park III (34-29) | 76-58 | Won 3 |
| » Starters: Lew Burdette vs Sam Jones | Second | 6½ out |
| Friday, September 6 |
| » Lost to Reds (70-66), 5-4 | Sportsman's Park III (34-30) | 76-59 | |
| » Starters: Don Gross vs Larry Jackson | Second | 6½ out |
| Saturday, September 7 |
| » Defeated Reds (70-67), 7-4 | Sportsman's Park III (35-30) | 77-59 | |
| » Starters: Hal Jeffcoat vs Von McDaniel | Second | 6½ out |
| Sunday, September 8 |
| » Defeated Reds (70-68), 4-3 | Sportsman's Park III (36-30) | 78-59 | Won 2 |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Second | 5½ out |
| Monday, September 9 |
| Former Cardinal Ed Karger dies in Delta, CO at the age of 75. |
| Tuesday, September 10 |
| » Defeated Phillies (70-70), 4-3 | Sportsman's Park III (37-30) | 79-59 | Won 3 |
| » Starters: Curt Simmons vs Sam Jones | Second | 5½ out |
| » Major-league debuts: Gene Green (Cardinals) |
| Wednesday, September 11 |
| » Defeated Phillies (70-71), 14-6 | Sportsman's Park III (38-30) | 80-59 | Won 4 |
| » Starters: Harvey Haddix vs Herm Wehmeier | Second | 4½ out |
| Friday, September 13 |
| » Lost to Giants (68-75), 7-3 | Sportsman's Park III (38-31) | 80-60 | |
| » Starters: Ruben Gomez vs Larry Jackson | Second | 5 out |
| Saturday, September 14 |
| » Defeated Giants (68-76), 6-1 | Sportsman's Park III (39-31) | 81-60 | |
| » Starters: Johnny Antonelli vs Vinegar Bend Mizell | Second | 4 out |
| Sunday, September 15 |
| » Defeated Pirates (58-87), 9-6 | Sportsman's Park III (40-31) | 82-60 | Won 2 |
| » Starters: Ron Kline vs Herm Wehmeier | Second | 2½ out |
| » Defeated Pirates (58-88), 11-3 | Sportsman's Park III (41-31) | 83-60 | Won 3 |
| » Starters: Red Swanson vs Sam Jones | Second | 2½ out |
| Tuesday, September 17 |
| » Defeated Dodgers (80-66), 12-5 | Sportsman's Park III (42-31) | 84-60 | Won 4 |
| » Starters: Danny McDevitt vs Larry Jackson | Second | 3 out |
| Wednesday, September 18 |
| » Lost to Dodgers (81-66), 6-1 | Sportsman's Park III (42-32) | 84-61 | |
| » Starters: Don Drysdale vs Lindy McDaniel | Second | 4 out |
| Friday, September 20 |
| » Defeated Reds (76-70), 7-5 | Crosley Field (5-4) | 85-61 | |
| » Starters: Vinegar Bend Mizell vs Don Gross | Second | 4 out |
| Saturday, September 21 |
| » Lost to Reds (77-70), 9-8 | Crosley Field (5-5) | 85-62 | |
| » Starters: Sam Jones vs Joe Nuxhall | Second | 5 out |
| » Major-league debuts: Charlie Rabe (Reds) |
| Sunday, September 22 |
| » Defeated Reds (77-71), 7-5 | Crosley Field (6-5) | 86-62 | |
| » Starters: Lindy McDaniel vs Brooks Lawrence | Second | 5 out |
| » Major-league debuts: Bobby Durnbaugh (Reds) Frank Barnes (Cardinals) |
| Monday, September 23 |
| » Lost to Braves (92-57), 4-2 | County Stadium (5-4) | 86-63 | |
| » Starters: Vinegar Bend Mizell vs Lew Burdette | Second | 6 out |
| Future Cardinal Tony Fossas is born in Havana, Cuba. |
| Tuesday, September 24 |
| » Lost to Braves (93-57), 6-1 | County Stadium (5-5) | 86-64 | Lost 2 |
| » Starters: Sam Jones vs Warren Spahn | Second | 7 out |
| Wednesday, September 25 |
| » Defeated Braves (93-58), 4-1 | County Stadium (6-5) | 87-64 | |
| » Starters: Lindy McDaniel vs Bob Buhl |
