| Tuesday, January 31 |
| Former White Sox Buck Weaver dies in Chicago, IL at the age of 66. |
| Sunday, February 19 |
| Former White Sox Ray Demmitt dies in Glen Ellyn, IL at the age of 73. |
| Saturday, February 25 |
| Future White Sox Kevin Hickey is born in Chicago, IL. |
| Saturday, March 17 |
| Future White Sox Tim Lollar is born in Poplar Bluff, MO. |
| Tuesday, April 17 |
| » Defeated Indians (0-1), 2-1 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Bob Lemon vs Billy Pierce | First | -- |
| » Major-league debuts: Luis Aparicio (White Sox) |
| Thursday, April 19 |
| » Defeated Indians (0-2), 1-0 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Herb Score vs Jack Harshman | Second | ½ out |
| » Major-league debuts: Earl Averill (Indians) |
| Friday, April 20 |
| » Defeated Athletics (2-1), 6-3 | Municipal Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Dick Donovan vs Lou Kretlow | First | -- |
| Saturday, April 21 |
| » Lost to Athletics (3-1), 15-1 | Municipal Stadium (1-1) | 3-1 | |
| » Starters: Sandy Consuegra vs Art Ditmar | Second | ½ out |
| Sunday, April 22 |
| » Defeated Athletics (3-2), 3-0 | Municipal Stadium (2-1) | 4-1 | |
| » Starters: Billy Pierce vs Alex Kellner | Second | ½ out |
| Friday, April 27 |
| » Defeated Athletics (3-6), 9-7 | Comiskey Park I (3-0) | 5-1 | Won 2 |
| » Starters: Art Ditmar vs Billy Pierce | First | -- |
| Tuesday, May 1 |
| » Lost to Orioles (5-9), 3-2 | Memorial Stadium (0-1) | 5-2 | |
| » Starters: Jack Harshman vs Erv Palica | Second | 2½ out |
| Thursday, May 3 |
| » Lost to Senators (8-7), 7-4 | Griffith Stadium (0-1) | 5-3 | Lost 2 |
| » Starters: Billy Pierce vs Dean Stone | Second | 3 out |
| Friday, May 4 |
| » Defeated Senators (8-8), 5-2 | Griffith Stadium (1-1) | 6-3 | |
| » Starters: Dick Donovan vs Camilo Pascual | Second | 3 out |
| Saturday, May 5 |
| » Lost to Senators (9-8), 4-2 | Griffith Stadium (1-2) | 6-4 | |
| » Starters: Connie Johnson vs Chuck Stobbs | Third | 3 out |
| Sunday, May 6 |
| » Lost to Yankees (12-5), 4-0 | Yankee Stadium (0-1) | 6-5 | Lost 2 |
| » Starters: Jack Harshman vs Whitey Ford | Third | 4 out |
| » Lost to Yankees (13-5), 4-0 | Yankee Stadium (0-2) | 6-6 | Lost 3 |
| » Starters: Harry Byrd vs Rip Coleman | Third | 4 out |
| Tuesday, May 8 |
| » Lost to Red Sox (9-7), 4-3 | Fenway Park (0-1) | 6-7 | Lost 4 |
| » Starters: Billy Pierce vs Frank Sullivan | Fifth | 5 out |
| Wednesday, May 9 |
| » Lost to Red Sox (10-7), 7-5 | Fenway Park (0-2) | 6-8 | Lost 5 |
| » Starters: Dick Donovan vs Bob Porterfield | Sixth | 5 out |
| Thursday, May 10 |
| » Defeated Red Sox (10-8), 2-1 | Fenway Park (1-2) | 7-8 | |
| » Starters: Connie Johnson vs Mel Parnell | Fourth | 4 out |
| Friday, May 11 |
| » Defeated Tigers (8-13), 9-7 | Tiger Stadium (1-0) | 8-8 | Won 2 |
| » Starters: Jack Harshman vs Frank Lary | Fourth | 4 out |
| Saturday, May 12 |
| » Defeated Tigers (8-14), 7-6 | Tiger Stadium (2-0) | 9-8 | Won 3 |
| » Starters: Dick Donovan vs Billy Hoeft | Third | 3 out |
| Sunday, May 13 |
| » Defeated Tigers (8-15), 8-1 | Tiger Stadium (3-0) | 10-8 | Won 4 |
| » Starters: Billy Pierce vs Virgil Trucks | Third | 3½ out |
| Tuesday, May 15 |
| » Defeated Senators (11-14), 5-1 | Comiskey Park I (4-0) | 11-8 | Won 5 |
| » Starters: Chuck Stobbs vs Bob Keegan | Third | 2½ out |
| Wednesday, May 16 |
| » Defeated Senators (11-15), 3-1 | Comiskey Park I (5-0) | 12-8 | Won 6 |
| » Starters: Hal Griggs vs Dick Donovan | Third | 3½ out |
| Thursday, May 17 |
| » Lost to Yankees (18-10), 10-3 | Comiskey Park I (5-1) | 12-9 | |
| » Starters: Whitey Ford vs Jack Harshman | Third | 3½ out |
| Friday, May 18 |
| » Lost to Yankees (19-10), 8-7 | Comiskey Park I (5-2) | 12-10 | Lost 2 |
| » Starters: Rip Coleman vs Billy Pierce | Fourth | 3½ out |
| Saturday, May 19 |
| » Lost to Yankees (20-10), 6-4 | Comiskey Park I (5-3) | 12-11 | Lost 3 |
| » Starters: Bob Turley vs Howie Pollet | Fourth | 4½ out |
| Future White Sox Luis Salazar is born in Barcelona, Venezuela. |
| Sunday, May 20 |
| » Lost to Red Sox (15-12), 12-5 | Comiskey Park I (5-4) | 12-12 | Lost 4 |
| » Starters: Frank Baumann vs Dick Donovan | Fourth | 6 out |
| » Lost to Red Sox (16-12), 2-1 | Comiskey Park I (5-5) | 12-13 | Lost 5 |
| » Starters: Ike Delock vs Bob Keegan | Fourth | 6 out |
| Wednesday, May 23 |
| » Defeated Orioles (15-18), 3-2 | Comiskey Park I (6-5) | 13-13 | |
| » Starters: Johnny Schmitz vs Jack Harshman | Fourth | 6 out |
| Friday, May 25 |
| » Defeated Indians (19-13), 2-1 | Comiskey Park I (7-5) | 14-13 | Won 2 |
| » Starters: Mike Garcia vs Billy Pierce | Fourth | 6½ out |
| Saturday, May 26 |
| Former White Sox Al Simmons dies in Milwaukee, WI at the age of 55. |
| Sunday, May 27 |
| » Defeated Indians (19-14), 5-4 | Comiskey Park I (8-5) | 15-13 | Won 3 |
| » Starters: Bob Lemon vs Bob Keegan | Fourth | 6 out |
| » Lost to Indians (20-14), 4-2 | Comiskey Park I (8-6) | 15-14 | |
| » Starters: Early Wynn vs Jack Harshman | Fourth | 6 out |
| Monday, May 28 |
| » Lost to Athletics (15-21), 6-4 | Municipal Stadium (2-2) | 15-15 | Lost 2 |
| » Starters: Dick Donovan vs Tom Lasorda | Fourth | 7 out |
| Future White Sox Randy Martz is born in Harrisburg, PA. |
| Tuesday, May 29 |
| » Defeated Athletics (15-22), 7-4 | Municipal Stadium (3-2) | 16-15 | |
| » Starters: Howie Pollet vs Tom Gorman | Fourth | 6 out |
| Wednesday, May 30 |
| » Defeated Indians (20-16), 6-3 | Cleveland Stadium (1-0) | 17-15 | Won 2 |
| » Starters: Billy Pierce vs Art Houtteman | Second | 6 out |
| » Defeated Indians (20-17), 9-8 | Cleveland Stadium (2-0) | 18-15 | Won 3 |
| » Starters: Gerry Staley vs Mike Garcia | Second | 6 out |
| Friday, June 1 |
| » Lost to Orioles (20-21), 3-2 | Memorial Stadium (0-2) | 18-16 | |
| » Starters: Bob Keegan vs Connie Johnson | Second | 6½ out |
| Sunday, June 3 |
| » Defeated Orioles (20-22), 12-0 | Memorial Stadium (1-2) | 19-16 | |
| » Starters: Dick Donovan vs Erv Palica | Second | 4½ out |
| » Defeated Orioles (20-23), 9-2 | Memorial Stadium (2-2) | 20-16 | Won 2 |
| » Starters: Jim Wilson vs Mike Fornieles | Second | 4½ out |
| Monday, June 4 |
| » Defeated Orioles (20-24), 13-4 | Memorial Stadium (3-2) | 21-16 | Won 3 |
| » Starters: Billy Pierce vs Don Ferrarese | Second | 4 out |
| Tuesday, June 5 |
| » Lost to Senators (19-28), 3-1 | Griffith Stadium (1-3) | 21-17 | |
| » Starters: Jack Harshman vs Chuck Stobbs | Third | 4 out |
| Wednesday, June 6 |
| » Lost to Senators (20-28), 12-7 | Griffith Stadium (1-4) | 21-18 | Lost 2 |
| » Starters: Gerry Staley vs Bob Wiesler | Third | 5 out |
| Thursday, June 7 |
| » Defeated Senators (20-29), 7-5 | Griffith Stadium (2-4) | 22-18 | |
| » Starters: Dick Donovan vs Dean Stone | Third | 5 out |
| Friday, June 8 |
| » Lost to Red Sox (24-22), 5-3 | Fenway Park (1-3) | 22-19 | |
| » Starters: Bob Keegan vs Willard Nixon | Third | 5 out |
| Saturday, June 9 |
| » Defeated Red Sox (24-23), 8-0 | Fenway Park (2-3) | 23-19 | |
| » Starters: Jim Wilson vs Ike Delock | Third | 4 out |
| Sunday, June 10 |
| » Defeated Red Sox (24-24), 3-2 | Fenway Park (3-3) | 24-19 | Won 2 |
| » Starters: Billy Pierce vs George Susce | Third | 4 out |
| Tuesday, June 12 |
| » Lost to Yankees (33-19), 4-2 | Yankee Stadium (0-3) | 24-20 | |
| » Starters: Dick Donovan vs Whitey Ford | Third | 5 out |
| Wednesday, June 13 |
| » Defeated Yankees (33-20), 7-5 | Yankee Stadium (1-3) | 25-20 | |
| » Starters: Bob Keegan vs Bob Turley | Second | 4 out |
| Thursday, June 14 |
| » Lost to Yankees (34-20), 5-1 | Yankee Stadium (1-4) | 25-21 | |
| » Starters: Jim Wilson vs Bob Grim | Second | 5 out |
| Friday, June 15 |
| » Defeated Senators (23-35), 7-2 | Comiskey Park I (9-6) | 26-21 | |
| » Starters: Bob Wiesler vs Billy Pierce | Second | 5 out |
| Saturday, June 16 |
| » Defeated Senators (23-36), 7-0 | Comiskey Park I (10-6) | 27-21 | Won 2 |
| » Starters: Hal Griggs vs Jack Harshman | Second | 5 out |
| Sunday, June 17 |
| » Defeated Senators (23-37), 20-2 | Comiskey Park I (11-6) | 28-21 | Won 3 |
| » Starters: Bunky Stewart vs Dick Donovan | Second | 5½ out |
| » Lost to Senators (24-37), 10-4 | Comiskey Park I (11-7) | 28-22 | |
| » Starters: Chuck Stobbs vs Bob Keegan | Second | 5½ out |
| Monday, June 18 |
| » Defeated Orioles (28-30), 5-2 | Comiskey Park I (12-7) | 29-22 | |
| » Starters: Bill Wight vs Jim Wilson | Second | 5½ out |
| Tuesday, June 19 |
| » Defeated Orioles (28-31), 5-1 | Comiskey Park I (13-7) | 30-22 | Won 2 |
| » Starters: Ray Moore vs Billy Pierce | Second | 5½ out |
| Wednesday, June 20 |
| » Defeated Orioles (28-32), 12-8 | Comiskey Park I (14-7) | 31-22 | Won 3 |
| » Starters: Billy Loes vs Howie Pollet | Second | 5½ out |
| Thursday, June 21 |
| » Defeated Orioles (28-33), 1-0 | Comiskey Park I (15-7) | 32-22 | Won 4 |
| » Starters: Connie Johnson vs Jack Harshman | Second | 5 out |
| Friday, June 22 |
| » Defeated Yankees (40-21), 5-4 | Comiskey Park I (16-7) | 33-22 | Won 5 |
| » Starters: Tom Sturdivant vs Dick Donovan | Second | 4 out |
| Saturday, June 23 |
| » Defeated Yankees (40-22), 2-0 | Comiskey Park I (17-7) | 34-22 | Won 6 |
| » Starters: Bob Grim vs Jim Wilson | Second | 3 out |
| Sunday, June 24 |
| » Defeated Yankees (40-23), 14-2 | Comiskey Park I (18-7) | 35-22 | Won 7 |
| » Starters: Whitey Ford vs Billy Pierce | Second | 3 out |
| » Defeated Yankees (40-24), 6-3 | Comiskey Park I (19-7) | 36-22 | Won 8 |
| » Starters: Mickey McDermott vs Gerry Staley | Second | 3 out |
| Tuesday, June 26 |
| » Defeated Red Sox (31-31), 4-1 | Comiskey Park I (20-7) | 37-22 | Won 9 |
| » Starters: Tom Brewer vs Jack Harshman | Second | 3½ out |
| Wednesday, June 27 |
| » Lost to Red Sox (32-31), 11-9 | Comiskey Park I (20-8) | 37-23 | |
| » Starters: Frank Sullivan vs Dick Donovan | Second | 3½ out |
| Friday, June 29 |
| » Lost to Indians (37-27), 5-2 | Cleveland Stadium (2-1) | 37-24 | Lost 2 |
| » Starters: Jim Wilson vs Herb Score | Second | 3 out |
| » Defeated Indians (37-28), 13-2 | Cleveland Stadium (3-1) | 38-24 | |
| » Starters: Billy Pierce vs Bob Lemon | Second | 3 out |
| Saturday, June 30 |
| » Defeated Indians (37-29), 8-3 | Cleveland Stadium (4-1) | 39-24 | Won 2 |
| » Starters: Gerry Staley vs Don Mossi | Second | 3 out |
| Sunday, July 1 |
| » Lost to Indians (38-29), 7-6 | Cleveland Stadium (4-2) | 39-25 | |
| » Starters: Jack Harshman vs Early Wynn | Second | 4 out |
| » Lost to Indians (39-29), 6-1 | Cleveland Stadium (4-3) | 39-26 | Lost 2 |
| » Starters: Dick Donovan vs Bob Lemon | Second | 4 out |
| Monday, July 2 |
| » Defeated Tigers (30-38), 9-3 | Tiger Stadium (4-0) | 40-26 | |
| » Starters: Howie Pollet vs Virgil Trucks | Second | 3½ out |
| Former White Sox Roy Wilkinson dies in Louisville, KY at the age of 64. |
| Tuesday, July 3 |
| » Defeated Tigers (30-39), 6-0 | Tiger Stadium (5-0) | 41-26 | Won 2 |
| » Starters: Jim Wilson vs Billy Hoeft | Second | 3½ out |
| Wednesday, July 4 |
| » Defeated Athletics (26-46), 5-2 | Comiskey Park I (21-8) | 42-26 | Won 3 |
| » Starters: Jack McMahan vs Billy Pierce | Second | 3½ out |
| » Lost to Athletics (27-46), 3-2 | Comiskey Park I (21-9) | 42-27 | |
| » Starters: Alex Kellner vs Gerry Staley | Second | 3½ out |
| Friday, July 6 |
| » Defeated Tigers (31-42), 14-0 | Comiskey Park I (22-9) | 43-27 | |
| » Starters: Steve Gromek vs Jack Harshman | Second | 4 out |
| Saturday, July 7 |
| » Lost to Tigers (32-42), 12-8 | Comiskey Park I (22-10) | 43-28 | |
| » Starters: Billy Hoeft vs Dick Donovan | Second | 5 out |
| Sunday, July 8 |
| » Lost to Tigers (33-42), 17-5 | Comiskey Park I (22-11) | 43-29 | Lost 2 |
| » Starters: Paul Foytack vs Jim Wilson | Second | 6½ out |
| » Lost to Tigers (34-42), 8-6 | Comiskey Park I (22-12) | 43-30 | Lost 3 |
| » Starters: Frank Lary vs Billy Pierce | Second | 6½ out |
| Monday, July 9 |
| Future White Sox Guy Hoffman is born in Ottawa, IL. |
| Thursday, July 12 |
| » Lost to Red Sox (41-35), 3-1 | Fenway Park (3-4) | 43-31 | Lost 4 |
| » Starters: Jack Harshman vs Frank Sullivan | Second | 7½ out |
| Future White Sox Bryan Clark is born in Madera, CA. |
| Friday, July 13 |
| » Lost to Red Sox (42-35), 5-4 | Fenway Park (3-5) | 43-32 | Lost 5 |
| » Starters: Jim Wilson vs Tom Brewer | Second | 8½ out |
| Saturday, July 14 |
| » Lost to Red Sox (43-35), 4-0 | Fenway Park (3-6) | 43-33 | Lost 6 |
| » Starters: Jim McDonald vs Mel Parnell | Second | 9½ out |
| Sunday, July 15 |
| » Lost to Yankees (56-26), 2-1 | Yankee Stadium (1-5) | 43-34 | Lost 7 |
| » Starters: Billy Pierce vs Whitey Ford | Third | 11½ out |
| » Lost to Yankees (57-26), 6-5 | Yankee Stadium (1-6) | 43-35 | Lost 8 |
| » Starters: Dick Donovan vs Rip Coleman | Third | 11½ out |
| Tuesday, July 17 |
| » Lost to Orioles (38-44), 5-3 | Memorial Stadium (3-3) | 43-36 | Lost 9 |
| » Starters: Jack Harshman vs Don Ferrarese | Fourth | 13 out |
| » Lost to Orioles (39-44), 5-3 | Memorial Stadium (3-4) | 43-37 | Lost 10 |
| » Starters: Bob Keegan vs Bill Wight | Fourth | 13 out |
| Wednesday, July 18 |
| » Lost to Orioles (40-44), 4-3 | Memorial Stadium (3-5) | 43-38 | Lost 11 |
| » Starters: Jim Wilson vs Connie Johnson | Fourth | 12½ out |
| Thursday, July 19 |
| » Defeated Orioles (40-45), 3-2 | Memorial Stadium (4-5) | 44-38 | |
| » Starters: Billy Pierce vs Mike Fornieles | Fourth | 12½ out |
| Saturday, July 21 |
| » Lost to Senators (36-54), 6-5 | Griffith Stadium (2-5) | 44-39 | |
| » Starters: Dick Donovan vs Chuck Stobbs | Fourth | 13½ out |
| Sunday, July 22 |
| » Defeated Senators (36-55), 6-1 | Griffith Stadium (3-5) | 45-39 | |
| » Starters: Jack Harshman vs Bob Wiesler | Fourth | 13 out |
| Monday, July 23 |
| » Lost to Athletics (33-56), 3-2 | Comiskey Park I (22-13) | 45-40 | |
| » Starters: Jack McMahan vs Jim Wilson | Fourth | 13½ out |
| Tuesday, July 24 |
| » Defeated Yankees (61-30), 11-5 | Comiskey Park I (23-13) | 46-40 | |
| » Starters: Tom Sturdivant vs Billy Pierce | Fourth | 12½ out |
| Wednesday, July 25 |
| » Lost to Yankees (62-30), 10-1 | Comiskey Park I (23-14) | 46-41 | |
| » Starters: Whitey Ford vs Dick Donovan | Fourth | 13½ out |
| Former White Sox John Kane dies in Chicago, IL at the age of 57. |
| Thursday, July 26 |
| » Lost to Yankees (63-30), 8-5 | Comiskey Park I (23-15) | 46-42 | Lost 2 |
| » Starters: Tommy Byrne vs Jack Harshman | Fourth | 14½ out |
| Friday, July 27 |
| » Lost to Red Sox (52-40), 4-3 | Comiskey Park I (23-16) | 46-43 | Lost 3 |
| » Starters: Tom Brewer vs Jim Wilson | Fourth | 15½ out |
| Saturday, July 28 |
| » Lost to Red Sox (53-40), 13-1 | Comiskey Park I (23-17) | 46-44 | Lost 4 |
| » Starters: Willard Nixon vs Jim McDonald | Fourth | 16½ out |
| Sunday, July 29 |
| » Defeated Red Sox (53-41), 11-2 | Comiskey Park I (24-17) | 47-44 | |
| » Starters: Dave Sisler vs Billy Pierce | Fourth | 16 out |
| » Defeated Red Sox (53-42), 6-3 | Comiskey Park I (25-17) | 48-44 | Won 2 |
| » Starters: Mel Parnell vs Jack Harshman | Fourth | 16 out |
| Tuesday, July 31 |
| » Lost to Senators (39-60), 4-3 | Comiskey Park I (25-18) | 48-45 | |
| » Starters: Pedro Ramos vs Dick Donovan | Fourth | 16½ out |
| Wednesday, August 1 |
| » Lost to Senators (40-60), 6-2 | Comiskey Park I (25-19) | 48-46 | Lost 2 |
| » Starters: Chuck Stobbs vs Jim Wilson | Fourth | 16½ out |
| Thursday, August 2 |
| » Defeated Senators (40-61), 5-4 | Comiskey Park I (26-19) | 49-46 | |
| » Starters: Bob Wiesler vs Bob Keegan | Fourth | 15½ out |
| Friday, August 3 |
| » Defeated Orioles (45-56), 13-3 | Comiskey Park I (27-19) | 50-46 | Won 2 |
| » Starters: Johnny Schmitz vs Billy Pierce | Fourth | 14½ out |
| Saturday, August 4 |
| » Defeated Orioles (45-57), 15-4 | Comiskey Park I (28-19) | 51-46 | Won 3 |
| » Starters: Bill Wight vs Jack Harshman | Fourth | 13½ out |
| Sunday, August 5 |
| » Lost to Orioles (46-57), 5-4 | Comiskey Park I (28-20) | 51-47 | |
| » Starters: Don Ferrarese vs Dick Donovan | Fourth | 14 out |
| » Lost to Orioles (47-57), 7-2 | Comiskey Park I (28-21) | 51-48 | Lost 2 |
| » Starters: Ray Moore vs Jim Wilson | Fourth | 14 out |
| Monday, August 6 |
| » Major-league debuts: Ralph Terry (Yankees) |
| Tuesday, August 7 |
| » Defeated Athletics (36-67), 5-4 | Comiskey Park I (29-21) | 52-48 | |
| » Starters: Alex Kellner vs Bob Keegan | Fourth | 13 out |
| » Defeated Athletics (36-68), 4-3 | Comiskey Park I (30-21) | 53-48 | Won 2 |
| » Starters: Lou Kretlow vs Jim McDonald | Fourth | 13 out |
| Wednesday, August 8 |
| » Defeated Indians (60-44), 7-6 | Comiskey Park I (31-21) | 54-48 | Won 3 |
| » Starters: Hank Aguirre vs Billy Pierce | Fourth | 13 out |
| Thursday, August 9 |
| » Defeated Indians (60-45), 9-2 | Comiskey Park I (32-21) | 55-48 | Won 4 |
| » Starters: Early Wynn vs Jack Harshman | Fourth | 13 out |
| Friday, August 10 |
| » Defeated Tigers (50-58), 6-1 | Tiger Stadium (6-0) | 56-48 | Won 5 |
| » Starters: Dick Donovan vs Paul Foytack | Fourth | 13 out |
| Saturday, August 11 |
| » Lost to Tigers (51-58), 5-1 | Tiger Stadium (6-1) | 56-49 | |
| » Starters: Jim Wilson vs Frank Lary | Fourth | 13 out |
| Sunday, August 12 |
| » Lost to Tigers (52-58), 5-2 | Tiger Stadium (6-2) | 56-50 | Lost 2 |
| » Starters: Billy Pierce vs Billy Hoeft | Fourth | 14½ out |
| Tuesday, August 14 |
| » Defeated Athletics (37-73), 12-1 | Municipal Stadium (4-2) | 57-50 | |
| » Starters: Jack Harshman vs Art Ditmar | Fourth | 14½ out |
| Wednesday, August 15 |
| » Defeated Athletics (37-74), 10-0 | Municipal Stadium (5-2) | 58-50 | Won 2 |
| » Starters: Dick Donovan vs Wally Burnette | Fourth | 14½ out |
| Thursday, August 16 |
| » Defeated Athletics (37-75), 6-5 | Municipal Stadium (6-2) | 59-50 | Won 3 |
| » Starters: Jim Wilson vs Alex Kellner | Fourth | 13½ out |
| Friday, August 17 |
| » Defeated Tigers (54-60), 4-3 | Comiskey Park I (33-21) | 60-50 | Won 4 |
| » Starters: Virgil Trucks vs Billy Pierce | Fourth | 12½ out |
| Saturday, August 18 |
| » Defeated Tigers (54-61), 2-1 | Comiskey Park I (34-21) | 61-50 | Won 5 |
| » Starters: Paul Foytack vs Bob Keegan | Fourth | 13 out |
| Sunday, August 19 |
| » Lost to Tigers (55-61), 3-1 | Comiskey Park I (34-22) | 61-51 | |
| » Starters: Frank Lary vs Jack Harshman | Third | 12½ out |
| » Defeated Tigers (55-62), 4-1 | Comiskey Park I (35-22) | 62-51 | |
| » Starters: Billy Hoeft vs Dick Donovan | Third | 12½ out |
| Wednesday, August 22 |
| » Defeated Red Sox (63-54), 6-3 | Fenway Park (4-6) | 63-51 | Won 2 |
| » Starters: Billy Pierce vs Willard Nixon | Third | 12½ out |
| » Lost to Red Sox (64-54), 7-6 | Fenway Park (4-7) | 63-52 | |
| » Starters: Jim Wilson vs Frank Sullivan | Third | 12½ out |
| Thursday, August 23 |
| » Defeated Yankees (78-43), 8-3 | Yankee Stadium (2-6) | 64-52 | |
| » Starters: Bob Keegan vs Rip Coleman | Third | 10½ out |
| » Defeated Yankees (78-44), 6-4 | Yankee Stadium (3-6) | 65-52 | Won 2 |
| » Starters: Dixie Howell vs Bob Turley | Third | 10½ out |
| Friday, August 24 |
| » Lost to Yankees (79-44), 2-0 | Yankee Stadium (3-7) | 65-53 | |
| » Starters: Jack Harshman vs Johnny Kucks | Third | 11½ out |
| Future White Sox Tony Bernazard is born in Caguas, P.R. |
| Saturday, August 25 |
| » Defeated Yankees (79-45), 4-2 | Yankee Stadium (4-7) | 66-53 | |
| » Starters: Dick Donovan vs Whitey Ford | Third | 10½ out |
| Sunday, August 26 |
| » Lost to Orioles (55-67), 8-1 | Memorial Stadium (4-6) | 66-54 | |
| » Starters: Billy Pierce vs Bill Wight | Third | 10½ out |
| » Defeated Orioles (55-68), 5-1 | Memorial Stadium (5-6) | 67-54 | |
| » Starters: Gerry Staley vs Hal Brown | Third | 10½ out |
| Tuesday, August 28 |
| » Lost to Senators (52-71), 6-2 | Griffith Stadium (3-6) | 67-55 | |
| » Starters: Bob Keegan vs Chuck Stobbs | Third | 11 out |
| » Defeated Senators (52-72), 5-3 | Griffith Stadium (4-6) | 68-55 | |
| » Starters: Jack Harshman vs Pedro Ramos | Third | 11 out |
| Wednesday, August 29 |
| » Defeated Senators (52-73), 9-7 | Griffith Stadium (5-6) | 69-55 | Won 2 |
| » Starters: Jim Wilson vs Bob Wiesler | Third | 11 out |
| Friday, August 31 |
| » Lost to Indians (73-52), 3-2 | Comiskey Park I (35-23) | 69-56 | |
| » Starters: Herb Score vs Billy Pierce | Third | 11½ out |
| » Defeated Indians (73-53), 1-0 | Comiskey Park I (36-23) | 70-56 | |
| » Starters: Early Wynn vs Dick Donovan | Third | 11½ out |
| Saturday, September 1 |
| » Lost to Indians (74-53), 5-1 | Comiskey Park I (36-24) | 70-57 | |
| » Starters: Bob Lemon vs Gerry Staley | Third | 11½ out |
| Sunday, September 2 |
| » Defeated Indians (74-54), 4-3 | Comiskey Park I (37-24) | 71-57 | |
| » Starters: Hank Aguirre vs Jack Harshman | Third | 10½ out |
| Monday, September 3 |
| » Lost to Tigers (65-65), 11-8 | Comiskey Park I (37-25) | 71-58 | |
| » Starters: Jim Bunning vs Jim Wilson | Third | 11½ out |
| » Defeated Tigers (65-66), 5-3 | Comiskey Park I (38-25) | 72-58 | |
| » Starters: Steve Gromek vs Bob Keegan | Third | 11½ out |
| Tuesday, September 4 |
| » Defeated Tigers (65-67), 11-4 | Comiskey Park I (39-25) | 73-58 | Won 2 |
| » Starters: Paul Foytack vs Dick Donovan | Third | 11 out |
| Former White Sox Pat Ragan dies in Los Angeles, CA at the age of 68. |
| Friday, September 7 |
| » Defeated Indians (75-57), 2-1 | Cleveland Stadium (5-3) | 74-58 | Won 3 |
| » Starters: Jack Harshman vs Bob Lemon | Third | 10½ out |
| Saturday, September 8 |
| » Defeated Indians (75-58), 4-2 | Cleveland Stadium (6-3) | 75-58 | Won 4 |
| » Starters: Billy Pierce vs Early Wynn | Second | 10½ out |
| Sunday, September 9 |
| » Lost to Indians (76-58), 4-1 | Cleveland Stadium (6-4) | 75-59 | |
| » Starters: Dick Donovan vs Herb Score | Second | 11 out |
| » Defeated Indians (76-59), 6-2 | Cleveland Stadium (7-4) | 76-59 | |
| » Starters: Gerry Staley vs Hank Aguirre | Second | 11 out |
| Tuesday, September 11 |
| » Lost to Red Sox (76-61), 5-3 | Comiskey Park I (39-26) | 76-60 | |
| » Starters: Willard Nixon vs Bob Keegan | Third | 12 out |
| Wednesday, September 12 |
| » Lost to Red Sox (77-61), 4-1 | Comiskey Park I (39-27) | 76-61 | Lost 2 |
| » Starters: Frank Sullivan vs Jack Harshman | Fourth | 12 out |
| Thursday, September 13 |
| » Defeated Red Sox (77-62), 4-3 | Comiskey Park I (40-27) | 77-61 | |
| » Starters: Tom Brewer vs Billy Pierce | Third | 12 out |
| Friday, September 14 |
| » Defeated Orioles (60-80), 3-2 | Comiskey Park I (41-27) | 78-61 | Won 2 |
| » Starters: Bill Wight vs Dick Donovan | Third | 12 out |
| Saturday, September 15 |
| » Lost to Orioles (61-80), 4-1 | Comiskey Park I (41-28) | 78-62 | |
| » Starters: Billy O'Dell vs Jim Wilson | Third | 12 out |
| Sunday, September 16 |
| » Defeated Senators (58-84), 7-5 | Comiskey Park I (42-28) | 79-62 | |
| » Starters: Evelio Hernandez vs Jack Harshman | Second | 11 out |
| » Defeated Senators (58-85), 7-2 | Comiskey Park I (43-28) | 80-62 | Won 2 |
| » Starters: Dick Brodowski vs Gerry Staley | Second | 11 out |
| Monday, September 17 |
| Future White Sox Thad Bosley is born in Oceanside, CA. |
| Tuesday, September 18 |
| » Lost to Yankees (93-52), 3-2 | Comiskey Park I (43-29) | 80-63 | |
| » Starters: Whitey Ford vs Billy Pierce | Third | 12 out |
| Wednesday, September 19 |
| » Major-league debuts: Gordie Sundin (Orioles) |
| Friday, September 21 |
| » Defeated Athletics (48-97), 4-2 | Comiskey Park I (44-29) | 81-63 | |
| » Starters: Glenn Cox vs Jack Harshman | Third | 11½ out |
| » Lost to Athletics (49-97), 3-2 | Comiskey Park I (44-30) | 81-64 | |
| » Starters: Art Ditmar vs Dick Donovan | Third | 11½ out |
| Saturday, September 22 |
| » Defeated Athletics (49-98), 17-3 | Comiskey Park I (45-30) | 82-64 | |
| » Starters: Carl Duser vs Jim Wilson | Third | 11½ out |
| Sunday, September 23 |
| » Lost to Athletics (50-98), 3-2 | Comiskey Park I (45-31) | 82-65 | |
| » Starters: Tom Gorman vs Billy Pierce | Third | 12 out |
| » Defeated Athletics (50-99), 5-1 | Comiskey Park I (46-31) | 83-65 | |
| » Starters: Walt Craddock vs Gerry Staley | Third | 12 out |
| Monday, September 24 |
| » Defeated Tigers (78-71), 14-11 | Tiger Stadium (7-2) | 84-65 | Won 2 |
| » Starters: Bob Keegan vs Hal Woodeshick | Third | 11 out |
| Tuesday, September 25 |
| » Lost to Tigers (79-71), 5-3 | Tiger Stadium (7-3) | 84-66 | |
| » Starters: Dick Donovan vs Billy Hoeft | Third | 12 out |
| Wednesday, September 26 |
| » Lost to Tigers (80-71), 4-1 | Tiger Stadium (7-4) | 84-67 | Lost 2 |
| » Starters: Jack Harshman vs Paul Foytack | Third | 12 out |
| Friday, September 28 |
| » Lost to Athletics (51-101), 6-5 | Municipal Stadium (6-3) | 84-68 | Lost 3 |
| » Starters: Billy Pierce vs Alex Kellner | Third | 13 out |
| Saturday, September 29 |
| » Defeated Athletics (51-102), 5-1 | Municipal Stadium (7-3) | 85-68 | |
| » Starters: Dick Donovan vs Glenn Cox | Third | 12 out |
| Sunday, September 30 |
| » Lost to Athletics (52-102), 7-6 | Municipal Stadium (7-4) | 85-69 | |
| » Starters: Jim Derrington vs George Brunet | Third | 12 out |
| Monday, October 1 |
| Future White Sox Vance Law is born in Boise, ID. |
| Sunday, October 7 |
| Future White Sox Rudy Law is born in Waco, TX. |
| Thursday, November 1 |
| Future White Sox Gary Redus is born in Athens, AL. |
Game information provided by Retrosheet (www.retrosheet.org) |