| Saturday, January 28 |
| Former Senator Barry McCormick dies in Cincinnati, OH at the age of 82. |
| Wednesday, February 8 |
| Former Senator Long Tom Hughes dies in Chicago, IL at the age of 78. |
| Wednesday, April 4 |
| Former Senator Dolly Gray dies in Yuba City, CA at the age of 78. |
| Tuesday, April 17 |
| » Lost to Yankees (1-0), 10-4 | Griffith Stadium (0-1) | 0-1 | |
| » Starters: Don Larsen vs Camilo Pascual | Second | 1 out |
| » Major-league debuts: Whitey Herzog (Senators) Jerry Lumpe (Yankees) |
| Wednesday, April 18 |
| » Lost to Yankees (2-0), 9-5 | Griffith Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Johnny Kucks vs Bob Wiesler | Fourth | 2 out |
| » Major-league debuts: Hal Griggs and Herb Plews (Senators) |
| Thursday, April 19 |
| » Defeated Yankees (2-1), 7-3 | Griffith Stadium (1-2) | 1-2 | |
| » Starters: Mickey McDermott vs Chuck Stobbs | Fourth | 2 out |
| » Major-league debuts: Lou Skizas (Yankees) |
| Friday, April 20 |
| » Lost to Orioles (1-3), 3-2 | Memorial Stadium (0-1) | 1-3 | |
| » Starters: Dick Brodowski vs Jim Wilson | Fifth | 2½ out |
| Saturday, April 21 |
| » Defeated Orioles (1-4), 8-4 | Memorial Stadium (1-1) | 2-3 | |
| » Starters: Dean Stone vs Bill Wight | Fourth | 2 out |
| Sunday, April 22 |
| » Lost to Orioles (2-4), 7-3 | Memorial Stadium (1-2) | 2-4 | |
| » Starters: Bob Wiesler vs Fred Besana | Fifth | 2½ out |
| » Defeated Orioles (2-5), 4-1 | Memorial Stadium (2-2) | 3-4 | |
| » Starters: Camilo Pascual vs Ray Moore | Fifth | 2½ out |
| Tuesday, April 24 |
| » Lost to Yankees (6-1), 4-1 | Yankee Stadium (0-1) | 3-5 | |
| » Starters: Chuck Stobbs vs Johnny Kucks | Fifth | 3½ out |
| Wednesday, April 25 |
| » Defeated Red Sox (3-4), 4-1 | Fenway Park (1-0) | 4-5 | |
| » Starters: Pedro Ramos vs Bob Porterfield | Third | 3½ out |
| Thursday, April 26 |
| Former Senator Cliff Blankenship dies in Oakland, CA at the age of 77. |
| Friday, April 27 |
| » Defeated Orioles (3-7), 8-5 | Griffith Stadium (2-2) | 5-5 | Won 2 |
| » Starters: Fred Besana vs Dean Stone | Fourth | 2 out |
| Saturday, April 28 |
| » Defeated Orioles (3-8), 5-3 | Griffith Stadium (3-2) | 6-5 | Won 3 |
| » Starters: Bill Wight vs Camilo Pascual | Fourth | 2½ out |
| Sunday, April 29 |
| » Lost to Orioles (4-8), 8-6 | Griffith Stadium (3-3) | 6-6 | |
| » Starters: Ray Moore vs Chuck Stobbs | Fourth | 3½ out |
| » Defeated Orioles (4-9), 5-4 | Griffith Stadium (4-3) | 7-6 | |
| » Starters: Jim Wilson vs Bob Wiesler | Fourth | 3½ out |
| Tuesday, May 1 |
| » Lost to Indians (7-5), 3-2 | Griffith Stadium (4-4) | 7-7 | |
| » Starters: Early Wynn vs Pedro Ramos | Fourth | 3 out |
| Thursday, May 3 |
| » Defeated White Sox (5-3), 7-4 | Griffith Stadium (5-4) | 8-7 | |
| » Starters: Billy Pierce vs Dean Stone | Fourth | 1½ out |
| Friday, May 4 |
| » Lost to White Sox (6-3), 5-2 | Griffith Stadium (5-5) | 8-8 | |
| » Starters: Dick Donovan vs Camilo Pascual | Fifth | 2½ out |
| Saturday, May 5 |
| » Defeated White Sox (6-4), 4-2 | Griffith Stadium (6-5) | 9-8 | |
| » Starters: Connie Johnson vs Chuck Stobbs | Fourth | 2½ out |
| Sunday, May 6 |
| » Lost to Athletics (6-9), 10-7 | Griffith Stadium (6-6) | 9-9 | |
| » Starters: Troy Herriage vs Pedro Ramos | Fifth | 4½ out |
| » Lost to Athletics (7-9), 13-3 | Griffith Stadium (6-7) | 9-10 | Lost 2 |
| » Starters: Art Ditmar vs Dick Brodowski | Fifth | 4½ out |
| Tuesday, May 8 |
| » Lost to Tigers (7-12), 14-6 | Griffith Stadium (6-8) | 9-11 | Lost 3 |
| » Starters: Duke Maas vs Dean Stone | Sixth | 5½ out |
| Wednesday, May 9 |
| » Lost to Tigers (8-12), 7-3 | Griffith Stadium (6-9) | 9-12 | Lost 4 |
| » Starters: Paul Foytack vs Camilo Pascual | Seventh | 5½ out |
| Friday, May 11 |
| » Defeated Red Sox (10-9), 4-3 | Griffith Stadium (7-9) | 10-12 | |
| » Starters: Ike Delock vs Chuck Stobbs | Fifth | 5 out |
| Saturday, May 12 |
| » Defeated Red Sox (10-10), 12-9 | Griffith Stadium (8-9) | 11-12 | Won 2 |
| » Starters: Tom Brewer vs Pedro Ramos | Fifth | 4 out |
| Sunday, May 13 |
| » Lost to Red Sox (11-10), 5-3 | Griffith Stadium (8-10) | 11-13 | |
| » Starters: Frank Sullivan vs Camilo Pascual | Sixth | 4½ out |
| Tuesday, May 15 |
| » Lost to White Sox (11-8), 5-1 | Comiskey Park I (0-1) | 11-14 | Lost 2 |
| » Starters: Chuck Stobbs vs Bob Keegan | Sixth | 4½ out |
| Wednesday, May 16 |
| » Lost to White Sox (12-8), 3-1 | Comiskey Park I (0-2) | 11-15 | Lost 3 |
| » Starters: Hal Griggs vs Dick Donovan | Sixth | 5½ out |
| Friday, May 18 |
| » Defeated Indians (15-11), 5-4 | Cleveland Stadium (1-0) | 12-15 | |
| » Starters: Dean Stone vs Early Wynn | Sixth | 6 out |
| Saturday, May 19 |
| » Lost to Indians (16-11), 5-1 | Cleveland Stadium (1-1) | 12-16 | |
| » Starters: Camilo Pascual vs Herb Score | Sixth | 7 out |
| Sunday, May 20 |
| » Lost to Tigers (11-17), 4-2 | Tiger Stadium (0-1) | 12-17 | Lost 2 |
| » Starters: Chuck Stobbs vs Paul Foytack | Seventh | 8½ out |
| » Lost to Tigers (12-17), 7-1 | Tiger Stadium (0-2) | 12-18 | Lost 3 |
| » Starters: Hal Griggs vs Virgil Trucks | Seventh | 8½ out |
| Tuesday, May 22 |
| » Lost to Athletics (11-19), 6-1 | Municipal Stadium (0-1) | 12-19 | Lost 4 |
| » Starters: Bunky Stewart vs Troy Herriage | Seventh | 9 out |
| Wednesday, May 23 |
| » Lost to Athletics (12-19), 7-6 | Municipal Stadium (0-2) | 12-20 | Lost 5 |
| » Starters: Dean Stone vs Art Ditmar | Eighth | 10 out |
| Friday, May 25 |
| » Defeated Red Sox (17-14), 10-5 | Fenway Park (2-0) | 13-20 | |
| » Starters: Pedro Ramos vs George Susce | Seventh | 10½ out |
| Saturday, May 26 |
| » Defeated Red Sox (17-15), 4-1 | Fenway Park (3-0) | 14-20 | Won 2 |
| » Starters: Chuck Stobbs vs Ike Delock | Sixth | 9½ out |
| Former Senator Al Simmons dies in Milwaukee, WI at the age of 55. |
| Sunday, May 27 |
| » Lost to Red Sox (18-15), 9-7 | Fenway Park (3-1) | 14-21 | |
| » Starters: Tex Clevenger vs Tom Brewer | Sixth | 9½ out |
| » Defeated Red Sox (18-16), 11-10 | Fenway Park (4-1) | 15-21 | |
| » Starters: Camilo Pascual vs Bob Porterfield | Sixth | 9½ out |
| Monday, May 28 |
| » Lost to Orioles (17-19), 6-5 | Memorial Stadium (2-3) | 15-22 | |
| » Starters: Bob Wiesler vs Connie Johnson | Eighth | 10½ out |
| Tuesday, May 29 |
| » Defeated Orioles (17-20), 6-5 | Memorial Stadium (3-3) | 16-22 | |
| » Starters: Dean Stone vs Erv Palica | Seventh | 9½ out |
| Wednesday, May 30 |
| » Lost to Yankees (27-13), 4-3 | Yankee Stadium (0-2) | 16-23 | |
| » Starters: Pedro Ramos vs Johnny Kucks | Seventh | 11½ out |
| » Lost to Yankees (28-13), 12-5 | Yankee Stadium (0-3) | 16-24 | Lost 2 |
| » Starters: Camilo Pascual vs Bob Turley | Seventh | 11½ out |
| Thursday, May 31 |
| » Lost to Yankees (29-13), 9-6 | Yankee Stadium (0-4) | 16-25 | Lost 3 |
| » Starters: Chuck Stobbs vs Bob Grim | Seventh | 12½ out |
| Friday, June 1 |
| » Defeated Indians (20-18), 5-3 | Griffith Stadium (9-10) | 17-25 | |
| » Starters: Bob Lemon vs Bob Wiesler | Seventh | 11½ out |
| Saturday, June 2 |
| » Lost to Indians (21-18), 15-0 | Griffith Stadium (9-11) | 17-26 | |
| » Starters: Herb Score vs Dean Stone | Seventh | 12 out |
| Sunday, June 3 |
| » Lost to Indians (22-18), 8-4 | Griffith Stadium (9-12) | 17-27 | Lost 2 |
| » Starters: Early Wynn vs Camilo Pascual | Seventh | 11 out |
| » Defeated Indians (22-19), 7-1 | Griffith Stadium (10-12) | 18-27 | |
| » Starters: Don Mossi vs Hal Griggs | Seventh | 11 out |
| Monday, June 4 |
| » Lost to Indians (23-19), 7-0 | Griffith Stadium (10-13) | 18-28 | |
| » Starters: Mike Garcia vs Pedro Ramos | Seventh | 11½ out |
| Tuesday, June 5 |
| » Defeated White Sox (21-17), 3-1 | Griffith Stadium (11-13) | 19-28 | |
| » Starters: Jack Harshman vs Chuck Stobbs | Eighth | 10½ out |
| Wednesday, June 6 |
| » Defeated White Sox (21-18), 12-7 | Griffith Stadium (12-13) | 20-28 | Won 2 |
| » Starters: Gerry Staley vs Bob Wiesler | Sixth | 10½ out |
| Thursday, June 7 |
| » Lost to White Sox (22-18), 7-5 | Griffith Stadium (12-14) | 20-29 | |
| » Starters: Dick Donovan vs Dean Stone | Seventh | 11½ out |
| Friday, June 8 |
| » Lost to Tigers (23-23), 7-0 | Griffith Stadium (12-15) | 20-30 | Lost 2 |
| » Starters: Billy Hoeft vs Camilo Pascual | Seventh | 11½ out |
| Saturday, June 9 |
| » Lost to Tigers (24-23), 5-3 | Griffith Stadium (12-16) | 20-31 | Lost 3 |
| » Starters: Steve Gromek vs Hal Griggs | Sixth | 11½ out |
| Sunday, June 10 |
| » Defeated Tigers (24-24), 6-5 | Griffith Stadium (13-16) | 21-31 | |
| » Starters: Virgil Trucks vs Chuck Stobbs | Seventh | 11 out |
| » Defeated Tigers (24-25), 12-9 | Griffith Stadium (14-16) | 22-31 | Won 2 |
| » Starters: Paul Foytack vs Bob Wiesler | Seventh | 11 out |
| Monday, June 11 |
| » Defeated Athletics (19-31), 4-3 | Griffith Stadium (15-16) | 23-31 | Won 3 |
| » Starters: Lou Kretlow vs Connie Grob | Seventh | 11 out |
| » Lost to Athletics (20-31), 6-3 | Griffith Stadium (15-17) | 23-32 | |
| » Starters: Alex Kellner vs Dean Stone | Seventh | 11 out |
| Tuesday, June 12 |
| » Lost to Athletics (21-31), 9-3 | Griffith Stadium (15-18) | 23-33 | Lost 2 |
| » Starters: Jose Santiago vs Bunky Stewart | Seventh | 12 out |
| Wednesday, June 13 |
| » Lost to Athletics (22-31), 13-4 | Griffith Stadium (15-19) | 23-34 | Lost 3 |
| » Starters: Art Ditmar vs Pedro Ramos | Eighth | 12 out |
| Friday, June 15 |
| » Lost to White Sox (26-21), 7-2 | Comiskey Park I (0-3) | 23-35 | Lost 4 |
| » Starters: Bob Wiesler vs Billy Pierce | Seventh | 13½ out |
| Saturday, June 16 |
| » Lost to White Sox (27-21), 7-0 | Comiskey Park I (0-4) | 23-36 | Lost 5 |
| » Starters: Hal Griggs vs Jack Harshman | Seventh | 14½ out |
| Sunday, June 17 |
| » Lost to White Sox (28-21), 20-2 | Comiskey Park I (0-5) | 23-37 | Lost 6 |
| » Starters: Bunky Stewart vs Dick Donovan | Eighth | 15 out |
| » Defeated White Sox (28-22), 10-4 | Comiskey Park I (1-5) | 24-37 | |
| » Starters: Chuck Stobbs vs Bob Keegan | Eighth | 15 out |
| Monday, June 18 |
| » Lost to Athletics (23-34), 4-3 | Municipal Stadium (0-3) | 24-38 | |
| » Starters: Hal Griggs vs Alex Kellner | Eighth | 16 out |
| Tuesday, June 19 |
| » Defeated Athletics (23-35), 10-5 | Municipal Stadium (1-3) | 25-38 | |
| » Starters: Bunky Stewart vs Jose Santiago | Seventh | 16 out |
| Wednesday, June 20 |
| » Defeated Athletics (23-36), 5-4 | Municipal Stadium (2-3) | 26-38 | Won 2 |
| » Starters: Bob Wiesler vs Troy Herriage | Seventh | 16 out |
| Thursday, June 21 |
| » Lost to Athletics (24-36), 15-6 | Municipal Stadium (2-4) | 26-39 | |
| » Starters: Dean Stone vs Jose Santiago | Eighth | 16½ out |
| Friday, June 22 |
| » Lost to Indians (32-27), 4-0 | Cleveland Stadium (1-2) | 26-40 | Lost 2 |
| » Starters: Chuck Stobbs vs Mike Garcia | Seventh | 16½ out |
| Saturday, June 23 |
| » Lost to Indians (33-27), 9-8 | Cleveland Stadium (1-3) | 26-41 | Lost 3 |
| » Starters: Hal Griggs vs Art Houtteman | Seventh | 16½ out |
| Sunday, June 24 |
| » Lost to Indians (34-27), 7-2 | Cleveland Stadium (1-4) | 26-42 | Lost 4 |
| » Starters: Bob Wiesler vs Bob Lemon | Eighth | 16 out |
| Monday, June 25 |
| » Defeated Tigers (27-35), 5-3 | Tiger Stadium (1-2) | 27-42 | |
| » Starters: Camilo Pascual vs Billy Hoeft | Eighth | 16 out |
| Tuesday, June 26 |
| » Tied Tigers, 2-2 | Tiger Stadium (1-2) | 27-42 | |
| » Starters: Bunky Stewart vs Paul Foytack | Seventh | 16½ out |
| Wednesday, June 27 |
| » Defeated Tigers (27-36), 3-1 | Tiger Stadium (2-2) | 28-42 | Won 2 |
| » Starters: Bob Wiesler vs Frank Lary | Seventh | 16½ out |
| Friday, June 29 |
| » Lost to Yankees (44-24), 3-1 | Yankee Stadium (0-5) | 28-43 | |
| » Starters: Pedro Ramos vs Bob Grim | Seventh | 17½ out |
| Saturday, June 30 |
| » Defeated Yankees (44-25), 5-1 | Yankee Stadium (1-5) | 29-43 | |
| » Starters: Chuck Stobbs vs Johnny Kucks | Seventh | 16½ out |
| Sunday, July 1 |
| » Lost to Yankees (45-25), 3-2 | Yankee Stadium (1-6) | 29-44 | |
| » Starters: Camilo Pascual vs Whitey Ford | Seventh | 18½ out |
| » Lost to Yankees (46-25), 8-6 | Yankee Stadium (1-7) | 29-45 | Lost 2 |
| » Starters: Bunky Stewart vs Tommy Byrne | Seventh | 18½ out |
| Monday, July 2 |
| » Lost to Red Sox (36-32), 3-2 | Griffith Stadium (15-20) | 29-46 | Lost 3 |
| » Starters: Frank Sullivan vs Bob Wiesler | Seventh | 19 out |
| Tuesday, July 3 |
| » Defeated Red Sox (36-33), 6-5 | Griffith Stadium (16-20) | 30-46 | |
| » Starters: Dave Sisler vs Dean Stone | Seventh | 19 out |
| Wednesday, July 4 |
| » Defeated Orioles (32-40), 10-8 | Griffith Stadium (17-20) | 31-46 | Won 2 |
| » Starters: Hal Brown vs Chuck Stobbs | Seventh | 19 out |
| » Lost to Orioles (33-40), 7-4 | Griffith Stadium (17-21) | 31-47 | |
| » Starters: Connie Johnson vs Hal Griggs | Seventh | 19 out |
| Friday, July 6 |
| » Lost to Yankees (50-26), 8-4 | Griffith Stadium (17-22) | 31-48 | Lost 2 |
| » Starters: Bob Turley vs Bob Wiesler | Seventh | 20½ out |
| Saturday, July 7 |
| » Lost to Yankees (51-26), 8-3 | Griffith Stadium (17-23) | 31-49 | Lost 3 |
| » Starters: Mickey McDermott vs Camilo Pascual | Seventh | 21½ out |
| Sunday, July 8 |
| » Lost to Yankees (52-26), 8-2 | Griffith Stadium (17-24) | 31-50 | Lost 4 |
| » Starters: Tommy Byrne vs Chuck Stobbs | Seventh | 22½ out |
| Thursday, July 12 |
| » Lost to Tigers (35-42), 4-2 | Griffith Stadium (17-25) | 31-51 | Lost 5 |
| » Starters: Billy Hoeft vs Bob Wiesler | Seventh | 23½ out |
| Friday, July 13 |
| » Defeated Tigers (35-43), 12-11 | Griffith Stadium (18-25) | 32-51 | |
| » Starters: Paul Foytack vs Pedro Ramos | Seventh | 23½ out |
| Saturday, July 14 |
| » Lost to Tigers (36-43), 6-5 | Griffith Stadium (18-26) | 32-52 | |
| » Starters: Frank Lary vs Camilo Pascual | Seventh | 24½ out |
| Sunday, July 15 |
| » Lost to Athletics (30-50), 8-0 | Griffith Stadium (18-27) | 32-53 | Lost 2 |
| » Starters: Wally Burnette vs Chuck Stobbs | Seventh | 25½ out |
| » Defeated Athletics (30-51), 7-3 | Griffith Stadium (19-27) | 33-53 | |
| » Starters: Lou Kretlow vs Dean Stone | Seventh | 25½ out |
| » Major-league debuts: Wally Burnette (Athletics) |
| Wednesday, July 18 |
| » Defeated Indians (46-36), 7-5 | Griffith Stadium (20-27) | 34-53 | Won 2 |
| » Starters: Herb Score vs Bob Wiesler | Seventh | 25 out |
| » Lost to Indians (47-36), 11-1 | Griffith Stadium (20-28) | 34-54 | |
| » Starters: Early Wynn vs Camilo Pascual | Seventh | 25 out |
| Thursday, July 19 |
| » Defeated Indians (47-37), 5-4 | Griffith Stadium (21-28) | 35-54 | |
| » Starters: Mike Garcia vs Hal Griggs | Seventh | 25 out |
| Saturday, July 21 |
| » Defeated White Sox (44-39), 6-5 | Griffith Stadium (22-28) | 36-54 | Won 2 |
| » Starters: Dick Donovan vs Chuck Stobbs | Seventh | 25 out |
| Sunday, July 22 |
| » Lost to White Sox (45-39), 6-1 | Griffith Stadium (22-29) | 36-55 | |
| » Starters: Jack Harshman vs Bob Wiesler | Seventh | 25½ out |
| Tuesday, July 24 |
| » Lost to Indians (51-37), 11-0 | Cleveland Stadium (1-5) | 36-56 | Lost 2 |
| » Starters: Bunky Stewart vs Mike Garcia | Seventh | 25½ out |
| Wednesday, July 25 |
| » Lost to Indians (52-37), 11-3 | Cleveland Stadium (1-6) | 36-57 | Lost 3 |
| » Starters: Camilo Pascual vs Herb Score | Sixth | 26½ out |
| Thursday, July 26 |
| » Lost to Indians (53-37), 1-0 | Cleveland Stadium (1-7) | 36-58 | Lost 4 |
| » Starters: Chuck Stobbs vs Bob Lemon | Seventh | 27½ out |
| Friday, July 27 |
| » Lost to Tigers (42-51), 5-4 | Tiger Stadium (2-3) | 36-59 | Lost 5 |
| » Starters: Bob Wiesler vs Frank Lary | Sixth | 28½ out |
| Saturday, July 28 |
| » Defeated Tigers (42-52), 6-5 | Tiger Stadium (3-3) | 37-59 | |
| » Starters: Pedro Ramos vs Paul Foytack | Seventh | 28½ out |
| Sunday, July 29 |
| » Lost to Tigers (43-52), 6-0 | Tiger Stadium (3-4) | 37-60 | |
| » Starters: Bunky Stewart vs Billy Hoeft | Sixth | 29 out |
| » Defeated Tigers (43-53), 4-1 | Tiger Stadium (4-4) | 38-60 | |
| » Starters: Dean Stone vs Jim Bunning | Sixth | 29 out |
| Tuesday, July 31 |
| » Defeated White Sox (48-45), 4-3 | Comiskey Park I (2-5) | 39-60 | Won 2 |
| » Starters: Pedro Ramos vs Dick Donovan | Sixth | 28½ out |
| Wednesday, August 1 |
| » Defeated White Sox (48-46), 6-2 | Comiskey Park I (3-5) | 40-60 | Won 3 |
| » Starters: Chuck Stobbs vs Jim Wilson | Sixth | 27½ out |
| Thursday, August 2 |
| » Lost to White Sox (49-46), 5-4 | Comiskey Park I (3-6) | 40-61 | |
| » Starters: Bob Wiesler vs Bob Keegan | Sixth | 27½ out |
| Friday, August 3 |
| » Defeated Athletics (36-64), 2-1 | Municipal Stadium (3-4) | 41-61 | |
| » Starters: Camilo Pascual vs Art Ditmar | Seventh | 26½ out |
| Saturday, August 4 |
| » Defeated Athletics (36-65), 5-4 | Municipal Stadium (4-4) | 42-61 | Won 2 |
| » Starters: Pedro Ramos vs Wally Burnette | Seventh | 25½ out |
| Sunday, August 5 |
| » Defeated Athletics (36-66), 10-4 | Municipal Stadium (5-4) | 43-61 | Won 3 |
| » Starters: Chuck Stobbs vs Troy Herriage | Seventh | 24½ out |
| Wednesday, August 8 |
| » Lost to Yankees (69-37), 12-2 | Griffith Stadium (22-30) | 43-62 | |
| » Starters: Bob Turley vs Camilo Pascual | Seventh | 25½ out |
| Thursday, August 9 |
| » Lost to Yankees (70-37), 15-7 | Griffith Stadium (22-31) | 43-63 | Lost 2 |
| » Starters: Johnny Kucks vs Bunky Stewart | Seventh | 26½ out |
| Friday, August 10 |
| » Lost to Red Sox (62-45), 3-2 | Griffith Stadium (22-32) | 43-64 | Lost 3 |
| » Starters: Tom Brewer vs Chuck Stobbs | Seventh | 27½ out |
| Saturday, August 11 |
| » Defeated Red Sox (62-46), 6-1 | Griffith Stadium (23-32) | 44-64 | |
| » Starters: Dave Sisler vs Pedro Ramos | Seventh | 26½ out |
| Sunday, August 12 |
| » Defeated Red Sox (62-47), 8-2 | Griffith Stadium (24-32) | 45-64 | Won 2 |
| » Starters: Willard Nixon vs Dean Stone | Seventh | 27 out |
| Tuesday, August 14 |
| » Lost to Orioles (49-62), 3-0 | Memorial Stadium (3-4) | 45-65 | |
| » Starters: Chuck Stobbs vs Connie Johnson | Seventh | 28 out |
| Wednesday, August 15 |
| » Lost to Orioles (50-62), 3-2 | Memorial Stadium (3-5) | 45-66 | Lost 2 |
| » Starters: Camilo Pascual vs Mike Fornieles | Seventh | 29 out |
| Friday, August 17 |
| » Defeated Red Sox (63-50), 6-5 | Fenway Park (5-1) | 46-66 | |
| » Starters: Pedro Ramos vs Frank Sullivan | Seventh | 27½ out |
| Saturday, August 18 |
| » Defeated Red Sox (63-51), 9-7 | Fenway Park (6-1) | 47-66 | Won 2 |
| » Starters: Dean Stone vs George Susce | Seventh | 28 out |
| Sunday, August 19 |
| » Defeated Red Sox (63-52), 7-5 | Fenway Park (7-1) | 48-66 | Won 3 |
| » Starters: Chuck Stobbs vs Tom Brewer | Seventh | 26½ out |
| » Defeated Red Sox (63-53), 11-10 | Fenway Park (8-1) | 49-66 | Won 4 |
| » Starters: Camilo Pascual vs Mel Parnell | Seventh | 26½ out |
| Tuesday, August 21 |
| » Lost to Tigers (56-62), 8-3 | Griffith Stadium (24-33) | 49-67 | |
| » Starters: Steve Gromek vs Hal Griggs | Seventh | 26½ out |
| Wednesday, August 22 |
| » Lost to Tigers (57-62), 9-5 | Griffith Stadium (24-34) | 49-68 | Lost 2 |
| » Starters: Paul Foytack vs Dean Stone | Seventh | 27½ out |
| Thursday, August 23 |
| » Defeated Athletics (39-80), 5-3 | Griffith Stadium (25-34) | 50-68 | |
| » Starters: Jack Crimian vs Chuck Stobbs | Seventh | 26 out |
| Friday, August 24 |
| » Lost to Athletics (40-80), 8-4 | Griffith Stadium (25-35) | 50-69 | |
| » Starters: Lou Kretlow vs Pedro Ramos | Seventh | 27 out |
| Saturday, August 25 |
| » Defeated Athletics (40-81), 8-4 | Griffith Stadium (26-35) | 51-69 | |
| » Starters: Art Ditmar vs Camilo Pascual | Seventh | 26 out |
| Sunday, August 26 |
| » Lost to Indians (70-51), 4-1 | Griffith Stadium (26-36) | 51-70 | |
| » Starters: Early Wynn vs Dean Stone | Seventh | 26½ out |
| Monday, August 27 |
| » Lost to Indians (71-51), 5-2 | Griffith Stadium (26-37) | 51-71 | Lost 2 |
| » Starters: Bob Lemon vs Hal Griggs | Seventh | 27 out |
| Tuesday, August 28 |
| » Defeated White Sox (67-55), 6-2 | Griffith Stadium (27-37) | 52-71 | |
| » Starters: Bob Keegan vs Chuck Stobbs | Seventh | 27½ out |
| » Lost to White Sox (68-55), 5-3 | Griffith Stadium (27-38) | 52-72 | |
| » Starters: Jack Harshman vs Pedro Ramos | Seventh | 27½ out |
| Wednesday, August 29 |
| » Lost to White Sox (69-55), 9-7 | Griffith Stadium (27-39) | 52-73 | Lost 2 |
| » Starters: Jim Wilson vs Bob Wiesler | Seventh | 28½ out |
| Friday, August 31 |
| » Lost to Yankees (83-46), 6-4 | Griffith Stadium (27-40) | 52-74 | Lost 3 |
| » Starters: Whitey Ford vs Camilo Pascual | Seventh | 29½ out |
| Saturday, September 1 |
| » Defeated Yankees (83-47), 4-3 | Griffith Stadium (28-40) | 53-74 | |
| » Starters: Tom Sturdivant vs Chuck Stobbs | Seventh | 28½ out |
| Sunday, September 2 |
| » Defeated Yankees (83-48), 4-3 | Griffith Stadium (29-40) | 54-74 | Won 2 |
| » Starters: Bob Turley vs Dean Stone | Seventh | 27½ out |
| Monday, September 3 |
| » Lost to Red Sox (70-59), 7-5 | Griffith Stadium (29-41) | 54-75 | |
| » Starters: Mel Parnell vs Hal Griggs | Seventh | 29½ out |
| » Lost to Red Sox (71-59), 16-0 | Griffith Stadium (29-42) | 54-76 | Lost 2 |
| » Starters: Tom Brewer vs Bob Wiesler | Seventh | 29½ out |
| Tuesday, September 4 |
| » Lost to Red Sox (72-59), 7-6 | Griffith Stadium (29-43) | 54-77 | Lost 3 |
| » Starters: Dave Sisler vs Camilo Pascual | Seventh | 30 out |
| Wednesday, September 5 |
| » Defeated Orioles (58-73), 2-0 | Griffith Stadium (30-43) | 55-77 | |
| » Starters: Connie Johnson vs Chuck Stobbs | Seventh | 30 out |
| Thursday, September 6 |
| » Defeated Orioles (58-74), 7-5 | Griffith Stadium (31-43) | 56-77 | Won 2 |
| » Starters: Ray Moore vs Dean Stone | Seventh | 29½ out |
| Friday, September 7 |
| » Defeated Yankees (86-49), 6-5 | Yankee Stadium (2-7) | 57-77 | Won 3 |
| » Starters: Bob Chakales vs Johnny Kucks | Seventh | 28½ out |
| Saturday, September 8 |
| » Lost to Yankees (87-49), 16-2 | Yankee Stadium (2-8) | 57-78 | |
| » Starters: Camilo Pascual vs Tom Sturdivant | Sixth | 29½ out |
| Sunday, September 9 |
| » Lost to Yankees (88-49), 2-1 | Yankee Stadium (2-9) | 57-79 | Lost 2 |
| » Starters: Chuck Stobbs vs Whitey Ford | Sixth | 30½ out |
| Tuesday, September 11 |
| » Lost to Tigers (70-67), 12-0 | Tiger Stadium (4-5) | 57-80 | Lost 3 |
| » Starters: Dean Stone vs Frank Lary | Seventh | 31½ out |
| Wednesday, September 12 |
| » Lost to Tigers (71-67), 3-2 | Tiger Stadium (4-6) | 57-81 | Lost 4 |
| » Starters: Evelio Hernandez vs Billy Hoeft | Seventh | 31½ out |
| » Major-league debuts: Charlie Lau (Tigers) |
| Thursday, September 13 |
| » Lost to Tigers (72-67), 7-2 | Tiger Stadium (4-7) | 57-82 | Lost 5 |
| » Starters: Chuck Stobbs vs Paul Foytack | Seventh | 32½ out |
| Friday, September 14 |
| » Defeated Athletics (44-95), 4-1 | Municipal Stadium (6-4) | 58-82 | |
| » Starters: Ted Abernathy vs Walt Craddock | Seventh | 32½ out |
| Saturday, September 15 |
| » Lost to Athletics (45-95), 10-5 | Municipal Stadium (6-5) | 58-83 | |
| » Starters: Camilo Pascual vs Carl Duser | Seventh | 32½ out |
| Sunday, September 16 |
| » Lost to White Sox (79-62), 7-5 | Comiskey Park I (3-7) | 58-84 | Lost 2 |
| » Starters: Evelio Hernandez vs Jack Harshman | Seventh | 33½ out |
| » Lost to White Sox (80-62), 7-2 | Comiskey Park I (3-8) | 58-85 | Lost 3 |
| » Starters: Dick Brodowski vs Gerry Staley | Seventh | 33½ out |
| Tuesday, September 18 |
| » Lost to Indians (81-63), 1-0 | Cleveland Stadium (1-8) | 58-86 | Lost 4 |
| » Starters: Bob Wiesler vs Herb Score | Seventh | 35 out |
| » Lost to Indians (82-63), 6-0 | Cleveland Stadium (1-9) | 58-87 | Lost 5 |
| » Starters: Chuck Stobbs vs Mike Garcia | Seventh | 35 out |
| Wednesday, September 19 |
| » Lost to Indians (83-63), 6-0 | Cleveland Stadium (1-10) | 58-88 | Lost 6 |
| » Starters: Ted Abernathy vs Bob Lemon | Seventh | 35½ out |
| Friday, September 21 |
| » Lost to Orioles (63-83), 7-3 | Memorial Stadium (3-6) | 58-89 | Lost 7 |
| » Starters: Camilo Pascual vs Bill Wight | Seventh | 35½ out |
| Saturday, September 22 |
| » Lost to Orioles (64-83), 8-6 | Memorial Stadium (3-7) | 58-90 | Lost 8 |
| » Starters: Evelio Hernandez vs Ray Moore | Seventh | 36½ out |
| Former Senator Jesse Tannehill dies in Dayton, KY at the age of 83. |
| Sunday, September 23 |
| » Lost to Orioles (65-83), 6-0 | Memorial Stadium (3-8) | 58-91 | Lost 9 |
| » Starters: Chuck Stobbs vs Connie Johnson | Seventh | 37½ out |
| Tuesday, September 25 |
| » Lost to Red Sox (81-69), 10-4 | Fenway Park (8-2) | 58-92 | Lost 10 |
| » Starters: Pedro Ramos vs Dave Sisler | Seventh | 38 out |
| Wednesday, September 26 |
| » Lost to Red Sox (82-69), 8-4 | Fenway Park (8-3) | 58-93 | Lost 11 |
| » Starters: Ted Abernathy vs Frank Sullivan | Seventh | 38 out |
| Saturday, September 29 |
| » Defeated Orioles (67-85), 7-1 | Griffith Stadium (32-43) | 59-93 | |
| » Starters: Ron Moeller vs Evelio Hernandez | Seventh | 37½ out |
| Sunday, September 30 |
| » Lost to Orioles (68-85), 4-2 | Griffith Stadium (32-44) | 59-94 | |
| » Starters: Sandy Consuegra vs Chuck Stobbs | Seventh | 38 out |
| » Lost to Orioles (69-85), 6-3 | Griffith Stadium (32-45) | 59-95 | Lost 2 |
| » Starters: Don Ferrarese vs Ted Abernathy | Seventh | 38 out |
| Thursday, October 4 |
| Former Senator Jake Gettman dies in Denver, CO at the age of 80. |
| Saturday, October 13 |
| Former Senator George Dumont dies in Minneapolis, MN at the age of 61. |
Game information provided by Retrosheet (www.retrosheet.org) |
