| Thursday, February 2 |
| Future Pirate Manny Sarmiento is born in Cagua, Venezuela. |
| Saturday, March 10 |
| Former Pirate Solly Hofman dies in St.Louis, MO at the age of 74. |
| Saturday, March 17 |
| Future Pirate Rod Scurry is born in Sacramento, CA. |
| Tuesday, March 27 |
| Future Pirate Dave Hostetler is born in Pasadena, CA. |
| Tuesday, April 10 |
| Former Pirate Ginger Beaumont dies in Burlington, WI at the age of 80. |
| Tuesday, April 17 |
| » Lost to Giants (1-0), 4-3 | Polo Grounds V (0-1) | 0-1 | |
| » Starters: Bob Friend vs Johnny Antonelli | Second | 1 out |
| Wednesday, April 18 |
| » Lost to Giants (2-0), 5-4 | Polo Grounds V (0-2) | 0-2 | Lost 2 |
| » Starters: Dick Littlefield vs Ruben Gomez | Fourth | 2 out |
| » Major-league debuts: Jack McMahan (Pirates) |
| Thursday, April 19 |
| » Defeated Giants (2-1), 3-2 | Polo Grounds V (1-2) | 1-2 | |
| » Starters: Ron Kline vs Al Worthington | Fourth | 1½ out |
| Friday, April 20 |
| » Lost to Dodgers (2-1), 5-0 | Forbes Field (0-1) | 1-3 | |
| » Starters: Roger Craig vs Dick Hall | Fifth | 2½ out |
| Saturday, April 21 |
| » Defeated Dodgers (2-2), 3-1 | Forbes Field (1-1) | 2-3 | |
| » Starters: Ken Lehman vs Bob Friend | Fourth | 1½ out |
| » Major-league debuts: Bill Fischer (Dodgers) |
| Sunday, April 22 |
| » Lost to Dodgers (3-2), 4-1 | Forbes Field (1-2) | 2-4 | |
| » Starters: Don Newcombe vs Vern Law | Fourth | 2 out |
| Wednesday, April 25 |
| » Defeated Phillies (3-4), 6-5 | Shibe Park (1-0) | 3-4 | |
| » Starters: Bob Friend vs Jim Owens | Fifth | 2 out |
| » Major-league debuts: Angelo Lipetri (Phillies) |
| Friday, April 27 |
| » Lost to Dodgers (6-2), 7-2 | Ebbets Field (0-1) | 3-5 | |
| » Starters: Ron Kline vs Roger Craig | Sixth | 3 out |
| Saturday, April 28 |
| » Lost to Dodgers (7-2), 5-2 | Ebbets Field (0-2) | 3-6 | Lost 2 |
| » Starters: Dick Hall vs Don Newcombe | Sixth | 4 out |
| Sunday, April 29 |
| » Defeated Dodgers (7-3), 10-1 | Ebbets Field (1-2) | 4-6 | |
| » Starters: Bob Friend vs Don Drysdale | Fifth | 2½ out |
| » Defeated Dodgers (7-4), 11-3 | Ebbets Field (2-2) | 5-6 | Won 2 |
| » Starters: Vern Law vs Billy Loes | Fifth | 2½ out |
| Tuesday, May 1 |
| » Defeated Cardinals (6-4), 4-2 | Sportsman's Park III (1-0) | 6-6 | Won 3 |
| » Starters: Dick Littlefield vs Vinegar Bend Mizell | Fifth | 2 out |
| Wednesday, May 2 |
| » Lost to Cardinals (7-4), 10-9 | Sportsman's Park III (1-1) | 6-7 | |
| » Starters: Ron Kline vs Harvey Haddix | Fifth | 2 out |
| » Major-league debuts: Hal Smith (Cardinals) |
| Thursday, May 3 |
| » Defeated Reds (7-6), 5-1 | Crosley Field (1-0) | 7-7 | |
| » Starters: Bob Friend vs Joe Nuxhall | Fifth | 3 out |
| Friday, May 4 |
| » Lost to Reds (8-6), 4-3 | Crosley Field (1-1) | 7-8 | |
| » Starters: Dick Hall vs Art Fowler | Sixth | 3 out |
| Future Pirate Ken Oberkfell is born in Highland, IL. |
| Saturday, May 5 |
| » Lost to Reds (9-6), 7-6 | Crosley Field (1-2) | 7-9 | Lost 2 |
| » Starters: Vern Law vs Joe Nuxhall | Sixth | 3½ out |
| Sunday, May 6 |
| » Defeated Cubs (4-10), 2-1 | Wrigley Field (1-0) | 8-9 | |
| » Starters: Ron Kline vs Paul Minner | Fifth | 4 out |
| » Tied Cubs, 6-6 | Wrigley Field (1-0) | 8-9 | |
| » Starters: Bob Friend vs Sam Jones | Fifth | 4 out |
| Monday, May 7 |
| » Major-league debuts: Bill White (Giants) |
| Tuesday, May 8 |
| » Lost to Braves (8-3), 5-0 | County Stadium (0-1) | 8-10 | |
| » Starters: Bob Friend vs Warren Spahn | Fifth | 3½ out |
| Friday, May 11 |
| » Defeated Phillies (5-13), 6-5 | Forbes Field (2-2) | 9-10 | |
| » Starters: Ron Negray vs Vern Law | Fifth | 3½ out |
| Saturday, May 12 |
| » Defeated Phillies (5-14), 6-5 | Forbes Field (3-2) | 10-10 | Won 2 |
| » Starters: Robin Roberts vs Bob Friend | Fifth | 3½ out |
| Sunday, May 13 |
| » Defeated Phillies (5-15), 11-9 | Forbes Field (4-2) | 11-10 | Won 3 |
| » Starters: Harvey Haddix vs Ron Kline | Fifth | 3½ out |
| » Lost to Phillies (6-15), 7-2 | Forbes Field (4-3) | 11-11 | |
| » Starters: Saul Rogovin vs Dick Hall | Fifth | 3½ out |
| Wednesday, May 16 |
| » Defeated Reds (13-11), 9-2 | Forbes Field (5-3) | 12-11 | |
| » Starters: Joe Nuxhall vs Bob Friend | Fifth | 3 out |
| Thursday, May 17 |
| » Lost to Cubs (6-15), 4-1 | Forbes Field (5-4) | 12-12 | |
| » Starters: Russ Meyer vs Ron Kline | Fifth | 3 out |
| Friday, May 18 |
| » Lost to Cubs (7-15), 3-2 | Forbes Field (5-5) | 12-13 | Lost 2 |
| » Starters: Paul Minner vs Vern Law | Fifth | 3½ out |
| Saturday, May 19 |
| » Defeated Cubs (7-16), 7-4 | Forbes Field (6-5) | 13-13 | |
| » Starters: Sam Jones vs Red Munger | Fifth | 3½ out |
| Sunday, May 20 |
| » Defeated Braves (13-7), 6-3 | Forbes Field (7-5) | 14-13 | Won 2 |
| » Starters: Ray Crone vs Bob Friend | Fifth | 3½ out |
| » Defeated Braves (13-8), 5-0 | Forbes Field (8-5) | 15-13 | Won 3 |
| » Starters: Warren Spahn vs Ron Kline | Fifth | 3½ out |
| Tuesday, May 22 |
| » Lost to Cardinals (19-12), 6-3 | Forbes Field (8-6) | 15-14 | |
| » Starters: Herm Wehmeier vs Vern Law | Fifth | 3½ out |
| Wednesday, May 23 |
| » Defeated Cardinals (19-13), 6-0 | Forbes Field (9-6) | 16-14 | |
| » Starters: Willard Schmidt vs Bob Friend | Fifth | 4 out |
| Friday, May 25 |
| » Defeated Phillies (11-20), 8-5 | Shibe Park (2-0) | 17-14 | Won 2 |
| » Starters: Ron Kline vs Curt Simmons | Fourth | 4 out |
| » Major-league debuts: Mack Burk (Phillies) |
| Saturday, May 26 |
| » Defeated Phillies (11-21), 6-2 | Shibe Park (3-0) | 18-14 | Won 3 |
| » Starters: Vern Law vs Stu Miller | Fourth | 4 out |
| Monday, May 28 |
| » Defeated Dodgers (17-15), 3-2 | Forbes Field (10-6) | 19-14 | Won 4 |
| » Starters: Carl Erskine vs Bob Friend | Third | 3½ out |
| Tuesday, May 29 |
| » Lost to Dodgers (18-15), 10-1 | Forbes Field (10-7) | 19-15 | |
| » Starters: Don Newcombe vs Ron Kline | Third | 4 out |
| Wednesday, May 30 |
| » Defeated Giants (14-20), 5-4 | Forbes Field (11-7) | 20-15 | |
| » Starters: Johnny Antonelli vs Vern Law | Fourth | 4 out |
| » Lost to Giants (15-20), 5-3 | Forbes Field (11-8) | 20-16 | |
| » Starters: Don Liddle vs Laurin Pepper | Fourth | 4 out |
| Thursday, May 31 |
| » Defeated Giants (15-21), 3-0 | Forbes Field (12-8) | 21-16 | |
| » Starters: Jim Hearn vs Ron Kline | Third | 4 out |
| Friday, June 1 |
| » Defeated Braves (19-11), 4-1 | County Stadium (1-1) | 22-16 | Won 2 |
| » Starters: Bob Friend vs Warren Spahn | Second | 4 out |
| Saturday, June 2 |
| » Defeated Braves (19-12), 4-2 | County Stadium (2-1) | 23-16 | Won 3 |
| » Starters: Red Munger vs Gene Conley | Second | 4 out |
| Sunday, June 3 |
| » Defeated Braves (19-13), 3-1 | County Stadium (3-1) | 24-16 | Won 4 |
| » Starters: Roy Face vs Ray Crone | Second | 4 out |
| » Lost to Braves (20-13), 4-3 | County Stadium (3-2) | 24-17 | |
| » Starters: Vern Law vs Bob Buhl | Second | 4 out |
| Tuesday, June 5 |
| » Lost to Cubs (14-25), 7-3 | Wrigley Field (1-1) | 24-18 | Lost 2 |
| » Starters: Bob Friend vs Warren Hacker | Third | ½ out |
| Wednesday, June 6 |
| » Defeated Cubs (14-26), 8-2 | Wrigley Field (2-1) | 25-18 | |
| » Starters: Ron Kline vs Paul Minner | Third | ½ out |
| Thursday, June 7 |
| » Lost to Cubs (15-26), 5-2 | Wrigley Field (2-2) | 25-19 | |
| » Starters: Roy Face vs Bob Rush | Third | 1½ out |
| Friday, June 8 |
| » Defeated Cardinals (27-20), 2-0 | Sportsman's Park III (2-1) | 26-19 | |
| » Starters: Bob Friend vs Murry Dickson | Second | 1½ out |
| Saturday, June 9 |
| » Lost to Cardinals (28-20), 8-3 | Sportsman's Park III (2-2) | 26-20 | |
| » Starters: Vern Law vs Vinegar Bend Mizell | Third | 1½ out |
| Sunday, June 10 |
| » Defeated Cardinals (28-21), 11-3 | Sportsman's Park III (3-2) | 27-20 | |
| » Starters: Luis Arroyo vs Willard Schmidt | Third | 1 out |
| » Lost to Cardinals (29-21), 3-0 | Sportsman's Park III (3-3) | 27-21 | |
| » Starters: Ron Kline vs Herm Wehmeier | Third | 1 out |
| Tuesday, June 12 |
| » Defeated Reds (28-21), 4-3 | Crosley Field (2-2) | 28-21 | |
| » Starters: Bob Friend vs Joe Nuxhall | First | -- |
| Thursday, June 14 |
| » Major-league debuts: Ed Bressoud (Giants) |
| Friday, June 15 |
| » Defeated Cardinals (29-24), 12-1 | Forbes Field (13-8) | 29-21 | Won 2 |
| » Starters: Vinegar Bend Mizell vs Ron Kline | First | -- |
| Future Pirate Lance Parrish is born in Clairton, PA. |
| Saturday, June 16 |
| » Defeated Cardinals (29-25), 2-0 | Forbes Field (14-8) | 30-21 | Won 3 |
| » Starters: Herm Wehmeier vs Bob Friend | First | -- |
| Sunday, June 17 |
| » Lost to Cardinals (30-25), 3-1 | Forbes Field (14-9) | 30-22 | |
| » Starters: Tom Poholsky vs Vern Law | First | -- |
| » Lost to Cardinals (31-25), 8-3 | Forbes Field (14-10) | 30-23 | Lost 2 |
| » Starters: Willard Schmidt vs Luis Arroyo | First | -- |
| Monday, June 18 |
| » Lost to Braves (27-22), 3-2 | Forbes Field (14-11) | 30-24 | Lost 3 |
| » Starters: Warren Spahn vs Ron Kline | Third | 1 out |
| Tuesday, June 19 |
| » Lost to Braves (28-22), 5-3 | Forbes Field (14-12) | 30-25 | Lost 4 |
| » Starters: Lew Burdette vs Bob Friend | Fifth | 1 out |
| Wednesday, June 20 |
| » Lost to Braves (29-22), 7-3 | Forbes Field (14-13) | 30-26 | Lost 5 |
| » Starters: Gene Conley vs Vern Law | Fifth | 2½ out |
| Thursday, June 21 |
| » Lost to Braves (30-22), 7-2 | Forbes Field (14-14) | 30-27 | Lost 6 |
| » Starters: Bob Buhl vs Ron Kline | Fifth | 2½ out |
| » Major-league debuts: Felix Mantilla (Braves) |
| Saturday, June 23 |
| » Lost to Cubs (23-31), 9-5 | Forbes Field (14-15) | 30-28 | Lost 7 |
| » Starters: Warren Hacker vs Bob Friend | Fifth | 4 out |
| Sunday, June 24 |
| » Lost to Cubs (24-31), 5-3 | Forbes Field (14-16) | 30-29 | Lost 8 |
| » Starters: Bob Rush vs Vern Law | Fifth | 5 out |
| » Defeated Cubs (24-32), 1-0 | Forbes Field (15-16) | 31-29 | |
| » Starters: Sam Jones vs Laurin Pepper | Fifth | 5 out |
| Monday, June 25 |
| » Lost to Reds (35-26), 2-1 | Forbes Field (15-17) | 31-30 | |
| » Starters: Art Fowler vs Ron Kline | Fifth | 6 out |
| Wednesday, June 27 |
| » Lost to Reds (36-26), 10-2 | Forbes Field (15-18) | 31-31 | Lost 2 |
| » Starters: Brooks Lawrence vs Bob Friend | Fifth | 5½ out |
| Thursday, June 28 |
| » Lost to Reds (37-26), 4-3 | Forbes Field (15-19) | 31-32 | Lost 3 |
| » Starters: Johnny Klippstein vs Red Munger | Fifth | 6 out |
| Friday, June 29 |
| » Defeated Giants (25-38), 6-3 | Forbes Field (16-19) | 32-32 | |
| » Starters: Jim Hearn vs Vern Law | Fifth | 5 out |
| Saturday, June 30 |
| » Lost to Giants (26-38), 6-4 | Forbes Field (16-20) | 32-33 | |
| » Starters: Ruben Gomez vs Ron Kline | Fourth | 6 out |
| Sunday, July 1 |
| » Lost to Giants (27-38), 3-2 | Forbes Field (16-21) | 32-34 | Lost 2 |
| » Starters: Johnny Antonelli vs Bob Friend | Fifth | 7 out |
| » Lost to Giants (28-38), 7-6 | Forbes Field (16-22) | 32-35 | Lost 3 |
| » Starters: Dick Littlefield vs Laurin Pepper | Fifth | 7 out |
| Tuesday, July 3 |
| » Defeated Phillies (29-40), 6-5 | Forbes Field (17-22) | 33-35 | |
| » Starters: Curt Simmons vs Vern Law | Fifth | 6½ out |
| Wednesday, July 4 |
| » Lost to Phillies (30-40), 4-2 | Forbes Field (17-23) | 33-36 | |
| » Starters: Harvey Haddix vs Ron Kline | Fifth | 6½ out |
| » Defeated Phillies (30-41), 8-4 | Forbes Field (18-23) | 34-36 | |
| » Starters: Stu Miller vs Red Munger | Fifth | 6½ out |
| Saturday, July 7 |
| » Lost to Giants (30-40), 3-2 | Polo Grounds V (1-3) | 34-37 | |
| » Starters: Bob Friend vs Johnny Antonelli | Fifth | 8 out |
| » Major-league debuts: Bill Mazeroski (Pirates) |
| Sunday, July 8 |
| » Lost to Giants (31-40), 11-1 | Polo Grounds V (1-4) | 34-38 | Lost 2 |
| » Starters: Vern Law vs Ruben Gomez | Fifth | 8½ out |
| » Defeated Giants (31-41), 5-2 | Polo Grounds V (2-4) | 35-38 | |
| » Starters: Ron Kline vs Al Worthington | Fifth | 8½ out |
| Thursday, July 12 |
| » Defeated Cubs (31-41), 2-1 | Wrigley Field (3-2) | 36-38 | Won 2 |
| » Starters: Ron Kline vs Don Kaiser | Fifth | 7 out |
| » Defeated Cubs (31-42), 5-4 | Wrigley Field (4-2) | 37-38 | Won 3 |
| » Starters: Cholly Naranjo vs Sam Jones | Fifth | 7 out |
| Friday, July 13 |
| » Lost to Cubs (32-42), 7-6 | Wrigley Field (4-3) | 37-39 | |
| » Starters: Bob Friend vs Warren Hacker | Fifth | 8 out |
| Saturday, July 14 |
| » Lost to Cubs (33-42), 6-2 | Wrigley Field (4-4) | 37-40 | Lost 2 |
| » Starters: Vern Law vs Bob Rush | Fifth | 9½ out |
| » Lost to Cubs (34-42), 6-5 | Wrigley Field (4-5) | 37-41 | Lost 3 |
| » Starters: Red Munger vs Jim Davis | Fifth | 9½ out |
| Sunday, July 15 |
| » Lost to Braves (46-30), 3-2 | County Stadium (3-3) | 37-42 | Lost 4 |
| » Starters: Laurin Pepper vs Warren Spahn | Fifth | 11½ out |
| » Lost to Braves (47-30), 4-1 | County Stadium (3-4) | 37-43 | Lost 5 |
| » Starters: Cholly Naranjo vs Bob Trowbridge | Fifth | 11½ out |
| Monday, July 16 |
| » Lost to Braves (48-30), 2-1 | County Stadium (3-5) | 37-44 | Lost 6 |
| » Starters: Ron Kline vs Bob Buhl | Fifth | 12½ out |
| Tuesday, July 17 |
| » Defeated Cardinals (41-42), 4-2 | Sportsman's Park III (4-3) | 38-44 | |
| » Starters: Bob Friend vs Herm Wehmeier | Fifth | 11½ out |
| Wednesday, July 18 |
| » Tied Cardinals, 1-1 | Sportsman's Park III (4-3) | 38-44 | |
| » Starters: Red Munger vs Vinegar Bend Mizell | Sixth | 12 out |
| Friday, July 20 |
| » Lost to Reds (50-34), 6-4 | Crosley Field (2-3) | 38-45 | |
| » Starters: Ron Kline vs Don Gross | Fifth | 13½ out |
| Saturday, July 21 |
| » Defeated Reds (50-35), 4-3 | Crosley Field (3-3) | 39-45 | |
| » Starters: Bob Friend vs Brooks Lawrence | Fifth | 12½ out |
| Sunday, July 22 |
| » Defeated Reds (50-36), 8-6 | Crosley Field (4-3) | 40-45 | Won 2 |
| » Starters: Vern Law vs Art Fowler | Fifth | 13½ out |
| » Lost to Reds (51-36), 9-2 | Crosley Field (4-4) | 40-46 | |
| » Starters: Cholly Naranjo vs Joe Nuxhall | Fifth | 13½ out |
| Monday, July 23 |
| » Lost to Reds (52-36), 4-3 | Crosley Field (4-5) | 40-47 | Lost 2 |
| » Starters: Laurin Pepper vs Art Fowler | Fifth | 14 out |
| Tuesday, July 24 |
| » Defeated Cubs (39-47), 6-2 | Forbes Field (19-23) | 41-47 | |
| » Starters: Bob Rush vs Ron Kline | Fifth | 14 out |
| Wednesday, July 25 |
| » Defeated Cubs (39-48), 9-8 | Forbes Field (20-23) | 42-47 | Won 2 |
| » Starters: Warren Hacker vs Bob Friend | Fifth | 14 out |
| Thursday, July 26 |
| » Defeated Cubs (39-49), 4-0 | Forbes Field (21-23) | 43-47 | Won 3 |
| » Starters: Sam Jones vs Fred Waters | Fifth | 14 out |
| Friday, July 27 |
| » Lost to Reds (53-39), 3-2 | Forbes Field (21-24) | 43-48 | |
| » Starters: Art Fowler vs Red Munger | Fifth | 14 out |
| Saturday, July 28 |
| » Lost to Reds (54-39), 8-3 | Forbes Field (21-25) | 43-49 | Lost 2 |
| » Starters: Johnny Klippstein vs Ron Kline | Fifth | 14½ out |
| Sunday, July 29 |
| » Lost to Reds (55-39), 6-1 | Forbes Field (21-26) | 43-50 | Lost 3 |
| » Starters: Brooks Lawrence vs Bob Friend | Fifth | 15 out |
| » Lost to Reds (56-39), 3-2 | Forbes Field (21-27) | 43-51 | Lost 4 |
| » Starters: Don Gross vs Vern Law | Fifth | 15 out |
| Monday, July 30 |
| » Lost to Reds (57-39), 4-2 | Forbes Field (21-28) | 43-52 | Lost 5 |
| » Starters: Tom Acker vs Laurin Pepper | Sixth | 16 out |
| Tuesday, July 31 |
| » Lost to Cardinals (47-47), 7-0 | Forbes Field (21-29) | 43-53 | Lost 6 |
| » Starters: Murry Dickson vs Red Munger | Sixth | 16 out |
| Wednesday, August 1 |
| » Lost to Cardinals (48-47), 4-1 | Forbes Field (21-30) | 43-54 | Lost 7 |
| » Starters: Willard Schmidt vs Ron Kline | Sixth | 16 out |
| Thursday, August 2 |
| » Lost to Cardinals (49-47), 7-5 | Forbes Field (21-31) | 43-55 | Lost 8 |
| » Starters: Vinegar Bend Mizell vs Bob Friend | Sixth | 16 out |
| Friday, August 3 |
| » Defeated Braves (57-38), 4-3 | Forbes Field (22-31) | 44-55 | |
| » Starters: Warren Spahn vs Vern Law | Sixth | 15 out |
| Saturday, August 4 |
| » Lost to Braves (58-38), 7-3 | Forbes Field (22-32) | 44-56 | |
| » Starters: Bob Buhl vs Laurin Pepper | Sixth | 16 out |
| Sunday, August 5 |
| » Lost to Braves (59-38), 5-1 | Forbes Field (22-33) | 44-57 | Lost 2 |
| » Starters: Gene Conley vs Ron Kline | Sixth | 18 out |
| » Lost to Braves (60-38), 5-0 | Forbes Field (22-34) | 44-58 | Lost 3 |
| » Starters: Lew Burdette vs Bob Friend | Sixth | 18 out |
| Tuesday, August 7 |
| » Lost to Dodgers (61-42), 3-0 | Roosevelt Stadium (0-1) | 44-59 | Lost 4 |
| » Starters: Vern Law vs Don Newcombe | Sixth | 18½ out |
| Wednesday, August 8 |
| » Defeated Dodgers (61-43), 8-5 | Forbes Field (23-34) | 45-59 | |
| » Starters: Roger Craig vs Red Munger | Sixth | 18 out |
| Thursday, August 9 |
| » Lost to Dodgers (62-43), 7-3 | Forbes Field (23-35) | 45-60 | |
| » Starters: Carl Erskine vs Dick Hall | Sixth | 18½ out |
| Friday, August 10 |
| » Defeated Giants (38-64), 3-2 | Forbes Field (24-35) | 46-60 | |
| » Starters: Dick Littlefield vs Bob Friend | Sixth | 17½ out |
| Saturday, August 11 |
| » Lost to Giants (39-64), 4-2 | Forbes Field (24-36) | 46-61 | |
| » Starters: Johnny Antonelli vs Ron Kline | Sixth | 18½ out |
| Sunday, August 12 |
| » Defeated Giants (39-65), 3-2 | Forbes Field (25-36) | 47-61 | |
| » Starters: Ruben Gomez vs Vern Law | Sixth | 18 out |
| » Defeated Giants (39-66), 11-3 | Forbes Field (26-36) | 48-61 | Won 2 |
| » Starters: Windy McCall vs Fred Waters | Sixth | 18 out |
| Tuesday, August 14 |
| » Lost to Phillies (53-55), 3-0 | Shibe Park (3-1) | 48-62 | |
| » Starters: Bob Friend vs Harvey Haddix | Sixth | 19 out |
| » Lost to Phillies (54-55), 11-2 | Shibe Park (3-2) | 48-63 | Lost 2 |
| » Starters: Red Munger vs Curt Simmons | Sixth | 19 out |
| Wednesday, August 15 |
| » Defeated Phillies (54-56), 5-1 | Shibe Park (4-2) | 49-63 | |
| » Starters: Ron Kline vs Jack Meyer | Sixth | 19 out |
| Thursday, August 16 |
| » Defeated Phillies (54-57), 4-1 | Shibe Park (5-2) | 50-63 | Won 2 |
| » Starters: Vern Law vs Robin Roberts | Sixth | 19 out |
| Friday, August 17 |
| » Lost to Giants (42-67), 5-3 | Polo Grounds V (2-5) | 50-64 | |
| » Starters: Red Munger vs Joe Margoneri | Sixth | 19 out |
| Saturday, August 18 |
| » Defeated Giants (42-68), 9-1 | Polo Grounds V (3-5) | 51-64 | |
| » Starters: Bob Friend vs Ruben Gomez | Sixth | 18 out |
| Sunday, August 19 |
| » Lost to Giants (43-68), 7-6 | Polo Grounds V (3-6) | 51-65 | |
| » Starters: Roy Face vs Jim Hearn | Sixth | 19½ out |
| » Lost to Giants (44-68), 3-2 | Polo Grounds V (3-7) | 51-66 | Lost 2 |
| » Starters: Ron Kline vs Johnny Antonelli | Sixth | 19½ out |
| Tuesday, August 21 |
| » Lost to Reds (69-50), 7-4 | Crosley Field (4-6) | 51-67 | Lost 3 |
| » Starters: Vern Law vs Don Gross | Sixth | 21½ out |
| Wednesday, August 22 |
| » Lost to Reds (70-50), 6-3 | Crosley Field (4-7) | 51-68 | Lost 4 |
| » Starters: Bob Friend vs Joe Nuxhall | Sixth | 21½ out |
| Thursday, August 23 |
| » Lost to Cardinals (59-60), 3-0 | Sportsman's Park III (4-4) | 51-69 | Lost 5 |
| » Starters: Ron Kline vs Vinegar Bend Mizell | Sixth | 23 out |
| » Lost to Cardinals (60-60), 3-2 | Sportsman's Park III (4-5) | 51-70 | Lost 6 |
| » Starters: Red Munger vs Willard Schmidt | Sixth | 23 out |
| Friday, August 24 |
| » Lost to Cardinals (61-60), 6-2 | Sportsman's Park III (4-6) | 51-71 | Lost 7 |
| » Starters: Fred Waters vs Murry Dickson | Sixth | 24 out |
| Saturday, August 25 |
| » Lost to Cardinals (62-60), 8-5 | Sportsman's Park III (4-7) | 51-72 | Lost 8 |
| » Starters: Vern Law vs Herm Wehmeier | Sixth | 24 out |
| Sunday, August 26 |
| » Defeated Cubs (49-72), 2-0 | Wrigley Field (5-5) | 52-72 | |
| » Starters: Bob Friend vs Bob Rush | Sixth | 23½ out |
| » Defeated Cubs (49-73), 2-1 | Wrigley Field (6-5) | 53-72 | Won 2 |
| » Starters: Ron Kline vs Sam Jones | Sixth | 23½ out |
| Tuesday, August 28 |
| » Defeated Braves (75-49), 5-4 | County Stadium (4-5) | 54-72 | Won 3 |
| » Starters: Dick Hall vs Warren Spahn | Sixth | 22 out |
| Wednesday, August 29 |
| » Lost to Braves (76-49), 4-1 | County Stadium (4-6) | 54-73 | |
| » Starters: Vern Law vs Lew Burdette | Sixth | 23 out |
| Thursday, August 30 |
| » Tied Braves, 1-1 | County Stadium (4-6) | 54-73 | |
| » Starters: Bob Friend vs Bob Buhl | Sixth | 23 out |
| Friday, August 31 |
| » Defeated Phillies (59-65), 6-3 | Forbes Field (27-36) | 55-73 | |
| » Starters: Granny Hamner vs Ron Kline | Sixth | 23½ out |
| Saturday, September 1 |
| » Lost to Phillies (60-65), 3-2 | Forbes Field (27-37) | 55-74 | |
| » Starters: Saul Rogovin vs Dick Hall | Sixth | 24½ out |
| Sunday, September 2 |
| » Defeated Phillies (60-66), 10-6 | Forbes Field (28-37) | 56-74 | |
| » Starters: Curt Simmons vs Vern Law | Fifth | 24 out |
| » Defeated Phillies (60-67), 5-1 | Forbes Field (29-37) | 57-74 | Won 2 |
| » Starters: Robin Roberts vs Fred Waters | Fifth | 24 out |
| Monday, September 3 |
| » Lost to Dodgers (78-53), 4-3 | Ebbets Field (2-3) | 57-75 | |
| » Starters: Bob Friend vs Roger Craig | Fifth | 24 out |
| » Defeated Dodgers (78-54), 3-2 | Ebbets Field (3-3) | 58-75 | |
| » Starters: Red Munger vs Don Drysdale | Fifth | 24 out |
| Wednesday, September 5 |
| » Lost to Dodgers (79-54), 4-3 | Ebbets Field (3-4) | 58-76 | |
| » Starters: Ron Kline vs Sal Maglie | Sixth | 23½ out |
| Friday, September 7 |
| » Lost to Phillies (62-70), 5-2 | Shibe Park (5-3) | 58-77 | Lost 2 |
| » Starters: Bob Friend vs Robin Roberts | Fifth | 23½ out |
| Saturday, September 8 |
| » Defeated Phillies (62-71), 5-4 | Shibe Park (6-3) | 59-77 | |
| » Starters: Vern Law vs Saul Rogovin | Sixth | 22½ out |
| Sunday, September 9 |
| » Defeated Phillies (62-72), 4-1 | Shibe Park (7-3) | 60-77 | Won 2 |
| » Starters: Ron Kline vs Bob Miller | Sixth | 23½ out |
| » Lost to Phillies (63-72), 6-5 | Shibe Park (7-4) | 60-78 | |
| » Starters: Bob Friend vs Harvey Haddix | Sixth | 23½ out |
| Tuesday, September 11 |
| » Defeated Cubs (54-83), 4-3 | Forbes Field (30-37) | 61-78 | |
| » Starters: Bob Rush vs Dick Hall | Fifth | 22½ out |
| Wednesday, September 12 |
| » Lost to Cubs (55-83), 3-0 | Forbes Field (30-38) | 61-79 | |
| » Starters: Sam Jones vs Vern Law | Sixth | 23½ out |
| Thursday, September 13 |
| » Lost to Reds (82-58), 5-4 | Forbes Field (30-39) | 61-80 | Lost 2 |
| » Starters: Hal Jeffcoat vs Ron Kline | Sixth | 25 out |
| Saturday, September 15 |
| » Lost to Reds (83-58), 6-4 | Forbes Field (30-40) | 61-81 | Lost 3 |
| » Starters: Brooks Lawrence vs Bob Friend | Sixth | 24½ out |
| Sunday, September 16 |
| » Lost to Cardinals (72-69), 3-2 | Forbes Field (30-41) | 61-82 | Lost 4 |
| » Starters: Murry Dickson vs Fred Waters | Sixth | 25 out |
| » Defeated Cardinals (72-70), 9-3 | Forbes Field (31-41) | 62-82 | |
| » Starters: Herm Wehmeier vs Vern Law | Sixth | 25 out |
| Tuesday, September 18 |
| » Lost to Braves (88-58), 6-4 | Forbes Field (31-42) | 62-83 | |
| » Starters: Lew Burdette vs Ron Kline | Sixth | 25½ out |
| Thursday, September 20 |
| » Defeated Braves (88-59), 2-1 | Forbes Field (32-42) | 63-83 | |
| » Starters: Bob Buhl vs Bob Friend | Sixth | 25½ out |
| Friday, September 21 |
| » Defeated Dodgers (88-58), 2-1 | Forbes Field (33-42) | 64-83 | Won 2 |
| » Starters: Sal Maglie vs Ron Kline | Sixth | 24½ out |
| Saturday, September 22 |
| » Defeated Dodgers (88-59), 5-1 | Forbes Field (34-42) | 65-83 | Won 3 |
| » Starters: Carl Erskine vs Vern Law | Sixth | 23½ out |
| Former Pirate Jesse Tannehill dies in Dayton, KY at the age of 83. |
| Sunday, September 23 |
| » Lost to Dodgers (89-59), 8-3 | Forbes Field (34-43) | 65-84 | |
| » Starters: Don Newcombe vs Dick Hall | Sixth | 24½ out |
| Monday, September 24 |
| » Defeated Dodgers (89-60), 6-5 | Forbes Field (35-43) | 66-84 | |
| » Starters: Clem Labine vs Bob Friend | Sixth | 24 out |
| Tuesday, September 25 |
| » Lost to Giants (65-86), 10-0 | Polo Grounds V (3-8) | 66-85 | |
| » Starters: Ron Kline vs Johnny Antonelli | Sixth | 25 out |
| Saturday, September 29 |
| » Lost to Dodgers (91-61), 6-2 | Ebbets Field (3-5) | 66-86 | Lost 2 |
| » Starters: Bob Friend vs Sal Maglie | Seventh | 26 out |
| » Lost to Dodgers (92-61), 3-1 | Ebbets Field (3-6) | 66-87 | Lost 3 |
| » Starters: Ron Kline vs Clem Labine | Seventh | 26 out |
| Sunday, September 30 |
| » Lost to Dodgers (93-61), 8-6 | Ebbets Field (3-7) | 66-88 | Lost 4 |
| » Starters: Vern Law vs Don Newcombe | Seventh | 27 out |
| Monday, October 1 |
| Future Pirate Vance Law is born in Boise, ID. |
| Thursday, November 1 |
| Future Pirate Gary Redus is born in Athens, AL. |
| Friday, November 2 |
| Future Pirate Gary Hargis is born in Minneapolis, MN. |
| Monday, November 26 |
| Future Pirate Bob Walk is born in Van Nuys, CA. |
| Thursday, December 13 |
| Future Pirate Dale Berra is born in Ridgewood, NJ. |
Game information provided by Retrosheet (www.retrosheet.org) |
