| Wednesday, February 8 |
| Former Oriole Long Tom Hughes dies in Chicago, IL at the age of 78. |
| Friday, February 24 |
| Future Oriole Eddie Murray is born in Los Angeles, CA. |
| Saturday, February 25 |
| Future Oriole Kevin Hickey is born in Chicago, IL. |
| Tuesday, April 17 |
| » Lost to Red Sox (1-0), 8-1 | Fenway Park (0-1) | 0-1 | |
| » Starters: Bill Wight vs Frank Sullivan | Second | 1 out |
| » Major-league debuts: Don Buddin (Red Sox) Tito Francona (Orioles) |
| Wednesday, April 18 |
| » Lost to Red Sox (2-0), 8-4 | Fenway Park (0-2) | 0-2 | Lost 2 |
| » Starters: Ray Moore vs Bob Porterfield | Fourth | 2 out |
| Thursday, April 19 |
| » Lost to Red Sox (3-0), 4-2 | Fenway Park (0-3) | 0-3 | Lost 3 |
| » Starters: Erv Palica vs Tom Brewer | Sixth | 3 out |
| Friday, April 20 |
| » Defeated Senators (1-3), 3-2 | Memorial Stadium (1-0) | 1-3 | |
| » Starters: Dick Brodowski vs Jim Wilson | Fifth | 2½ out |
| Saturday, April 21 |
| » Lost to Senators (2-3), 8-4 | Memorial Stadium (1-1) | 1-4 | |
| » Starters: Dean Stone vs Bill Wight | Sixth | 3 out |
| Sunday, April 22 |
| » Defeated Senators (2-4), 7-3 | Memorial Stadium (2-1) | 2-4 | |
| » Starters: Bob Wiesler vs Fred Besana | Seventh | 3½ out |
| » Lost to Senators (3-4), 4-1 | Memorial Stadium (2-2) | 2-5 | |
| » Starters: Camilo Pascual vs Ray Moore | Seventh | 3½ out |
| Wednesday, April 25 |
| » Lost to Yankees (7-1), 4-2 | Memorial Stadium (2-3) | 2-6 | Lost 2 |
| » Starters: Whitey Ford vs Erv Palica | Fifth | 5 out |
| Thursday, April 26 |
| » Defeated Yankees (7-2), 7-5 | Memorial Stadium (3-3) | 3-6 | |
| » Starters: Tommy Byrne vs Jim Wilson | Seventh | 3 out |
| Friday, April 27 |
| » Lost to Senators (5-5), 8-5 | Griffith Stadium (0-1) | 3-7 | |
| » Starters: Fred Besana vs Dean Stone | Seventh | 4 out |
| Saturday, April 28 |
| » Lost to Senators (6-5), 5-3 | Griffith Stadium (0-2) | 3-8 | Lost 2 |
| » Starters: Bill Wight vs Camilo Pascual | Eighth | 4½ out |
| Sunday, April 29 |
| » Defeated Senators (6-6), 8-6 | Griffith Stadium (1-2) | 4-8 | |
| » Starters: Ray Moore vs Chuck Stobbs | Eighth | 4½ out |
| » Lost to Senators (7-6), 5-4 | Griffith Stadium (1-3) | 4-9 | |
| » Starters: Jim Wilson vs Bob Wiesler | Eighth | 4½ out |
| Tuesday, May 1 |
| » Defeated White Sox (5-2), 3-2 | Memorial Stadium (4-3) | 5-9 | |
| » Starters: Jack Harshman vs Erv Palica | Seventh | 5 out |
| Thursday, May 3 |
| » Lost to Indians (8-5), 7-1 | Memorial Stadium (4-4) | 5-10 | |
| » Starters: Mike Garcia vs Bill Wight | Eighth | 4½ out |
| Friday, May 4 |
| » Defeated Indians (8-6), 4-3 | Memorial Stadium (5-4) | 6-10 | |
| » Starters: Herb Score vs Jim Wilson | Seventh | 4½ out |
| Saturday, May 5 |
| » Lost to Indians (9-6), 2-1 | Memorial Stadium (5-5) | 6-11 | |
| » Starters: Bob Lemon vs Don Ferrarese | Eighth | 5½ out |
| Sunday, May 6 |
| » Defeated Tigers (6-10), 6-2 | Memorial Stadium (6-5) | 7-11 | |
| » Starters: Steve Gromek vs Ray Moore | Seventh | 5½ out |
| » Defeated Tigers (6-11), 4-3 | Memorial Stadium (7-5) | 8-11 | Won 2 |
| » Starters: Frank Lary vs Erv Palica | Seventh | 5½ out |
| Monday, May 7 |
| » Defeated Tigers (6-12), 4-3 | Memorial Stadium (8-5) | 9-11 | Won 3 |
| » Starters: Virgil Trucks vs Bill Wight | Sixth | 5 out |
| Tuesday, May 8 |
| » Defeated Athletics (7-10), 7-4 | Memorial Stadium (9-5) | 10-11 | Won 4 |
| » Starters: Art Ceccarelli vs Hal Brown | Fourth | 5 out |
| Wednesday, May 9 |
| » Lost to Athletics (8-10), 4-0 | Memorial Stadium (9-6) | 10-12 | |
| » Starters: Art Ditmar vs Jim Wilson | Fourth | 5 out |
| Friday, May 11 |
| » Lost to Yankees (15-7), 3-2 | Yankee Stadium (0-1) | 10-13 | Lost 2 |
| » Starters: Erv Palica vs Whitey Ford | Sixth | 5½ out |
| Saturday, May 12 |
| » Defeated Yankees (15-8), 1-0 | Yankee Stadium (1-1) | 11-13 | |
| » Starters: Don Ferrarese vs Bob Turley | Sixth | 4½ out |
| Sunday, May 13 |
| » Lost to Yankees (16-8), 11-2 | Yankee Stadium (1-2) | 11-14 | |
| » Starters: Ray Moore vs Don Larsen | Fifth | 4½ out |
| » Defeated Yankees (16-9), 5-1 | Yankee Stadium (2-2) | 12-14 | |
| » Starters: Bill Wight vs Tom Sturdivant | Fifth | 4½ out |
| Tuesday, May 15 |
| » Defeated Athletics (9-14), 9-5 | Municipal Stadium (1-0) | 13-14 | Won 2 |
| » Starters: Jim Wilson vs Lou Kretlow | Fifth | 3½ out |
| Wednesday, May 16 |
| » Defeated Athletics (9-15), 8-6 | Municipal Stadium (2-0) | 14-14 | Won 3 |
| » Starters: Erv Palica vs Tom Lasorda | Fifth | 3½ out |
| Friday, May 18 |
| » Lost to Tigers (10-16), 3-2 | Tiger Stadium (0-1) | 14-15 | |
| » Starters: Don Ferrarese vs Billy Hoeft | Fifth | 5 out |
| Saturday, May 19 |
| » Defeated Tigers (10-17), 5-4 | Tiger Stadium (1-1) | 15-15 | |
| » Starters: Bill Wight vs Duke Maas | Fifth | 5 out |
| Sunday, May 20 |
| » Lost to Indians (17-11), 6-1 | Cleveland Stadium (0-1) | 15-16 | |
| » Starters: Jim Wilson vs Bob Lemon | Fifth | 6½ out |
| » Lost to Indians (18-11), 5-1 | Cleveland Stadium (0-2) | 15-17 | Lost 2 |
| » Starters: Erv Palica vs Mike Garcia | Fifth | 6½ out |
| Wednesday, May 23 |
| » Lost to White Sox (13-13), 3-2 | Comiskey Park I (0-1) | 15-18 | Lost 3 |
| » Starters: Johnny Schmitz vs Jack Harshman | Fifth | 7½ out |
| Friday, May 25 |
| » Lost to Yankees (25-11), 10-2 | Memorial Stadium (9-7) | 15-19 | Lost 4 |
| » Starters: Johnny Kucks vs Don Ferrarese | Fifth | 9 out |
| Saturday, May 26 |
| » Defeated Yankees (25-12), 9-4 | Memorial Stadium (10-7) | 16-19 | |
| » Starters: Mickey McDermott vs Bill Wight | Fifth | 8 out |
| Monday, May 28 |
| » Defeated Senators (15-22), 6-5 | Memorial Stadium (11-7) | 17-19 | Won 2 |
| » Starters: Bob Wiesler vs Connie Johnson | Fifth | 8 out |
| Tuesday, May 29 |
| » Lost to Senators (16-22), 6-5 | Memorial Stadium (11-8) | 17-20 | |
| » Starters: Dean Stone vs Erv Palica | Fifth | 8 out |
| Wednesday, May 30 |
| » Defeated Red Sox (19-18), 2-1 | Memorial Stadium (12-8) | 18-20 | |
| » Starters: Ike Delock vs Ray Moore | Fifth | 8 out |
| » Defeated Red Sox (19-19), 5-4 | Memorial Stadium (13-8) | 19-20 | Won 2 |
| » Starters: George Susce vs Hal Brown | Fifth | 8 out |
| Thursday, May 31 |
| » Lost to Red Sox (20-19), 4-1 | Memorial Stadium (13-9) | 19-21 | |
| » Starters: Bob Porterfield vs Bill Wight | Fifth | 9 out |
| Friday, June 1 |
| » Defeated White Sox (18-16), 3-2 | Memorial Stadium (14-9) | 20-21 | |
| » Starters: Bob Keegan vs Connie Johnson | Fifth | 8 out |
| Sunday, June 3 |
| » Lost to White Sox (19-16), 12-0 | Memorial Stadium (14-10) | 20-22 | |
| » Starters: Dick Donovan vs Erv Palica | Fifth | 8 out |
| » Lost to White Sox (20-16), 9-2 | Memorial Stadium (14-11) | 20-23 | Lost 2 |
| » Starters: Jim Wilson vs Mike Fornieles | Fifth | 8 out |
| Monday, June 4 |
| » Lost to White Sox (21-16), 13-4 | Memorial Stadium (14-12) | 20-24 | Lost 3 |
| » Starters: Billy Pierce vs Don Ferrarese | Fifth | 8½ out |
| Future Oriole Terry Kennedy is born in Euclid, OH. |
| Tuesday, June 5 |
| » Lost to Indians (24-19), 8-3 | Memorial Stadium (14-13) | 20-25 | Lost 4 |
| » Starters: Bob Lemon vs Ray Moore | Sixth | 8½ out |
| Wednesday, June 6 |
| » Lost to Indians (25-19), 5-1 | Memorial Stadium (14-14) | 20-26 | Lost 5 |
| » Starters: Art Houtteman vs Connie Johnson | Fifth | 9½ out |
| Thursday, June 7 |
| » Defeated Indians (25-20), 5-2 | Memorial Stadium (15-14) | 21-26 | |
| » Starters: Cal McLish vs Bill Wight | Sixth | 9½ out |
| Friday, June 8 |
| » Defeated Athletics (18-28), 6-3 | Memorial Stadium (16-14) | 22-26 | Won 2 |
| » Starters: Art Ditmar vs Erv Palica | Sixth | 8½ out |
| Saturday, June 9 |
| » Defeated Athletics (18-29), 4-1 | Memorial Stadium (17-14) | 23-26 | Won 3 |
| » Starters: Troy Herriage vs Ray Moore | Fifth | 7 out |
| » Defeated Athletics (18-30), 7-5 | Memorial Stadium (18-14) | 24-26 | Won 4 |
| » Starters: Tom Gorman vs Mike Fornieles | Fifth | 7 out |
| Sunday, June 10 |
| » Lost to Athletics (19-30), 7-3 | Memorial Stadium (18-15) | 24-27 | |
| » Starters: Jose Santiago vs Connie Johnson | Sixth | 8 out |
| Monday, June 11 |
| » Defeated Tigers (24-26), 5-4 | Memorial Stadium (19-15) | 25-27 | |
| » Starters: Frank Lary vs Don Ferrarese | Fifth | 7½ out |
| Tuesday, June 12 |
| » Lost to Tigers (25-26), 8-1 | Memorial Stadium (19-16) | 25-28 | |
| » Starters: Billy Hoeft vs Bill Wight | Sixth | 8½ out |
| Wednesday, June 13 |
| » Lost to Tigers (26-26), 2-0 | Memorial Stadium (19-17) | 25-29 | Lost 2 |
| » Starters: Paul Foytack vs Billy Loes | Sixth | 8½ out |
| Friday, June 15 |
| » Defeated Athletics (22-32), 1-0 | Municipal Stadium (3-0) | 26-29 | |
| » Starters: Ray Moore vs Lou Kretlow | Fifth | 9 out |
| Saturday, June 16 |
| » Defeated Athletics (22-33), 6-2 | Municipal Stadium (4-0) | 27-29 | Won 2 |
| » Starters: Connie Johnson vs Jack Crimian | Fifth | 9 out |
| Sunday, June 17 |
| » Defeated Athletics (22-34), 7-2 | Municipal Stadium (5-0) | 28-29 | Won 3 |
| » Starters: Hal Brown vs Art Ditmar | Sixth | 9 out |
| Monday, June 18 |
| » Lost to White Sox (29-22), 5-2 | Comiskey Park I (0-2) | 28-30 | |
| » Starters: Bill Wight vs Jim Wilson | Fifth | 10 out |
| Tuesday, June 19 |
| » Lost to White Sox (30-22), 5-1 | Comiskey Park I (0-3) | 28-31 | Lost 2 |
| » Starters: Ray Moore vs Billy Pierce | Fourth | 11 out |
| Wednesday, June 20 |
| » Lost to White Sox (31-22), 12-8 | Comiskey Park I (0-4) | 28-32 | Lost 3 |
| » Starters: Billy Loes vs Howie Pollet | Fifth | 12 out |
| Thursday, June 21 |
| » Lost to White Sox (32-22), 1-0 | Comiskey Park I (0-5) | 28-33 | Lost 4 |
| » Starters: Connie Johnson vs Jack Harshman | Sixth | 12½ out |
| Future Oriole Rick Sutcliffe is born in Independence, MO. |
| Friday, June 22 |
| » Defeated Tigers (27-32), 3-2 | Tiger Stadium (2-1) | 29-33 | |
| » Starters: Bill Wight vs Paul Foytack | Fifth | 11½ out |
| Sunday, June 24 |
| » Defeated Tigers (27-33), 3-2 | Tiger Stadium (3-1) | 30-33 | Won 2 |
| » Starters: Billy Loes vs Steve Gromek | Fifth | 9 out |
| » Defeated Tigers (27-34), 3-2 | Tiger Stadium (4-1) | 31-33 | Won 3 |
| » Starters: Ray Moore vs Frank Lary | Fifth | 9 out |
| Tuesday, June 26 |
| » Lost to Indians (35-27), 4-3 | Cleveland Stadium (0-3) | 31-34 | |
| » Starters: Connie Johnson vs Early Wynn | Fifth | 10½ out |
| Wednesday, June 27 |
| » Lost to Indians (36-27), 12-11 | Cleveland Stadium (0-4) | 31-35 | Lost 2 |
| » Starters: Bill Wight vs Mike Garcia | Fifth | 11½ out |
| Friday, June 29 |
| » Lost to Red Sox (33-31), 7-6 | Memorial Stadium (19-18) | 31-36 | Lost 3 |
| » Starters: Mel Parnell vs Ray Moore | Fifth | 12½ out |
| Saturday, June 30 |
| » Lost to Red Sox (34-31), 4-2 | Memorial Stadium (19-19) | 31-37 | Lost 4 |
| » Starters: Willard Nixon vs Billy Loes | Sixth | 13 out |
| » Lost to Red Sox (35-31), 6-3 | Memorial Stadium (19-20) | 31-38 | Lost 5 |
| » Starters: Tom Brewer vs Don Ferrarese | Sixth | 13 out |
| Sunday, July 1 |
| » Defeated Red Sox (35-32), 5-3 | Memorial Stadium (20-20) | 32-38 | |
| » Starters: Bob Porterfield vs Connie Johnson | Fifth | 13½ out |
| Tuesday, July 3 |
| » Lost to Yankees (47-25), 4-3 | Yankee Stadium (2-3) | 32-39 | |
| » Starters: Bill Wight vs Rip Coleman | Fifth | 14½ out |
| Wednesday, July 4 |
| » Lost to Senators (31-46), 10-8 | Griffith Stadium (1-4) | 32-40 | Lost 2 |
| » Starters: Hal Brown vs Chuck Stobbs | Fifth | 14½ out |
| » Defeated Senators (31-47), 7-4 | Griffith Stadium (2-4) | 33-40 | |
| » Starters: Connie Johnson vs Hal Griggs | Fifth | 14½ out |
| Saturday, July 7 |
| » Lost to Red Sox (38-35), 4-3 | Fenway Park (0-4) | 33-41 | |
| » Starters: Billy Loes vs Tom Brewer | Fifth | 16½ out |
| Sunday, July 8 |
| » Lost to Red Sox (39-35), 9-0 | Fenway Park (0-5) | 33-42 | Lost 2 |
| » Starters: Ray Moore vs Frank Sullivan | Sixth | 18 out |
| » Lost to Red Sox (40-35), 8-4 | Fenway Park (0-6) | 33-43 | Lost 3 |
| » Starters: Connie Johnson vs Willard Nixon | Sixth | 18 out |
| Thursday, July 12 |
| » Defeated Athletics (28-49), 4-0 | Memorial Stadium (21-20) | 34-43 | |
| » Starters: Art Ditmar vs Bill Wight | Sixth | 18 out |
| Friday, July 13 |
| » Lost to Athletics (29-49), 3-2 | Memorial Stadium (21-21) | 34-44 | |
| » Starters: Alex Kellner vs Connie Johnson | Sixth | 19 out |
| Saturday, July 14 |
| » Defeated Athletics (29-50), 1-0 | Memorial Stadium (22-21) | 35-44 | |
| » Starters: Jack McMahan vs Mike Fornieles | Sixth | 19 out |
| Sunday, July 15 |
| » Defeated Tigers (36-44), 7-2 | Memorial Stadium (23-21) | 36-44 | Won 2 |
| » Starters: Ned Garver vs Ray Moore | Fifth | 19 out |
| » Defeated Tigers (36-45), 6-3 | Memorial Stadium (24-21) | 37-44 | Won 3 |
| » Starters: Virgil Trucks vs Hal Brown | Fifth | 19 out |
| Tuesday, July 17 |
| » Defeated White Sox (43-36), 5-3 | Memorial Stadium (25-21) | 38-44 | Won 4 |
| » Starters: Jack Harshman vs Don Ferrarese | Fifth | 18½ out |
| » Defeated White Sox (43-37), 5-3 | Memorial Stadium (26-21) | 39-44 | Won 5 |
| » Starters: Bob Keegan vs Bill Wight | Fifth | 18½ out |
| Wednesday, July 18 |
| » Defeated White Sox (43-38), 4-3 | Memorial Stadium (27-21) | 40-44 | Won 6 |
| » Starters: Jim Wilson vs Connie Johnson | Fifth | 17 out |
| Thursday, July 19 |
| » Lost to White Sox (44-38), 3-2 | Memorial Stadium (27-22) | 40-45 | |
| » Starters: Billy Pierce vs Mike Fornieles | Fifth | 18 out |
| Saturday, July 21 |
| » Lost to Indians (48-37), 4-3 | Memorial Stadium (27-23) | 40-46 | Lost 2 |
| » Starters: Bob Lemon vs Ray Moore | Fifth | 19½ out |
| » Lost to Indians (49-37), 4-3 | Memorial Stadium (27-24) | 40-47 | Lost 3 |
| » Starters: Herb Score vs Hal Brown | Fifth | 19½ out |
| Sunday, July 22 |
| » Lost to Indians (50-37), 8-0 | Memorial Stadium (27-25) | 40-48 | Lost 4 |
| » Starters: Early Wynn vs Bill Wight | Fifth | 20 out |
| Tuesday, July 24 |
| » Lost to Tigers (40-49), 9-7 | Tiger Stadium (4-2) | 40-49 | Lost 5 |
| » Starters: Connie Johnson vs Paul Foytack | Fifth | 19½ out |
| » Defeated Tigers (40-50), 11-5 | Tiger Stadium (5-2) | 41-49 | |
| » Starters: Don Ferrarese vs Bob Miller | Fifth | 19½ out |
| Wednesday, July 25 |
| » Lost to Tigers (41-50), 6-2 | Tiger Stadium (5-3) | 41-50 | |
| » Starters: Ray Moore vs Virgil Trucks | Fifth | 20½ out |
| Thursday, July 26 |
| » Defeated Tigers (41-51), 11-6 | Tiger Stadium (6-3) | 42-50 | |
| » Starters: Bill Wight vs Billy Hoeft | Fifth | 20½ out |
| Friday, July 27 |
| » Lost to Indians (54-37), 3-2 | Cleveland Stadium (0-5) | 42-51 | |
| » Starters: Johnny Schmitz vs Early Wynn | Fifth | 21½ out |
| Saturday, July 28 |
| » Defeated Indians (54-38), 8-6 | Cleveland Stadium (1-5) | 43-51 | |
| » Starters: Connie Johnson vs Mike Garcia | Fifth | 21½ out |
| Sunday, July 29 |
| » Lost to Indians (55-38), 3-0 | Cleveland Stadium (1-6) | 43-52 | |
| » Starters: Erv Palica vs Herb Score | Fifth | 23 out |
| » Lost to Indians (56-38), 4-0 | Cleveland Stadium (1-7) | 43-53 | Lost 2 |
| » Starters: Don Ferrarese vs Hank Aguirre | Fifth | 23 out |
| Monday, July 30 |
| » Defeated Athletics (34-62), 4-3 | Municipal Stadium (6-0) | 44-53 | |
| » Starters: Ray Moore vs Wally Burnette | Fifth | 23 out |
| Tuesday, July 31 |
| » Defeated Athletics (34-63), 5-1 | Municipal Stadium (7-0) | 45-53 | Won 2 |
| » Starters: Hal Brown vs Troy Herriage | Fifth | 22 out |
| Wednesday, August 1 |
| » Lost to Athletics (35-63), 9-4 | Municipal Stadium (7-1) | 45-54 | |
| » Starters: Connie Johnson vs Lou Kretlow | Fifth | 22 out |
| Thursday, August 2 |
| » Lost to Athletics (36-63), 3-2 | Municipal Stadium (7-2) | 45-55 | Lost 2 |
| » Starters: Mike Fornieles vs Alex Kellner | Fifth | 22 out |
| Friday, August 3 |
| » Lost to White Sox (50-46), 13-3 | Comiskey Park I (0-6) | 45-56 | Lost 3 |
| » Starters: Johnny Schmitz vs Billy Pierce | Sixth | 22 out |
| Saturday, August 4 |
| » Lost to White Sox (51-46), 15-4 | Comiskey Park I (0-7) | 45-57 | Lost 4 |
| » Starters: Bill Wight vs Jack Harshman | Sixth | 22 out |
| Sunday, August 5 |
| » Defeated White Sox (51-47), 5-4 | Comiskey Park I (1-7) | 46-57 | |
| » Starters: Don Ferrarese vs Dick Donovan | Sixth | 20½ out |
| » Defeated White Sox (51-48), 7-2 | Comiskey Park I (2-7) | 47-57 | Won 2 |
| » Starters: Ray Moore vs Jim Wilson | Sixth | 20½ out |
| Monday, August 6 |
| » Major-league debuts: Ralph Terry (Yankees) |
| Wednesday, August 8 |
| » Lost to Red Sox (60-45), 7-2 | Fenway Park (0-7) | 47-58 | |
| » Starters: Connie Johnson vs Mel Parnell | Sixth | 21½ out |
| Thursday, August 9 |
| » Lost to Red Sox (61-45), 3-1 | Fenway Park (0-8) | 47-59 | Lost 2 |
| » Starters: Mike Fornieles vs Frank Sullivan | Sixth | 22½ out |
| Friday, August 10 |
| » Lost to Yankees (71-37), 5-4 | Yankee Stadium (2-4) | 47-60 | Lost 3 |
| » Starters: Ray Moore vs Whitey Ford | Sixth | 23½ out |
| Saturday, August 11 |
| » Defeated Yankees (71-38), 10-5 | Yankee Stadium (3-4) | 48-60 | |
| » Starters: Hal Brown vs Ralph Terry | Sixth | 22½ out |
| Sunday, August 12 |
| » Lost to Yankees (72-38), 6-2 | Yankee Stadium (3-5) | 48-61 | |
| » Starters: Don Ferrarese vs Don Larsen | Sixth | 24½ out |
| » Lost to Yankees (73-38), 4-2 | Yankee Stadium (3-6) | 48-62 | Lost 2 |
| » Starters: Bill Wight vs Bob Turley | Sixth | 24½ out |
| Tuesday, August 14 |
| » Defeated Senators (45-65), 3-0 | Memorial Stadium (28-25) | 49-62 | |
| » Starters: Chuck Stobbs vs Connie Johnson | Sixth | 24½ out |
| Wednesday, August 15 |
| » Defeated Senators (45-66), 3-2 | Memorial Stadium (29-25) | 50-62 | Won 2 |
| » Starters: Camilo Pascual vs Mike Fornieles | Sixth | 24½ out |
| Friday, August 17 |
| » Defeated Yankees (75-40), 6-4 | Memorial Stadium (30-25) | 51-62 | Won 3 |
| » Starters: Ralph Terry vs Ray Moore | Sixth | 23 out |
| Saturday, August 18 |
| » Lost to Yankees (76-40), 4-1 | Memorial Stadium (30-26) | 51-63 | |
| » Starters: Tom Sturdivant vs Hal Brown | Sixth | 25 out |
| » Lost to Yankees (77-40), 6-2 | Memorial Stadium (30-27) | 51-64 | Lost 2 |
| » Starters: Bob Turley vs Erv Palica | Sixth | 25 out |
| Sunday, August 19 |
| » Defeated Yankees (77-41), 3-2 | Memorial Stadium (31-27) | 52-64 | |
| » Starters: Johnny Kucks vs Connie Johnson | Sixth | 24 out |
| Tuesday, August 21 |
| » Defeated Athletics (38-79), 4-3 | Memorial Stadium (32-27) | 53-64 | Won 2 |
| » Starters: Alex Kellner vs Bill Wight | Sixth | 23 out |
| Wednesday, August 22 |
| » Lost to Athletics (39-79), 7-2 | Memorial Stadium (32-28) | 53-65 | |
| » Starters: Wally Burnette vs Mike Fornieles | Sixth | 24 out |
| Thursday, August 23 |
| » Defeated Tigers (57-63), 3-0 | Memorial Stadium (33-28) | 54-65 | |
| » Starters: Frank Lary vs Ray Moore | Sixth | 22½ out |
| Friday, August 24 |
| » Lost to Tigers (58-63), 4-1 | Memorial Stadium (33-29) | 54-66 | |
| » Starters: Billy Hoeft vs Connie Johnson | Sixth | 23½ out |
| Saturday, August 25 |
| » Lost to Tigers (59-63), 7-3 | Memorial Stadium (33-30) | 54-67 | Lost 2 |
| » Starters: Jim Bunning vs Don Ferrarese | Sixth | 23½ out |
| Sunday, August 26 |
| » Defeated White Sox (66-54), 8-1 | Memorial Stadium (34-30) | 55-67 | |
| » Starters: Billy Pierce vs Bill Wight | Sixth | 23½ out |
| » Lost to White Sox (67-54), 5-1 | Memorial Stadium (34-31) | 55-68 | |
| » Starters: Gerry Staley vs Hal Brown | Sixth | 23½ out |
| Tuesday, August 28 |
| » Defeated Indians (71-52), 1-0 | Memorial Stadium (35-31) | 56-68 | |
| » Starters: Hank Aguirre vs Ray Moore | Sixth | 23½ out |
| Wednesday, August 29 |
| » Lost to Indians (72-52), 3-2 | Memorial Stadium (35-32) | 56-69 | |
| » Starters: Mike Garcia vs Mike Fornieles | Sixth | 24½ out |
| Friday, August 31 |
| » Defeated Red Sox (68-58), 13-6 | Fenway Park (1-8) | 57-69 | |
| » Starters: Connie Johnson vs Willard Nixon | Sixth | 24½ out |
| Saturday, September 1 |
| » Lost to Red Sox (69-58), 4-2 | Fenway Park (1-9) | 57-70 | |
| » Starters: Hal Brown vs Frank Sullivan | Sixth | 24½ out |
| Sunday, September 2 |
| » Defeated Red Sox (69-59), 11-10 | Fenway Park (2-9) | 58-70 | |
| » Starters: Ray Moore vs Bob Porterfield | Sixth | 23½ out |
| Monday, September 3 |
| » Lost to Yankees (84-48), 6-1 | Yankee Stadium (3-7) | 58-71 | |
| » Starters: Erv Palica vs Johnny Kucks | Sixth | 25½ out |
| » Lost to Yankees (85-48), 5-0 | Yankee Stadium (3-8) | 58-72 | Lost 2 |
| » Starters: Bill Wight vs Don Larsen | Sixth | 25½ out |
| Wednesday, September 5 |
| » Lost to Senators (55-77), 2-0 | Griffith Stadium (2-5) | 58-73 | Lost 3 |
| » Starters: Connie Johnson vs Chuck Stobbs | Sixth | 26½ out |
| Thursday, September 6 |
| » Lost to Senators (56-77), 7-5 | Griffith Stadium (2-6) | 58-74 | Lost 4 |
| » Starters: Ray Moore vs Dean Stone | Sixth | 27 out |
| Friday, September 7 |
| » Lost to Red Sox (73-60), 7-5 | Memorial Stadium (35-33) | 58-75 | Lost 5 |
| » Starters: Mel Parnell vs Mike Fornieles | Sixth | 26½ out |
| » Defeated Red Sox (73-61), 5-0 | Memorial Stadium (36-33) | 59-75 | |
| » Starters: Frank Sullivan vs Hal Brown | Sixth | 26½ out |
| Saturday, September 8 |
| » Lost to Red Sox (74-61), 6-1 | Memorial Stadium (36-34) | 59-76 | |
| » Starters: Tom Brewer vs Billy Loes | Fifth | 27½ out |
| » Major-league debuts: Ron Moeller (Orioles) |
| Sunday, September 9 |
| » Lost to Red Sox (75-61), 3-2 | Memorial Stadium (36-35) | 59-77 | Lost 2 |
| » Starters: Dave Sisler vs Connie Johnson | Fifth | 28½ out |
| Tuesday, September 11 |
| » Lost to Indians (77-59), 3-1 | Cleveland Stadium (1-8) | 59-78 | Lost 3 |
| » Starters: Ray Moore vs Bob Lemon | Sixth | 29½ out |
| Wednesday, September 12 |
| » Lost to Indians (78-59), 2-1 | Cleveland Stadium (1-9) | 59-79 | Lost 4 |
| » Starters: Hal Brown vs Early Wynn | Sixth | 29½ out |
| Future Oriole Mark Thurmond is born in Houston, TX. |
| Thursday, September 13 |
| » Defeated Indians (78-60), 4-1 | Cleveland Stadium (2-9) | 60-79 | |
| » Starters: Connie Johnson vs Hank Aguirre | Sixth | 29½ out |
| Friday, September 14 |
| » Lost to White Sox (78-61), 3-2 | Comiskey Park I (2-8) | 60-80 | |
| » Starters: Bill Wight vs Dick Donovan | Sixth | 30½ out |
| Saturday, September 15 |
| » Defeated White Sox (78-62), 4-1 | Comiskey Park I (3-8) | 61-80 | |
| » Starters: Billy O'Dell vs Jim Wilson | Sixth | 29½ out |
| Future Oriole John Pacella is born in Brooklyn, NY. |
| Sunday, September 16 |
| » Defeated Athletics (45-96), 3-2 | Municipal Stadium (8-2) | 62-80 | Won 2 |
| » Starters: Ray Moore vs Glenn Cox | Sixth | 29½ out |
| » Lost to Athletics (46-96), 10-1 | Municipal Stadium (8-3) | 62-81 | |
| » Starters: Mike Fornieles vs Art Ditmar | Sixth | 29½ out |
| Tuesday, September 18 |
| » Lost to Tigers (76-68), 6-2 | Tiger Stadium (6-4) | 62-82 | Lost 2 |
| » Starters: Connie Johnson vs Paul Foytack | Sixth | 30½ out |
| Wednesday, September 19 |
| » Lost to Tigers (77-68), 9-1 | Tiger Stadium (6-5) | 62-83 | Lost 3 |
| » Starters: Hal Brown vs Frank Lary | Sixth | 31 out |
| » Major-league debuts: Gordie Sundin (Orioles) |
| Thursday, September 20 |
| Former Oriole Tommy Gastall dies in Riviera Beach, MD at the age of 25. |
| Friday, September 21 |
| » Defeated Senators (58-89), 7-3 | Memorial Stadium (37-35) | 63-83 | |
| » Starters: Camilo Pascual vs Bill Wight | Sixth | 30 out |
| Saturday, September 22 |
| » Defeated Senators (58-90), 8-6 | Memorial Stadium (38-35) | 64-83 | Won 2 |
| » Starters: Evelio Hernandez vs Ray Moore | Sixth | 30 out |
| Sunday, September 23 |
| » Defeated Senators (58-91), 6-0 | Memorial Stadium (39-35) | 65-83 | Won 3 |
| » Starters: Chuck Stobbs vs Connie Johnson | Sixth | 30 out |
| Monday, September 24 |
| » Defeated Yankees (95-54), 5-4 | Memorial Stadium (40-35) | 66-83 | Won 4 |
| » Starters: Johnny Kucks vs Erv Palica | Sixth | 29 out |
| Tuesday, September 25 |
| » Lost to Yankees (96-54), 11-6 | Memorial Stadium (40-36) | 66-84 | |
| » Starters: Tom Sturdivant vs Bob Harrison | Sixth | 30 out |
| Wednesday, September 26 |
| » Defeated Yankees (96-55), 1-0 | Memorial Stadium (41-36) | 67-84 | |
| » Starters: Whitey Ford vs Charlie Beamon | Sixth | 29 out |
| Saturday, September 29 |
| » Lost to Senators (59-93), 7-1 | Griffith Stadium (2-7) | 67-85 | |
| » Starters: Ron Moeller vs Evelio Hernandez | Sixth | 29½ out |
| Sunday, September 30 |
| » Defeated Senators (59-94), 4-2 | Griffith Stadium (3-7) | 68-85 | |
| » Starters: Sandy Consuegra vs Chuck Stobbs | Sixth | 28 out |
| » Defeated Senators (59-95), 6-3 | Griffith Stadium (4-7) | 69-85 | Won 2 |
| » Starters: Don Ferrarese vs Ted Abernathy | Sixth | 28 out |
| Thursday, November 29 |
| Future Oriole Joe Price is born in Inglewood, CA. |
| Wednesday, December 5 |
| Future Oriole Bill Swaggerty is born in Sanford, FL. |
| Saturday, December 29 |
| Future Oriole Dave Ford is born in Cleveland, OH. |
Game information provided by Retrosheet (www.retrosheet.org) |
