| Tuesday, January 10 |
| Future Indian Dan Rohn is born in Alpena, MI. |
| Saturday, February 4 |
| Future Indian Chris Bando is born in Cleveland, OH. |
| Friday, February 24 |
| Future Indian Eddie Murray is born in Los Angeles, CA. |
| Tuesday, April 17 |
| » Lost to White Sox (1-0), 2-1 | Comiskey Park I (0-1) | 0-1 | |
| » Starters: Bob Lemon vs Billy Pierce | Second | 1 out |
| » Major-league debuts: Luis Aparicio (White Sox) |
| Thursday, April 19 |
| » Lost to White Sox (2-0), 1-0 | Comiskey Park I (0-2) | 0-2 | Lost 2 |
| » Starters: Herb Score vs Jack Harshman | Fifth | 2½ out |
| » Major-league debuts: Earl Averill (Indians) |
| Friday, April 20 |
| » Defeated Tigers (0-3), 3-1 | Cleveland Stadium (1-0) | 1-2 | |
| » Starters: Ned Garver vs Early Wynn | Fourth | 2 out |
| Saturday, April 21 |
| » Lost to Tigers (1-3), 7-6 | Cleveland Stadium (1-1) | 1-3 | |
| » Starters: Bob Miller vs Mike Garcia | Fifth | 2½ out |
| Sunday, April 22 |
| » Lost to Tigers (2-3), 6-4 | Cleveland Stadium (1-2) | 1-4 | Lost 2 |
| » Starters: Frank Lary vs Bob Feller | Sixth | 3 out |
| » Defeated Tigers (2-4), 5-2 | Cleveland Stadium (2-2) | 2-4 | |
| » Starters: Dick Marlowe vs Bob Lemon | Sixth | 3 out |
| Wednesday, April 25 |
| » Defeated Athletics (3-4), 5-2 | Municipal Stadium (1-0) | 3-4 | Won 2 |
| » Starters: Herb Score vs Bobby Shantz | Fourth | 3½ out |
| Thursday, April 26 |
| » Defeated Athletics (3-5), 14-2 | Municipal Stadium (2-0) | 4-4 | Won 3 |
| » Starters: Early Wynn vs Lou Kretlow | Third | 1½ out |
| Friday, April 27 |
| » Defeated Tigers (3-5), 4-3 | Tiger Stadium (1-0) | 5-4 | Won 4 |
| » Starters: Mike Garcia vs Frank Lary | Third | 1½ out |
| Sunday, April 29 |
| » Lost to Tigers (4-5), 1-0 | Tiger Stadium (1-1) | 5-5 | |
| » Starters: Herb Score vs Billy Hoeft | Third | 2½ out |
| » Defeated Tigers (4-6), 8-4 | Tiger Stadium (2-1) | 6-5 | |
| » Starters: Bob Lemon vs Bud Black | Third | 2½ out |
| Tuesday, May 1 |
| » Defeated Senators (7-7), 3-2 | Griffith Stadium (1-0) | 7-5 | Won 2 |
| » Starters: Early Wynn vs Pedro Ramos | Third | 2 out |
| Thursday, May 3 |
| » Defeated Orioles (5-10), 7-1 | Memorial Stadium (1-0) | 8-5 | Won 3 |
| » Starters: Mike Garcia vs Bill Wight | Third | ½ out |
| Friday, May 4 |
| » Lost to Orioles (6-10), 4-3 | Memorial Stadium (1-1) | 8-6 | |
| » Starters: Herb Score vs Jim Wilson | Third | 1½ out |
| Former Indian Gus Dorner dies in Chambersburg, PA at the age of 80. |
| Saturday, May 5 |
| » Defeated Orioles (6-11), 2-1 | Memorial Stadium (2-1) | 9-6 | |
| » Starters: Bob Lemon vs Don Ferrarese | Second | 1½ out |
| Monday, May 7 |
| » Lost to Red Sox (8-7), 5-1 | Fenway Park (0-1) | 9-7 | |
| » Starters: Mike Garcia vs Tom Brewer | Second | 3 out |
| Tuesday, May 8 |
| » Lost to Yankees (14-5), 4-3 | Yankee Stadium (0-1) | 9-8 | Lost 2 |
| » Starters: Early Wynn vs Johnny Kucks | Third | 4 out |
| Wednesday, May 9 |
| » Defeated Yankees (14-6), 6-5 | Yankee Stadium (1-1) | 10-8 | |
| » Starters: Herb Score vs Don Larsen | Third | 3 out |
| Thursday, May 10 |
| » Defeated Yankees (14-7), 7-2 | Yankee Stadium (2-1) | 11-8 | Won 2 |
| » Starters: Bob Lemon vs Mickey McDermott | Second | 2 out |
| Friday, May 11 |
| » Defeated Athletics (8-11), 4-1 | Cleveland Stadium (3-2) | 12-8 | Won 3 |
| » Starters: Lou Kretlow vs Mike Garcia | Second | 2 out |
| Saturday, May 12 |
| » Defeated Athletics (8-12), 5-3 | Cleveland Stadium (4-2) | 13-8 | Won 4 |
| » Starters: Troy Herriage vs Early Wynn | Second | 1 out |
| Sunday, May 13 |
| » Lost to Athletics (9-12), 5-2 | Cleveland Stadium (4-3) | 13-9 | |
| » Starters: Art Ditmar vs Bob Feller | Second | 1 out |
| » Defeated Athletics (9-13), 9-4 | Cleveland Stadium (5-3) | 14-9 | |
| » Starters: Tom Lasorda vs Herb Score | Second | 1 out |
| Monday, May 14 |
| » Defeated Yankees (16-10), 3-2 | Cleveland Stadium (6-3) | 15-9 | Won 2 |
| » Starters: Johnny Kucks vs Bob Lemon | First | -- |
| Wednesday, May 16 |
| » Lost to Yankees (17-10), 4-1 | Cleveland Stadium (6-4) | 15-10 | |
| » Starters: Mickey McDermott vs Mike Garcia | Second | 1 out |
| Friday, May 18 |
| » Lost to Senators (12-15), 5-4 | Cleveland Stadium (6-5) | 15-11 | Lost 2 |
| » Starters: Dean Stone vs Early Wynn | Second | 2½ out |
| Saturday, May 19 |
| » Defeated Senators (12-16), 5-1 | Cleveland Stadium (7-5) | 16-11 | |
| » Starters: Camilo Pascual vs Herb Score | Second | 2½ out |
| Sunday, May 20 |
| » Defeated Orioles (15-16), 6-1 | Cleveland Stadium (8-5) | 17-11 | Won 2 |
| » Starters: Jim Wilson vs Bob Lemon | Second | 2 out |
| » Defeated Orioles (15-17), 5-1 | Cleveland Stadium (9-5) | 18-11 | Won 3 |
| » Starters: Erv Palica vs Mike Garcia | Second | 2 out |
| Tuesday, May 22 |
| » Lost to Red Sox (17-12), 5-3 | Cleveland Stadium (9-6) | 18-12 | |
| » Starters: Tom Brewer vs Early Wynn | Second | 2½ out |
| Wednesday, May 23 |
| » Defeated Red Sox (17-13), 6-3 | Cleveland Stadium (10-6) | 19-12 | |
| » Starters: Frank Sullivan vs Herb Score | Second | 2½ out |
| Friday, May 25 |
| » Lost to White Sox (14-13), 2-1 | Comiskey Park I (0-3) | 19-13 | |
| » Starters: Mike Garcia vs Billy Pierce | Second | 4 out |
| Sunday, May 27 |
| » Lost to White Sox (15-13), 5-4 | Comiskey Park I (0-4) | 19-14 | Lost 2 |
| » Starters: Bob Lemon vs Bob Keegan | Second | 3½ out |
| » Defeated White Sox (15-14), 4-2 | Comiskey Park I (1-4) | 20-14 | |
| » Starters: Early Wynn vs Jack Harshman | Second | 3½ out |
| Future Indian Bud Anderson is born in Westbury, NY. |
| Monday, May 28 |
| » Lost to Tigers (16-21), 3-1 | Cleveland Stadium (10-7) | 20-15 | |
| » Starters: Steve Gromek vs Herb Score | Second | 4½ out |
| Wednesday, May 30 |
| » Lost to White Sox (17-15), 6-3 | Cleveland Stadium (10-8) | 20-16 | Lost 2 |
| » Starters: Billy Pierce vs Art Houtteman | Third | 6 out |
| » Lost to White Sox (18-15), 9-8 | Cleveland Stadium (10-9) | 20-17 | Lost 3 |
| » Starters: Gerry Staley vs Mike Garcia | Third | 6 out |
| Friday, June 1 |
| » Lost to Senators (17-25), 5-3 | Griffith Stadium (1-1) | 20-18 | Lost 4 |
| » Starters: Bob Lemon vs Bob Wiesler | Third | 6½ out |
| Saturday, June 2 |
| » Defeated Senators (17-26), 15-0 | Griffith Stadium (2-1) | 21-18 | |
| » Starters: Herb Score vs Dean Stone | Second | 6 out |
| Sunday, June 3 |
| » Defeated Senators (17-27), 8-4 | Griffith Stadium (3-1) | 22-18 | Won 2 |
| » Starters: Early Wynn vs Camilo Pascual | Third | 5 out |
| » Lost to Senators (18-27), 7-1 | Griffith Stadium (3-2) | 22-19 | |
| » Starters: Don Mossi vs Hal Griggs | Third | 5 out |
| Former Indian Roxy Walters dies in Alameda, CA at the age of 64. |
| Monday, June 4 |
| » Defeated Senators (18-28), 7-0 | Griffith Stadium (4-2) | 23-19 | |
| » Starters: Mike Garcia vs Pedro Ramos | Third | 4½ out |
| Tuesday, June 5 |
| » Defeated Orioles (20-25), 8-3 | Memorial Stadium (3-1) | 24-19 | Won 2 |
| » Starters: Bob Lemon vs Ray Moore | Second | 3½ out |
| Wednesday, June 6 |
| » Defeated Orioles (20-26), 5-1 | Memorial Stadium (4-1) | 25-19 | Won 3 |
| » Starters: Art Houtteman vs Connie Johnson | Second | 3½ out |
| Thursday, June 7 |
| » Lost to Orioles (21-26), 5-2 | Memorial Stadium (4-2) | 25-20 | |
| » Starters: Cal McLish vs Bill Wight | Second | 4½ out |
| Friday, June 8 |
| » Defeated Yankees (31-18), 9-0 | Yankee Stadium (3-1) | 26-20 | |
| » Starters: Early Wynn vs Whitey Ford | Second | 3½ out |
| Saturday, June 9 |
| » Defeated Yankees (31-19), 15-8 | Yankee Stadium (4-1) | 27-20 | Won 2 |
| » Starters: Mike Garcia vs Don Larsen | Second | 2½ out |
| Sunday, June 10 |
| » Lost to Yankees (32-19), 6-0 | Yankee Stadium (4-2) | 27-21 | |
| » Starters: Bob Lemon vs Johnny Kucks | Second | 3½ out |
| Monday, June 11 |
| » Defeated Red Sox (24-25), 4-1 | Fenway Park (1-1) | 28-21 | |
| » Starters: Cal McLish vs Bob Porterfield | Second | 3½ out |
| » Lost to Red Sox (25-25), 5-1 | Fenway Park (1-2) | 28-22 | |
| » Starters: Mike Garcia vs Tom Brewer | Second | 3½ out |
| Tuesday, June 12 |
| » Lost to Red Sox (26-25), 9-7 | Fenway Park (1-3) | 28-23 | Lost 2 |
| » Starters: Early Wynn vs Frank Sullivan | Second | 4½ out |
| Wednesday, June 13 |
| » Tied Red Sox, 8-8 | Fenway Park (1-3) | 28-23 | |
| » Starters: Don Mossi vs Willard Nixon | Third | 4 out |
| Thursday, June 14 |
| » Lost to Red Sox (27-25), 10-9 | Fenway Park (1-4) | 28-24 | Lost 3 |
| » Starters: Bob Lemon vs Ike Delock | Third | 5 out |
| Friday, June 15 |
| » Lost to Yankees (35-20), 6-2 | Cleveland Stadium (10-10) | 28-25 | Lost 4 |
| » Starters: Johnny Kucks vs Mike Garcia | Third | 6 out |
| » Major-league debuts: Norm Siebern (Yankees) |
| Future Indian Lance Parrish is born in Clairton, PA. |
| Saturday, June 16 |
| » Lost to Yankees (36-20), 3-1 | Cleveland Stadium (10-11) | 28-26 | Lost 5 |
| » Starters: Tom Sturdivant vs Herb Score | Third | 7 out |
| Sunday, June 17 |
| » Lost to Yankees (37-20), 9-4 | Cleveland Stadium (10-12) | 28-27 | Lost 6 |
| » Starters: Whitey Ford vs Early Wynn | Fourth | 8 out |
| Tuesday, June 19 |
| » Defeated Red Sox (29-27), 9-7 | Cleveland Stadium (11-12) | 29-27 | |
| » Starters: Ike Delock vs Bob Lemon | Third | 8½ out |
| Wednesday, June 20 |
| » Defeated Red Sox (29-28), 5-4 | Cleveland Stadium (12-12) | 30-27 | Won 2 |
| » Starters: Bob Porterfield vs Herb Score | Third | 8½ out |
| Thursday, June 21 |
| » Defeated Red Sox (29-29), 5-0 | Cleveland Stadium (13-12) | 31-27 | Won 3 |
| » Starters: Tom Brewer vs Early Wynn | Third | 8 out |
| Future Indian Rick Sutcliffe is born in Independence, MO. |
| Friday, June 22 |
| » Defeated Senators (26-40), 4-0 | Cleveland Stadium (14-12) | 32-27 | Won 4 |
| » Starters: Chuck Stobbs vs Mike Garcia | Third | 7 out |
| Saturday, June 23 |
| » Defeated Senators (26-41), 9-8 | Cleveland Stadium (15-12) | 33-27 | Won 5 |
| » Starters: Hal Griggs vs Art Houtteman | Third | 6 out |
| Sunday, June 24 |
| » Defeated Senators (26-42), 7-2 | Cleveland Stadium (16-12) | 34-27 | Won 6 |
| » Starters: Bob Wiesler vs Bob Lemon | Third | 4½ out |
| Future Indian George Vukovich is born in Chicago, IL. |
| Tuesday, June 26 |
| » Defeated Orioles (31-34), 4-3 | Cleveland Stadium (17-12) | 35-27 | Won 7 |
| » Starters: Connie Johnson vs Early Wynn | Third | 5 out |
| Wednesday, June 27 |
| » Defeated Orioles (31-35), 12-11 | Cleveland Stadium (18-12) | 36-27 | Won 8 |
| » Starters: Bill Wight vs Mike Garcia | Third | 5 out |
| Friday, June 29 |
| » Defeated White Sox (37-24), 5-2 | Cleveland Stadium (19-12) | 37-27 | Won 9 |
| » Starters: Jim Wilson vs Herb Score | Third | 5½ out |
| » Lost to White Sox (38-24), 13-2 | Cleveland Stadium (19-13) | 37-28 | |
| » Starters: Billy Pierce vs Bob Lemon | Third | 5½ out |
| Saturday, June 30 |
| » Lost to White Sox (39-24), 8-3 | Cleveland Stadium (19-14) | 37-29 | Lost 2 |
| » Starters: Gerry Staley vs Don Mossi | Third | 5½ out |
| Sunday, July 1 |
| » Defeated White Sox (39-25), 7-6 | Cleveland Stadium (20-14) | 38-29 | |
| » Starters: Jack Harshman vs Early Wynn | Third | 5½ out |
| » Defeated White Sox (39-26), 6-1 | Cleveland Stadium (21-14) | 39-29 | Won 2 |
| » Starters: Dick Donovan vs Bob Lemon | Third | 5½ out |
| Monday, July 2 |
| Former Indian Roy Wilkinson dies in Louisville, KY at the age of 64. |
| Tuesday, July 3 |
| » Defeated Athletics (26-45), 9-3 | Cleveland Stadium (22-14) | 40-29 | Won 3 |
| » Starters: Art Ditmar vs Mike Garcia | Third | 5½ out |
| Wednesday, July 4 |
| » Defeated Tigers (30-40), 6-4 | Tiger Stadium (3-1) | 41-29 | Won 4 |
| » Starters: Herb Score vs Paul Foytack | Third | 4½ out |
| » Defeated Tigers (30-41), 3-1 | Tiger Stadium (4-1) | 42-29 | Won 5 |
| » Starters: Early Wynn vs Duke Maas | Third | 4½ out |
| Thursday, July 5 |
| » Lost to Tigers (31-41), 13-7 | Tiger Stadium (4-2) | 42-30 | |
| » Starters: Bob Lemon vs Frank Lary | Third | 5½ out |
| Friday, July 6 |
| » Defeated Athletics (27-47), 4-2 | Municipal Stadium (3-0) | 43-30 | |
| » Starters: Mike Garcia vs Troy Herriage | Third | 5½ out |
| Saturday, July 7 |
| » Lost to Athletics (28-47), 5-2 | Municipal Stadium (3-1) | 43-31 | |
| » Starters: Herb Score vs Art Ditmar | Third | 6½ out |
| Sunday, July 8 |
| » Defeated Athletics (28-48), 17-3 | Municipal Stadium (4-1) | 44-31 | |
| » Starters: Early Wynn vs Jack McMahan | Third | 6½ out |
| Thursday, July 12 |
| » Lost to Yankees (53-26), 9-5 | Yankee Stadium (4-3) | 44-32 | |
| » Starters: Bob Lemon vs Johnny Kucks | Third | 7½ out |
| Future Indian Bryan Clark is born in Madera, CA. |
| Friday, July 13 |
| » Lost to Yankees (54-26), 10-0 | Yankee Stadium (4-4) | 44-33 | Lost 2 |
| » Starters: Early Wynn vs Tom Sturdivant | Third | 8½ out |
| Former Indian Glenn Liebhardt dies in Cleveland, OH at the age of 74. |
| Saturday, July 14 |
| » Lost to Yankees (55-26), 5-4 | Yankee Stadium (4-5) | 44-34 | Lost 3 |
| » Starters: Herb Score vs Don Larsen | Third | 9½ out |
| Sunday, July 15 |
| » Defeated Red Sox (43-36), 10-7 | Fenway Park (2-4) | 45-34 | |
| » Starters: Hank Aguirre vs Willard Nixon | Second | 10½ out |
| » Lost to Red Sox (44-36), 3-1 | Fenway Park (2-5) | 45-35 | |
| » Starters: Mike Garcia vs Dave Sisler | Second | 10½ out |
| Monday, July 16 |
| » Defeated Red Sox (44-37), 7-3 | Fenway Park (3-5) | 46-35 | |
| » Starters: Bob Lemon vs Frank Sullivan | Second | 10 out |
| Wednesday, July 18 |
| » Lost to Senators (34-53), 7-5 | Griffith Stadium (4-3) | 46-36 | |
| » Starters: Herb Score vs Bob Wiesler | Second | 9½ out |
| » Defeated Senators (34-54), 11-1 | Griffith Stadium (5-3) | 47-36 | |
| » Starters: Early Wynn vs Camilo Pascual | Second | 9½ out |
| Thursday, July 19 |
| » Lost to Senators (35-54), 5-4 | Griffith Stadium (5-4) | 47-37 | |
| » Starters: Mike Garcia vs Hal Griggs | Second | 10½ out |
| Saturday, July 21 |
| » Defeated Orioles (40-46), 4-3 | Memorial Stadium (5-2) | 48-37 | |
| » Starters: Bob Lemon vs Ray Moore | Second | 10 out |
| » Defeated Orioles (40-47), 4-3 | Memorial Stadium (6-2) | 49-37 | Won 2 |
| » Starters: Herb Score vs Hal Brown | Second | 10 out |
| Sunday, July 22 |
| » Defeated Orioles (40-48), 8-0 | Memorial Stadium (7-2) | 50-37 | Won 3 |
| » Starters: Early Wynn vs Bill Wight | Second | 9½ out |
| Tuesday, July 24 |
| » Defeated Senators (36-56), 11-0 | Cleveland Stadium (23-14) | 51-37 | Won 4 |
| » Starters: Bunky Stewart vs Mike Garcia | Second | 8½ out |
| Wednesday, July 25 |
| » Defeated Senators (36-57), 11-3 | Cleveland Stadium (24-14) | 52-37 | Won 5 |
| » Starters: Camilo Pascual vs Herb Score | Second | 8½ out |
| Thursday, July 26 |
| » Defeated Senators (36-58), 1-0 | Cleveland Stadium (25-14) | 53-37 | Won 6 |
| » Starters: Chuck Stobbs vs Bob Lemon | Second | 8½ out |
| Friday, July 27 |
| » Defeated Orioles (42-51), 3-2 | Cleveland Stadium (26-14) | 54-37 | Won 7 |
| » Starters: Johnny Schmitz vs Early Wynn | Second | 8½ out |
| Saturday, July 28 |
| » Lost to Orioles (43-51), 8-6 | Cleveland Stadium (26-15) | 54-38 | |
| » Starters: Connie Johnson vs Mike Garcia | Second | 9½ out |
| Sunday, July 29 |
| » Defeated Orioles (43-52), 3-0 | Cleveland Stadium (27-15) | 55-38 | |
| » Starters: Erv Palica vs Herb Score | Second | 9 out |
| » Defeated Orioles (43-53), 4-0 | Cleveland Stadium (28-15) | 56-38 | Won 2 |
| » Starters: Don Ferrarese vs Hank Aguirre | Second | 9 out |
| Monday, July 30 |
| » Lost to Yankees (67-30), 13-6 | Cleveland Stadium (28-16) | 56-39 | |
| » Starters: Whitey Ford vs Bob Lemon | Second | 10 out |
| Tuesday, July 31 |
| » Defeated Yankees (67-31), 5-0 | Cleveland Stadium (29-16) | 57-39 | |
| » Starters: Johnny Kucks vs Early Wynn | Second | 9 out |
| Wednesday, August 1 |
| » Defeated Yankees (67-32), 5-1 | Cleveland Stadium (30-16) | 58-39 | Won 2 |
| » Starters: Tommy Byrne vs Bob Lemon | Second | 8 out |
| Thursday, August 2 |
| » Defeated Yankees (67-33), 4-0 | Cleveland Stadium (31-16) | 59-39 | Won 3 |
| » Starters: Tom Sturdivant vs Herb Score | Second | 7 out |
| Friday, August 3 |
| » Lost to Red Sox (56-44), 7-1 | Cleveland Stadium (31-17) | 59-40 | |
| » Starters: Mel Parnell vs Mike Garcia | Second | 7 out |
| Saturday, August 4 |
| » Lost to Red Sox (57-44), 6-5 | Cleveland Stadium (31-18) | 59-41 | Lost 2 |
| » Starters: Frank Sullivan vs Early Wynn | Second | 7 out |
| Sunday, August 5 |
| » Lost to Red Sox (58-44), 2-1 | Cleveland Stadium (31-19) | 59-42 | Lost 3 |
| » Starters: Dave Sisler vs Bob Lemon | Second | 7 out |
| Monday, August 6 |
| » Lost to Tigers (49-55), 9-0 | Tiger Stadium (4-3) | 59-43 | Lost 4 |
| » Starters: Herb Score vs Paul Foytack | Second | 8 out |
| Tuesday, August 7 |
| » Defeated Tigers (49-56), 5-2 | Tiger Stadium (5-3) | 60-43 | |
| » Starters: Mike Garcia vs Frank Lary | Second | 7 out |
| Wednesday, August 8 |
| » Lost to White Sox (54-48), 7-6 | Comiskey Park I (1-5) | 60-44 | |
| » Starters: Hank Aguirre vs Billy Pierce | Second | 8 out |
| Thursday, August 9 |
| » Lost to White Sox (55-48), 9-2 | Comiskey Park I (1-6) | 60-45 | Lost 2 |
| » Starters: Early Wynn vs Jack Harshman | Third | 9 out |
| Friday, August 10 |
| » Defeated Athletics (37-70), 11-0 | Municipal Stadium (5-1) | 61-45 | |
| » Starters: Bob Lemon vs Wally Burnette | Third | 9 out |
| Saturday, August 11 |
| » Defeated Athletics (37-71), 8-5 | Municipal Stadium (6-1) | 62-45 | Won 2 |
| » Starters: Mike Garcia vs Jack Crimian | Second | 8 out |
| Sunday, August 12 |
| » Defeated Athletics (37-72), 6-3 | Municipal Stadium (7-1) | 63-45 | Won 3 |
| » Starters: Herb Score vs Lou Kretlow | Second | 8½ out |
| Tuesday, August 14 |
| » Lost to Tigers (53-58), 6-4 | Cleveland Stadium (31-20) | 63-46 | |
| » Starters: Paul Foytack vs Early Wynn | Second | 9½ out |
| Wednesday, August 15 |
| » Lost to Tigers (54-58), 1-0 | Cleveland Stadium (31-21) | 63-47 | Lost 2 |
| » Starters: Frank Lary vs Bob Lemon | Second | 10½ out |
| Thursday, August 16 |
| » Defeated Tigers (54-59), 5-4 | Cleveland Stadium (32-21) | 64-47 | |
| » Starters: Billy Hoeft vs Herb Score | Second | 9½ out |
| Friday, August 17 |
| » Lost to Athletics (38-75), 9-3 | Cleveland Stadium (32-22) | 64-48 | |
| » Starters: Jack Crimian vs Hank Aguirre | Second | 9½ out |
| Saturday, August 18 |
| » Defeated Athletics (38-76), 8-1 | Cleveland Stadium (33-22) | 65-48 | |
| » Starters: Lou Kretlow vs Early Wynn | Second | 10 out |
| Sunday, August 19 |
| » Defeated Athletics (38-77), 5-2 | Cleveland Stadium (34-22) | 66-48 | Won 2 |
| » Starters: Wally Burnette vs Bob Lemon | Second | 8½ out |
| » Defeated Athletics (38-78), 2-1 | Cleveland Stadium (35-22) | 67-48 | Won 3 |
| » Starters: Art Ditmar vs Mike Garcia | Second | 8½ out |
| Tuesday, August 21 |
| » Defeated Yankees (77-42), 3-0 | Yankee Stadium (5-5) | 68-48 | Won 4 |
| » Starters: Herb Score vs Don Larsen | Second | 7½ out |
| Wednesday, August 22 |
| » Lost to Yankees (78-42), 3-2 | Yankee Stadium (5-6) | 68-49 | |
| » Starters: Early Wynn vs Tom Sturdivant | Second | 8½ out |
| Thursday, August 23 |
| » Lost to Red Sox (65-54), 2-1 | Fenway Park (3-6) | 68-50 | Lost 2 |
| » Starters: Bob Lemon vs Mel Parnell | Second | 8 out |
| Friday, August 24 |
| » Defeated Red Sox (65-55), 5-3 | Fenway Park (4-6) | 69-50 | |
| » Starters: Mike Garcia vs Tom Brewer | Second | 8 out |
| Future Indian Tony Bernazard is born in Caguas, P.R. |
| Saturday, August 25 |
| » Lost to Red Sox (66-55), 9-6 | Fenway Park (4-7) | 69-51 | |
| » Starters: Herb Score vs Dave Sisler | Second | 8 out |
| Sunday, August 26 |
| » Defeated Senators (51-70), 4-1 | Griffith Stadium (6-4) | 70-51 | |
| » Starters: Early Wynn vs Dean Stone | Second | 7½ out |
| Monday, August 27 |
| » Defeated Senators (51-71), 5-2 | Griffith Stadium (7-4) | 71-51 | Won 2 |
| » Starters: Bob Lemon vs Hal Griggs | Second | 7 out |
| Tuesday, August 28 |
| » Lost to Orioles (56-68), 1-0 | Memorial Stadium (7-3) | 71-52 | |
| » Starters: Hank Aguirre vs Ray Moore | Second | 8 out |
| Wednesday, August 29 |
| » Defeated Orioles (56-69), 3-2 | Memorial Stadium (8-3) | 72-52 | |
| » Starters: Mike Garcia vs Mike Fornieles | Second | 8 out |
| Friday, August 31 |
| » Defeated White Sox (69-56), 3-2 | Comiskey Park I (2-6) | 73-52 | Won 2 |
| » Starters: Herb Score vs Billy Pierce | Second | 8½ out |
| » Lost to White Sox (70-56), 1-0 | Comiskey Park I (2-7) | 73-53 | |
| » Starters: Early Wynn vs Dick Donovan | Second | 8½ out |
| Saturday, September 1 |
| » Defeated White Sox (70-57), 5-1 | Comiskey Park I (3-7) | 74-53 | |
| » Starters: Bob Lemon vs Gerry Staley | Second | 7½ out |
| Sunday, September 2 |
| » Lost to White Sox (71-57), 4-3 | Comiskey Park I (3-8) | 74-54 | |
| » Starters: Hank Aguirre vs Jack Harshman | Second | 7½ out |
| Monday, September 3 |
| » Lost to Athletics (42-87), 5-2 | Municipal Stadium (7-2) | 74-55 | Lost 2 |
| » Starters: Mike Garcia vs Tom Gorman | Second | 8½ out |
| » Defeated Athletics (42-88), 2-1 | Municipal Stadium (8-2) | 75-55 | |
| » Starters: Early Wynn vs Wally Burnette | Second | 8½ out |
| Tuesday, September 4 |
| » Lost to Athletics (43-88), 5-2 | Municipal Stadium (8-3) | 75-56 | |
| » Starters: Herb Score vs Jack Crimian | Second | 9 out |
| Friday, September 7 |
| » Lost to White Sox (74-58), 2-1 | Cleveland Stadium (35-23) | 75-57 | Lost 2 |
| » Starters: Jack Harshman vs Bob Lemon | Second | 9½ out |
| Saturday, September 8 |
| » Lost to White Sox (75-58), 4-2 | Cleveland Stadium (35-24) | 75-58 | Lost 3 |
| » Starters: Billy Pierce vs Early Wynn | Second | 10½ out |
| Sunday, September 9 |
| » Defeated White Sox (75-59), 4-1 | Cleveland Stadium (36-24) | 76-58 | |
| » Starters: Dick Donovan vs Herb Score | Second | 11 out |
| » Lost to White Sox (76-59), 6-2 | Cleveland Stadium (36-25) | 76-59 | |
| » Starters: Gerry Staley vs Hank Aguirre | Second | 11 out |
| Tuesday, September 11 |
| » Defeated Orioles (59-78), 3-1 | Cleveland Stadium (37-25) | 77-59 | |
| » Starters: Ray Moore vs Bob Lemon | Second | 11 out |
| Wednesday, September 12 |
| » Defeated Orioles (59-79), 2-1 | Cleveland Stadium (38-25) | 78-59 | Won 2 |
| » Starters: Hal Brown vs Early Wynn | Second | 10 out |
| Thursday, September 13 |
| » Lost to Orioles (60-79), 4-1 | Cleveland Stadium (38-26) | 78-60 | |
| » Starters: Connie Johnson vs Hank Aguirre | Second | 11 out |
| Friday, September 14 |
| » Defeated Red Sox (77-63), 10-2 | Cleveland Stadium (39-26) | 79-60 | |
| » Starters: Mel Parnell vs Herb Score | Second | 11½ out |
| » Lost to Red Sox (78-63), 4-3 | Cleveland Stadium (39-27) | 79-61 | |
| » Starters: Dave Sisler vs Mike Garcia | Second | 11½ out |
| Saturday, September 15 |
| » Lost to Red Sox (79-63), 5-3 | Cleveland Stadium (39-28) | 79-62 | Lost 2 |
| » Starters: Rudy Minarcin vs Bob Feller | Second | 11½ out |
| Sunday, September 16 |
| » Lost to Yankees (92-51), 10-3 | Cleveland Stadium (39-29) | 79-63 | Lost 3 |
| » Starters: Tom Sturdivant vs Bob Lemon | Third | 11½ out |
| » Defeated Yankees (92-52), 4-3 | Cleveland Stadium (40-29) | 80-63 | |
| » Starters: Johnny Kucks vs Early Wynn | Third | 11½ out |
| Tuesday, September 18 |
| » Defeated Senators (58-86), 1-0 | Cleveland Stadium (41-29) | 81-63 | Won 2 |
| » Starters: Bob Wiesler vs Herb Score | Second | 11 out |
| » Defeated Senators (58-87), 6-0 | Cleveland Stadium (42-29) | 82-63 | Won 3 |
| » Starters: Chuck Stobbs vs Mike Garcia | Second | 11 out |
| Wednesday, September 19 |
| » Defeated Senators (58-88), 6-0 | Cleveland Stadium (43-29) | 83-63 | Won 4 |
| » Starters: Ted Abernathy vs Bob Lemon | Second | 10½ out |
| Friday, September 21 |
| » Defeated Tigers (77-69), 5-1 | Tiger Stadium (6-3) | 84-63 | Won 5 |
| » Starters: Early Wynn vs Billy Hoeft | Second | 9½ out |
| Saturday, September 22 |
| » Defeated Tigers (77-70), 5-1 | Tiger Stadium (7-3) | 85-63 | Won 6 |
| » Starters: Herb Score vs Paul Foytack | Second | 9½ out |
| Sunday, September 23 |
| » Lost to Tigers (78-70), 11-1 | Tiger Stadium (7-4) | 85-64 | |
| » Starters: Bob Lemon vs Frank Lary | Second | 10½ out |
| Tuesday, September 25 |
| » Defeated Athletics (50-100), 4-1 | Cleveland Stadium (44-29) | 86-64 | |
| » Starters: Wally Burnette vs Early Wynn | Second | 10 out |
| Wednesday, September 26 |
| » Defeated Athletics (50-101), 8-4 | Cleveland Stadium (45-29) | 87-64 | Won 2 |
| » Starters: Art Ditmar vs Herb Score | Second | 9 out |
| Friday, September 28 |
| » Defeated Tigers (80-72), 2-1 | Cleveland Stadium (46-29) | 88-64 | Won 3 |
| » Starters: Billy Hoeft vs Hank Aguirre | Second | 9 out |
| Saturday, September 29 |
| » Lost to Tigers (81-72), 9-1 | Cleveland Stadium (46-30) | 88-65 | |
| » Starters: Frank Lary vs Art Houtteman | Second | 9 out |
| Sunday, September 30 |
| » Lost to Tigers (82-72), 8-4 | Cleveland Stadium (46-31) | 88-66 | Lost 2 |
| » Starters: Ned Garver vs Bob Feller | Second | 9 out |
| Wednesday, December 12 |
| Future Indian Steve Farr is born in LaPlata, MD. |
Game information provided by Retrosheet (www.retrosheet.org) |