| Thursday, March 1 |
| Former Cardinal Ed Heusser dies in Aurora, CO at the age of 47. |
| Saturday, March 24 |
| Future Cardinal Garry Templeton is born in Lockney, TX. |
| Wednesday, April 4 |
| Future Cardinal Tom Herr is born in Lancaster, PA. |
| Wednesday, April 11 |
| Future Cardinal John Martin is born in Wyandotte, MI. |
| Monday, April 16 |
| Former Cardinal George Puccinelli dies in San Francisco, CA at the age of 49. |
| Tuesday, April 17 |
| » Defeated Reds (0-1), 4-2 | Crosley Field (1-0) | 1-0 | |
| » Starters: Vinegar Bend Mizell vs Joe Nuxhall | First | -- |
| » Major-league debuts: Frank Robinson (Reds) |
| Wednesday, April 18 |
| » Major-league debuts: Hal Griggs and Herb Plews (Senators) |
| Thursday, April 19 |
| » Lost to Reds (1-1), 10-9 | Crosley Field (1-1) | 1-1 | |
| » Starters: Harvey Haddix vs Pat Scantlebury | Third | 1 out |
| » Major-league debuts: Pat Scantlebury (Reds) |
| Friday, April 20 |
| » Lost to Braves (3-0), 5-4 | Sportsman's Park III (0-1) | 1-2 | Lost 2 |
| » Starters: Warren Spahn vs Tom Poholsky | Fourth | 2 out |
| » Major-league debuts: Frank Torre (Braves) |
| Saturday, April 21 |
| » Defeated Braves (3-1), 6-5 | Sportsman's Park III (1-1) | 2-2 | |
| » Starters: Red Murff vs Willard Schmidt | Third | 1 out |
| » Major-league debuts: Jackie Brandt (Cardinals) |
| Sunday, April 22 |
| » Defeated Braves (3-2), 10-4 | Sportsman's Park III (2-1) | 3-2 | Won 2 |
| » Starters: Lew Burdette vs Ben Flowers | Third | 1 out |
| » Lost to Braves (4-2), 13-5 | Sportsman's Park III (2-2) | 3-3 | |
| » Starters: Ray Crone vs Gordon Jones | Third | 1 out |
| » Major-league debuts: Bob Trowbridge (Braves) |
| Tuesday, April 24 |
| » Defeated Reds (1-5), 5-3 | Sportsman's Park III (3-2) | 4-3 | |
| » Starters: Pat Scantlebury vs Vinegar Bend Mizell | Third | ½ out |
| Wednesday, April 25 |
| » Defeated Cubs (3-3), 6-0 | Sportsman's Park III (4-2) | 5-3 | Won 2 |
| » Starters: Sam Jones vs Harvey Haddix | Third | ½ out |
| Monday, April 30 |
| » Defeated Braves (4-3), 2-0 | County Stadium (1-0) | 6-3 | Won 3 |
| » Starters: Tom Poholsky vs Warren Spahn | First | -- |
| Tuesday, May 1 |
| » Lost to Pirates (6-6), 4-2 | Sportsman's Park III (4-3) | 6-4 | |
| » Starters: Dick Littlefield vs Vinegar Bend Mizell | Second | 1 out |
| Wednesday, May 2 |
| » Defeated Pirates (6-7), 10-9 | Sportsman's Park III (5-3) | 7-4 | |
| » Starters: Ron Kline vs Harvey Haddix | First | -- |
| » Major-league debuts: Hal Smith (Cardinals) |
| Thursday, May 3 |
| » Lost to Dodgers (8-6), 7-3 | Sportsman's Park III (5-4) | 7-5 | |
| » Starters: Don Newcombe vs Ben Flowers | Second | 2 out |
| Friday, May 4 |
| » Defeated Dodgers (8-7), 10-3 | Sportsman's Park III (6-4) | 8-5 | |
| » Starters: Chuck Templeton vs Willard Schmidt | Second | 2 out |
| Future Cardinal Ken Oberkfell is born in Highland, IL. |
| Saturday, May 5 |
| » Defeated Dodgers (8-8), 4-1 | Sportsman's Park III (7-4) | 9-5 | Won 2 |
| » Starters: Roger Craig vs Tom Poholsky | Second | 2½ out |
| Sunday, May 6 |
| » Defeated Giants (7-8), 5-4 | Sportsman's Park III (8-4) | 10-5 | Won 3 |
| » Starters: Don Liddle vs Harvey Haddix | Third | 3½ out |
| » Lost to Giants (8-8), 5-4 | Sportsman's Park III (8-5) | 10-6 | |
| » Starters: Joe Margoneri vs Vinegar Bend Mizell | Third | 3½ out |
| Monday, May 7 |
| » Defeated Giants (8-9), 6-3 | Sportsman's Park III (9-5) | 11-6 | |
| » Starters: Windy McCall vs Ben Flowers | Second | 3½ out |
| » Major-league debuts: Bill White (Giants) |
| Tuesday, May 8 |
| » Defeated Phillies (5-11), 9-1 | Sportsman's Park III (10-5) | 12-6 | Won 2 |
| » Starters: Robin Roberts vs Willard Schmidt | Second | 3½ out |
| Wednesday, May 9 |
| » Defeated Phillies (5-12), 3-0 | Sportsman's Park III (11-5) | 13-6 | Won 3 |
| » Starters: Herm Wehmeier vs Tom Poholsky | Second | 4 out |
| Saturday, May 12 |
| » Lost to Cubs (5-11), 14-10 | Wrigley Field (0-1) | 13-7 | |
| » Starters: Vinegar Bend Mizell vs Bob Rush | Second | 3½ out |
| Sunday, May 13 |
| » Defeated Cubs (5-12), 3-2 | Wrigley Field (1-1) | 14-7 | |
| » Starters: Murry Dickson vs Paul Minner | Second | 3½ out |
| » Defeated Cubs (5-13), 14-7 | Wrigley Field (2-1) | 15-7 | Won 2 |
| » Starters: Lindy McDaniel vs Sam Jones | Second | 3½ out |
| Tuesday, May 15 |
| » Lost to Dodgers (13-9), 7-5 | Ebbets Field (0-1) | 15-8 | |
| » Starters: Tom Poholsky vs Chuck Templeton | Second | 3½ out |
| Wednesday, May 16 |
| » Lost to Dodgers (14-9), 5-3 | Roosevelt Stadium (0-1) | 15-9 | Lost 2 |
| » Starters: Herm Wehmeier vs Roger Craig | Second | 3½ out |
| Thursday, May 17 |
| » Defeated Phillies (8-16), 5-4 | Shibe Park (1-0) | 16-9 | |
| » Starters: Vinegar Bend Mizell vs Harvey Haddix | Second | 3½ out |
| Friday, May 18 |
| » Lost to Phillies (9-16), 4-2 | Shibe Park (1-1) | 16-10 | |
| » Starters: Willard Schmidt vs Curt Simmons | Second | 4 out |
| Saturday, May 19 |
| » Defeated Phillies (9-17), 11-5 | Shibe Park (2-1) | 17-10 | |
| » Starters: Murry Dickson vs Saul Rogovin | Second | 4 out |
| Sunday, May 20 |
| » Lost to Giants (12-15), 2-0 | Polo Grounds V (0-1) | 17-11 | |
| » Starters: Dick Littlefield vs Johnny Antonelli | Third | 4 out |
| » Lost to Giants (13-15), 5-2 | Polo Grounds V (0-2) | 17-12 | Lost 2 |
| » Starters: Tom Poholsky vs Jim Hearn | Third | 4 out |
| Monday, May 21 |
| » Defeated Giants (13-16), 4-1 | Polo Grounds V (1-2) | 18-12 | |
| » Starters: Vinegar Bend Mizell vs Don Liddle | Second | 4½ out |
| Tuesday, May 22 |
| » Defeated Pirates (15-14), 6-3 | Forbes Field (1-0) | 19-12 | Won 2 |
| » Starters: Herm Wehmeier vs Vern Law | Second | 4½ out |
| Wednesday, May 23 |
| » Lost to Pirates (16-14), 6-0 | Forbes Field (1-1) | 19-13 | |
| » Starters: Willard Schmidt vs Bob Friend | Second | 5 out |
| Friday, May 25 |
| » Defeated Cubs (8-19), 6-1 | Sportsman's Park III (12-5) | 20-13 | |
| » Starters: Russ Meyer vs Murry Dickson | Second | 5 out |
| Sunday, May 27 |
| » Defeated Cubs (8-20), 11-9 | Sportsman's Park III (13-5) | 21-13 | Won 2 |
| » Starters: Paul Minner vs Tom Poholsky | Second | 5 out |
| » Defeated Cubs (8-21), 12-2 | Sportsman's Park III (14-5) | 22-13 | Won 3 |
| » Starters: Jim Brosnan vs Vinegar Bend Mizell | Second | 5 out |
| Monday, May 28 |
| » Lost to Braves (17-9), 10-3 | Sportsman's Park III (14-6) | 22-14 | |
| » Starters: Lou Sleater vs Herm Wehmeier | Second | 5 out |
| Wednesday, May 30 |
| » Lost to Reds (20-15), 6-3 | Sportsman's Park III (14-7) | 22-15 | Lost 2 |
| » Starters: Johnny Klippstein vs Murry Dickson | Third | 5 out |
| » Lost to Reds (21-15), 6-5 | Sportsman's Park III (14-8) | 22-16 | Lost 3 |
| » Starters: Paul LaPalme vs Dick Littlefield | Third | 5 out |
| Thursday, May 31 |
| » Defeated Reds (21-16), 9-3 | Sportsman's Park III (15-8) | 23-16 | |
| » Starters: Art Fowler vs Vinegar Bend Mizell | Second | 5 out |
| Friday, June 1 |
| » Lost to Phillies (14-22), 5-2 | Sportsman's Park III (15-9) | 23-17 | |
| » Starters: Curt Simmons vs Tom Poholsky | Third | 5 out |
| Saturday, June 2 |
| » Lost to Phillies (15-22), 6-4 | Sportsman's Park III (15-10) | 23-18 | Lost 2 |
| » Starters: Stu Miller vs Herm Wehmeier | Fourth | 5 out |
| Sunday, June 3 |
| » Defeated Phillies (15-23), 2-1 | Sportsman's Park III (16-10) | 24-18 | |
| » Starters: Robin Roberts vs Murry Dickson | Fourth | 5 out |
| » Lost to Phillies (16-23), 9-3 | Sportsman's Park III (16-11) | 24-19 | |
| » Starters: Harvey Haddix vs Lindy McDaniel | Fourth | 5 out |
| Monday, June 4 |
| » Defeated Giants (17-24), 11-5 | Sportsman's Park III (17-11) | 25-19 | |
| » Starters: Don Liddle vs Vinegar Bend Mizell | Fourth | 5 out |
| Future Cardinal Terry Kennedy is born in Euclid, OH. |
| Tuesday, June 5 |
| » Defeated Giants (17-25), 3-1 | Sportsman's Park III (18-11) | 26-19 | Won 2 |
| » Starters: Jim Hearn vs Willard Schmidt | Second | 1 out |
| Wednesday, June 6 |
| » Defeated Giants (17-26), 3-2 | Sportsman's Park III (19-11) | 27-19 | Won 3 |
| » Starters: Ruben Gomez vs Tom Poholsky | Second | 1 out |
| Friday, June 8 |
| » Lost to Pirates (26-19), 2-0 | Sportsman's Park III (19-12) | 27-20 | |
| » Starters: Bob Friend vs Murry Dickson | Third | 1½ out |
| Saturday, June 9 |
| » Defeated Pirates (26-20), 8-3 | Sportsman's Park III (20-12) | 28-20 | |
| » Starters: Vern Law vs Vinegar Bend Mizell | Second | ½ out |
| Future Cardinal John Fulgham is born in St. Louis, MO. |
| Sunday, June 10 |
| » Lost to Pirates (27-20), 11-3 | Sportsman's Park III (20-13) | 28-21 | |
| » Starters: Luis Arroyo vs Willard Schmidt | Second | 1 out |
| » Defeated Pirates (27-21), 3-0 | Sportsman's Park III (21-13) | 29-21 | |
| » Starters: Ron Kline vs Herm Wehmeier | Second | 1 out |
| Monday, June 11 |
| » Lost to Dodgers (26-21), 8-6 | Sportsman's Park III (21-14) | 29-22 | |
| » Starters: Don Newcombe vs Tom Poholsky | Second | 1½ out |
| Tuesday, June 12 |
| » Lost to Dodgers (27-21), 6-4 | Sportsman's Park III (21-15) | 29-23 | Lost 2 |
| » Starters: Sandy Koufax vs Murry Dickson | Third | 1½ out |
| Friday, June 15 |
| » Lost to Pirates (29-21), 12-1 | Forbes Field (1-2) | 29-24 | Lost 3 |
| » Starters: Vinegar Bend Mizell vs Ron Kline | Fourth | 1½ out |
| Saturday, June 16 |
| » Lost to Pirates (30-21), 2-0 | Forbes Field (1-3) | 29-25 | Lost 4 |
| » Starters: Herm Wehmeier vs Bob Friend | Fourth | 2½ out |
| Sunday, June 17 |
| » Defeated Pirates (30-22), 3-1 | Forbes Field (2-3) | 30-25 | |
| » Starters: Tom Poholsky vs Vern Law | Third | 1½ out |
| » Defeated Pirates (30-23), 8-3 | Forbes Field (3-3) | 31-25 | Won 2 |
| » Starters: Willard Schmidt vs Luis Arroyo | Third | 1½ out |
| Tuesday, June 19 |
| » Defeated Dodgers (29-24), 6-0 | Ebbets Field (1-1) | 32-25 | Won 3 |
| » Starters: Murry Dickson vs Sandy Koufax | Second | 1 out |
| Wednesday, June 20 |
| » Lost to Dodgers (30-24), 4-2 | Ebbets Field (1-2) | 32-26 | |
| » Starters: Vinegar Bend Mizell vs Roger Craig | Fourth | 3½ out |
| Thursday, June 21 |
| » Lost to Dodgers (31-24), 9-8 | Ebbets Field (1-3) | 32-27 | Lost 2 |
| » Starters: Herm Wehmeier vs Don Newcombe | Fourth | 3½ out |
| Future Cardinal Rick Sutcliffe is born in Independence, MO. |
| Friday, June 22 |
| » Lost to Phillies (24-34), 2-1 | Shibe Park (2-2) | 32-28 | Lost 3 |
| » Starters: Tom Poholsky vs Robin Roberts | Fourth | 3½ out |
| Saturday, June 23 |
| » Lost to Phillies (25-34), 8-3 | Shibe Park (2-3) | 32-29 | Lost 4 |
| » Starters: Don Liddle vs Harvey Haddix | Fourth | 3½ out |
| Sunday, June 24 |
| » Defeated Phillies (25-35), 8-4 | Shibe Park (3-3) | 33-29 | |
| » Starters: Murry Dickson vs Curt Simmons | Fourth | 4½ out |
| » Lost to Phillies (26-35), 3-2 | Shibe Park (3-4) | 33-30 | |
| » Starters: Willard Schmidt vs Jim Owens | Fourth | 4½ out |
| Tuesday, June 26 |
| » Lost to Giants (24-36), 3-0 | Polo Grounds V (1-3) | 33-31 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Ruben Gomez | Fourth | 5 out |
| Wednesday, June 27 |
| » Defeated Giants (24-37), 6-0 | Polo Grounds V (2-3) | 34-31 | |
| » Starters: Tom Poholsky vs Johnny Antonelli | Fourth | 4 out |
| Friday, June 29 |
| » Defeated Reds (37-27), 4-1 | Sportsman's Park III (22-15) | 35-31 | Won 2 |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Fourth | 3 out |
| Future Cardinal Pedro Guerrero is born in San Pedro de Macoris, D.R. |
| Saturday, June 30 |
| » Defeated Reds (37-28), 5-2 | Sportsman's Park III (23-15) | 36-31 | Won 3 |
| » Starters: Hal Jeffcoat vs Murry Dickson | Third | 3 out |
| Sunday, July 1 |
| » Lost to Reds (38-28), 19-15 | Sportsman's Park III (23-16) | 36-32 | |
| » Starters: Brooks Lawrence vs Willard Schmidt | Fourth | 4 out |
| » Lost to Reds (39-28), 7-1 | Sportsman's Park III (23-17) | 36-33 | Lost 2 |
| » Starters: Don Gross vs Don Liddle | Fourth | 4 out |
| Monday, July 2 |
| » Lost to Cubs (27-37), 6-3 | Wrigley Field (2-2) | 36-34 | Lost 3 |
| » Starters: Tom Poholsky vs Warren Hacker | Fourth | 5 out |
| Tuesday, July 3 |
| » Lost to Cubs (28-37), 7-4 | Wrigley Field (2-3) | 36-35 | Lost 4 |
| » Starters: Vinegar Bend Mizell vs Jim Davis | Fourth | 5 out |
| Wednesday, July 4 |
| » Defeated Braves (38-28), 6-4 | County Stadium (2-0) | 37-35 | |
| » Starters: Murry Dickson vs Gene Conley | Fourth | 5 out |
| » Lost to Braves (39-28), 6-1 | County Stadium (2-1) | 37-36 | |
| » Starters: Lindy McDaniel vs Bob Buhl | Fourth | 5 out |
| Friday, July 6 |
| » Lost to Reds (42-30), 6-4 | Crosley Field (1-2) | 37-37 | Lost 2 |
| » Starters: Tom Poholsky vs Don Gross | Fourth | 6 out |
| Saturday, July 7 |
| » Lost to Reds (43-30), 5-2 | Crosley Field (1-3) | 37-38 | Lost 3 |
| » Starters: Vinegar Bend Mizell vs Johnny Klippstein | Fourth | 7 out |
| Sunday, July 8 |
| » Lost to Reds (44-30), 3-2 | Crosley Field (1-4) | 37-39 | Lost 4 |
| » Starters: Willard Schmidt vs Joe Nuxhall | Fourth | 8 out |
| Thursday, July 12 |
| » Defeated Giants (31-42), 5-3 | Sportsman's Park III (24-17) | 38-39 | |
| » Starters: Ruben Gomez vs Tom Poholsky | Fourth | 7 out |
| Friday, July 13 |
| » Defeated Giants (31-43), 7-5 | Sportsman's Park III (25-17) | 39-39 | Won 2 |
| » Starters: Johnny Antonelli vs Murry Dickson | Fourth | 7 out |
| Saturday, July 14 |
| » Defeated Giants (31-44), 5-2 | Sportsman's Park III (26-17) | 40-39 | Won 3 |
| » Starters: Al Worthington vs Vinegar Bend Mizell | Fourth | 7 out |
| Sunday, July 15 |
| » Defeated Phillies (35-44), 9-1 | Sportsman's Park III (27-17) | 41-39 | Won 4 |
| » Starters: Stu Miller vs Murry Dickson | Fourth | 8 out |
| » Lost to Phillies (36-44), 7-5 | Sportsman's Park III (27-18) | 41-40 | |
| » Starters: Saul Rogovin vs Lindy McDaniel | Fourth | 8 out |
| Monday, July 16 |
| » Lost to Phillies (37-44), 2-0 | Sportsman's Park III (27-19) | 41-41 | Lost 2 |
| » Starters: Harvey Haddix vs Willard Schmidt | Fourth | 9 out |
| Tuesday, July 17 |
| » Lost to Pirates (38-44), 4-2 | Sportsman's Park III (27-20) | 41-42 | Lost 3 |
| » Starters: Bob Friend vs Herm Wehmeier | Fourth | 9 out |
| Wednesday, July 18 |
| » Tied Pirates, 1-1 | Sportsman's Park III (27-20) | 41-42 | |
| » Starters: Red Munger vs Vinegar Bend Mizell | Fourth | 9½ out |
| Friday, July 20 |
| » Lost to Dodgers (46-38), 4-1 | Sportsman's Park III (27-21) | 41-43 | Lost 4 |
| » Starters: Don Newcombe vs Tom Poholsky | Fourth | 11 out |
| Saturday, July 21 |
| » Defeated Dodgers (46-39), 13-6 | Sportsman's Park III (28-21) | 42-43 | |
| » Starters: Roger Craig vs Murry Dickson | Fourth | 10 out |
| Sunday, July 22 |
| » Lost to Dodgers (47-39), 5-3 | Sportsman's Park III (28-22) | 42-44 | |
| » Starters: Carl Erskine vs Bob Blaylock | Fourth | 12 out |
| » Lost to Dodgers (48-39), 4-3 | Sportsman's Park III (28-23) | 42-45 | Lost 2 |
| » Starters: Sandy Koufax vs Willard Schmidt | Fourth | 12 out |
| Tuesday, July 24 |
| » Lost to Phillies (41-49), 7-3 | Shibe Park (3-5) | 42-46 | Lost 3 |
| » Starters: Vinegar Bend Mizell vs Curt Simmons | Fourth | 13 out |
| Wednesday, July 25 |
| » Defeated Phillies (41-50), 8-7 | Shibe Park (4-5) | 43-46 | |
| » Starters: Murry Dickson vs Harvey Haddix | Fourth | 13 out |
| Thursday, July 26 |
| » Defeated Phillies (41-51), 14-9 | Shibe Park (5-5) | 44-46 | Won 2 |
| » Starters: Bob Blaylock vs Robin Roberts | Fourth | 13 out |
| Friday, July 27 |
| » Lost to Giants (33-55), 6-5 | Polo Grounds V (2-4) | 44-47 | |
| » Starters: Willard Schmidt vs Joe Margoneri | Fourth | 13 out |
| Saturday, July 28 |
| » Defeated Giants (33-56), 3-2 | Polo Grounds V (3-4) | 45-47 | |
| » Starters: Vinegar Bend Mizell vs Ruben Gomez | Fourth | 12½ out |
| Sunday, July 29 |
| » Defeated Giants (33-57), 3-2 | Polo Grounds V (4-4) | 46-47 | Won 2 |
| » Starters: Tom Poholsky vs Johnny Antonelli | Fourth | 11½ out |
| Tuesday, July 31 |
| » Defeated Pirates (43-53), 7-0 | Forbes Field (4-3) | 47-47 | Won 3 |
| » Starters: Murry Dickson vs Red Munger | Fourth | 11 out |
| Wednesday, August 1 |
| » Defeated Pirates (43-54), 4-1 | Forbes Field (5-3) | 48-47 | Won 4 |
| » Starters: Willard Schmidt vs Ron Kline | Fourth | 10 out |
| Thursday, August 2 |
| » Defeated Pirates (43-55), 7-5 | Forbes Field (6-3) | 49-47 | Won 5 |
| » Starters: Vinegar Bend Mizell vs Bob Friend | Fourth | 9 out |
| Friday, August 3 |
| » Defeated Dodgers (57-42), 11-8 | Ebbets Field (2-3) | 50-47 | Won 6 |
| » Starters: Tom Poholsky vs Roger Craig | Fourth | 8 out |
| Saturday, August 4 |
| » Lost to Dodgers (58-42), 12-4 | Ebbets Field (2-4) | 50-48 | |
| » Starters: Bob Blaylock vs Carl Erskine | Fourth | 9 out |
| Sunday, August 5 |
| » Lost to Dodgers (59-42), 7-0 | Ebbets Field (2-5) | 50-49 | Lost 2 |
| » Starters: Murry Dickson vs Sal Maglie | Fourth | 11 out |
| » Lost to Dodgers (60-42), 5-3 | Ebbets Field (2-6) | 50-50 | Lost 3 |
| » Starters: Willard Schmidt vs Sandy Koufax | Fourth | 11 out |
| Monday, August 6 |
| » Lost to Reds (60-43), 7-6 | Crosley Field (1-5) | 50-51 | Lost 4 |
| » Starters: Jackie Collum vs Joe Nuxhall | Fourth | 11 out |
| Tuesday, August 7 |
| » Defeated Reds (60-44), 8-4 | Crosley Field (2-5) | 51-51 | |
| » Starters: Willard Schmidt vs Brooks Lawrence | Fourth | 11 out |
| Wednesday, August 8 |
| » Lost to Braves (62-39), 10-1 | County Stadium (2-2) | 51-52 | |
| » Starters: Bob Blaylock vs Bob Trowbridge | Fourth | 11 out |
| » Defeated Braves (62-40), 3-2 | County Stadium (3-2) | 52-52 | |
| » Starters: Herm Wehmeier vs Lew Burdette | Fourth | 11 out |
| Thursday, August 9 |
| » Lost to Braves (63-40), 4-1 | County Stadium (3-3) | 52-53 | |
| » Starters: Murry Dickson vs Taylor Phillips | Fourth | 11 out |
| » Defeated Braves (63-41), 5-1 | County Stadium (4-3) | 53-53 | |
| » Starters: Tom Poholsky vs Gene Conley | Fourth | 11 out |
| Friday, August 10 |
| » Defeated Cubs (43-61), 4-3 | Wrigley Field (3-3) | 54-53 | Won 2 |
| » Starters: Vinegar Bend Mizell vs Warren Hacker | Fourth | 10 out |
| Saturday, August 11 |
| » Defeated Cubs (43-62), 3-1 | Wrigley Field (4-3) | 55-53 | Won 3 |
| » Starters: Willard Schmidt vs Sam Jones | Fourth | 10 out |
| Sunday, August 12 |
| » Lost to Cubs (44-62), 6-2 | Wrigley Field (4-4) | 55-54 | |
| » Starters: Bob Blaylock vs Bob Rush | Fourth | 11 out |
| » Tied Cubs, 0-0 | Wrigley Field (4-4) | 55-54 | |
| » Starters: Herm Wehmeier vs Jim Davis | Fourth | 11 out |
| Tuesday, August 14 |
| » Defeated Braves (66-43), 6-2 | Sportsman's Park III (29-23) | 56-54 | |
| » Starters: Bob Buhl vs Murry Dickson | Fourth | 10½ out |
| Wednesday, August 15 |
| » Lost to Braves (67-43), 4-1 | Sportsman's Park III (29-24) | 56-55 | |
| » Starters: Warren Spahn vs Tom Poholsky | Fourth | 11½ out |
| Thursday, August 16 |
| » Lost to Braves (68-43), 8-0 | Sportsman's Park III (29-25) | 56-56 | Lost 2 |
| » Starters: Lew Burdette vs Vinegar Bend Mizell | Fourth | 12½ out |
| Friday, August 17 |
| » Defeated Cubs (45-66), 2-1 | Sportsman's Park III (30-25) | 57-56 | |
| » Starters: Bob Rush vs Herm Wehmeier | Fourth | 11½ out |
| Saturday, August 18 |
| » Lost to Cubs (46-66), 8-1 | Sportsman's Park III (30-26) | 57-57 | |
| » Starters: Moe Drabowsky vs Willard Schmidt | Fourth | 11½ out |
| Sunday, August 19 |
| » Defeated Cubs (46-67), 6-0 | Sportsman's Park III (31-26) | 58-57 | |
| » Starters: Don Kaiser vs Murry Dickson | Fourth | 12 out |
| » Lost to Cubs (47-67), 3-1 | Sportsman's Park III (31-27) | 58-58 | |
| » Starters: Jim Davis vs Vinegar Bend Mizell | Fourth | 12 out |
| Tuesday, August 21 |
| » Lost to Dodgers (68-47), 2-1 | Sportsman's Park III (31-28) | 58-59 | Lost 2 |
| » Starters: Carl Erskine vs Herm Wehmeier | Fourth | 14 out |
| Wednesday, August 22 |
| » Lost to Dodgers (69-47), 5-3 | Sportsman's Park III (31-29) | 58-60 | Lost 3 |
| » Starters: Roger Craig vs Tom Poholsky | Fourth | 14 out |
| Thursday, August 23 |
| » Defeated Pirates (51-69), 3-0 | Sportsman's Park III (32-29) | 59-60 | |
| » Starters: Ron Kline vs Vinegar Bend Mizell | Fourth | 13½ out |
| » Defeated Pirates (51-70), 3-2 | Sportsman's Park III (33-29) | 60-60 | Won 2 |
| » Starters: Red Munger vs Willard Schmidt | Fourth | 13½ out |
| Friday, August 24 |
| » Defeated Pirates (51-71), 6-2 | Sportsman's Park III (34-29) | 61-60 | Won 3 |
| » Starters: Fred Waters vs Murry Dickson | Fourth | 13½ out |
| Future Cardinal Neil Fiala is born in St. Louis, MO. Former Cardinal Art Fromme dies in Los Angeles, CA at the age of 73 |
| Saturday, August 25 |
| » Defeated Pirates (51-72), 8-5 | Sportsman's Park III (35-29) | 62-60 | Won 4 |
| » Starters: Vern Law vs Herm Wehmeier | Fourth | 12½ out |
| Sunday, August 26 |
| » Defeated Giants (49-71), 4-3 | Sportsman's Park III (36-29) | 63-60 | Won 5 |
| » Starters: Joe Margoneri vs Tom Poholsky | Fourth | 13 out |
| » Lost to Giants (50-71), 4-3 | Sportsman's Park III (36-30) | 63-61 | |
| » Starters: Dick Littlefield vs Vinegar Bend Mizell | Fourth | 13 out |
| Tuesday, August 28 |
| » Lost to Phillies (58-64), 6-4 | Sportsman's Park III (36-31) | 63-62 | Lost 2 |
| » Starters: Curt Simmons vs Willard Schmidt | Fourth | 12½ out |
| Wednesday, August 29 |
| » Lost to Phillies (59-64), 8-6 | Sportsman's Park III (36-32) | 63-63 | Lost 3 |
| » Starters: Robin Roberts vs Murry Dickson | Fourth | 13½ out |
| Friday, August 31 |
| » Lost to Braves (77-49), 6-5 | County Stadium (4-4) | 63-64 | Lost 4 |
| » Starters: Herm Wehmeier vs Gene Conley | Fourth | 15½ out |
| » Lost to Braves (78-49), 5-3 | County Stadium (4-5) | 63-65 | Lost 5 |
| » Starters: Tom Poholsky vs Taylor Phillips | Fourth | 15½ out |
| Saturday, September 1 |
| » Lost to Braves (79-49), 3-1 | County Stadium (4-6) | 63-66 | Lost 6 |
| » Starters: Vinegar Bend Mizell vs Warren Spahn | Fourth | 16½ out |
| Sunday, September 2 |
| » Lost to Braves (80-49), 6-3 | County Stadium (4-7) | 63-67 | Lost 7 |
| » Starters: Larry Jackson vs Bob Trowbridge | Third | 17½ out |
| Monday, September 3 |
| » Defeated Cubs (51-79), 4-2 | Sportsman's Park III (37-32) | 64-67 | |
| » Starters: Don Kaiser vs Murry Dickson | Third | 17½ out |
| » Lost to Cubs (52-79), 8-0 | Sportsman's Park III (37-33) | 64-68 | |
| » Starters: Jim Brosnan vs Lindy McDaniel | Third | 17½ out |
| Wednesday, September 5 |
| » Defeated Cubs (52-80), 2-1 | Sportsman's Park III (38-33) | 65-68 | |
| » Starters: Bob Rush vs Herm Wehmeier | Fourth | 16 out |
| Friday, September 7 |
| » Defeated Reds (80-55), 1-0 | Sportsman's Park III (39-33) | 66-68 | Won 2 |
| » Starters: Joe Nuxhall vs Vinegar Bend Mizell | Third | 15 out |
| Saturday, September 8 |
| » Defeated Reds (80-56), 6-4 | Sportsman's Park III (40-33) | 67-68 | Won 3 |
| » Starters: Brooks Lawrence vs Tom Poholsky | Fourth | 14 out |
| Sunday, September 9 |
| » Defeated Reds (80-57), 6-5 | Sportsman's Park III (41-33) | 68-68 | Won 4 |
| » Starters: Hal Jeffcoat vs Murry Dickson | Fourth | 14½ out |
| » Major-league debuts: Curt Flood (Reds) |
| Tuesday, September 11 |
| » Defeated Phillies (63-73), 5-3 | Shibe Park (6-5) | 69-68 | Won 5 |
| » Starters: Herm Wehmeier vs Curt Simmons | Third | 13½ out |
| Thursday, September 13 |
| » Defeated Giants (57-82), 5-0 | Polo Grounds V (5-4) | 70-68 | Won 6 |
| » Starters: Vinegar Bend Mizell vs Al Worthington | Fourth | 14½ out |
| Friday, September 14 |
| » Lost to Giants (58-82), 3-0 | Polo Grounds V (5-5) | 70-69 | |
| » Starters: Tom Poholsky vs Ruben Gomez | Fourth | 14½ out |
| Saturday, September 15 |
| » Defeated Giants (58-83), 9-4 | Polo Grounds V (6-5) | 71-69 | |
| » Starters: Lindy McDaniel vs Mike McCormick | Fourth | 13½ out |
| Sunday, September 16 |
| » Defeated Pirates (61-82), 3-2 | Forbes Field (7-3) | 72-69 | Won 2 |
| » Starters: Murry Dickson vs Fred Waters | Fourth | 14 out |
| » Lost to Pirates (62-82), 9-3 | Forbes Field (7-4) | 72-70 | |
| » Starters: Herm Wehmeier vs Vern Law | Fourth | 14 out |
| Tuesday, September 18 |
| » Defeated Dodgers (87-57), 6-5 | Ebbets Field (3-6) | 73-70 | |
| » Starters: Vinegar Bend Mizell vs Roger Craig | Fourth | 13½ out |
| » Major-league debuts: Don Demeter (Dodgers) |
| Wednesday, September 19 |
| » Lost to Dodgers (88-57), 17-2 | Ebbets Field (3-7) | 73-71 | |
| » Starters: Tom Poholsky vs Don Newcombe | Fourth | 14½ out |
| » Major-league debuts: Bob Aspromonte (Dodgers) |
| Friday, September 21 |
| » Lost to Reds (86-62), 9-1 | Crosley Field (2-6) | 73-72 | Lost 2 |
| » Starters: Vinegar Bend Mizell vs Joe Nuxhall | Fourth | 14½ out |
| Saturday, September 22 |
| » Lost to Reds (87-62), 6-4 | Crosley Field (2-7) | 73-73 | Lost 3 |
| » Starters: Murry Dickson vs Hal Jeffcoat | Fourth | 14½ out |
| Sunday, September 23 |
| » Lost to Reds (88-62), 3-2 | Crosley Field (2-8) | 73-74 | Lost 4 |
| » Starters: Tom Poholsky vs Don Gross | Fourth | 16 out |
| » Lost to Reds (89-62), 5-4 | Crosley Field (2-9) | 73-75 | Lost 5 |
| » Starters: Herm Wehmeier vs Tom Acker | Fourth | 16 out |
| Tuesday, September 25 |
| » Defeated Cubs (58-92), 5-1 | Wrigley Field (5-4) | 74-75 | |
| » Starters: Lindy McDaniel vs Dave Hillman | Fourth | 16½ out |
| » Lost to Cubs (59-92), 6-2 | Wrigley Field (5-5) | 74-76 | |
| » Starters: Bob Blaylock vs Don Kaiser | Fourth | 16½ out |
| Wednesday, September 26 |
| » Lost to Cubs (60-92), 3-2 | Wrigley Field (5-6) | 74-77 | Lost 2 |
| » Starters: Murry Dickson vs Jim Davis | Fourth | 17 out |
| Friday, September 28 |
| » Defeated Braves (91-61), 5-4 | Sportsman's Park III (42-33) | 75-77 | |
| » Starters: Bob Buhl vs Tom Poholsky | Fourth | 16 out |
| Saturday, September 29 |
| » Defeated Braves (91-62), 2-1 | Sportsman's Park III (43-33) | 76-77 | Won 2 |
| » Starters: Warren Spahn vs Herm Wehmeier | Fourth | 16 out |
| Sunday, September 30 |
| » Lost to Braves (92-62), 4-2 | Sportsman's Park III (43-34) | 76-78 | |
| » Starters: Lew Burdette vs Vinegar Bend Mizell | Fourth | 17 out |
| Monday, October 8 |
| Future Cardinal Jeff Lahti is born in Oregon City, OR. |
| Monday, October 22 |
| Future Cardinal Frank DiPino is born in Syracuse, NY. |
| Wednesday, December 19 |
| Future Cardinal Tom Lawless is born in Erie, PA. |
Game information provided by Retrosheet (www.retrosheet.org) |