| Thursday, February 23 |
| Former Athletic Pete Loos dies in Darby, PA at the age of 78. |
| Wednesday, March 14 |
| Former Athletic Lena Styles dies in Hunstville, AL at the age of 57. |
| Tuesday, April 17 |
| » Defeated Tigers (0-1), 2-1 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Alex Kellner vs Frank Lary | First | -- |
| » Major-league debuts: Mike Baxes (Athletics) |
| Thursday, April 19 |
| » Defeated Tigers (0-2), 4-1 | Tiger Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Bobby Shantz vs Steve Gromek | Second | ½ out |
| Friday, April 20 |
| » Lost to White Sox (3-0), 6-3 | Municipal Stadium (0-1) | 2-1 | |
| » Starters: Dick Donovan vs Lou Kretlow | Third | 1 out |
| Saturday, April 21 |
| » Defeated White Sox (3-1), 15-1 | Municipal Stadium (1-1) | 3-1 | |
| » Starters: Sandy Consuegra vs Art Ditmar | Second | ½ out |
| Sunday, April 22 |
| » Lost to White Sox (4-1), 3-0 | Municipal Stadium (1-2) | 3-2 | |
| » Starters: Billy Pierce vs Alex Kellner | Third | 1½ out |
| Tuesday, April 24 |
| » Lost to Tigers (3-4), 7-4 | Municipal Stadium (1-3) | 3-3 | Lost 2 |
| » Starters: Steve Gromek vs Arnie Portocarrero | Third | 2½ out |
| Wednesday, April 25 |
| » Lost to Indians (3-4), 5-2 | Municipal Stadium (1-4) | 3-4 | Lost 3 |
| » Starters: Herb Score vs Bobby Shantz | Fourth | 3½ out |
| Thursday, April 26 |
| » Lost to Indians (4-4), 14-2 | Municipal Stadium (1-5) | 3-5 | Lost 4 |
| » Starters: Early Wynn vs Lou Kretlow | Sixth | 2½ out |
| Friday, April 27 |
| » Lost to White Sox (5-1), 9-7 | Comiskey Park I (0-1) | 3-6 | Lost 5 |
| » Starters: Art Ditmar vs Billy Pierce | Sixth | 3½ out |
| Tuesday, May 1 |
| » Defeated Red Sox (4-6), 3-2 | Fenway Park (1-0) | 4-6 | |
| » Starters: Lou Kretlow vs Bob Porterfield | Fifth | 4 out |
| Wednesday, May 2 |
| » Lost to Red Sox (5-6), 2-0 | Fenway Park (1-1) | 4-7 | |
| » Starters: Art Ditmar vs Tom Brewer | Seventh | 3 out |
| Thursday, May 3 |
| » Defeated Yankees (9-5), 8-7 | Yankee Stadium (1-0) | 5-7 | |
| » Starters: Art Ceccarelli vs Don Larsen | Sixth | 3 out |
| Friday, May 4 |
| » Lost to Yankees (10-5), 10-6 | Yankee Stadium (1-1) | 5-8 | |
| » Starters: Alex Kellner vs Bob Turley | Sixth | 4 out |
| Saturday, May 5 |
| » Lost to Yankees (11-5), 5-2 | Yankee Stadium (1-2) | 5-9 | Lost 2 |
| » Starters: Lou Kretlow vs Mickey McDermott | Seventh | 5 out |
| Sunday, May 6 |
| » Defeated Senators (9-9), 10-7 | Griffith Stadium (1-0) | 6-9 | |
| » Starters: Troy Herriage vs Pedro Ramos | Sixth | 5 out |
| » Defeated Senators (9-10), 13-3 | Griffith Stadium (2-0) | 7-9 | Won 2 |
| » Starters: Art Ditmar vs Dick Brodowski | Sixth | 5 out |
| Tuesday, May 8 |
| » Lost to Orioles (10-11), 7-4 | Memorial Stadium (0-1) | 7-10 | |
| » Starters: Art Ceccarelli vs Hal Brown | Seventh | 6 out |
| Wednesday, May 9 |
| » Defeated Orioles (10-12), 4-0 | Memorial Stadium (1-1) | 8-10 | |
| » Starters: Art Ditmar vs Jim Wilson | Fifth | 5 out |
| Friday, May 11 |
| » Lost to Indians (12-8), 4-1 | Cleveland Stadium (0-1) | 8-11 | |
| » Starters: Lou Kretlow vs Mike Garcia | Seventh | 5½ out |
| Saturday, May 12 |
| » Lost to Indians (13-8), 5-3 | Cleveland Stadium (0-2) | 8-12 | Lost 2 |
| » Starters: Troy Herriage vs Early Wynn | Seventh | 5½ out |
| Sunday, May 13 |
| » Defeated Indians (13-9), 5-2 | Cleveland Stadium (1-2) | 9-12 | |
| » Starters: Art Ditmar vs Bob Feller | Seventh | 5½ out |
| » Lost to Indians (14-9), 9-4 | Cleveland Stadium (1-3) | 9-13 | |
| » Starters: Tom Lasorda vs Herb Score | Seventh | 5½ out |
| Tuesday, May 15 |
| » Lost to Orioles (13-14), 9-5 | Municipal Stadium (1-6) | 9-14 | Lost 2 |
| » Starters: Jim Wilson vs Lou Kretlow | Seventh | 5½ out |
| Wednesday, May 16 |
| » Lost to Orioles (14-14), 8-6 | Municipal Stadium (1-7) | 9-15 | Lost 3 |
| » Starters: Erv Palica vs Tom Lasorda | Seventh | 6½ out |
| Thursday, May 17 |
| » Lost to Red Sox (13-11), 6-1 | Municipal Stadium (1-8) | 9-16 | Lost 4 |
| » Starters: Tom Brewer vs Troy Herriage | Seventh | 7½ out |
| Friday, May 18 |
| » Lost to Red Sox (14-11), 5-4 | Municipal Stadium (1-9) | 9-17 | Lost 5 |
| » Starters: Frank Sullivan vs Art Ditmar | Eighth | 8½ out |
| Saturday, May 19 |
| » Defeated Red Sox (14-12), 5-4 | Municipal Stadium (2-9) | 10-17 | |
| » Starters: George Susce vs Lou Kretlow | Seventh | 8½ out |
| Sunday, May 20 |
| » Lost to Yankees (21-10), 4-2 | Municipal Stadium (2-10) | 10-18 | |
| » Starters: Johnny Kucks vs Jack Crimian | Eighth | 9½ out |
| Monday, May 21 |
| » Lost to Yankees (22-10), 8-5 | Municipal Stadium (2-11) | 10-19 | Lost 2 |
| » Starters: Don Larsen vs Jose Santiago | Eighth | 10½ out |
| Tuesday, May 22 |
| » Defeated Senators (12-19), 6-1 | Municipal Stadium (3-11) | 11-19 | |
| » Starters: Bunky Stewart vs Troy Herriage | Eighth | 9½ out |
| Wednesday, May 23 |
| » Defeated Senators (12-20), 7-6 | Municipal Stadium (4-11) | 12-19 | Won 2 |
| » Starters: Dean Stone vs Art Ditmar | Seventh | 9½ out |
| Friday, May 25 |
| » Defeated Tigers (13-20), 6-3 | Tiger Stadium (3-0) | 13-19 | Won 3 |
| » Starters: Lou Kretlow vs Paul Foytack | Sixth | 10 out |
| Saturday, May 26 |
| » Lost to Tigers (14-20), 12-6 | Tiger Stadium (3-1) | 13-20 | |
| » Starters: Jack Crimian vs Billy Hoeft | Seventh | 10 out |
| Sunday, May 27 |
| » Lost to Tigers (15-20), 8-2 | Tiger Stadium (3-2) | 13-21 | Lost 2 |
| » Starters: Troy Herriage vs Frank Lary | Seventh | 10 out |
| » Defeated Tigers (15-21), 5-0 | Tiger Stadium (4-2) | 14-21 | |
| » Starters: Art Ditmar vs Duke Maas | Seventh | 10 out |
| Monday, May 28 |
| » Defeated White Sox (15-15), 6-4 | Municipal Stadium (5-11) | 15-21 | Won 2 |
| » Starters: Dick Donovan vs Tom Lasorda | Seventh | 10 out |
| Tuesday, May 29 |
| » Lost to White Sox (16-15), 7-4 | Municipal Stadium (5-12) | 15-22 | |
| » Starters: Howie Pollet vs Tom Gorman | Eighth | 10 out |
| Wednesday, May 30 |
| » Lost to Tigers (17-21), 11-3 | Municipal Stadium (5-13) | 15-23 | Lost 2 |
| » Starters: Paul Foytack vs Lou Kretlow | Eighth | 12 out |
| » Lost to Tigers (18-21), 5-1 | Municipal Stadium (5-14) | 15-24 | Lost 3 |
| » Starters: Virgil Trucks vs Art Ditmar | Eighth | 12 out |
| Friday, June 1 |
| » Lost to Red Sox (21-19), 5-0 | Fenway Park (1-2) | 15-25 | Lost 4 |
| » Starters: Troy Herriage vs Tom Brewer | Eighth | 12½ out |
| Saturday, June 2 |
| » Defeated Red Sox (21-20), 11-3 | Fenway Park (2-2) | 16-25 | |
| » Starters: Tom Gorman vs Frank Sullivan | Eighth | 12 out |
| Sunday, June 3 |
| » Defeated Red Sox (21-21), 7-6 | Fenway Park (3-2) | 17-25 | Won 2 |
| » Starters: Art Ditmar vs Willard Nixon | Sixth | 10½ out |
| Tuesday, June 5 |
| » Defeated Yankees (29-17), 7-4 | Yankee Stadium (2-2) | 18-25 | Won 3 |
| » Starters: Lou Kretlow vs Johnny Kucks | Seventh | 9½ out |
| Wednesday, June 6 |
| » Lost to Yankees (30-17), 10-5 | Yankee Stadium (2-3) | 18-26 | |
| » Starters: Tom Lasorda vs Bob Grim | Seventh | 10½ out |
| Thursday, June 7 |
| » Lost to Yankees (31-17), 9-1 | Yankee Stadium (2-4) | 18-27 | Lost 2 |
| » Starters: Alex Kellner vs Bob Turley | Eighth | 11½ out |
| Friday, June 8 |
| » Lost to Orioles (22-26), 6-3 | Memorial Stadium (1-2) | 18-28 | Lost 3 |
| » Starters: Art Ditmar vs Erv Palica | Eighth | 11½ out |
| Saturday, June 9 |
| » Lost to Orioles (23-26), 4-1 | Memorial Stadium (1-3) | 18-29 | Lost 4 |
| » Starters: Troy Herriage vs Ray Moore | Seventh | 12 out |
| » Lost to Orioles (24-26), 7-5 | Memorial Stadium (1-4) | 18-30 | Lost 5 |
| » Starters: Tom Gorman vs Mike Fornieles | Seventh | 12 out |
| Sunday, June 10 |
| » Defeated Orioles (24-27), 7-3 | Memorial Stadium (2-4) | 19-30 | |
| » Starters: Jose Santiago vs Connie Johnson | Eighth | 12 out |
| Monday, June 11 |
| » Lost to Senators (23-31), 4-3 | Griffith Stadium (2-1) | 19-31 | |
| » Starters: Lou Kretlow vs Connie Grob | Eighth | 12 out |
| » Defeated Senators (23-32), 6-3 | Griffith Stadium (3-1) | 20-31 | |
| » Starters: Alex Kellner vs Dean Stone | Eighth | 12 out |
| Tuesday, June 12 |
| » Defeated Senators (23-33), 9-3 | Griffith Stadium (4-1) | 21-31 | Won 2 |
| » Starters: Jose Santiago vs Bunky Stewart | Eighth | 12 out |
| Wednesday, June 13 |
| » Defeated Senators (23-34), 13-4 | Griffith Stadium (5-1) | 22-31 | Won 3 |
| » Starters: Art Ditmar vs Pedro Ramos | Seventh | 11 out |
| Friday, June 15 |
| » Lost to Orioles (26-29), 1-0 | Municipal Stadium (5-15) | 22-32 | |
| » Starters: Ray Moore vs Lou Kretlow | Sixth | 12½ out |
| Saturday, June 16 |
| » Lost to Orioles (27-29), 6-2 | Municipal Stadium (5-16) | 22-33 | Lost 2 |
| » Starters: Connie Johnson vs Jack Crimian | Sixth | 13½ out |
| Sunday, June 17 |
| » Lost to Orioles (28-29), 7-2 | Municipal Stadium (5-17) | 22-34 | Lost 3 |
| » Starters: Hal Brown vs Art Ditmar | Seventh | 14½ out |
| Monday, June 18 |
| » Defeated Senators (24-38), 4-3 | Municipal Stadium (6-17) | 23-34 | |
| » Starters: Hal Griggs vs Alex Kellner | Seventh | 14½ out |
| Tuesday, June 19 |
| » Lost to Senators (25-38), 10-5 | Municipal Stadium (6-18) | 23-35 | |
| » Starters: Bunky Stewart vs Jose Santiago | Sixth | 15½ out |
| Wednesday, June 20 |
| » Lost to Senators (26-38), 5-4 | Municipal Stadium (6-19) | 23-36 | Lost 2 |
| » Starters: Bob Wiesler vs Troy Herriage | Eighth | 16½ out |
| Thursday, June 21 |
| » Defeated Senators (26-39), 15-6 | Municipal Stadium (7-19) | 24-36 | |
| » Starters: Dean Stone vs Jose Santiago | Seventh | 16 out |
| Friday, June 22 |
| » Lost to Red Sox (30-29), 6-3 | Municipal Stadium (7-20) | 24-37 | |
| » Starters: Frank Sullivan vs Art Ditmar | Eighth | 16 out |
| Saturday, June 23 |
| » Lost to Red Sox (31-29), 6-3 | Municipal Stadium (7-21) | 24-38 | Lost 2 |
| » Starters: Mel Parnell vs Tom Gorman | Eighth | 16 out |
| Sunday, June 24 |
| » Defeated Red Sox (31-30), 5-2 | Municipal Stadium (8-21) | 25-38 | |
| » Starters: Dave Sisler vs Alex Kellner | Seventh | 14½ out |
| Monday, June 25 |
| » Lost to Yankees (41-24), 9-3 | Municipal Stadium (8-22) | 25-39 | |
| » Starters: Johnny Kucks vs Troy Herriage | Seventh | 15½ out |
| Tuesday, June 26 |
| » Lost to Yankees (42-24), 8-4 | Municipal Stadium (8-23) | 25-40 | Lost 2 |
| » Starters: Whitey Ford vs Tom Gorman | Eighth | 16½ out |
| Wednesday, June 27 |
| » Lost to Yankees (43-24), 5-2 | Municipal Stadium (8-24) | 25-41 | Lost 3 |
| » Starters: Tom Sturdivant vs Art Ditmar | Eighth | 17½ out |
| Thursday, June 28 |
| » Lost to Tigers (28-36), 4-0 | Municipal Stadium (8-25) | 25-42 | Lost 4 |
| » Starters: Virgil Trucks vs Jack McMahan | Eighth | 18 out |
| Friday, June 29 |
| » Lost to Tigers (29-36), 5-0 | Municipal Stadium (8-26) | 25-43 | Lost 5 |
| » Starters: Billy Hoeft vs Tom Lasorda | Eighth | 19 out |
| Saturday, June 30 |
| » Lost to Tigers (30-36), 14-2 | Municipal Stadium (8-27) | 25-44 | Lost 6 |
| » Starters: Paul Foytack vs Alex Kellner | Eighth | 19 out |
| Sunday, July 1 |
| » Defeated Tigers (30-37), 4-3 | Municipal Stadium (9-27) | 26-44 | |
| » Starters: Frank Lary vs Troy Herriage | Eighth | 19½ out |
| Tuesday, July 3 |
| » Lost to Indians (40-29), 9-3 | Cleveland Stadium (1-4) | 26-45 | |
| » Starters: Art Ditmar vs Mike Garcia | Eighth | 20½ out |
| Wednesday, July 4 |
| » Lost to White Sox (42-26), 5-2 | Comiskey Park I (0-2) | 26-46 | Lost 2 |
| » Starters: Jack McMahan vs Billy Pierce | Eighth | 20½ out |
| » Defeated White Sox (42-27), 3-2 | Comiskey Park I (1-2) | 27-46 | |
| » Starters: Alex Kellner vs Gerry Staley | Eighth | 20½ out |
| Friday, July 6 |
| » Lost to Indians (43-30), 4-2 | Municipal Stadium (9-28) | 27-47 | |
| » Starters: Mike Garcia vs Troy Herriage | Eighth | 22 out |
| Saturday, July 7 |
| » Defeated Indians (43-31), 5-2 | Municipal Stadium (10-28) | 28-47 | |
| » Starters: Herb Score vs Art Ditmar | Eighth | 22 out |
| Sunday, July 8 |
| » Lost to Indians (44-31), 17-3 | Municipal Stadium (10-29) | 28-48 | |
| » Starters: Early Wynn vs Jack McMahan | Eighth | 23 out |
| Thursday, July 12 |
| » Lost to Orioles (34-43), 4-0 | Memorial Stadium (2-5) | 28-49 | Lost 2 |
| » Starters: Art Ditmar vs Bill Wight | Eighth | 24 out |
| Friday, July 13 |
| » Defeated Orioles (34-44), 3-2 | Memorial Stadium (3-5) | 29-49 | |
| » Starters: Alex Kellner vs Connie Johnson | Eighth | 24 out |
| Saturday, July 14 |
| » Lost to Orioles (35-44), 1-0 | Memorial Stadium (3-6) | 29-50 | |
| » Starters: Jack McMahan vs Mike Fornieles | Eighth | 25 out |
| Sunday, July 15 |
| » Defeated Senators (32-53), 8-0 | Griffith Stadium (6-1) | 30-50 | |
| » Starters: Wally Burnette vs Chuck Stobbs | Eighth | 26 out |
| » Lost to Senators (33-53), 7-3 | Griffith Stadium (6-2) | 30-51 | |
| » Starters: Lou Kretlow vs Dean Stone | Eighth | 26 out |
| » Major-league debuts: Wally Burnette (Athletics) |
| Tuesday, July 17 |
| » Lost to Red Sox (45-37), 10-0 | Fenway Park (3-3) | 30-52 | Lost 2 |
| » Starters: Art Ditmar vs Tom Brewer | Eighth | 27½ out |
| » Lost to Red Sox (46-37), 1-0 | Fenway Park (3-4) | 30-53 | Lost 3 |
| » Starters: Tom Gorman vs Bob Porterfield | Eighth | 27½ out |
| Wednesday, July 18 |
| » Lost to Red Sox (47-37), 7-4 | Fenway Park (3-5) | 30-54 | Lost 4 |
| » Starters: Troy Herriage vs Mel Parnell | Eighth | 27 out |
| Thursday, July 19 |
| » Defeated Red Sox (47-38), 8-4 | Fenway Park (4-5) | 31-54 | |
| » Starters: Wally Burnette vs Dave Sisler | Eighth | 27 out |
| Friday, July 20 |
| » Lost to Yankees (60-28), 6-2 | Yankee Stadium (2-5) | 31-55 | |
| » Starters: Jack McMahan vs Whitey Ford | Eighth | 28 out |
| Sunday, July 22 |
| » Defeated Yankees (60-29), 7-4 | Yankee Stadium (3-5) | 32-55 | |
| » Starters: Alex Kellner vs Johnny Kucks | Eighth | 28 out |
| » Lost to Yankees (61-29), 13-4 | Yankee Stadium (3-6) | 32-56 | |
| » Starters: Tom Gorman vs Rip Coleman | Eighth | 28 out |
| Monday, July 23 |
| » Defeated White Sox (45-40), 3-2 | Comiskey Park I (2-2) | 33-56 | |
| » Starters: Jack McMahan vs Jim Wilson | Eighth | 27½ out |
| Tuesday, July 24 |
| » Lost to Red Sox (50-39), 3-2 | Municipal Stadium (10-30) | 33-57 | |
| » Starters: Mel Parnell vs Wally Burnette | Eighth | 27½ out |
| Wednesday, July 25 |
| » Defeated Red Sox (50-40), 9-6 | Municipal Stadium (11-30) | 34-57 | |
| » Starters: Bob Porterfield vs Art Ditmar | Seventh | 27½ out |
| Thursday, July 26 |
| » Lost to Red Sox (51-40), 5-3 | Municipal Stadium (11-31) | 34-58 | |
| » Starters: Frank Sullivan vs Troy Herriage | Eighth | 28½ out |
| Friday, July 27 |
| » Lost to Yankees (64-30), 10-9 | Municipal Stadium (11-32) | 34-59 | Lost 2 |
| » Starters: Johnny Kucks vs Jack McMahan | Seventh | 29½ out |
| Saturday, July 28 |
| » Lost to Yankees (65-30), 14-3 | Municipal Stadium (11-33) | 34-60 | Lost 3 |
| » Starters: Tom Sturdivant vs Alex Kellner | Eighth | 30½ out |
| Sunday, July 29 |
| » Lost to Yankees (66-30), 5-3 | Municipal Stadium (11-34) | 34-61 | Lost 4 |
| » Starters: Bob Turley vs Art Ditmar | Seventh | 31½ out |
| Monday, July 30 |
| » Lost to Orioles (44-53), 4-3 | Municipal Stadium (11-35) | 34-62 | Lost 5 |
| » Starters: Ray Moore vs Wally Burnette | Seventh | 32½ out |
| Tuesday, July 31 |
| » Lost to Orioles (45-53), 5-1 | Municipal Stadium (11-36) | 34-63 | Lost 6 |
| » Starters: Hal Brown vs Troy Herriage | Seventh | 32½ out |
| Wednesday, August 1 |
| » Defeated Orioles (45-54), 9-4 | Municipal Stadium (12-36) | 35-63 | |
| » Starters: Connie Johnson vs Lou Kretlow | Seventh | 31½ out |
| Thursday, August 2 |
| » Defeated Orioles (45-55), 3-2 | Municipal Stadium (13-36) | 36-63 | Won 2 |
| » Starters: Mike Fornieles vs Alex Kellner | Seventh | 30½ out |
| Friday, August 3 |
| » Lost to Senators (41-61), 2-1 | Municipal Stadium (13-37) | 36-64 | |
| » Starters: Camilo Pascual vs Art Ditmar | Eighth | 30½ out |
| Saturday, August 4 |
| » Lost to Senators (42-61), 5-4 | Municipal Stadium (13-38) | 36-65 | Lost 2 |
| » Starters: Pedro Ramos vs Wally Burnette | Eighth | 30½ out |
| Sunday, August 5 |
| » Lost to Senators (43-61), 10-4 | Municipal Stadium (13-39) | 36-66 | Lost 3 |
| » Starters: Chuck Stobbs vs Troy Herriage | Eighth | 30½ out |
| Tuesday, August 7 |
| » Lost to White Sox (52-48), 5-4 | Comiskey Park I (2-3) | 36-67 | Lost 4 |
| » Starters: Alex Kellner vs Bob Keegan | Eighth | 31½ out |
| » Lost to White Sox (53-48), 4-3 | Comiskey Park I (2-4) | 36-68 | Lost 5 |
| » Starters: Lou Kretlow vs Jim McDonald | Eighth | 31½ out |
| Wednesday, August 8 |
| » Lost to Tigers (50-56), 8-7 | Tiger Stadium (4-3) | 36-69 | Lost 6 |
| » Starters: Art Ditmar vs Billy Hoeft | Eighth | 32½ out |
| Thursday, August 9 |
| » Defeated Tigers (50-57), 5-3 | Tiger Stadium (5-3) | 37-69 | |
| » Starters: Jack McMahan vs Virgil Trucks | Eighth | 32½ out |
| Friday, August 10 |
| » Lost to Indians (61-45), 11-0 | Municipal Stadium (13-40) | 37-70 | |
| » Starters: Bob Lemon vs Wally Burnette | Eighth | 33½ out |
| Saturday, August 11 |
| » Lost to Indians (62-45), 8-5 | Municipal Stadium (13-41) | 37-71 | Lost 2 |
| » Starters: Mike Garcia vs Jack Crimian | Eighth | 33½ out |
| Sunday, August 12 |
| » Lost to Indians (63-45), 6-3 | Municipal Stadium (13-42) | 37-72 | Lost 3 |
| » Starters: Herb Score vs Lou Kretlow | Eighth | 35 out |
| Tuesday, August 14 |
| » Lost to White Sox (57-50), 12-1 | Municipal Stadium (13-43) | 37-73 | Lost 4 |
| » Starters: Jack Harshman vs Art Ditmar | Eighth | 36 out |
| Wednesday, August 15 |
| » Lost to White Sox (58-50), 10-0 | Municipal Stadium (13-44) | 37-74 | Lost 5 |
| » Starters: Dick Donovan vs Wally Burnette | Eighth | 37 out |
| Thursday, August 16 |
| » Lost to White Sox (59-50), 6-5 | Municipal Stadium (13-45) | 37-75 | Lost 6 |
| » Starters: Jim Wilson vs Alex Kellner | Eighth | 37 out |
| Friday, August 17 |
| » Defeated Indians (64-48), 9-3 | Cleveland Stadium (2-4) | 38-75 | |
| » Starters: Jack Crimian vs Hank Aguirre | Eighth | 36 out |
| Saturday, August 18 |
| » Lost to Indians (65-48), 8-1 | Cleveland Stadium (2-5) | 38-76 | |
| » Starters: Lou Kretlow vs Early Wynn | Eighth | 37½ out |
| Sunday, August 19 |
| » Lost to Indians (66-48), 5-2 | Cleveland Stadium (2-6) | 38-77 | Lost 2 |
| » Starters: Wally Burnette vs Bob Lemon | Eighth | 38 out |
| » Lost to Indians (67-48), 2-1 | Cleveland Stadium (2-7) | 38-78 | Lost 3 |
| » Starters: Art Ditmar vs Mike Garcia | Eighth | 38 out |
| Tuesday, August 21 |
| » Lost to Orioles (53-64), 4-3 | Memorial Stadium (3-7) | 38-79 | Lost 4 |
| » Starters: Alex Kellner vs Bill Wight | Eighth | 38 out |
| Wednesday, August 22 |
| » Defeated Orioles (53-65), 7-2 | Memorial Stadium (4-7) | 39-79 | |
| » Starters: Wally Burnette vs Mike Fornieles | Eighth | 38 out |
| Thursday, August 23 |
| » Lost to Senators (50-68), 5-3 | Griffith Stadium (6-3) | 39-80 | |
| » Starters: Jack Crimian vs Chuck Stobbs | Eighth | 37½ out |
| Friday, August 24 |
| » Defeated Senators (50-69), 8-4 | Griffith Stadium (7-3) | 40-80 | |
| » Starters: Lou Kretlow vs Pedro Ramos | Eighth | 37½ out |
| Saturday, August 25 |
| » Lost to Senators (51-69), 8-4 | Griffith Stadium (7-4) | 40-81 | |
| » Starters: Art Ditmar vs Camilo Pascual | Eighth | 37½ out |
| Sunday, August 26 |
| » Lost to Red Sox (67-55), 2-1 | Fenway Park (4-6) | 40-82 | Lost 2 |
| » Starters: Tom Gorman vs Willard Nixon | Eighth | 37½ out |
| » Defeated Red Sox (67-56), 7-6 | Fenway Park (5-6) | 41-82 | |
| » Starters: Wally Burnette vs Frank Sullivan | Eighth | 37½ out |
| Tuesday, August 28 |
| » Lost to Yankees (81-46), 4-0 | Yankee Stadium (3-7) | 41-83 | |
| » Starters: Art Ditmar vs Bob Turley | Eighth | 38½ out |
| Wednesday, August 29 |
| » Lost to Yankees (82-46), 7-6 | Yankee Stadium (3-8) | 41-84 | Lost 2 |
| » Starters: Jack McMahan vs Johnny Kucks | Eighth | 39½ out |
| Friday, August 31 |
| » Lost to Tigers (62-65), 6-1 | Tiger Stadium (5-4) | 41-85 | Lost 3 |
| » Starters: Troy Herriage vs Paul Foytack | Eighth | 40½ out |
| Saturday, September 1 |
| » Lost to Tigers (63-65), 6-1 | Tiger Stadium (5-5) | 41-86 | Lost 4 |
| » Starters: Lou Kretlow vs Frank Lary | Eighth | 40½ out |
| Sunday, September 2 |
| » Lost to Tigers (64-65), 3-1 | Tiger Stadium (5-6) | 41-87 | Lost 5 |
| » Starters: Art Ditmar vs Billy Hoeft | Eighth | 40½ out |
| Monday, September 3 |
| » Defeated Indians (74-55), 5-2 | Municipal Stadium (14-45) | 42-87 | |
| » Starters: Mike Garcia vs Tom Gorman | Eighth | 41½ out |
| » Lost to Indians (75-55), 2-1 | Municipal Stadium (14-46) | 42-88 | |
| » Starters: Early Wynn vs Wally Burnette | Eighth | 41½ out |
| Tuesday, September 4 |
| » Defeated Indians (75-56), 5-2 | Municipal Stadium (15-46) | 43-88 | |
| » Starters: Herb Score vs Jack Crimian | Eighth | 41 out |
| Thursday, September 6 |
| » Lost to Tigers (66-67), 6-0 | Municipal Stadium (15-47) | 43-89 | |
| » Starters: Frank Lary vs Art Ditmar | Eighth | 42 out |
| Friday, September 7 |
| » Lost to Tigers (67-67), 12-8 | Municipal Stadium (15-48) | 43-90 | Lost 2 |
| » Starters: Billy Hoeft vs Lou Kretlow | Eighth | 42 out |
| Saturday, September 8 |
| » Lost to Tigers (68-67), 2-1 | Municipal Stadium (15-49) | 43-91 | Lost 3 |
| » Starters: Paul Foytack vs Tom Gorman | Seventh | 43 out |
| Sunday, September 9 |
| » Lost to Tigers (69-67), 7-3 | Municipal Stadium (15-50) | 43-92 | Lost 4 |
| » Starters: Virgil Trucks vs Wally Burnette | Seventh | 44 out |
| Tuesday, September 11 |
| » Lost to Yankees (89-49), 9-5 | Municipal Stadium (15-51) | 43-93 | Lost 5 |
| » Starters: Johnny Kucks vs Art Ditmar | Eighth | 45 out |
| Wednesday, September 12 |
| » Defeated Yankees (89-50), 7-4 | Municipal Stadium (16-51) | 44-93 | |
| » Starters: Tom Sturdivant vs Bill Harrington | Eighth | 44 out |
| Thursday, September 13 |
| » Lost to Yankees (90-50), 3-2 | Municipal Stadium (16-52) | 44-94 | |
| » Starters: Whitey Ford vs Tom Gorman | Eighth | 45 out |
| Friday, September 14 |
| » Lost to Senators (58-82), 4-1 | Municipal Stadium (16-53) | 44-95 | Lost 2 |
| » Starters: Ted Abernathy vs Walt Craddock | Eighth | 46 out |
| Saturday, September 15 |
| » Defeated Senators (58-83), 10-5 | Municipal Stadium (17-53) | 45-95 | |
| » Starters: Camilo Pascual vs Carl Duser | Eighth | 45 out |
| Sunday, September 16 |
| » Lost to Orioles (62-80), 3-2 | Municipal Stadium (17-54) | 45-96 | |
| » Starters: Ray Moore vs Glenn Cox | Eighth | 45 out |
| » Defeated Orioles (62-81), 10-1 | Municipal Stadium (18-54) | 46-96 | |
| » Starters: Mike Fornieles vs Art Ditmar | Eighth | 45 out |
| Tuesday, September 18 |
| » Defeated Red Sox (79-66), 6-5 | Municipal Stadium (19-54) | 47-96 | Won 2 |
| » Starters: Tom Brewer vs Tom Gorman | Eighth | 45 out |
| Wednesday, September 19 |
| » Defeated Red Sox (79-67), 8-1 | Municipal Stadium (20-54) | 48-96 | Won 3 |
| » Starters: Dave Sisler vs Wally Burnette | Eighth | 44½ out |
| Friday, September 21 |
| » Lost to White Sox (81-63), 4-2 | Comiskey Park I (2-5) | 48-97 | |
| » Starters: Glenn Cox vs Jack Harshman | Eighth | 44 out |
| » Defeated White Sox (81-64), 3-2 | Comiskey Park I (3-5) | 49-97 | |
| » Starters: Art Ditmar vs Dick Donovan | Eighth | 44 out |
| Saturday, September 22 |
| » Lost to White Sox (82-64), 17-3 | Comiskey Park I (3-6) | 49-98 | |
| » Starters: Carl Duser vs Jim Wilson | Eighth | 45 out |
| Sunday, September 23 |
| » Defeated White Sox (82-65), 3-2 | Comiskey Park I (4-6) | 50-98 | |
| » Starters: Tom Gorman vs Billy Pierce | Eighth | 45½ out |
| » Lost to White Sox (83-65), 5-1 | Comiskey Park I (4-7) | 50-99 | |
| » Starters: Walt Craddock vs Gerry Staley | Eighth | 45½ out |
| Tuesday, September 25 |
| » Lost to Indians (86-64), 4-1 | Cleveland Stadium (2-8) | 50-100 | Lost 2 |
| » Starters: Wally Burnette vs Early Wynn | Eighth | 46 out |
| Wednesday, September 26 |
| » Lost to Indians (87-64), 8-4 | Cleveland Stadium (2-9) | 50-101 | Lost 3 |
| » Starters: Art Ditmar vs Herb Score | Eighth | 46 out |
| Friday, September 28 |
| » Defeated White Sox (84-68), 6-5 | Municipal Stadium (21-54) | 51-101 | |
| » Starters: Billy Pierce vs Alex Kellner | Eighth | 46 out |
| Saturday, September 29 |
| » Lost to White Sox (85-68), 5-1 | Municipal Stadium (21-55) | 51-102 | |
| » Starters: Dick Donovan vs Glenn Cox | Eighth | 46 out |
| Sunday, September 30 |
| » Defeated White Sox (85-69), 7-6 | Municipal Stadium (22-55) | 52-102 | |
| » Starters: Jim Derrington vs George Brunet | Eighth | 45 out |
| Saturday, November 3 |
| Future Athletic Bob Welch is born in Detroit, MI. |
| Sunday, December 23 |
| Future Athletic Bert Bradley is born in Athens, GA. |
Game information provided by Retrosheet (www.retrosheet.org) |