| Saturday, January 1 |
| Future White Sox LaMarr Hoyt is born in Columbia, SC. |
| Friday, February 4 |
| Future White Sox Rusty Kuntz is born in Orange, CA. |
| Saturday, February 12 |
| Future White Sox Chet Lemon is born in Jackson, MS. Future White Sox Steve Mura is born in New Orleans, LA. |
| Sunday, March 27 |
| Former White Sox Frank Roth dies in Burlington, WI at the age of 77. |
| Monday, April 11 |
| » Major-league debuts: Ernie Oravetz and Pedro Ramos (Senators) Don Ferrarese and Don Leppert (Orioles) |
| Tuesday, April 12 |
| » Lost to Indians (1-0), 5-1 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Virgil Trucks vs Bob Lemon | Third | 1 out |
| Wednesday, April 13 |
| » Major-league debuts: Ted Abernathy (Senators) |
| Thursday, April 14 |
| » Defeated Athletics (1-2), 7-1 | Comiskey Park I (1-0) | 1-1 | |
| » Starters: Bobby Shantz vs Sandy Consuegra | Second | 1 out |
| Friday, April 15 |
| » Major-league debuts: Herb Score (Indians) |
| Saturday, April 16 |
| » Defeated Indians (3-1), 9-4 | Comiskey Park I (2-0) | 2-1 | Won 2 |
| » Starters: Bob Feller vs Billy Pierce | Second | ½ out |
| Sunday, April 17 |
| » Defeated Indians (3-2), 3-1 | Comiskey Park I (3-0) | 3-1 | Won 3 |
| » Starters: Art Houtteman vs Jack Harshman | Third | 1½ out |
| » Lost to Indians (4-2), 4-2 | Comiskey Park I (3-1) | 3-2 | |
| » Starters: Bob Lemon vs Virgil Trucks | Third | 1½ out |
| Tuesday, April 19 |
| Future White Sox Mike Colbern is born in Santa Monica, CA. |
| Thursday, April 21 |
| » Defeated Tigers (3-4), 9-1 | Tiger Stadium (1-0) | 4-2 | |
| » Starters: Mike Fornieles vs Ned Garver | Second | 1 out |
| » Major-league debuts: Duke Maas (Tigers) |
| Friday, April 22 |
| » Defeated Athletics (2-6), 5-3 | Municipal Stadium (1-0) | 5-2 | Won 2 |
| » Starters: Virgil Trucks vs Arnie Portocarrero | First | -- |
| Saturday, April 23 |
| » Defeated Athletics (2-7), 29-6 | Municipal Stadium (2-0) | 6-2 | Won 3 |
| » Starters: Jack Harshman vs Bobby Shantz | First | -- |
| Sunday, April 24 |
| » Lost to Athletics (3-7), 5-0 | Municipal Stadium (2-1) | 6-3 | |
| » Starters: Dick Donovan vs Alex Kellner | First | -- |
| Tuesday, April 26 |
| » Lost to Yankees (8-4), 5-0 | Comiskey Park I (3-2) | 6-4 | Lost 2 |
| » Starters: Bob Turley vs Mike Fornieles | Second | 1 out |
| Wednesday, April 27 |
| » Defeated Yankees (8-5), 13-4 | Comiskey Park I (4-2) | 7-4 | |
| » Starters: Whitey Ford vs Virgil Trucks | First | -- |
| Thursday, April 28 |
| » Lost to Red Sox (8-6), 3-1 | Comiskey Park I (4-3) | 7-5 | |
| » Starters: Ike Delock vs Jack Harshman | Third | 1 out |
| Friday, April 29 |
| » Defeated Red Sox (8-7), 7-0 | Comiskey Park I (5-3) | 8-5 | |
| » Starters: Willard Nixon vs Dick Donovan | Second | ½ out |
| » Major-league debuts: Bob Smith and Joe Trimble (Red Sox) |
| Saturday, April 30 |
| » Defeated Red Sox (8-8), 3-1 | Comiskey Park I (6-3) | 9-5 | Won 2 |
| » Starters: George Susce vs Sandy Consuegra | Second | ½ out |
| Sunday, May 1 |
| » Lost to Orioles (5-12), 9-8 | Comiskey Park I (6-4) | 9-6 | |
| » Starters: Joe Coleman vs Ted Gray | Second | ½ out |
| » Defeated Orioles (5-13), 6-3 | Comiskey Park I (7-4) | 10-6 | |
| » Starters: Jim Wilson vs Billy Pierce | Second | ½ out |
| Future White Sox Ray Searage is born in Freeport, NY. |
| Tuesday, May 3 |
| » Defeated Senators (6-12), 5-3 | Comiskey Park I (8-4) | 11-6 | Won 2 |
| » Starters: Mickey McDermott vs Mike Fornieles | Third | 1 out |
| Wednesday, May 4 |
| » Lost to Senators (7-12), 5-4 | Comiskey Park I (8-5) | 11-7 | |
| » Starters: Bob Porterfield vs Jack Harshman | Third | 1 out |
| Friday, May 6 |
| » Defeated Tigers (13-8), 1-0 | Comiskey Park I (9-5) | 12-7 | |
| » Starters: Ned Garver vs Virgil Trucks | Second | 1 out |
| Saturday, May 7 |
| » Lost to Tigers (14-8), 7-1 | Comiskey Park I (9-6) | 12-8 | |
| » Starters: Steve Gromek vs Billy Pierce | Fourth | 2 out |
| Sunday, May 8 |
| » Defeated Tigers (14-9), 5-4 | Comiskey Park I (10-6) | 13-8 | |
| » Starters: Billy Hoeft vs Sandy Consuegra | Second | 2 out |
| » Defeated Tigers (14-10), 1-0 | Comiskey Park I (11-6) | 14-8 | Won 2 |
| » Starters: Frank Lary vs Dick Donovan | Second | 2 out |
| Tuesday, May 10 |
| » Defeated Red Sox (9-17), 4-2 | Fenway Park (1-0) | 15-8 | Won 3 |
| » Starters: Bob Keegan vs Tom Brewer | Second | 2 out |
| Wednesday, May 11 |
| » Lost to Red Sox (10-17), 4-3 | Fenway Park (1-1) | 15-9 | |
| » Starters: Virgil Trucks vs Frank Sullivan | Second | 3 out |
| Thursday, May 12 |
| » Defeated Orioles (8-19), 6-2 | Memorial Stadium (1-0) | 16-9 | |
| » Starters: Jack Harshman vs Saul Rogovin | Second | 2 out |
| Sunday, May 15 |
| » Defeated Senators (11-16), 3-0 | Griffith Stadium (1-0) | 17-9 | Won 2 |
| » Starters: Dick Donovan vs Johnny Schmitz | Second | 1 out |
| » Defeated Senators (11-17), 5-4 | Griffith Stadium (2-0) | 18-9 | Won 3 |
| » Starters: Bob Keegan vs Chuck Stobbs | Second | 1 out |
| Tuesday, May 17 |
| » Lost to Yankees (18-11), 1-0 | Yankee Stadium (0-1) | 18-10 | |
| » Starters: Billy Pierce vs Whitey Ford | Second | 1 out |
| Wednesday, May 18 |
| » Lost to Yankees (19-11), 11-6 | Yankee Stadium (0-2) | 18-11 | Lost 2 |
| » Starters: Virgil Trucks vs Bob Grim | Third | 2 out |
| Friday, May 20 |
| » Lost to Athletics (13-19), 1-0 | Comiskey Park I (11-7) | 18-12 | Lost 3 |
| » Starters: Art Ditmar vs Sandy Consuegra | Third | 2 out |
| Saturday, May 21 |
| » Defeated Athletics (13-20), 7-4 | Comiskey Park I (12-7) | 19-12 | |
| » Starters: Bobby Shantz vs Dick Donovan | Third | 1½ out |
| Sunday, May 22 |
| » Lost to Athletics (14-20), 7-2 | Comiskey Park I (12-8) | 19-13 | |
| » Starters: Alex Kellner vs Bob Keegan | Third | 2½ out |
| » Defeated Athletics (14-21), 10-6 | Comiskey Park I (13-8) | 20-13 | |
| » Starters: Art Ceccarelli vs Mike Fornieles | Third | 2½ out |
| Tuesday, May 24 |
| » Defeated Indians (22-13), 4-1 | Cleveland Stadium (1-1) | 21-13 | Won 2 |
| » Starters: Billy Pierce vs Herb Score | Third | 1½ out |
| Thursday, May 26 |
| » Defeated Indians (22-14), 3-1 | Cleveland Stadium (2-1) | 22-13 | Won 3 |
| » Starters: Jack Harshman vs Bob Lemon | Third | 3 out |
| » Lost to Indians (23-14), 10-9 | Cleveland Stadium (2-2) | 22-14 | |
| » Starters: Sandy Consuegra vs Mike Garcia | Third | 3 out |
| Friday, May 27 |
| » Lost to Tigers (22-16), 1-0 | Tiger Stadium (1-1) | 22-15 | Lost 2 |
| » Starters: Dick Donovan vs Billy Hoeft | Third | 4 out |
| Future White Sox Ross Baumgarten is born in Highland Park, IL. |
| Saturday, May 28 |
| » Defeated Tigers (22-17), 16-4 | Tiger Stadium (2-1) | 23-15 | |
| » Starters: Virgil Trucks vs Duke Maas | Third | 4 out |
| Sunday, May 29 |
| » Defeated Tigers (22-18), 9-3 | Tiger Stadium (3-1) | 24-15 | Won 2 |
| » Starters: Mike Fornieles vs Ned Garver | Third | 4 out |
| Monday, May 30 |
| » Lost to Indians (26-14), 9-1 | Comiskey Park I (13-9) | 24-16 | |
| » Starters: Bob Lemon vs Jack Harshman | Third | 4 out |
| » Defeated Indians (26-15), 5-0 | Comiskey Park I (14-9) | 25-16 | |
| » Starters: Mike Garcia vs Billy Pierce | Third | 4 out |
| Wednesday, June 1 |
| » Defeated Red Sox (19-27), 4-3 | Comiskey Park I (15-9) | 26-16 | Won 2 |
| » Starters: Tom Brewer vs Dick Donovan | Third | 4½ out |
| Thursday, June 2 |
| » Defeated Red Sox (19-28), 4-2 | Comiskey Park I (16-9) | 27-16 | Won 3 |
| » Starters: Mel Parnell vs Virgil Trucks | Third | 4½ out |
| Friday, June 3 |
| » Defeated Yankees (33-14), 3-2 | Comiskey Park I (17-9) | 28-16 | Won 4 |
| » Starters: Bob Turley vs Jack Harshman | Third | 3½ out |
| Saturday, June 4 |
| » Lost to Yankees (34-14), 4-3 | Comiskey Park I (17-10) | 28-17 | |
| » Starters: Ed Lopat vs Bob Keegan | Third | 4½ out |
| Sunday, June 5 |
| » Defeated Yankees (34-15), 5-3 | Comiskey Park I (18-10) | 29-17 | |
| » Starters: Tommy Byrne vs Dick Donovan | Third | 4½ out |
| » Lost to Yankees (35-15), 3-2 | Comiskey Park I (18-11) | 29-18 | |
| » Starters: Whitey Ford vs Billy Pierce | Third | 4½ out |
| Wednesday, June 8 |
| » Lost to Orioles (16-36), 3-2 | Comiskey Park I (18-12) | 29-19 | Lost 2 |
| » Starters: Harry Byrd vs Jack Harshman | Second | 4½ out |
| Friday, June 10 |
| Future White Sox Floyd Bannister is born in Pierre, SD. |
| Saturday, June 11 |
| » Defeated Senators (22-30), 10-0 | Comiskey Park I (19-12) | 30-19 | |
| » Starters: Dean Stone vs Virgil Trucks | Second | 4½ out |
| Sunday, June 12 |
| » Defeated Senators (22-31), 1-0 | Comiskey Park I (20-12) | 31-19 | Won 2 |
| » Starters: Bob Porterfield vs Billy Pierce | Second | 3½ out |
| » Defeated Senators (22-32), 8-4 | Comiskey Park I (21-12) | 32-19 | Won 3 |
| » Starters: Johnny Schmitz vs Dick Donovan | Second | 3½ out |
| Tuesday, June 14 |
| » Defeated Orioles (18-39), 1-0 | Memorial Stadium (2-0) | 33-19 | Won 4 |
| » Starters: Jack Harshman vs Saul Rogovin | Second | 3½ out |
| Wednesday, June 15 |
| » Lost to Orioles (19-39), 6-5 | Memorial Stadium (2-1) | 33-20 | |
| » Starters: Bob Keegan vs Erv Palica | Second | 3 out |
| » Defeated Orioles (19-40), 2-0 | Memorial Stadium (3-1) | 34-20 | |
| » Starters: Mike Fornieles vs Jim Wilson | Second | 3 out |
| Thursday, June 16 |
| » Defeated Orioles (19-41), 8-0 | Memorial Stadium (4-1) | 35-20 | Won 2 |
| » Starters: Virgil Trucks vs Duane Pillette | Second | 3 out |
| Friday, June 17 |
| » Defeated Yankees (40-22), 2-1 | Yankee Stadium (1-2) | 36-20 | Won 3 |
| » Starters: Dick Donovan vs Whitey Ford | Second | 3 out |
| Saturday, June 18 |
| » Defeated Yankees (40-23), 6-3 | Yankee Stadium (2-2) | 37-20 | Won 4 |
| » Starters: Harry Byrd vs Bob Turley | First | -- |
| Sunday, June 19 |
| » Lost to Yankees (41-23), 7-1 | Yankee Stadium (2-3) | 37-21 | |
| » Starters: Billy Pierce vs Ed Lopat | Second | 3 out |
| » Lost to Yankees (42-23), 5-2 | Yankee Stadium (2-4) | 37-22 | Lost 2 |
| » Starters: Jack Harshman vs Johnny Kucks | Second | 3 out |
| Tuesday, June 21 |
| » Defeated Senators (23-38), 6-1 | Griffith Stadium (3-0) | 38-22 | |
| » Starters: Virgil Trucks vs Bob Porterfield | Second | 3 out |
| » Major-league debuts: Jose Valdivielso (Senators) |
| Wednesday, June 22 |
| » Defeated Senators (23-39), 3-0 | Griffith Stadium (4-0) | 39-22 | Won 2 |
| » Starters: Dick Donovan vs Dean Stone | Second | 3 out |
| Former White Sox Frankie Hayes dies in Point Pleasant, NJ at the age of 41. |
| Thursday, June 23 |
| » Defeated Senators (23-40), 7-0 | Griffith Stadium (5-0) | 40-22 | Won 3 |
| » Starters: Harry Byrd vs Camilo Pascual | Second | 3 out |
| Friday, June 24 |
| » Defeated Red Sox (34-33), 3-2 | Fenway Park (2-1) | 41-22 | Won 4 |
| » Starters: Billy Pierce vs Mel Parnell | Second | 3 out |
| Saturday, June 25 |
| » Defeated Red Sox (34-34), 8-3 | Fenway Park (3-1) | 42-22 | Won 5 |
| » Starters: Jack Harshman vs George Susce | Second | 3 out |
| Sunday, June 26 |
| » Lost to Red Sox (35-34), 5-2 | Fenway Park (3-2) | 42-23 | |
| » Starters: Virgil Trucks vs Willard Nixon | Second | 3 out |
| » Lost to Red Sox (36-34), 8-2 | Fenway Park (3-3) | 42-24 | Lost 2 |
| » Starters: Bob Keegan vs Tom Brewer | Second | 3 out |
| Tuesday, June 28 |
| » Lost to Tigers (36-31), 5-4 | Comiskey Park I (21-13) | 42-25 | Lost 3 |
| » Starters: Duke Maas vs Dick Donovan | Second | 3½ out |
| Wednesday, June 29 |
| » Lost to Tigers (37-31), 8-2 | Comiskey Park I (21-14) | 42-26 | Lost 4 |
| » Starters: Billy Hoeft vs Harry Byrd | Second | 5 out |
| Thursday, June 30 |
| » Lost to Tigers (38-31), 4-3 | Comiskey Park I (21-15) | 42-27 | Lost 5 |
| » Starters: Steve Gromek vs Mike Fornieles | Second | 5½ out |
| Friday, July 1 |
| » Lost to Indians (43-30), 1-0 | Cleveland Stadium (2-3) | 42-28 | Lost 6 |
| » Starters: Billy Pierce vs Early Wynn | Second | 6½ out |
| Saturday, July 2 |
| » Defeated Indians (43-31), 2-1 | Cleveland Stadium (3-3) | 43-28 | |
| » Starters: Jack Harshman vs Herb Score | Second | 6½ out |
| Sunday, July 3 |
| » Lost to Indians (44-31), 14-9 | Cleveland Stadium (3-4) | 43-29 | |
| » Starters: Dick Donovan vs Bob Lemon | Second | 6½ out |
| Monday, July 4 |
| » Defeated Athletics (32-42), 8-3 | Municipal Stadium (3-1) | 44-29 | |
| » Starters: Connie Johnson vs Alex Kellner | Third | 5½ out |
| » Lost to Athletics (33-42), 4-3 | Municipal Stadium (3-2) | 44-30 | |
| » Starters: Harry Byrd vs Art Ditmar | Third | 5½ out |
| Wednesday, July 6 |
| » Lost to Tigers (39-37), 5-3 | Tiger Stadium (3-2) | 44-31 | Lost 2 |
| » Starters: Virgil Trucks vs Ned Garver | Third | 5½ out |
| Thursday, July 7 |
| » Defeated Tigers (39-38), 12-1 | Tiger Stadium (4-2) | 45-31 | |
| » Starters: Dick Donovan vs Duke Maas | Third | 5 out |
| Friday, July 8 |
| » Lost to Indians (49-32), 1-0 | Comiskey Park I (21-16) | 45-32 | |
| » Starters: Bob Lemon vs Billy Pierce | Third | 6 out |
| Saturday, July 9 |
| » Defeated Indians (49-33), 6-0 | Comiskey Park I (22-16) | 46-32 | |
| » Starters: Early Wynn vs Connie Johnson | Third | 6 out |
| Sunday, July 10 |
| » Lost to Indians (50-33), 5-2 | Comiskey Park I (22-17) | 46-33 | |
| » Starters: Art Houtteman vs Jack Harshman | Third | 6 out |
| » Defeated Indians (50-34), 4-2 | Comiskey Park I (23-17) | 47-33 | |
| » Starters: Herb Score vs Virgil Trucks | Third | 6 out |
| Wednesday, July 13 |
| Future White Sox Kevin Bell is born in Los Angeles, CA. |
| Thursday, July 14 |
| » Defeated Senators (27-55), 13-4 | Comiskey Park I (24-17) | 48-33 | Won 2 |
| » Starters: Camilo Pascual vs Connie Johnson | Third | 4½ out |
| » Defeated Senators (27-56), 5-2 | Comiskey Park I (25-17) | 49-33 | Won 3 |
| » Starters: Ted Abernathy vs Dick Donovan | Third | 4½ out |
| Friday, July 15 |
| » Defeated Senators (27-57), 5-4 | Comiskey Park I (26-17) | 50-33 | Won 4 |
| » Starters: Johnny Schmitz vs Virgil Trucks | Second | 4½ out |
| Saturday, July 16 |
| » Defeated Orioles (26-56), 4-3 | Comiskey Park I (27-17) | 51-33 | Won 5 |
| » Starters: Bill Wight vs Harry Byrd | Second | 3 out |
| Sunday, July 17 |
| » Defeated Orioles (26-57), 3-2 | Comiskey Park I (28-17) | 52-33 | Won 6 |
| » Starters: George Zuverink vs Billy Pierce | Second | 1½ out |
| » Defeated Orioles (26-58), 5-4 | Comiskey Park I (29-17) | 53-33 | Won 7 |
| » Starters: Art Schallock vs Jack Harshman | Second | 1½ out |
| Monday, July 18 |
| » Lost to Orioles (27-58), 3-0 | Comiskey Park I (29-18) | 53-34 | |
| » Starters: Jim Wilson vs Mike Fornieles | Second | 2 out |
| Tuesday, July 19 |
| » Lost to Yankees (57-33), 4-3 | Comiskey Park I (29-19) | 53-35 | Lost 2 |
| » Starters: Tommy Byrne vs Connie Johnson | Second | 3 out |
| Wednesday, July 20 |
| » Defeated Yankees (57-34), 8-6 | Comiskey Park I (30-19) | 54-35 | |
| » Starters: Bob Turley vs Dick Donovan | Second | 2 out |
| Thursday, July 21 |
| » Defeated Yankees (57-35), 9-6 | Comiskey Park I (31-19) | 55-35 | Won 2 |
| » Starters: Whitey Ford vs Virgil Trucks | Second | 1 out |
| Friday, July 22 |
| » Defeated Red Sox (53-40), 10-7 | Comiskey Park I (32-19) | 56-35 | Won 3 |
| » Starters: Tom Brewer vs Jack Harshman | First | -- |
| Saturday, July 23 |
| » Lost to Red Sox (54-40), 9-7 | Comiskey Park I (32-20) | 56-36 | |
| » Starters: Leo Kiely vs Harry Byrd | First | -- |
| Sunday, July 24 |
| » Defeated Red Sox (54-41), 4-0 | Comiskey Park I (33-20) | 57-36 | |
| » Starters: George Susce vs Billy Pierce | Second | 1 out |
| » Lost to Red Sox (55-41), 2-1 | Comiskey Park I (33-21) | 57-37 | |
| » Starters: Willard Nixon vs Connie Johnson | Second | 1 out |
| Tuesday, July 26 |
| » Lost to Yankees (60-37), 1-0 | Yankee Stadium (2-5) | 57-38 | Lost 2 |
| » Starters: Dick Donovan vs Tommy Byrne | Second | 2 out |
| Wednesday, July 27 |
| » Defeated Yankees (60-38), 7-4 | Yankee Stadium (3-5) | 58-38 | |
| » Starters: Harry Byrd vs Ed Lopat | Second | 1 out |
| Thursday, July 28 |
| » Defeated Yankees (60-39), 3-2 | Yankee Stadium (4-5) | 59-38 | Won 2 |
| » Starters: Connie Johnson vs Bob Turley | First | -- |
| Friday, July 29 |
| » Defeated Senators (34-65), 5-2 | Griffith Stadium (6-0) | 60-38 | Won 3 |
| » Starters: Virgil Trucks vs Pedro Ramos | First | -- |
| Saturday, July 30 |
| » Lost to Senators (35-65), 1-0 | Griffith Stadium (6-1) | 60-39 | |
| » Starters: Billy Pierce vs Bob Porterfield | First | -- |
| Sunday, July 31 |
| » Defeated Senators (35-66), 3-1 | Griffith Stadium (7-1) | 61-39 | |
| » Starters: Jack Harshman vs Mickey McDermott | First | -- |
| » Defeated Senators (35-67), 6-5 | Griffith Stadium (8-1) | 62-39 | Won 2 |
| » Starters: Harry Byrd vs Spec Shea | First | -- |
| Tuesday, August 2 |
| » Defeated Red Sox (60-44), 2-1 | Fenway Park (4-3) | 63-39 | Won 3 |
| » Starters: Connie Johnson vs Tom Brewer | First | -- |
| Wednesday, August 3 |
| » Lost to Red Sox (61-44), 6-4 | Fenway Park (4-4) | 63-40 | |
| » Starters: Virgil Trucks vs Mel Parnell | First | -- |
| Thursday, August 4 |
| » Lost to Red Sox (62-44), 7-3 | Fenway Park (4-5) | 63-41 | Lost 2 |
| » Starters: Billy Pierce vs Willard Nixon | First | -- |
| Friday, August 5 |
| » Lost to Orioles (34-72), 2-1 | Memorial Stadium (4-2) | 63-42 | Lost 3 |
| » Starters: Harry Byrd vs Jim Wilson | First | -- |
| Saturday, August 6 |
| » Lost to Orioles (35-72), 8-1 | Memorial Stadium (4-3) | 63-43 | Lost 4 |
| » Starters: Jack Harshman vs Erv Palica | First | -- |
| Sunday, August 7 |
| » Tied Orioles, 2-2 | Memorial Stadium (4-3) | 63-43 | |
| » Starters: Connie Johnson vs Ray Moore | First | -- |
| Tuesday, August 9 |
| » Defeated Athletics (46-65), 4-1 | Municipal Stadium (4-2) | 64-43 | |
| » Starters: Billy Pierce vs Bobby Shantz | First | -- |
| Wednesday, August 10 |
| » Lost to Athletics (47-65), 5-4 | Municipal Stadium (4-3) | 64-44 | |
| » Starters: Harry Byrd vs Alex Kellner | Second | 1½ out |
| Thursday, August 11 |
| » Defeated Athletics (47-66), 14-1 | Municipal Stadium (5-3) | 65-44 | |
| » Starters: Connie Johnson vs Vic Raschi | Second | 1½ out |
| Friday, August 12 |
| » Defeated Tigers (59-54), 2-1 | Tiger Stadium (5-2) | 66-44 | Won 2 |
| » Starters: Virgil Trucks vs Steve Gromek | Second | 2 out |
| Saturday, August 13 |
| » Lost to Tigers (60-54), 9-8 | Tiger Stadium (5-3) | 66-45 | |
| » Starters: Mike Fornieles vs Frank Lary | Second | 2 out |
| Sunday, August 14 |
| » Defeated Tigers (60-55), 5-4 | Tiger Stadium (6-3) | 67-45 | |
| » Starters: Billy Pierce vs Ned Garver | Third | 2 out |
| Tuesday, August 16 |
| » Defeated Athletics (48-70), 5-4 | Comiskey Park I (34-21) | 68-45 | Won 2 |
| » Starters: Alex Kellner vs Connie Johnson | Second | 2½ out |
| Thursday, August 18 |
| » Defeated Athletics (48-71), 6-2 | Comiskey Park I (35-21) | 69-45 | Won 3 |
| » Starters: Ray Herbert vs Virgil Trucks | Second | 2 out |
| » Lost to Athletics (49-71), 5-3 | Comiskey Park I (35-22) | 69-46 | |
| » Starters: Arnie Portocarrero vs Harry Byrd | Second | 2 out |
| Friday, August 19 |
| » Defeated Tigers (62-57), 3-0 | Comiskey Park I (36-22) | 70-46 | |
| » Starters: Steve Gromek vs Billy Pierce | Second | 2 out |
| Future White Sox Silvio Martinez is born in Santiago, D.R. |
| Saturday, August 20 |
| » Defeated Tigers (62-58), 8-7 | Comiskey Park I (37-22) | 71-46 | Won 2 |
| » Starters: Ned Garver vs Bob Keegan | Second | 2 out |
| Sunday, August 21 |
| » Defeated Tigers (62-59), 2-0 | Comiskey Park I (38-22) | 72-46 | Won 3 |
| » Starters: Billy Hoeft vs Connie Johnson | Second | 1½ out |
| » Defeated Tigers (62-60), 8-2 | Comiskey Park I (39-22) | 73-46 | Won 4 |
| » Starters: Jim Bunning vs Dick Donovan | Second | 1½ out |
| Tuesday, August 23 |
| » Defeated Orioles (37-81), 6-2 | Comiskey Park I (40-22) | 74-46 | Won 5 |
| » Starters: Erv Palica vs Virgil Trucks | First | -- |
| » Lost to Orioles (38-81), 10-3 | Comiskey Park I (40-23) | 74-47 | |
| » Starters: George Zuverink vs Sandy Consuegra | First | -- |
| Wednesday, August 24 |
| » Defeated Orioles (38-82), 14-1 | Comiskey Park I (41-23) | 75-47 | |
| » Starters: Jim Wilson vs Billy Pierce | Second | ½ out |
| » Lost to Orioles (39-82), 2-1 | Comiskey Park I (41-24) | 75-48 | |
| » Starters: Bill Wight vs Harry Byrd | Second | ½ out |
| Thursday, August 25 |
| » Lost to Senators (43-78), 6-1 | Comiskey Park I (41-25) | 75-49 | Lost 2 |
| » Starters: Bob Porterfield vs Connie Johnson | Second | 1½ out |
| Friday, August 26 |
| » Lost to Senators (44-78), 10-0 | Comiskey Park I (41-26) | 75-50 | Lost 3 |
| » Starters: Pedro Ramos vs Dick Donovan | Third | 1½ out |
| Saturday, August 27 |
| » Defeated Senators (44-79), 11-1 | Comiskey Park I (42-26) | 76-50 | |
| » Starters: Camilo Pascual vs Jack Harshman | Second | ½ out |
| Sunday, August 28 |
| » Lost to Yankees (78-50), 6-1 | Comiskey Park I (42-27) | 76-51 | |
| » Starters: Whitey Ford vs Connie Johnson | Second | ½ out |
| » Defeated Yankees (78-51), 3-2 | Comiskey Park I (43-27) | 77-51 | |
| » Starters: Bob Turley vs Billy Pierce | Second | ½ out |
| Tuesday, August 30 |
| » Defeated Red Sox (74-55), 7-5 | Comiskey Park I (44-27) | 78-51 | Won 2 |
| » Starters: Willard Nixon vs Virgil Trucks | First | -- |
| Wednesday, August 31 |
| » Defeated Red Sox (74-56), 4-2 | Comiskey Park I (45-27) | 79-51 | Won 3 |
| » Starters: Tom Brewer vs Bob Keegan | First | -- |
| Friday, September 2 |
| » Defeated Indians (79-53), 8-1 | Cleveland Stadium (4-4) | 80-51 | Won 4 |
| » Starters: Jack Harshman vs Sal Maglie | First | -- |
| Saturday, September 3 |
| » Lost to Indians (80-53), 6-1 | Cleveland Stadium (4-5) | 80-52 | |
| » Starters: Billy Pierce vs Early Wynn | First | -- |
| Sunday, September 4 |
| » Lost to Indians (81-53), 5-3 | Cleveland Stadium (4-6) | 80-53 | Lost 2 |
| » Starters: Connie Johnson vs Bob Lemon | Third | 1½ out |
| » Lost to Indians (82-53), 5-3 | Cleveland Stadium (4-7) | 80-54 | Lost 3 |
| » Starters: Dick Donovan vs Mike Garcia | Third | 1½ out |
| Monday, September 5 |
| » Lost to Tigers (70-66), 7-2 | Tiger Stadium (6-4) | 80-55 | Lost 4 |
| » Starters: Virgil Trucks vs Billy Hoeft | Third | 1½ out |
| » Defeated Tigers (70-67), 3-0 | Tiger Stadium (7-4) | 81-55 | |
| » Starters: Bob Keegan vs Frank Lary | Third | 1½ out |
| Wednesday, September 7 |
| » Defeated Senators (47-86), 4-3 | Griffith Stadium (9-1) | 82-55 | Won 2 |
| » Starters: Jack Harshman vs Pedro Ramos | Third | 1½ out |
| Thursday, September 8 |
| » Lost to Senators (48-86), 5-4 | Griffith Stadium (9-2) | 82-56 | |
| » Starters: Virgil Trucks vs Chuck Stobbs | Third | 2½ out |
| Friday, September 9 |
| » Lost to Yankees (85-54), 5-4 | Yankee Stadium (4-6) | 82-57 | Lost 2 |
| » Starters: Dick Donovan vs Don Larsen | Third | 3½ out |
| Saturday, September 10 |
| » Defeated Yankees (85-55), 9-8 | Yankee Stadium (5-6) | 83-57 | |
| » Starters: Billy Pierce vs Rip Coleman | Third | 3½ out |
| » Major-league debuts: Earl Battey (White Sox) |
| Former White Sox Shano Collins dies in Newton, MA at the age of 70. |
| Sunday, September 11 |
| » Lost to Red Sox (81-59), 6-2 | Fenway Park (4-6) | 83-58 | |
| » Starters: Bob Keegan vs Frank Sullivan | Third | 3½ out |
| » Defeated Red Sox (81-60), 7-2 | Fenway Park (5-6) | 84-58 | |
| » Starters: Connie Johnson vs George Susce | Third | 3½ out |
| Tuesday, September 13 |
| » Lost to Orioles (46-93), 2-0 | Memorial Stadium (4-4) | 84-59 | |
| » Starters: Virgil Trucks vs Ray Moore | Third | 4½ out |
| » Defeated Orioles (46-94), 9-6 | Memorial Stadium (5-4) | 85-59 | |
| » Starters: Jack Harshman vs Erv Palica | Third | 4½ out |
| Wednesday, September 14 |
| » Lost to Orioles (47-94), 8-2 | Memorial Stadium (5-5) | 85-60 | |
| » Starters: Dick Donovan vs Jim Wilson | Third | 4 out |
| » Defeated Orioles (47-95), 6-0 | Memorial Stadium (6-5) | 86-60 | |
| » Starters: Billy Pierce vs Bill Wight | Third | 4 out |
| Friday, September 16 |
| » Lost to Athletics (62-84), 13-7 | Municipal Stadium (5-4) | 86-61 | |
| » Starters: Connie Johnson vs Alex Kellner | Third | 4 out |
| Saturday, September 17 |
| » Defeated Athletics (62-85), 12-8 | Municipal Stadium (6-4) | 87-61 | |
| » Starters: Bob Keegan vs Johnny Gray | Third | 4 out |
| Sunday, September 18 |
| » Lost to Athletics (63-85), 8-1 | Municipal Stadium (6-5) | 87-62 | |
| » Starters: Dick Donovan vs Art Ditmar | Third | 5 out |
| Tuesday, September 20 |
| » Lost to Indians (91-59), 3-2 | Comiskey Park I (45-28) | 87-63 | Lost 2 |
| » Starters: Early Wynn vs Billy Pierce | Third | 6½ out |
| Wednesday, September 21 |
| » Defeated Indians (91-60), 7-2 | Comiskey Park I (46-28) | 88-63 | |
| » Starters: Bob Lemon vs Jack Harshman | Third | 6½ out |
| Friday, September 23 |
| » Defeated Athletics (63-89), 12-4 | Comiskey Park I (47-28) | 89-63 | Won 2 |
| » Starters: Arnie Portocarrero vs Sandy Consuegra | Third | 6 out |
| Saturday, September 24 |
| » Defeated Athletics (63-90), 4-0 | Comiskey Park I (48-28) | 90-63 | Won 3 |
| » Starters: Johnny Gray vs Dick Donovan | Third | 5½ out |
| Sunday, September 25 |
| » Defeated Athletics (63-91), 5-0 | Comiskey Park I (49-28) | 91-63 | Won 4 |
