| Friday, March 4 |
| Former Senator Doc Reisling dies in Tulsa, OK at the age of 81. |
| Monday, April 11 |
| » Defeated Orioles (0-1), 12-5 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Lou Kretlow vs Bob Porterfield | First | -- |
| » Major-league debuts: Ernie Oravetz and Pedro Ramos (Senators) Don Ferrarese and Don Leppert (Orioles) |
| Tuesday, April 12 |
| » Major-league debuts: Ken Boyer and Herb Moford Barney Schultz and Bill Virdon (Cardinals) |
| Wednesday, April 13 |
| » Lost to Yankees (1-0), 19-1 | Yankee Stadium (0-1) | 1-1 | |
| » Starters: Mickey McDermott vs Whitey Ford | Second | ½ out |
| » Major-league debuts: Ted Abernathy (Senators) |
| Thursday, April 14 |
| » Major-league debuts: Bob Thurman (Reds) |
| Saturday, April 16 |
| » Lost to Yankees (3-1), 5-2 | Griffith Stadium (1-1) | 1-2 | Lost 2 |
| » Starters: Tommy Byrne vs Bob Porterfield | Fourth | 1½ out |
| Sunday, April 17 |
| » Defeated Yankees (3-2), 7-3 | Griffith Stadium (2-1) | 2-2 | |
| » Starters: Ed Lopat vs Johnny Schmitz | Fourth | 2 out |
| » Major-league debuts: Johnny Kucks (Yankees) |
| Wednesday, April 20 |
| » Lost to Red Sox (6-1), 1-0 | Griffith Stadium (2-2) | 2-3 | |
| » Starters: Willard Nixon vs Chuck Stobbs | Sixth | 3 out |
| Thursday, April 21 |
| » Defeated Red Sox (6-2), 1-0 | Griffith Stadium (3-2) | 3-3 | |
| » Starters: Tom Brewer vs Bob Porterfield | Fourth | 2 out |
| Friday, April 22 |
| » Defeated Orioles (1-8), 3-2 | Memorial Stadium (1-0) | 4-3 | Won 2 |
| » Starters: Mickey McDermott vs Jim Wilson | Third | 1 out |
| Saturday, April 23 |
| » Lost to Orioles (2-8), 3-0 | Memorial Stadium (1-1) | 4-4 | |
| » Starters: Dean Stone vs Harry Byrd | Fourth | 2 out |
| » Major-league debuts: Dick Hyde (Senators) |
| Sunday, April 24 |
| » Lost to Orioles (3-8), 2-1 | Memorial Stadium (1-2) | 4-5 | Lost 2 |
| » Starters: Camilo Pascual vs Saul Rogovin | Fourth | 1½ out |
| » Defeated Orioles (3-9), 5-2 | Memorial Stadium (2-2) | 5-5 | |
| » Starters: Johnny Schmitz vs Ray Moore | Fourth | 1½ out |
| Tuesday, April 26 |
| » Lost to Indians (7-5), 3-2 | Cleveland Stadium (0-1) | 5-6 | |
| » Starters: Mickey McDermott vs Bob Lemon | Fifth | 2½ out |
| Wednesday, April 27 |
| » Lost to Indians (8-5), 6-5 | Cleveland Stadium (0-2) | 5-7 | Lost 2 |
| » Starters: Bob Porterfield vs Early Wynn | Fifth | 2½ out |
| Thursday, April 28 |
| » Lost to Tigers (8-5), 4-1 | Tiger Stadium (0-1) | 5-8 | Lost 3 |
| » Starters: Dean Stone vs Billy Hoeft | Fifth | 3½ out |
| Friday, April 29 |
| » Lost to Tigers (9-5), 3-2 | Tiger Stadium (0-2) | 5-9 | Lost 4 |
| » Starters: Camilo Pascual vs Frank Lary | Seventh | 4 out |
| Saturday, April 30 |
| » Lost to Tigers (10-5), 11-7 | Tiger Stadium (0-3) | 5-10 | Lost 5 |
| » Starters: Bob Porterfield vs Duke Maas | Sixth | 5 out |
| » Major-league debuts: Bubba Phillips (Tigers) |
| Sunday, May 1 |
| » Lost to Athletics (7-8), 16-10 | Municipal Stadium (0-1) | 5-11 | Lost 6 |
| » Starters: Mickey McDermott vs Art Ditmar | Fifth | 5½ out |
| Monday, May 2 |
| » Defeated Athletics (7-9), 12-1 | Municipal Stadium (1-1) | 6-11 | |
| » Starters: Johnny Schmitz vs Cloyd Boyer | Seventh | 5½ out |
| Tuesday, May 3 |
| » Lost to White Sox (11-6), 5-3 | Comiskey Park I (0-1) | 6-12 | |
| » Starters: Mickey McDermott vs Mike Fornieles | Seventh | 6½ out |
| Wednesday, May 4 |
| » Defeated White Sox (11-7), 5-4 | Comiskey Park I (1-1) | 7-12 | |
| » Starters: Bob Porterfield vs Jack Harshman | Seventh | 5½ out |
| Friday, May 6 |
| » Defeated Orioles (5-16), 2-1 | Griffith Stadium (4-2) | 8-12 | Won 2 |
| » Starters: Saul Rogovin vs Dean Stone | Sixth | 5½ out |
| Saturday, May 7 |
| » Lost to Orioles (6-16), 5-1 | Griffith Stadium (4-3) | 8-13 | |
| » Starters: Jim Wilson vs Johnny Schmitz | Sixth | 6½ out |
| Sunday, May 8 |
| » Lost to Orioles (7-16), 4-3 | Griffith Stadium (4-4) | 8-14 | Lost 2 |
| » Starters: Erv Palica vs Chuck Stobbs | Fifth | 7½ out |
| » Defeated Orioles (7-17), 15-7 | Griffith Stadium (5-4) | 9-14 | |
| » Starters: Bill Miller vs Camilo Pascual | Fifth | 7½ out |
| Tuesday, May 10 |
| » Defeated Tigers (14-11), 7-4 | Griffith Stadium (6-4) | 10-14 | Won 2 |
| » Starters: Duke Maas vs Bob Porterfield | Fifth | 7½ out |
| Wednesday, May 11 |
| » Lost to Tigers (15-11), 7-0 | Griffith Stadium (6-5) | 10-15 | |
| » Starters: Ned Garver vs Dean Stone | Sixth | 8½ out |
| Thursday, May 12 |
| » Defeated Indians (19-8), 3-0 | Griffith Stadium (7-5) | 11-15 | |
| » Starters: Herb Score vs Mickey McDermott | Fifth | 7½ out |
| Sunday, May 15 |
| » Lost to White Sox (17-9), 3-0 | Griffith Stadium (7-6) | 11-16 | |
| » Starters: Dick Donovan vs Johnny Schmitz | Sixth | 8½ out |
| » Lost to White Sox (18-9), 5-4 | Griffith Stadium (7-7) | 11-17 | Lost 2 |
| » Starters: Bob Keegan vs Chuck Stobbs | Sixth | 8½ out |
| Tuesday, May 17 |
| » Lost to Athletics (12-18), 1-0 | Griffith Stadium (7-8) | 11-18 | Lost 3 |
| » Starters: Alex Kellner vs Mickey McDermott | Seventh | 8½ out |
| Wednesday, May 18 |
| » Defeated Athletics (12-19), 7-2 | Griffith Stadium (8-8) | 12-18 | |
| » Starters: Art Ceccarelli vs Dean Stone | Sixth | 8½ out |
| Friday, May 20 |
| » Defeated Red Sox (15-20), 3-1 | Griffith Stadium (9-8) | 13-18 | Won 2 |
| » Starters: Frank Sullivan vs Bob Porterfield | Sixth | 7½ out |
| Saturday, May 21 |
| » Defeated Red Sox (15-21), 1-0 | Griffith Stadium (10-8) | 14-18 | Won 3 |
| » Starters: Tom Brewer vs Camilo Pascual | Fifth | 7 out |
| Tuesday, May 24 |
| » Defeated Yankees (23-12), 3-2 | Yankee Stadium (1-1) | 15-18 | Won 4 |
| » Starters: Chuck Stobbs vs Bob Grim | Fifth | 7 out |
| Wednesday, May 25 |
| » Lost to Yankees (24-12), 6-2 | Yankee Stadium (1-2) | 15-19 | |
| » Starters: Mickey McDermott vs Bob Turley | Fifth | 8 out |
| Thursday, May 26 |
| » Lost to Yankees (25-12), 8-4 | Yankee Stadium (1-3) | 15-20 | Lost 2 |
| » Starters: Johnny Schmitz vs Johnny Kucks | Fifth | 10 out |
| » Lost to Yankees (26-12), 7-3 | Yankee Stadium (1-4) | 15-21 | Lost 3 |
| » Starters: Dean Stone vs Bob Wiesler | Fifth | 10 out |
| Friday, May 27 |
| » Lost to Red Sox (17-24), 16-0 | Fenway Park (0-1) | 15-22 | Lost 4 |
| » Starters: Bob Porterfield vs Tom Brewer | Sixth | 11 out |
| Saturday, May 28 |
| » Defeated Red Sox (17-25), 5-3 | Fenway Park (1-1) | 16-22 | |
| » Starters: Camilo Pascual vs Bill Henry | Fifth | 11 out |
| Sunday, May 29 |
| » Lost to Red Sox (18-25), 12-7 | Fenway Park (1-2) | 16-23 | |
| » Starters: Chuck Stobbs vs Willard Nixon | Sixth | 12 out |
| Monday, May 30 |
| » Defeated Yankees (29-13), 3-2 | Griffith Stadium (11-8) | 17-23 | |
| » Starters: Bob Turley vs Bob Porterfield | Sixth | 12 out |
| » Lost to Yankees (30-13), 5-3 | Griffith Stadium (11-9) | 17-24 | |
| » Starters: Tommy Byrne vs Johnny Schmitz | Sixth | 12 out |
| Wednesday, June 1 |
| » Lost to Tigers (23-20), 9-0 | Tiger Stadium (0-4) | 17-25 | Lost 2 |
| » Starters: Dean Stone vs Billy Hoeft | Sixth | 13½ out |
| Thursday, June 2 |
| » Lost to Tigers (24-20), 4-3 | Tiger Stadium (0-5) | 17-26 | Lost 3 |
| » Starters: Chuck Stobbs vs Steve Gromek | Sixth | 14½ out |
| Friday, June 3 |
| » Defeated Indians (29-16), 3-1 | Cleveland Stadium (1-2) | 18-26 | |
| » Starters: Mickey McDermott vs Bob Lemon | Fifth | 13½ out |
| Saturday, June 4 |
| » Defeated Indians (29-17), 14-5 | Cleveland Stadium (2-2) | 19-26 | Won 2 |
| » Starters: Bob Porterfield vs Mike Garcia | Fifth | 13½ out |
| Sunday, June 5 |
| » Defeated Indians (29-18), 6-4 | Cleveland Stadium (3-2) | 20-26 | Won 3 |
| » Starters: Johnny Schmitz vs Bob Feller | Fifth | 13½ out |
| » Lost to Indians (30-18), 6-3 | Cleveland Stadium (3-3) | 20-27 | |
| » Starters: Dean Stone vs Early Wynn | Fifth | 13½ out |
| Tuesday, June 7 |
| » Defeated Athletics (18-31), 3-2 | Municipal Stadium (2-1) | 21-27 | |
| » Starters: Camilo Pascual vs Alex Kellner | Fifth | 12½ out |
| » Defeated Athletics (18-32), 7-3 | Municipal Stadium (3-1) | 22-27 | Won 2 |
| » Starters: Mickey McDermott vs Art Ceccarelli | Fifth | 12½ out |
| Wednesday, June 8 |
| » Lost to Athletics (19-32), 3-2 | Municipal Stadium (3-2) | 22-28 | |
| » Starters: Bob Porterfield vs Cloyd Boyer | Fifth | 12½ out |
| Thursday, June 9 |
| » Lost to Athletics (20-32), 4-2 | Municipal Stadium (3-3) | 22-29 | Lost 2 |
| » Starters: Chuck Stobbs vs Art Ditmar | Sixth | 13½ out |
| Saturday, June 11 |
| » Lost to White Sox (30-19), 10-0 | Comiskey Park I (1-2) | 22-30 | Lost 3 |
| » Starters: Dean Stone vs Virgil Trucks | Sixth | 14 out |
| Sunday, June 12 |
| » Lost to White Sox (31-19), 1-0 | Comiskey Park I (1-3) | 22-31 | Lost 4 |
| » Starters: Bob Porterfield vs Billy Pierce | Sixth | 14 out |
| » Lost to White Sox (32-19), 8-4 | Comiskey Park I (1-4) | 22-32 | Lost 5 |
| » Starters: Johnny Schmitz vs Dick Donovan | Sixth | 14 out |
| Tuesday, June 14 |
| » Lost to Indians (34-22), 6-4 | Griffith Stadium (11-10) | 22-33 | Lost 6 |
| » Starters: Mike Garcia vs Camilo Pascual | Sixth | 15½ out |
| » Lost to Indians (35-22), 3-1 | Griffith Stadium (11-11) | 22-34 | Lost 7 |
| » Starters: Herb Score vs Mickey McDermott | Sixth | 15½ out |
| Wednesday, June 15 |
| » Defeated Indians (35-23), 7-0 | Griffith Stadium (12-11) | 23-34 | |
| » Starters: Bob Feller vs Dean Stone | Sixth | 14½ out |
| Thursday, June 16 |
| » Lost to Indians (36-23), 8-5 | Griffith Stadium (12-12) | 23-35 | |
| » Starters: Bob Lemon vs Chuck Stobbs | Sixth | 15½ out |
| Friday, June 17 |
| » Lost to Athletics (23-37), 4-2 | Griffith Stadium (12-13) | 23-36 | Lost 2 |
| » Starters: Arnie Portocarrero vs Bob Porterfield | Sixth | 15½ out |
| Saturday, June 18 |
| » Lost to Athletics (24-37), 9-4 | Griffith Stadium (12-14) | 23-37 | Lost 3 |
| » Starters: Vic Raschi vs Camilo Pascual | Seventh | 15½ out |
| Tuesday, June 21 |
| » Lost to White Sox (38-22), 6-1 | Griffith Stadium (12-15) | 23-38 | Lost 4 |
| » Starters: Virgil Trucks vs Bob Porterfield | Seventh | 17½ out |
| » Major-league debuts: Jose Valdivielso (Senators) |
| Wednesday, June 22 |
| » Lost to White Sox (39-22), 3-0 | Griffith Stadium (12-16) | 23-39 | Lost 5 |
| » Starters: Dick Donovan vs Dean Stone | Seventh | 18½ out |
| Thursday, June 23 |
| » Lost to White Sox (40-22), 7-0 | Griffith Stadium (12-17) | 23-40 | Lost 6 |
| » Starters: Harry Byrd vs Camilo Pascual | Seventh | 19½ out |
| Friday, June 24 |
| » Lost to Tigers (33-30), 18-7 | Griffith Stadium (12-18) | 23-41 | Lost 7 |
| » Starters: Billy Hoeft vs Bob Porterfield | Seventh | 20½ out |
| Saturday, June 25 |
| » Lost to Tigers (34-30), 4-0 | Griffith Stadium (12-19) | 23-42 | Lost 8 |
| » Starters: Steve Gromek vs Ted Abernathy | Seventh | 21½ out |
| Sunday, June 26 |
| » Lost to Tigers (35-30), 6-4 | Griffith Stadium (12-20) | 23-43 | Lost 9 |
| » Starters: Ned Garver vs Dean Stone | Seventh | 21½ out |
| » Defeated Tigers (35-31), 12-4 | Griffith Stadium (13-20) | 24-43 | |
| » Starters: Frank Lary vs Mickey McDermott | Seventh | 21½ out |
| Tuesday, June 28 |
| » Lost to Red Sox (37-34), 4-0 | Griffith Stadium (13-21) | 24-44 | |
| » Starters: Frank Sullivan vs Chuck Stobbs | Seventh | 22½ out |
| » Lost to Red Sox (38-34), 8-2 | Griffith Stadium (13-22) | 24-45 | Lost 2 |
| » Starters: Bill Henry vs Bob Porterfield | Seventh | 22½ out |
| Wednesday, June 29 |
| » Lost to Red Sox (39-34), 7-5 | Griffith Stadium (13-23) | 24-46 | Lost 3 |
| » Starters: Ike Delock vs Camilo Pascual | Seventh | 24 out |
| Former Senator Horace Milan dies in Texarkana, AR at the age of 62. |
| Thursday, June 30 |
| » Defeated Red Sox (39-35), 3-2 | Griffith Stadium (14-23) | 25-46 | |
| » Starters: Willard Nixon vs Ted Abernathy | Seventh | 23½ out |
| Friday, July 1 |
| » Lost to Yankees (51-24), 7-2 | Yankee Stadium (1-5) | 25-47 | |
| » Starters: Mickey McDermott vs Whitey Ford | Seventh | 24½ out |
| Saturday, July 2 |
| » Lost to Yankees (52-24), 12-0 | Yankee Stadium (1-6) | 25-48 | Lost 2 |
| » Starters: Bob Porterfield vs Tommy Byrne | Seventh | 25½ out |
| Sunday, July 3 |
| » Defeated Yankees (52-25), 5-0 | Yankee Stadium (2-6) | 26-48 | |
| » Starters: Johnny Schmitz vs Ed Lopat | Seventh | 24½ out |
| Monday, July 4 |
| » Lost to Orioles (21-53), 6-2 | Memorial Stadium (2-3) | 26-49 | |
| » Starters: Dean Stone vs Ray Moore | Seventh | 24 out |
| » Major-league debuts: Bob Hale (Orioles) |
| Wednesday, July 6 |
| » Lost to Red Sox (45-35), 7-5 | Fenway Park (1-3) | 26-50 | Lost 2 |
| » Starters: Ted Abernathy vs Tom Brewer | Seventh | 24 out |
| Thursday, July 7 |
| » Lost to Red Sox (46-35), 6-5 | Fenway Park (1-4) | 26-51 | Lost 3 |
| » Starters: Bob Porterfield vs Bill Henry | Seventh | 24½ out |
| Friday, July 8 |
| » Lost to Yankees (53-28), 3-0 | Griffith Stadium (14-24) | 26-52 | Lost 4 |
| » Starters: Tommy Byrne vs Camilo Pascual | Seventh | 25½ out |
| Saturday, July 9 |
| » Lost to Yankees (54-28), 4-0 | Griffith Stadium (14-25) | 26-53 | Lost 5 |
| » Starters: Bob Turley vs Johnny Schmitz | Seventh | 26½ out |
| Sunday, July 10 |
| » Defeated Yankees (54-29), 6-4 | Griffith Stadium (15-25) | 27-53 | |
| » Starters: Whitey Ford vs Dean Stone | Seventh | 26½ out |
| » Lost to Yankees (55-29), 8-3 | Griffith Stadium (15-26) | 27-54 | |
| » Starters: Ted Gray vs Ted Abernathy | Seventh | 26½ out |
| Thursday, July 14 |
| » Lost to White Sox (48-33), 13-4 | Comiskey Park I (1-5) | 27-55 | Lost 2 |
| » Starters: Camilo Pascual vs Connie Johnson | Seventh | 27 out |
| » Lost to White Sox (49-33), 5-2 | Comiskey Park I (1-6) | 27-56 | Lost 3 |
| » Starters: Ted Abernathy vs Dick Donovan | Seventh | 27 out |
| Friday, July 15 |
| » Lost to White Sox (50-33), 5-4 | Comiskey Park I (1-7) | 27-57 | Lost 4 |
| » Starters: Johnny Schmitz vs Virgil Trucks | Eighth | 28 out |
| Saturday, July 16 |
| » Defeated Athletics (36-50), 8-7 | Municipal Stadium (4-3) | 28-57 | |
| » Starters: Dean Stone vs Alex Kellner | Seventh | 26½ out |
| Sunday, July 17 |
| » Defeated Athletics (36-51), 4-0 | Municipal Stadium (5-3) | 29-57 | Won 2 |
| » Starters: Spec Shea vs Vic Raschi | Seventh | 25½ out |
| Monday, July 18 |
| » Defeated Athletics (36-52), 6-3 | Municipal Stadium (6-3) | 30-57 | Won 3 |
| » Starters: Ted Abernathy vs Cloyd Boyer | Seventh | 25 out |
| Tuesday, July 19 |
| » Defeated Indians (53-37), 8-1 | Cleveland Stadium (4-3) | 31-57 | Won 4 |
| » Starters: Dean Stone vs Bob Lemon | Seventh | 25 out |
| Wednesday, July 20 |
| » Defeated Indians (53-38), 6-4 | Cleveland Stadium (5-3) | 32-57 | Won 5 |
| » Starters: Chuck Stobbs vs Early Wynn | Seventh | 24 out |
| Thursday, July 21 |
| » Lost to Indians (54-38), 4-3 | Cleveland Stadium (5-4) | 32-58 | |
| » Starters: Johnny Schmitz vs Art Houtteman | Seventh | 24 out |
| Friday, July 22 |
| » Lost to Tigers (48-42), 11-3 | Tiger Stadium (0-6) | 32-59 | Lost 2 |
| » Starters: Camilo Pascual vs Ned Garver | Seventh | 24 out |
| Saturday, July 23 |
| » Lost to Tigers (49-42), 10-4 | Tiger Stadium (0-7) | 32-60 | Lost 3 |
| » Starters: Dean Stone vs Steve Gromek | Seventh | 24 out |
| Sunday, July 24 |
| » Lost to Tigers (50-42), 7-3 | Tiger Stadium (0-8) | 32-61 | Lost 4 |
| » Starters: Pedro Ramos vs Jim Bunning | Seventh | 25 out |
| » Defeated Tigers (50-43), 3-0 | Tiger Stadium (1-8) | 33-61 | |
| » Starters: Ted Abernathy vs Frank Lary | Seventh | 25 out |
| Tuesday, July 26 |
| » Defeated Athletics (38-58), 9-3 | Griffith Stadium (16-26) | 34-61 | Won 2 |
| » Starters: Cloyd Boyer vs Bob Porterfield | Seventh | 25½ out |
| » Lost to Athletics (39-58), 3-1 | Griffith Stadium (16-27) | 34-62 | |
| » Starters: Alex Kellner vs Spec Shea | Seventh | 25½ out |
| Wednesday, July 27 |
| » Lost to Athletics (40-58), 6-4 | Griffith Stadium (16-28) | 34-63 | Lost 2 |
| » Starters: Bobby Shantz vs Dean Stone | Seventh | 26 out |
| » Lost to Athletics (41-58), 4-1 | Griffith Stadium (16-29) | 34-64 | Lost 3 |
| » Starters: Ray Herbert vs Johnny Schmitz | Seventh | 26 out |
| Friday, July 29 |
| » Lost to White Sox (60-38), 5-2 | Griffith Stadium (16-30) | 34-65 | Lost 4 |
| » Starters: Virgil Trucks vs Pedro Ramos | Seventh | 26½ out |
| Saturday, July 30 |
| » Defeated White Sox (60-39), 1-0 | Griffith Stadium (17-30) | 35-65 | |
| » Starters: Billy Pierce vs Bob Porterfield | Sixth | 25½ out |
| Sunday, July 31 |
| » Lost to White Sox (61-39), 3-1 | Griffith Stadium (17-31) | 35-66 | |
| » Starters: Jack Harshman vs Mickey McDermott | Sixth | 27½ out |
| » Lost to White Sox (62-39), 6-5 | Griffith Stadium (17-32) | 35-67 | Lost 2 |
| » Starters: Harry Byrd vs Spec Shea | Sixth | 27½ out |
| Tuesday, August 2 |
| » Lost to Tigers (56-47), 13-10 | Griffith Stadium (17-33) | 35-68 | Lost 3 |
| » Starters: Steve Gromek vs Johnny Schmitz | Seventh | 28½ out |
| Wednesday, August 3 |
| » Lost to Tigers (57-47), 3-0 | Griffith Stadium (17-34) | 35-69 | Lost 4 |
| » Starters: Frank Lary vs Bob Porterfield | Sixth | 28½ out |
| Thursday, August 4 |
| » Defeated Tigers (57-48), 9-6 | Griffith Stadium (18-34) | 36-69 | |
| » Starters: Ned Garver vs Ted Abernathy | Seventh | 27½ out |
| Friday, August 5 |
| » Defeated Indians (64-43), 7-5 | Griffith Stadium (19-34) | 37-69 | Won 2 |
| » Starters: Sal Maglie vs Dean Stone | Sixth | 26½ out |
| Saturday, August 6 |
| » Defeated Indians (64-44), 6-5 | Griffith Stadium (20-34) | 38-69 | Won 3 |
| » Starters: Art Houtteman vs Camilo Pascual | Sixth | 25½ out |
| Sunday, August 7 |
| » Defeated Indians (64-45), 9-3 | Griffith Stadium (21-34) | 39-69 | Won 4 |
| » Starters: Early Wynn vs Johnny Schmitz | Seventh | 25 out |
| Tuesday, August 9 |
| » Lost to Orioles (36-72), 1-0 | Memorial Stadium (2-4) | 39-70 | |
| » Starters: Dean Stone vs Bill Wight | Seventh | 25½ out |
| » Defeated Orioles (36-73), 6-3 | Memorial Stadium (3-4) | 40-70 | |
| » Starters: Chuck Stobbs vs Jim Wilson | Seventh | 25½ out |
| Saturday, August 13 |
| » Defeated Red Sox (64-49), 18-9 | Fenway Park (2-4) | 41-70 | Won 2 |
| » Starters: Bob Porterfield vs Willard Nixon | Seventh | 27 out |
| » Major-league debuts: Jim Pagliaroni (Red Sox) |
| Sunday, August 14 |
| » Lost to Red Sox (65-49), 9-6 | Fenway Park (2-5) | 41-71 | |
| » Starters: Spec Shea vs Tom Brewer | Seventh | 27½ out |
| » Lost to Red Sox (66-49), 2-1 | Fenway Park (2-6) | 41-72 | Lost 2 |
| » Starters: Pedro Ramos vs George Susce | Seventh | 27½ out |
| Monday, August 15 |
| » Lost to Red Sox (67-49), 8-4 | Fenway Park (2-7) | 41-73 | Lost 3 |
| » Starters: Ted Abernathy vs Mel Parnell | Seventh | 28½ out |
| Tuesday, August 16 |
| » Lost to Orioles (37-77), 7-2 | Griffith Stadium (21-35) | 41-74 | Lost 4 |
| » Starters: Erv Palica vs Johnny Schmitz | Seventh | 29½ out |
| Friday, August 19 |
| » Lost to Red Sox (69-50), 8-0 | Griffith Stadium (21-36) | 41-75 | Lost 5 |
| » Starters: Frank Sullivan vs Bob Porterfield | Seventh | 30 out |
| Saturday, August 20 |
| » Defeated Red Sox (69-51), 6-2 | Griffith Stadium (22-36) | 42-75 | |
| » Starters: Willard Nixon vs Pedro Ramos | Seventh | 30 out |
| Sunday, August 21 |
| » Lost to Red Sox (70-51), 4-1 | Griffith Stadium (22-37) | 42-76 | |
| » Starters: George Susce vs Chuck Stobbs | Seventh | 31 out |
| Tuesday, August 23 |
| » Lost to Athletics (50-74), 4-3 | Municipal Stadium (6-4) | 42-77 | Lost 2 |
| » Starters: Dean Stone vs Alex Kellner | Seventh | 31 out |
| Wednesday, August 24 |
| » Lost to Athletics (51-74), 5-0 | Municipal Stadium (6-5) | 42-78 | Lost 3 |
| » Starters: Ted Abernathy vs Arnie Portocarrero | Seventh | 32 out |
| Thursday, August 25 |
| » Defeated White Sox (75-49), 6-1 | Comiskey Park I (2-7) | 43-78 | |
| » Starters: Bob Porterfield vs Connie Johnson | Seventh | 32 out |
| Friday, August 26 |
| » Defeated White Sox (75-50), 10-0 | Comiskey Park I (3-7) | 44-78 | Won 2 |
| » Starters: Pedro Ramos vs Dick Donovan | Seventh | 31 out |
| Saturday, August 27 |
| » Lost to White Sox (76-50), 11-1 | Comiskey Park I (3-8) | 44-79 | |
| » Starters: Camilo Pascual vs Jack Harshman | Sixth | 31 out |
| Sunday, August 28 |
| » Defeated Indians (77-51), 8-2 | Cleveland Stadium (6-4) | 45-79 | |
| » Starters: Dean Stone vs Art Houtteman | Seventh | 30 out |
| » Defeated Indians (77-52), 13-4 | Cleveland Stadium (7-4) | 46-79 | Won 2 |
| » Starters: Mickey McDermott vs Mike Garcia | Seventh | 30 out |
| Tuesday, August 30 |
| » Lost to Tigers (66-65), 4-0 | Tiger Stadium (1-9) | 46-80 | |
| » Starters: Pedro Ramos vs Billy Hoeft | Sixth | 30½ out |
| Wednesday, August 31 |
| » Lost to Tigers (67-65), 7-4 | Tiger Stadium (1-10) | 46-81 | Lost 2 |
| » Starters: Johnny Schmitz vs Frank Lary | Sixth | 31½ out |
| Friday, September 2 |
| » Lost to Yankees (80-52), 4-2 | Yankee Stadium (2-7) | 46-82 | Lost 3 |
| » Starters: Bob Porterfield vs Whitey Ford | Seventh | 32½ out |
| Saturday, September 3 |
| » Defeated Yankees (80-53), 10-5 | Yankee Stadium (3-7) | 47-82 | |
| » Starters: Camilo Pascual vs Don Larsen | Sixth | 31½ out |
| Sunday, September 4 |
| » Lost to Yankees (81-53), 8-3 | Yankee Stadium (3-8) | 47-83 | |
| » Starters: Pedro Ramos vs Bob Turley | Seventh | 32½ out |
| Monday, September 5 |
| » Lost to Red Sox (78-56), 10-2 | Fenway Park (2-8) | 47-84 | Lost 2 |
| » Starters: Ted Abernathy vs Tom Brewer | Seventh | 33½ out |
| » Lost to Red Sox (79-56), 7-2 | Fenway Park (2-9) | 47-85 | Lost 3 |
| » Starters: Mickey McDermott vs George Susce | Seventh | 33½ out |
| Wednesday, September 7 |
| » Lost to White Sox (82-55), 4-3 | Griffith Stadium (22-38) | 47-86 | Lost 4 |
| » Starters: Jack Harshman vs Pedro Ramos | Seventh | 34½ out |
| Thursday, September 8 |
| » Defeated White Sox (82-56), 5-4 | Griffith Stadium (23-38) | 48-86 | |
| » Starters: Virgil Trucks vs Chuck Stobbs | Seventh | 34½ out |
| Friday, September 9 |
| » Defeated Athletics (56-82), 6-5 | Griffith Stadium (24-38) | 49-86 | Won 2 |
| » Starters: Alex Kellner vs Mickey McDermott | Seventh | 35 out |
| » Lost to Athletics (57-82), 7-6 | Griffith Stadium (24-39) | 49-87 | |
| » Starters: Gus Keriazakos vs Dean Stone | Seventh | 35 out |
| Saturday, September 10 |
| » Lost to Athletics (58-82), 8-6 | Griffith Stadium (24-40) | 49-88 | Lost 2 |
| » Starters: Johnny Gray vs Webbo Clarke | Seventh | 36 out |
| Sunday, September 11 |
| » Lost to Tigers (72-70), 8-0 | Griffith Stadium (24-41) | 49-89 | Lost 3 |
| » Starters: Billy Hoeft vs Johnny Schmitz | Seventh | 36 out |
| » Defeated Tigers (72-71), 1-0 | Griffith Stadium (25-41) | 50-89 | |
| » Starters: Frank Lary vs Ted Abernathy | Seventh | 36 out |
| Tuesday, September 13 |
| » Lost to Indians (89-55), 3-1 | Griffith Stadium (25-42) | 50-90 | |
| » Starters: Mike Garcia vs Chuck Stobbs | Seventh | 38 out |
| » Lost to Indians (90-55), 8-2 | Griffith Stadium (25-43) | 50-91 | Lost 2 |
| » Starters: Bob Lemon vs Bob Porterfield | Seventh | 38 out |
| » Major-league debuts: Julio Becquer (Senators) |
| Wednesday, September 14 |
| » Defeated Indians (90-56), 3-2 | Griffith Stadium (26-43) | 51-91 | |
| » Starters: Herb Score vs Mickey McDermott | Seventh | 37 out |
| Friday, September 16 |
| » Lost to Orioles (48-95), 5-4 | Memorial Stadium (3-5) | 51-92 | |
| » Starters: Ted Abernathy vs Art Schallock | Seventh | 37½ out |
| » Lost to Orioles (49-95), 8-7 | Memorial Stadium (3-6) | 51-93 | Lost 2 |
| » Starters: Webbo Clarke vs Hal Brown | Seventh | 37½ out |
| Saturday, September 17 |
| » Lost to Orioles (50-95), 3-1 | Memorial Stadium (3-7) | 51-94 | Lost 3 |
| » Starters: Chuck Stobbs vs Ed Lopat | Seventh | 38½ out |
| » Major-league debuts: Brooks Robinson (Orioles) |
| Sunday, September 18 |
| » Lost to Orioles (51-95), 9-0 | Memorial Stadium (3-8) | 51-95 | Lost 4 |
| » Starters: Johnny Schmitz vs Jim Wilson | Seventh | 39½ out |
| Tuesday, September 20 |
| » Lost to Yankees (92-56), 6-3 | Griffith Stadium (26-44) | 51-96 | Lost 5 |
| » Starters: Don Larsen vs Mickey McDermott | Eighth | 41½ out |
| » Lost to Yankees (93-56), 9-7 | Griffith Stadium (26-45) | 51-97 | Lost 6 |
| » Starters: Whitey Ford vs Pedro Ramos | Eighth | 41½ out |
| Wednesday, September 21 |
| » Lost to Yankees (94-56), 7-3 | Griffith Stadium (26-46) | 51-98 | Lost 7 |
| » Starters: Bob Turley vs Chuck Stobbs | Eighth | 42½ out |
| Friday, September 23 |
| » Defeated Orioles (54-96), 6-4 | Griffith Stadium (27-46) | 52-98 | |
| » Starters: Jim Wilson vs Mickey McDermott | Eighth | 41½ out |
| » Defeated Orioles (54-97), 7-3 | Griffith Stadium (28-46) | 53-98 | Won 2 |
| » Starters: Ed Lopat vs Johnny Schmitz | Eighth | 41½ out |
| Saturday, September 24 |
| » Lost to Orioles (55-97), 8-5 | Griffith Stadium (28-47) | 53-99 | |
| » Starters: Ray Moore vs Ted Abernathy | Eighth | 42½ out |
| » Lost to Orioles (56-97), 1-0 | Griffith Stadium (28-48) | 53-100 | Lost 2 |
| » Starters: Bill Wight vs Dean Stone | Eighth | 42½ out |
| Sunday, September 25 |
| » Lost to Orioles (57-97), 5-4 | Griffith Stadium (28-49) | 53-101 | Lost 3 |
| » Starters: Erv Palica vs Bunky Stewart | Eighth | 43 out |
| Tuesday, October 18 |
| Former Senator George Murray dies in Memphis, TN at the age of 58. |
| Thursday, October 27 |
| Former Senator Clark Griffith dies in Washington, DC at the age of 86. |
| Saturday, November 12 |
| Former Senator Sam Crane dies in Philadelphia, PA at the age of 62. |
| Wednesday, November 30 |
| Former Senator John Stone dies in Shelbyville, TN at the age of 51. |
Game information provided by Retrosheet (www.retrosheet.org) |
