| Thursday, January 13 |
| Former Red Sox Bill Dineen dies in Syracuse, NY at the age of 79. |
| Friday, January 21 |
| Future Red Sox Mike Smithson is born in Centerville, TN. |
| Monday, January 24 |
| Future Red Sox Ted Cox is born in Oklahoma City, OK. |
| Friday, February 4 |
| Future Red Sox Gary Allenson is born in Culver City, CA. |
| Sunday, February 6 |
| Former Red Sox Hank Thormahlen dies in Los Angeles, CA at the age of 59. |
| Monday, April 11 |
| » Major-league debuts: Ernie Oravetz and Pedro Ramos (Senators) Don Ferrarese and Don Leppert (Orioles) |
| Tuesday, April 12 |
| » Defeated Orioles (0-2), 7-1 | Memorial Stadium (1-0) | 1-0 | |
| » Starters: Frank Sullivan vs Joe Coleman | First | -- |
| Wednesday, April 13 |
| » Major-league debuts: Ted Abernathy (Senators) |
| Thursday, April 14 |
| » Defeated Yankees (1-1), 8-4 | Fenway Park (1-0) | 2-0 | Won 2 |
| » Starters: Bob Grim vs Willard Nixon | First | -- |
| » Major-league debuts: Elston Howard (Yankees) |
| Friday, April 15 |
| » Lost to Yankees (2-1), 6-4 | Fenway Park (1-1) | 2-1 | |
| » Starters: Bob Turley vs Tom Brewer | Second | 1 out |
| » Major-league debuts: George Susce (Red Sox) |
| Saturday, April 16 |
| » Defeated Orioles (0-3), 6-5 | Fenway Park (2-1) | 3-1 | |
| » Starters: Erv Palica vs Ike Delock | First | -- |
| Future Red Sox Rick Jones is born in Jacksonville, FL. |
| Sunday, April 17 |
| » Defeated Orioles (0-4), 14-5 | Fenway Park (3-1) | 4-1 | Won 2 |
| » Starters: Saul Rogovin vs Frank Sullivan | First | -- |
| » Defeated Orioles (0-5), 12-9 | Fenway Park (4-1) | 5-1 | Won 3 |
| » Starters: Lou Kretlow vs Russ Kemmerer | First | -- |
| » Major-league debuts: Jim Pyburn (Orioles) |
| Wednesday, April 20 |
| » Defeated Senators (2-3), 1-0 | Griffith Stadium (1-0) | 6-1 | Won 4 |
| » Starters: Willard Nixon vs Chuck Stobbs | First | -- |
| Thursday, April 21 |
| » Lost to Senators (3-3), 1-0 | Griffith Stadium (1-1) | 6-2 | |
| » Starters: Tom Brewer vs Bob Porterfield | First | -- |
| Friday, April 22 |
| » Lost to Yankees (6-3), 3-0 | Yankee Stadium (0-1) | 6-3 | Lost 2 |
| » Starters: Frank Sullivan vs Whitey Ford | Second | 1 out |
| Saturday, April 23 |
| » Lost to Yankees (7-3), 7-2 | Yankee Stadium (0-2) | 6-4 | Lost 3 |
| » Starters: Ike Delock vs Johnny Kucks | Third | 1 out |
| Sunday, April 24 |
| » Defeated Yankees (7-4), 1-0 | Yankee Stadium (1-2) | 7-4 | |
| » Starters: Willard Nixon vs Ed Lopat | Second | 1 out |
| Tuesday, April 26 |
| » Lost to Athletics (4-7), 8-7 | Municipal Stadium (0-1) | 7-5 | |
| » Starters: Tom Brewer vs Arnie Portocarrero | Third | 1 out |
| Wednesday, April 27 |
| » Lost to Athletics (5-7), 6-2 | Municipal Stadium (0-2) | 7-6 | Lost 2 |
| » Starters: Frank Sullivan vs Cloyd Boyer | Fourth | 1 out |
| Thursday, April 28 |
| » Defeated White Sox (7-5), 3-1 | Comiskey Park I (1-0) | 8-6 | |
| » Starters: Ike Delock vs Jack Harshman | Fourth | 1 out |
| Friday, April 29 |
| » Lost to White Sox (8-5), 7-0 | Comiskey Park I (1-1) | 8-7 | |
| » Starters: Willard Nixon vs Dick Donovan | Fifth | 1½ out |
| » Major-league debuts: Bob Smith and Joe Trimble (Red Sox) |
| Saturday, April 30 |
| » Lost to White Sox (9-5), 3-1 | Comiskey Park I (1-2) | 8-8 | Lost 2 |
| » Starters: George Susce vs Sandy Consuegra | Fourth | 2½ out |
| Sunday, May 1 |
| » Lost to Indians (10-6), 2-0 | Cleveland Stadium (0-1) | 8-9 | Lost 3 |
| » Starters: Frank Sullivan vs Bob Feller | Fourth | 3½ out |
| » Lost to Indians (11-6), 2-1 | Cleveland Stadium (0-2) | 8-10 | Lost 4 |
| » Starters: Tom Brewer vs Herb Score | Fourth | 3½ out |
| Monday, May 2 |
| » Lost to Indians (12-6), 4-2 | Cleveland Stadium (0-3) | 8-11 | Lost 5 |
| » Starters: Russ Kemmerer vs Early Wynn | Sixth | 4½ out |
| Tuesday, May 3 |
| » Lost to Tigers (12-6), 4-2 | Tiger Stadium (0-1) | 8-12 | Lost 6 |
| » Starters: Ike Delock vs Billy Hoeft | Sixth | 5½ out |
| » Major-league debuts: Pete Daley (Red Sox) |
| Wednesday, May 4 |
| » Defeated Tigers (12-7), 3-2 | Tiger Stadium (1-1) | 9-12 | |
| » Starters: Willard Nixon vs Frank Lary | Sixth | 4½ out |
| Thursday, May 5 |
| » Lost to Tigers (13-7), 3-2 | Tiger Stadium (1-2) | 9-13 | |
| » Starters: Tom Brewer vs Duke Maas | Fifth | 5 out |
| Friday, May 6 |
| » Lost to Yankees (12-8), 6-0 | Fenway Park (4-2) | 9-14 | Lost 2 |
| » Starters: Bob Turley vs Frank Sullivan | Seventh | 6 out |
| Saturday, May 7 |
| » Lost to Yankees (13-8), 9-6 | Fenway Park (4-3) | 9-15 | Lost 3 |
| » Starters: Don Larsen vs Leo Kiely | Seventh | 7 out |
| » Major-league debuts: Tommy Carroll (Yankees) |
| Sunday, May 8 |
| » Lost to Yankees (14-8), 5-0 | Fenway Park (4-4) | 9-16 | Lost 4 |
| » Starters: Bob Grim vs Willard Nixon | Sixth | 8½ out |
| Tuesday, May 10 |
| » Lost to White Sox (15-8), 4-2 | Fenway Park (4-5) | 9-17 | Lost 5 |
| » Starters: Bob Keegan vs Tom Brewer | Seventh | 9½ out |
| Wednesday, May 11 |
| » Defeated White Sox (15-9), 4-3 | Fenway Park (5-5) | 10-17 | |
| » Starters: Virgil Trucks vs Frank Sullivan | Seventh | 9½ out |
| Thursday, May 12 |
| » Defeated Athletics (10-15), 12-7 | Fenway Park (6-5) | 11-17 | Won 2 |
| » Starters: Vic Raschi vs Ike Delock | Seventh | 8½ out |
| Friday, May 13 |
| » Defeated Athletics (10-16), 4-3 | Fenway Park (7-5) | 12-17 | Won 3 |
| » Starters: Art Ceccarelli vs Willard Nixon | Sixth | 8 out |
| Saturday, May 14 |
| » Defeated Athletics (10-17), 3-1 | Fenway Park (8-5) | 13-17 | Won 4 |
| » Starters: Art Ditmar vs Leo Kiely | Fifth | 7½ out |
| Sunday, May 15 |
| » Defeated Tigers (15-14), 10-4 | Fenway Park (9-5) | 14-17 | Won 5 |
| » Starters: Frank Lary vs Frank Sullivan | Fifth | 7½ out |
| » Lost to Tigers (16-14), 9-3 | Fenway Park (9-6) | 14-18 | |
| » Starters: Duke Maas vs Tom Brewer | Fifth | 7½ out |
| Tuesday, May 17 |
| » Defeated Indians (20-10), 10-3 | Fenway Park (10-6) | 15-18 | |
| » Starters: Early Wynn vs Bill Henry | Fifth | 6½ out |
| Wednesday, May 18 |
| » Lost to Indians (21-10), 19-0 | Fenway Park (10-7) | 15-19 | |
| » Starters: Herb Score vs Willard Nixon | Fifth | 7½ out |
| Friday, May 20 |
| » Lost to Senators (13-18), 3-1 | Griffith Stadium (1-2) | 15-20 | Lost 2 |
| » Starters: Frank Sullivan vs Bob Porterfield | Fifth | 7½ out |
| Saturday, May 21 |
| » Lost to Senators (14-18), 1-0 | Griffith Stadium (1-3) | 15-21 | Lost 3 |
| » Starters: Tom Brewer vs Camilo Pascual | Sixth | 8 out |
| Tuesday, May 24 |
| » Lost to Orioles (11-25), 6-1 | Memorial Stadium (1-1) | 15-22 | Lost 4 |
| » Starters: Willard Nixon vs Jim McDonald | Sixth | 9 out |
| Wednesday, May 25 |
| » Lost to Orioles (12-25), 6-2 | Memorial Stadium (1-2) | 15-23 | Lost 5 |
| » Starters: Frank Sullivan vs Harry Byrd | Sixth | 9½ out |
| » Defeated Orioles (12-26), 5-2 | Memorial Stadium (2-2) | 16-23 | |
| » Starters: Ike Delock vs Don Johnson | Sixth | 9½ out |
| Thursday, May 26 |
| » Lost to Orioles (13-26), 2-0 | Memorial Stadium (2-3) | 16-24 | |
| » Starters: Leo Kiely vs Jim Wilson | Sixth | 11 out |
| Friday, May 27 |
| » Defeated Senators (15-22), 16-0 | Fenway Park (11-7) | 17-24 | |
| » Starters: Bob Porterfield vs Tom Brewer | Fifth | 11 out |
| Saturday, May 28 |
| » Lost to Senators (16-22), 5-3 | Fenway Park (11-8) | 17-25 | |
| » Starters: Camilo Pascual vs Bill Henry | Sixth | 12 out |
| Sunday, May 29 |
| » Defeated Senators (16-23), 12-7 | Fenway Park (12-8) | 18-25 | |
| » Starters: Chuck Stobbs vs Willard Nixon | Fifth | 12 out |
| Monday, May 30 |
| » Lost to Orioles (14-29), 8-6 | Fenway Park (12-9) | 18-26 | |
| » Starters: Harry Byrd vs Frank Sullivan | Fifth | 12 out |
| » Defeated Orioles (14-30), 8-1 | Fenway Park (13-9) | 19-26 | |
| » Starters: Jim McDonald vs Ike Delock | Fifth | 12 out |
| Wednesday, June 1 |
| » Lost to White Sox (26-16), 4-3 | Comiskey Park I (1-3) | 19-27 | |
| » Starters: Tom Brewer vs Dick Donovan | Fifth | 13½ out |
| Thursday, June 2 |
| » Lost to White Sox (27-16), 4-2 | Comiskey Park I (1-4) | 19-28 | Lost 2 |
| » Starters: Mel Parnell vs Virgil Trucks | Fifth | 14½ out |
| Friday, June 3 |
| » Lost to Athletics (17-28), 4-3 | Municipal Stadium (0-3) | 19-29 | Lost 3 |
| » Starters: Ike Delock vs Bobby Shantz | Sixth | 14½ out |
| Saturday, June 4 |
| » Defeated Athletics (17-29), 5-1 | Municipal Stadium (1-3) | 20-29 | |
| » Starters: Frank Sullivan vs Art Ditmar | Sixth | 14½ out |
| Sunday, June 5 |
| » Lost to Athletics (18-29), 5-4 | Municipal Stadium (1-4) | 20-30 | |
| » Starters: Willard Nixon vs Vic Raschi | Sixth | 14½ out |
| » Defeated Athletics (18-30), 4-3 | Municipal Stadium (2-4) | 21-30 | |
| » Starters: Tom Brewer vs Ray Herbert | Sixth | 14½ out |
| Tuesday, June 7 |
| » Defeated Indians (30-19), 9-5 | Cleveland Stadium (1-3) | 22-30 | Won 2 |
| » Starters: Mel Parnell vs Herb Score | Sixth | 14 out |
| Wednesday, June 8 |
| » Defeated Indians (30-20), 5-4 | Cleveland Stadium (2-3) | 23-30 | Won 3 |
| » Starters: Bill Henry vs Bob Lemon | Sixth | 13 out |
| Thursday, June 9 |
| » Defeated Indians (30-21), 4-2 | Cleveland Stadium (3-3) | 24-30 | Won 4 |
| » Starters: Frank Sullivan vs Herb Score | Fifth | 13 out |
| Friday, June 10 |
| » Defeated Tigers (29-24), 5-2 | Tiger Stadium (2-2) | 25-30 | Won 5 |
| » Starters: Willard Nixon vs Duke Maas | Fifth | 13 out |
| Saturday, June 11 |
| » Lost to Tigers (30-24), 7-5 | Tiger Stadium (2-3) | 25-31 | |
| » Starters: Tom Brewer vs Billy Hoeft | Fifth | 13 out |
| Tuesday, June 14 |
| » Defeated Athletics (22-35), 12-4 | Fenway Park (14-9) | 26-31 | |
| » Starters: Art Ditmar vs Frank Sullivan | Fifth | 12 out |
| Wednesday, June 15 |
| » Defeated Athletics (22-36), 9-6 | Fenway Park (15-9) | 27-31 | Won 2 |
| » Starters: Ray Herbert vs Mel Parnell | Fifth | 11 out |
| Thursday, June 16 |
| » Defeated Athletics (22-37), 7-6 | Fenway Park (16-9) | 28-31 | Won 3 |
| » Starters: Cloyd Boyer vs Willard Nixon | Fifth | 11 out |
| Friday, June 17 |
| » Defeated Indians (36-24), 6-5 | Fenway Park (17-9) | 29-31 | Won 4 |
| » Starters: Early Wynn vs Tom Brewer | Fifth | 10½ out |
| » Lost to Indians (37-24), 3-2 | Fenway Park (17-10) | 29-32 | |
| » Starters: Ray Narleski vs George Susce | Fifth | 10½ out |
| Saturday, June 18 |
| » Defeated Indians (37-25), 4-2 | Fenway Park (18-10) | 30-32 | |
| » Starters: Mike Garcia vs Frank Sullivan | Fifth | 9½ out |
| Sunday, June 19 |
| » Defeated Indians (37-26), 11-7 | Fenway Park (19-10) | 31-32 | Won 2 |
| » Starters: Herb Score vs Mel Parnell | Fifth | 10 out |
| Tuesday, June 21 |
| » Defeated Tigers (32-28), 5-4 | Fenway Park (20-10) | 32-32 | Won 3 |
| » Starters: Ned Garver vs Willard Nixon | Fifth | 10 out |
| Wednesday, June 22 |
| » Defeated Tigers (32-29), 12-7 | Fenway Park (21-10) | 33-32 | Won 4 |
| » Starters: Frank Lary vs Tom Brewer | Fifth | 10 out |
| Former Red Sox Frankie Hayes dies in Point Pleasant, NJ at the age of 41. |
| Thursday, June 23 |
| » Defeated Tigers (32-30), 7-0 | Fenway Park (22-10) | 34-32 | Won 5 |
| » Starters: Duke Maas vs Frank Sullivan | Fifth | 10 out |
| Friday, June 24 |
| » Lost to White Sox (41-22), 3-2 | Fenway Park (22-11) | 34-33 | |
| » Starters: Billy Pierce vs Mel Parnell | Fifth | 11 out |
| Saturday, June 25 |
| » Lost to White Sox (42-22), 8-3 | Fenway Park (22-12) | 34-34 | Lost 2 |
| » Starters: Jack Harshman vs George Susce | Fifth | 12 out |
| Sunday, June 26 |
| » Defeated White Sox (42-23), 5-2 | Fenway Park (23-12) | 35-34 | |
| » Starters: Virgil Trucks vs Willard Nixon | Fifth | 11 out |
| » Defeated White Sox (42-24), 8-2 | Fenway Park (24-12) | 36-34 | Won 2 |
| » Starters: Bob Keegan vs Tom Brewer | Fifth | 11 out |
| Monday, June 27 |
| Former Red Sox Harry Agganis dies in Cambridge, MA at the age of 27. |
| Tuesday, June 28 |
| » Defeated Senators (24-44), 4-0 | Griffith Stadium (2-3) | 37-34 | Won 3 |
| » Starters: Frank Sullivan vs Chuck Stobbs | Fifth | 10 out |
| » Defeated Senators (24-45), 8-2 | Griffith Stadium (3-3) | 38-34 | Won 4 |
| » Starters: Bill Henry vs Bob Porterfield | Fifth | 10 out |
| Wednesday, June 29 |
| » Defeated Senators (24-46), 7-5 | Griffith Stadium (4-3) | 39-34 | Won 5 |
| » Starters: Ike Delock vs Camilo Pascual | Fifth | 10½ out |
| Thursday, June 30 |
| » Lost to Senators (25-46), 3-2 | Griffith Stadium (4-4) | 39-35 | |
| » Starters: Willard Nixon vs Ted Abernathy | Fifth | 11 out |
| Friday, July 1 |
| » Defeated Orioles (20-51), 4-3 | Memorial Stadium (3-3) | 40-35 | |
| » Starters: Tom Brewer vs Jim Wilson | Fifth | 11 out |
| Saturday, July 2 |
| » Defeated Orioles (20-52), 5-1 | Memorial Stadium (4-3) | 41-35 | Won 2 |
| » Starters: George Susce vs Don Johnson | Fourth | 11 out |
| Sunday, July 3 |
| » Defeated Orioles (20-53), 7-2 | Memorial Stadium (5-3) | 42-35 | Won 3 |
| » Starters: Frank Sullivan vs Jim McDonald | Fourth | 10 out |
| Monday, July 4 |
| » Defeated Yankees (52-26), 4-2 | Yankee Stadium (2-2) | 43-35 | Won 4 |
| » Starters: Willard Nixon vs Bob Turley | Fourth | 8 out |
| » Defeated Yankees (52-27), 10-5 | Yankee Stadium (3-2) | 44-35 | Won 5 |
| » Starters: Mel Parnell vs Tom Morgan | Fourth | 8 out |
| Wednesday, July 6 |
| » Defeated Senators (26-50), 7-5 | Fenway Park (25-12) | 45-35 | Won 6 |
| » Starters: Ted Abernathy vs Tom Brewer | Fourth | 7 out |
| Thursday, July 7 |
| » Defeated Senators (26-51), 6-5 | Fenway Park (26-12) | 46-35 | Won 7 |
| » Starters: Bob Porterfield vs Bill Henry | Fourth | 6½ out |
| Friday, July 8 |
| » Lost to Orioles (23-53), 9-3 | Fenway Park (26-13) | 46-36 | |
| » Starters: Duane Pillette vs Frank Sullivan | Fourth | 7½ out |
| Saturday, July 9 |
| » Defeated Orioles (23-54), 5-4 | Fenway Park (27-13) | 47-36 | |
| » Starters: Erv Palica vs Ike Delock | Fourth | 7½ out |
| Sunday, July 10 |
| » Defeated Orioles (23-55), 10-7 | Fenway Park (28-13) | 48-36 | Won 2 |
| » Starters: Jim McDonald vs Willard Nixon | Fourth | 7 out |
| Thursday, July 14 |
| » Lost to Tigers (42-40), 6-0 | Tiger Stadium (2-4) | 48-37 | |
| » Starters: Ike Delock vs Frank Lary | Fourth | 6½ out |
| » Defeated Tigers (42-41), 7-3 | Tiger Stadium (3-4) | 49-37 | |
| » Starters: George Susce vs Duke Maas | Fourth | 6½ out |
| Saturday, July 16 |
| » Lost to Indians (52-35), 4-1 | Cleveland Stadium (3-4) | 49-38 | |
| » Starters: Frank Sullivan vs Art Houtteman | Fourth | 6½ out |
| Sunday, July 17 |
| » Defeated Indians (52-36), 6-0 | Cleveland Stadium (4-4) | 50-38 | |
| » Starters: Tom Brewer vs Herb Score | Fourth | 6 out |
| » Lost to Indians (53-36), 6-5 | Cleveland Stadium (4-5) | 50-39 | |
| » Starters: Bill Henry vs Mike Garcia | Fourth | 6 out |
| Tuesday, July 19 |
| » Defeated Athletics (36-53), 6-3 | Municipal Stadium (3-4) | 51-39 | |
| » Starters: Willard Nixon vs Art Ditmar | Fourth | 6 out |
| Wednesday, July 20 |
| » Defeated Athletics (36-54), 6-0 | Municipal Stadium (4-4) | 52-39 | Won 2 |
| » Starters: George Susce vs Arnie Portocarrero | Fourth | 5 out |
| Thursday, July 21 |
| » Defeated Athletics (36-55), 4-3 | Municipal Stadium (5-4) | 53-39 | Won 3 |
| » Starters: Frank Sullivan vs Bobby Shantz | Fourth | 4 out |
| Friday, July 22 |
| » Lost to White Sox (56-35), 10-7 | Comiskey Park I (1-5) | 53-40 | |
| » Starters: Tom Brewer vs Jack Harshman | Fourth | 4 out |
| Saturday, July 23 |
| » Defeated White Sox (56-36), 9-7 | Comiskey Park I (2-5) | 54-40 | |
| » Starters: Leo Kiely vs Harry Byrd | Fourth | 3 out |
| Sunday, July 24 |
| » Lost to White Sox (57-36), 4-0 | Comiskey Park I (2-6) | 54-41 | |
| » Starters: George Susce vs Billy Pierce | Fourth | 4 out |
| » Defeated White Sox (57-37), 2-1 | Comiskey Park I (3-6) | 55-41 | |
| » Starters: Willard Nixon vs Connie Johnson | Fourth | 4 out |
| Tuesday, July 26 |
| » Defeated Indians (58-39), 5-1 | Fenway Park (29-13) | 56-41 | Won 2 |
| » Starters: Herb Score vs Frank Sullivan | Fourth | 4 out |
| Wednesday, July 27 |
| » Defeated Indians (58-40), 6-2 | Fenway Park (30-13) | 57-41 | Won 3 |
| » Starters: Art Houtteman vs Tom Brewer | Fourth | 3 out |
| Thursday, July 28 |
| » Lost to Indians (59-40), 6-4 | Fenway Park (30-14) | 57-42 | |
| » Starters: Early Wynn vs Mel Parnell | Fourth | 3 out |
| Friday, July 29 |
| » Defeated Tigers (54-45), 5-0 | Fenway Park (31-14) | 58-42 | |
| » Starters: Jim Bunning vs Willard Nixon | Fourth | 3 out |
| Saturday, July 30 |
| » Lost to Tigers (55-45), 5-2 | Fenway Park (31-15) | 58-43 | |
| » Starters: Babe Birrer vs George Susce | Third | 3 out |
| Sunday, July 31 |
| » Defeated Tigers (55-46), 8-3 | Fenway Park (32-15) | 59-43 | |
| » Starters: Ned Garver vs Frank Sullivan | Third | 3 out |
| » Defeated Tigers (55-47), 3-2 | Fenway Park (33-15) | 60-43 | Won 2 |
| » Starters: Billy Hoeft vs Ike Delock | Third | 3 out |
| » Major-league debuts: Frank Baumann (Red Sox) |
| Tuesday, August 2 |
| » Lost to White Sox (63-39), 2-1 | Fenway Park (33-16) | 60-44 | |
| » Starters: Connie Johnson vs Tom Brewer | Fourth | 4 out |
| Future Red Sox Jim Dorsey is born in Oak Park, IL. |
| Wednesday, August 3 |
| » Defeated White Sox (63-40), 6-4 | Fenway Park (34-16) | 61-44 | |
| » Starters: Virgil Trucks vs Mel Parnell | Third | 3 out |
| Thursday, August 4 |
| » Defeated White Sox (63-41), 7-3 | Fenway Park (35-16) | 62-44 | Won 2 |
| » Starters: Billy Pierce vs Willard Nixon | Fourth | 2 out |
| Friday, August 5 |
| » Lost to Athletics (45-63), 5-2 | Fenway Park (35-17) | 62-45 | |
| » Starters: Vic Raschi vs Frank Sullivan | Third | 2 out |
| Saturday, August 6 |
| » Lost to Athletics (46-63), 6-5 | Fenway Park (35-18) | 62-46 | Lost 2 |
| » Starters: Arnie Portocarrero vs George Susce | Third | 2 out |
| Future Red Sox Jim Pankovits is born in Pennington Gap, VA. |
| Sunday, August 7 |
| » Defeated Athletics (46-64), 16-12 | Fenway Park (36-18) | 63-46 | |
| » Starters: Art Ditmar vs Tom Brewer | Fourth | 1½ out |
| Tuesday, August 9 |
| » Defeated Yankees (65-46), 4-1 | Yankee Stadium (4-2) | 64-46 | Won 2 |
| » Starters: Willard Nixon vs Whitey Ford | Fourth | 1½ out |
| Wednesday, August 10 |
| » Lost to Yankees (66-46), 3-2 | Yankee Stadium (4-3) | 64-47 | |
| » Starters: Frank Sullivan vs Don Larsen | Fourth | 2 out |
| Thursday, August 11 |
| » Lost to Yankees (67-46), 5-3 | Yankee Stadium (4-4) | 64-48 | Lost 2 |
| » Starters: Frank Baumann vs Bob Turley | Fourth | 3 out |
| Saturday, August 13 |
| » Lost to Senators (41-70), 18-9 | Fenway Park (36-19) | 64-49 | Lost 3 |
| » Starters: Bob Porterfield vs Willard Nixon | Fourth | 5 out |
| » Major-league debuts: Jim Pagliaroni (Red Sox) |
| Sunday, August 14 |
| » Defeated Senators (41-71), 9-6 | Fenway Park (37-19) | 65-49 | |
| » Starters: Spec Shea vs Tom Brewer | Fourth | 3½ out |
| » Defeated Senators (41-72), 2-1 | Fenway Park (38-19) | 66-49 | Won 2 |
| » Starters: Pedro Ramos vs George Susce | Fourth | 3½ out |
| Monday, August 15 |
| » Defeated Senators (41-73), 8-4 | Fenway Park (39-19) | 67-49 | Won 3 |
| » Starters: Ted Abernathy vs Mel Parnell | Fourth | 3½ out |
| Tuesday, August 16 |
| » Lost to Yankees (72-46), 13-6 | Fenway Park (39-20) | 67-50 | |
| » Starters: Don Larsen vs Frank Sullivan | Fourth | 4½ out |
| Wednesday, August 17 |
| » Defeated Yankees (72-47), 7-1 | Fenway Park (40-20) | 68-50 | |
| » Starters: Bob Turley vs Ike Delock | Fourth | 3½ out |
| Friday, August 19 |
| » Defeated Senators (41-75), 8-0 | Griffith Stadium (5-4) | 69-50 | Won 2 |
| » Starters: Frank Sullivan vs Bob Porterfield | Fourth | 3½ out |
| Saturday, August 20 |
| » Lost to Senators (42-75), 6-2 | Griffith Stadium (5-5) | 69-51 | |
| » Starters: Willard Nixon vs Pedro Ramos | Fourth | 4½ out |
| Sunday, August 21 |
| » Defeated Senators (42-76), 4-1 | Griffith Stadium (6-5) | 70-51 | |
| » Starters: George Susce vs Chuck Stobbs | Fourth | 4½ out |
| Tuesday, August 23 |
| » Defeated Indians (74-49), 8-3 | Cleveland Stadium (5-5) | 71-51 | Won 2 |
| » Starters: Tom Brewer vs Herb Score | Fourth | 3½ out |
| Wednesday, August 24 |
| » Lost to Indians (75-49), 2-0 | Cleveland Stadium (5-6) | 71-52 | |
| » Starters: Frank Sullivan vs Mike Garcia | Fourth | 4½ out |
| Thursday, August 25 |
| » Lost to Tigers (64-61), 6-1 | Tiger Stadium (3-5) | 71-53 | Lost 2 |
| » Starters: Willard Nixon vs Ned Garver | Fourth | 5 out |
| » Defeated Tigers (64-62), 6-4 | Tiger Stadium (4-5) | 72-53 | |
| » Starters: Ike Delock vs Babe Birrer | Fourth | 5 out |
| Friday, August 26 |
| » Lost to Tigers (65-62), 5-4 | Tiger Stadium (4-6) | 72-54 | |
| » Starters: George Susce vs Billy Hoeft | Fourth | 5 out |
| Saturday, August 27 |
| » Defeated Tigers (65-63), 4-3 | Tiger Stadium (5-6) | 73-54 | |
| » Starters: Frank Baumann vs Frank Lary | Third | 4 out |
| Sunday, August 28 |
| » Defeated Athletics (53-75), 14-2 | Municipal Stadium (6-4) | 74-54 | Won 2 |
| » Starters: Frank Sullivan vs Vic Raschi | Fourth | 3½ out |
| Tuesday, August 30 |
| » Lost to White Sox (78-51), 7-5 | Comiskey Park I (3-7) | 74-55 | |
| » Starters: Willard Nixon vs Virgil Trucks | Third | 4 out |
| Wednesday, August 31 |
| » Lost to White Sox (79-51), 4-2 | Comiskey Park I (3-8) | 74-56 | Lost 2 |
| » Starters: Tom Brewer vs Bob Keegan | Third | 5 out |
| Friday, September 2 |
| » Defeated Orioles (41-87), 8-3 | Memorial Stadium (6-3) | 75-56 | |
| » Starters: Frank Sullivan vs Ray Moore | Fourth | 5 out |
| Saturday, September 3 |
| » Defeated Orioles (41-88), 2-1 | Memorial Stadium (7-3) | 76-56 | Won 2 |
| » Starters: Ike Delock vs Ed Lopat | Third | 4 out |
| Sunday, September 4 |
| » Defeated Orioles (41-89), 5-4 | Memorial Stadium (8-3) | 77-56 | Won 3 |
| » Starters: Frank Baumann vs Erv Palica | Fourth | 4 out |
| Monday, September 5 |
| » Defeated Senators (47-84), 10-2 | Fenway Park (41-20) | 78-56 | Won 4 |
| » Starters: Ted Abernathy vs Tom Brewer | Fourth | 3 out |
| » Defeated Senators (47-85), 7-2 | Fenway Park (42-20) | 79-56 | Won 5 |
| » Starters: Mickey McDermott vs George Susce | Fourth | 3 out |
| Wednesday, September 7 |
| » Defeated Tigers (70-68), 7-4 | Fenway Park (43-20) | 80-56 | Won 6 |
| » Starters: Jim Bunning vs Frank Sullivan | Fourth | 3 out |
| Thursday, September 8 |
| » Lost to Tigers (71-68), 5-4 | Fenway Park (43-21) | 80-57 | |
| » Starters: Al Aber vs Willard Nixon | Fourth | 4 out |
| Friday, September 9 |
| » Lost to Indians (86-54), 3-1 | Fenway Park (43-22) | 80-58 | Lost 2 |
| » Starters: Bob Lemon vs Ike Delock | Fourth | 5 out |
| Saturday, September 10 |
| » Lost to Indians (87-54), 10-7 | Fenway Park (43-23) | 80-59 | Lost 3 |
| » Starters: Mike Garcia vs Tom Brewer | Fourth | 6 out |
| » Major-league debuts: Hank Aguirre, Rocky Colavito and Buddy Daley (Indians) |
| Former Red Sox Shano Collins dies in Newton, MA at the age of 70. |
| Sunday, September 11 |
| » Defeated White Sox (83-58), 6-2 | Fenway Park (44-23) | 81-59 | |
| » Starters: Bob Keegan vs Frank Sullivan | Fourth | 6 out |
| » Lost to White Sox (84-58), 7-2 | Fenway Park (44-24) | 81-60 | |
| » Starters: Connie Johnson vs George Susce | Fourth | 6 out |
| Tuesday, September 13 |
| » Lost to Athletics (60-83), 6-5 | Fenway Park (44-25) | 81-61 | Lost 2 |
| » Starters: Vic Raschi vs Willard Nixon | Fourth | 7 out |
| » Defeated Athletics (60-84), 7-6 | Fenway Park (45-25) | 82-61 | |
| » Starters: Arnie Portocarrero vs Frank Baumann | Fourth | 7 out |
| Wednesday, September 14 |
| » Lost to Athletics (61-84), 7-3 | Fenway Park (45-26) | 82-62 | |
| » Starters: Art Ditmar vs Ike Delock | Fourth | 7 out |
| Friday, September 16 |
| » Lost to Yankees (89-56), 5-4 | Yankee Stadium (4-5) | 82-63 | Lost 2 |
| » Starters: Frank Sullivan vs Whitey Ford | Fourth | 7 out |
| Saturday, September 17 |
| » Lost to Yankees (90-56), 4-1 | Yankee Stadium (4-6) | 82-64 | Lost 3 |
| » Starters: Bill Henry vs Tommy Byrne | Fourth | 8 out |
| » Major-league debuts: Frank Malzone (Red Sox) |
| Sunday, September 18 |
| » Lost to Yankees (91-56), 3-2 | Yankee Stadium (4-7) | 82-65 | Lost 4 |
| » Starters: Willard Nixon vs Bob Turley | Fourth | 9 out |
| Tuesday, September 20 |
| » Lost to Orioles (52-95), 3-2 | Fenway Park (45-27) | 82-66 | Lost 5 |
| » Starters: Bill Wight vs Frank Sullivan | Fourth | 11 out |
| » Lost to Orioles (53-95), 7-4 | Fenway Park (45-28) | 82-67 | Lost 6 |
| » Starters: Ray Moore vs Ike Delock | Fourth | 11 out |
| » Major-league debuts: Haywood Sullivan (Red Sox) |
| Wednesday, September 21 |
| » Lost to Orioles (54-95), 8-7 | Fenway Park (45-29) | 82-68 | Lost 7 |
| » Starters: Erv Palica vs Frank Baumann | Fourth | 12 out |
| Friday, September 23 |
| » Defeated Yankees (94-57), 8-4 | Fenway Park (46-29) | 83-68 | |
| » Starters: Tommy Byrne vs Tom Brewer | Fourth | 12 out |
| » Lost to Yankees (95-57), 3-2 | Fenway Park (46-30) | 83-69 | |
| » Starters: Don Larsen vs Willard Nixon | Fourth | 12 out |
| Sunday, September 25 |
| » Lost to Yankees (96-57), 9-2 | Fenway Park (46-31) | 83-70 | Lost 2 |
| » Starters: |