| Saturday, January 1 |
| Future Indian Bob Owchinko is born in Detroit, MI. |
| Monday, January 24 |
| Future Indian Ted Cox is born in Oklahoma City, OK. |
| Monday, January 31 |
| Future Indian Ted Power is born in Guthrie, OK. |
| Tuesday, February 1 |
| Future Indian Ernie Camacho is born in Salinas, CA. |
| Monday, April 11 |
| » Major-league debuts: Ernie Oravetz and Pedro Ramos (Senators) Don Ferrarese and Don Leppert (Orioles) |
| Tuesday, April 12 |
| » Defeated White Sox (0-1), 5-1 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Virgil Trucks vs Bob Lemon | First | -- |
| Wednesday, April 13 |
| » Major-league debuts: Ted Abernathy (Senators) |
| Thursday, April 14 |
| » Defeated Tigers (1-2), 5-3 | Tiger Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Mike Garcia vs Billy Hoeft | First | -- |
| » Major-league debuts: Joe Altobelli (Indians) |
| Friday, April 15 |
| » Defeated Tigers (1-3), 7-3 | Tiger Stadium (2-0) | 3-0 | Won 3 |
| » Starters: Herb Score vs Frank Lary | First | -- |
| » Major-league debuts: Herb Score (Indians) |
| Saturday, April 16 |
| » Lost to White Sox (2-1), 9-4 | Comiskey Park I (0-1) | 3-1 | |
| » Starters: Bob Feller vs Billy Pierce | First | -- |
| Sunday, April 17 |
| » Lost to White Sox (3-1), 3-1 | Comiskey Park I (0-2) | 3-2 | Lost 2 |
| » Starters: Art Houtteman vs Jack Harshman | Second | 1 out |
| » Defeated White Sox (3-2), 4-2 | Comiskey Park I (1-2) | 4-2 | |
| » Starters: Bob Lemon vs Virgil Trucks | Second | 1 out |
| Monday, April 18 |
| » Defeated Athletics (1-5), 11-9 | Municipal Stadium (1-0) | 5-2 | Won 2 |
| » Starters: Mike Garcia vs Alex Kellner | Second | ½ out |
| Tuesday, April 19 |
| » Lost to Athletics (2-5), 8-7 | Municipal Stadium (1-1) | 5-3 | |
| » Starters: Herb Score vs Cloyd Boyer | Third | 1 out |
| Friday, April 22 |
| » Defeated Tigers (3-5), 8-5 | Cleveland Stadium (2-0) | 6-3 | |
| » Starters: Steve Gromek vs Bob Lemon | Second | 1 out |
| Future Indian David Clyde is born in Kansas City, KS. |
| Saturday, April 23 |
| » Lost to Tigers (4-5), 3-0 | Cleveland Stadium (2-1) | 6-4 | |
| » Starters: Billy Hoeft vs Mike Garcia | Third | 1 out |
| Sunday, April 24 |
| » Lost to Tigers (5-5), 6-4 | Cleveland Stadium (2-2) | 6-5 | Lost 2 |
| » Starters: Frank Lary vs Herb Score | Third | 1 out |
| Tuesday, April 26 |
| » Defeated Senators (5-6), 3-2 | Cleveland Stadium (3-2) | 7-5 | |
| » Starters: Mickey McDermott vs Bob Lemon | Third | 1 out |
| Wednesday, April 27 |
| » Defeated Senators (5-7), 6-5 | Cleveland Stadium (4-2) | 8-5 | Won 2 |
| » Starters: Bob Porterfield vs Early Wynn | Second | 1 out |
| Friday, April 29 |
| » Lost to Orioles (4-11), 5-2 | Cleveland Stadium (4-3) | 8-6 | |
| » Starters: Harry Byrd vs Mike Garcia | Fourth | 1 out |
| Saturday, April 30 |
| » Defeated Orioles (4-12), 5-2 | Cleveland Stadium (5-3) | 9-6 | |
| » Starters: Saul Rogovin vs Bob Lemon | Third | 1 out |
| Sunday, May 1 |
| » Defeated Red Sox (8-9), 2-0 | Cleveland Stadium (6-3) | 10-6 | Won 2 |
| » Starters: Frank Sullivan vs Bob Feller | First | -- |
| » Defeated Red Sox (8-10), 2-1 | Cleveland Stadium (7-3) | 11-6 | Won 3 |
| » Starters: Tom Brewer vs Herb Score | First | -- |
| Monday, May 2 |
| » Defeated Red Sox (8-11), 4-2 | Cleveland Stadium (8-3) | 12-6 | Won 4 |
| » Starters: Russ Kemmerer vs Early Wynn | First | -- |
| Tuesday, May 3 |
| » Defeated Yankees (10-8), 7-4 | Cleveland Stadium (9-3) | 13-6 | Won 5 |
| » Starters: Ed Lopat vs Mike Garcia | First | -- |
| Wednesday, May 4 |
| » Lost to Yankees (11-8), 11-5 | Cleveland Stadium (9-4) | 13-7 | |
| » Starters: Whitey Ford vs Bob Lemon | First | -- |
| Friday, May 6 |
| » Defeated Athletics (9-10), 4-1 | Cleveland Stadium (10-4) | 14-7 | |
| » Starters: Alex Kellner vs Herb Score | First | -- |
| Saturday, May 7 |
| » Defeated Athletics (9-11), 9-3 | Cleveland Stadium (11-4) | 15-7 | Won 2 |
| » Starters: Bobby Shantz vs Early Wynn | First | -- |
| Sunday, May 8 |
| » Defeated Athletics (9-12), 9-6 | Cleveland Stadium (12-4) | 16-7 | Won 3 |
| » Starters: Cloyd Boyer vs Bob Feller | First | -- |
| » Defeated Athletics (9-13), 2-1 | Cleveland Stadium (13-4) | 17-7 | Won 4 |
| » Starters: Art Ceccarelli vs Mike Garcia | First | -- |
| Tuesday, May 10 |
| » Defeated Yankees (14-9), 9-6 | Yankee Stadium (1-0) | 18-7 | Won 5 |
| » Starters: Bob Lemon vs Don Larsen | First | -- |
| Wednesday, May 11 |
| » Defeated Yankees (14-10), 4-3 | Yankee Stadium (2-0) | 19-7 | Won 6 |
| » Starters: Early Wynn vs Bob Turley | First | -- |
| Thursday, May 12 |
| » Lost to Senators (11-15), 3-0 | Griffith Stadium (0-1) | 19-8 | |
| » Starters: Herb Score vs Mickey McDermott | First | -- |
| Friday, May 13 |
| Former Indian Lefty George dies in York, PA at the age of 69. |
| Saturday, May 14 |
| Future Indian Dennis Martinez is born in Granada, Nicaragua. |
| Sunday, May 15 |
| » Lost to Orioles (9-19), 4-1 | Memorial Stadium (0-1) | 19-9 | Lost 2 |
| » Starters: Bob Lemon vs Jim Wilson | First | -- |
| » Defeated Orioles (9-20), 5-0 | Memorial Stadium (1-1) | 20-9 | |
| » Starters: Mike Garcia vs Bob Kuzava | First | -- |
| Monday, May 16 |
| Future Indian Jack Morris is born in St. Paul, MN. |
| Tuesday, May 17 |
| » Lost to Red Sox (15-18), 10-3 | Fenway Park (0-1) | 20-10 | |
| » Starters: Early Wynn vs Bill Henry | First | -- |
| Wednesday, May 18 |
| » Defeated Red Sox (15-19), 19-0 | Fenway Park (1-1) | 21-10 | |
| » Starters: Herb Score vs Willard Nixon | First | -- |
| Thursday, May 19 |
| Future Indian Ed Whitson is born in Johnson City, TN. |
| Friday, May 20 |
| » Lost to Tigers (18-15), 11-4 | Tiger Stadium (2-1) | 21-11 | |
| » Starters: Bob Lemon vs Billy Hoeft | First | -- |
| Saturday, May 21 |
| » Lost to Tigers (19-15), 3-2 | Tiger Stadium (2-2) | 21-12 | Lost 2 |
| » Starters: Mike Garcia vs Duke Maas | Second | ½ out |
| Sunday, May 22 |
| » Defeated Tigers (19-16), 4-0 | Tiger Stadium (3-2) | 22-12 | |
| » Starters: Early Wynn vs Ned Garver | Second | 1 out |
| Tuesday, May 24 |
| » Lost to White Sox (21-13), 4-1 | Cleveland Stadium (13-5) | 22-13 | |
| » Starters: Billy Pierce vs Herb Score | Second | 1 out |
| Wednesday, May 25 |
| Future Indian Andres Mora is born in Rio Bravo, Mexico. |
| Thursday, May 26 |
| » Lost to White Sox (22-13), 3-1 | Cleveland Stadium (13-6) | 22-14 | Lost 2 |
| » Starters: Jack Harshman vs Bob Lemon | Second | 2½ out |
| » Defeated White Sox (22-14), 10-9 | Cleveland Stadium (14-6) | 23-14 | |
| » Starters: Sandy Consuegra vs Mike Garcia | Second | 2½ out |
| Saturday, May 28 |
| » Defeated Athletics (14-24), 7-2 | Municipal Stadium (2-1) | 24-14 | Won 2 |
| » Starters: Early Wynn vs Alex Kellner | Second | 3 out |
| Sunday, May 29 |
| » Defeated Athletics (14-25), 4-2 | Municipal Stadium (3-1) | 25-14 | Won 3 |
| » Starters: Herb Score vs Bobby Shantz | Second | 3 out |
| Monday, May 30 |
| » Defeated White Sox (24-16), 9-1 | Comiskey Park I (2-2) | 26-14 | Won 4 |
| » Starters: Bob Lemon vs Jack Harshman | Second | 3 out |
| » Lost to White Sox (25-16), 5-0 | Comiskey Park I (2-3) | 26-15 | |
| » Starters: Mike Garcia vs Billy Pierce | Second | 3 out |
| Tuesday, May 31 |
| » Defeated Orioles (14-31), 2-1 | Cleveland Stadium (15-6) | 27-15 | |
| » Starters: Jim Wilson vs Bob Feller | Second | 2½ out |
| Wednesday, June 1 |
| » Defeated Orioles (14-32), 5-0 | Cleveland Stadium (16-6) | 28-15 | Won 2 |
| » Starters: Erv Palica vs Early Wynn | Second | 3 out |
| Thursday, June 2 |
| » Defeated Orioles (14-33), 9-3 | Cleveland Stadium (17-6) | 29-15 | Won 3 |
| » Starters: Saul Rogovin vs Herb Score | Second | 3 out |
| Friday, June 3 |
| » Lost to Senators (18-26), 3-1 | Cleveland Stadium (17-7) | 29-16 | |
| » Starters: Mickey McDermott vs Bob Lemon | Second | 3 out |
| Saturday, June 4 |
| » Lost to Senators (19-26), 14-5 | Cleveland Stadium (17-8) | 29-17 | Lost 2 |
| » Starters: Bob Porterfield vs Mike Garcia | Second | 4 out |
| Sunday, June 5 |
| » Lost to Senators (20-26), 6-4 | Cleveland Stadium (17-9) | 29-18 | Lost 3 |
| » Starters: Johnny Schmitz vs Bob Feller | Second | 4 out |
| » Defeated Senators (20-27), 6-3 | Cleveland Stadium (18-9) | 30-18 | |
| » Starters: Dean Stone vs Early Wynn | Second | 4 out |
| Tuesday, June 7 |
| » Lost to Red Sox (22-30), 9-5 | Cleveland Stadium (18-10) | 30-19 | |
| » Starters: Mel Parnell vs Herb Score | Third | 4½ out |
| Wednesday, June 8 |
| » Lost to Red Sox (23-30), 5-4 | Cleveland Stadium (18-11) | 30-20 | Lost 2 |
| » Starters: Bill Henry vs Bob Lemon | Third | 4½ out |
| Thursday, June 9 |
| » Lost to Red Sox (24-30), 4-2 | Cleveland Stadium (18-12) | 30-21 | Lost 3 |
| » Starters: Frank Sullivan vs Herb Score | Third | 5½ out |
| Friday, June 10 |
| » Lost to Yankees (38-17), 3-2 | Cleveland Stadium (18-13) | 30-22 | Lost 4 |
| » Starters: Tommy Byrne vs Mike Garcia | Third | 6½ out |
| Saturday, June 11 |
| » Defeated Yankees (38-18), 7-6 | Cleveland Stadium (19-13) | 31-22 | |
| » Starters: Ed Lopat vs Don Mossi | Third | 5½ out |
| Sunday, June 12 |
| » Defeated Yankees (38-19), 10-2 | Cleveland Stadium (20-13) | 32-22 | Won 2 |
| » Starters: Bob Turley vs Early Wynn | Third | 3½ out |
| » Defeated Yankees (38-20), 7-3 | Cleveland Stadium (21-13) | 33-22 | Won 3 |
| » Starters: Bob Grim vs Bob Lemon | Third | 3½ out |
| Tuesday, June 14 |
| » Defeated Senators (22-33), 6-4 | Griffith Stadium (1-1) | 34-22 | Won 4 |
| » Starters: Mike Garcia vs Camilo Pascual | Third | 3 out |
| » Defeated Senators (22-34), 3-1 | Griffith Stadium (2-1) | 35-22 | Won 5 |
| » Starters: Herb Score vs Mickey McDermott | Third | 3 out |
| Wednesday, June 15 |
| » Lost to Senators (23-34), 7-0 | Griffith Stadium (2-2) | 35-23 | |
| » Starters: Bob Feller vs Dean Stone | Third | 3 out |
| Thursday, June 16 |
| » Defeated Senators (23-35), 8-5 | Griffith Stadium (3-2) | 36-23 | |
| » Starters: Bob Lemon vs Chuck Stobbs | Third | 3 out |
| Friday, June 17 |
| » Lost to Red Sox (29-31), 6-5 | Fenway Park (1-2) | 36-24 | |
| » Starters: Early Wynn vs Tom Brewer | Third | 2½ out |
| » Defeated Red Sox (29-32), 3-2 | Fenway Park (2-2) | 37-24 | |
| » Starters: Ray Narleski vs George Susce | Third | 2½ out |
| Future Indian Joe Charboneau is born in Belvidere, IL. |
| Saturday, June 18 |
| » Lost to Red Sox (30-32), 4-2 | Fenway Park (2-3) | 37-25 | |
| » Starters: Mike Garcia vs Frank Sullivan | Third | 2½ out |
| Sunday, June 19 |
| » Lost to Red Sox (31-32), 11-7 | Fenway Park (2-4) | 37-26 | Lost 2 |
| » Starters: Herb Score vs Mel Parnell | Third | 4 out |
| Tuesday, June 21 |
| » Defeated Orioles (20-43), 3-1 | Memorial Stadium (2-1) | 38-26 | |
| » Starters: Bob Lemon vs Jim Wilson | Third | 4 out |
| » Major-league debuts: Tommy Gastall (Orioles) |
| Wednesday, June 22 |
| » Defeated Orioles (20-44), 5-0 | Memorial Stadium (3-1) | 39-26 | Won 2 |
| » Starters: Early Wynn vs Art Schallock | Third | 4 out |
| Former Indian Frankie Hayes dies in Point Pleasant, NJ at the age of 41. |
| Thursday, June 23 |
| » Defeated Orioles (20-45), 9-2 | Memorial Stadium (4-1) | 40-26 | Won 3 |
| » Starters: Bob Feller vs Duane Pillette | Third | 4 out |
| Friday, June 24 |
| » Lost to Yankees (46-23), 2-1 | Yankee Stadium (2-1) | 40-27 | |
| » Starters: Mike Garcia vs Johnny Kucks | Third | 5 out |
| Saturday, June 25 |
| » Lost to Yankees (47-23), 3-2 | Yankee Stadium (2-2) | 40-28 | Lost 2 |
| » Starters: Art Houtteman vs Ed Lopat | Third | 6 out |
| Sunday, June 26 |
| » Defeated Yankees (47-24), 5-0 | Yankee Stadium (3-2) | 41-28 | |
| » Starters: Early Wynn vs Tommy Byrne | Third | 6 out |
| » Lost to Yankees (48-24), 2-0 | Yankee Stadium (3-3) | 41-29 | |
| » Starters: Bob Lemon vs Whitey Ford | Third | 6 out |
| Tuesday, June 28 |
| » Defeated Athletics (27-41), 7-5 | Cleveland Stadium (22-13) | 42-29 | |
| » Starters: Art Ditmar vs Mike Garcia | Third | 5½ out |
| Wednesday, June 29 |
| » Lost to Athletics (28-41), 12-4 | Cleveland Stadium (22-14) | 42-30 | |
| » Starters: Bobby Shantz vs Bob Feller | Third | 7 out |
| Friday, July 1 |
| » Defeated White Sox (42-28), 1-0 | Cleveland Stadium (23-14) | 43-30 | |
| » Starters: Billy Pierce vs Early Wynn | Third | 7 out |
| Saturday, July 2 |
| » Lost to White Sox (43-28), 2-1 | Cleveland Stadium (23-15) | 43-31 | |
| » Starters: Jack Harshman vs Herb Score | Third | 8 out |
| Sunday, July 3 |
| » Defeated White Sox (43-29), 14-9 | Cleveland Stadium (24-15) | 44-31 | |
| » Starters: Dick Donovan vs Bob Lemon | Third | 7 out |
| Monday, July 4 |
| » Defeated Tigers (38-36), 6-5 | Cleveland Stadium (25-15) | 45-31 | Won 2 |
| » Starters: Billy Hoeft vs Art Houtteman | Second | 5 out |
| » Defeated Tigers (38-37), 8-5 | Cleveland Stadium (26-15) | 46-31 | Won 3 |
| » Starters: Steve Gromek vs Mike Garcia | Second | 5 out |
| Tuesday, July 5 |
| » Lost to Athletics (34-42), 4-3 | Municipal Stadium (3-2) | 46-32 | |
| » Starters: Early Wynn vs Bobby Shantz | Third | 5½ out |
| Wednesday, July 6 |
| » Defeated Athletics (34-43), 8-4 | Municipal Stadium (4-2) | 47-32 | |
| » Starters: Herb Score vs Alex Kellner | Second | 4½ out |
| Thursday, July 7 |
| » Defeated Athletics (34-44), 9-1 | Municipal Stadium (5-2) | 48-32 | Won 2 |
| » Starters: Mike Garcia vs Art Ceccarelli | Second | 4 out |
| Future Indian Len Barker is born in Fort Knox, KY. Future Indian Jerry Dybzinski is born in Cleveland, OH. |
| Friday, July 8 |
| » Defeated White Sox (45-32), 1-0 | Comiskey Park I (3-3) | 49-32 | Won 3 |
| » Starters: Bob Lemon vs Billy Pierce | Second | 4 out |
| Saturday, July 9 |
| » Lost to White Sox (46-32), 6-0 | Comiskey Park I (3-4) | 49-33 | |
| » Starters: Early Wynn vs Connie Johnson | Second | 5 out |
| Sunday, July 10 |
| » Defeated White Sox (46-33), 5-2 | Comiskey Park I (4-4) | 50-33 | |
| » Starters: Art Houtteman vs Jack Harshman | Second | 5 out |
| » Lost to White Sox (47-33), 4-2 | Comiskey Park I (4-5) | 50-34 | |
| » Starters: Herb Score vs Virgil Trucks | Second | 5 out |
| Tuesday, July 12 |
| Former Indian Jesse Stovall dies in San Diego, CA at the age of 80. |
| Thursday, July 14 |
| » Defeated Yankees (55-30), 5-4 | Cleveland Stadium (27-15) | 51-34 | |
| » Starters: Tommy Byrne vs Bob Lemon | Second | 4 out |
| Friday, July 15 |
| » Lost to Yankees (56-30), 4-3 | Cleveland Stadium (27-16) | 51-35 | |
| » Starters: Bob Turley vs Early Wynn | Third | 5 out |
| Saturday, July 16 |
| » Defeated Red Sox (49-38), 4-1 | Cleveland Stadium (28-16) | 52-35 | |
| » Starters: Frank Sullivan vs Art Houtteman | Third | 3½ out |
| Sunday, July 17 |
| » Lost to Red Sox (50-38), 6-0 | Cleveland Stadium (28-17) | 52-36 | |
| » Starters: Tom Brewer vs Herb Score | Third | 3 out |
| » Defeated Red Sox (50-39), 6-5 | Cleveland Stadium (29-17) | 53-36 | |
| » Starters: Bill Henry vs Mike Garcia | Third | 3 out |
| Tuesday, July 19 |
| » Lost to Senators (31-57), 8-1 | Cleveland Stadium (29-18) | 53-37 | |
| » Starters: Dean Stone vs Bob Lemon | Third | 4 out |
| Wednesday, July 20 |
| » Lost to Senators (32-57), 6-4 | Cleveland Stadium (29-19) | 53-38 | Lost 2 |
| » Starters: Chuck Stobbs vs Early Wynn | Third | 4 out |
| Thursday, July 21 |
| » Defeated Senators (32-58), 4-3 | Cleveland Stadium (30-19) | 54-38 | |
| » Starters: Johnny Schmitz vs Art Houtteman | Third | 3 out |
| Friday, July 22 |
| » Defeated Orioles (28-61), 2-0 | Cleveland Stadium (31-19) | 55-38 | Won 2 |
| » Starters: Jim Wilson vs Herb Score | Third | 2 out |
| Saturday, July 23 |
| » Defeated Orioles (28-62), 3-2 | Cleveland Stadium (32-19) | 56-38 | Won 3 |
| » Starters: Bill Wight vs Mike Garcia | Third | 1 out |
| Sunday, July 24 |
| » Defeated Orioles (28-63), 5-1 | Cleveland Stadium (33-19) | 57-38 | Won 4 |
| » Starters: Jim McDonald vs Bob Feller | Third | 1 out |
| » Defeated Orioles (28-64), 5-2 | Cleveland Stadium (34-19) | 58-38 | Won 5 |
| » Starters: Erv Palica vs Early Wynn | Third | 1 out |
| Tuesday, July 26 |
| » Lost to Red Sox (56-41), 5-1 | Fenway Park (2-5) | 58-39 | |
| » Starters: Herb Score vs Frank Sullivan | Third | 2 out |
| Wednesday, July 27 |
| » Lost to Red Sox (57-41), 6-2 | Fenway Park (2-6) | 58-40 | Lost 2 |
| » Starters: Art Houtteman vs Tom Brewer | Third | 2 out |
| Thursday, July 28 |
| » Defeated Red Sox (57-42), 6-4 | Fenway Park (3-6) | 59-40 | |
| » Starters: Early Wynn vs Mel Parnell | Third | 1 out |
| Friday, July 29 |
| » Defeated Orioles (29-69), 7-1 | Memorial Stadium (5-1) | 60-40 | Won 2 |
| » Starters: Mike Garcia vs Bill Wight | Third | 1 out |
| Saturday, July 30 |
| » Defeated Orioles (29-70), 7-0 | Memorial Stadium (6-1) | 61-40 | Won 3 |
| » Starters: Herb Score vs Erv Palica | Second | 1 out |
| Sunday, July 31 |
| » Lost to Orioles (30-70), 4-3 | Memorial Stadium (6-2) | 61-41 | |
| » Starters: Bob Feller vs Ray Moore | Second | 1 out |
| » Defeated Orioles (30-71), 6-0 | Memorial Stadium (7-2) | 62-41 | |
| » Starters: Art Houtteman vs Jim Wilson | Second | 1 out |
| Tuesday, August 2 |
| » Lost to Yankees (63-41), 2-1 | Yankee Stadium (3-4) | 62-42 | |
| » Starters: Early Wynn vs Tommy Byrne | Third | 2 out |
| Wednesday, August 3 |
| » Defeated Yankees (63-42), 2-1 | Yankee Stadium (4-4) | 63-42 | |
| » Starters: Mike Garcia vs Bob Turley | Second | 1 out |
| Thursday, August 4 |
| » Defeated Yankees (63-43), 6-3 | Yankee Stadium (5-4) | 64-42 | Won 2 |
| » Starters: Herb Score vs Whitey Ford | Second | 1 out |
| Friday, August 5 |
| » Lost to Senators (37-69), 7-5 | Griffith Stadium (3-3) | 64-43 | |
| » Starters: Sal Maglie vs Dean Stone | Second | 1 out |
| Saturday, August 6 |
| » Lost to Senators (38-69), 6-5 | Griffith Stadium (3-4) | 64-44 | Lost 2 |
| » Starters: Art Houtteman vs Camilo Pascual | Second | 1 out |
| Sunday, August 7 |
| » Lost to Senators (39-69), 9-3 | Griffith Stadium (3-5) | 64-45 | Lost 3 |
| » Starters: Early Wynn vs Johnny Schmitz | Third | 1½ out |
| Tuesday, August 9 |
| » Defeated Tigers (59-51), 4-2 | Cleveland Stadium (35-19) | 65-45 | |
| » Starters: Ned Garver vs Herb Score | Second | 1½ out |
| Wednesday, August 10 |
| » Defeated Tigers (59-52), 6-4 | Cleveland Stadium (36-19) | 66-45 | Won 2 |
| » Starters: Jim Bunning vs Mike Garcia | First | -- |
| Thursday, August 11 |
| » Defeated Tigers (59-53), 3-1 | Cleveland Stadium (37-19) | 67-45 | Won 3 |
| » Starters: Billy Hoeft vs Early Wynn | First | -- |
| Friday, August 12 |
| » Defeated Athletics (47-67), 17-1 | Municipal Stadium (6-2) | 68-45 | Won 4 |
| » Starters: Bob Lemon vs Arnie Portocarrero | First | -- |
| » Defeated Athletics (47-68), 6-5 | Municipal Stadium (7-2) | 69-45 | Won 5 |
| » Starters: Art Houtteman vs Art Ditmar | First | -- |
| Saturday, August 13 |
| » Defeated Athletics (47-69), 5-3 | Municipal Stadium (8-2) | 70-45 | Won 6 |
| » Starters: Herb Score vs Art Ceccarelli | First | -- |
| Sunday, August 14 |
| » Lost to Athletics (48-69), 7-3 | Municipal Stadium (8-3) | 70-46 | |
| » Starters: Mike Garcia vs Bobby Shantz | First | -- |
| Tuesday, August 16 |
| » Lost to Tigers (61-55), 7-0 | Tiger Stadium (3-3) | 70-47 | Lost 2 |
| » Starters: Early Wynn vs Billy Hoeft | Third | 1½ out |
| Wednesday, August 17 |
| » Lost to Tigers (62-55), 9-5 | Tiger Stadium (3-4) | 70-48 | Lost 3 |
| » Starters: Bob Lemon vs Jim Bunning | Third | 1½ out |
| Thursday, August 18 |
| » Defeated Tigers (62-56), 5-3 | Tiger Stadium (4-4) | 71-48 | |
| » Starters: Herb Score vs Frank Lary | Third | 1 out |
| Friday, August 19 |
| » Defeated Athletics (49-72), 2-1 | Cleveland Stadium (38-19) | 72-48 | Won 2 |
| » Starters: Vic Raschi vs Mike Garcia | Third | 1 out |
| Saturday, August 20 |
| » Defeated Athletics (49-73), 7-5 | Cleveland Stadium (39-19) | 73-48 | Won 3 |
| » Starters: Art Ceccarelli vs Early Wynn | Third | 1 out |
| Sunday, August 21 |
| » Defeated Athletics (49-74), 9-4 | Cleveland Stadium (40-19) | 74-48 | Won 4 |
| » Starters: Art Ditmar vs Bob Lemon | Third | 1 out |
| Tuesday, August 23 |
| » Lost to Red Sox (71-51), 8-3 | Cleveland Stadium (40-20) | 74-49 | |
| » Starters: Tom Brewer vs Herb Score | Third | 1 out |
| Wednesday, August 24 |
| » Defeated Red Sox (71-52), 2-0 | Cleveland Stadium (41-20) | 75-49 | |
| » Starters: Frank Sullivan vs Mike Garcia | Third | 1 out |
| Thursday, August 25 |
| » Lost to Yankees (77-48), 5-2 | Cleveland Stadium (41-21) | 75-50 | |
| » Starters: Rip Coleman vs Early Wynn | Third | 2 out |
| Friday, August 26 |
| » Defeated Yankees (77-49), 5-2 | Cleveland Stadium (42-21) | 76-50 | |
| » Starters: Tommy Byrne vs Bob Lemon | Second | 1 out |
| Saturday, August 27 |
| » Defeated Yankees (77-50), 7-6 | Cleveland Stadium (43-21) | 77-50 | Won 2 |
| » Starters: Don Larsen vs Herb Score | First | -- |
| Sunday, August 28 |
| » Lost to Senators (45-79), 8-2 | Cleveland Stadium (43-22) | 77-51 | |
| » Starters: Dean Stone vs Art Houtteman | Third | 1 out |
| » Lost to Senators (46-79), 13-4 | Cleveland Stadium (43-23) | 77-52 | Lost 2 |
| » Starters: Mickey McDermott vs Mike Garcia | Third | 1 out |
| Tuesday, August 30 |
| » Defeated Orioles (41-85), 7-4 | Cleveland Stadium (44-23) | 78-52 | |
| » Starters: Jim Wilson vs Bob Lemon | Second | ½ out |
| Wednesday, August 31 |
| » Defeated Orioles (41-86), 5-1 | Cleveland Stadium (45-23) | 79-52 | Won 2 |
| » Starters: Bill Wight vs Herb Score | Second | ½ out |
| Friday, September 2 |
| » Lost to White Sox (80-51), 8-1 | Cleveland Stadium (45-24) | 79-53 | |
| » Starters: Jack Harshman vs Sal Maglie | Third | 1½ out |
| Saturday, September 3 |
| » Defeated White Sox (80-52), 6-1 | Cleveland Stadium (46-24) | 80-53 | |
| » Starters: Billy Pierce vs Early Wynn | Second | ½ out |
| Sunday, September 4 |
| » Defeated White Sox (80-53), 5-3 | Cleveland Stadium (47-24) | 81-53 | Won 2 |
| » Starters: Connie Johnson vs Bob Lemon | First | -- |
| » Defeated White Sox (80-54), 5-3 | Cleveland Stadium (48-24) | 82-53 | Won 3 |
| » Starters: Dick Donovan vs Mike Garcia | First | -- |
| Monday, September 5 |
| » Lost to Athletics (56-78), 5-4 | Cleveland Stadium (48-25) | 82-54 | |
| » Starters: Art Ditmar vs Bob Feller | First | -- |
| » Defeated Athletics (56-79), 9-2 | Cleveland Stadium (49-25) | 83-54 | |
| » Starters: Alex Kellner vs Herb Score | First | -- |
| Wednesday, September 7 |
| » Defeated Orioles (42-91), 6-0 | Memorial Stadium (8-2) | 84-54 | Won 2 |
| » Starters: Early Wynn vs Hal Brown | First | -- |
| Thursday, September 8 |
| » Defeated Orioles (42-92), 5-3 | Memorial Stadium (9-2) | 85-54 | Won 3 |
| » Starters: Art Houtteman vs Erv Palica | First | -- |
| Friday, September 9 |
| » Defeated Red Sox (80-58), 3-1 | Fenway Park (4-6) | 86-54 | Won 4 |
| » Starters: Bob Lemon vs Ike Delock | First | -- |
| Saturday, September 10 |
| » Defeated Red Sox (80-59), 10-7 | Fenway Park (5-6) | 87-54 | Won 5 |
| » Starters: Mike Garcia vs Tom Brewer | First | -- |
| » Major-league debuts: Hank Aguirre Rocky Colavito and Buddy Daley (Indians) |
| Sunday, September 11 |
| » Lost to Yankees (86-55), 6-1 | Yankee Stadium (5-5) | 87-55 | |
| » Starters: Early Wynn vs Tommy Byrne | First | -- |
| » Defeated Yankees (86-56), 3-2 | Yankee Stadium (6-5) | 88-55 | |
| » Starters: Herb Score vs Whitey Ford | First | -- |
| Tuesday, September 13 |
| » Defeated Senators (50-90), 3-1 | Griffith Stadium (4-5) | 89-55 | Won 2 |
| » Starters: Mike Garcia vs Chuck Stobbs | First | -- |
| » Defeated Senators (50-91), 8-2 | Griffith Stadium (5-5) | 90-55 | Won 3 |
| » Starters: Bob Lemon vs Bob Porterfield | First | -- |
| » Major-league debuts: Julio Becquer (Senators) |
| Future Indian Mike Fischlin is born in Sacramento, CA. |
| Wednesday, September 14 |
| » Lost to Senators (51-91), 3-2 | Griffith Stadium (5-6) | 90-56 | |
| » Starters: Herb Score vs Mickey McDermott | First | -- |
| Friday, September 16 |
| » Lost to Tigers (73-73), 3-0 | Cleveland Stadium (49-26) | 90-57 | Lost 2 |
| » Starters: Billy Hoeft vs Early Wynn | Second | 1 out |
| Saturday, September 17 |
| » Lost to Tigers (74-73), 3-1 | Cleveland Stadium (49-27) | 90-58 | Lost 3 |
| » Starters: Frank Lary vs Bob Lemon | Second | 1 out |
| Sunday, September 18 |
| » Lost to Tigers (75-73), 10-3 | Cleveland Stadium (49-28) | 90-59 | Lost 4 |
| » Starters: Bob Miller vs Mike Garcia | Second | 2 out |
| Tuesday, September 20 |
| » Defeated White Sox (87-63), 3-2 | Comiskey Park I (5-5) | 91-59 | |
| » Starters: Early Wynn vs Billy Pierce | Second | 2½ out |
| Wednesday, September 21 |
| » Lost to White Sox (88-63), 7-2 | Comiskey Park I (5-6) | 91-60 | |
| » Starters: Bob Lemon vs Jack Harshman | Second | 3½ out |
| Saturday, September 24 |
| » Defeated Tigers (78-74), 8-2 | Tiger Stadium (5-4) | 92-60 | |
| » Starters: Herb Score vs Frank Lary | Second | 2½ out |
| » Defeated Tigers (78-75), 7-0 | Tiger Stadium (6-4) | 93-60 | Won 2 |
| » Starters: Hank Aguirre vs Ned Garver | Second | 2½ out |
| Sunday, September 25 |
| » Lost to Tigers (79-75), 6-2 | Tiger Stadium (6-5) | 93-61 | |
| » Starters: Bud Daley vs Bob Miller | Second | 3 out |
| Tuesday, October 4 |
| Future Indian Lary Sorensen is born in Detroit, MI. |
| Saturday, October 8 |
| Future Indian Jerry Reed is born in Bryson City, NC. |
<