| Saturday, January 22 |
| Former Cardinal Bob Wicker dies in Evanston, IL at the age of 77. |
| Monday, January 31 |
| Future Cardinal Ted Power is born in Guthrie, OK. |
| Tuesday, February 1 |
| Future Cardinal Ernie Camacho is born in Salinas, CA. |
| Saturday, February 5 |
| Future Cardinal Mike Heath is born in Tampa, FL. |
| Wednesday, February 9 |
| Future Cardinal John Urrea is born in Los Angeles, CA. |
| Saturday, February 12 |
| Future Cardinal Steve Mura is born in New Orleans, LA. |
| Sunday, March 27 |
| Former Cardinal Frank Roth dies in Burlington, WI at the age of 77. |
| Monday, April 11 |
| » Major-league debuts: Ernie Oravetz and Pedro Ramos (Senators) Don Ferrarese and Don Leppert (Orioles) |
| Tuesday, April 12 |
| » Lost to Cubs (2-0), 14-4 | Wrigley Field (0-1) | 0-1 | |
| » Starters: Brooks Lawrence vs Paul Minner | Fourth | 1½ out |
| » Major-league debuts: Ken Boyer and Herb Moford Barney Schultz and Bill Virdon (Cardinals) |
| Wednesday, April 13 |
| » Major-league debuts: Ted Abernathy (Senators) |
| Thursday, April 14 |
| » Defeated Braves (1-1), 8-7 | Sportsman's Park III (1-0) | 1-1 | |
| » Starters: Gene Conley vs Harvey Haddix | Third | 1½ out |
| Saturday, April 16 |
| » Defeated Cubs (3-1), 12-11 | Sportsman's Park III (2-0) | 2-1 | Won 2 |
| » Starters: Sam Jones vs Tom Poholsky | Third | 1½ out |
| » Major-league debuts: Bob Speake (Cubs) |
| Sunday, April 17 |
| » Lost to Cubs (4-1), 6-5 | Sportsman's Park III (2-1) | 2-2 | |
| » Starters: Paul Minner vs Gordon Jones | Fourth | 2½ out |
| » Defeated Cubs (4-2), 14-1 | Sportsman's Park III (3-1) | 3-2 | |
| » Starters: Harry Perkowski vs Larry Jackson | Fourth | 2½ out |
| » Major-league debuts: Larry Jackson (Cardinals) Jim King and Bob Thorpe (Cubs) |
| Monday, April 18 |
| » Lost to Reds (2-5), 7-4 | Sportsman's Park III (3-2) | 3-3 | |
| » Starters: Joe Nuxhall vs Vic Raschi | Fourth | 3½ out |
| Tuesday, April 19 |
| » Defeated Reds (2-6), 6-5 | Sportsman's Park III (4-2) | 4-3 | |
| » Starters: Corky Valentine vs Harvey Haddix | Third | 3½ out |
| Wednesday, April 20 |
| » Defeated Reds (2-7), 3-0 | Crosley Field (1-0) | 5-3 | Won 2 |
| » Starters: Luis Arroyo vs Art Fowler | Third | 3½ out |
| » Major-league debuts: Luis Arroyo (Cardinals) |
| Friday, April 22 |
| » Defeated Braves (6-3), 2-1 | County Stadium (1-0) | 6-3 | Won 3 |
| » Starters: Brooks Lawrence vs Warren Spahn | Second | 3 out |
| Saturday, April 23 |
| » Lost to Braves (7-3), 5-4 | County Stadium (1-1) | 6-4 | |
| » Starters: Larry Jackson vs Chet Nichols | Third | 4 out |
| Thursday, April 28 |
| » Lost to Giants (6-7), 6-4 | Polo Grounds V (0-1) | 6-5 | Lost 2 |
| » Starters: Harvey Haddix vs Jim Hearn | Fourth | 5 out |
| Saturday, April 30 |
| » Defeated Giants (6-8), 6-2 | Polo Grounds V (1-1) | 7-5 | |
| » Starters: Brooks Lawrence vs Don Liddle | Third | 5 out |
| Sunday, May 1 |
| » Defeated Pirates (3-12), 4-3 | Forbes Field (1-0) | 8-5 | Won 2 |
| » Starters: Floyd Wooldridge vs Roger Bowman | Second | 5½ out |
| » Lost to Pirates (4-12), 7-0 | Forbes Field (1-1) | 8-6 | |
| » Starters: Gordon Jones vs Ron Kline | Second | 5½ out |
| Monday, May 2 |
| » Lost to Pirates (5-12), 5-1 | Forbes Field (1-2) | 8-7 | Lost 2 |
| » Starters: Harvey Haddix vs Bob Purkey | Third | 6½ out |
| Wednesday, May 4 |
| » Lost to Dodgers (17-2), 12-4 | Ebbets Field (0-1) | 8-8 | Lost 3 |
| » Starters: Brooks Lawrence vs Johnny Podres | Third | 7½ out |
| Thursday, May 5 |
| » Lost to Dodgers (18-2), 4-3 | Ebbets Field (0-2) | 8-9 | Lost 4 |
| » Starters: Larry Jackson vs Tom Lasorda | Fourth | 8½ out |
| Friday, May 6 |
| » Lost to Braves (10-11), 8-5 | Sportsman's Park III (4-3) | 8-10 | Lost 5 |
| » Starters: Chet Nichols vs Gordon Jones | Fifth | 9½ out |
| Saturday, May 7 |
| » Lost to Braves (11-11), 9-7 | Sportsman's Park III (4-4) | 8-11 | Lost 6 |
| » Starters: Gene Conley vs Tom Poholsky | Fifth | 10½ out |
| Sunday, May 8 |
| » Lost to Braves (12-11), 6-2 | Sportsman's Park III (4-5) | 8-12 | Lost 7 |
| » Starters: Warren Spahn vs Harvey Haddix | Sixth | 11½ out |
| Tuesday, May 10 |
| » Defeated Phillies (9-16), 5-3 | Sportsman's Park III (5-5) | 9-12 | |
| » Starters: Curt Simmons vs Luis Arroyo | Sixth | 11½ out |
| Wednesday, May 11 |
| » Defeated Phillies (9-17), 6-5 | Sportsman's Park III (6-5) | 10-12 | Won 2 |
| » Starters: Robin Roberts vs Larry Jackson | Fifth | 10½ out |
| Friday, May 13 |
| » Lost to Giants (14-11), 4-3 | Sportsman's Park III (6-6) | 10-13 | |
| » Starters: Don Liddle vs Harvey Haddix | Fifth | 11 out |
| Saturday, May 14 |
| » Defeated Pirates (11-17), 6-0 | Sportsman's Park III (7-6) | 11-13 | |
| » Starters: Dick Littlefield vs Brooks Lawrence | Fifth | 11 out |
| Sunday, May 15 |
| » Defeated Pirates (11-18), 5-1 | Sportsman's Park III (8-6) | 12-13 | Won 2 |
| » Starters: Max Surkont vs Gordon Jones | Fifth | 10½ out |
| Monday, May 16 |
| » Defeated Pirates (11-19), 6-0 | Sportsman's Park III (9-6) | 13-13 | Won 3 |
| » Starters: Ron Kline vs Luis Arroyo | Fifth | 10 out |
| Tuesday, May 17 |
| » Defeated Dodgers (25-6), 3-0 | Sportsman's Park III (10-6) | 14-13 | Won 4 |
| » Starters: Carl Erskine vs Larry Jackson | Third | 9 out |
| Wednesday, May 18 |
| » Defeated Dodgers (25-7), 3-2 | Sportsman's Park III (11-6) | 15-13 | Won 5 |
| » Starters: Johnny Podres vs Harvey Haddix | Third | 8 out |
| Thursday, May 19 |
| Future Cardinal Alan Knicely is born in Harrisonburg, VA. |
| Friday, May 20 |
| » Lost to Reds (13-18), 10-7 | Crosley Field (1-1) | 15-14 | |
| » Starters: Brooks Lawrence vs Corky Valentine | Fourth | 8 out |
| Saturday, May 21 |
| » Lost to Reds (14-18), 9-6 | Crosley Field (1-2) | 15-15 | Lost 2 |
| » Starters: Gordon Jones vs Gerry Staley | Fourth | 9 out |
| Sunday, May 22 |
| » Lost to Reds (15-18), 4-3 | Crosley Field (1-3) | 15-16 | Lost 3 |
| » Starters: Harvey Haddix vs Joe Nuxhall | Fourth | 9½ out |
| » Defeated Reds (15-19), 5-2 | Crosley Field (2-3) | 16-16 | |
| » Starters: Luis Arroyo vs Johnny Klippstein | Fourth | 9½ out |
| Wednesday, May 25 |
| » Lost to Cubs (21-16), 1-0 | Wrigley Field (0-2) | 16-17 | |
| » Starters: Larry Jackson vs Paul Minner | Fifth | 10 out |
| » Lost to Cubs (22-16), 3-1 | Wrigley Field (0-3) | 16-18 | Lost 2 |
| » Starters: Brooks Lawrence vs Bob Rush | Fifth | 10 out |
| Thursday, May 26 |
| » Lost to Cubs (23-16), 3-0 | Wrigley Field (0-4) | 16-19 | Lost 3 |
| » Starters: Gordon Jones vs Howie Pollet | Sixth | 11 out |
| Friday, May 27 |
| » Defeated Reds (17-20), 7-4 | Sportsman's Park III (12-6) | 17-19 | |
| » Starters: Joe Nuxhall vs Luis Arroyo | Fifth | 10 out |
| Saturday, May 28 |
| » Lost to Reds (18-20), 5-1 | Sportsman's Park III (12-7) | 17-20 | |
| » Manager: Harry Walker |
| » Starters: Jackie Collum vs Harvey Haddix | Sixth | 11 out |
| Sunday, May 29 |
| » Defeated Reds (18-21), 7-2 | Sportsman's Park III (13-7) | 18-20 | |
| » Starters: Rudy Minarcin vs Tom Poholsky | Fourth | 11 out |
| Monday, May 30 |
| » Lost to Cubs (26-17), 9-5 | Sportsman's Park III (13-8) | 18-21 | |
| » Starters: Paul Minner vs Gordon Jones | Fifth | 13 out |
| » Lost to Cubs (27-17), 4-3 | Sportsman's Park III (13-9) | 18-22 | Lost 2 |
| » Starters: Jim Davis vs Larry Jackson | Fifth | 13 out |
| Wednesday, June 1 |
| » Defeated Pirates (14-32), 6-2 | Forbes Field (2-2) | 19-22 | |
| » Starters: Luis Arroyo vs Bob Purkey | Fifth | 12½ out |
| Thursday, June 2 |
| » Lost to Pirates (15-32), 12-3 | Forbes Field (2-3) | 19-23 | |
| » Starters: Harvey Haddix vs Max Surkont | Fifth | 13½ out |
| Friday, June 3 |
| » Lost to Dodgers (35-11), 12-5 | Ebbets Field (0-3) | 19-24 | Lost 2 |
| » Starters: Tom Poholsky vs Johnny Podres | Fifth | 14½ out |
| Saturday, June 4 |
| » Lost to Dodgers (36-11), 6-1 | Ebbets Field (0-4) | 19-25 | Lost 3 |
| » Starters: Larry Jackson vs Don Newcombe | Sixth | 15½ out |
| Sunday, June 5 |
| » Defeated Dodgers (36-12), 9-4 | Ebbets Field (1-4) | 20-25 | |
| » Starters: Gordon Jones vs Carl Erskine | Sixth | 15½ out |
| » Lost to Dodgers (37-12), 10-6 | Ebbets Field (1-5) | 20-26 | |
| » Starters: Brooks Lawrence vs Karl Spooner | Sixth | 15½ out |
| » Major-league debuts: Nelson Burbrink (Cardinals) |
| Monday, June 6 |
| » Lost to Dodgers (38-12), 5-4 | Ebbets Field (1-6) | 20-27 | Lost 2 |
| » Starters: Luis Arroyo vs Billy Loes | Sixth | 16½ out |
| Tuesday, June 7 |
| » Defeated Phillies (22-31), 5-4 | Shibe Park (1-0) | 21-27 | |
| » Starters: Harvey Haddix vs Curt Simmons | Fifth | 16½ out |
| Thursday, June 9 |
| » Lost to Phillies (23-31), 2-0 | Shibe Park (1-1) | 21-28 | |
| » Starters: Larry Jackson vs Robin Roberts | Fifth | 17½ out |
| Friday, June 10 |
| » Lost to Giants (28-26), 2-1 | Polo Grounds V (1-2) | 21-29 | Lost 2 |
| » Starters: Luis Arroyo vs Jim Hearn | Seventh | 18½ out |
| Sunday, June 12 |
| » Lost to Giants (29-26), 8-3 | Polo Grounds V (1-3) | 21-30 | Lost 3 |
| » Starters: Herb Moford vs Johnny Antonelli | Sixth | 19 out |
| » Defeated Giants (29-27), 6-5 | Polo Grounds V (2-3) | 22-30 | |
| » Starters: Harvey Haddix vs Sal Maglie | Sixth | 19 out |
| Tuesday, June 14 |
| » Lost to Pirates (20-38), 10-5 | Sportsman's Park III (13-10) | 22-31 | |
| » Starters: Ron Kline vs Larry Jackson | Seventh | 20 out |
| Wednesday, June 15 |
| » Defeated Pirates (20-39), 7-3 | Sportsman's Park III (14-10) | 23-31 | |
| » Starters: Bob Friend vs Luis Arroyo | Seventh | 19 out |
| Thursday, June 16 |
| » Defeated Pirates (20-40), 5-0 | Sportsman's Park III (15-10) | 24-31 | Won 2 |
| » Starters: Vern Law vs Harvey Haddix | Seventh | 18 out |
| Friday, June 17 |
| » Lost to Dodgers (45-15), 12-1 | Sportsman's Park III (15-11) | 24-32 | |
| » Starters: Don Newcombe vs Gordon Jones | Seventh | 19 out |
| Saturday, June 18 |
| » Defeated Dodgers (45-16), 5-4 | Sportsman's Park III (16-11) | 25-32 | |
| » Starters: Johnny Podres vs Larry Jackson | Sixth | 18 out |
| Sunday, June 19 |
| » Lost to Dodgers (46-16), 7-4 | Sportsman's Park III (16-12) | 25-33 | |
| » Starters: Carl Erskine vs Floyd Wooldridge | Seventh | 19 out |
| Monday, June 20 |
| » Defeated Phillies (28-35), 4-1 | Sportsman's Park III (17-12) | 26-33 | |
| » Starters: Murry Dickson vs Luis Arroyo | Seventh | 18½ out |
| Tuesday, June 21 |
| » Lost to Phillies (29-35), 10-8 | Sportsman's Park III (17-13) | 26-34 | |
| » Starters: Curt Simmons vs Harvey Haddix | Seventh | 19½ out |
| Wednesday, June 22 |
| » Lost to Phillies (30-35), 9-6 | Sportsman's Park III (17-14) | 26-35 | Lost 2 |
| » Starters: Robin Roberts vs Larry Jackson | Seventh | 20½ out |
| Thursday, June 23 |
| » Defeated Phillies (30-36), 7-1 | Sportsman's Park III (18-14) | 27-35 | |
| » Starters: Herm Wehmeier vs Floyd Wooldridge | Seventh | 20½ out |
| Friday, June 24 |
| » Lost to Giants (33-33), 1-0 | Sportsman's Park III (18-15) | 27-36 | |
| » Starters: Ruben Gomez vs Tom Poholsky | Seventh | 20½ out |
| Saturday, June 25 |
| » Defeated Giants (33-34), 5-3 | Sportsman's Park III (19-15) | 28-36 | |
| » Starters: Jim Hearn vs Luis Arroyo | Seventh | 20½ out |
| Sunday, June 26 |
| » Defeated Giants (33-35), 9-2 | Sportsman's Park III (20-15) | 29-36 | Won 2 |
| » Starters: Johnny Antonelli vs Harvey Haddix | Sixth | 19 out |
| » Defeated Giants (33-36), 7-2 | Sportsman's Park III (21-15) | 30-36 | Won 3 |
| » Starters: Ramon Monzant vs Larry Jackson | Sixth | 19 out |
| Tuesday, June 28 |
| » Lost to Reds (32-34), 9-1 | Sportsman's Park III (21-16) | 30-37 | |
| » Starters: Joe Nuxhall vs Floyd Wooldridge | Sixth | 20 out |
| Wednesday, June 29 |
| » Defeated Reds (32-35), 9-5 | Sportsman's Park III (22-16) | 31-37 | |
| » Starters: Rudy Minarcin vs Tom Poholsky | Sixth | 19 out |
| Friday, July 1 |
| » Lost to Cubs (41-34), 11-7 | Wrigley Field (0-5) | 31-38 | |
| » Starters: Luis Arroyo vs Bob Rush | Seventh | 19½ out |
| Saturday, July 2 |
| » Lost to Cubs (42-34), 4-3 | Wrigley Field (0-6) | 31-39 | Lost 2 |
| » Starters: Larry Jackson vs Paul Minner | Seventh | 19½ out |
| Sunday, July 3 |
| » Defeated Cubs (42-35), 8-2 | Wrigley Field (1-6) | 32-39 | |
| » Starters: Floyd Wooldridge vs Jim Davis | Sixth | 19½ out |
| » Lost to Cubs (43-35), 10-5 | Wrigley Field (1-7) | 32-40 | |
| » Starters: Harvey Haddix vs Sam Jones | Sixth | 19½ out |
| Future Cardinal Matt Keough is born in Pomona, CA. |
| Monday, July 4 |
| » Defeated Braves (40-35), 4-2 | County Stadium (2-1) | 33-40 | |
| » Starters: Tom Poholsky vs Ray Crone | Sixth | 19½ out |
| » Defeated Braves (40-36), 5-4 | County Stadium (3-1) | 34-40 | Won 2 |
| » Starters: Brooks Lawrence vs Lew Burdette | Sixth | 19½ out |
| Tuesday, July 5 |
| » Lost to Reds (36-37), 5-4 | Crosley Field (2-4) | 34-41 | |
| » Starters: Luis Arroyo vs Gerry Staley | Sixth | 19½ out |
| Wednesday, July 6 |
| » Defeated Reds (36-38), 6-4 | Crosley Field (3-4) | 35-41 | |
| » Starters: Larry Jackson vs Jackie Collum | Sixth | 19 out |
| Thursday, July 7 |
| » Defeated Reds (36-39), 9-8 | Crosley Field (4-4) | 36-41 | Won 2 |
| » Starters: Harvey Haddix vs Joe Nuxhall | Sixth | 19 out |
| Friday, July 8 |
| » Lost to Cubs (45-38), 6-4 | Sportsman's Park III (22-17) | 36-42 | |
| » Starters: Paul Minner vs Floyd Wooldridge | Sixth | 20 out |
| Saturday, July 9 |
| » Defeated Cubs (45-39), 4-2 | Sportsman's Park III (23-17) | 37-42 | |
| » Starters: Warren Hacker vs Tom Poholsky | Fifth | 19 out |
| Sunday, July 10 |
| » Defeated Cubs (45-40), 7-2 | Sportsman's Park III (24-17) | 38-42 | Won 2 |
| » Starters: Howie Pollet vs Luis Arroyo | Fifth | 18 out |
| Thursday, July 14 |
| » Defeated Dodgers (58-27), 6-1 | Ebbets Field (2-6) | 39-42 | Won 3 |
| » Starters: Larry Jackson vs Johnny Podres | Fifth | 17 out |
| Friday, July 15 |
| » Lost to Dodgers (59-27), 12-3 | Ebbets Field (2-7) | 39-43 | |
| » Starters: Tom Poholsky vs Don Newcombe | Fifth | 18 out |
| Saturday, July 16 |
| » Lost to Pirates (31-59), 5-1 | Forbes Field (2-4) | 39-44 | Lost 2 |
| » Starters: Luis Arroyo vs Lino Donoso | Fifth | 19 out |
| Sunday, July 17 |
| » Defeated Pirates (31-60), 9-8 | Forbes Field (3-4) | 40-44 | |
| » Starters: Floyd Wooldridge vs Dick Littlefield | Fifth | 19 out |
| » Defeated Pirates (31-61), 1-0 | Forbes Field (4-4) | 41-44 | Won 2 |
| » Starters: Harvey Haddix vs Roy Face | Fifth | 19 out |
| Tuesday, July 19 |
| » Defeated Giants (46-44), 3-1 | Polo Grounds V (3-3) | 42-44 | Won 3 |
| » Starters: Willard Schmidt vs Jim Hearn | Fifth | 18½ out |
| » Lost to Giants (47-44), 4-2 | Polo Grounds V (3-4) | 42-45 | |
| » Starters: Larry Jackson vs Windy McCall | Fifth | 18½ out |
| Wednesday, July 20 |
| » Defeated Giants (47-45), 9-2 | Polo Grounds V (4-4) | 43-45 | |
| » Starters: Tom Poholsky vs Johnny Antonelli | Fifth | 18 out |
| Thursday, July 21 |
| » Lost to Giants (48-45), 6-5 | Polo Grounds V (4-5) | 43-46 | |
| » Starters: Luis Arroyo vs Sal Maglie | Sixth | 19 out |
| Friday, July 22 |
| » Lost to Phillies (48-48), 6-3 | Shibe Park (1-2) | 43-47 | Lost 2 |
| » Starters: Floyd Wooldridge vs Murry Dickson | Fifth | 19½ out |
| » Defeated Phillies (48-49), 8-1 | Shibe Park (2-2) | 44-47 | |
| » Starters: Harvey Haddix vs Herm Wehmeier | Fifth | 19½ out |
| Saturday, July 23 |
| » Lost to Phillies (49-49), 7-2 | Shibe Park (2-3) | 44-48 | |
| » Starters: Willard Schmidt vs Robin Roberts | Sixth | 19½ out |
| Sunday, July 24 |
| » Lost to Phillies (50-49), 6-5 | Shibe Park (2-4) | 44-49 | Lost 2 |
| » Starters: Larry Jackson vs Curt Simmons | Sixth | 20½ out |
| » Lost to Phillies (51-49), 3-0 | Shibe Park (2-5) | 44-50 | Lost 3 |
| » Starters: Tom Poholsky vs Saul Rogovin | Sixth | 20½ out |
| Tuesday, July 26 |
| » Lost to Pirates (38-62), 3-1 | Sportsman's Park III (24-18) | 44-51 | Lost 4 |
| » Starters: Dick Littlefield vs Luis Arroyo | Sixth | 21½ out |
| Wednesday, July 27 |
| » Defeated Pirates (38-63), 6-1 | Sportsman's Park III (25-18) | 45-51 | |
| » Starters: Roy Face vs Harvey Haddix | Sixth | 20½ out |
| Thursday, July 28 |
| » Defeated Pirates (38-64), 4-1 | Sportsman's Park III (26-18) | 46-51 | Won 2 |
| » Starters: Dick Hall vs Willard Schmidt | Fifth | 20½ out |
| Friday, July 29 |
| » Lost to Dodgers (69-32), 5-4 | Sportsman's Park III (26-19) | 46-52 | |
| » Starters: Karl Spooner vs Larry Jackson | Fifth | 21½ out |
| Saturday, July 30 |
| » Lost to Dodgers (70-32), 6-0 | Sportsman's Park III (26-20) | 46-53 | Lost 2 |
| » Starters: Johnny Podres vs Tom Poholsky | Fifth | 22½ out |
| Sunday, July 31 |
| » Lost to Dodgers (71-32), 11-2 | Sportsman's Park III (26-21) | 46-54 | Lost 3 |
| » Starters: Don Newcombe vs Luis Arroyo | Sixth | 23½ out |
| Monday, August 1 |
| » Lost to Giants (55-50), 9-1 | Sportsman's Park III (26-22) | 46-55 | Lost 4 |
| » Starters: Don Liddle vs Harvey Haddix | Seventh | 24½ out |
| Tuesday, August 2 |
| » Lost to Giants (56-50), 3-0 | Sportsman's Park III (26-23) | 46-56 | Lost 5 |
| » Starters: Johnny Antonelli vs Willard Schmidt | Seventh | 24½ out |
| Wednesday, August 3 |
| » Lost to Giants (57-50), 5-3 | Sportsman's Park III (26-24) | 46-57 | Lost 6 |
| » Starters: Windy McCall vs Larry Jackson | Seventh | 25½ out |
| Thursday, August 4 |
| » Defeated Giants (57-51), 3-0 | Sportsman's Park III (27-24) | 47-57 | |
| » Starters: Ramon Monzant vs Tom Poholsky | Seventh | 25½ out |
| Friday, August 5 |
| » Lost to Phillies (55-58), 7-4 | Sportsman's Park III (27-25) | 47-58 | |
| » Starters: Curt Simmons vs Luis Arroyo | Seventh | 25½ out |
| Saturday, August 6 |
| » Lost to Phillies (56-58), 5-3 | Sportsman's Park III (27-26) | 47-59 | Lost 2 |
| » Starters: Murry Dickson vs Harvey Haddix | Seventh | 26 out |
| Sunday, August 7 |
| » Lost to Phillies (57-58), 9-6 | Sportsman's Park III (27-27) | 47-60 | Lost 3 |
| » Starters: Robin Roberts vs Willard Schmidt | Seventh | 26 out |
| Tuesday, August 9 |
| » Lost to Braves (61-50), 6-2 | County Stadium (3-2) | 47-61 | Lost 4 |
| » Starters: Larry Jackson vs Warren Spahn | Seventh | 26½ out |
| Wednesday, August 10 |
| » Defeated Braves (61-51), 7-2 | County Stadium (4-2) | 48-61 | |
| » Starters: Tom Poholsky vs Lew Burdette | Seventh | 26½ out |
| Thursday, August 11 |
| » Defeated Braves (61-52), 7-1 | County Stadium (5-2) | 49-61 | Won 2 |
| » Starters: Harvey Haddix vs Chet Nichols | Seventh | 25½ out |
| » Defeated Braves (61-53), 4-0 | County Stadium (6-2) | 50-61 | Won 3 |
| » Starters: Willard Schmidt vs Bob Buhl | Seventh | 25½ out |
| Future Cardinal Bryn Smith is born in Marietta, GA. |
| Friday, August 12 |
| » Defeated Reds (55-61), 8-7 | Sportsman's Park III (28-27) | 51-61 | Won 4 |
| » Starters: Joe Nuxhall vs Luis Arroyo | Seventh | 25 out |
| Saturday, August 13 |
| » Lost to Reds (56-61), 5-4 | Sportsman's Park III (28-28) | 51-62 | |
| » Starters: Jackie Collum vs Larry Jackson | Seventh | 25½ out |
| Sunday, August 14 |
| » Defeated Reds (56-62), 5-4 | Sportsman's Park III (29-28) | 52-62 | |
| » Starters: Art Fowler vs Tom Poholsky | Seventh | 25 out |
| Monday, August 15 |
| » Lost to Braves (64-54), 12-1 | Sportsman's Park III (29-29) | 52-63 | |
| » Starters: Warren Spahn vs Willard Schmidt | Seventh | 25½ out |
| Tuesday, August 16 |
| » Defeated Braves (64-55), 3-2 | Sportsman's Park III (30-29) | 53-63 | |
| » Starters: Chet Nichols vs Harvey Haddix | Seventh | 24½ out |
| » Major-league debuts: Bob Roselli (Braves) |
| Wednesday, August 17 |
| » Lost to Braves (65-55), 11-4 | Sportsman's Park III (30-30) | 53-64 | |
| » Starters: Bob Buhl vs Luis Arroyo | Seventh | 24½ out |
| Thursday, August 18 |
| » Lost to Braves (66-55), 5-3 | Sportsman's Park III (30-31) | 53-65 | Lost 2 |
| » Starters: Warren Spahn vs Larry Jackson | Seventh | 25½ out |
| Friday, August 19 |
| » Lost to Reds (59-63), 7-5 | Crosley Field (4-5) | 53-66 | Lost 3 |
| » Starters: Tom Poholsky vs Joe Nuxhall | Seventh | 25½ out |
| Future Cardinal Silvio Martinez is born in Santiago, D.R. |
| Saturday, August 20 |
| » Lost to Reds (60-63), 7-4 | Crosley Field (4-6) | 53-67 | Lost 4 |
| » Starters: Luis Arroyo vs Joe Black | Seventh | 25½ out |
| Sunday, August 21 |
| » Lost to Reds (61-63), 4-0 | Crosley Field (4-7) | 53-68 | Lost 5 |
| » Starters: Harvey Haddix vs Don Gross | Seventh | 25½ out |
| Tuesday, August 23 |
| » Defeated Giants (64-58), 2-1 | Polo Grounds V (5-5) | 54-68 | |
| » Starters: Willard Schmidt vs Johnny Antonelli | Seventh | 25½ out |
| Wednesday, August 24 |
| » Lost to Giants (65-58), 4-1 | Polo Grounds V (5-6) | 54-69 | |
| » Starters: Tom Poholsky vs Don Liddle | Seventh | 26½ out |
| Thursday, August 25 |
| » Lost to Phillies (65-61), 11-9 | Shibe Park (2-6) | 54-70 | Lost 2 |
| » Starters: John Mackinson vs Robin Roberts | Seventh | 26½ out |
| » Lost to Phillies (66-61), 8-3 | Shibe Park (2-7) | 54-71 | Lost 3 |
| » Starters: Harvey Haddix vs Saul Rogovin | Seventh | 26½ out |
| Friday, August 26 |
| » Defeated Phillies (66-62), 4-1 | Shibe Park (3-7) | 55-71 | |
| » Starters: Willard Schmidt vs Curt Simmons | Seventh | 25½ out |
| Saturday, August 27 |
| » Lost to Phillies (67-62), 8-2 | Shibe Park (3-8) | 55-72 | |
| » Starters: Luis Arroyo vs Murry Dickson | Seventh | 26½ out |
| Sunday, August 28 |
| » Lost to Dodgers (82-45), 6-1 | Ebbets Field (2-8) | 55-73 | Lost 2 |
| » Starters: Larry Jackson vs Karl Spooner | Seventh | 27½ out |
| Monday, August 29 |
| » Lost to Dodgers (83-45), 10-4 | Ebbets Field (2-9) | 55-74 | Lost 3 |
| » Starters: Tom Poholsky vs Johnny Podres | Seventh | 28½ out |
| Tuesday, August 30 |
| » Lost to Pirates (51-80), 3-1 | Forbes Field (4-5) | 55-75 | Lost 4 |
| » Starters: Harvey Haddix vs Dick Littlefield | Seventh | 29½ out |
| Wednesday, August 31 |
| » Lost to Pirates (52-80), 4-3 | Forbes Field (4-6) | 55-76 | Lost 5 |
| » Starters: Willard Schmidt vs Lino Donoso | Seventh | 29½ out |
| Thursday, September 1 |
| » Lost to Pirates (53-80), 7-6 | Forbes Field (4-7) | 55-77 | Lost 6 |
| » Starters: Luis Arroyo vs Vern Law | Seventh | 30½ out |
| Friday, September 2 |
| » Lost to Cubs (65-72), 12-2 | Wrigley Field (1-8) | 55-78 | Lost 7 |
| » Starters: Tom Poholsky vs Paul Minner | Seventh | 31½ out |
| » Major-league debuts: Lindy McDaniel (Cardinals) |
| Saturday, September 3 |
| » Defeated Cubs (65-73), 3-2 | Wrigley Field (2-8) | 56-78 | |
| » Starters: Harvey Haddix vs Bob Rush | Seventh | 31½ out |
| Sunday, September 4 |
| » Lost to Cubs (66-73), 4-3 | Wrigley Field (2-9) | 56-79 | |
| » Starters: Willard Schmidt vs Jim Davis | Seventh | 32½ out |
| Monday, September 5 |
| » Defeated Reds (67-74), 3-2 | Sportsman's Park III (31-31) | 57-79 | |
| » Starters: Joe Nuxhall vs Tom Poholsky | Sixth | 33 out |
| Wednesday, September 7 |
| » Lost to Giants (72-66), 8-2 | Sportsman's Park III (31-32) | 57-80 | |
| » Starters: Johnny Antonelli vs Larry Jackson | Seventh | 34 out |
| Thursday, September 8 |
| » Lost to Giants (73-66), 6-2 | Sportsman's Park III (31-33) | 57-81 | Lost 2 |
| » Starters: Windy McCall vs Harvey Haddix | Seventh | 35 out |
| Friday, September 9 |
| » Defeated Phillies (72-70), 11-2 | Sportsman's Park III (32-33) | 58-81 | |
| » Starters: Murry Dickson vs Willard Schmidt | Seventh | 34½ out |
| Saturday, September 10 |
| » Defeated Phillies (72-71), 4-3 | Sportsman's Park III (33-33) | 59-81 | Won 2 |
| » Starters: Robin Roberts vs Tom Poholsky | Seventh | 34 out |
| Sunday, September 11 |
| » Defeated Pirates (55-87), 6-5 | Sportsman's Park III (34-33) | 60-81 | Won 3 |
| » Starters: Dick Littlefield vs Ben Flowers | Seventh | 32½ out |
| Monday, September 12 |
| » Lost to Pirates (56-87), 9-3 | Sportsman's Park III (34-34) | 60-82 | |
| » Starters: Lino Donoso vs Harvey Haddix | Seventh | 33 out |
| Tuesday, September 13 |
| » Defeated Dodgers (93-50), 8-2 | Sportsman's Park III (35-34) | 61-82 | |
| » Starters: Karl Spooner vs Willard Schmidt | Seventh | 32 out |
| Wednesday, September 14 |
| » Defeated Dodgers (93-51), 3-0 | Sportsman's Park III (36-34) | 62-82 | Won 2 |
| » Starters: Carl Erskine vs Tom Poholsky | Seventh | 31 out |
| Thursday, September 15 |
| » Defeated Dodgers (93-52), 3-2 | Sportsman's Park III (37-34) | 63-82 | Won 3 |
| » Starters: Sandy Koufax vs Ben Flowers | Seventh | 30 out |
| Friday, September 16 |
| » Lost to Braves (82-65), 9-4 | County Stadium (6-3) | 63-83 | |
| » Starters: Brooks Lawrence vs Lew Burdette | Seventh | 31 out |
| Future Cardinal Joe Edelen is born in Durant, OK. |
| Saturday, September 17 |
| » Defeated Braves (82-66), 4-1 | County Stadium (7-3) | 64-83 | |
| » Starters: Willard Schmidt vs Humberto Robinson | Seventh | 30 out |
| Sunday, September 18 |
| » Lost to Braves (83-66), 2-1 | County Stadium (7-4) | 64-84 | |
| » Starters: Tom Poholsky vs Warren Spahn | Seventh | 31 out |
| Monday, September 19 |
| » Defeated Cubs (70-79), 6-5 | Sportsman's Park III (38-34) | 65-84 | |
| » Starters: Paul Minner vs Lindy McDaniel | Seventh | 30½ out |
| Tuesday, September 20 |
| » Defeated Cubs (70-80), 2-0 | Sportsman's Park III (39-34) | 66-84 | Won 2 |
| » Starters: Sam Jones vs Ben Flowers | Seventh | 31 out |
| » Major-league debuts: Don Blasingame (Cardinals) |
| Wednesday, September 21 |
| » Lost to Cubs (71-80), 7-5 | Sportsman's Park III (39-35) | 66-85 | |
| » Starters: Bob Rush vs Willard Schmidt | Seventh | 31½ out |
| Friday, September 23 |
| » Lost to Braves (85-67), 4-2 | Sportsman's Park III (39-36) | 66-86 | Lost 2 |
| » Starters: Warren Spahn vs Tom Poholsky | Seventh | 32 out |
| Saturday, September 24 |
| » Defeated Braves (85-68)</ |
