| Tuesday, April 13 |
| » Defeated Yankees (0-1), 5-3 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Whitey Ford vs Chuck Stobbs | First | -- |
| » Major-league debuts: Bill Skowron (Yankees) |
| Wednesday, April 14 |
| » Lost to Yankees (1-1), 2-1 | Griffith Stadium (1-1) | 1-1 | |
| » Starters: Ed Lopat vs Johnny Schmitz | Third | 1 out |
| Thursday, April 15 |
| » Lost to Red Sox (1-1), 6-1 | Fenway Park (0-1) | 1-2 | Lost 2 |
| » Starters: Bob Porterfield vs Bill Henry | Third | 1 out |
| Sunday, April 18 |
| » Defeated Yankees (2-2), 9-3 | Yankee Stadium (1-0) | 2-2 | |
| » Starters: Mickey McDermott vs Bob Grim | Second | 1½ out |
| » Major-league debuts: Bob Grim (Yankees) |
| Monday, April 19 |
| » Defeated Athletics (2-3), 4-3 | Griffith Stadium (2-1) | 3-2 | Won 2 |
| » Starters: Morrie Martin vs Spec Shea | Second | ½ out |
| Tuesday, April 20 |
| » Lost to Athletics (3-3), 7-0 | Griffith Stadium (2-2) | 3-3 | |
| » Starters: Alex Kellner vs Chuck Stobbs | Second | ½ out |
| Wednesday, April 21 |
| » Defeated Athletics (3-4), 13-1 | Shibe Park (1-0) | 4-3 | |
| » Starters: Bob Porterfield vs Marion Fricano | First | -- |
| Friday, April 23 |
| » Defeated Red Sox (3-5), 7-6 | Griffith Stadium (3-2) | 5-3 | Won 2 |
| » Starters: Bill Henry vs Spec Shea | First | -- |
| Saturday, April 24 |
| » Lost to Red Sox (4-5), 6-1 | Griffith Stadium (3-3) | 5-4 | |
| » Starters: Mel Parnell vs Mickey McDermott | Second | 1 out |
| Sunday, April 25 |
| » Defeated Red Sox (4-6), 5-1 | Griffith Stadium (4-3) | 6-4 | |
| » Starters: Leo Kiely vs Chuck Stobbs | Second | ½ out |
| Thursday, April 29 |
| » Lost to Orioles (5-7), 2-1 | Griffith Stadium (4-4) | 6-5 | |
| » Starters: Bob Turley vs Mickey McDermott | Third | 1 out |
| Friday, April 30 |
| » Lost to Tigers (7-4), 2-1 | Griffith Stadium (4-5) | 6-6 | Lost 2 |
| » Starters: Ned Garver vs Bob Porterfield | Fourth | 2 out |
| Saturday, May 1 |
| » Lost to Tigers (8-4), 6-1 | Griffith Stadium (4-6) | 6-7 | Lost 3 |
| » Starters: Steve Gromek vs Spec Shea | Fifth | 3 out |
| Sunday, May 2 |
| » Lost to Indians (8-6), 6-4 | Griffith Stadium (4-7) | 6-8 | Lost 4 |
| » Starters: Bob Feller vs Chuck Stobbs | Sixth | 4 out |
| » Lost to Indians (9-6), 6-3 | Griffith Stadium (4-8) | 6-9 | Lost 5 |
| » Starters: Art Houtteman vs Johnny Schmitz | Sixth | 4 out |
| Tuesday, May 4 |
| » Lost to White Sox (13-6), 8-6 | Griffith Stadium (4-9) | 6-10 | Lost 6 |
| » Starters: Billy Pierce vs Mickey McDermott | Fifth | 5½ out |
| Wednesday, May 5 |
| » Defeated White Sox (13-7), 1-0 | Griffith Stadium (5-9) | 7-10 | |
| » Starters: Bob Keegan vs Bob Porterfield | Sixth | 4½ out |
| Thursday, May 6 |
| » Lost to White Sox (14-7), 5-4 | Griffith Stadium (5-10) | 7-11 | |
| » Starters: Virgil Trucks vs Camilo Pascual | Fifth | 5½ out |
| Friday, May 7 |
| » Lost to Red Sox (5-9), 7-6 | Fenway Park (0-2) | 7-12 | Lost 2 |
| » Starters: Spec Shea vs Tex Clevenger | Sixth | 6 out |
| Tuesday, May 11 |
| » Defeated Tigers (11-6), 5-3 | Tiger Stadium (1-0) | 8-12 | |
| » Starters: Bob Porterfield vs Ralph Branca | Sixth | 4½ out |
| Wednesday, May 12 |
| » Lost to Tigers (12-6), 4-2 | Tiger Stadium (1-1) | 8-13 | |
| » Starters: Camilo Pascual vs Ted Gray | Sixth | 5½ out |
| Thursday, May 13 |
| » Lost to Indians (14-10), 8-7 | Cleveland Stadium (0-1) | 8-14 | Lost 2 |
| » Starters: Mickey McDermott vs Art Houtteman | Sixth | 5½ out |
| Friday, May 14 |
| » Lost to Indians (15-10), 5-2 | Cleveland Stadium (0-2) | 8-15 | Lost 3 |
| » Starters: Chuck Stobbs vs Bob Lemon | Sixth | 7 out |
| Saturday, May 15 |
| » Lost to Indians (16-10), 5-4 | Cleveland Stadium (0-3) | 8-16 | Lost 4 |
| » Starters: Spec Shea vs Early Wynn | Sixth | 8 out |
| Sunday, May 16 |
| » Lost to White Sox (19-10), 10-5 | Comiskey Park I (0-1) | 8-17 | Lost 5 |
| » Starters: Connie Marrero vs Bob Keegan | Seventh | 8 out |
| » Defeated White Sox (19-11), 3-1 | Comiskey Park I (1-1) | 9-17 | |
| » Starters: Bob Porterfield vs Mike Fornieles | Seventh | 8 out |
| Tuesday, May 18 |
| » Defeated Orioles (11-15), 3-1 | Memorial Stadium (1-0) | 10-17 | Won 2 |
| » Starters: Mickey McDermott vs Bob Turley | Sixth | 8 out |
| Wednesday, May 19 |
| » Lost to Orioles (12-15), 5-3 | Memorial Stadium (1-1) | 10-18 | |
| » Starters: Chuck Stobbs vs Joe Coleman | Sixth | 9 out |
| Friday, May 21 |
| » Defeated Athletics (10-20), 7-3 | Griffith Stadium (6-10) | 11-18 | |
| » Starters: Art Ditmar vs Bob Porterfield | Sixth | 9 out |
| Saturday, May 22 |
| » Lost to Athletics (11-20), 10-3 | Griffith Stadium (6-11) | 11-19 | |
| » Starters: Arnie Portocarrero vs Spec Shea | Sixth | 10 out |
| Sunday, May 23 |
| » Defeated Athletics (11-21), 9-4 | Griffith Stadium (7-11) | 12-19 | |
| » Starters: Bob Trice vs Connie Marrero | Fifth | 10½ out |
| Tuesday, May 25 |
| » Lost to Yankees (22-13), 9-3 | Griffith Stadium (7-12) | 12-20 | |
| » Starters: Whitey Ford vs Mickey McDermott | Fifth | 10½ out |
| Wednesday, May 26 |
| » Defeated Yankees (22-14), 2-1 | Griffith Stadium (8-12) | 13-20 | |
| » Starters: Ed Lopat vs Bob Porterfield | Fifth | 9½ out |
| Thursday, May 27 |
| » Defeated Yankees (22-15), 7-3 | Griffith Stadium (9-12) | 14-20 | Won 2 |
| » Starters: Bob Kuzava vs Chuck Stobbs | Fifth | 9 out |
| Friday, May 28 |
| » Defeated Athletics (12-24), 12-6 | Shibe Park (2-0) | 15-20 | Won 3 |
| » Starters: Dean Stone vs Bob Trice | Fifth | 9 out |
| Saturday, May 29 |
| » Lost to Athletics (13-24), 7-5 | Shibe Park (2-1) | 15-21 | |
| » Starters: Spec Shea vs Alex Kellner | Fifth | 10 out |
| Sunday, May 30 |
| » Defeated Athletics (13-25), 6-0 | Shibe Park (3-1) | 16-21 | |
| » Starters: Mickey McDermott vs Marion Fricano | Fifth | 10½ out |
| » Lost to Athletics (14-25), 6-5 | Shibe Park (3-2) | 16-22 | |
| » Starters: Bob Porterfield vs Arnie Portocarrero | Fifth | 10½ out |
| Monday, May 31 |
| » Defeated Yankees (24-17), 1-0 | Yankee Stadium (2-0) | 17-22 | |
| » Starters: Johnny Schmitz vs Whitey Ford | Fifth | 10½ out |
| » Lost to Yankees (25-17), 7-6 | Yankee Stadium (2-1) | 17-23 | |
| » Starters: Bunky Stewart vs Bob Kuzava | Fifth | 10½ out |
| Tuesday, June 1 |
| » Lost to Yankees (26-17), 9-3 | Yankee Stadium (2-2) | 17-24 | Lost 2 |
| » Starters: Chuck Stobbs vs Bob Grim | Fifth | 11 out |
| Wednesday, June 2 |
| » Defeated Tigers (21-18), 7-2 | Griffith Stadium (10-12) | 18-24 | |
| » Starters: Steve Gromek vs Dean Stone | Fifth | 11 out |
| Thursday, June 3 |
| » Defeated Tigers (21-19), 4-3 | Griffith Stadium (11-12) | 19-24 | Won 2 |
| » Starters: Ned Garver vs Mickey McDermott | Fifth | 10 out |
| Friday, June 4 |
| » Lost to Tigers (22-19), 3-2 | Griffith Stadium (11-13) | 19-25 | |
| » Starters: Billy Hoeft vs Bob Porterfield | Fifth | 10 out |
| Saturday, June 5 |
| » Lost to White Sox (31-16), 5-3 | Griffith Stadium (11-14) | 19-26 | Lost 2 |
| » Starters: Don Johnson vs Johnny Schmitz | Fifth | 11 out |
| Sunday, June 6 |
| » Lost to White Sox (32-16), 5-3 | Griffith Stadium (11-15) | 19-27 | Lost 3 |
| » Starters: Sandy Consuegra vs Chuck Stobbs | Fifth | 13 out |
| » Lost to White Sox (33-16), 6-0 | Griffith Stadium (11-16) | 19-28 | Lost 4 |
| » Starters: Jack Harshman vs Camilo Pascual | Fifth | 13 out |
| Tuesday, June 8 |
| » Defeated Indians (32-16), 5-2 | Griffith Stadium (12-16) | 20-28 | |
| » Starters: Early Wynn vs Mickey McDermott | Fifth | 13 out |
| Wednesday, June 9 |
| » Lost to Indians (33-16), 1-0 | Griffith Stadium (12-17) | 20-29 | |
| » Starters: Mike Garcia vs Bob Porterfield | Sixth | 14 out |
| Thursday, June 10 |
| » Defeated Indians (33-17), 8-4 | Griffith Stadium (13-17) | 21-29 | |
| » Starters: Bob Lemon vs Dean Stone | Fifth | 13½ out |
| Friday, June 11 |
| » Defeated Orioles (20-33), 9-8 | Griffith Stadium (14-17) | 22-29 | Won 2 |
| » Starters: Bob Chakales vs Johnny Schmitz | Fifth | 12½ out |
| Saturday, June 12 |
| » Lost to Orioles (21-33), 7-3 | Griffith Stadium (14-18) | 22-30 | |
| » Starters: Lou Kretlow vs Chuck Stobbs | Fifth | 13 out |
| Sunday, June 13 |
| » Lost to Orioles (22-33), 6-4 | Griffith Stadium (14-19) | 22-31 | Lost 2 |
| » Starters: Bob Turley vs Mickey McDermott | Fifth | 14 out |
| » Defeated Orioles (22-34), 4-0 | Griffith Stadium (15-19) | 23-31 | |
| » Starters: Don Larsen vs Bob Porterfield | Fifth | 14 out |
| Tuesday, June 15 |
| » Lost to Indians (39-17), 9-3 | Cleveland Stadium (0-4) | 23-32 | |
| » Starters: Dean Stone vs Art Houtteman | Fifth | 15½ out |
| Wednesday, June 16 |
| » Lost to Indians (40-17), 5-1 | Cleveland Stadium (0-5) | 23-33 | Lost 2 |
| » Starters: Mickey McDermott vs Don Mossi | Fifth | 16½ out |
| Thursday, June 17 |
| » Lost to Indians (41-17), 6-4 | Cleveland Stadium (0-6) | 23-34 | Lost 3 |
| » Starters: Spec Shea vs Early Wynn | Fifth | 17½ out |
| Friday, June 18 |
| » Defeated Orioles (22-38), 7-5 | Memorial Stadium (2-1) | 24-34 | |
| » Starters: Bob Porterfield vs Lou Kretlow | Fifth | 17½ out |
| Saturday, June 19 |
| » Defeated Orioles (22-39), 5-2 | Memorial Stadium (3-1) | 25-34 | Won 2 |
| » Starters: Johnny Schmitz vs Joe Coleman | Fifth | 16½ out |
| Sunday, June 20 |
| » Defeated Orioles (22-40), 7-1 | Memorial Stadium (4-1) | 26-34 | Won 3 |
| » Starters: Connie Marrero vs Duane Pillette | Fifth | 16½ out |
| » Defeated Orioles (22-41), 7-2 | Memorial Stadium (5-1) | 27-34 | Won 4 |
| » Starters: Dean Stone vs Bob Chakales | Fifth | 16½ out |
| » Major-league debuts: Billy O'Dell (Orioles) |
| Tuesday, June 22 |
| » Lost to White Sox (41-22), 7-5 | Comiskey Park I (1-2) | 27-35 | |
| » Starters: Mickey McDermott vs Virgil Trucks | Fifth | 16½ out |
| Wednesday, June 23 |
| » Lost to White Sox (42-22), 8-6 | Comiskey Park I (1-3) | 27-36 | Lost 2 |
| » Starters: Bob Porterfield vs Jack Harshman | Fifth | 17½ out |
| » Major-league debuts: Harmon Killebrew (Senators) |
| Thursday, June 24 |
| » Lost to White Sox (43-22), 5-2 | Comiskey Park I (1-4) | 27-37 | Lost 3 |
| » Starters: Johnny Schmitz vs Sandy Consuegra | Fifth | 17½ out |
| Friday, June 25 |
| » Defeated Tigers (28-35), 4-3 | Tiger Stadium (2-1) | 28-37 | |
| » Starters: Dean Stone vs George Zuverink | Fifth | 16½ out |
| Saturday, June 26 |
| » Lost to Tigers (29-35), 5-4 | Tiger Stadium (2-2) | 28-38 | |
| » Starters: Connie Marrero vs Al Aber | Fifth | 16½ out |
| Former Senator Charlie Pick dies in Lynchburg, VA at the age of 67. |
| Sunday, June 27 |
| » Defeated Tigers (29-36), 8-2 | Tiger Stadium (3-2) | 29-38 | |
| » Starters: Bob Porterfield vs Billy Hoeft | Fifth | 16½ out |
| Tuesday, June 29 |
| » Lost to Athletics (27-41), 3-2 | Shibe Park (3-3) | 29-39 | |
| » Starters: Mickey McDermott vs Arnie Portocarrero | Fifth | 17½ out |
| Wednesday, June 30 |
| » Lost to Athletics (28-41), 8-7 | Shibe Park (3-4) | 29-40 | Lost 2 |
| » Starters: Camilo Pascual vs Marion Fricano | Fifth | 18½ out |
| Friday, July 2 |
| » Lost to Yankees (47-27), 6-5 | Yankee Stadium (2-3) | 29-41 | Lost 3 |
| » Starters: Johnny Schmitz vs Ed Lopat | Fifth | 19½ out |
| » Defeated Yankees (47-28), 7-4 | Yankee Stadium (3-3) | 30-41 | |
| » Starters: Dean Stone vs Whitey Ford | Fifth | 19½ out |
| Saturday, July 3 |
| » Lost to Yankees (48-28), 3-2 | Yankee Stadium (3-4) | 30-42 | |
| » Starters: Bob Porterfield vs Bob Wiesler | Fifth | 20½ out |
| Sunday, July 4 |
| » Lost to Yankees (49-28), 3-0 | Yankee Stadium (3-5) | 30-43 | Lost 2 |
| » Starters: Mickey McDermott vs Bob Grim | Fifth | 21½ out |
| Monday, July 5 |
| » Lost to Red Sox (28-44), 14-0 | Griffith Stadium (15-20) | 30-44 | Lost 3 |
| » Starters: Willard Nixon vs Connie Marrero | Fifth | 21½ out |
| » Defeated Red Sox (28-45), 7-1 | Griffith Stadium (16-20) | 31-44 | |
| » Starters: Bill Henry vs Chuck Stobbs | Fifth | 21½ out |
| Tuesday, July 6 |
| » Defeated Athletics (29-46), 5-2 | Griffith Stadium (17-20) | 32-44 | Won 2 |
| » Starters: Bob Trice vs Johnny Schmitz | Fifth | 21½ out |
| Friday, July 9 |
| » Lost to Yankees (54-28), 6-5 | Griffith Stadium (17-21) | 32-45 | |
| » Starters: Ed Lopat vs Dean Stone | Fifth | 22½ out |
| Saturday, July 10 |
| » Lost to Yankees (55-28), 9-1 | Griffith Stadium (17-22) | 32-46 | Lost 2 |
| » Starters: Bob Wiesler vs Bob Porterfield | Fifth | 22½ out |
| Sunday, July 11 |
| » Lost to Yankees (56-28), 7-3 | Griffith Stadium (17-23) | 32-47 | Lost 3 |
| » Starters: Bob Grim vs Mickey McDermott | Fifth | 22 out |
| Thursday, July 15 |
| » Defeated White Sox (54-32), 3-2 | Griffith Stadium (18-23) | 33-47 | |
| » Starters: Bob Keegan vs Johnny Schmitz | Fifth | 22 out |
| Friday, July 16 |
| » Lost to White Sox (55-32), 4-2 | Griffith Stadium (18-24) | 33-48 | |
| » Starters: Virgil Trucks vs Dean Stone | Fifth | 23 out |
| Saturday, July 17 |
| » Defeated White Sox (55-33), 3-1 | Griffith Stadium (19-24) | 34-48 | |
| » Starters: Billy Pierce vs Bob Porterfield | Fifth | 23 out |
| Sunday, July 18 |
| » Defeated Indians (59-28), 8-3 | Griffith Stadium (20-24) | 35-48 | Won 2 |
| » Starters: Art Houtteman vs Chuck Stobbs | Fifth | 23 out |
| » Lost to Indians (60-28), 7-4 | Griffith Stadium (20-25) | 35-49 | |
| » Starters: Bob Lemon vs Mickey McDermott | Fifth | 23 out |
| Monday, July 19 |
| » Lost to Indians (61-28), 4-3 | Griffith Stadium (20-26) | 35-50 | Lost 2 |
| » Starters: Early Wynn vs Spec Shea | Sixth | 24 out |
| Tuesday, July 20 |
| » Defeated Orioles (32-58), 9-1 | Griffith Stadium (21-26) | 36-50 | |
| » Starters: Joe Coleman vs Johnny Schmitz | Sixth | 23½ out |
| Wednesday, July 21 |
| » Defeated Orioles (32-59), 6-5 | Griffith Stadium (22-26) | 37-50 | Won 2 |
| » Starters: Bob Turley vs Dean Stone | Fifth | 23 out |
| Thursday, July 22 |
| » Defeated Orioles (32-60), 3-2 | Griffith Stadium (23-26) | 38-50 | Won 3 |
| » Starters: Bob Chakales vs Bob Porterfield | Fifth | 23½ out |
| Friday, July 23 |
| » Defeated Tigers (40-51), 8-3 | Griffith Stadium (24-26) | 39-50 | Won 4 |
| » Starters: Al Aber vs Chuck Stobbs | Fifth | 23½ out |
| Saturday, July 24 |
| » Defeated Tigers (40-52), 2-1 | Griffith Stadium (25-26) | 40-50 | Won 5 |
| » Starters: Billy Hoeft vs Dean Stone | Fourth | 23½ out |
| Sunday, July 25 |
| » Defeated Tigers (40-53), 11-3 | Griffith Stadium (26-26) | 41-50 | Won 6 |
| » Starters: Ted Gray vs Spec Shea | Fourth | 22½ out |
| Tuesday, July 27 |
| » Lost to Orioles (34-63), 7-5 | Memorial Stadium (5-2) | 41-51 | |
| » Starters: Johnny Schmitz vs Duane Pillette | Fourth | 23½ out |
| Wednesday, July 28 |
| » Lost to Orioles (35-63), 2-1 | Memorial Stadium (5-3) | 41-52 | Lost 2 |
| » Starters: Bob Porterfield vs Joe Coleman | Fourth | 24½ out |
| Thursday, July 29 |
| » Defeated Orioles (35-64), 6-0 | Memorial Stadium (6-3) | 42-52 | |
| » Starters: Chuck Stobbs vs Billy O'Dell | Fifth | 23½ out |
| Friday, July 30 |
| » Lost to Indians (68-30), 8-3 | Cleveland Stadium (0-7) | 42-53 | |
| » Starters: Dean Stone vs Art Houtteman | Fifth | 24½ out |
| Saturday, July 31 |
| » Lost to Indians (69-30), 6-0 | Cleveland Stadium (0-8) | 42-54 | Lost 2 |
| » Starters: Spec Shea vs Bob Lemon | Fifth | 25½ out |
| Sunday, August 1 |
| » Lost to Indians (70-30), 3-1 | Cleveland Stadium (0-9) | 42-55 | Lost 3 |
| » Starters: Johnny Schmitz vs Early Wynn | Fifth | 27½ out |
| » Lost to Indians (71-30), 5-4 | Cleveland Stadium (0-10) | 42-56 | Lost 4 |
| » Starters: Bob Porterfield vs Mike Garcia | Fifth | 27½ out |
| Monday, August 2 |
| » Defeated Tigers (45-57), 11-6 | Tiger Stadium (4-2) | 43-56 | |
| » Starters: Dean Stone vs George Zuverink | Fifth | 27 out |
| Tuesday, August 3 |
| » Lost to Tigers (46-57), 2-0 | Tiger Stadium (4-3) | 43-57 | |
| » Starters: Chuck Stobbs vs Billy Hoeft | Fifth | 27 out |
| Wednesday, August 4 |
| » Lost to Tigers (47-57), 6-2 | Tiger Stadium (4-4) | 43-58 | Lost 2 |
| » Starters: Connie Marrero vs Ned Garver | Fifth | 28 out |
| Thursday, August 5 |
| » Defeated Tigers (47-58), 4-1 | Tiger Stadium (5-4) | 44-58 | |
| » Starters: Bob Porterfield vs Steve Gromek | Fifth | 27 out |
| Friday, August 6 |
| » Lost to White Sox (70-39), 10-5 | Comiskey Park I (1-5) | 44-59 | |
| » Starters: Johnny Schmitz vs Virgil Trucks | Fifth | 28 out |
| Saturday, August 7 |
| » Defeated White Sox (70-40), 4-3 | Comiskey Park I (2-5) | 45-59 | |
| » Starters: Mickey McDermott vs Sandy Consuegra | Fifth | 28 out |
| Sunday, August 8 |
| » Defeated White Sox (70-41), 7-6 | Comiskey Park I (3-5) | 46-59 | Won 2 |
| » Starters: Chuck Stobbs vs Billy Pierce | Fifth | 29 out |
| » Lost to White Sox (71-41), 3-0 | Comiskey Park I (3-6) | 46-60 | |
| » Starters: Dean Stone vs Jack Harshman | Fifth | 29 out |
| Tuesday, August 10 |
| » Lost to Red Sox (45-62), 4-0 | Fenway Park (0-3) | 46-61 | Lost 2 |
| » Starters: Bob Porterfield vs Mel Parnell | Fifth | 29 out |
| Wednesday, August 11 |
| » Lost to Red Sox (46-62), 10-1 | Fenway Park (0-4) | 46-62 | Lost 3 |
| » Starters: Connie Marrero vs Tom Brewer | Fifth | 29½ out |
| » Defeated Red Sox (46-63), 5-4 | Fenway Park (1-4) | 47-62 | |
| » Starters: Johnny Schmitz vs Tex Clevenger | Fifth | 29½ out |
| Thursday, August 12 |
| » Defeated Red Sox (46-64), 9-5 | Fenway Park (2-4) | 48-62 | Won 2 |
| » Starters: Chuck Stobbs vs Willard Nixon | Fifth | 30 out |
| » Lost to Red Sox (47-64), 5-0 | Fenway Park (2-5) | 48-63 | |
| » Starters: Mickey McDermott vs Frank Sullivan | Fifth | 30 out |
| Friday, August 13 |
| » Lost to Athletics (38-75), 3-2 | Griffith Stadium (26-27) | 48-64 | Lost 2 |
| » Starters: Marion Fricano vs Dean Stone | Fifth | 31 out |
| Saturday, August 14 |
| » Lost to Athletics (39-75), 6-4 | Griffith Stadium (26-28) | 48-65 | Lost 3 |
| » Starters: Charlie Bishop vs Bob Porterfield | Fifth | 32 out |
| Sunday, August 15 |
| » Defeated Athletics (39-76), 4-1 | Griffith Stadium (27-28) | 49-65 | |
| » Starters: Johnny Gray vs Johnny Schmitz | Fifth | 32½ out |
| Tuesday, August 17 |
| » Lost to Red Sox (48-67), 4-3 | Griffith Stadium (27-29) | 49-66 | |
| » Starters: Frank Sullivan vs Chuck Stobbs | Fifth | 33½ out |
| Wednesday, August 18 |
| » Lost to Red Sox (49-67), 9-8 | Griffith Stadium (27-30) | 49-67 | Lost 2 |
| » Starters: Leo Kiely vs Mickey McDermott | Fifth | 34½ out |
| Thursday, August 19 |
| » Lost to Red Sox (50-67), 11-6 | Griffith Stadium (27-31) | 49-68 | Lost 3 |
| » Starters: Mel Parnell vs Dean Stone | Sixth | 35 out |
| Sunday, August 22 |
| » Lost to Athletics (40-79), 3-2 | Shibe Park (3-5) | 49-69 | Lost 4 |
| » Starters: Johnny Schmitz vs Charlie Bishop | Sixth | 37 out |
| » Tied Athletics, 4-4 | Shibe Park (3-5) | 49-69 | |
| » Starters: Bob Porterfield vs Arnie Portocarrero | Sixth | 37 out |
| Monday, August 23 |
| » Defeated Athletics (40-80), 8-5 | Shibe Park (4-5) | 50-69 | |
| » Starters: Chuck Stobbs vs Marion Fricano | Sixth | 36 out |
| » Defeated Athletics (40-81), 10-3 | Shibe Park (5-5) | 51-69 | Won 2 |
| » Starters: Gus Keriazakos vs Alex Kellner | Sixth | 36 out |
| Tuesday, August 24 |
| » Lost to White Sox (81-45), 4-0 | Griffith Stadium (27-32) | 51-70 | |
| » Starters: Jack Harshman vs Dean Stone | Sixth | 36 out |
| Wednesday, August 25 |
| » Lost to White Sox (82-45), 7-2 | Griffith Stadium (27-33) | 51-71 | Lost 2 |
| » Starters: Billy Pierce vs Bunky Stewart | Sixth | 37 out |
| Thursday, August 26 |
| » Lost to Indians (90-35), 2-1 | Griffith Stadium (27-34) | 51-72 | Lost 3 |
| » Starters: Early Wynn vs Mickey McDermott | Sixth | 38 out |
| Friday, August 27 |
| » Defeated Indians (90-36), 3-2 | Griffith Stadium (28-34) | 52-72 | |
| » Starters: Bob Feller vs Johnny Schmitz | Sixth | 37 out |
| Saturday, August 28 |
| » Lost to Indians (91-36), 5-2 | Griffith Stadium (28-35) | 52-73 | |
| » Starters: Mike Garcia vs Chuck Stobbs | Sixth | 38 out |
| Sunday, August 29 |
| » Lost to Orioles (41-88), 8-4 | Griffith Stadium (28-36) | 52-74 | Lost 2 |
| » Starters: Bob Kuzava vs Bob Porterfield | Sixth | 40 out |
| » Lost to Orioles (42-88), 5-0 | Griffith Stadium (28-37) | 52-75 | Lost 3 |
| » Starters: Joe Coleman vs Gus Keriazakos | Sixth | 40 out |
| Monday, August 30 |
| » Lost to Orioles (43-88), 3-1 | Griffith Stadium (28-38) | 52-76 | Lost 4 |
| » Starters: Bob Turley vs Dean Stone | Sixth | 41 out |
| Tuesday, August 31 |
| » Defeated Tigers (57-73), 5-3 | Griffith Stadium (29-38) | 53-76 | |
| » Starters: George Zuverink vs Mickey McDermott | Sixth | 41 out |
| Wednesday, September 1 |
| » Defeated Tigers (57-74), 4-0 | Griffith Stadium (30-38) | 54-76 | Won 2 |
| » Starters: Al Aber vs Johnny Schmitz | Sixth | 40 out |
| Thursday, September 2 |
| » Defeated Tigers (57-75), 16-6 | Griffith Stadium (31-38) | 55-76 | Won 3 |
| » Starters: Ned Garver vs Bob Porterfield | Sixth | 39 out |
| Friday, September 3 |
| » Lost to Yankees (92-41), 9-2 | Griffith Stadium (31-39) | 55-77 | |
| » Starters: Harry Byrd vs Chuck Stobbs | Sixth | 40 out |
| Saturday, September 4 |
| » Defeated Yankees (92-42), 5-2 | Griffith Stadium (32-39) | 56-77 | |
| » Starters: Tom Morgan vs Dean Stone | Sixth | 39 out |
| Sunday, September 5 |
| » Defeated Yankees (92-43), 5-4 | Griffith Stadium (33-39) | 57-77 | Won 2 |
| » Starters: Ralph Branca vs Mickey McDermott | Sixth | 39 out |
| » Major-league debuts: Woodie Held (Yankees) |
| Monday, September 6 |
| » Defeated Athletics (45-91), 8-1 | Griffith Stadium (34-39) | 58-77 | Won 3 |
| » Starters: Arnie Portocarrero vs Johnny Schmitz | Sixth | 39 out |
| » Lost to Athletics (46-91), 3-2 | Griffith Stadium (34-40) | 58-78 | |
| » Starters: Charlie Bishop vs Gus Keriazakos | Sixth | 39 out |
| Tuesday, September 7 |
| » Defeated Athletics (46-92), 5-4 | Griffith Stadium (35-40) | 59-78 | |
| » Starters: Al Sima vs Connie Marrero | Sixth | 38½ out |
| Wednesday, September 8 |
| » Lost to White Sox (88-52), 2-1 | Comiskey Park I (3-7) | 59-79 | |
| » Starters: Bob Porterfield vs Morrie Martin | Sixth | 39½ out |
| Thursday, September 9 |
| » Defeated White Sox (88-53), 2-0 | Comiskey Park I (4-7) | 60-79 | |
| » Starters: Chuck Stobbs vs Harry Dorish | Sixth | 39½ out |
| Friday, September 10 |
| » Lost to Orioles (47-94), 4-3 | Memorial Stadium (6-4) | 60-80 | |
| » Starters: Mickey McDermott vs Lou Kretlow | Sixth | 40½ out |
| Saturday, September 11 |
| » Defeated Orioles (47-95), 3-0 | Memorial Stadium (7-4) | 61-80 | |
| » Starters: Dean Stone vs Don Larsen | Sixth | 40½ out |
| Sunday, September 12 |
| » Lost to Tigers (63-79), 5-0 | Tiger Stadium (5-5) | 61-81 | |
| » Starters: Johnny Schmitz vs Steve Gromek | Sixth | 42½ out |
| » Lost to Tigers (64-79), 8-3 | Tiger Stadium (5-6) | 61-82 | Lost 2 |
| » Starters: Bob Porterfield vs Ted Gray | Sixth | 42½ out |
| Tuesday, September 14 |
| » Lost to Indians (105-40), 4-2 | Cleveland Stadium (0-11) | 61-83 | Lost 3 |
| » Starters: Chuck Stobbs vs Mike Garcia | Sixth | 43½ out |
| Friday, September 17 |
| » Defeated Red Sox (63-82), 8-0 | Griffith Stadium (36-40) | 62-83 | |
| » Starters: Frank Sullivan vs Dean Stone | Sixth | 43½ out |
| » Major-league debuts: Guy Morton (Red Sox) |
| Saturday, September 18 |
| » Defeated Red Sox (63-83), 8-7 | Griffith Stadium (37-40) | 63-83 | Won 2 |
| » Starters: Willard Nixon vs Mickey McDermott | Fifth | 43½ out |
| Sunday, September 19 |
| » Lost to Red Sox (64-83), 6-2 | Griffith Stadium (37-41) | 63-84 | |
| » Starters: Mel Parnell vs Bob Porterfield | Sixth | 44½ out |
| Monday, September 20 |
| » Defeated Yankees (100-49), 3-2 | Yankee Stadium (4-5) | 64-84 | |
| » Starters: Johnny Schmitz vs Whitey Ford | Sixth | 44½ out |
| Tuesday, September 21 |
| » Lost to Yankees (101-49), 3-1 | Yankee Stadium (4-6) | 64-85 | |
| » Starters: Dean Stone vs Bob Grim | Sixth | 44½ out |
| Wednesday, September 22 |
| » Lost to Yankees (102-49), 3-0 | Yankee Stadium (4-7) | 64-86 | Lost 2 |
| » Starters: Mickey McDermott vs Tommy Byrne | Sixth | 45½ out |
| Friday, September 24 |
| » Defeated Red Sox (67-84), 1-0 | Fenway Park (3-5) | 65-86 | |
| » Starters: Chuck Stobbs vs Hal Brown | Fifth | 44 out |
| » Defeated Red Sox (67-85), 6-4 | Fenway Park (4-5) | 66-86 | Won 2 |
| » Starters: Bob Porterfield vs Mel Parnell | Fifth | 44 out |
| Saturday, September 25 |
| » Lost to Red Sox (68-85), 7-6 | Fenway Park (4-6) | 66-87 | |
| » Starters: Johnny Schmitz vs Willard Nixon | Sixth | 45 out |
| Sunday, September 26 |
| » Lost to Red Sox (69-85), 11-2 | Fenway Park (4-7) | 66-88 | Lost 2 |
| » Starters: Dean Stone vs Frank Sullivan | Sixth | 45 out |
| Friday, October 22 |
| Former Senator Earl Whitehill dies in Omaha, NE at the age of 55. |
| Saturday, December 11 |
| Former Senator Henry Courtney dies in Lyme, CT at the age of 57. |
Game information provided by Retrosheet (www.retrosheet.org) |
