| Saturday, January 16 |
| Future Red Sox Dave Stapleton is born in Fairhope, AL. |
| Tuesday, January 19 |
| Future Red Sox Rich Gale is born in Littleton, NH. |
| Saturday, January 23 |
| Future Red Sox Garry Hancock is born in Tampa, FL. |
| Tuesday, February 2 |
| Future Red Sox John Tudor is born in Schenectady, NY. |
| Tuesday, April 13 |
| » Lost to Athletics (1-0), 6-4 | Shibe Park (0-1) | 0-1 | |
| » Starters: Mel Parnell vs Bobby Shantz | Second | 1 out |
| » Major-league debuts: Billy Shantz and Bill Upton (Athletics) Harry Agganis (Red Sox) |
| Thursday, April 15 |
| » Defeated Senators (1-2), 6-1 | Fenway Park (1-0) | 1-1 | |
| » Starters: Bob Porterfield vs Bill Henry | Second | ½ out |
| Sunday, April 18 |
| » Lost to Athletics (2-1), 6-4 | Fenway Park (1-1) | 1-2 | |
| » Starters: Bob Trice vs Tom Brewer | Second | 1½ out |
| » Defeated Athletics (2-2), 4-3 | Fenway Park (2-1) | 2-2 | |
| » Starters: Arnie Portocarrero vs Sid Hudson | Second | 1½ out |
| » Major-league debuts: Tom Brewer and Tex Clevenger (Red Sox) |
| Monday, April 19 |
| » Defeated Yankees (2-3), 2-1 | Fenway Park (3-1) | 3-2 | Won 2 |
| » Starters: Harry Byrd vs Willard Nixon | Third | 1 out |
| » Lost to Yankees (3-3), 5-0 | Fenway Park (3-2) | 3-3 | |
| » Starters: Jim McDonald vs Mel Parnell | Third | 1 out |
| Tuesday, April 20 |
| Future Red Sox Mike O'Berry is born in Birmingham, AL. |
| Wednesday, April 21 |
| » Lost to Yankees (4-3), 5-1 | Yankee Stadium (0-1) | 3-4 | Lost 2 |
| » Starters: Leo Kiely vs Ed Lopat | Third | 1 out |
| Friday, April 23 |
| » Lost to Senators (5-3), 7-6 | Griffith Stadium (0-1) | 3-5 | Lost 3 |
| » Starters: Bill Henry vs Spec Shea | Fifth | 2 out |
| Saturday, April 24 |
| » Defeated Senators (5-4), 6-1 | Griffith Stadium (1-1) | 4-5 | |
| » Starters: Mel Parnell vs Mickey McDermott | Fourth | 2 out |
| Sunday, April 25 |
| » Lost to Senators (6-4), 5-1 | Griffith Stadium (1-2) | 4-6 | |
| » Starters: Leo Kiely vs Chuck Stobbs | Fourth | 2½ out |
| Thursday, April 29 |
| » Lost to Indians (5-6), 6-3 | Fenway Park (3-3) | 4-7 | Lost 2 |
| » Starters: Mike Garcia vs Willard Nixon | Eighth | 3 out |
| Friday, April 30 |
| » Lost to White Sox (9-5), 5-0 | Fenway Park (3-4) | 4-8 | Lost 3 |
| » Starters: Bob Keegan vs Sid Hudson | Seventh | 4 out |
| Saturday, May 1 |
| » Lost to White Sox (10-5), 3-0 | Fenway Park (3-5) | 4-9 | Lost 4 |
| » Starters: Virgil Trucks vs Bill Henry | Eighth | 5 out |
| Friday, May 7 |
| » Defeated Senators (7-12), 7-6 | Fenway Park (4-5) | 5-9 | |
| » Starters: Spec Shea vs Tex Clevenger | Seventh | 5½ out |
| Tuesday, May 11 |
| » Lost to White Sox (15-9), 2-1 | Comiskey Park I (0-1) | 5-10 | |
| » Starters: Leo Kiely vs Bob Keegan | Seventh | 5 out |
| Wednesday, May 12 |
| » Lost to White Sox (16-9), 1-0 | Comiskey Park I (0-2) | 5-11 | Lost 2 |
| » Starters: Tom Brewer vs Don Johnson | Seventh | 6 out |
| Thursday, May 13 |
| » Defeated Orioles (8-13), 9-1 | Memorial Stadium (1-0) | 6-11 | |
| » Starters: Bill Henry vs Duane Pillette | Seventh | 5 out |
| Friday, May 14 |
| » Lost to Orioles (9-13), 7-2 | Memorial Stadium (1-1) | 6-12 | |
| » Starters: Willard Nixon vs Bob Turley | Seventh | 6½ out |
| Saturday, May 15 |
| » Lost to Orioles (10-13), 2-1 | Memorial Stadium (1-2) | 6-13 | Lost 2 |
| » Starters: Tex Clevenger vs Joe Coleman | Seventh | 7½ out |
| Sunday, May 16 |
| » Lost to Tigers (13-9), 7-6 | Tiger Stadium (0-1) | 6-14 | Lost 3 |
| » Starters: Hal Brown vs Ted Gray | Eighth | 8½ out |
| » Lost to Tigers (14-9), 9-8 | Tiger Stadium (0-2) | 6-15 | Lost 4 |
| » Starters: Leo Kiely vs Ralph Branca | Eighth | 8½ out |
| Monday, May 17 |
| » Defeated Tigers (14-10), 4-3 | Tiger Stadium (1-2) | 7-15 | |
| » Starters: Tom Brewer vs Ned Garver | Eighth | 8 out |
| Tuesday, May 18 |
| » Lost to Indians (19-10), 6-3 | Cleveland Stadium (0-1) | 7-16 | |
| » Starters: Bill Henry vs Art Houtteman | Eighth | 9 out |
| Wednesday, May 19 |
| » Lost to Indians (20-10), 5-3 | Cleveland Stadium (0-2) | 7-17 | Lost 2 |
| » Starters: Willard Nixon vs Bob Lemon | Eighth | 10 out |
| Future Red Sox Rick Cerone is born in Newark, NJ. |
| Friday, May 21 |
| » Defeated Yankees (19-12), 6-3 | Yankee Stadium (1-1) | 8-17 | |
| » Starters: Frank Sullivan vs Whitey Ford | Eighth | 10 out |
| Saturday, May 22 |
| » Lost to Yankees (20-12), 7-0 | Yankee Stadium (1-2) | 8-18 | |
| » Starters: Tex Clevenger vs Allie Reynolds | Eighth | 11 out |
| Sunday, May 23 |
| » Defeated Yankees (20-13), 10-9 | Yankee Stadium (2-2) | 9-18 | |
| » Starters: Bill Henry vs Tom Morgan | Seventh | 11½ out |
| Tuesday, May 25 |
| » Defeated Athletics (11-23), 3-2 | Shibe Park (1-1) | 10-18 | Won 2 |
| » Starters: Willard Nixon vs Marion Fricano | Sixth | 10½ out |
| Wednesday, May 26 |
| » Lost to Athletics (12-23), 6-5 | Shibe Park (1-2) | 10-19 | |
| » Starters: Leo Kiely vs Art Ditmar | Seventh | 10½ out |
| Friday, May 28 |
| » Lost to Yankees (23-15), 10-9 | Fenway Park (4-6) | 10-20 | Lost 2 |
| » Starters: Allie Reynolds vs Frank Sullivan | Sixth | 11½ out |
| Saturday, May 29 |
| » Lost to Yankees (24-15), 10-2 | Fenway Park (4-7) | 10-21 | Lost 3 |
| » Starters: Harry Byrd vs Sid Hudson | Eighth | 12½ out |
| Sunday, May 30 |
| » Defeated Yankees (24-16), 3-1 | Fenway Park (5-7) | 11-21 | |
| » Starters: Jim McDonald vs Willard Nixon | Seventh | 12½ out |
| Monday, May 31 |
| » Defeated Athletics (14-26), 20-10 | Fenway Park (6-7) | 12-21 | Won 2 |
| » Starters: Art Ditmar vs Tom Brewer | Sixth | 11½ out |
| » Defeated Athletics (14-27), 9-0 | Fenway Park (7-7) | 13-21 | Won 3 |
| » Starters: Ozzie VanBrabant vs Bill Henry | Sixth | 11½ out |
| Tuesday, June 1 |
| » Lost to Athletics (15-27), 16-6 | Fenway Park (7-8) | 13-22 | |
| » Starters: Bob Trice vs Tex Clevenger | Sixth | 12 out |
| Wednesday, June 2 |
| » Defeated White Sox (28-16), 5-2 | Fenway Park (8-8) | 14-22 | |
| » Starters: Sandy Consuegra vs Frank Sullivan | Sixth | 12 out |
| Thursday, June 3 |
| » Lost to White Sox (29-16), 9-6 | Fenway Park (8-9) | 14-23 | |
| » Starters: Virgil Trucks vs Hal Brown | Sixth | 12 out |
| Friday, June 4 |
| » Lost to White Sox (30-16), 7-3 | Fenway Park (8-10) | 14-24 | Lost 2 |
| » Starters: Bob Keegan vs Willard Nixon | Seventh | 12 out |
| Saturday, June 5 |
| » Lost to Tigers (23-19), 6-0 | Fenway Park (8-11) | 14-25 | Lost 3 |
| » Starters: George Zuverink vs Bill Henry | Sixth | 12½ out |
| » Defeated Tigers (23-20), 5-4 | Fenway Park (9-11) | 15-25 | |
| » Starters: Dick Marlowe vs Leo Kiely | Sixth | 12½ out |
| Sunday, June 6 |
| » Defeated Tigers (23-21), 7-4 | Fenway Park (10-11) | 16-25 | Won 2 |
| » Starters: Ralph Branca vs Willard Nixon | Sixth | 13 out |
| Monday, June 7 |
| » Defeated Tigers (23-22), 3-2 | Fenway Park (11-11) | 17-25 | Won 3 |
| » Starters: Steve Gromek vs Frank Sullivan | Fifth | 12 out |
| » Defeated Tigers (23-23), 5-4 | Fenway Park (12-11) | 18-25 | Won 4 |
| » Starters: Ned Garver vs Tom Brewer | Fifth | 12 out |
| Tuesday, June 8 |
| » Lost to Orioles (18-31), 7-4 | Fenway Park (12-12) | 18-26 | |
| » Starters: Bob Chakales vs Tex Clevenger | Sixth | 13 out |
| Wednesday, June 9 |
| » Defeated Orioles (18-32), 7-6 | Fenway Park (13-12) | 19-26 | |
| » Starters: Bob Turley vs Bill Henry | Fifth | 13 out |
| Thursday, June 10 |
| » Lost to Orioles (19-32), 5-1 | Fenway Park (13-13) | 19-27 | |
| » Starters: Joe Coleman vs Leo Kiely | Sixth | 14 out |
| » Lost to Orioles (20-32), 9-0 | Fenway Park (13-14) | 19-28 | Lost 2 |
| » Starters: Duane Pillette vs Tom Herrin | Sixth | 14 out |
| Friday, June 11 |
| » Lost to Indians (34-17), 6-2 | Fenway Park (13-15) | 19-29 | Lost 3 |
| » Starters: Art Houtteman vs Willard Nixon | Sixth | 14 out |
| Saturday, June 12 |
| » Lost to Indians (35-17), 4-3 | Fenway Park (13-16) | 19-30 | Lost 4 |
| » Starters: Bob Feller vs Tom Brewer | Seventh | 14½ out |
| Sunday, June 13 |
| » Lost to Indians (36-17), 4-1 | Fenway Park (13-17) | 19-31 | Lost 5 |
| » Starters: Early Wynn vs Frank Sullivan | Eighth | 16½ out |
| » Lost to Indians (37-17), 8-1 | Fenway Park (13-18) | 19-32 | Lost 6 |
| » Starters: Mike Garcia vs Tex Clevenger | Eighth | 16½ out |
| Monday, June 14 |
| » Lost to Indians (38-17), 13-5 | Fenway Park (13-19) | 19-33 | Lost 7 |
| » Starters: Bob Lemon vs Bill Henry | Eighth | 17½ out |
| Tuesday, June 15 |
| » Lost to Tigers (26-29), 4-1 | Tiger Stadium (1-3) | 19-34 | Lost 8 |
| » Starters: Leo Kiely vs Steve Gromek | Eighth | 18½ out |
| Wednesday, June 16 |
| » Defeated Tigers (26-30), 3-2 | Tiger Stadium (2-3) | 20-34 | |
| » Starters: Willard Nixon vs Ned Garver | Eighth | 18½ out |
| Thursday, June 17 |
| » Lost to Tigers (27-30), 2-1 | Tiger Stadium (2-4) | 20-35 | |
| » Starters: Tom Brewer vs George Zuverink | Eighth | 19½ out |
| Friday, June 18 |
| » Lost to Indians (42-17), 2-0 | Cleveland Stadium (0-3) | 20-36 | Lost 2 |
| » Starters: Frank Sullivan vs Mike Garcia | Eighth | 20½ out |
| Saturday, June 19 |
| » Defeated Indians (42-18), 6-3 | Cleveland Stadium (1-3) | 21-36 | |
| » Starters: Ellis Kinder vs Bob Lemon | Seventh | 19½ out |
| Sunday, June 20 |
| » Lost to Indians (43-18), 3-1 | Cleveland Stadium (1-4) | 21-37 | |
| » Starters: Leo Kiely vs Bob Feller | Seventh | 21½ out |
| » Lost to Indians (44-18), 9-2 | Cleveland Stadium (1-5) | 21-38 | Lost 2 |
| » Starters: Willard Nixon vs Art Houtteman | Seventh | 21½ out |
| Tuesday, June 22 |
| » Defeated Orioles (22-42), 3-1 | Memorial Stadium (2-2) | 22-38 | |
| » Starters: Tom Brewer vs Bob Turley | Seventh | 20½ out |
| Wednesday, June 23 |
| » Lost to Orioles (23-42), 8-7 | Memorial Stadium (2-3) | 22-39 | |
| » Starters: Frank Sullivan vs Joe Coleman | Seventh | 21½ out |
| Friday, June 25 |
| » Lost to White Sox (44-22), 6-4 | Comiskey Park I (0-3) | 22-40 | Lost 2 |
| » Starters: Willard Nixon vs Bob Keegan | Eighth | 21 out |
| Saturday, June 26 |
| » Defeated White Sox (44-23), 3-1 | Comiskey Park I (1-3) | 23-40 | |
| » Starters: Frank Sullivan vs Don Johnson | Eighth | 20 out |
| Sunday, June 27 |
| » Defeated White Sox (44-24), 2-1 | Comiskey Park I (2-3) | 24-40 | Won 2 |
| » Starters: Tom Brewer vs Virgil Trucks | Eighth | 20½ out |
| » Lost to White Sox (45-24), 9-1 | Comiskey Park I (2-4) | 24-41 | |
| » Starters: Bill Henry vs Jack Harshman | Eighth | 20½ out |
| Tuesday, June 29 |
| » Lost to Yankees (45-26), 14-5 | Fenway Park (13-20) | 24-42 | Lost 2 |
| » Starters: Harry Byrd vs Hal Brown | Eighth | 21½ out |
| Wednesday, June 30 |
| » Defeated Yankees (45-27), 6-1 | Fenway Park (14-20) | 25-42 | |
| » Starters: Tom Morgan vs Willard Nixon | Eighth | 21½ out |
| Thursday, July 1 |
| » Lost to Yankees (46-27), 8-7 | Fenway Park (14-21) | 25-43 | |
| » Starters: Allie Reynolds vs Frank Sullivan | Eighth | 22 out |
| Friday, July 2 |
| » Defeated Athletics (28-42), 8-4 | Fenway Park (15-21) | 26-43 | |
| » Starters: Bob Trice vs Tom Brewer | Eighth | 22½ out |
| Saturday, July 3 |
| » Lost to Athletics (29-42), 7-3 | Fenway Park (15-22) | 26-44 | |
| » Starters: Alex Kellner vs Tex Clevenger | Eighth | 23½ out |
| Sunday, July 4 |
| » Defeated Athletics (29-43), 8-0 | Fenway Park (16-22) | 27-44 | |
| » Starters: Al Sima vs Leo Kiely | Eighth | 23½ out |
| Monday, July 5 |
| » Defeated Senators (30-44), 14-0 | Griffith Stadium (2-2) | 28-44 | Won 2 |
| » Starters: Willard Nixon vs Connie Marrero | Eighth | 23½ out |
| » Lost to Senators (31-44), 7-1 | Griffith Stadium (2-3) | 28-45 | |
| » Starters: Bill Henry vs Chuck Stobbs | Eighth | 23½ out |
| Tuesday, July 6 |
| » Lost to Yankees (52-28), 4-1 | Yankee Stadium (2-3) | 28-46 | Lost 2 |
| » Starters: Frank Sullivan vs Whitey Ford | Eighth | 24½ out |
| Wednesday, July 7 |
| » Lost to Yankees (53-28), 17-9 | Yankee Stadium (2-4) | 28-47 | Lost 3 |
| » Starters: Tom Brewer vs Allie Reynolds | Eighth | 25½ out |
| Friday, July 9 |
| » Lost to Athletics (30-46), 9-3 | Shibe Park (1-3) | 28-48 | Lost 4 |
| » Starters: Leo Kiely vs Alex Kellner | Eighth | 26 out |
| Saturday, July 10 |
| » Defeated Athletics (30-47), 5-3 | Shibe Park (2-3) | 29-48 | |
| » Starters: Willard Nixon vs Arnie Portocarrero | Eighth | 25 out |
| Future Red Sox Andre Dawson is born in Miami, FL. |
| Sunday, July 11 |
| » Defeated Athletics (30-48), 18-0 | Shibe Park (3-3) | 30-48 | Won 2 |
| » Starters: Frank Sullivan vs Bob Trice | Sixth | 23 out |
| » Defeated Athletics (30-49), 11-1 | Shibe Park (4-3) | 31-48 | Won 3 |
| » Starters: Tom Brewer vs Marion Fricano | Sixth | 23 out |
| Wednesday, July 14 |
| Future Red Sox Chuck Rainey is born in San Diego, CA. |
| Thursday, July 15 |
| » Defeated Tigers (35-45), 3-1 | Fenway Park (17-22) | 32-48 | Won 4 |
| » Starters: Steve Gromek vs Willard Nixon | Sixth | 23½ out |
| » Lost to Tigers (36-45), 4-2 | Fenway Park (17-23) | 32-49 | |
| » Starters: George Zuverink vs Leo Kiely | Sixth | 23½ out |
| Friday, July 16 |
| » Defeated Tigers (36-46), 3-0 | Fenway Park (18-23) | 33-49 | |
| » Starters: Ned Garver vs Frank Sullivan | Sixth | 23½ out |
| Saturday, July 17 |
| » Defeated Tigers (36-47), 7-6 | Fenway Park (19-23) | 34-49 | Won 2 |
| » Starters: Ray Herbert vs Tom Brewer | Sixth | 23½ out |
| Sunday, July 18 |
| » Defeated Orioles (31-55), 4-0 | Fenway Park (20-23) | 35-49 | Won 3 |
| » Starters: Bob Turley vs Russ Kemmerer | Sixth | 23½ out |
| » Lost to Orioles (32-55), 4-1 | Fenway Park (20-24) | 35-50 | |
| » Starters: Duane Pillette vs Bill Henry | Sixth | 23½ out |
| Monday, July 19 |
| » Defeated Orioles (32-56), 9-7 | Fenway Park (21-24) | 36-50 | |
| » Starters: Bob Chakales vs Sid Hudson | Fifth | 23 out |
| » Defeated Orioles (32-57), 8-5 | Fenway Park (22-24) | 37-50 | Won 2 |
| » Starters: Don Larsen vs Leo Kiely | Fifth | 23 out |
| Tuesday, July 20 |
| » Tied Indians, 5-5 | Fenway Park (22-24) | 37-50 | |
| » Starters: Mike Garcia vs Willard Nixon | Fifth | 23 out |
| Wednesday, July 21 |
| » Tied Indians, 7-7 | Fenway Park (22-24) | 37-50 | |
| » Starters: Art Houtteman vs Tom Brewer | Fifth | 23 out |
| Thursday, July 22 |
| » Lost to Indians (62-28), 6-3 | Fenway Park (22-25) | 37-51 | |
| » Starters: Bob Feller vs Frank Sullivan | Sixth | 25 out |
| » Lost to Indians (63-28), 5-2 | Fenway Park (22-26) | 37-52 | Lost 2 |
| » Starters: Bob Lemon vs Hal Brown | Sixth | 25 out |
| Friday, July 23 |
| » Lost to White Sox (59-36), 7-1 | Fenway Park (22-27) | 37-53 | Lost 3 |
| » Starters: Harry Dorish vs Russ Kemmerer | Sixth | 26 out |
| Saturday, July 24 |
| » Defeated White Sox (59-37), 5-2 | Fenway Park (23-27) | 38-53 | |
| » Starters: Bob Keegan vs Leo Kiely | Sixth | 26 out |
| Sunday, July 25 |
| » Lost to White Sox (60-37), 5-2 | Fenway Park (23-28) | 38-54 | |
| » Starters: Jack Harshman vs Willard Nixon | Sixth | 26½ out |
| » Lost to White Sox (61-37), 4-2 | Fenway Park (23-29) | 38-55 | Lost 2 |
| » Starters: Don Johnson vs Tom Brewer | Sixth | 26½ out |
| Tuesday, July 27 |
| » Lost to Indians (66-29), 6-3 | Cleveland Stadium (1-6) | 38-56 | Lost 3 |
| » Starters: Frank Sullivan vs Bob Lemon | Sixth | 27½ out |
| Wednesday, July 28 |
| » Lost to Indians (67-29), 2-1 | Cleveland Stadium (1-7) | 38-57 | Lost 4 |
| » Starters: Russ Kemmerer vs Early Wynn | Sixth | 28½ out |
| Thursday, July 29 |
| » Defeated Indians (67-30), 10-2 | Cleveland Stadium (2-7) | 39-57 | |
| » Starters: Leo Kiely vs Bob Feller | Sixth | 27½ out |
| Friday, July 30 |
| » Lost to Tigers (45-54), 5-0 | Tiger Stadium (2-5) | 39-58 | |
| » Starters: Willard Nixon vs Ned Garver | Sixth | 28½ out |
| » Major-league debuts: Tom Hurd (Red Sox) |
| Saturday, July 31 |
| » Defeated Tigers (45-55), 4-0 | Tiger Stadium (3-5) | 40-58 | |
| » Starters: Tom Brewer vs Steve Gromek | Sixth | 28½ out |
| Sunday, August 1 |
| » Defeated Tigers (45-56), 10-8 | Tiger Stadium (4-5) | 41-58 | Won 2 |
| » Starters: Mel Parnell vs Al Aber | Sixth | 29 out |
| Monday, August 2 |
| Future Red Sox Roger LaFrancois is born in Norwich, CT. |
| Tuesday, August 3 |
| » Lost to White Sox (67-39), 6-2 | Comiskey Park I (2-5) | 41-59 | |
| » Starters: Frank Sullivan vs Jack Harshman | Sixth | 29 out |
| Wednesday, August 4 |
| » Lost to White Sox (68-39), 6-5 | Comiskey Park I (2-6) | 41-60 | Lost 2 |
| » Starters: Russ Kemmerer vs Billy Pierce | Sixth | 30 out |
| Thursday, August 5 |
| » Lost to White Sox (69-39), 5-1 | Comiskey Park I (2-7) | 41-61 | Lost 3 |
| » Starters: Tom Brewer vs Bob Keegan | Sixth | 30 out |
| Friday, August 6 |
| » Defeated Orioles (37-70), 3-1 | Memorial Stadium (3-3) | 42-61 | |
| » Starters: Willard Nixon vs Joe Coleman | Sixth | 30 out |
| Saturday, August 7 |
| » Lost to Orioles (38-70), 2-1 | Memorial Stadium (3-4) | 42-62 | |
| » Starters: Mel Parnell vs Bob Turley | Sixth | 31 out |
| Sunday, August 8 |
| » Defeated Orioles (38-71), 4-2 | Memorial Stadium (4-4) | 43-62 | |
| » Starters: Russ Kemmerer vs Duane Pillette | Sixth | 31 out |
| » Defeated Orioles (38-72), 4-1 | Memorial Stadium (5-4) | 44-62 | Won 2 |
| » Starters: Frank Sullivan vs Don Larsen | Sixth | 31 out |
| Tuesday, August 10 |
| » Defeated Senators (46-61), 4-0 | Fenway Park (24-29) | 45-62 | Won 3 |
| » Starters: Bob Porterfield vs Mel Parnell | Sixth | 30 out |
| Wednesday, August 11 |
| » Defeated Senators (46-62), 10-1 | Fenway Park (25-29) | 46-62 | Won 4 |
| » Starters: Connie Marrero vs Tom Brewer | Sixth | 30½ out |
| » Lost to Senators (47-62), 5-4 | Fenway Park (25-30) | 46-63 | |
| » Starters: Johnny Schmitz vs Tex Clevenger | Sixth | 30½ out |
| Thursday, August 12 |
| » Lost to Senators (48-62), 9-5 | Fenway Park (25-31) | 46-64 | Lost 2 |
| » Starters: Chuck Stobbs vs Willard Nixon | Sixth | 31 out |
| » Defeated Senators (48-63), 5-0 | Fenway Park (26-31) | 47-64 | |
| » Starters: Mickey McDermott vs Frank Sullivan | Sixth | 31 out |
| Friday, August 13 |
| » Lost to Yankees (78-37), 8-2 | Yankee Stadium (2-5) | 47-65 | |
| » Starters: Leo Kiely vs Whitey Ford | Sixth | 32 out |
| Saturday, August 14 |
| » Lost to Yankees (79-37), 3-1 | Yankee Stadium (2-6) | 47-66 | Lost 2 |
| » Starters: Russ Kemmerer vs Ralph Branca | Sixth | 33 out |
| Sunday, August 15 |
| » Lost to Yankees (80-37), 14-9 | Yankee Stadium (2-7) | 47-67 | Lost 3 |
| » Starters: Tom Brewer vs Bob Grim | Sixth | 34½ out |
| Tuesday, August 17 |
| » Defeated Senators (49-66), 4-3 | Griffith Stadium (3-3) | 48-67 | |
| » Starters: Frank Sullivan vs Chuck Stobbs | Sixth | 34½ out |
| Wednesday, August 18 |
| » Defeated Senators (49-67), 9-8 | Griffith Stadium (4-3) | 49-67 | Won 2 |
| » Starters: Leo Kiely vs Mickey McDermott | Fifth | 34½ out |
| Thursday, August 19 |
| » Defeated Senators (49-68), 11-6 | Griffith Stadium (5-3) | 50-67 | Won 3 |
| » Starters: Mel Parnell vs Dean Stone | Fifth | 34 out |
| Friday, August 20 |
| » Defeated Yankees (83-38), 4-3 | Fenway Park (27-31) | 51-67 | Won 4 |
| » Starters: Bob Grim vs Willard Nixon | Fifth | 34 out |
| Saturday, August 21 |
| » Defeated Yankees (83-39), 10-9 | Fenway Park (28-31) | 52-67 | Won 5 |
| » Starters: Tom Morgan vs Ellis Kinder | Fifth | 34 out |
| Sunday, August 22 |
| » Defeated Yankees (83-40), 8-2 | Fenway Park (29-31) | 53-67 | Won 6 |
| » Starters: Harry Byrd vs Frank Sullivan | Fifth | 34 out |
| Tuesday, August 24 |
| » Lost to Tigers (55-68), 8-7 | Fenway Park (29-32) | 53-68 | |
| » Starters: Ned Garver vs Mel Parnell | Fifth | 34 out |
| Wednesday, August 25 |
| » Defeated Tigers (55-69), 5-3 | Fenway Park (30-32) | 54-68 | |
| » Starters: Steve Gromek vs Willard Nixon | Fifth | 34 out |
| Thursday, August 26 |
| » Lost to Orioles (40-86), 5-3 | Fenway Park (30-33) | 54-69 | |
| » Starters: Bob Turley vs Sid Hudson | Fifth | 35 out |
| Friday, August 27 |
| » Defeated Orioles (40-87), 3-2 | Fenway Park (31-33) | 55-69 | |
| » Starters: Lou Kretlow vs Russ Kemmerer | Fourth | 34 out |
| Saturday, August 28 |
| » Defeated Orioles (40-88), 3-2 | Fenway Park (32-33) | 56-69 | Won 2 |
| » Starters: Don Larsen vs Mel Parnell | Fourth | 34 out |
| Sunday, August 29 |
| » Lost to Indians (92-36), 6-2 | Fenway Park (32-34) | 56-70 | |
| » Starters: Bob Lemon vs Tom Brewer | Fifth | 36 out |
| » Lost to Indians (93-36), 8-1 | Fenway Park (32-35) | 56-71 | Lost 2 |
| » Starters: Art Houtteman vs Frank Sullivan | Fifth | 36 out |
| Monday, August 30 |
| » Lost to Indians (94-36), 5-4 | Fenway Park (32-36) | 56-72 | Lost 3 |
| » Starters: Ray Narleski vs Willard Nixon | Fifth | 37 out |
| Wednesday, September 1 |
| » Defeated White Sox (85-48), 7-2 | Fenway Park (33-36) | 57-72 | |
| » Starters: Billy Pierce vs Russ Kemmerer | Fourth | 37 out |
| » Lost to White Sox (86-48), 6-3 | Fenway Park (33-37) | 57-73 | |
| » Starters: Harry Dorish vs Mel Parnell | Fourth | 37 out |
| Friday, September 3 |
| » Defeated Athletics (44-88), 11-1 | Shibe Park (5-3) | 58-73 | |
| » Starters: Frank Sullivan vs Arnie Portocarrero | Fourth | 36½ out |
| Saturday, September 4 |
| » Lost to Athletics (45-88), 4-3 | Shibe Park (5-4) | 58-74 | |
| » Starters: Willard Nixon vs Johnny Gray | Fifth | 36½ out |
| Sunday, September 5 |
| » Defeated Athletics (45-89), 12-5 | Shibe Park (6-4) | 59-74 | |
| » Starters: Tom Brewer vs Charlie Bishop | Fourth | 36 out |
| » Defeated Athletics (45-90), 7-3 | Shibe Park (7-4) | 60-74 | Won 2 |
| » Starters: Russ Kemmerer vs Sonny Dixon | Fourth | 36 out |
| Monday, September 6 |
| » Lost to Yankees (93-43), 6-5 | Yankee Stadium (2-8) | 60-75 | |
| » Starters: Mel Parnell vs Bob Grim | Fourth | 36 out |
| » Defeated Yankees (93-44), 8-7 | Yankee Stadium (3-8) | 61-75 | |
| » Starters: Leo Kiely vs Whitey Ford | Fourth | 36 out |
| Wednesday, September 8 |
| » Defeated Tigers (61-77), 5-2 | Tiger Stadium (5-5) | 62-75 | Won 2 |
| » Starters: Frank Sullivan vs Steve Gromek | Fourth | 36 out |
| Future Red Sox Don Aase is born in Orange, CA. |
| Thursday, September 9 |
| » Defeated Tigers (61-78), 8-0 | Tiger Stadium (6-5) | 63-75 | Won 3 |
| » Starters: Willard Nixon vs Al Aber | Fourth | 36 out |
| Friday, September 10 |
| » Lost to Indians (101-40), 4-2 | Cleveland Stadium (2-8) | 63-76 | |
| » Starters: Leo Kiely vs Mike Garcia | Fourth | 37 out |
| Saturday, September 11 |
| » Lost to Indians (102-40), 3-0 | Cleveland Stadium (2-9) | 63-77 | Lost 2 |
| » Starters: Mel Parnell vs Art Houtteman | Fourth | 38 out |
| Sunday, September 12 |
| » Lost to White Sox (90-54), 5-3 | Comiskey Park I (2-8) | 63-78 | Lost 3 |
| » Starters: Tom Brewer vs Bob Keegan | Fifth | 40 out |
| » Lost to White Sox (91-54), 7-5 | Comiskey Park I (2-9) | 63-79 | Lost 4 |
| » Starters: Frank Sullivan vs Billy Pierce | Fifth | 40 out |
| Tuesday, September 14 |
| » Lost to Orioles (49-96), 3-1 | Memorial Stadium (5-5) | 63-80 | Lost 5 |
| » Starters: Willard Nixon vs Joe Coleman | Fifth | 41 out |
| Wednesday, September 15 |
| » Lost to Orioles (50-96), 2-1 | Memorial Stadium (5-6) | 63-81 | Lost 6 |
| » Starters: Mel Parnell vs Lou Kretlow | Fifth | 41½ out |
| Friday, September 17 |
| » Lost to Senators (62-83), 8-0 | Griffith Stadium (5-4) | 63-82 | Lost 7 |
| » Starters: Frank Sullivan vs Dean Stone | Fifth | 42½ out |
| » Major-league debuts: Guy Morton (Red Sox) |
| Saturday, September 18 |
| » Lost to Senators (63-83), 8-7 | Griffith Stadium (5-5) | 63-83 | Lost 8 |
| » Starters: Willard Nixon vs Mickey McDermott | Fifth | 43½ out |
| Sunday, September 19 |
| » Defeated Senators (63-84), 6-2 | Griffith Stadium (6-5) | 64-83 | |
| » Starters: Mel Parnell vs Bob Porterfield | Fourth | 43½ out |
| Monday, September 20 |
| » Defeated Athletics (49-100), 5-2 | Fenway Park (34-37) | 65-83 | Won 2 |
| » Starters: Johnny Gray vs Tom Brewer | Fourth | 43½ out |
| Tuesday, September 21 |
| » Defeated Athletics (49-101), 4-3 | Fenway Park (35-37) | 66-83 | Won 3 |
| » Starters: Lee Wheat vs Willard Nixon | Fourth | 42 out |
| » Defeated Athletics (49-102), 4-3 | Fenway Park (36-37) | 67-83 | Won 4 |
| » Starters: Ozzie VanBrabant vs Frank Sullivan | Fourth | 42 out |
| Friday, September 24 |
| » Lost to Senators (65-86), 1-0 | Fenway Park (36-38) | 67-84 | |
| » Starters: Chuck Stobbs vs Hal Brown | Fourth | 43 out |
| » Lost to Senators (66-86), 6-4 | Fenway Park (36-39) | 67-85 | Lost 2 |
| » Starters: Bob Porterfield vs Mel Parnell | Fourth | 43 out |
| Saturday, September 25 |
| » Defeated Senators (66-87), 7-6 | Fenway Park (37-39) | 68-85 | |
| » Starters: Johnny Schmitz vs Willard Nixon | Fourth | 43 out |
| Sunday, September 26 |
| » Defeated Senators (66-88), 11-2 | Fenway Park (38-39) | 69-85 | Won 2 |
| » Starters: Dean Stone vs Frank Sullivan | Fourth | 42 out |
| Sunday, October 3 |
| Future Red Sox Dennis Eckersley is born in Oakland, CA. |
| Thursday, October 28 |
| Future Red Sox Sammy Stewart is born in Asheville, NC. |
| Wednesday, November 10 |
| Future Red Sox Bob Stanley is born in Portland, ME. |
Game information provided by Retrosheet (www.retrosheet.org) |
