| Wednesday, January 13 |
| Future Indian Steve Comer is born in Minneapolis, MN. |
| Wednesday, February 10 |
| Former Indian Heinie Berger dies in Lakewood, OH at the age of 73. |
| Sunday, March 7 |
| Future Indian Mike Armstrong is born in Glen Cove, NY. |
| Thursday, March 11 |
| Former Indian Bill Bradley dies in Cleveland, OH at the age of 77. |
| Saturday, April 3 |
| Future Indian Larry Littleton is born in Charlotte, NC. |
| Tuesday, April 13 |
| » Defeated White Sox (0-1), 8-2 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Early Wynn vs Billy Pierce | First | -- |
| Wednesday, April 14 |
| » Defeated White Sox (0-2), 6-3 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Bob Lemon vs Jack Harshman | First | -- |
| Future Indian Casey Parsons is born in Wenatchee, WA. |
| Thursday, April 15 |
| » Lost to Tigers (2-1), 3-2 | Cleveland Stadium (0-1) | 2-1 | |
| » Starters: Ted Gray vs Mike Garcia | First | -- |
| Saturday, April 17 |
| » Lost to White Sox (1-3), 8-1 | Cleveland Stadium (0-2) | 2-2 | Lost 2 |
| » Starters: Bob Keegan vs Art Houtteman | Fourth | 1 out |
| » Major-league debuts: Ray Narleski (Indians) |
| Sunday, April 18 |
| » Lost to White Sox (2-3), 6-2 | Cleveland Stadium (0-3) | 2-3 | Lost 3 |
| » Starters: Billy Pierce vs Early Wynn | Third | 2 out |
| Wednesday, April 21 |
| » Defeated Orioles (2-4), 2-1 | Memorial Stadium (1-0) | 3-3 | |
| » Starters: Bob Lemon vs Bob Turley | Second | ½ out |
| Thursday, April 22 |
| » Lost to Orioles (3-4), 4-1 | Memorial Stadium (1-1) | 3-4 | |
| » Starters: Mike Garcia vs Duane Pillette | Second | 1 out |
| Friday, April 23 |
| » Lost to Tigers (5-3), 6-1 | Tiger Stadium (0-1) | 3-5 | Lost 2 |
| » Starters: Early Wynn vs Ned Garver | Fifth | 2 out |
| Saturday, April 24 |
| » Lost to Tigers (6-3), 6-3 | Tiger Stadium (0-2) | 3-6 | Lost 3 |
| » Starters: Hal Newhouser vs Steve Gromek | Fifth | 3 out |
| Sunday, April 25 |
| » Defeated Tigers (6-4), 10-9 | Tiger Stadium (1-2) | 4-6 | |
| » Starters: Bob Lemon vs Billy Hoeft | Fourth | 2½ out |
| Thursday, April 29 |
| » Defeated Red Sox (4-7), 6-3 | Fenway Park (1-0) | 5-6 | Won 2 |
| » Starters: Mike Garcia vs Willard Nixon | Sixth | 2 out |
| Friday, April 30 |
| » Defeated Yankees (6-7), 9-4 | Yankee Stadium (1-0) | 6-6 | Won 3 |
| » Starters: Bob Lemon vs Tom Morgan | Fourth | 2 out |
| Saturday, May 1 |
| » Defeated Yankees (6-8), 10-2 | Yankee Stadium (2-0) | 7-6 | Won 4 |
| » Starters: Early Wynn vs Bill Miller | Fourth | 2 out |
| Sunday, May 2 |
| » Defeated Senators (6-8), 6-4 | Griffith Stadium (1-0) | 8-6 | Won 5 |
| » Starters: Bob Feller vs Chuck Stobbs | Third | 1 out |
| » Defeated Senators (6-9), 6-3 | Griffith Stadium (2-0) | 9-6 | Won 6 |
| » Starters: Art Houtteman vs Johnny Schmitz | Third | 1 out |
| Tuesday, May 4 |
| » Lost to Athletics (9-7), 3-2 | Shibe Park (0-1) | 9-7 | |
| » Starters: Mike Garcia vs Bob Trice | Third | 2½ out |
| Wednesday, May 5 |
| » Defeated Athletics (9-8), 7-2 | Shibe Park (1-1) | 10-7 | |
| » Starters: Bob Lemon vs Alex Kellner | Third | 1½ out |
| Thursday, May 6 |
| » Defeated Athletics (9-9), 3-2 | Shibe Park (2-1) | 11-7 | Won 2 |
| » Starters: Early Wynn vs Arnie Portocarrero | Third | 1½ out |
| Saturday, May 8 |
| » Defeated Orioles (5-12), 5-3 | Memorial Stadium (2-1) | 12-7 | Won 3 |
| » Starters: Mike Garcia vs Duane Pillette | Third | 2 out |
| Sunday, May 9 |
| » Lost to Orioles (6-12), 2-1 | Memorial Stadium (2-2) | 12-8 | |
| » Starters: Art Houtteman vs Bob Turley | Third | 2 out |
| Monday, May 10 |
| » Defeated Yankees (11-10), 8-7 | Cleveland Stadium (1-3) | 13-8 | |
| » Starters: Whitey Ford vs Bob Lemon | Second | 2½ out |
| Tuesday, May 11 |
| » Lost to Yankees (12-10), 5-3 | Cleveland Stadium (1-4) | 13-9 | |
| » Starters: Allie Reynolds vs Early Wynn | Third | 2½ out |
| Wednesday, May 12 |
| » Lost to Yankees (13-10), 5-4 | Cleveland Stadium (1-5) | 13-10 | Lost 2 |
| » Starters: Ed Lopat vs Mike Garcia | Third | 2½ out |
| Thursday, May 13 |
| » Defeated Senators (8-14), 8-7 | Cleveland Stadium (2-5) | 14-10 | |
| » Starters: Mickey McDermott vs Art Houtteman | Third | 2½ out |
| Friday, May 14 |
| » Defeated Senators (8-15), 5-2 | Cleveland Stadium (3-5) | 15-10 | Won 2 |
| » Starters: Chuck Stobbs vs Bob Lemon | Second | 1 out |
| Saturday, May 15 |
| » Defeated Senators (8-16), 5-4 | Cleveland Stadium (4-5) | 16-10 | Won 3 |
| » Starters: Spec Shea vs Early Wynn | Second | 1 out |
| Sunday, May 16 |
| » Defeated Athletics (10-16), 12-7 | Cleveland Stadium (5-5) | 17-10 | Won 4 |
| » Starters: Marion Fricano vs Bob Feller | First | -- |
| » Defeated Athletics (10-17), 6-0 | Cleveland Stadium (6-5) | 18-10 | Won 5 |
| » Starters: Arnie Portocarrero vs Mike Garcia | First | -- |
| Tuesday, May 18 |
| » Defeated Red Sox (7-16), 6-3 | Cleveland Stadium (7-5) | 19-10 | Won 6 |
| » Starters: Bill Henry vs Art Houtteman | First | -- |
| Wednesday, May 19 |
| » Defeated Red Sox (7-17), 5-3 | Cleveland Stadium (8-5) | 20-10 | Won 7 |
| » Starters: Willard Nixon vs Bob Lemon | First | -- |
| Future Indian Rick Cerone is born in Newark, NJ. |
| Friday, May 21 |
| » Defeated Orioles (12-16), 2-1 | Cleveland Stadium (9-5) | 21-10 | Won 8 |
| » Starters: Duane Pillette vs Early Wynn | First | -- |
| Saturday, May 22 |
| » Defeated Orioles (12-17), 4-3 | Cleveland Stadium (10-5) | 22-10 | Won 9 |
| » Starters: Don Larsen vs Mike Garcia | First | -- |
| Sunday, May 23 |
| » Defeated Orioles (12-18), 14-3 | Cleveland Stadium (11-5) | 23-10 | Won 10 |
| » Starters: Lou Kretlow vs Bob Feller | First | -- |
| » Defeated Orioles (12-19), 2-1 | Cleveland Stadium (12-5) | 24-10 | Won 11 |
| » Starters: Bob Turley vs Art Houtteman | First | -- |
| Tuesday, May 25 |
| » Lost to White Sox (23-13), 4-2 | Comiskey Park I (2-1) | 24-11 | |
| » Starters: Bob Lemon vs Billy Pierce | First | -- |
| Wednesday, May 26 |
| » Lost to White Sox (24-13), 5-4 | Comiskey Park I (2-2) | 24-12 | Lost 2 |
| » Starters: Mike Garcia vs Bob Keegan | First | -- |
| Friday, May 28 |
| » Defeated Tigers (19-14), 3-0 | Cleveland Stadium (13-5) | 25-12 | |
| » Starters: Steve Gromek vs Early Wynn | First | -- |
| Saturday, May 29 |
| » Defeated Tigers (19-15), 12-0 | Cleveland Stadium (14-5) | 26-12 | Won 2 |
| » Starters: Ray Herbert vs Bob Lemon | First | -- |
| Sunday, May 30 |
| » Defeated Tigers (19-16), 3-1 | Cleveland Stadium (15-5) | 27-12 | Won 3 |
| » Starters: Dick Marlowe vs Mike Garcia | First | -- |
| Monday, May 31 |
| » Lost to White Sox (28-14), 6-4 | Cleveland Stadium (15-6) | 27-13 | |
| » Starters: Bob Keegan vs Bob Feller | First | -- |
| » Defeated White Sox (28-15), 6-3 | Cleveland Stadium (16-6) | 28-13 | |
| » Starters: Don Johnson vs Art Houtteman | First | -- |
| Wednesday, June 2 |
| » Defeated Yankees (26-18), 8-7 | Yankee Stadium (3-0) | 29-13 | Won 2 |
| » Starters: Early Wynn vs Allie Reynolds | First | -- |
| Thursday, June 3 |
| » Lost to Yankees (27-18), 2-1 | Yankee Stadium (3-1) | 29-14 | |
| » Starters: Bob Lemon vs Ed Lopat | First | -- |
| Friday, June 4 |
| » Lost to Yankees (28-18), 8-3 | Yankee Stadium (3-2) | 29-15 | Lost 2 |
| » Starters: Early Wynn vs Whitey Ford | First | -- |
| Saturday, June 5 |
| » Defeated Athletics (17-29), 4-1 | Shibe Park (3-1) | 30-15 | |
| » Starters: Mike Garcia vs Alex Kellner | First | -- |
| Sunday, June 6 |
| » Defeated Athletics (17-30), 2-1 | Shibe Park (4-1) | 31-15 | Won 2 |
| » Starters: Bob Feller vs Arnie Portocarrero | First | -- |
| » Defeated Athletics (17-31), 7-5 | Shibe Park (5-1) | 32-15 | Won 3 |
| » Starters: Art Houtteman vs Marion Fricano | First | -- |
| Tuesday, June 8 |
| » Lost to Senators (20-28), 5-2 | Griffith Stadium (2-1) | 32-16 | |
| » Starters: Early Wynn vs Mickey McDermott | Second | 1 out |
| Wednesday, June 9 |
| » Defeated Senators (20-29), 1-0 | Griffith Stadium (3-1) | 33-16 | |
| » Starters: Mike Garcia vs Bob Porterfield | Second | 1 out |
| Thursday, June 10 |
| » Lost to Senators (21-29), 8-4 | Griffith Stadium (3-2) | 33-17 | |
| » Starters: Bob Lemon vs Dean Stone | Second | 1½ out |
| Friday, June 11 |
| » Defeated Red Sox (19-29), 6-2 | Fenway Park (2-0) | 34-17 | |
| » Starters: Art Houtteman vs Willard Nixon | Second | ½ out |
| Saturday, June 12 |
| » Defeated Red Sox (19-30), 4-3 | Fenway Park (3-0) | 35-17 | Won 2 |
| » Starters: Bob Feller vs Tom Brewer | First | -- |
| Sunday, June 13 |
| » Defeated Red Sox (19-31), 4-1 | Fenway Park (4-0) | 36-17 | Won 3 |
| » Starters: Early Wynn vs Frank Sullivan | First | -- |
| » Defeated Red Sox (19-32), 8-1 | Fenway Park (5-0) | 37-17 | Won 4 |
| » Starters: Mike Garcia vs Tex Clevenger | First | -- |
| Monday, June 14 |
| » Defeated Red Sox (19-33), 13-5 | Fenway Park (6-0) | 38-17 | Won 5 |
| » Starters: Bob Lemon vs Bill Henry | First | -- |
| Tuesday, June 15 |
| » Defeated Senators (23-32), 9-3 | Cleveland Stadium (17-6) | 39-17 | Won 6 |
| » Starters: Dean Stone vs Art Houtteman | First | -- |
| Wednesday, June 16 |
| » Defeated Senators (23-33), 5-1 | Cleveland Stadium (18-6) | 40-17 | Won 7 |
| » Starters: Mickey McDermott vs Don Mossi | First | -- |
| Thursday, June 17 |
| » Defeated Senators (23-34), 6-4 | Cleveland Stadium (19-6) | 41-17 | Won 8 |
| » Starters: Spec Shea vs Early Wynn | First | -- |
| Friday, June 18 |
| » Defeated Red Sox (20-36), 2-0 | Cleveland Stadium (20-6) | 42-17 | Won 9 |
| » Starters: Frank Sullivan vs Mike Garcia | First | -- |
| Saturday, June 19 |
| » Lost to Red Sox (21-36), 6-3 | Cleveland Stadium (20-7) | 42-18 | |
| » Starters: Ellis Kinder vs Bob Lemon | First | -- |
| Future Indian Johnnie LeMaster is born in Portsmouth, OH. |
| Sunday, June 20 |
| » Defeated Red Sox (21-37), 3-1 | Cleveland Stadium (21-7) | 43-18 | |
| » Starters: Leo Kiely vs Bob Feller | First | -- |
| » Defeated Red Sox (21-38), 9-2 | Cleveland Stadium (22-7) | 44-18 | Won 2 |
| » Starters: Willard Nixon vs Art Houtteman | First | -- |
| Tuesday, June 22 |
| » Lost to Athletics (25-36), 4-1 | Cleveland Stadium (22-8) | 44-19 | |
| » Starters: Al Sima vs Early Wynn | First | -- |
| Wednesday, June 23 |
| » Defeated Athletics (25-37), 5-2 | Cleveland Stadium (23-8) | 45-19 | |
| » Starters: Bob Trice vs Bob Lemon | First | -- |
| Thursday, June 24 |
| » Lost to Athletics (26-37), 5-1 | Cleveland Stadium (23-9) | 45-20 | |
| » Starters: Arnie Portocarrero vs Art Houtteman | First | -- |
| Friday, June 25 |
| » Lost to Yankees (43-25), 11-0 | Cleveland Stadium (23-10) | 45-21 | Lost 2 |
| » Starters: Allie Reynolds vs Mike Garcia | First | -- |
| Saturday, June 26 |
| » Lost to Yankees (44-25), 11-9 | Cleveland Stadium (23-11) | 45-22 | Lost 3 |
| » Starters: Ed Lopat vs Early Wynn | First | -- |
| Sunday, June 27 |
| » Defeated Yankees (44-26), 4-3 | Cleveland Stadium (24-11) | 46-22 | |
| » Starters: Whitey Ford vs Bob Lemon | First | -- |
| Tuesday, June 29 |
| » Defeated Orioles (27-43), 5-1 | Memorial Stadium (3-2) | 47-22 | Won 2 |
| » Starters: Art Houtteman vs Don Larsen | First | -- |
| Wednesday, June 30 |
| » Defeated Orioles (27-44), 2-0 | Memorial Stadium (4-2) | 48-22 | Won 3 |
| » Starters: Mike Garcia vs Duane Pillette | First | -- |
| Friday, July 2 |
| » Defeated White Sox (46-27), 3-2 | Cleveland Stadium (25-11) | 49-22 | Won 4 |
| » Starters: Virgil Trucks vs Bob Feller | First | -- |
| » Defeated White Sox (46-28), 5-4 | Cleveland Stadium (26-11) | 50-22 | Won 5 |
| » Starters: Don Johnson vs Early Wynn | First | -- |
| Saturday, July 3 |
| » Defeated White Sox (46-29), 5-4 | Cleveland Stadium (27-11) | 51-22 | Won 6 |
| » Starters: Sandy Consuegra vs Art Houtteman | First | -- |
| Sunday, July 4 |
| » Defeated White Sox (46-30), 2-1 | Cleveland Stadium (28-11) | 52-22 | Won 7 |
| » Starters: Bob Keegan vs Mike Garcia | First | -- |
| Monday, July 5 |
| » Defeated Tigers (31-41), 13-6 | Tiger Stadium (2-2) | 53-22 | Won 8 |
| » Starters: Dave Hoskins vs Ned Garver | First | -- |
| » Lost to Tigers (32-41), 1-0 | Tiger Stadium (2-3) | 53-23 | |
| » Starters: Don Mossi vs George Zuverink | First | -- |
| Tuesday, July 6 |
| » Defeated Orioles (30-47), 11-3 | Cleveland Stadium (29-11) | 54-23 | |
| » Starters: Joe Coleman vs Early Wynn | First | -- |
| Wednesday, July 7 |
| » Defeated Orioles (30-48), 6-1 | Cleveland Stadium (30-11) | 55-23 | Won 2 |
| » Starters: Bob Turley vs Mike Garcia | First | -- |
| Thursday, July 8 |
| » Defeated Orioles (30-49), 4-1 | Cleveland Stadium (31-11) | 56-23 | Won 3 |
| » Starters: Lou Kretlow vs Bob Feller | First | -- |
| Friday, July 9 |
| » Lost to White Sox (51-31), 8-3 | Comiskey Park I (2-3) | 56-24 | |
| » Starters: Art Houtteman vs Bob Keegan | First | -- |
| Saturday, July 10 |
| » Lost to White Sox (52-31), 3-0 | Comiskey Park I (2-4) | 56-25 | Lost 2 |
| » Starters: Early Wynn vs Jack Harshman | First | -- |
| Sunday, July 11 |
| » Lost to White Sox (53-31), 3-0 | Comiskey Park I (2-5) | 56-26 | Lost 3 |
| » Starters: Ray Narleski vs Billy Pierce | First | -- |
| » Lost to White Sox (54-31), 8-2 | Comiskey Park I (2-6) | 56-27 | Lost 4 |
| » Starters: Bob Lemon vs Virgil Trucks | First | -- |
| Thursday, July 15 |
| » Defeated Athletics (30-50), 4-0 | Shibe Park (6-1) | 57-27 | |
| » Starters: Early Wynn vs Alex Kellner | First | -- |
| Friday, July 16 |
| » Defeated Athletics (30-51), 9-3 | Shibe Park (7-1) | 58-27 | Won 2 |
| » Starters: Mike Garcia vs Arnie Portocarrero | First | -- |
| Saturday, July 17 |
| » Defeated Athletics (30-52), 6-0 | Shibe Park (8-1) | 59-27 | Won 3 |
| » Starters: Bob Feller vs Al Sima | First | -- |
| Sunday, July 18 |
| » Lost to Senators (35-48), 8-3 | Griffith Stadium (3-3) | 59-28 | |
| » Starters: Art Houtteman vs Chuck Stobbs | First | -- |
| » Defeated Senators (35-49), 7-4 | Griffith Stadium (4-3) | 60-28 | |
| » Starters: Bob Lemon vs Mickey McDermott | First | -- |
| Monday, July 19 |
| » Defeated Senators (35-50), 4-3 | Griffith Stadium (5-3) | 61-28 | Won 2 |
| » Starters: Early Wynn vs Spec Shea | First | -- |
| Tuesday, July 20 |
| » Tied Red Sox, 5-5 | Fenway Park (6-0) | 61-28 | |
| » Starters: Mike Garcia vs Willard Nixon | First | -- |
| Wednesday, July 21 |
| » Tied Red Sox, 7-7 | Fenway Park (6-0) | 61-28 | |
| » Starters: Art Houtteman vs Tom Brewer | First | -- |
| Thursday, July 22 |
| » Defeated Red Sox (37-51), 6-3 | Fenway Park (7-0) | 62-28 | Won 3 |
| » Starters: Bob Feller vs Frank Sullivan | First | -- |
| » Defeated Red Sox (37-52), 5-2 | Fenway Park (8-0) | 63-28 | Won 4 |
| » Starters: Bob Lemon vs Hal Brown | First | -- |
| Friday, July 23 |
| » Defeated Yankees (64-31), 8-2 | Yankee Stadium (4-2) | 64-28 | Won 5 |
| » Starters: Early Wynn vs Ed Lopat | First | -- |
| Saturday, July 24 |
| » Defeated Yankees (64-32), 5-4 | Yankee Stadium (5-2) | 65-28 | Won 6 |
| » Starters: Don Mossi vs Allie Reynolds | First | -- |
| Sunday, July 25 |
| » Lost to Yankees (65-32), 4-3 | Yankee Stadium (5-3) | 65-29 | |
| » Starters: Mike Garcia vs Whitey Ford | First | -- |
| Tuesday, July 27 |
| » Defeated Red Sox (38-56), 6-3 | Cleveland Stadium (32-11) | 66-29 | |
| » Starters: Frank Sullivan vs Bob Lemon | First | -- |
| Wednesday, July 28 |
| » Defeated Red Sox (38-57), 2-1 | Cleveland Stadium (33-11) | 67-29 | Won 2 |
| » Starters: Russ Kemmerer vs Early Wynn | First | -- |
| Thursday, July 29 |
| » Lost to Red Sox (39-57), 10-2 | Cleveland Stadium (33-12) | 67-30 | |
| » Starters: Leo Kiely vs Bob Feller | First | -- |
| Friday, July 30 |
| » Defeated Senators (42-53), 8-3 | Cleveland Stadium (34-12) | 68-30 | |
| » Starters: Dean Stone vs Art Houtteman | First | -- |
| Saturday, July 31 |
| » Defeated Senators (42-54), 6-0 | Cleveland Stadium (35-12) | 69-30 | Won 2 |
| » Starters: Spec Shea vs Bob Lemon | First | -- |
| Sunday, August 1 |
| » Defeated Senators (42-55), 3-1 | Cleveland Stadium (36-12) | 70-30 | Won 3 |
| » Starters: Johnny Schmitz vs Early Wynn | First | -- |
| » Defeated Senators (42-56), 5-4 | Cleveland Stadium (37-12) | 71-30 | Won 4 |
| » Starters: Bob Porterfield vs Mike Garcia | First | -- |
| Tuesday, August 3 |
| » Lost to Yankees (71-34), 2-1 | Cleveland Stadium (37-13) | 71-31 | |
| » Starters: Whitey Ford vs Don Mossi | First | -- |
| Wednesday, August 4 |
| » Defeated Yankees (71-35), 5-2 | Cleveland Stadium (38-13) | 72-31 | |
| » Starters: Allie Reynolds vs Bob Lemon | First | -- |
| Thursday, August 5 |
| » Lost to Yankees (72-35), 5-2 | Cleveland Stadium (38-14) | 72-32 | |
| » Starters: Bob Grim vs Early Wynn | First | -- |
| Friday, August 6 |
| » Defeated Athletics (37-68), 7-3 | Cleveland Stadium (39-14) | 73-32 | |
| » Starters: Al Sima vs Mike Garcia | First | -- |
| Future Indian Ken Phelps is born in Seattle, WA. |
| Saturday, August 7 |
| » Defeated Athletics (37-69), 5-1 | Cleveland Stadium (40-14) | 74-32 | Won 2 |
| » Starters: Johnny Gray vs Bob Feller | First | -- |
| Sunday, August 8 |
| » Defeated Athletics (37-70), 7-2 | Cleveland Stadium (41-14) | 75-32 | Won 3 |
| » Starters: Arnie Portocarrero vs Bob Lemon | First | -- |
| » Defeated Athletics (37-71), 5-2 | Cleveland Stadium (42-14) | 76-32 | Won 4 |
| » Starters: Alex Kellner vs Art Houtteman | First | -- |
| Tuesday, August 10 |
| » Lost to Tigers (50-59), 4-0 | Tiger Stadium (2-4) | 76-33 | |
| » Starters: Early Wynn vs Ned Garver | First | -- |
| Wednesday, August 11 |
| » Defeated Tigers (50-60), 2-0 | Tiger Stadium (3-4) | 77-33 | |
| » Starters: Mike Garcia vs Steve Gromek | First | -- |
| Thursday, August 12 |
| » Defeated Tigers (50-61), 10-1 | Tiger Stadium (4-4) | 78-33 | Won 2 |
| » Starters: Bob Lemon vs George Zuverink | First | -- |
| Friday, August 13 |
| » Defeated Orioles (39-74), 9-4 | Cleveland Stadium (43-14) | 79-33 | Won 3 |
| » Starters: Bob Turley vs Bob Feller | First | -- |
| Saturday, August 14 |
| » Defeated Orioles (39-75), 4-3 | Cleveland Stadium (44-14) | 80-33 | Won 4 |
| » Starters: Don Larsen vs Early Wynn | First | -- |
| Sunday, August 15 |
| » Defeated Orioles (39-76), 5-2 | Cleveland Stadium (45-14) | 81-33 | Won 5 |
| » Starters: Joe Coleman vs Art Houtteman | First | -- |
| » Defeated Orioles (39-77), 3-1 | Cleveland Stadium (46-14) | 82-33 | Won 6 |
| » Starters: Lou Kretlow vs Mike Garcia | First | -- |
| Tuesday, August 17 |
| » Defeated Tigers (52-64), 4-3 | Cleveland Stadium (47-14) | 83-33 | Won 7 |
| » Starters: George Zuverink vs Bob Lemon | First | -- |
| Wednesday, August 18 |
| » Defeated Tigers (52-65), 4-0 | Cleveland Stadium (48-14) | 84-33 | Won 8 |
| » Starters: Billy Hoeft vs Early Wynn | First | -- |
| Thursday, August 19 |
| » Defeated Tigers (52-66), 4-3 | Cleveland Stadium (49-14) | 85-33 | Won 9 |
| » Starters: Ned Garver vs Bob Feller | First | -- |
| » Lost to Tigers (53-66), 8-2 | Cleveland Stadium (49-15) | 85-34 | |
| » Starters: Al Aber vs Mike Garcia | First | -- |
| Friday, August 20 |
| » Defeated Orioles (39-82), 7-2 | Memorial Stadium (5-2) | 86-34 | |
| » Starters: Art Houtteman vs Joe Coleman | First | -- |
| Saturday, August 21 |
| » Defeated Orioles (39-83), 4-1 | Memorial Stadium (6-2) | 87-34 | Won 2 |
| » Starters: Bob Lemon vs Bob Turley | First | -- |
| Sunday, August 22 |
| » Defeated Orioles (39-84), 12-1 | Memorial Stadium (7-2) | 88-34 | Won 3 |
| » Starters: Early Wynn vs Bob Kuzava | First | -- |
| Tuesday, August 24 |
| » Lost to Athletics (41-81), 4-1 | Shibe Park (8-2) | 88-35 | |
| » Starters: Mike Garcia vs Johnny Gray | First | -- |
| Wednesday, August 25 |
| » Defeated Athletics (41-82), 4-3 | Shibe Park (9-2) | 89-35 | |
| » Starters: Bob Lemon vs Sonny Dixon | First | -- |
| Thursday, August 26 |
| » Defeated Senators (51-72), 2-1 | Griffith Stadium (6-3) | 90-35 | Won 2 |
| » Starters: Early Wynn vs Mickey McDermott | First | -- |
| Friday, August 27 |
| » Lost to Senators (52-72), 3-2 | Griffith Stadium (6-4) | 90-36 | |
| » Starters: Bob Feller vs Johnny Schmitz | First | -- |
| Saturday, August 28 |
| » Defeated Senators (52-73), 5-2 | Griffith Stadium (7-4) | 91-36 | |
| » Starters: Mike Garcia vs Chuck Stobbs | First | -- |
| Sunday, August 29 |
| » Defeated Red Sox (56-70), 6-2 | Fenway Park (9-0) | 92-36 | Won 2 |
| » Starters: Bob Lemon vs Tom Brewer | First | -- |
| » Defeated Red Sox (56-71), 8-1 | Fenway Park (10-0) | 93-36 | Won 3 |
| » Starters: Art Houtteman vs Frank Sullivan | First | -- |
| Monday, August 30 |
| » Defeated Red Sox (56-72), 5-4 | Fenway Park (11-0) | 94-36 | Won 4 |
| » Starters: Ray Narleski vs Willard Nixon | First | -- |
| Tuesday, August 31 |
| » Defeated Yankees (89-41), 6-1 | Yankee Stadium (6-3) | 95-36 | Won 5 |
| » Starters: Early Wynn vs Bob Grim | First | -- |
| Future Indian Jack Perconte is born in Joliet, IL. |
| Wednesday, September 1 |
| » Lost to Yankees (90-41), 4-1 | Yankee Stadium (6-4) | 95-37 | |
| » Starters: Mike Garcia vs Ed Lopat | First | -- |
| Thursday, September 2 |
| » Lost to Yankees (91-41), 3-2 | Yankee Stadium (6-5) | 95-38 | Lost 2 |
| » Starters: Bob Lemon vs Whitey Ford | First | -- |
| Future Indian Rick Manning is born in Niagara Falls, NY. |
| Friday, September 3 |
| » Defeated White Sox (86-49), 3-2 | Comiskey Park I (3-6) | 96-38 | |
| » Starters: Bob Feller vs Virgil Trucks | First | -- |
| Saturday, September 4 |
| » Lost to White Sox (87-49), 8-5 | Comiskey Park I (3-7) | 96-39 | |
| » Starters: Early Wynn vs Jack Harshman | First | -- |
| Sunday, September 5 |
| » Defeated White Sox (87-50), 8-2 | Comiskey Park I (4-7) | 97-39 | |
| » Starters: Art Houtteman vs Billy Pierce | First | -- |
| Monday, September 6 |
| » Defeated Orioles (44-93), 6-1 | Memorial Stadium (8-2) | 98-39 | Won 2 |
| » Starters: Bob Lemon vs Duane Pillette | First | -- |
| » Lost to Orioles (45-93), 3-2 | Memorial Stadium (8-3) | 98-40 | |
| » Starters: Mike Garcia vs Don Larsen | First | -- |
| Wednesday, September 8 |
| » Defeated Athletics (46-93), 5-2 | Cleveland Stadium (50-15) | 99-40 | |
| » Starters: Johnny Gray vs Early Wynn | First | -- |
| Thursday, September 9 |
| » Defeated Athletics (46-94), 5-4 | Cleveland Stadium (51-15) | 100-40 | Won 2 |
| » Starters: Arnie Portocarrero vs Bob Feller | First | -- |
| Friday, September 10 |
| » Defeated Red Sox (63-76), 4-2 | Cleveland Stadium (52-15) | 101-40 | Won 3 |
| » Starters: Leo Kiely vs Mike Garcia | First | -- |
| Saturday, September 11 |
| » Defeated Red Sox (63-77), 3-0 | Cleveland Stadium (53-15) | 102-40 | Won 4 |
| » Starters: Mel Parnell vs Art Houtteman | First | -- |
| Sunday, September 12 |
| » Defeated Yankees (95-47), 4-1 | Cleveland Stadium (54-15) | 103-40 | Won 5 |
| » Starters: Whitey Ford vs Bob Lemon | First | -- |
| » Defeated Yankees (95-48), 3-2 | Cleveland Stadium (55-15) | 104-40 | Won 6 |
| » Starters: Tommy Byrne vs Early Wynn | First | -- |
| Tuesday, September 14 |
| » Defeated Senators (61-83), 4-2 | Cleveland Stadium (56-15) | 105-40 | Won 7 |
| » Starters: Chuck Stobbs vs Mike Garcia | First | -- |
| Friday, September 17 |
| » Defeated Tigers (64-82), 6-3 | Tiger Stadium (5-4) | 106-40 | Won 8 |
| » Starters: Bob Lemon vs Ned Garver | First | -- |
| » Major-league debuts: George Bullard (Tigers) |
| Saturday, September 18 |
| » Defeated Tigers (64-83), 3-2 | Tiger Stadium (6-4) | 107-40 | Won 9 |
| » Starters: Early Wynn vs Steve Gromek | First | -- |
| Sunday, September 19 |
| » Defeated Tigers (64-84), 4-2 | Tiger Stadium (7-4) | 108-40 | Won 10 |
| » Starters: Mike Garcia vs Ted Gray | First | -- |
| Monday, September 20 |
| » Defeated White Sox (92-58), 7-4 | Cleveland Stadium (57-15) | 109-40 | Won 11 |
| » Starters: Bob Keegan vs Bob Feller | First | -- |
| Tuesday, September 21 |
| » Lost to White Sox (93-58), 9-7 | Cleveland Stadium (57-16) | 109-41 | |
| » Starters: Mike Fornieles vs Art Houtteman | First | -- |
| Wednesday, September 22 |
| » Defeated White Sox (93-59), 3-1 | Cleveland Stadium (58-16) | 110-41 | |
| » Starters: Jack Harshman vs Don Mossi | First | -- |
| Friday, September 24 |
| » Lost to Tigers (67-85), 6-4 | Cleveland Stadium (58-17) | 110-42 | |
| » Starters: Ted Gray vs Bob Lemon | First | -- |
| Saturday, September 25 |
| » Defeated Tigers (67-86), 11-1 | Cleveland Stadium (59-17) | 111-42 | |
| » Starters: George Zuverink vs Early Wynn | First | -- |
| Sunday, September 26 |
| » Lost to Tigers (68-86), 8-7 | Cleveland Stadium (59-18) | 111-43 | |
| » Starters: Ned Garver vs Mike Garcia | First | -- |
| Sunday, October 3 |
| Future Indian Dennis Eckersley is born in Oakland, CA. |
| Wednesday, October 13 |
| Future Indian George Frazier is born in Oklahoma City, OK. |
| Friday, October 22 |
| Future Indian Jamie Quirk is born in Whittier, CA. Former Indian Earl Whitehill dies in Omaha, NE at the age of 55 |
| Thursday, October 28 |
| Future Indian Sammy Stewart is born in Asheville, NC. |
| Monday, November 1 |
| Future Indian Miguel Dilone is born in Santiago, D.R. |
| Tuesday, November 23 |
| Future Indian Broderick Perkins is born in Pittsburg, CA. Future Indian Ken Schrom is born in Grangeville, ID. |
| Wednesday, December 1 |
| Future Indian Dan Schatzeder is born in Elmhurst, IL. |
| Sunday, December 5 |
| Former Indian Russ Christopher dies in Richmond, CA at the age of 38. |
Game information provided by Retrosheet (www.retrosheet.org) |
