| Tuesday, January 5 |
| Former Cub Rabbit Maranville dies in New York, NY at the age of 63. |
| Saturday, February 13 |
| Future Cub Donnie Moore is born in Lubbock, TX. |
| Thursday, March 11 |
| Former Cub Bill Bradley dies in Cleveland, OH at the age of 77. |
| Tuesday, March 16 |
| Former Cub George Grantham dies in Kingman, AZ at the age of 54. |
| Tuesday, April 13 |
| » Defeated Cardinals (0-1), 13-4 | Sportsman's Park III (1-0) | 1-0 | |
| » Starters: Paul Minner vs Harvey Haddix | First | -- |
| » Major-league debuts: Tom Alston Alex Grammas and Wally Moon (Cardinals) |
| Wednesday, April 14 |
| » Major-league debuts: Bob Purkey (Pirates) |
| Thursday, April 15 |
| » Lost to Reds (2-0), 11-5 | Wrigley Field (0-1) | 1-1 | |
| » Starters: Fred Baczewski vs Bob Rush | Third | 1 out |
| » Major-league debuts: Jim Brosnan (Cubs) |
| Saturday, April 17 |
| » Defeated Cardinals (0-3), 23-13 | Wrigley Field (1-1) | 2-1 | |
| » Starters: Gerry Staley vs Johnny Klippstein | First | -- |
| » Major-league debuts: Mel Wright (Cardinals) |
| Sunday, April 18 |
| » Lost to Cardinals (1-3), 6-4 | Wrigley Field (1-2) | 2-2 | |
| » Starters: Vic Raschi vs Paul Minner | Second | 1½ out |
| » Major-league debuts: Jim Davis (Cubs) |
| Tuesday, April 20 |
| » Major-league debuts: Memo Luna (Cardinals) |
| Future Cub Mike O'Berry is born in Birmingham, AL. |
| Wednesday, April 21 |
| » Lost to Braves (3-3), 7-3 | County Stadium (0-1) | 2-3 | Lost 2 |
| » Starters: Johnny Klippstein vs Warren Spahn | Fifth | 1½ out |
| Friday, April 23 |
| » Defeated Reds (5-4), 10-3 | Crosley Field (1-0) | 3-3 | |
| » Starters: Bob Rush vs Fred Baczewski | Fourth | 1 out |
| Saturday, April 24 |
| » Lost to Reds (6-4), 6-5 | Crosley Field (1-1) | 3-4 | |
| » Starters: Paul Minner vs Bud Podbielan | Sixth | 2 out |
| » Major-league debuts: Elvin Tappe (Cubs) |
| Sunday, April 25 |
| » Defeated Reds (6-5), 9-2 | Crosley Field (2-1) | 4-4 | |
| » Starters: Bubba Church vs Howie Judson | Sixth | 2 out |
| » Lost to Reds (7-5), 3-2 | Crosley Field (2-2) | 4-5 | |
| » Starters: Howie Pollet vs Art Fowler | Sixth | 2 out |
| Wednesday, April 28 |
| » Major-league debuts: Tim Thompson (Dodgers) |
| Friday, April 30 |
| » Lost to Giants (8-6), 4-2 | Wrigley Field (1-3) | 4-6 | Lost 2 |
| » Starters: Sal Maglie vs Bob Rush | Fifth | 2½ out |
| Future Cub Joe Strain is born in Denver, CO. |
| Saturday, May 1 |
| » Defeated Giants (8-7), 4-3 | Wrigley Field (2-3) | 5-6 | |
| » Starters: Marv Grissom vs Johnny Klippstein | Fifth | 3 out |
| Sunday, May 2 |
| » Defeated Pirates (6-12), 5-3 | Wrigley Field (3-3) | 6-6 | Won 2 |
| » Starters: Vern Law vs Paul Minner | Fifth | 2 out |
| » Lost to Pirates (7-12), 18-10 | Wrigley Field (3-4) | 6-7 | |
| » Starters: Bob Friend vs Bubba Church | Fifth | 2 out |
| Future Cub Keith Moreland is born in Dallas, TX. |
| Wednesday, May 5 |
| » Lost to Dodgers (10-7), 7-0 | Wrigley Field (3-5) | 6-8 | Lost 2 |
| » Starters: Russ Meyer vs Bob Rush | Seventh | 3½ out |
| Thursday, May 6 |
| » Defeated Dodgers (10-8), 8-7 | Wrigley Field (4-5) | 7-8 | |
| » Starters: Carl Erskine vs Johnny Klippstein | Sixth | 3 out |
| Friday, May 7 |
| » Defeated Braves (8-10), 3-0 | County Stadium (1-1) | 8-8 | Won 2 |
| » Starters: Warren Hacker vs Bob Buhl | Fourth | 2½ out |
| Saturday, May 8 |
| » Lost to Braves (9-10), 3-2 | County Stadium (1-2) | 8-9 | |
| » Starters: Paul Minner vs Chet Nichols | Seventh | 2½ out |
| Sunday, May 9 |
| » Defeated Braves (9-11), 5-3 | County Stadium (2-2) | 9-9 | |
| » Starters: Bob Rush vs Warren Spahn | Fifth | 2½ out |
| Tuesday, May 11 |
| » Lost to Phillies (12-9), 8-7 | Shibe Park (0-1) | 9-10 | |
| » Starters: Johnny Klippstein vs Bob Miller | Sixth | 2½ out |
| Wednesday, May 12 |
| » Lost to Phillies (13-9), 5-4 | Shibe Park (0-2) | 9-11 | Lost 2 |
| » Starters: Warren Hacker vs Curt Simmons | Sixth | 3 out |
| Thursday, May 13 |
| » Lost to Giants (14-11), 6-3 | Polo Grounds V (0-1) | 9-12 | Lost 3 |
| » Starters: Bubba Church vs Larry Jansen | Seventh | 4 out |
| Friday, May 14 |
| » Lost to Giants (15-11), 9-6 | Polo Grounds V (0-2) | 9-13 | Lost 4 |
| » Starters: Bob Rush vs Sal Maglie | Seventh | 4 out |
| Saturday, May 15 |
| » Defeated Giants (15-12), 4-3 | Polo Grounds V (1-2) | 10-13 | |
| » Starters: Johnny Klippstein vs Jim Hearn | Seventh | 4 out |
| Sunday, May 16 |
| » Defeated Pirates (9-20), 12-3 | Forbes Field (1-0) | 11-13 | Won 2 |
| » Starters: Paul Minner vs Bob Friend | Seventh | 4 out |
| » Lost to Pirates (10-20), 5-1 | Forbes Field (1-1) | 11-14 | |
| » Starters: Jim Willis vs Jake Thies | Seventh | 4 out |
| Monday, May 17 |
| » Defeated Pirates (10-21), 10-6 | Forbes Field (2-1) | 12-14 | |
| » Starters: Howie Pollet vs Bob Purkey | Sixth | 3 out |
| Tuesday, May 18 |
| » Defeated Dodgers (16-13), 7-1 | Ebbets Field (1-0) | 13-14 | Won 2 |
| » Starters: Warren Hacker vs Billy Loes | Sixth | 2 out |
| Wednesday, May 19 |
| » Defeated Dodgers (16-14), 9-3 | Ebbets Field (2-0) | 14-14 | Won 3 |
| » Starters: Bob Rush vs Carl Erskine | Sixth | 2 out |
| Friday, May 21 |
| » Lost to Braves (16-14), 6-4 | Wrigley Field (4-6) | 14-15 | |
| » Starters: Gene Conley vs Johnny Klippstein | Sixth | 3½ out |
| Saturday, May 22 |
| » Lost to Braves (17-14), 5-1 | Wrigley Field (4-7) | 14-16 | Lost 2 |
| » Starters: Lew Burdette vs Paul Minner | Sixth | 4 out |
| » Lost to Braves (18-14), 11-9 | Wrigley Field (4-8) | 14-17 | Lost 3 |
| » Starters: Bob Buhl vs Warren Hacker | Sixth | 4 out |
| Sunday, May 23 |
| » Lost to Braves (19-14), 4-2 | Wrigley Field (4-9) | 14-18 | Lost 4 |
| » Starters: Ray Crone vs Howie Pollet | Sixth | 5½ out |
| » Lost to Braves (20-14), 9-3 | Wrigley Field (4-10) | 14-19 | Lost 5 |
| » Starters: Chet Nichols vs Bob Rush | Sixth | 5½ out |
| Monday, May 24 |
| » Defeated Cardinals (20-17), 6-2 | Sportsman's Park III (2-0) | 15-19 | |
| » Starters: Jim Davis vs Vic Raschi | Seventh | 5 out |
| Tuesday, May 25 |
| » Lost to Cardinals (21-17), 9-4 | Sportsman's Park III (2-1) | 15-20 | |
| » Starters: Johnny Klippstein vs Harvey Haddix | Seventh | 6 out |
| Wednesday, May 26 |
| » Defeated Cardinals (21-18), 15-5 | Sportsman's Park III (3-1) | 16-20 | |
| » Starters: Paul Minner vs Tom Poholsky | Seventh | 6 out |
| Thursday, May 27 |
| » Defeated Cardinals (21-19), 7-3 | Sportsman's Park III (4-1) | 17-20 | Won 2 |
| » Starters: Bob Rush vs Gerry Staley | Seventh | 5½ out |
| Friday, May 28 |
| » Lost to Reds (20-19), 6-3 | Wrigley Field (4-11) | 17-21 | |
| » Starters: Art Fowler vs Jim Davis | Seventh | 6½ out |
| Saturday, May 29 |
| » Defeated Reds (20-20), 6-0 | Wrigley Field (5-11) | 18-21 | |
| » Starters: Fred Baczewski vs Howie Pollet | Seventh | 5½ out |
| Sunday, May 30 |
| » Defeated Reds (20-21), 7-5 | Wrigley Field (6-11) | 19-21 | Won 2 |
| » Starters: Herm Wehmeier vs Hal Jeffcoat | Fifth | 5 out |
| » Lost to Reds (21-21), 6-5 | Wrigley Field (6-12) | 19-22 | |
| » Starters: Corky Valentine vs Johnny Klippstein | Fifth | 5 out |
| Monday, May 31 |
| » Defeated Cardinals (23-21), 14-4 | Wrigley Field (7-12) | 20-22 | |
| » Starters: Bill Greason vs Paul Minner | Seventh | 4½ out |
| Friday, June 4 |
| » Lost to Dodgers (26-18), 2-1 | Wrigley Field (7-13) | 20-23 | |
| » Starters: Carl Erskine vs Bob Rush | Seventh | 5½ out |
| Saturday, June 5 |
| » Lost to Dodgers (27-18), 8-5 | Wrigley Field (7-14) | 20-24 | Lost 2 |
| » Starters: Russ Meyer vs Johnny Klippstein | Seventh | 7½ out |
| » Lost to Dodgers (28-18), 8-3 | Wrigley Field (7-15) | 20-25 | Lost 3 |
| » Starters: Johnny Podres vs Warren Hacker | Seventh | 7½ out |
| Sunday, June 6 |
| » Lost to Dodgers (29-18), 6-4 | Wrigley Field (7-16) | 20-26 | Lost 4 |
| » Starters: Don Newcombe vs Paul Minner | Sixth | 8½ out |
| Tuesday, June 8 |
| » Defeated Phillies (25-21), 6-5 | Wrigley Field (8-16) | 21-26 | |
| » Starters: Robin Roberts vs Howie Pollet | Seventh | 8 out |
| Wednesday, June 9 |
| » Lost to Phillies (26-21), 4-0 | Wrigley Field (8-17) | 21-27 | |
| » Starters: Murry Dickson vs Bob Rush | Sixth | 8½ out |
| » Lost to Phillies (27-21), 14-6 | Wrigley Field (8-18) | 21-28 | Lost 2 |
| » Starters: Bob Miller vs Jim Davis | Sixth | 8½ out |
| Thursday, June 10 |
| » Lost to Phillies (28-21), 6-0 | Wrigley Field (8-19) | 21-29 | Lost 3 |
| » Starters: Steve Ridzik vs Paul Minner | Sixth | 9½ out |
| Friday, June 11 |
| » Defeated Giants (31-21), 5-4 | Wrigley Field (9-19) | 22-29 | |
| » Starters: Jim Hearn vs Johnny Klippstein | Seventh | 9½ out |
| Saturday, June 12 |
| » Lost to Giants (32-21), 5-0 | Wrigley Field (9-20) | 22-30 | |
| » Starters: Sal Maglie vs Warren Hacker | Sixth | 9½ out |
| Sunday, June 13 |
| » Lost to Giants (33-21), 9-3 | Wrigley Field (9-21) | 22-31 | Lost 2 |
| » Starters: Johnny Antonelli vs Bob Rush | Fifth | 11½ out |
| » Lost to Giants (34-21), 9-4 | Wrigley Field (9-22) | 22-32 | Lost 3 |
| » Starters: Don Liddle vs Howie Pollet | Fifth | 11½ out |
| Monday, June 14 |
| » Defeated Pirates (18-41), 6-5 | Forbes Field (3-1) | 23-32 | |
| » Starters: Jim Davis vs Max Surkont | Fifth | 11 out |
| Friday, June 18 |
| » Lost to Dodgers (36-23), 6-3 | Ebbets Field (2-1) | 23-33 | |
| » Starters: Warren Hacker vs Don Newcombe | Seventh | 12½ out |
| Saturday, June 19 |
| » Lost to Dodgers (37-23), 6-2 | Ebbets Field (2-2) | 23-34 | Lost 2 |
| » Starters: Bob Rush vs Russ Meyer | Seventh | 13½ out |
| Sunday, June 20 |
| » Lost to Dodgers (38-23), 6-4 | Ebbets Field (2-3) | 23-35 | Lost 3 |
| » Starters: Johnny Klippstein vs Carl Erskine | Sixth | 15 out |
| » Lost to Dodgers (39-23), 6-3 | Ebbets Field (2-4) | 23-36 | Lost 4 |
| » Starters: Hal Jeffcoat vs Billy Loes | Sixth | 15 out |
| Tuesday, June 22 |
| » Lost to Phillies (30-29), 4-1 | Shibe Park (0-3) | 23-37 | Lost 5 |
| » Starters: Paul Minner vs Robin Roberts | Seventh | 16½ out |
| Wednesday, June 23 |
| » Lost to Phillies (31-29), 5-3 | Shibe Park (0-4) | 23-38 | Lost 6 |
| » Starters: Howie Pollet vs Curt Simmons | Sixth | 16½ out |
| Thursday, June 24 |
| » Lost to Phillies (32-29), 3-2 | Shibe Park (0-5) | 23-39 | Lost 7 |
| » Starters: Jim Davis vs Herm Wehmeier | Seventh | 17½ out |
| Friday, June 25 |
| » Lost to Giants (43-23), 6-2 | Polo Grounds V (1-3) | 23-40 | Lost 8 |
| » Starters: Bob Rush vs Jim Hearn | Sixth | 18½ out |
| Saturday, June 26 |
| » Lost to Giants (44-23), 6-4 | Polo Grounds V (1-4) | 23-41 | Lost 9 |
| » Starters: Johnny Klippstein vs Johnny Antonelli | Sixth | 19½ out |
| Former Cub Charlie Pick dies in Lynchburg, VA at the age of 67. |
| Sunday, June 27 |
| » Lost to Giants (45-23), 3-2 | Polo Grounds V (1-5) | 23-42 | Lost 10 |
| » Starters: Warren Hacker vs Ruben Gomez | Seventh | 20½ out |
| Tuesday, June 29 |
| » Lost to Braves (34-33), 7-0 | County Stadium (2-3) | 23-43 | Lost 11 |
| » Starters: Paul Minner vs Jim Wilson | Seventh | 21½ out |
| Wednesday, June 30 |
| » Defeated Braves (34-34), 9-7 | County Stadium (3-3) | 24-43 | |
| » Starters: Bob Rush vs Lew Burdette | Seventh | 21½ out |
| Friday, July 2 |
| » Defeated Cardinals (34-37), 7-6 | Wrigley Field (10-22) | 25-43 | Won 2 |
| » Starters: Vic Raschi vs Howie Pollet | Seventh | 22 out |
| Saturday, July 3 |
| » Defeated Cardinals (34-38), 4-1 | Wrigley Field (11-22) | 26-43 | Won 3 |
| » Starters: Ralph Beard vs Warren Hacker | Seventh | 21 out |
| Sunday, July 4 |
| » Defeated Cardinals (34-39), 4-2 | Wrigley Field (12-22) | 27-43 | Won 4 |
| » Starters: Joe Presko vs Paul Minner | Seventh | 21 out |
| » Lost to Cardinals (35-39), 7-0 | Wrigley Field (12-23) | 27-44 | |
| » Starters: Royce Lint vs Johnny Klippstein | Seventh | 21 out |
| Future Cub Dan Larson is born in Los Angeles, CA. |
| Monday, July 5 |
| » Lost to Reds (37-38), 6-5 | Crosley Field (2-3) | 27-45 | Lost 2 |
| » Starters: Jim Davis vs Art Fowler | Seventh | 23 out |
| » Lost to Reds (38-38), 8-7 | Crosley Field (2-4) | 27-46 | Lost 3 |
| » Starters: Bob Rush vs Karl Drews | Seventh | 23 out |
| Tuesday, July 6 |
| » Lost to Braves (39-37), 14-3 | Wrigley Field (12-24) | 27-47 | Lost 4 |
| » Starters: Gene Conley vs Dave Cole | Seventh | 24 out |
| Wednesday, July 7 |
| » Lost to Braves (40-37), 1-0 | Wrigley Field (12-25) | 27-48 | Lost 5 |
| » Starters: Chet Nichols vs Howie Pollet | Seventh | 25 out |
| Thursday, July 8 |
| » Defeated Braves (40-38), 9-8 | Wrigley Field (13-25) | 28-48 | |
| » Starters: Lew Burdette vs Warren Hacker | Sixth | 25 out |
| Friday, July 9 |
| » Defeated Cardinals (38-42), 6-4 | Sportsman's Park III (5-1) | 29-48 | Won 2 |
| » Starters: Paul Minner vs Royce Lint | Seventh | 25 out |
| Saturday, July 10 |
| » Lost to Cardinals (39-42), 2-1 | Sportsman's Park III (5-2) | 29-49 | |
| » Starters: Bob Rush vs Vic Raschi | Seventh | 25 out |
| Future Cub Andre Dawson is born in Miami, FL. |
| Sunday, July 11 |
| » Lost to Cardinals (40-42), 4-3 | Sportsman's Park III (5-3) | 29-50 | Lost 2 |
| » Starters: Howie Pollet vs Gerry Staley | Seventh | 25½ out |
| Wednesday, July 14 |
| Future Cub Chuck Rainey is born in San Diego, CA. |
| Thursday, July 15 |
| » Defeated Pirates (27-56), 9-2 | Wrigley Field (14-25) | 30-50 | |
| » Starters: Max Surkont vs Paul Minner | Sixth | 25 out |
| » Defeated Pirates (27-57), 3-0 | Wrigley Field (15-25) | 31-50 | Won 2 |
| » Starters: George O'Donnell vs Warren Hacker | Sixth | 25 out |
| Friday, July 16 |
| » Defeated Pirates (27-58), 3-2 | Wrigley Field (16-25) | 32-50 | Won 3 |
| » Starters: Jake Thies vs Bob Rush | Seventh | 24 out |
| Saturday, July 17 |
| » Defeated Pirates (27-59), 11-3 | Wrigley Field (17-25) | 33-50 | Won 4 |
| » Starters: Vern Law vs Jim Davis | Seventh | 24½ out |
| » Lost to Pirates (28-59), 6-2 | Wrigley Field (17-26) | 33-51 | |
| » Starters: Bob Purkey vs Johnny Klippstein | Seventh | 24½ out |
| Sunday, July 18 |
| » Lost to Dodgers (54-35), 12-6 | Wrigley Field (17-27) | 33-52 | Lost 2 |
| » Starters: Russ Meyer vs Dave Cole | Seventh | 25 out |
| Monday, July 19 |
| » Defeated Dodgers (54-36), 9-4 | Wrigley Field (18-27) | 34-52 | |
| » Starters: Bob Milliken vs Warren Hacker | Seventh | 24 out |
| Tuesday, July 20 |
| » Defeated Dodgers (54-37), 3-2 | Wrigley Field (19-27) | 35-52 | Won 2 |
| » Starters: Erv Palica vs Paul Minner | Seventh | 24 out |
| Future Cub Gary Woods is born in Santa Barbara, CA. |
| Wednesday, July 21 |
| » Lost to Giants (62-30), 2-1 | Wrigley Field (19-28) | 35-53 | |
| » Starters: Sal Maglie vs Bob Rush | Seventh | 25 out |
| Thursday, July 22 |
| » Defeated Giants (62-31), 13-5 | Wrigley Field (20-28) | 36-53 | |
| » Starters: Jim Hearn vs Jim Davis | Seventh | 24 out |
| Friday, July 23 |
| » Defeated Phillies (43-45), 5-2 | Wrigley Field (21-28) | 37-53 | Won 2 |
| » Starters: Herm Wehmeier vs Howie Pollet | Seventh | 23½ out |
| » Lost to Phillies (44-45), 5-3 | Wrigley Field (21-29) | 37-54 | |
| » Starters: Bob Miller vs Warren Hacker | Seventh | 23½ out |
| Saturday, July 24 |
| » Defeated Phillies (44-46), 4-0 | Wrigley Field (22-29) | 38-54 | |
| » Starters: Curt Simmons vs Dave Cole | Seventh | 22½ out |
| Sunday, July 25 |
| » Defeated Phillies (44-47), 6-1 | Wrigley Field (23-29) | 39-54 | Won 2 |
| » Starters: Steve Ridzik vs Paul Minner | Seventh | 21 out |
| » Defeated Phillies (44-48), 2-1 | Wrigley Field (24-29) | 40-54 | Won 3 |
| » Starters: Bob Greenwood vs Bob Rush | Seventh | 21 out |
| Tuesday, July 27 |
| » Lost to Dodgers (60-38), 7-6 | Ebbets Field (2-5) | 40-55 | |
| » Starters: Warren Hacker vs Don Newcombe | Seventh | 20½ out |
| Wednesday, July 28 |
| » Lost to Dodgers (61-38), 3-1 | Ebbets Field (2-6) | 40-56 | Lost 2 |
| » Starters: Dave Cole vs Russ Meyer | Seventh | 21½ out |
| Thursday, July 29 |
| » Defeated Dodgers (61-39), 6-5 | Ebbets Field (3-6) | 41-56 | |
| » Starters: Bob Rush vs Erv Palica | Seventh | 20½ out |
| Friday, July 30 |
| » Lost to Pirates (32-68), 8-6 | Forbes Field (3-2) | 41-57 | |
| » Starters: Paul Minner vs Paul LaPalme | Seventh | 21 out |
| » Defeated Pirates (32-69), 8-5 | Forbes Field (4-2) | 42-57 | |
| » Starters: Howie Pollet vs Max Surkont | Seventh | 21 out |
| Saturday, July 31 |
| » Lost to Pirates (33-69), 5-3 | Forbes Field (4-3) | 42-58 | |
| » Starters: Warren Hacker vs Jake Thies | Seventh | 22 out |
| Sunday, August 1 |
| » Lost to Pirates (34-69), 2-0 | Forbes Field (4-4) | 42-59 | Lost 2 |
| » Starters: Jim Davis vs Dick Littlefield | Seventh | 23 out |
| » Defeated Pirates (34-70), 12-2 | Forbes Field (5-4) | 43-59 | |
| » Starters: Dave Cole vs Laurin Pepper | Seventh | 23 out |
| Tuesday, August 3 |
| » Lost to Giants (68-37), 7-1 | Polo Grounds V (1-6) | 43-60 | |
| » Starters: Bob Rush vs Ruben Gomez | Seventh | 24 out |
| Wednesday, August 4 |
| » Lost to Giants (69-37), 4-3 | Polo Grounds V (1-7) | 43-61 | Lost 2 |
| » Starters: Paul Minner vs Sal Maglie | Seventh | 25 out |
| » Major-league debuts: Foster Castleman (Giants) |
| Thursday, August 5 |
| » Defeated Giants (69-38), 6-4 | Polo Grounds V (2-7) | 44-61 | |
| » Starters: Warren Hacker vs Jim Hearn | Seventh | 24 out |
| Friday, August 6 |
| » Lost to Phillies (50-52), 7-4 | Shibe Park (0-6) | 44-62 | |
| » Starters: Howie Pollet vs Curt Simmons | Seventh | 24 out |
| Saturday, August 7 |
| » Lost to Phillies (51-52), 8-2 | Shibe Park (0-7) | 44-63 | Lost 2 |
| » Starters: Dave Cole vs Bob Miller | Seventh | 24 out |
| Sunday, August 8 |
| » Lost to Phillies (52-52), 8-4 | Shibe Park (0-8) | 44-64 | Lost 3 |
| » Starters: Paul Minner vs Robin Roberts | Seventh | 24½ out |
| » Lost to Phillies (53-52), 8-3 | Shibe Park (0-9) | 44-65 | Lost 4 |
| » Starters: Bob Rush vs Herm Wehmeier | Seventh | 24½ out |
| Tuesday, August 10 |
| » Lost to Reds (53-58), 2-1 | Crosley Field (2-5) | 44-66 | Lost 5 |
| » Starters: Howie Pollet vs Corky Valentine | Seventh | 25½ out |
| Wednesday, August 11 |
| » Lost to Reds (54-58), 8-1 | Crosley Field (2-6) | 44-67 | Lost 6 |
| » Starters: Warren Hacker vs Art Fowler | Seventh | 26 out |
| Thursday, August 12 |
| » Lost to Reds (55-58), 8-6 | Crosley Field (2-7) | 44-68 | Lost 7 |
| » Starters: Paul Minner vs Bud Podbielan | Seventh | 26½ out |
| Friday, August 13 |
| » Lost to Braves (64-47), 5-2 | County Stadium (3-4) | 44-69 | Lost 8 |
| » Starters: Dave Cole vs Lew Burdette | Seventh | 26½ out |
| Saturday, August 14 |
| » Lost to Braves (65-47), 3-1 | County Stadium (3-5) | 44-70 | Lost 9 |
| » Starters: Bob Rush vs Chet Nichols | Seventh | 26½ out |
| Former Cub Fabian Kowalik dies in Karnes City, TX at the age of 47. |
| Sunday, August 15 |
| » Lost to Braves (66-47), 2-1 | County Stadium (3-6) | 44-71 | Lost 10 |
| » Starters: Johnny Klippstein vs Gene Conley | Seventh | 26½ out |
| Tuesday, August 17 |
| » Defeated Reds (56-61), 5-0 | Wrigley Field (25-29) | 45-71 | |
| » Starters: Corky Valentine vs Howie Pollet | Seventh | 26 out |
| » Defeated Reds (56-62), 6-1 | Wrigley Field (26-29) | 46-71 | Won 2 |
| » Starters: Bud Podbielan vs Paul Minner | Seventh | 26 out |
| Thursday, August 19 |
| » Lost to Reds (57-62), 7-0 | Wrigley Field (26-30) | 46-72 | |
| » Starters: Karl Drews vs Jim Davis | Seventh | 28 out |
| » Lost to Reds (58-62), 6-3 | Wrigley Field (26-31) | 46-73 | Lost 2 |
| » Starters: Art Fowler vs Dave Cole | Seventh | 28 out |
| Friday, August 20 |
| » Defeated Braves (67-50), 3-1 | Wrigley Field (27-31) | 47-73 | |
| » Starters: Gene Conley vs Bob Rush | Seventh | 28 out |
| Saturday, August 21 |
| » Defeated Braves (67-51), 5-2 | Wrigley Field (28-31) | 48-73 | Won 2 |
| » Starters: Chet Nichols vs Johnny Klippstein | Seventh | 27½ out |
| Sunday, August 22 |
| » Lost to Braves (68-51), 12-6 | Wrigley Field (28-32) | 48-74 | |
| » Starters: Jim Wilson vs Dave Cole | Seventh | 29 out |
| Tuesday, August 24 |
| » Lost to Giants (77-44), 5-1 | Wrigley Field (28-33) | 48-75 | Lost 2 |
| » Starters: Ruben Gomez vs Paul Minner | Seventh | 30 out |
| Thursday, August 26 |
| » Defeated Giants (77-45), 4-3 | Wrigley Field (29-33) | 49-75 | |
| » Starters: Don Liddle vs Howie Pollet | Seventh | 30 out |
| » Lost to Giants (78-45), 2-1 | Wrigley Field (29-34) | 49-76 | |
| » Starters: Johnny Antonelli vs Bob Rush | Seventh | 30 out |
| Friday, August 27 |
| » Defeated Phillies (58-65), 4-3 | Wrigley Field (30-34) | 50-76 | |
| » Starters: Murry Dickson vs Johnny Klippstein | Seventh | 30 out |
| Saturday, August 28 |
| » Defeated Phillies (58-66), 5-2 | Wrigley Field (31-34) | 51-76 | Won 2 |
| » Starters: Steve Ridzik vs Dave Cole | Seventh | 29 out |
| Sunday, August 29 |
| » Defeated Pirates (46-83), 7-4 | Wrigley Field (32-34) | 52-76 | Won 3 |
| » Starters: Dick Littlefield vs Paul Minner | Seventh | 28 out |
| » Defeated Pirates (46-84), 4-1 | Wrigley Field (33-34) | 53-76 | Won 4 |
| » Starters: Johnny Hetki vs Jim Davis | Seventh | 28 out |
| Tuesday, August 31 |
| » Defeated Pirates (46-85), 14-2 | Wrigley Field (34-34) | 54-76 | Won 5 |
| » Starters: Laurin Pepper vs Howie Pollet | Seventh | 28 out |
| » Defeated Pirates (46-86), 7-3 | Wrigley Field (35-34) | 55-76 | Won 6 |
| » Starters: Jake Thies vs Bob Rush | Seventh | 28 out |
| Wednesday, September 1 |
| » Defeated Dodgers (79-52), 9-5 | Wrigley Field (36-34) | 56-76 | Won 7 |
| » Starters: Johnny Podres vs Warren Hacker | Seventh | 27 out |
| Thursday, September 2 |
| » Lost to Dodgers (80-52), 10-2 | Wrigley Field (36-35) | 56-77 | |
| » Starters: Russ Meyer vs Dave Cole | Seventh | 27½ out |
| Friday, September 3 |
| » Defeated Cardinals (60-72), 4-3 | Sportsman's Park III (6-3) | 57-77 | |
| » Starters: Paul Minner vs Gordon Jones | Seventh | 27½ out |
| Saturday, September 4 |
| » Defeated Cardinals (60-73), 6-5 | Sportsman's Park III (7-3) | 58-77 | Won 2 |
| » Starters: Bob Rush vs Vic Raschi | Seventh | 27½ out |
| Sunday, September 5 |
| » Lost to Cardinals (61-73), 6-2 | Sportsman's Park III (7-4) | 58-78 | |
| » Starters: Howie Pollet vs Brooks Lawrence | Seventh | 27½ out |
| Monday, September 6 |
| » Lost to Braves (80-54), 13-2 | County Stadium (3-7) | 58-79 | Lost 2 |
| » Starters: Johnny Klippstein vs Ernie Johnson | Seventh | 28½ out |
| » Lost to Braves (81-54), 6-1 | County Stadium (3-8) | 58-80 | Lost 3 |
| » Starters: Dave Cole vs Lew Burdette | Seventh | 28½ out |
| » Major-league debuts: Al Lary (Cubs) |
| Thursday, September 9 |
| » Lost to Giants (87-50), 7-6 | Polo Grounds V (2-8) | 58-81 | Lost 4 |
| » Starters: Paul Minner vs Sal Maglie | Seventh | 29 out |
| » Defeated Giants (87-51), 3-0 | Polo Grounds V (3-8) | 59-81 | |
| » Starters: Bob Rush vs Johnny Antonelli | Seventh | 29 out |
| Saturday, September 11 |
| » Lost to Phillies (66-72), 3-0 | Shibe Park (0-10) | 59-82 | |
| » Starters: Jim Davis vs Herm Wehmeier | Seventh | 30 out |
| » Lost to Phillies (67-72), 8-2 | Shibe Park (0-11) | 59-83 | Lost 2 |
| » Starters: Howie Pollet vs Bob Miller | Seventh | 30 out |
| » Major-league debuts: Jim Fanning (Cubs) |
| Sunday, September 12 |
| » Lost to Dodgers (85-57), 4-2 | Ebbets Field (3-7) | 59-84 | Lost 3 |
| » Starters: Hal Jeffcoat vs Carl Erskine | Seventh | 30½ out |
| » Lost to Dodgers (86-57), 4-3 | Ebbets Field (3-8) | 59-85 | Lost 4 |
| » Starters: Johnny Klippstein vs Russ Meyer | Seventh | 30½ out |
| Tuesday, September 14 |
| » Defeated Pirates (50-95), 9-2 | Forbes Field (6-4) | 60-85 | |
| » Starters: Bob Rush vs Jake Thies | Seventh | 31½ out |
| » Lost to Pirates (51-95), 4-0 | Forbes Field (6-5) | 60-86 | |
| » Starters: Paul Minner vs Bob Friend | Seventh | 31½ out |
| Saturday, September 18 |
| » Lost to Reds (71-76), 5-1 | Crosley Field (2-8) | 60-87 | Lost 2 |
| » Starters: Howie Pollet vs Corky Valentine | Seventh | 33 out |
| Sunday, September 19 |
| » Lost to Reds (72-76), 7-6 | Crosley Field (2-9) | 60-88 | Lost 3 |
| » Starters: Dave Cole vs Art Fowler | Sixth | 33½ out |
| Monday, September 20 |
| » Lost to Cardinals (70-77), 7-2 | Wrigley Field (36-36) | 60-89 | Lost 4 |
| » Starters: Tom Poholsky vs Paul Minner | Seventh | 34½ out |
| Tuesday, September 21 |
| » Defeated Cardinals (70-78), 4-3 | Wrigley Field (37-36) | 61-89 | |
| » Starters: Vic Raschi vs Bob Rush | Seventh | 34 out |
| » Defeated Cardinals (70-79), 3-2 | Wrigley Field (38-36) | 62-89 | Won 2 |
| » Starters: Harvey Haddix vs Johnny Klippstein | Seventh | 34 out |
| Wednesday, September 22 |
| » Lost to Cardinals (71-79), 6-3 | Wrigley Field (38-37) | 62-90 | |
| » Starters: Brooks Lawrence vs Dave Cole | Seventh | 34 out |
| Saturday, September 25 |
| » Defeated Reds (74-79), 4-2 | Wrigley Field (39-37) | 63-90 | |
| » Starters: Art Fowler vs Al Lary | Seventh | 33 out |
| Sunday, September 26 |
| » Defeated Reds (74-80), 5-2 | Wrigley Field (40-37) | 64-90 | Won 2 |
| » Starters: Joe Nuxhall vs Bob Rush | Seventh | 33 out |
| Sunday, October 3 |
| Future Cub Dennis Eckersley is born in Oakland, CA. |
| Wednesday, October 13 |
| Future Cub George Frazier is born in Oklahoma City, OK. |
| Tuesday, October 19 |
| Former Cub Hugh Duffy dies in Boston, MA at the age of 88. |
| Friday, October 22 |
| Former Cub Earl Whitehill dies in Omaha, NE at the age of 55. |
| Sunday, November 14 |
| Future Cub Willie Hernandez is born in Aguada, P.R. |
| Sunday, November 21 |
| Future Cub Alan Hargesheimer is born in Chicago, IL. Former Cub Uel Eubanks dies in Dallas, TX at the age of 52. |
| Sunday, December 19 |
| Former Cub Big Jeff Pfeffer dies in Kankakee, IL at the age of 73. |
Game information provided by Retrosheet (www.retrosheet.org) |