| Thursday, January 1 |
| Former White Sox Doug McWeeny dies in Melrose Park, IL at the age of 57. |
| Saturday, January 24 |
| Future White Sox Tim Stoddard is born in East Chicago, IN. |
| Sunday, January 25 |
| Future White Sox Junior Moore is born in Waskom, TX. |
| Tuesday, January 27 |
| Former White Sox Merv Shea dies in Sacramento, CA at the age of 53. |
| Friday, February 13 |
| Former White Sox Happy Foreman dies in New York, NY at the age of 56. |
| Friday, February 27 |
| Future White Sox Ron Hassey is born in Tucson, AZ. |
| Monday, April 13 |
| » Major-league debuts: Bill Bruton (Braves) |
| Tuesday, April 14 |
| » Lost to Indians (1-0), 6-0 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Saul Rogovin vs Bob Lemon | Third | 1 out |
| Former White Sox Roy Patterson dies in St.Croix Falls, WI at the age of 77. |
| Thursday, April 16 |
| » Defeated Browns (1-1), 1-0 | Comiskey Park I (1-0) | 1-1 | |
| » Starters: Harry Brecheen vs Billy Pierce | Fourth | 1 out |
| Friday, April 17 |
| » Lost to Browns (2-1), 6-4 | Comiskey Park I (1-1) | 1-2 | |
| » Starters: Dick Littlefield vs Joe Dobson | Fifth | 1½ out |
| » Major-league debuts: Connie Johnson (White Sox) |
| Saturday, April 18 |
| » Defeated Indians (2-2), 7-6 | Comiskey Park I (2-1) | 2-2 | |
| » Starters: Early Wynn vs Tommy Byrne | Fourth | 1½ out |
| » Major-league debuts: Dave Hoskins (Indians) |
| Tuesday, April 21 |
| » Defeated Tigers (1-6), 7-5 | Tiger Stadium (1-0) | 3-2 | Won 2 |
| » Starters: Billy Pierce vs Ray Herbert | Second | 1 out |
| » Major-league debuts: Paul Foytack (Tigers) |
| Wednesday, April 22 |
| » Defeated Tigers (1-7), 9-7 | Tiger Stadium (2-0) | 4-2 | Won 3 |
| » Starters: Joe Dobson vs Milt Jordan | Third | 1 out |
| Thursday, April 23 |
| » Lost to Tigers (2-7), 8-4 | Tiger Stadium (2-1) | 4-3 | |
| » Starters: Saul Rogovin vs Billy Hoeft | Fourth | 2 out |
| Friday, April 24 |
| » Defeated Browns (5-3), 3-0 | Sportsman's Park III (1-0) | 5-3 | |
| » Starters: Lou Kretlow vs Virgil Trucks | Third | 2 out |
| Saturday, April 25 |
| » Defeated Browns (5-4), 6-4 | Sportsman's Park III (2-0) | 6-3 | Won 2 |
| » Starters: Tommy Byrne vs Duane Pillette | Third | 2 out |
| Sunday, April 26 |
| » Lost to Browns (6-4), 7-2 | Sportsman's Park III (2-1) | 6-4 | |
| » Starters: Billy Pierce vs Dick Littlefield | Third | 1 out |
| » Defeated Browns (6-5), 3-0 | Sportsman's Park III (3-1) | 7-4 | |
| » Starters: Joe Dobson vs Mike Blyzka | Third | 1 out |
| Tuesday, April 28 |
| » Defeated Senators (3-9), 5-4 | Comiskey Park I (3-1) | 8-4 | Won 2 |
| » Starters: Walt Masterson vs Connie Johnson | Third | 1½ out |
| Wednesday, April 29 |
| » Lost to Senators (4-9), 3-0 | Comiskey Park I (3-2) | 8-5 | |
| » Starters: Bob Porterfield vs Saul Rogovin | Third | 2 out |
| Thursday, April 30 |
| » Lost to Yankees (11-3), 6-1 | Comiskey Park I (3-3) | 8-6 | Lost 2 |
| » Starters: Whitey Ford vs Gene Bearden | Third | 3 out |
| Friday, May 1 |
| » Defeated Yankees (11-4), 6-5 | Comiskey Park I (4-3) | 9-6 | |
| » Starters: Johnny Sain vs Billy Pierce | Third | 2 out |
| Saturday, May 2 |
| » Defeated Yankees (11-5), 8-7 | Comiskey Park I (5-3) | 10-6 | Won 2 |
| » Starters: Eddie Lopat vs Tommy Byrne | Second | 1 out |
| Sunday, May 3 |
| » Lost to Athletics (9-7), 4-2 | Comiskey Park I (5-4) | 10-7 | |
| » Starters: Bobby Shantz vs Joe Dobson | Fifth | 2½ out |
| » Lost to Athletics (10-7), 10-6 | Comiskey Park I (5-5) | 10-8 | Lost 2 |
| » Starters: Alex Kellner vs Connie Johnson | Fifth | 2½ out |
| Tuesday, May 5 |
| » Lost to Red Sox (10-7), 5-1 | Comiskey Park I (5-6) | 10-9 | Lost 3 |
| » Starters: Mel Parnell vs Saul Rogovin | Fifth | 3 out |
| Wednesday, May 6 |
| » Defeated Red Sox (10-8), 6-2 | Comiskey Park I (6-6) | 11-9 | |
| » Starters: Marv Grissom vs Billy Pierce | Fourth | 2½ out |
| Friday, May 8 |
| » Defeated Tigers (5-17), 7-2 | Comiskey Park I (7-6) | 12-9 | Won 2 |
| » Starters: Ted Gray vs Joe Dobson | Fourth | 1½ out |
| Saturday, May 9 |
| » Defeated Tigers (5-18), 12-3 | Comiskey Park I (8-6) | 13-9 | Won 3 |
| » Starters: Art Houtteman vs Mike Fornieles | Third | 1½ out |
| Sunday, May 10 |
| » Lost to Tigers (6-18), 8-6 | Comiskey Park I (8-7) | 13-10 | |
| » Starters: Billy Hoeft vs Gene Bearden | Third | 2½ out |
| » Defeated Tigers (6-19), 10-5 | Comiskey Park I (9-7) | 14-10 | |
| » Starters: Bill Wight vs Saul Rogovin | Third | 2½ out |
| Monday, May 11 |
| » Defeated Indians (13-7), 2-1 | Cleveland Stadium (1-1) | 15-10 | Won 2 |
| » Starters: Billy Pierce vs Bob Lemon | Third | 1½ out |
| Tuesday, May 12 |
| » Defeated Red Sox (11-11), 9-7 | Fenway Park (1-0) | 16-10 | Won 3 |
| » Starters: Lou Kretlow vs Mel Parnell | Third | 1½ out |
| Wednesday, May 13 |
| » Lost to Red Sox (12-11), 3-0 | Fenway Park (1-1) | 16-11 | |
| » Starters: Joe Dobson vs Marv Grissom | Second | 2½ out |
| Thursday, May 14 |
| » Defeated Yankees (17-8), 7-5 | Yankee Stadium (1-0) | 17-11 | |
| » Starters: Tommy Byrne vs Johnny Sain | Second | 1½ out |
| Saturday, May 16 |
| » Defeated Yankees (17-9), 5-3 | Yankee Stadium (2-0) | 18-11 | Won 2 |
| » Starters: Billy Pierce vs Vic Raschi | Second | 1½ out |
| Sunday, May 17 |
| » Defeated Senators (14-15), 7-3 | Griffith Stadium (1-0) | 19-11 | Won 3 |
| » Starters: Saul Rogovin vs Chuck Stobbs | Second | 1½ out |
| Monday, May 18 |
| » Lost to Senators (15-15), 3-0 | Griffith Stadium (1-1) | 19-12 | |
| » Starters: Joe Dobson vs Connie Marrero | Second | 2 out |
| Tuesday, May 19 |
| » Lost to Athletics (13-18), 2-1 | Shibe Park (0-1) | 19-13 | Lost 2 |
| » Starters: Mike Fornieles vs Harry Byrd | Second | 2 out |
| Wednesday, May 20 |
| » Lost to Athletics (14-18), 2-1 | Shibe Park (0-2) | 19-14 | Lost 3 |
| » Starters: Billy Pierce vs Morrie Martin | Third | 3 out |
| Friday, May 22 |
| » Lost to Tigers (10-24), 7-0 | Tiger Stadium (2-2) | 19-15 | Lost 4 |
| » Starters: Saul Rogovin vs Art Houtteman | Third | 3½ out |
| Saturday, May 23 |
| » Defeated Tigers (10-25), 4-2 | Tiger Stadium (3-2) | 20-15 | |
| » Starters: Joe Dobson vs Ned Garver | Third | 3½ out |
| Sunday, May 24 |
| » Defeated Tigers (10-26), 3-1 | Tiger Stadium (4-2) | 21-15 | Won 2 |
| » Starters: Mike Fornieles vs Ted Gray | Third | 3½ out |
| » Major-league debuts: Bob Keegan (White Sox) |
| Monday, May 25 |
| » Defeated Browns (12-22), 7-5 | Sportsman's Park III (4-1) | 22-15 | Won 3 |
| » Starters: Billy Pierce vs Virgil Trucks | Third | 2½ out |
| Tuesday, May 26 |
| » Defeated Browns (12-23), 8-2 | Sportsman's Park III (5-1) | 23-15 | Won 4 |
| » Starters: Tommy Byrne vs Duane Pillette | Third | 2 out |
| Wednesday, May 27 |
| » Tied Tigers, 2-2 | Comiskey Park I (9-7) | 23-15 | |
| » Starters: Art Houtteman vs Joe Dobson | Second | 2½ out |
| Friday, May 29 |
| » Lost to Indians (20-14), 2-1 | Comiskey Park I (9-8) | 23-16 | |
| » Starters: Mike Garcia vs Bob Keegan | Second | 4 out |
| Saturday, May 30 |
| » Lost to Indians (21-14), 7-2 | Comiskey Park I (9-9) | 23-17 | Lost 2 |
| » Starters: Bob Feller vs Billy Pierce | Second | 4 out |
| » Defeated Indians (21-15), 6-5 | Comiskey Park I (10-9) | 24-17 | |
| » Starters: Early Wynn vs Lou Kretlow | Second | 4 out |
| Sunday, May 31 |
| » Defeated Browns (17-24), 7-4 | Comiskey Park I (11-9) | 25-17 | Won 2 |
| » Starters: Bobo Holloman vs Tommy Byrne | Third | 4½ out |
| » Lost to Browns (18-24), 7-4 | Comiskey Park I (11-10) | 25-18 | |
| » Starters: Mike Blyzka vs Saul Rogovin | Third | 4½ out |
| Tuesday, June 2 |
| » Lost to Yankees (28-11), 4-3 | Comiskey Park I (11-11) | 25-19 | Lost 2 |
| » Starters: Eddie Lopat vs Mike Fornieles | Third | 5½ out |
| Wednesday, June 3 |
| » Lost to Yankees (29-11), 18-2 | Comiskey Park I (11-12) | 25-20 | Lost 3 |
| » Starters: Whitey Ford vs Bob Keegan | Third | 6½ out |
| Thursday, June 4 |
| » Lost to Yankees (30-11), 9-5 | Comiskey Park I (11-13) | 25-21 | Lost 4 |
| » Starters: Vic Raschi vs Billy Pierce | Third | 7½ out |
| Friday, June 5 |
| » Lost to Senators (26-21), 8-4 | Comiskey Park I (11-14) | 25-22 | Lost 5 |
| » Starters: Connie Marrero vs Saul Rogovin | Fourth | 8½ out |
| Saturday, June 6 |
| Former White Sox Bill Burns dies in Ramona, CA at the age of 74. |
| Sunday, June 7 |
| » Lost to Senators (27-21), 16-2 | Comiskey Park I (11-15) | 25-23 | Lost 6 |
| » Starters: Bob Porterfield vs Mike Fornieles | Fourth | 10 out |
| » Defeated Senators (27-22), 5-1 | Comiskey Park I (12-15) | 26-23 | |
| » Starters: Spec Shea vs Fritz Dorish | Fourth | 10 out |
| Monday, June 8 |
| Future White Sox Jack Kucek is born in Warren, OH. |
| Tuesday, June 9 |
| » Defeated Athletics (21-29), 5-1 | Comiskey Park I (13-15) | 27-23 | Won 2 |
| » Starters: Marion Fricano vs Billy Pierce | Third | 10 out |
| Wednesday, June 10 |
| » Lost to Athletics (22-29), 2-1 | Comiskey Park I (13-16) | 27-24 | |
| » Starters: Harry Byrd vs Sandy Consuegra | Fourth | 11 out |
| Future White Sox Francisco Barrios is born in Hermosillo, Mexico. |
| Thursday, June 11 |
| » Lost to Athletics (23-29), 6-5 | Comiskey Park I (13-17) | 27-25 | Lost 2 |
| » Starters: Charlie Bishop vs Joe Dobson | Fifth | 12 out |
| Friday, June 12 |
| » Lost to Red Sox (30-24), 4-3 | Comiskey Park I (13-18) | 27-26 | Lost 3 |
| » Starters: Hal Brown vs Saul Rogovin | Fifth | 13 out |
| Saturday, June 13 |
| » Defeated Red Sox (30-25), 5-2 | Comiskey Park I (14-18) | 28-26 | |
| » Starters: Mickey McDermott vs Mike Fornieles | Fourth | 13 out |
| Sunday, June 14 |
| » Defeated Red Sox (30-26), 6-0 | Comiskey Park I (15-18) | 29-26 | Won 2 |
| » Starters: Marv Grissom vs Billy Pierce | Third | 13 out |
| » Defeated Red Sox (30-27), 1-0 | Comiskey Park I (16-18) | 30-26 | Won 3 |
| » Starters: Mel Parnell vs Sandy Consuegra | Third | 13 out |
| Tuesday, June 16 |
| » Defeated Senators (29-27), 7-3 | Griffith Stadium (2-1) | 31-26 | Won 4 |
| » Starters: Fritz Dorish vs Johnny Schmitz | Third | 12 out |
| Wednesday, June 17 |
| » Lost to Senators (30-27), 1-0 | Griffith Stadium (2-2) | 31-27 | |
| » Starters: Saul Rogovin vs Walt Masterson | Third | 13 out |
| Thursday, June 18 |
| » Defeated Senators (30-28), 8-4 | Griffith Stadium (3-2) | 32-27 | |
| » Starters: Virgil Trucks vs Connie Marrero | Third | 13½ out |
| Friday, June 19 |
| » Defeated Athletics (28-32), 5-2 | Shibe Park (1-2) | 33-27 | Won 2 |
| » Starters: Sandy Consuegra vs Marion Fricano | Third | 12½ out |
| Saturday, June 20 |
| » Defeated Athletics (28-33), 6-4 | Shibe Park (2-2) | 34-27 | Won 3 |
| » Starters: Billy Pierce vs Charlie Bishop | Third | 12½ out |
| Sunday, June 21 |
| » Lost to Athletics (29-33), 5-0 | Shibe Park (2-3) | 34-28 | |
| » Starters: Joe Dobson vs Harry Byrd | Third | 12½ out |
| » Defeated Athletics (29-34), 9-4 | Shibe Park (3-3) | 35-28 | |
| » Starters: Bob Keegan vs Carl Scheib | Third | 12½ out |
| Tuesday, June 23 |
| » Defeated Yankees (46-15), 11-3 | Yankee Stadium (3-0) | 36-28 | Won 2 |
| » Starters: Virgil Trucks vs Allie Reynolds | Third | 11½ out |
| Wednesday, June 24 |
| » Defeated Yankees (46-16), 8-4 | Yankee Stadium (4-0) | 37-28 | Won 3 |
| » Starters: Saul Rogovin vs Jim McDonald | Third | 10½ out |
| Thursday, June 25 |
| » Defeated Yankees (46-17), 4-2 | Yankee Stadium (5-0) | 38-28 | Won 4 |
| » Starters: Billy Pierce vs Johnny Sain | Third | 9½ out |
| Friday, June 26 |
| » Defeated Red Sox (37-32), 5-3 | Fenway Park (2-1) | 39-28 | Won 5 |
| » Starters: Sandy Consuegra vs Hal Brown | Third | 8½ out |
| Saturday, June 27 |
| » Defeated Red Sox (37-33), 6-5 | Fenway Park (3-1) | 40-28 | Won 6 |
| » Starters: Bob Keegan vs Sid Hudson | Third | 7½ out |
| Sunday, June 28 |
| » Defeated Red Sox (37-34), 13-4 | Fenway Park (4-1) | 41-28 | Won 7 |
| » Starters: Virgil Trucks vs Willard Nixon | Third | 6½ out |
| Tuesday, June 30 |
| » Lost to Browns (27-46), 4-2 | Comiskey Park I (16-19) | 41-29 | |
| » Starters: Bob Cain vs Billy Pierce | Third | 6½ out |
| Wednesday, July 1 |
| » Defeated Browns (27-47), 13-4 | Comiskey Park I (17-19) | 42-29 | |
| » Starters: Dick Littlefield vs Saul Rogovin | Third | 5½ out |
| Friday, July 3 |
| Future White Sox John Verhoeven is born in Long Beach, CA. |
| Saturday, July 4 |
| » Defeated Browns (27-48), 13-0 | Sportsman's Park III (6-1) | 43-29 | Won 2 |
| » Starters: Virgil Trucks vs Duane Pillette | Second | 6½ out |
| » Defeated Browns (27-49), 4-2 | Sportsman's Park III (7-1) | 44-29 | Won 3 |
| » Starters: Joe Dobson vs Harry Brecheen | Second | 6½ out |
| Sunday, July 5 |
| » Lost to Indians (44-29), 7-6 | Cleveland Stadium (1-2) | 44-30 | |
| » Starters: Sandy Consuegra vs Bob Lemon | Second | 5½ out |
| » Defeated Indians (44-30), 4-0 | Cleveland Stadium (2-2) | 45-30 | |
| » Starters: Billy Pierce vs Bob Chakales | Second | 5½ out |
| Monday, July 6 |
| » Lost to Indians (45-30), 6-3 | Cleveland Stadium (2-3) | 45-31 | |
| » Starters: Saul Rogovin vs Mike Garcia | Third | 7 out |
| Tuesday, July 7 |
| » Defeated Tigers (26-52), 3-2 | Comiskey Park I (18-19) | 46-31 | |
| » Starters: Billy Hoeft vs Mike Fornieles | Third | 6 out |
| Wednesday, July 8 |
| » Defeated Tigers (26-53), 14-4 | Comiskey Park I (19-19) | 47-31 | Won 2 |
| » Starters: Ned Garver vs Virgil Trucks | Second | 6 out |
| Thursday, July 9 |
| » Defeated Tigers (26-54), 4-2 | Comiskey Park I (20-19) | 48-31 | Won 3 |
| » Starters: Dick Marlowe vs Joe Dobson | Second | 5 out |
| Friday, July 10 |
| » Lost to Indians (48-31), 3-0 | Comiskey Park I (20-20) | 48-32 | |
| » Starters: Bob Feller vs Billy Pierce | Second | 5½ out |
| » Defeated Indians (48-32), 16-5 | Comiskey Park I (21-20) | 49-32 | |
| » Starters: Mike Garcia vs Gene Bearden | Second | 5½ out |
| » Major-league debuts: Al Smith (Indians) |
| Saturday, July 11 |
| » Defeated Indians (48-33), 5-4 | Comiskey Park I (22-20) | 50-32 | Won 2 |
| » Starters: Early Wynn vs Joe Dobson | Second | 5½ out |
| Sunday, July 12 |
| » Defeated Indians (48-34), 14-2 | Comiskey Park I (23-20) | 51-32 | Won 3 |
| » Starters: Art Houtteman vs Mike Fornieles | Second | 5 out |
| » Defeated Indians (48-35), 3-1 | Comiskey Park I (24-20) | 52-32 | Won 4 |
| » Starters: Bob Lemon vs Virgil Trucks | Second | 5 out |
| Thursday, July 16 |
| » Defeated Senators (42-43), 6-5 | Comiskey Park I (25-20) | 53-32 | Won 5 |
| » Starters: Spec Shea vs Sandy Consuegra | Second | 4 out |
| » Defeated Senators (42-44), 5-4 | Comiskey Park I (26-20) | 54-32 | Won 6 |
| » Starters: Bob Porterfield vs Fritz Dorish | Second | 4 out |
| Friday, July 17 |
| » Defeated Senators (42-45), 4-1 | Comiskey Park I (27-20) | 55-32 | Won 7 |
| » Starters: Connie Marrero vs Virgil Trucks | Second | 4 out |
| Saturday, July 18 |
| » Defeated Senators (42-46), 10-6 | Comiskey Park I (28-20) | 56-32 | Won 8 |
| » Starters: Johnny Schmitz vs Saul Rogovin | Second | 4 out |
| Sunday, July 19 |
| » Lost to Yankees (60-27), 6-2 | Comiskey Park I (28-21) | 56-33 | |
| » Starters: Eddie Lopat vs Mike Fornieles | Second | 6 out |
| » Lost to Yankees (61-27), 3-0 | Comiskey Park I (28-22) | 56-34 | Lost 2 |
| » Starters: Vic Raschi vs Billy Pierce | Second | 6 out |
| Wednesday, July 22 |
| » Defeated Red Sox (52-40), 1-0 | Comiskey Park I (29-22) | 57-34 | |
| » Starters: Mel Parnell vs Virgil Trucks | Second | 4½ out |
| Thursday, July 23 |
| » Lost to Red Sox (53-40), 4-3 | Comiskey Park I (29-23) | 57-35 | |
| » Starters: Hal Brown vs Saul Rogovin | Second | 4½ out |
| Friday, July 24 |
| » Lost to Athletics (38-54), 4-2 | Comiskey Park I (29-24) | 57-36 | Lost 2 |
| » Starters: Harry Byrd vs Billy Pierce | Second | 4½ out |
| Saturday, July 25 |
| » Lost to Athletics (39-54), 7-2 | Comiskey Park I (29-25) | 57-37 | Lost 3 |
| » Starters: Alex Kellner vs Mike Fornieles | Second | 5½ out |
| Sunday, July 26 |
| » Lost to Athletics (40-54), 4-3 | Comiskey Park I (29-26) | 57-38 | Lost 4 |
| » Starters: Bobby Shantz vs Sandy Consuegra | Second | 5½ out |
| » Defeated Athletics (40-55), 4-0 | Comiskey Park I (30-26) | 58-38 | |
| » Starters: Charlie Bishop vs Virgil Trucks | Second | 5½ out |
| Tuesday, July 28 |
| » Defeated Red Sox (57-42), 4-2 | Fenway Park (5-1) | 59-38 | Won 2 |
| » Starters: Fritz Dorish vs Hal Brown | Second | 5½ out |
| Wednesday, July 29 |
| » Defeated Red Sox (57-43), 8-3 | Fenway Park (6-1) | 60-38 | Won 3 |
| » Starters: Billy Pierce vs Mickey McDermott | Second | 5½ out |
| Thursday, July 30 |
| » Defeated Red Sox (57-44), 17-1 | Fenway Park (7-1) | 61-38 | Won 4 |
| » Starters: Mike Fornieles vs Mel Parnell | Second | 4½ out |
| Friday, July 31 |
| » Lost to Senators (48-53), 2-0 | Griffith Stadium (3-3) | 61-39 | |
| » Starters: Virgil Trucks vs Bob Porterfield | Second | 5½ out |
| Saturday, August 1 |
| » Defeated Senators (48-54), 4-0 | Griffith Stadium (4-3) | 62-39 | |
| » Starters: Connie Johnson vs Spec Shea | Second | 4½ out |
| » Major-league debuts: Yo-Yo Davalillo (Senators) |
| Sunday, August 2 |
| » Lost to Senators (49-54), 1-0 | Griffith Stadium (4-4) | 62-40 | |
| » Starters: Fritz Dorish vs Walt Masterson | Second | 5 out |
| Monday, August 3 |
| » Defeated Senators (49-55), 1-0 | Griffith Stadium (5-4) | 63-40 | |
| » Starters: Billy Pierce vs Johnny Schmitz | Second | 5 out |
| Tuesday, August 4 |
| » Defeated Athletics (43-60), 8-3 | Shibe Park (4-3) | 64-40 | Won 2 |
| » Starters: Virgil Trucks vs Harry Byrd | Second | 5 out |
| Wednesday, August 5 |
| » Defeated Athletics (43-61), 9-7 | Shibe Park (5-3) | 65-40 | Won 3 |
| » Starters: Joe Dobson vs Marion Fricano | Second | 5 out |
| Thursday, August 6 |
| » Defeated Athletics (43-62), 6-4 | Shibe Park (6-3) | 66-40 | Won 4 |
| » Starters: Mike Fornieles vs Joe Coleman | Second | 5 out |
| Friday, August 7 |
| » Lost to Yankees (71-34), 6-1 | Yankee Stadium (5-1) | 66-41 | |
| » Starters: Connie Johnson vs Eddie Lopat | Second | 6 out |
| Saturday, August 8 |
| » Lost to Yankees (72-34), 1-0 | Yankee Stadium (5-2) | 66-42 | Lost 2 |
| » Starters: Sandy Consuegra vs Whitey Ford | Second | 8 out |
| » Lost to Yankees (73-34), 3-0 | Yankee Stadium (5-3) | 66-43 | Lost 3 |
| » Starters: Virgil Trucks vs Bob Kuzava | Second | 8 out |
| Sunday, August 9 |
| » Defeated Yankees (73-35), 5-0 | Yankee Stadium (6-3) | 67-43 | |
| » Starters: Billy Pierce vs Vic Raschi | Second | 7 out |
| Tuesday, August 11 |
| » Defeated Indians (62-47), 6-2 | Cleveland Stadium (3-3) | 68-43 | Won 2 |
| » Starters: Connie Johnson vs Bob Lemon | Second | 6 out |
| Wednesday, August 12 |
| » Lost to Indians (63-47), 7-4 | Cleveland Stadium (3-4) | 68-44 | |
| » Starters: Mike Fornieles vs Early Wynn | Second | 7 out |
| Thursday, August 13 |
| » Defeated Indians (63-48), 7-3 | Cleveland Stadium (4-4) | 69-44 | |
| » Starters: Virgil Trucks vs Mike Garcia | Second | 7 out |
| Friday, August 14 |
| » Defeated Tigers (40-73), 7-0 | Tiger Stadium (5-2) | 70-44 | Won 2 |
| » Starters: Billy Pierce vs Billy Hoeft | Second | 6½ out |
| Saturday, August 15 |
| » Lost to Tigers (41-73), 5-4 | Tiger Stadium (5-3) | 70-45 | |
| » Starters: Fritz Dorish vs Ted Gray | Second | 6½ out |
| Sunday, August 16 |
| » Lost to Tigers (42-73), 3-2 | Tiger Stadium (5-4) | 70-46 | Lost 2 |
| » Starters: Connie Johnson vs Ralph Branca | Second | 8 out |
| Tuesday, August 18 |
| » Defeated Browns (41-78), 3-2 | Comiskey Park I (31-26) | 71-46 | |
| » Starters: Lou Kretlow vs Virgil Trucks | Second | 7½ out |
| » Defeated Browns (41-79), 2-1 | Comiskey Park I (32-26) | 72-46 | Won 2 |
| » Starters: Satchel Paige vs Sandy Consuegra | Second | 7½ out |
| Wednesday, August 19 |
| » Lost to Browns (42-79), 4-3 | Comiskey Park I (32-27) | 72-47 | |
| » Starters: Duane Pillette vs Billy Pierce | Second | 8½ out |
| Friday, August 21 |
| » Defeated Tigers (44-75), 4-1 | Comiskey Park I (33-27) | 73-47 | |
| » Starters: Ralph Branca vs Mike Fornieles | Second | 9 out |
| Saturday, August 22 |
| » Lost to Tigers (45-75), 2-1 | Comiskey Park I (33-28) | 73-48 | |
| » Starters: Ned Garver vs Bob Keegan | Second | 9 out |
| Sunday, August 23 |
| » Defeated Tigers (45-76), 2-1 | Comiskey Park I (34-28) | 74-48 | |
| » Starters: Steve Gromek vs Sandy Consuegra | Second | 8½ out |
| » Defeated Tigers (45-77), 11-6 | Comiskey Park I (35-28) | 75-48 | Won 2 |
| » Starters: Al Aber vs Virgil Trucks | Second | 8½ out |
| Tuesday, August 25 |
| » Lost to Athletics (50-73), 4-2 | Comiskey Park I (35-29) | 75-49 | |
| » Starters: Joe Coleman vs Billy Pierce | Second | 9½ out |
| Wednesday, August 26 |
| » Lost to Athletics (51-73), 10-8 | Comiskey Park I (35-30) | 75-50 | Lost 2 |
| » Starters: Alex Kellner vs Mike Fornieles | Second | 10½ out |
| Thursday, August 27 |
| » Defeated Red Sox (70-57), 6-4 | Comiskey Park I (36-30) | 76-50 | |
| » Starters: Sid Hudson vs Virgil Trucks | Second | 9½ out |
| Friday, August 28 |
| » Lost to Red Sox (71-57), 4-3 | Comiskey Park I (36-31) | 76-51 | |
| » Starters: Bill Henry vs Bob Keegan | Second | 9½ out |
| Saturday, August 29 |
| » Defeated Red Sox (71-58), 5-1 | Comiskey Park I (37-31) | 77-51 | |
| » Starters: Mel Parnell vs Connie Johnson | Second | 8½ out |
| Sunday, August 30 |
| » Lost to Yankees (86-42), 10-6 | Comiskey Park I (37-32) | 77-52 | |
| » Starters: Vic Raschi vs Sandy Consuegra | Second | 8½ out |
| » Defeated Yankees (86-43), 1-0 | Comiskey Park I (38-32) | 78-52 | |
| » Starters: Jim McDonald vs Billy Pierce | Second | 8½ out |
| Monday, August 31 |
| Future White Sox Bill Nahorodny is born in Hamtramck, MI. |
| Tuesday, September 1 |
| » Lost to Yankees (87-43), 3-2 | Comiskey Park I (38-33) | 78-53 | |
| » Starters: Whitey Ford vs Virgil Trucks | Second | 9½ out |
| Wednesday, September 2 |
| » Defeated Senators (66-68), 7-3 | Comiskey Park I (39-33) | 79-53 | |
| » Starters: Spec Shea vs Bob Keegan | Second | 9½ out |
| Thursday, September 3 |
| » Lost to Senators (67-68), 5-1 | Comiskey Park I (39-34) | 79-54 | |
| » Starters: Bob Porterfield vs Connie Johnson | Second | 10½ out |
| Friday, September 4 |
| » Tied Indians, 6-6 | Cleveland Stadium (4-4) | 79-54 | |
| » Starters: Billy Pierce vs Mike Garcia | Second | 10½ out |
| Saturday, September 5 |
| » Defeated Indians (79-55), 2-0 | Cleveland Stadium (5-4) | 80-54 | |
| » Starters: Saul Rogovin vs Early Wynn | Second | 10½ out |
| » Lost to Indians (80-55), 4-1 | Cleveland Stadium (5-5) | 80-55 | |
| » Starters: Sandy Consuegra vs Bob Feller | Second | 10½ out |
| Sunday, September 6 |
| » Lost to Indians (81-55), 4-2 | Cleveland Stadium (5-6) | 80-56 | Lost 2 |
| » Starters: Virgil Trucks vs Art Houtteman | Third | 11 out |
| Monday, September 7 |
| » Lost to Tigers (52-86), 6-2 | Tiger Stadium (5-5) | 80-57 | Lost 3 |
| » Starters: Bob Keegan vs Ned Garver | Third | 12 out |
| » Lost to Tigers (53-86), 4-2 | Tiger Stadium (5-6) | 80-58 | Lost 4 |
| » Starters: Mike Fornieles vs Billy Hoeft | Third | 12 out |
| Wednesday, September 9 |
| » Lost to Yankees (91-44), 9-3 | Yankee Stadium (6-4) | 80-59 | Lost 5 |
| » Starters: Billy Pierce vs Whitey Ford | Third | 13 out |
| Thursday, September 10 |
| » Lost to Yankees (92-44), 1-0 | Yankee Stadium (6-5) | 80-60 | Lost 6 |
| » Starters: Sandy Consuegra vs Eddie Lopat | Third | 14 out |
| Friday, September 11 |
| » Defeated Athletics (53-88), 9-4 | Shibe Park (7-3) | 81-60 | |
| » Starters: Virgil Trucks vs Morrie Martin | Third | 13 out |
| Saturday, September 12 |
| » Defeated Athletics (53-89), 6-5 | Shibe Park (8-3) | 82-60 | Won 2 |
| » Starters: Saul Rogovin vs Joe Coleman | Third | 13 out |
| Sunday, September 13 |
| » Lost to Red Sox (79-65), 7-6 | Fenway Park (7-2) | 82-61 | |
| » Starters: Billy Pierce vs Mel Parnell | Third | 14 out |
| Monday, September 14 |
| » Defeated Red Sox (79-66), 10-6 | Fenway Park (8-2) | 83-61 | |
| » Starters: Connie Johnson vs Bill Henry | Third | 14 out |
| Tuesday, September 15 |
| » Defeated Red Sox (79-67), 6-0 | Fenway Park (9-2) | 84-61 | Won 2 |
| » Starters: Bob Keegan vs Mickey McDermott | Third | 13 out |
| Wednesday, September 16 |
| » Lost to Senators (74-71), 4-2 | Griffith Stadium (5-5) | 84-62 | |
| » Starters: Virgil Trucks vs Connie Marrero | Third | 13½ out |
| Future White Sox Chris Knapp is born in Cherry Point, NC. |
| Thursday, September 17 |
| » Lost to Senators (75-71), 3-2 | Griffith Stadium (5-6) | 84-63 | Lost 2 |
| » Starters: Billy Pierce vs Bob Porterfield | Third | 13½ out |
| Sunday, September 20 |
| » Defeated Browns (53-96), 4-0 | Comiskey Park I (40-34) | 85-63 | |
| » Starters: Duane Pillette vs Bob Keegan | Third | 12½ out |
| » Defeated Browns (53-97), 5-2 | Comiskey Park I (41-34) | 86-63 | Won 2 |
| » Starters: Bob Turley vs Virgil Trucks | Third | 12½ out |
| Tuesday, September 22 |
| » Lost to Indians (89-61), 8-3 | Comiskey Park I (41-35) | 86-64 | |
| » Starters: Bob Feller vs Billy Pierce | Third | 13½ out |
| Wednesday, September 23 |
| » Lost to Indians (90-61), 8-3 | Comiskey Park I (41-36) | 86-65 | Lost 2 |
| » Starters: Bob Lemon vs Saul Rogovin | Third | 14½ out |
| Friday, September 25 |
| » Defeated Browns (54-98), 7-2 | Sportsman's Park III (8-1) | 87-65 | |
| » Starters: Bob Keegan vs Bob Turley | Third | 13½ out |
| Saturday, September 26 |
| » Defeated Browns (54-99), 6-3 | Sportsman's Park III (9-1) | 88-65 | Won 2 |
| » Starters: Connie Johnson vs Don Larsen | Third | 12½ out |
| Sunday, September 27 |
| » Defeated Browns (54-100), 2-1 | Sportsman's Park III (10-1) | 89-65 | Won 3 |
| » Starters: Billy Pierce vs Duane Pillette | Third | 11½ out</ |
