| Sunday, February 3 |
| Future Red Sox Fred Lynn is born in Chicago, IL. |
| Tuesday, April 15 |
| » Defeated Senators (0-1), 3-0 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Mel Parnell vs Bob Porterfield | First | -- |
| » Major-league debuts: Ted Lepcio and Faye Throneberry (Red Sox) |
| Wednesday, April 16 |
| » Lost to Senators (1-1), 4-3 | Griffith Stadium (1-1) | 1-1 | |
| » Starters: Randy Gumpert vs Julio Moreno | Third | 1 out |
| » Major-league debuts: Dick Gernert and Gene Stephens (Red Sox) |
| Thursday, April 17 |
| » Defeated Senators (1-2), 9-2 | Griffith Stadium (2-1) | 2-1 | |
| » Starters: Bill Henry vs Don Johnson | Second | 1 out |
| » Major-league debuts: Raul Sanchez (Senators) Ike Delock and Bill Henry (Red Sox) |
| Friday, April 18 |
| » Defeated Athletics (1-2), 5-4 | Fenway Park (1-0) | 3-1 | Won 2 |
| » Starters: Bob Hooper vs Ray Scarborough | Second | 1 out |
| Saturday, April 19 |
| » Defeated Athletics (1-3), 11-2 | Fenway Park (2-0) | 4-1 | Won 3 |
| » Starters: Dick Fowler vs Harry Taylor | Second | ½ out |
| » Defeated Athletics (1-4), 6-1 | Fenway Park (3-0) | 5-1 | Won 4 |
| » Starters: Morrie Martin vs Mickey McDermott | Second | ½ out |
| » Major-league debuts: Skeeter Kell (Athletics) |
| Sunday, April 20 |
| » Defeated Senators (3-3), 6-3 | Fenway Park (4-0) | 6-1 | Won 5 |
| » Starters: Sid Hudson vs Mel Parnell | Second | 1 out |
| Monday, April 21 |
| » Lost to Senators (4-3), 3-2 | Fenway Park (4-1) | 6-2 | |
| » Starters: Julio Moreno vs James Atkins | Second | 1½ out |
| Tuesday, April 22 |
| » Defeated Senators (4-4), 10-5 | Fenway Park (5-1) | 7-2 | |
| » Starters: Joe Haynes vs Bill Henry | Second | ½ out |
| Wednesday, April 23 |
| » Defeated Yankees (4-4), 3-1 | Fenway Park (6-1) | 8-2 | Won 2 |
| » Starters: Allie Reynolds vs Ellis Kinder | First | -- |
| Thursday, April 24 |
| » Defeated Yankees (4-5), 3-2 | Fenway Park (7-1) | 9-2 | Won 3 |
| » Starters: Ed Lopat vs Mickey McDermott | First | -- |
| Wednesday, April 30 |
| » Defeated Tigers (2-9), 5-3 | Fenway Park (8-1) | 10-2 | Won 4 |
| » Starters: Virgil Trucks vs Mel Parnell | First | -- |
| Thursday, May 1 |
| » Lost to Browns (9-6), 6-1 | Fenway Park (8-2) | 10-3 | |
| » Starters: Duane Pillette vs Walt Masterson | First | -- |
| Friday, May 2 |
| » Defeated Browns (9-7), 13-6 | Fenway Park (9-2) | 11-3 | |
| » Starters: Ned Garver vs Bill Henry | First | -- |
| Saturday, May 3 |
| » Defeated Browns (9-8), 5-2 | Fenway Park (10-2) | 12-3 | Won 2 |
| » Starters: Earl Harrist vs Ellis Kinder | First | -- |
| Sunday, May 4 |
| » Lost to Indians (11-7), 9-6 | Fenway Park (10-3) | 12-4 | |
| » Starters: Early Wynn vs Mickey McDermott | First | -- |
| Monday, May 5 |
| » Lost to Indians (12-7), 4-2 | Fenway Park (10-4) | 12-5 | Lost 2 |
| » Starters: Bob Lemon vs Mel Parnell | First | -- |
| Tuesday, May 6 |
| » Defeated White Sox (9-11), 11-2 | Fenway Park (11-4) | 13-5 | |
| » Starters: Joe Dobson vs Willard Nixon | First | -- |
| Wednesday, May 7 |
| » Defeated White Sox (9-12), 7-2 | Fenway Park (12-4) | 14-5 | Won 2 |
| » Starters: Ken Holcombe vs Bill Henry | First | -- |
| Thursday, May 8 |
| » Lost to White Sox (10-12), 4-2 | Fenway Park (12-5) | 14-6 | |
| » Starters: Saul Rogovin vs Ray Scarborough | First | -- |
| Friday, May 9 |
| » Lost to Yankees (9-11), 7-4 | Yankee Stadium (0-1) | 14-7 | Lost 2 |
| » Starters: Bill Wight vs Johnny Sain | Second | ½ out |
| Saturday, May 10 |
| » Lost to Yankees (10-11), 18-3 | Yankee Stadium (0-2) | 14-8 | Lost 3 |
| » Starters: Mickey McDermott vs Tom Morgan | Second | ½ out |
| Sunday, May 11 |
| » Lost to Yankees (11-11), 1-0 | Yankee Stadium (0-3) | 14-9 | Lost 4 |
| » Starters: Mel Parnell vs Allie Reynolds | Third | 2 out |
| Tuesday, May 13 |
| » Lost to White Sox (14-13), 5-0 | Comiskey Park I (0-1) | 14-10 | Lost 5 |
| » Starters: Willard Nixon vs Billy Pierce | Third | 3 out |
| Wednesday, May 14 |
| » Lost to White Sox (15-13), 6-3 | Comiskey Park I (0-2) | 14-11 | Lost 6 |
| » Starters: Bill Henry vs Saul Rogovin | Third | 3 out |
| Thursday, May 15 |
| » Defeated White Sox (15-14), 1-0 | Comiskey Park I (1-2) | 15-11 | |
| » Starters: Ray Scarborough vs Ken Holcombe | Third | 2½ out |
| Friday, May 16 |
| » Lost to Browns (14-16), 2-1 | Sportsman's Park III (0-1) | 15-12 | |
| » Starters: Mickey McDermott vs Earl Harrist | Third | 2½ out |
| Saturday, May 17 |
| » Lost to Browns (15-16), 2-1 | Sportsman's Park III (0-2) | 15-13 | Lost 2 |
| » Starters: Mel Parnell vs Ned Garver | Third | 3½ out |
| Sunday, May 18 |
| » Defeated Tigers (7-20), 7-4 | Tiger Stadium (1-0) | 16-13 | |
| » Starters: Bill Wight vs Marlin Stuart | Third | 3 out |
| Monday, May 19 |
| » Defeated Tigers (7-21), 3-2 | Tiger Stadium (2-0) | 17-13 | Won 2 |
| » Starters: Bill Henry vs Art Houtteman | Third | 2½ out |
| Wednesday, May 21 |
| » Lost to Indians (21-11), 5-1 | Cleveland Stadium (0-1) | 17-14 | |
| » Starters: Ray Scarborough vs Early Wynn | Fourth | 3½ out |
| Thursday, May 22 |
| » Defeated Indians (21-12), 3-2 | Cleveland Stadium (1-1) | 18-14 | |
| » Starters: Mickey McDermott vs Bob Lemon | Third | 2½ out |
| Saturday, May 24 |
| » Defeated Yankees (16-14), 5-2 | Fenway Park (13-5) | 19-14 | Won 2 |
| » Starters: Vic Raschi vs Ellis Kinder | Third | 3 out |
| Monday, May 26 |
| » Defeated Yankees (16-15), 6-3 | Fenway Park (14-5) | 20-14 | Won 3 |
| » Starters: Johnny Sain vs Mel Parnell | Second | 2½ out |
| Tuesday, May 27 |
| » Lost to Athletics (13-18), 7-3 | Fenway Park (14-6) | 20-15 | |
| » Starters: Harry Byrd vs Ray Scarborough | Second | 2½ out |
| Thursday, May 29 |
| » Defeated Senators (20-16), 1-0 | Fenway Park (15-6) | 21-15 | |
| » Starters: Bob Porterfield vs Mickey McDermott | Second | 2 out |
| Friday, May 30 |
| » Lost to Senators (21-16), 5-2 | Fenway Park (15-7) | 21-16 | |
| » Starters: Spec Shea vs Ellis Kinder | Second | 2 out |
| » Defeated Senators (21-17), 5-3 | Fenway Park (16-7) | 22-16 | |
| » Starters: Julio Moreno vs Mel Parnell | Second | 2 out |
| Saturday, May 31 |
| » Lost to White Sox (23-19), 7-3 | Fenway Park (16-8) | 22-17 | |
| » Starters: Marv Grissom vs Ray Scarborough | Second | 1½ out |
| Sunday, June 1 |
| » Defeated White Sox (23-20), 3-2 | Fenway Park (17-8) | 23-17 | |
| » Starters: Saul Rogovin vs Bill Henry | Second | 1 out |
| Monday, June 2 |
| » Defeated White Sox (23-21), 6-2 | Fenway Park (18-8) | 24-17 | Won 2 |
| » Starters: Ken Holcombe vs Willard Nixon | First | -- |
| Tuesday, June 3 |
| » Lost to Indians (26-18), 6-0 | Fenway Park (18-9) | 24-18 | |
| » Starters: Mike Garcia vs Mickey McDermott | Second | 1 out |
| Wednesday, June 4 |
| » Defeated Indians (26-19), 13-11 | Fenway Park (19-9) | 25-18 | |
| » Starters: Bob Feller vs Mel Parnell | First | -- |
| Thursday, June 5 |
| » Lost to Indians (27-19), 5-0 | Fenway Park (19-10) | 25-19 | |
| » Starters: Early Wynn vs Ellis Kinder | Second | 1 out |
| Friday, June 6 |
| » Lost to Tigers (15-29), 4-2 | Fenway Park (19-11) | 25-20 | Lost 2 |
| » Starters: Ted Gray vs Bill Henry | Second | 2 out |
| Saturday, June 7 |
| » Defeated Tigers (15-30), 11-9 | Fenway Park (20-11) | 26-20 | |
| » Starters: Art Houtteman vs Willard Nixon | Second | 2 out |
| Sunday, June 8 |
| » Defeated Tigers (15-31), 5-2 | Fenway Park (21-11) | 27-20 | Won 2 |
| » Starters: Bill Wight vs Mickey McDermott | First | -- |
| » Defeated Tigers (15-32), 5-2 | Fenway Park (22-11) | 28-20 | Won 3 |
| » Starters: Virgil Trucks vs Dizzy Trout | First | -- |
| Monday, June 9 |
| » Defeated Tigers (15-33), 9-8 | Fenway Park (23-11) | 29-20 | Won 4 |
| » Starters: Marlin Stuart vs Mel Parnell | First | -- |
| Tuesday, June 10 |
| » Lost to Browns (23-29), 7-4 | Fenway Park (23-12) | 29-21 | |
| » Starters: Ned Garver vs Ike Delock | Third | 3 out |
| Wednesday, June 11 |
| » Defeated Browns (23-30), 11-9 | Fenway Park (24-12) | 30-21 | |
| » Starters: Earl Harrist vs Willard Nixon | Second | 3 out |
| Thursday, June 12 |
| » Defeated Browns (23-31), 7-5 | Fenway Park (25-12) | 31-21 | Won 2 |
| » Starters: Duane Pillette vs Sid Hudson | Second | 3 out |
| Friday, June 13 |
| Future Red Sox Ernie Whitt is born in Detroit, MI. |
| Saturday, June 14 |
| » Lost to White Sox (29-25), 4-2 | Comiskey Park I (1-3) | 31-22 | |
| » Starters: Mel Parnell vs Hal Brown | Second | 2½ out |
| Sunday, June 15 |
| » Lost to White Sox (30-25), 7-2 | Comiskey Park I (1-4) | 31-23 | Lost 2 |
| » Starters: Willard Nixon vs Saul Rogovin | Second | 2½ out |
| » Defeated White Sox (30-26), 3-2 | Comiskey Park I (2-4) | 32-23 | |
| » Starters: Dizzy Trout vs Chuck Stobbs | Second | 2½ out |
| » Major-league debuts: Dick Brodowski (Red Sox) |
| Tuesday, June 17 |
| » Lost to Browns (26-32), 3-1 | Sportsman's Park III (0-3) | 32-24 | |
| » Starters: Mickey McDermott vs Bob Cain | Second | 2½ out |
| Wednesday, June 18 |
| » Lost to Browns (27-32), 4-3 | Sportsman's Park III (0-4) | 32-25 | Lost 2 |
| » Starters: Bill Henry vs Duane Pillette | Second | 2½ out |
| Thursday, June 19 |
| » Defeated Browns (27-33), 2-0 | Sportsman's Park III (1-4) | 33-25 | |
| » Starters: Ike Delock vs Ken Holcombe | Second | 2½ out |
| Friday, June 20 |
| » Lost to Indians (33-28), 9-2 | Cleveland Stadium (1-2) | 33-26 | |
| » Starters: Mel Parnell vs Bob Lemon | Second | 2½ out |
| Saturday, June 21 |
| » Defeated Indians (33-29), 3-1 | Cleveland Stadium (2-2) | 34-26 | |
| » Starters: Sid Hudson vs Bob Feller | Second | 2½ out |
| Sunday, June 22 |
| » Lost to Indians (34-29), 7-0 | Cleveland Stadium (2-3) | 34-27 | |
| » Starters: Willard Nixon vs Steve Gromek | Third | 2½ out |
| » Lost to Indians (35-29), 5-4 | Cleveland Stadium (2-4) | 34-28 | Lost 2 |
| » Starters: Dizzy Trout vs Mike Garcia | Third | 2½ out |
| Monday, June 23 |
| » Defeated Tigers (19-42), 12-6 | Tiger Stadium (3-0) | 35-28 | |
| » Starters: Ike Delock vs Ted Gray | Second | 2½ out |
| Tuesday, June 24 |
| » Lost to Tigers (20-42), 7-1 | Tiger Stadium (3-1) | 35-29 | |
| » Starters: Bill Henry vs Virgil Trucks | Third | 3½ out |
| Wednesday, June 25 |
| » Defeated Tigers (20-43), 10-3 | Tiger Stadium (4-1) | 36-29 | |
| » Starters: Dick Brodowski vs Fred Hutchinson | Second | 2½ out |
| Friday, June 27 |
| » Lost to Senators (33-28), 5-3 | Fenway Park (25-13) | 36-30 | |
| » Starters: Connie Marrero vs Sid Hudson | Second | 3½ out |
| Saturday, June 28 |
| » Lost to Senators (34-28), 5-1 | Fenway Park (25-14) | 36-31 | Lost 2 |
| » Starters: Walt Masterson vs Ike Delock | Fourth | 3½ out |
| Future Red Sox Joe Sambito is born in Brooklyn, NY. |
| Monday, June 30 |
| » Defeated Yankees (39-26), 4-3 | Yankee Stadium (1-3) | 37-31 | |
| » Starters: Dick Brodowski vs Bob Kuzava | Third | 3½ out |
| Tuesday, July 1 |
| » Lost to Yankees (40-26), 3-2 | Yankee Stadium (1-4) | 37-32 | |
| » Starters: Dizzy Trout vs Vic Raschi | Fifth | 4½ out |
| Wednesday, July 2 |
| » Defeated Yankees (40-27), 5-4 | Yankee Stadium (2-4) | 38-32 | |
| » Starters: Sid Hudson vs Ed Lopat | Fourth | 3½ out |
| Thursday, July 3 |
| » Lost to Athletics (29-34), 4-3 | Shibe Park (0-1) | 38-33 | |
| » Starters: Ike Delock vs Carl Scheib | Fifth | 4 out |
| Friday, July 4 |
| » Defeated Athletics (29-35), 10-5 | Shibe Park (1-1) | 39-33 | |
| » Starters: Mel Parnell vs Bob Hooper | Fourth | 5 out |
| » Lost to Athletics (30-35), 4-3 | Shibe Park (1-2) | 39-34 | |
| » Starters: Willard Nixon vs Harry Byrd | Fourth | 5 out |
| Saturday, July 5 |
| » Lost to Senators (38-34), 4-3 | Griffith Stadium (2-2) | 39-35 | Lost 2 |
| » Starters: Dick Brodowski vs Spec Shea | Fifth | 6 out |
| Sunday, July 6 |
| » Lost to Senators (39-34), 5-2 | Griffith Stadium (2-3) | 39-36 | Lost 3 |
| » Starters: Mickey McDermott vs Julio Moreno | Fifth | 6½ out |
| Friday, July 11 |
| » Defeated Tigers (25-50), 16-6 | Fenway Park (26-14) | 40-36 | |
| » Starters: Ted Gray vs Dick Brodowski | Fourth | 5½ out |
| » Defeated Tigers (25-51), 5-3 | Fenway Park (27-14) | 41-36 | Won 2 |
| » Starters: Virgil Trucks vs Mel Parnell | Fourth | 5½ out |
| Former Red Sox Hub Leonard dies in Fresno, CA at the age of 61. |
| Saturday, July 12 |
| » Defeated Tigers (25-52), 5-4 | Fenway Park (28-14) | 42-36 | Won 3 |
| » Starters: Bill Wight vs Sid Hudson | Fourth | 5½ out |
| Sunday, July 13 |
| » Defeated Browns (33-48), 8-5 | Fenway Park (29-14) | 43-36 | Won 4 |
| » Starters: Gene Bearden vs Dizzy Trout | Fourth | 5½ out |
| » Defeated Browns (33-49), 4-0 | Fenway Park (30-14) | 44-36 | Won 5 |
| » Starters: Ned Garver vs Mickey McDermott | Fourth | 5½ out |
| Monday, July 14 |
| » Lost to Browns (34-49), 7-5 | Fenway Park (30-15) | 44-37 | |
| » Starters: Dave Madison vs Ray Scarborough | Fourth | 5½ out |
| Tuesday, July 15 |
| » Defeated White Sox (47-39), 7-5 | Fenway Park (31-15) | 45-37 | |
| » Starters: Saul Rogovin vs Dick Brodowski | Third | 4½ out |
| Wednesday, July 16 |
| » Defeated White Sox (47-40), 7-3 | Fenway Park (32-15) | 46-37 | Won 2 |
| » Starters: Joe Dobson vs Mel Parnell | Third | 5 out |
| Thursday, July 17 |
| » Defeated White Sox (47-41), 2-1 | Fenway Park (33-15) | 47-37 | Won 3 |
| » Starters: Marv Grissom vs Dizzy Trout | Second | 4½ out |
| Friday, July 18 |
| » Defeated Indians (48-39), 9-2 | Fenway Park (34-15) | 48-37 | Won 4 |
| » Starters: Lou Brissie vs Mickey McDermott | Second | 4½ out |
| Saturday, July 19 |
| » Lost to Indians (49-39), 4-0 | Fenway Park (34-16) | 48-38 | |
| » Starters: Bob Lemon vs Sid Hudson | Second | 5½ out |
| Sunday, July 20 |
| » Defeated Indians (49-40), 8-7 | Fenway Park (35-16) | 49-38 | |
| » Starters: Early Wynn vs Dick Brodowski | Second | 4½ out |
| Tuesday, July 22 |
| » Defeated White Sox (48-44), 4-2 | Comiskey Park I (3-4) | 50-38 | Won 2 |
| » Starters: Mel Parnell vs Marv Grissom | Second | 5 out |
| Wednesday, July 23 |
| » Defeated White Sox (48-45), 10-4 | Comiskey Park I (4-4) | 51-38 | Won 3 |
| » Starters: Sid Hudson vs Hal Brown | Second | 4 out |
| Thursday, July 24 |
| » Lost to White Sox (49-45), 3-0 | Comiskey Park I (4-5) | 51-39 | |
| » Starters: Dizzy Trout vs Lou Kretlow | Second | 4 out |
| Friday, July 25 |
| » Lost to Browns (37-58), 3-2 | Sportsman's Park III (1-5) | 51-40 | Lost 2 |
| » Starters: Dick Brodowski vs Tommy Byrne | Second | 4 out |
| Saturday, July 26 |
| » Lost to Browns (38-58), 7-2 | Sportsman's Park III (1-6) | 51-41 | Lost 3 |
| » Starters: Mickey McDermott vs Dave Madison | Second | 4 out |
| Sunday, July 27 |
| » Lost to Browns (39-58), 8-1 | Sportsman's Park III (1-7) | 51-42 | Lost 4 |
| » Starters: Mel Parnell vs Gene Bearden | Third | 4 out |
| » Defeated Browns (39-59), 9-3 | Sportsman's Park III (2-7) | 52-42 | |
| » Starters: Willard Nixon vs Duane Pillette | Third | 4 out |
| Tuesday, July 29 |
| » Lost to Indians (55-43), 4-1 | Cleveland Stadium (2-5) | 52-43 | |
| » Starters: Sid Hudson vs Early Wynn | Third | 4½ out |
| Wednesday, July 30 |
| » Defeated Indians (55-44), 5-4 | Cleveland Stadium (3-5) | 53-43 | |
| » Starters: Dick Brodowski vs Bob Feller | Third | 3½ out |
| Thursday, July 31 |
| » Lost to Indians (56-44), 8-2 | Cleveland Stadium (3-6) | 53-44 | |
| » Starters: Ralph Brickner vs Bob Lemon | Third | 4½ out |
| Friday, August 1 |
| » Defeated Tigers (35-66), 3-1 | Tiger Stadium (5-1) | 54-44 | |
| » Starters: Mel Parnell vs Bill Wight | Third | 3½ out |
| Saturday, August 2 |
| » Defeated Tigers (35-67), 10-5 | Tiger Stadium (6-1) | 55-44 | Won 2 |
| » Starters: Dizzy Trout vs Hal Newhouser | Third | 2½ out |
| Sunday, August 3 |
| » Lost to Tigers (36-67), 6-0 | Tiger Stadium (6-2) | 55-45 | |
| » Starters: Dick Brodowski vs Art Houtteman | Third | 4 out |
| Tuesday, August 5 |
| » Lost to Athletics (51-48), 5-3 | Shibe Park (1-3) | 55-46 | Lost 2 |
| » Starters: Sid Hudson vs Bobby Shantz | Third | 5½ out |
| Thursday, August 7 |
| » Lost to Athletics (52-48), 7-5 | Shibe Park (1-4) | 55-47 | Lost 3 |
| » Starters: Dizzy Trout vs Harry Byrd | Third | 5 out |
| » Defeated Athletics (52-49), 8-4 | Shibe Park (2-4) | 56-47 | |
| » Starters: Willard Nixon vs Carl Scheib | Third | 5 out |
| Saturday, August 9 |
| » Defeated Yankees (64-46), 3-1 | Yankee Stadium (3-4) | 57-47 | Won 2 |
| » Starters: Mel Parnell vs Vic Raschi | Third | 4 out |
| Monday, August 11 |
| » Lost to Yankees (65-46), 7-0 | Yankee Stadium (3-5) | 57-48 | |
| » Starters: Sid Hudson vs Allie Reynolds | Third | 5 out |
| Tuesday, August 12 |
| » Lost to Athletics (55-51), 4-3 | Fenway Park (35-17) | 57-49 | Lost 2 |
| » Starters: Carl Scheib vs Dizzy Trout | Third | 5½ out |
| Wednesday, August 13 |
| » Defeated Athletics (55-52), 4-0 | Fenway Park (36-17) | 58-49 | |
| » Starters: Dick Fowler vs Mel Parnell | Third | 5 out |
| Thursday, August 14 |
| » Defeated Athletics (55-53), 5-4 | Fenway Park (37-17) | 59-49 | Won 2 |
| » Starters: Harry Byrd vs Dick Brodowski | Third | 4½ out |
| » Defeated Athletics (55-54), 4-2 | Fenway Park (38-17) | 60-49 | Won 3 |
| » Starters: Bobo Newsom vs Willard Nixon | Third | 4½ out |
| Friday, August 15 |
| » Defeated Yankees (67-48), 3-2 | Fenway Park (39-17) | 61-49 | Won 4 |
| » Starters: Johnny Sain vs Sid Hudson | Third | 3½ out |
| Saturday, August 16 |
| » Lost to Yankees (68-48), 5-4 | Fenway Park (39-18) | 61-50 | |
| » Starters: Allie Reynolds vs Ray Scarborough | Third | 4½ out |
| Sunday, August 17 |
| » Lost to Yankees (69-48), 3-2 | Fenway Park (39-19) | 61-51 | Lost 2 |
| » Starters: Ed Lopat vs Mel Parnell | Third | 5½ out |
| Monday, August 18 |
| » Lost to Yankees (70-48), 4-2 | Fenway Park (39-20) | 61-52 | Lost 3 |
| » Starters: Vic Raschi vs Dizzy Trout | Third | 6½ out |
| Tuesday, August 19 |
| » Defeated Indians (67-50), 6-5 | Fenway Park (40-20) | 62-52 | |
| » Starters: Early Wynn vs Dick Brodowski | Third | 5½ out |
| Future Red Sox Tim Blackwell is born in San Diego, CA. |
| Wednesday, August 20 |
| » Lost to Indians (68-50), 18-8 | Fenway Park (40-21) | 62-53 | |
| » Starters: Bob Lemon vs Mickey McDermott | Third | 5½ out |
| Thursday, August 21 |
| » Defeated Indians (68-51), 4-1 | Fenway Park (41-21) | 63-53 | |
| » Starters: Steve Gromek vs Sid Hudson | Third | 4½ out |
| Friday, August 22 |
| » Lost to White Sox (64-58), 4-1 | Fenway Park (41-22) | 63-54 | |
| » Starters: Joe Dobson vs Ike Delock | Third | 4½ out |
| Saturday, August 23 |
| » Defeated White Sox (64-59), 4-3 | Fenway Park (42-22) | 64-54 | |
| » Starters: Hal Brown vs Mel Parnell | Third | 4½ out |
| Sunday, August 24 |
| » Defeated Browns (52-74), 2-1 | Fenway Park (43-22) | 65-54 | Won 2 |
| » Starters: Duane Pillette vs Ellis Kinder | Third | 4 out |
| » Defeated Browns (52-75), 12-1 | Fenway Park (44-22) | 66-54 | Won 3 |
| » Starters: Bobby Hogue vs Dizzy Trout | Third | 4 out |
| Tuesday, August 26 |
| » Defeated Tigers (42-82), 11-3 | Fenway Park (45-22) | 67-54 | Won 4 |
| » Starters: Bill Wight vs Sid Hudson | Third | 3½ out |
| Wednesday, August 27 |
| » Defeated Tigers (42-83), 5-0 | Fenway Park (46-22) | 68-54 | Won 5 |
| » Starters: Dave Madison vs Mel Parnell | Third | 3½ out |
| Thursday, August 28 |
| » Lost to Athletics (65-59), 6-4 | Shibe Park (2-5) | 68-55 | |
| » Starters: Mickey McDermott vs Harry Byrd | Third | 4 out |
| Friday, August 29 |
| » Lost to Athletics (66-59), 6-1 | Shibe Park (2-6) | 68-56 | Lost 2 |
| » Starters: Dick Brodowski vs Carl Scheib | Third | 4½ out |
| » Lost to Athletics (67-59), 7-5 | Shibe Park (2-7) | 68-57 | Lost 3 |
| » Starters: Ike Delock vs Charlie Bishop | Third | 4½ out |
| Sunday, August 31 |
| » Defeated Athletics (67-60), 11-1 | Shibe Park (3-7) | 69-57 | |
| » Starters: Mickey McDermott vs Bobby Shantz | Third | 5½ out |
| » Lost to Athletics (68-60), 2-0 | Shibe Park (3-8) | 69-58 | |
| » Starters: Willard Nixon vs Harry Byrd | Third | 5½ out |
| Monday, September 1 |
| » Lost to Yankees (77-54), 5-1 | Yankee Stadium (3-6) | 69-59 | Lost 2 |
| » Starters: Ellis Kinder vs Ray Scarborough | Third | 6½ out |
| Tuesday, September 2 |
| » Lost to Yankees (78-54), 5-0 | Yankee Stadium (3-7) | 69-60 | Lost 3 |
| » Starters: Mel Parnell vs Tom Gorman | Third | 8½ out |
| » Lost to Yankees (79-54), 4-0 | Yankee Stadium (3-8) | 69-61 | Lost 4 |
| » Starters: Sid Hudson vs Ewell Blackwell | Third | 8½ out |
| Wednesday, September 3 |
| » Lost to Senators (70-64), 9-2 | Griffith Stadium (2-4) | 69-62 | Lost 5 |
| » Starters: Dizzy Trout vs Randy Gumpert | Fourth | 8½ out |
| Thursday, September 4 |
| » Lost to Senators (71-64), 4-2 | Griffith Stadium (2-5) | 69-63 | Lost 6 |
| » Starters: Mickey McDermott vs Bob Porterfield | Fifth | 9½ out |
| Friday, September 5 |
| » Lost to Senators (72-64), 2-0 | Griffith Stadium (2-6) | 69-64 | Lost 7 |
| » Starters: Ellis Kinder vs Raul Sanchez | Sixth | 9½ out |
| Saturday, September 6 |
| » Defeated Athletics (71-65), 6-4 | Fenway Park (47-22) | 70-64 | |
| » Starters: Carl Scheib vs Mel Parnell | Fourth | 9 out |
| » Defeated Athletics (71-66), 10-2 | Fenway Park (48-22) | 71-64 | Won 2 |
| » Starters: Charlie Bishop vs Willard Nixon | Fourth | 9 out |
| » Major-league debuts: Walt Kellner (Athletics) |
| Sunday, September 7 |
| » Defeated Athletics (71-67), 12-5 | Fenway Park (49-22) | 72-64 | Won 3 |
| » Starters: Harry Byrd vs Sid Hudson | Third | 9 out |
| Tuesday, September 9 |
| » Lost to Tigers (46-91), 4-3 | Tiger Stadium (6-3) | 72-65 | |
| » Starters: Dizzy Trout vs Art Houtteman | Fourth | 9 out |
| Wednesday, September 10 |
| » Lost to Tigers (47-91), 6-2 | Tiger Stadium (6-4) | 72-66 | Lost 2 |
| » Starters: Mel Parnell vs Bill Wight | Fourth | 10 out |
| » Major-league debuts: Bill Tuttle (Tigers) Milt Bolling and Hersh Freeman (Red Sox) |
| Thursday, September 11 |
| » Lost to Tigers (48-91), 5-4 | Tiger Stadium (6-5) | 72-67 | Lost 3 |
| » Starters: Mickey McDermott vs Virgil Trucks | Fourth | 10½ out |
| Friday, September 12 |
| » Lost to Indians (84-58), 5-0 | Cleveland Stadium (3-7) | 72-68 | Lost 4 |
| » Starters: Sid Hudson vs Early Wynn | Fourth | 11½ out |
| Saturday, September 13 |
| » Defeated Indians (84-59), 4-3 | Cleveland Stadium (4-7) | 73-68 | |
| » Starters: Ellis Kinder vs Bob Lemon | Fourth | 11½ out |
| Sunday, September 14 |
| » Lost to White Sox (75-68), 4-3 | Comiskey Park I (4-6) | 73-69 | |
| » Starters: Dizzy Trout vs Saul Rogovin | Sixth | 12½ out |
| Monday, September 15 |
| » Lost to White Sox (76-68), 4-2 | Comiskey Park I (4-7) | 73-70 | Lost 2 |
| » Starters: Mel Parnell vs Lou Kretlow | Sixth | 13 out |
| Tuesday, September 16 |
| » Defeated Browns (58-86), 11-7 | Sportsman's Park III (3-7) | 74-70 | |
| » Starters: Mickey McDermott vs Duane Pillette | Fifth | 13 out |
| Wednesday, September 17 |
| » Lost to Browns (59-86), 10-4 | Sportsman's Park III (3-8) | 74-71 | |
| » Starters: George Schmees vs Bob Cain | Fifth | 14 out |
| Thursday, September 18 |
| Future Red Sox Sam Bowen is born in Brunswick, GA. |
| Friday, September 19 |
| » Lost to Senators (75-73), 5-3 | Griffith Stadium (2-7) | 74-72 | Lost 2 |
| » Starters: Sid Hudson vs Julio Moreno | Sixth | 14 out |
| Saturday, September 20 |
| » Lost to Senators (76-73), 10-6 | Griffith Stadium (2-8) | 74-73 | Lost 3 |
| » Starters: Mel Parnell vs Spec Shea | Sixth | 15 out |
| Sunday, September 21 |
| » Defeated Senators (76-74), 7-3 | Griffith Stadium (3-8) | 75-73 | |
| » Starters: Dizzy Trout vs Connie Marrero | Sixth | 15 out |
| Wednesday, September 24 |
| » Lost to Yankees (91-58), 3-2 | Fenway Park (49-23) | 75-74 | |
| » Starters: Vic Raschi vs Ellis Kinder | Sixth | 17 out |
| » Lost to Yankees (92-58), 8-6 | Fenway Park (49-24) | 75-75 | Lost 2 |
| » Starters: Tom Gorman vs Mel Parnell | Sixth | 17 out |
| Thursday, September 25 |
| » Lost to Yankees (93-58), 3-2 | Fenway Park (49-25) | 75-76 | Lost 3 |
| » Starters: Allie Reynolds vs Sid Hudson | Sixth | 18 out |
| Friday, September 26 |
| » Defeated Senators (76-76), 3-1 | Fenway Park (50-25) | 76-76 | |
| » Starters: Spec Shea vs Hersh Freeman | Fifth | 18 out |
| Saturday, September 27 |
| » Lost to Senators (77-76), 3-2 | Fenway Park (50-26) | 76-77 | |
| » Starters: Bob Porterfield vs Dizzy Trout | Sixth | 19 out |
| Sunday, September 28 |
| » Lost to Senators (78-76), 5-4 | Fenway Park (50-27) | 76-78 | Lost 2 |
| » Starters: Walt Masterson vs Mickey McDermott | Sixth | 19 out |
| Saturday, October 18 |
| Future Red Sox Allen Ripley is born in Norwood, MA. |
| Monday, November 3 |
| Former Red Sox Frank Smith dies in Pittsburgh, PA at the age of 74. |
| Saturday, November 8 |
| Future Red Sox Jerry Remy is |
