| Tuesday, January 2 |
| Future White Sox Jim Essian is born in Detroit, MI. Future White Sox Royle Stillman is born in Santa Monica, CA. |
| Tuesday, January 16 |
| Former White Sox Pid Purdy dies in Beatrice, NE at the age of 47. |
| Friday, January 26 |
| Former White Sox Bill Barrett dies in Cambridge, MA at the age of 51. |
| Thursday, February 8 |
| Future White Sox Steve Dillard is born in Memphis, TN. |
| Friday, February 9 |
| Future White Sox Eddie Solomon is born in Perry, GA. |
| Thursday, February 15 |
| Future White Sox Tommy Cruz is born in Arroyo, P.R. |
| Sunday, March 25 |
| Former White Sox Eddie Collins dies in Boston, MA at the age of 64. |
| Tuesday, April 17 |
| » Defeated Browns (0-1), 17-3 | Sportsman's Park III (1-0) | 1-0 | |
| » Starters: Billy Pierce vs Ned Garver | First | -- |
| Thursday, April 19 |
| » Defeated Browns (0-2), 13-5 | Sportsman's Park III (2-0) | 2-0 | Won 2 |
| » Starters: Marv Rotblatt vs Al Widmar | First | -- |
| » Major-league debuts: Hal Brown and Joe DeMaestri (White Sox) |
| Friday, April 20 |
| » Defeated Tigers (0-3), 5-0 | Comiskey Park I (1-0) | 3-0 | Won 3 |
| » Starters: Ted Gray vs Randy Gumpert | Second | ½ out |
| Saturday, April 21 |
| » Lost to Tigers (1-3), 7-6 | Comiskey Park I (1-1) | 3-1 | |
| » Starters: Hal Newhouser vs Lou Kretlow | Second | ½ out |
| Sunday, April 22 |
| » Defeated Tigers (1-4), 3-2 | Comiskey Park I (2-1) | 4-1 | |
| » Starters: Saul Rogovin vs Billy Pierce | Second | ½ out |
| Tuesday, April 24 |
| » Lost to Indians (6-1), 5-2 | Cleveland Stadium (0-1) | 4-2 | |
| » Starters: Bob Cain vs Bob Feller | Fourth | 1½ out |
| Wednesday, April 25 |
| » Defeated Browns (1-7), 8-6 | Comiskey Park I (3-1) | 5-2 | |
| » Starters: Al Widmar vs Randy Gumpert | Fourth | 1½ out |
| » Lost to Browns (2-7), 7-4 | Comiskey Park I (3-2) | 5-3 | |
| » Starters: Dick Starr vs Joe Dobson | Fourth | 1½ out |
| Saturday, April 28 |
| » Lost to Tigers (3-4), 7-4 | Tiger Stadium (0-1) | 5-4 | Lost 2 |
| » Starters: Billy Pierce vs Ted Gray | Fifth | 2½ out |
| Sunday, April 29 |
| » Defeated Tigers (3-5), 4-0 | Tiger Stadium (1-1) | 6-4 | |
| » Starters: Ken Holcombe vs Hal Newhouser | Fourth | 1 out |
| Monday, April 30 |
| » Major-league debuts: Earl Mossor (Dodgers) |
| Tuesday, May 1 |
| » Lost to Yankees (9-4), 8-3 | Comiskey Park I (3-3) | 6-5 | |
| » Starters: Vic Raschi vs Bob Cain | Fourth | 2 out |
| Wednesday, May 2 |
| » Lost to Yankees (10-4), 6-4 | Comiskey Park I (3-4) | 6-6 | Lost 2 |
| » Starters: Spec Shea vs Dick Littlefield | Fourth | 3 out |
| Thursday, May 3 |
| » Lost to Senators (10-3), 7-1 | Comiskey Park I (3-5) | 6-7 | Lost 3 |
| » Starters: Connie Marrero vs Billy Pierce | Fifth | 4 out |
| Friday, May 4 |
| » Defeated Senators (10-4), 6-5 | Comiskey Park I (4-5) | 7-7 | |
| » Starters: Al Sima vs Joe Dobson | Fifth | 4 out |
| Saturday, May 5 |
| » Defeated Senators (10-5), 7-0 | Comiskey Park I (5-5) | 8-7 | Won 2 |
| » Starters: Bob Kuzava vs Bob Cain | Fourth | 4 out |
| Sunday, May 6 |
| » Defeated Athletics (3-15), 4-1 | Comiskey Park I (6-5) | 9-7 | Won 3 |
| » Starters: Carl Scheib vs Ken Holcombe | Fourth | 3½ out |
| » Defeated Athletics (3-16), 8-3 | Comiskey Park I (7-5) | 10-7 | Won 4 |
| » Starters: Joe Coleman vs Lou Kretlow | Fourth | 3½ out |
| Tuesday, May 8 |
| » Lost to Athletics (4-16), 9-4 | Comiskey Park I (7-6) | 10-8 | |
| » Starters: Bobby Shantz vs Dick Littlefield | Fourth | 3 out |
| Friday, May 11 |
| » Defeated Indians (11-8), 12-1 | Comiskey Park I (8-6) | 11-8 | |
| » Starters: Early Wynn vs Joe Dobson | Third | 3 out |
| Saturday, May 12 |
| » Defeated Indians (11-9), 3-2 | Comiskey Park I (9-6) | 12-8 | Won 2 |
| » Starters: Mike Garcia vs Billy Pierce | Third | 3 out |
| Sunday, May 13 |
| » Lost to Indians (12-9), 11-2 | Comiskey Park I (9-7) | 12-9 | |
| » Starters: Bob Feller vs Ken Holcombe | Third | 2½ out |
| » Tied Indians, 4-4 | Comiskey Park I (9-7) | 12-9 | |
| » Starters: Bob Chakales vs Bob Cain | Third | 2½ out |
| Tuesday, May 15 |
| » Defeated Red Sox (12-11), 9-7 | Fenway Park (1-0) | 13-9 | |
| » Starters: Howie Judson vs Willard Nixon | Second | 2½ out |
| Wednesday, May 16 |
| » Defeated Red Sox (12-12), 9-5 | Fenway Park (2-0) | 14-9 | Won 2 |
| » Starters: Joe Dobson vs Chuck Stobbs | Second | 2½ out |
| Friday, May 18 |
| » Defeated Yankees (19-9), 7-4 | Yankee Stadium (1-0) | 15-9 | Won 3 |
| » Starters: Billy Pierce vs Spec Shea | Second | 2 out |
| Sunday, May 20 |
| » Defeated Senators (15-12), 5-4 | Griffith Stadium (1-0) | 16-9 | Won 4 |
| » Starters: Ken Holcombe vs Sandy Consuegra | Second | 2 out |
| Monday, May 21 |
| » Defeated Senators (15-13), 5-3 | Griffith Stadium (2-0) | 17-9 | Won 5 |
| » Starters: Joe Dobson vs Julio Moreno | Second | 2 out |
| Tuesday, May 22 |
| » Defeated Senators (15-14), 9-8 | Griffith Stadium (3-0) | 18-9 | Won 6 |
| » Starters: Saul Rogovin vs Bob Kuzava | Second | 2 out |
| Thursday, May 24 |
| » Defeated Athletics (9-23), 5-2 | Shibe Park (1-0) | 19-9 | Won 7 |
| » Starters: Randy Gumpert vs Joe Coleman | Second | 2 out |
| Friday, May 25 |
| » Defeated Indians (15-16), 6-4 | Cleveland Stadium (1-1) | 20-9 | Won 8 |
| » Starters: Billy Pierce vs Bob Lemon | Second | 2 out |
| Saturday, May 26 |
| » Defeated Indians (15-17), 6-0 | Cleveland Stadium (2-1) | 21-9 | Won 9 |
| » Starters: Ken Holcombe vs Mike Garcia | Second | 2 out |
| Sunday, May 27 |
| » Defeated Indians (15-18), 5-2 | Cleveland Stadium (3-1) | 22-9 | Won 10 |
| » Starters: Joe Dobson vs Early Wynn | Second | 2 out |
| » Defeated Indians (15-19), 6-4 | Cleveland Stadium (4-1) | 23-9 | Won 11 |
| » Starters: Howie Judson vs Steve Gromek | Second | 2 out |
| Monday, May 28 |
| » Defeated Browns (11-27), 4-2 | Comiskey Park I (10-7) | 24-9 | Won 12 |
| » Starters: Duane Pillette vs Saul Rogovin | First | -- |
| Wednesday, May 30 |
| » Defeated Browns (11-28), 5-2 | Comiskey Park I (11-7) | 25-9 | Won 13 |
| » Starters: Jim Suchecki vs Billy Pierce | First | -- |
| » Defeated Browns (11-29), 8-1 | Comiskey Park I (12-7) | 26-9 | Won 14 |
| » Starters: Al Widmar vs Randy Gumpert | First | -- |
| Saturday, June 2 |
| » Lost to Athletics (12-27), 5-1 | Comiskey Park I (12-8) | 26-10 | |
| » Starters: Bob Hooper vs Joe Dobson | First | -- |
| Sunday, June 3 |
| » Lost to Red Sox (26-14), 7-5 | Comiskey Park I (12-9) | 26-11 | Lost 2 |
| » Starters: Mel Parnell vs Ken Holcombe | First | -- |
| » Defeated Red Sox (26-15), 11-2 | Comiskey Park I (13-9) | 27-11 | |
| » Starters: Chuck Stobbs vs Howie Judson | First | -- |
| Monday, June 4 |
| » Defeated Red Sox (26-16), 6-5 | Comiskey Park I (14-9) | 28-11 | Won 2 |
| » Starters: Ray Scarborough vs Billy Pierce | First | -- |
| » Defeated Red Sox (26-17), 2-0 | Comiskey Park I (15-9) | 29-11 | Won 3 |
| » Starters: Bill Wight vs Saul Rogovin | First | -- |
| Tuesday, June 5 |
| » Defeated Red Sox (26-18), 10-2 | Comiskey Park I (16-9) | 30-11 | Won 4 |
| » Starters: Willard Nixon vs Randy Gumpert | First | -- |
| Wednesday, June 6 |
| » Defeated Senators (17-26), 4-2 | Comiskey Park I (17-9) | 31-11 | Won 5 |
| » Starters: Connie Marrero vs Lou Kretlow | First | -- |
| Thursday, June 7 |
| » Defeated Senators (17-27), 5-0 | Comiskey Park I (18-9) | 32-11 | Won 6 |
| » Starters: Julio Moreno vs Harry Dorish | First | -- |
| Friday, June 8 |
| » Lost to Yankees (30-17), 4-2 | Comiskey Park I (18-10) | 32-12 | |
| » Starters: Vic Raschi vs Ken Holcombe | First | -- |
| Saturday, June 9 |
| » Lost to Yankees (31-17), 10-5 | Comiskey Park I (18-11) | 32-13 | Lost 2 |
| » Starters: Spec Shea vs Billy Pierce | First | -- |
| Sunday, June 10 |
| » Lost to Yankees (32-17), 2-1 | Comiskey Park I (18-12) | 32-14 | Lost 3 |
| » Starters: Ed Lopat vs Saul Rogovin | First | -- |
| » Defeated Yankees (32-18), 11-7 | Comiskey Park I (19-12) | 33-14 | |
| » Starters: Allie Reynolds vs Joe Dobson | First | -- |
| Tuesday, June 12 |
| » Defeated Senators (18-30), 3-0 | Griffith Stadium (4-0) | 34-14 | Won 2 |
| » Starters: Lou Kretlow vs Connie Marrero | First | -- |
| Thursday, June 14 |
| » Defeated Senators (18-31), 8-7 | Griffith Stadium (5-0) | 35-14 | Won 3 |
| » Starters: Billy Pierce vs Sid Hudson | First | -- |
| » Defeated Senators (18-32), 14-5 | Griffith Stadium (6-0) | 36-14 | Won 4 |
| » Starters: Joe Dobson vs Al Sima | First | -- |
| Friday, June 15 |
| » Lost to Athletics (16-35), 4-3 | Shibe Park (1-1) | 36-15 | |
| » Starters: Saul Rogovin vs Bob Hooper | First | -- |
| » Lost to Athletics (17-35), 12-5 | Shibe Park (1-2) | 36-16 | Lost 2 |
| » Starters: Ken Holcombe vs Bobby Shantz | First | -- |
| Saturday, June 16 |
| » Lost to Athletics (18-35), 6-5 | Shibe Park (1-3) | 36-17 | Lost 3 |
| » Starters: Howie Judson vs Dick Fowler | First | -- |
| Sunday, June 17 |
| » Defeated Athletics (18-36), 4-1 | Shibe Park (2-3) | 37-17 | |
| » Starters: Randy Gumpert vs Carl Scheib | First | -- |
| » Defeated Athletics (18-37), 9-0 | Shibe Park (3-3) | 38-17 | Won 2 |
| » Starters: Luis Aloma vs Alex Kellner | First | -- |
| Tuesday, June 19 |
| » Lost to Yankees (35-20), 11-9 | Yankee Stadium (1-1) | 38-18 | |
| » Starters: Marv Rotblatt vs Stubby Overmire | First | -- |
| » Defeated Yankees (35-21), 5-4 | Yankee Stadium (2-1) | 39-18 | |
| » Starters: Joe Dobson vs Vic Raschi | First | -- |
| Wednesday, June 20 |
| » Lost to Yankees (36-21), 2-1 | Yankee Stadium (2-2) | 39-19 | |
| » Starters: Billy Pierce vs Ed Lopat | First | -- |
| Thursday, June 21 |
| » Defeated Yankees (36-22), 5-2 | Yankee Stadium (3-2) | 40-19 | |
| » Starters: Saul Rogovin vs Spec Shea | First | -- |
| Friday, June 22 |
| » Lost to Red Sox (35-25), 6-5 | Fenway Park (2-1) | 40-20 | |
| » Starters: Randy Gumpert vs Mel Parnell | First | -- |
| Saturday, June 23 |
| » Lost to Red Sox (36-25), 8-7 | Fenway Park (2-2) | 40-21 | Lost 2 |
| » Starters: Howie Judson vs Ray Scarborough | First | -- |
| Sunday, June 24 |
| » Defeated Red Sox (36-26), 6-5 | Fenway Park (3-2) | 41-21 | |
| » Starters: Joe Dobson vs Chuck Stobbs | First | -- |
| » Lost to Red Sox (37-26), 8-6 | Fenway Park (3-3) | 41-22 | |
| » Starters: Harry Dorish vs Bill Wight | First | -- |
| Tuesday, June 26 |
| » Defeated Tigers (30-30), 11-3 | Comiskey Park I (20-12) | 42-22 | |
| » Starters: Bob Cain vs Randy Gumpert | First | -- |
| Wednesday, June 27 |
| » Lost to Tigers (31-30), 3-2 | Comiskey Park I (20-13) | 42-23 | |
| » Starters: Ted Gray vs Saul Rogovin | First | -- |
| Friday, June 29 |
| » Defeated Browns (19-46), 10-3 | Comiskey Park I (21-13) | 43-23 | |
| » Starters: Tommy Byrne vs Howie Judson | First | -- |
| Future White Sox Bruce Kimm is born in Cedar Rapids, IA. |
| Saturday, June 30 |
| » Lost to Browns (20-46), 4-3 | Comiskey Park I (21-14) | 43-24 | |
| » Starters: Dick Starr vs Joe Dobson | First | -- |
| Sunday, July 1 |
| » Defeated Browns (20-47), 2-1 | Comiskey Park I (22-14) | 44-24 | |
| » Starters: Duane Pillette vs Ken Holcombe | Second | 1 out |
| » Lost to Browns (21-47), 3-1 | Comiskey Park I (22-15) | 44-25 | |
| » Starters: Ned Garver vs Lou Kretlow | Second | 1 out |
| Future White Sox Jim Otten is born in Lewistown, MT. |
| Monday, July 2 |
| » Lost to Indians (39-30), 3-2 | Comiskey Park I (22-16) | 44-26 | Lost 2 |
| » Starters: Mike Garcia vs Saul Rogovin | Second | 1 out |
| Tuesday, July 3 |
| » Defeated Indians (39-31), 4-1 | Comiskey Park I (23-16) | 45-26 | |
| » Starters: Bob Lemon vs Billy Pierce | Second | 1½ out |
| Wednesday, July 4 |
| » Lost to Tigers (32-34), 6-3 | Tiger Stadium (1-2) | 45-27 | |
| » Starters: Randy Gumpert vs Hal Newhouser | First | -- |
| » Defeated Tigers (32-35), 5-1 | Tiger Stadium (2-2) | 46-27 | |
| » Starters: Joe Dobson vs Dizzy Trout | First | -- |
| Thursday, July 5 |
| » Lost to Tigers (33-35), 8-0 | Tiger Stadium (2-3) | 46-28 | |
| » Starters: Lou Kretlow vs Fred Hutchinson | Second | 1½ out |
| Future White Sox Goose Gossage is born in Colorado Springs, CO. |
| Friday, July 6 |
| » Defeated Browns (21-50), 4-3 | Sportsman's Park III (3-0) | 47-28 | |
| » Starters: Ken Holcombe vs Dick Starr | Second | 2 out |
| » Lost to Browns (22-50), 4-1 | Sportsman's Park III (3-1) | 47-29 | |
| » Starters: Howie Judson vs Ned Garver | Second | 2 out |
| Former White Sox Ted Easterly dies in Clearlake Highlands, CA at the age of 67. |
| Saturday, July 7 |
| » Defeated Browns (22-51), 5-3 | Sportsman's Park III (4-1) | 48-29 | |
| » Starters: Saul Rogovin vs Duane Pillette | First | -- |
| Sunday, July 8 |
| » Defeated Browns (22-52), 5-4 | Sportsman's Park III (5-1) | 49-29 | Won 2 |
| » Starters: Billy Pierce vs Tommy Byrne | First | -- |
| Tuesday, July 10 |
| Former White Sox Bobby Messenger dies in Bath, ME at the age of 68. |
| Thursday, July 12 |
| » Lost to Red Sox (48-29), 3-2 | Comiskey Park I (23-17) | 49-30 | |
| » Starters: Mel Parnell vs Joe Dobson | Third | 1 out |
| » Lost to Red Sox (49-29), 5-4 | Comiskey Park I (23-18) | 49-31 | Lost 2 |
| » Starters: Leo Kiely vs Saul Rogovin | Third | 1 out |
| Friday, July 13 |
| » Defeated Red Sox (49-30), 5-4 | Comiskey Park I (24-18) | 50-31 | |
| » Starters: Mickey McDermott vs Billy Pierce | Second | 1 out |
| Saturday, July 14 |
| » Lost to Red Sox (50-30), 3-2 | Comiskey Park I (24-19) | 50-32 | |
| » Starters: Chuck Stobbs vs Ken Holcombe | Second | 1 out |
| Sunday, July 15 |
| » Lost to Athletics (33-49), 3-1 | Comiskey Park I (24-20) | 50-33 | Lost 2 |
| » Starters: Bob Hooper vs Randy Gumpert | Second | 2 out |
| » Lost to Athletics (34-49), 5-0 | Comiskey Park I (24-21) | 50-34 | Lost 3 |
| » Starters: Sam Zoldak vs Howie Judson | Second | 2 out |
| Monday, July 16 |
| » Defeated Athletics (34-50), 9-5 | Comiskey Park I (25-21) | 51-34 | |
| » Starters: Bobby Shantz vs Joe Dobson | Second | 1 out |
| Tuesday, July 17 |
| » Defeated Yankees (48-33), 4-3 | Comiskey Park I (26-21) | 52-34 | Won 2 |
| » Starters: Allie Reynolds vs Saul Rogovin | Second | 1 out |
| Wednesday, July 18 |
| » Lost to Yankees (49-33), 5-1 | Comiskey Park I (26-22) | 52-35 | |
| » Starters: Vic Raschi vs Billy Pierce | Second | 1 out |
| Thursday, July 19 |
| » Defeated Yankees (49-34), 2-1 | Comiskey Park I (27-22) | 53-35 | |
| » Starters: Ed Lopat vs Howie Judson | Second | 1 out |
| Friday, July 20 |
| » Lost to Senators (37-49), 2-1 | Comiskey Park I (27-23) | 53-36 | |
| » Starters: Sid Hudson vs Lou Kretlow | Second | 1 out |
| Saturday, July 21 |
| » Lost to Senators (38-49), 10-5 | Comiskey Park I (27-24) | 53-37 | Lost 2 |
| » Starters: Julio Moreno vs Randy Gumpert | Fourth | 1 out |
| Sunday, July 22 |
| » Lost to Senators (39-49), 7-6 | Comiskey Park I (27-25) | 53-38 | Lost 3 |
| » Starters: Connie Marrero vs Saul Rogovin | Third | 2½ out |
| » Lost to Senators (40-49), 11-5 | Comiskey Park I (27-26) | 53-39 | Lost 4 |
| » Starters: Fred Sanford vs Ken Holcombe | Third | 2½ out |
| Tuesday, July 24 |
| » Lost to Red Sox (55-35), 8-3 | Fenway Park (3-4) | 53-40 | Lost 5 |
| » Starters: Howie Judson vs Leo Kiely | Fourth | 3½ out |
| Wednesday, July 25 |
| » Defeated Red Sox (55-36), 6-2 | Fenway Park (4-4) | 54-40 | |
| » Starters: Ken Holcombe vs Mel Parnell | Fourth | 3½ out |
| Thursday, July 26 |
| » Lost to Red Sox (56-36), 13-10 | Fenway Park (4-5) | 54-41 | |
| » Starters: Joe Dobson vs Willard Nixon | Fourth | 3½ out |
| » Major-league debuts: Bud Sheely (White Sox) |
| Friday, July 27 |
| » Lost to Yankees (56-35), 3-1 | Yankee Stadium (3-3) | 54-42 | Lost 2 |
| » Starters: Billy Pierce vs Tom Morgan | Third | 4½ out |
| Sunday, July 29 |
| » Lost to Yankees (57-35), 8-3 | Yankee Stadium (3-4) | 54-43 | Lost 3 |
| » Starters: Lou Kretlow vs Vic Raschi | Third | 6½ out |
| » Lost to Yankees (58-35), 2-0 | Yankee Stadium (3-5) | 54-44 | Lost 4 |
| » Starters: Saul Rogovin vs Bob Kuzava | Third | 6½ out |
| Future White Sox Ken Kravec is born in Cleveland, OH. |
| Tuesday, July 31 |
| » Lost to Athletics (39-60), 4-2 | Shibe Park (3-4) | 54-45 | Lost 5 |
| » Starters: Ken Holcombe vs Alex Kellner | Fourth | 7½ out |
| Wednesday, August 1 |
| » Defeated Athletics (39-61), 4-3 | Shibe Park (4-4) | 55-45 | |
| » Starters: Billy Pierce vs Morrie Martin | Fourth | 7 out |
| Thursday, August 2 |
| » Defeated Athletics (39-62), 4-3 | Shibe Park (5-4) | 56-45 | Won 2 |
| » Starters: Randy Gumpert vs Bob Hooper | Third | 6 out |
| Friday, August 3 |
| » Defeated Senators (44-56), 7-4 | Griffith Stadium (7-0) | 57-45 | Won 3 |
| » Starters: Saul Rogovin vs Sid Hudson | Third | 5½ out |
| Saturday, August 4 |
| » Lost to Senators (45-56), 5-0 | Griffith Stadium (7-1) | 57-46 | |
| » Starters: Ken Holcombe vs Connie Marrero | Fourth | 6½ out |
| Sunday, August 5 |
| » Defeated Senators (45-57), 6-5 | Griffith Stadium (8-1) | 58-46 | |
| » Starters: Lou Kretlow vs Dick Starr | Fourth | 7 out |
| Monday, August 6 |
| » Defeated Tigers (48-53), 10-1 | Tiger Stadium (3-3) | 59-46 | Won 2 |
| » Starters: Joe Dobson vs Hal White | Fourth | 7 out |
| Tuesday, August 7 |
| » Defeated Tigers (48-54), 2-1 | Tiger Stadium (4-3) | 60-46 | Won 3 |
| » Starters: Billy Pierce vs Ted Gray | Fourth | 6½ out |
| Wednesday, August 8 |
| » Lost to Tigers (49-54), 6-5 | Tiger Stadium (4-4) | 60-47 | |
| » Starters: Saul Rogovin vs Fred Hutchinson | Fourth | 7 out |
| Friday, August 10 |
| » Lost to Indians (67-39), 6-4 | Cleveland Stadium (4-2) | 60-48 | Lost 2 |
| » Starters: Ken Holcombe vs Bob Lemon | Third | 8 out |
| Saturday, August 11 |
| » Lost to Indians (68-39), 2-1 | Cleveland Stadium (4-3) | 60-49 | Lost 3 |
| » Starters: Joe Dobson vs Early Wynn | Third | 9 out |
| Sunday, August 12 |
| » Lost to Indians (69-39), 7-1 | Cleveland Stadium (4-4) | 60-50 | Lost 4 |
| » Starters: Billy Pierce vs Mike Garcia | Fourth | 10 out |
| Wednesday, August 15 |
| » Defeated Tigers (51-59), 2-0 | Comiskey Park I (28-26) | 61-50 | |
| » Starters: Virgil Trucks vs Saul Rogovin | Fourth | 11 out |
| Thursday, August 16 |
| » Lost to Tigers (52-59), 2-1 | Comiskey Park I (28-27) | 61-51 | |
| » Starters: Dizzy Trout vs Joe Dobson | Fourth | 11 out |
| Friday, August 17 |
| » Defeated Indians (72-41), 7-1 | Comiskey Park I (29-27) | 62-51 | |
| » Starters: Bob Feller vs Billy Pierce | Third | 9 out |
| » Defeated Indians (72-42), 8-3 | Comiskey Park I (30-27) | 63-51 | Won 2 |
| » Starters: Bob Chakales vs Randy Gumpert | Third | 9 out |
| Saturday, August 18 |
| » Lost to Indians (73-42), 7-0 | Comiskey Park I (30-28) | 63-52 | |
| » Starters: Bob Lemon vs Ken Holcombe | Third | 10 out |
| Sunday, August 19 |
| » Lost to Indians (74-42), 4-0 | Comiskey Park I (30-29) | 63-53 | Lost 2 |
| » Starters: Early Wynn vs Howie Judson | Fourth | 10 out |
| » Defeated Indians (74-43), 7-6 | Comiskey Park I (31-29) | 64-53 | |
| » Starters: Steve Gromek vs Lou Kretlow | Fourth | 10 out |
| Tuesday, August 21 |
| » Defeated Athletics (46-74), 13-5 | Comiskey Park I (32-29) | 65-53 | Won 2 |
| » Starters: Bobby Shantz vs Saul Rogovin | Fourth | 10½ out |
| Wednesday, August 22 |
| » Lost to Athletics (47-74), 5-2 | Comiskey Park I (32-30) | 65-54 | |
| » Starters: Bob Hooper vs Billy Pierce | Fourth | 12 out |
| » Lost to Athletics (48-74), 8-1 | Comiskey Park I (32-31) | 65-55 | Lost 2 |
| » Starters: Sam Zoldak vs Joe Dobson | Fourth | 12 out |
| Thursday, August 23 |
| » Lost to Athletics (49-74), 6-3 | Comiskey Park I (32-32) | 65-56 | Lost 3 |
| » Starters: Dick Fowler vs Randy Gumpert | Fourth | 13 out |
| Friday, August 24 |
| » Defeated Red Sox (72-48), 3-2 | Comiskey Park I (33-32) | 66-56 | |
| » Starters: Ray Scarborough vs Lou Kretlow | Fourth | 12 out |
| Saturday, August 25 |
| » Defeated Red Sox (72-49), 6-2 | Comiskey Park I (34-32) | 67-56 | Won 2 |
| » Starters: Willard Nixon vs Ken Holcombe | Fourth | 11 out |
| Sunday, August 26 |
| » Defeated Yankees (77-47), 3-2 | Comiskey Park I (35-32) | 68-56 | Won 3 |
| » Starters: Tom Morgan vs Saul Rogovin | Fourth | 11 out |
| » Lost to Yankees (78-47), 8-6 | Comiskey Park I (35-33) | 68-57 | |
| » Starters: Art Schallock vs Billy Pierce | Fourth | 11 out |
| Tuesday, August 28 |
| » Defeated Senators (52-72), 4-3 | Comiskey Park I (36-33) | 69-57 | |
| » Starters: Bob Porterfield vs Harry Dorish | Fourth | 11 out |
| Wednesday, August 29 |
| » Lost to Senators (53-72), 2-1 | Comiskey Park I (36-34) | 69-58 | |
| » Starters: Connie Marrero vs Lou Kretlow | Third | 11 out |
| Friday, August 31 |
| » Defeated Tigers (59-69), 2-0 | Tiger Stadium (5-4) | 70-58 | |
| » Starters: Saul Rogovin vs Marlin Stuart | Fourth | 10½ out |
| Saturday, September 1 |
| » Defeated Tigers (59-70), 4-1 | Tiger Stadium (6-4) | 71-58 | Won 2 |
| » Starters: Ken Holcombe vs Fred Hutchinson | Fourth | 10½ out |
| Sunday, September 2 |
| » Lost to Tigers (60-70), 1-0 | Tiger Stadium (6-5) | 71-59 | |
| » Starters: Billy Pierce vs Virgil Trucks | Fourth | 11 out |
| Monday, September 3 |
| » Lost to Indians (83-49), 5-3 | Cleveland Stadium (4-5) | 71-60 | Lost 2 |
| » Starters: Lou Kretlow vs Bob Feller | Fourth | 12½ out |
| » Lost to Indians (84-49), 6-1 | Cleveland Stadium (4-6) | 71-61 | Lost 3 |
| » Starters: Harry Dorish vs Steve Gromek | Fourth | 12½ out |
| » Major-league debuts: Ross Grimsley (White Sox) |
| Future White Sox Alan Bannister is born in Montebello, CA. |
| Tuesday, September 4 |
| » Defeated Indians (84-50), 3-1 | Cleveland Stadium (5-6) | 72-61 | |
| » Starters: Saul Rogovin vs Bob Lemon | Fourth | 11½ out |
| Thursday, September 6 |
| » Defeated Browns (40-90), 9-4 | Sportsman's Park III (6-1) | 73-61 | Won 2 |
| » Starters: Randy Gumpert vs Jim McDonald | Fourth | 11½ out |
| Friday, September 7 |
| » Lost to Tigers (62-72), 4-1 | Comiskey Park I (36-35) | 73-62 | |
| » Starters: Ted Gray vs Ken Holcombe | Fourth | 12 out |
| » Lost to Tigers (63-72), 2-1 | Comiskey Park I (36-36) | 73-63 | Lost 2 |
| » Starters: Virgil Trucks vs Billy Pierce | Fourth | 12 out |
| Saturday, September 8 |
| » Defeated Tigers (63-73), 3-2 | Comiskey Park I (37-36) | 74-63 | |
| » Starters: Fred Hutchinson vs Lou Kretlow | Fourth | 12 out |
| » Major-league debuts: Bob Boyd (White Sox) |
| Sunday, September 9 |
| » Defeated Tigers (63-74), 4-3 | Comiskey Park I (38-36) | 75-63 | Won 2 |
| » Starters: Wayne McLeland vs Saul Rogovin | Fourth | 12½ out |
| Tuesday, September 11 |
| » Lost to Senators (54-81), 7-6 | Griffith Stadium (8-2) | 75-64 | |
| » Starters: Howie Judson vs Connie Marrero | Fourth | 13 out |
| Wednesday, September 12 |
| » Defeated Senators (54-82), 3-0 | Griffith Stadium (9-2) | 76-64 | |
| » Starters: Billy Pierce vs Sid Hudson | Fourth | 12½ out |
| Friday, September 14 |
| » Lost to Athletics (61-81), 3-0 | Shibe Park (5-5) | 76-65 | |
| » Starters: Lou Kretlow vs Bobby Shantz | Fourth | 12½ out |
| Saturday, September 15 |
| » Lost to Athletics (62-81), 5-4 | Shibe Park (5-6) | 76-66 | Lost 2 |
| » Starters: Randy Gumpert vs Dick Fowler | Fourth | 13 out |
| Sunday, September 16 |
| » Lost to Red Sox (85-55), 5-4 | Fenway Park (4-6) | 76-67 | Lost 3 |
| » Starters: Ken Holcombe vs Leo Kiely | Fourth | 13 out |
| Monday, September 17 |
| » Lost to Red Sox (86-55), 12-5 | Fenway Park (4-7) | 76-68 | Lost 4 |
| » Starters: Howie Judson vs Ray Scarborough | Fourth | 14 out |
| Tuesday, September 18 |
| » Defeated Yankees (89-54), 7-1 | Yankee Stadium (4-5) | 77-68 | |
| » Starters: Billy Pierce vs Vic Raschi | Fourth | 13 out |
| » Major-league debuts: Archie Wilson (Yankees) |
| Wednesday, September 19 |
| » Lost to Yankees (90-54), 5-3 | Yankee Stadium (4-6) | 77-69 | |
| » Starters: Lou Kretlow vs Tom Morgan | Fourth | 14 out |
| Thursday, September 20 |
| » Lost to Yankees (91-54), 5-4 | Yankee Stadium (4-7) | 77-70 | Lost 2 |
| » Starters: Saul Rogovin vs Johnny Sain | Fourth | 15 out |
| Saturday, September 22 |
| » Lost to Browns (48-98), 5-1 | Comiskey Park I (38-37) | 77-71 | Lost 3 |
| » Starters: Ned Garver vs Ken Holcombe | Fourth | 15½ out |
| » Major-league debuts: Red Wilson (White Sox) |
| Sunday, September 23 |
| » Lost to Browns (49-98), 8-7 | Comiskey Park I (38-38) | 77-72 | Lost 4 |
| » Starters: Satchel Paige vs Lou Kretlow | Fourth | 16½ out |
| Tuesday, September 25 |
| » Defeated Indians (92-60), 4-2 | Comiskey Park I (39-38) | 78-72 | |
| » Starters: Early Wynn vs Billy Pierce | Fourth | 16 out |
| Thursday, September 27 |
| » Major-league debuts: Jim Dyck (Browns) |
| Friday, September 28 |
| » Defeated Browns (51-100), 6-2 | Sportsman's Park III (7-1) | 79-72 | Won 2 |
| » Starters: Ken Holcombe vs Bob Mahoney | Fourth | 15½ out |
| » Defeated Browns (51-101), 4-3 | Sportsman's Park III (8-1) | 80-72 | Won 3 |
| » Starters: Howie Judson vs Duane Pillette | Fourth | 15½ out |
| Saturday, September 29 |
| » Defeated Browns (51-102), 8-3 | Sportsman's Park III (9-1) | 81-72 | Won 4 |
| » Starters: Lou Kretlow vs Bob Turley | Fourth | 16 out |
| Sunday, September 30 |
| » Lost to Browns (52-102), 9-5 | Sportsman's Park III (9-2) | 81-73 | |
| » Starters: Joe Dobson vs Ned Garver | Fourth | 17 out |
| Tuesday, October 2 |
| Future White Sox Bob Coluccio is born in Centralia, WA. |
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