| Friday, January 26 |
| Former Senator Bill Barrett dies in Cambridge, MA at the age of 51. |
| Wednesday, March 7 |
| Future Senator Jeff Burroughs is born in Long Beach, CA. |
| Saturday, April 14 |
| Former Senator Danny Moeller dies in Florence, AL at the age of 67. |
| Tuesday, April 17 |
| » Defeated Athletics (0-1), 6-1 | Shibe Park (1-0) | 1-0 | |
| » Starters: Connie Marrero vs Bobby Shantz | First | -- |
| Wednesday, April 18 |
| » Defeated Athletics (0-2), 6-4 | Shibe Park (2-0) | 2-0 | Won 2 |
| » Starters: Bob Kuzava vs Lou Brissie | First | -- |
| Friday, April 20 |
| » Defeated Yankees (2-1), 5-3 | Griffith Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Tommy Byrne vs Sandy Consuegra | First | -- |
| » Defeated Yankees (2-2), 8-4 | Griffith Stadium (2-0) | 4-0 | Won 4 |
| » Starters: Tom Morgan vs Al Sima | First | -- |
| » Major-league debuts: Gil McDougald and Tom Morgan (Yankees) |
| Saturday, April 21 |
| » Lost to Yankees (3-2), 8-7 | Griffith Stadium (2-1) | 4-1 | |
| » Starters: Spec Shea vs Gene Bearden | First | -- |
| Tuesday, April 24 |
| » Defeated Red Sox (3-4), 7-5 | Fenway Park (1-0) | 5-1 | |
| » Starters: Bob Kuzava vs Bill Wight | Second | ½ out |
| Thursday, April 26 |
| » Defeated Athletics (1-9), 2-1 | Griffith Stadium (3-1) | 6-1 | Won 2 |
| » Starters: Joe Coleman vs Connie Marrero | First | -- |
| Friday, April 27 |
| » Defeated Athletics (1-10), 6-1 | Griffith Stadium (4-1) | 7-1 | Won 3 |
| » Starters: Carl Scheib vs Sandy Consuegra | First | -- |
| Saturday, April 28 |
| » Lost to Yankees (7-4), 6-4 | Yankee Stadium (0-1) | 7-2 | |
| » Starters: Al Sima vs Tom Morgan | Second | ½ out |
| Sunday, April 29 |
| » Lost to Yankees (8-4), 4-0 | Yankee Stadium (0-2) | 7-3 | Lost 2 |
| » Starters: Bob Kuzava vs Ed Lopat | First | -- |
| Monday, April 30 |
| » Major-league debuts: Earl Mossor (Dodgers) |
| Tuesday, May 1 |
| » Defeated Browns (4-9), 9-8 | Sportsman's Park III (1-0) | 8-3 | |
| » Starters: Joe Haynes vs Bill Kennedy | First | -- |
| Wednesday, May 2 |
| » Defeated Browns (4-10), 8-1 | Sportsman's Park III (2-0) | 9-3 | Won 2 |
| » Starters: Sandy Consuegra vs Lou Sleater | First | -- |
| Thursday, May 3 |
| » Defeated White Sox (6-7), 7-1 | Comiskey Park I (1-0) | 10-3 | Won 3 |
| » Starters: Connie Marrero vs Billy Pierce | First | -- |
| Friday, May 4 |
| » Lost to White Sox (7-7), 6-5 | Comiskey Park I (1-1) | 10-4 | |
| » Starters: Al Sima vs Joe Dobson | Second | 1 out |
| Saturday, May 5 |
| » Lost to White Sox (8-7), 7-0 | Comiskey Park I (1-2) | 10-5 | Lost 2 |
| » Starters: Bob Kuzava vs Bob Cain | Third | 2 out |
| Sunday, May 6 |
| » Defeated Indians (10-5), 8-1 | Cleveland Stadium (1-0) | 11-5 | |
| » Starters: Julio Moreno vs Lou Brissie | Third | 2½ out |
| » Lost to Indians (11-5), 4-2 | Cleveland Stadium (1-1) | 11-6 | |
| » Starters: Bob Ross vs Bob Chakales | Third | 2½ out |
| » Major-league debuts: Willie Miranda (Senators) |
| Monday, May 7 |
| » Defeated Indians (11-6), 11-10 | Cleveland Stadium (2-1) | 12-6 | |
| » Starters: Sandy Consuegra vs Johnny Vander Meer | Second | 1½ out |
| Wednesday, May 9 |
| » Lost to Tigers (9-8), 4-0 | Tiger Stadium (0-1) | 12-7 | |
| » Starters: Al Sima vs Hal Newhouser | Second | 2 out |
| Saturday, May 12 |
| » Defeated Red Sox (10-10), 5-4 | Griffith Stadium (5-1) | 13-7 | |
| » Starters: Chuck Stobbs vs Connie Marrero | Second | 2 out |
| Sunday, May 13 |
| » Lost to Red Sox (11-10), 10-1 | Griffith Stadium (5-2) | 13-8 | |
| » Starters: Mel Parnell vs Bob Kuzava | Second | 1½ out |
| Monday, May 14 |
| » Lost to Red Sox (12-10), 8-7 | Griffith Stadium (5-3) | 13-9 | Lost 2 |
| » Starters: Bill Wight vs Julio Moreno | Second | 2½ out |
| Tuesday, May 15 |
| » Lost to Tigers (13-9), 12-4 | Griffith Stadium (5-4) | 13-10 | Lost 3 |
| » Starters: Hal Newhouser vs Sandy Consuegra | Third | 3 out |
| Wednesday, May 16 |
| » Lost to Tigers (14-9), 7-1 | Griffith Stadium (5-5) | 13-11 | Lost 4 |
| » Starters: Dizzy Trout vs Al Sima | Third | 4 out |
| Thursday, May 17 |
| » Defeated Tigers (14-10), 11-6 | Griffith Stadium (6-5) | 14-11 | |
| » Starters: Fred Hutchinson vs Connie Marrero | Fourth | 4 out |
| Friday, May 18 |
| » Defeated Browns (8-21), 6-2 | Griffith Stadium (7-5) | 15-11 | Won 2 |
| » Starters: Lou Sleater vs Bob Kuzava | Fourth | 3 out |
| Sunday, May 20 |
| » Lost to White Sox (16-9), 5-4 | Griffith Stadium (7-6) | 15-12 | |
| » Starters: Ken Holcombe vs Sandy Consuegra | Fourth | 4 out |
| Monday, May 21 |
| » Lost to White Sox (17-9), 5-3 | Griffith Stadium (7-7) | 15-13 | Lost 2 |
| » Starters: Joe Dobson vs Julio Moreno | Fourth | 5 out |
| Tuesday, May 22 |
| » Lost to White Sox (18-9), 9-8 | Griffith Stadium (7-8) | 15-14 | Lost 3 |
| » Starters: Saul Rogovin vs Bob Kuzava | Fifth | 6 out |
| Thursday, May 24 |
| » Lost to Indians (15-15), 16-0 | Griffith Stadium (7-9) | 15-15 | Lost 4 |
| » Starters: Bob Feller vs Sid Hudson | Fifth | 7 out |
| Friday, May 25 |
| » Lost to Red Sox (18-13), 14-2 | Fenway Park (1-1) | 15-16 | Lost 5 |
| » Starters: Connie Marrero vs Chuck Stobbs | Fifth | 8 out |
| Saturday, May 26 |
| » Lost to Red Sox (19-13), 11-1 | Fenway Park (1-2) | 15-17 | Lost 6 |
| » Starters: Sandy Consuegra vs Willard Nixon | Fifth | 9 out |
| Sunday, May 27 |
| » Lost to Red Sox (20-13), 9-3 | Fenway Park (1-3) | 15-18 | Lost 7 |
| » Starters: Al Sima vs Mickey McDermott | Fifth | 10 out |
| » Lost to Red Sox (21-13), 7-1 | Fenway Park (1-4) | 15-19 | Lost 8 |
| » Starters: Julio Moreno vs Harry Taylor | Fifth | 10 out |
| Wednesday, May 30 |
| » Lost to Athletics (11-26), 9-5 | Griffith Stadium (7-10) | 15-20 | Lost 9 |
| » Starters: Joe Coleman vs Sid Hudson | Sixth | 10½ out |
| » Defeated Athletics (11-27), 6-2 | Griffith Stadium (8-10) | 16-20 | |
| » Starters: Alex Kellner vs Connie Marrero | Sixth | 10½ out |
| Friday, June 1 |
| » Lost to Indians (20-19), 2-1 | Cleveland Stadium (2-2) | 16-21 | |
| » Starters: Julio Moreno vs Early Wynn | Sixth | 11 out |
| Saturday, June 2 |
| » Lost to Indians (21-19), 12-4 | Cleveland Stadium (2-3) | 16-22 | Lost 2 |
| » Starters: Sandy Consuegra vs Lou Brissie | Sixth | 11 out |
| Sunday, June 3 |
| » Defeated Tigers (17-22), 8-4 | Tiger Stadium (1-1) | 17-22 | |
| » Starters: Al Sima vs Dizzy Trout | Sixth | 11 out |
| » Lost to Tigers (18-22), 10-2 | Tiger Stadium (1-2) | 17-23 | |
| » Starters: Sid Hudson vs Fred Hutchinson | Sixth | 11 out |
| Monday, June 4 |
| » Lost to Tigers (19-22), 6-5 | Tiger Stadium (1-3) | 17-24 | Lost 2 |
| » Starters: Hank Wyse vs Hal Newhouser | Sixth | 12½ out |
| Tuesday, June 5 |
| » Lost to Tigers (20-22), 4-0 | Tiger Stadium (1-4) | 17-25 | Lost 3 |
| » Starters: Don Johnson vs Gene Bearden | Sixth | 13½ out |
| Wednesday, June 6 |
| » Lost to White Sox (31-11), 4-2 | Comiskey Park I (1-3) | 17-26 | Lost 4 |
| » Starters: Connie Marrero vs Lou Kretlow | Sixth | 14½ out |
| Thursday, June 7 |
| » Lost to White Sox (32-11), 5-0 | Comiskey Park I (1-4) | 17-27 | Lost 5 |
| » Starters: Julio Moreno vs Harry Dorish | Sixth | 15½ out |
| Saturday, June 9 |
| » Lost to Browns (16-33), 8-7 | Sportsman's Park III (2-1) | 17-28 | Lost 6 |
| » Starters: Hank Wyse vs Bob Mahoney | Fifth | 15 out |
| Sunday, June 10 |
| » Lost to Browns (17-33), 10-9 | Sportsman's Park III (2-2) | 17-29 | Lost 7 |
| » Starters: Bob Kuzava vs Ned Garver | Sixth | 15 out |
| » Defeated Browns (17-34), 3-2 | Sportsman's Park III (3-2) | 18-29 | |
| » Starters: Don Johnson vs Stubby Overmire | Sixth | 15 out |
| Tuesday, June 12 |
| » Lost to White Sox (34-14), 3-0 | Griffith Stadium (8-11) | 18-30 | |
| » Starters: Lou Kretlow vs Connie Marrero | Sixth | 16 out |
| Thursday, June 14 |
| » Lost to White Sox (35-14), 8-7 | Griffith Stadium (8-12) | 18-31 | Lost 2 |
| » Starters: Billy Pierce vs Sid Hudson | Sixth | 18 out |
| » Lost to White Sox (36-14), 14-5 | Griffith Stadium (8-13) | 18-32 | Lost 3 |
| » Starters: Joe Dobson vs Al Sima | Sixth | 18 out |
| Friday, June 15 |
| » Defeated Indians (29-24), 4-2 | Griffith Stadium (9-13) | 19-32 | |
| » Starters: Early Wynn vs Don Johnson | Sixth | 16½ out |
| Saturday, June 16 |
| » Defeated Indians (29-25), 4-3 | Griffith Stadium (10-13) | 20-32 | Won 2 |
| » Starters: Mike Garcia vs Julio Moreno | Sixth | 15½ out |
| Sunday, June 17 |
| » Defeated Indians (29-26), 5-1 | Griffith Stadium (11-13) | 21-32 | Won 3 |
| » Starters: Bob Chakales vs Fred Sanford | Sixth | 16 out |
| Tuesday, June 19 |
| » Lost to Browns (19-37), 4-1 | Griffith Stadium (11-14) | 21-33 | |
| » Starters: Duane Pillette vs Connie Marrero | Sixth | 16½ out |
| Wednesday, June 20 |
| » Defeated Browns (19-38), 5-1 | Griffith Stadium (12-14) | 22-33 | |
| » Starters: Lou Sleater vs Sid Hudson | Sixth | 15½ out |
| Thursday, June 21 |
| » Defeated Browns (19-39), 9-2 | Griffith Stadium (13-14) | 23-33 | Won 2 |
| » Starters: Jim Suchecki vs Don Johnson | Sixth | 15½ out |
| Friday, June 22 |
| » Lost to Tigers (29-28), 7-3 | Griffith Stadium (13-15) | 23-34 | |
| » Starters: Ted Gray vs Fred Sanford | Sixth | 15½ out |
| Saturday, June 23 |
| » Defeated Tigers (29-29), 6-3 | Griffith Stadium (14-15) | 24-34 | |
| » Starters: Dizzy Trout vs Bob Porterfield | Sixth | 14½ out |
| Sunday, June 24 |
| » Lost to Tigers (30-29), 10-5 | Griffith Stadium (14-16) | 24-35 | |
| » Starters: Virgil Trucks vs Julio Moreno | Sixth | 15 out |
| Tuesday, June 26 |
| » Defeated Yankees (39-23), 7-3 | Griffith Stadium (15-16) | 25-35 | |
| » Starters: Ed Lopat vs Connie Marrero | Sixth | 15 out |
| Wednesday, June 27 |
| » Lost to Yankees (40-23), 2-0 | Griffith Stadium (15-17) | 25-36 | |
| » Starters: Allie Reynolds vs Don Johnson | Sixth | 15 out |
| Thursday, June 28 |
| » Lost to Yankees (41-23), 3-0 | Griffith Stadium (15-18) | 25-37 | Lost 2 |
| » Starters: Tom Morgan vs Sid Hudson | Sixth | 15½ out |
| Friday, June 29 |
| » Lost to Athletics (25-41), 3-2 | Shibe Park (2-1) | 25-38 | Lost 3 |
| » Starters: Bob Porterfield vs Sam Zoldak | Sixth | 17 out |
| » Lost to Athletics (26-41), 11-5 | Shibe Park (2-2) | 25-39 | Lost 4 |
| » Starters: Fred Sanford vs Alex Kellner | Sixth | 17 out |
| Sunday, July 1 |
| » Lost to Athletics (27-41), 10-7 | Shibe Park (2-3) | 25-40 | Lost 5 |
| » Starters: Don Johnson vs Dick Fowler | Seventh | 17½ out |
| » Lost to Athletics (28-41), 3-2 | Shibe Park (2-4) | 25-41 | Lost 6 |
| » Starters: Julio Moreno vs Bob Hooper | Seventh | 17½ out |
| » Major-league debuts: Pete Runnels (Senators) |
| Monday, July 2 |
| » Lost to Red Sox (41-28), 5-2 | Griffith Stadium (15-19) | 25-42 | Lost 7 |
| » Starters: Leo Kiely vs Connie Marrero | Seventh | 18½ out |
| Tuesday, July 3 |
| » Defeated Red Sox (41-29), 4-1 | Griffith Stadium (16-19) | 26-42 | |
| » Starters: Ray Scarborough vs Sid Hudson | Seventh | 18 out |
| Wednesday, July 4 |
| » Defeated Yankees (44-25), 9-6 | Yankee Stadium (1-2) | 27-42 | Won 2 |
| » Starters: Fred Sanford vs Vic Raschi | Sixth | 16½ out |
| » Defeated Yankees (44-26), 6-5 | Yankee Stadium (2-2) | 28-42 | Won 3 |
| » Starters: Joe Haynes vs Tom Morgan | Sixth | 16½ out |
| Thursday, July 5 |
| » Lost to Yankees (45-26), 8-2 | Yankee Stadium (2-3) | 28-43 | |
| » Starters: Bob Porterfield vs Bob Kuzava | Sixth | 17 out |
| Friday, July 6 |
| » Defeated Athletics (28-46), 6-3 | Griffith Stadium (17-19) | 29-43 | |
| » Starters: Bobby Shantz vs Don Johnson | Sixth | 16 out |
| Saturday, July 7 |
| » Lost to Athletics (29-46), 4-3 | Griffith Stadium (17-20) | 29-44 | |
| » Starters: Dick Fowler vs Julio Moreno | Sixth | 17 out |
| Sunday, July 8 |
| » Defeated Athletics (29-47), 3-1 | Griffith Stadium (18-20) | 30-44 | |
| » Starters: Alex Kellner vs Connie Marrero | Sixth | 16½ out |
| » Defeated Athletics (29-48), 8-2 | Griffith Stadium (19-20) | 31-44 | Won 2 |
| » Starters: Carl Scheib vs Sid Hudson | Sixth | 16½ out |
| Thursday, July 12 |
| » Lost to Tigers (35-38), 5-4 | Tiger Stadium (1-5) | 31-45 | |
| » Starters: Fred Sanford vs Bob Cain | Sixth | 17 out |
| Friday, July 13 |
| » Defeated Tigers (35-39), 3-1 | Tiger Stadium (2-5) | 32-45 | |
| » Starters: Bob Porterfield vs Ted Gray | Sixth | 16 out |
| Saturday, July 14 |
| » Defeated Tigers (35-40), 8-0 | Tiger Stadium (3-5) | 33-45 | Won 2 |
| » Starters: Don Johnson vs Hal Newhouser | Sixth | 16 out |
| Sunday, July 15 |
| » Defeated Indians (46-34), 7-4 | Cleveland Stadium (3-3) | 34-45 | Won 3 |
| » Starters: Connie Marrero vs Bob Chakales | Sixth | 16 out |
| » Lost to Indians (47-34), 7-2 | Cleveland Stadium (3-4) | 34-46 | |
| » Starters: Sid Hudson vs Mike Garcia | Sixth | 16 out |
| Monday, July 16 |
| » Lost to Indians (48-34), 8-2 | Cleveland Stadium (3-5) | 34-47 | Lost 2 |
| » Starters: Julio Moreno vs Steve Gromek | Sixth | 16 out |
| Tuesday, July 17 |
| » Defeated Browns (25-57), 7-2 | Sportsman's Park III (4-2) | 35-47 | |
| » Starters: Sandy Consuegra vs Duane Pillette | Sixth | 15½ out |
| » Lost to Browns (26-57), 2-0 | Sportsman's Park III (4-3) | 35-48 | |
| » Starters: Fred Sanford vs Tommy Byrne | Sixth | 15½ out |
| Wednesday, July 18 |
| » Defeated Browns (26-58), 7-1 | Sportsman's Park III (5-3) | 36-48 | |
| » Starters: Bob Porterfield vs Satchel Paige | Sixth | 15½ out |
| Thursday, July 19 |
| » Lost to Browns (27-58), 9-7 | Sportsman's Park III (5-4) | 36-49 | |
| » Starters: Don Johnson vs Dick Starr | Sixth | 15½ out |
| Former Senator Sam Agnew dies in Sonoma, CA at the age of 65. |
| Friday, July 20 |
| » Defeated White Sox (53-36), 2-1 | Comiskey Park I (2-4) | 37-49 | |
| » Starters: Sid Hudson vs Lou Kretlow | Sixth | 14½ out |
| Saturday, July 21 |
| » Defeated White Sox (53-37), 10-5 | Comiskey Park I (3-4) | 38-49 | Won 2 |
| » Starters: Julio Moreno vs Randy Gumpert | Sixth | 14½ out |
| Sunday, July 22 |
| » Defeated White Sox (53-38), 7-6 | Comiskey Park I (4-4) | 39-49 | Won 3 |
| » Starters: Connie Marrero vs Saul Rogovin | Fifth | 14 out |
| » Defeated White Sox (53-39), 11-5 | Comiskey Park I (5-4) | 40-49 | Won 4 |
| » Starters: Fred Sanford vs Ken Holcombe | Fifth | 14 out |
| Tuesday, July 24 |
| » Lost to Tigers (40-46), 2-1 | Griffith Stadium (19-21) | 40-50 | |
| » Starters: Marlin Stuart vs Bob Porterfield | Sixth | 15 out |
| Wednesday, July 25 |
| » Defeated Tigers (40-47), 7-4 | Griffith Stadium (20-21) | 41-50 | |
| » Starters: Fred Hutchinson vs Don Johnson | Sixth | 15 out |
| Thursday, July 26 |
| » Lost to Tigers (41-47), 6-3 | Griffith Stadium (20-22) | 41-51 | |
| » Starters: Bob Cain vs Sid Hudson | Sixth | 15 out |
| Friday, July 27 |
| » Defeated Browns (29-63), 7-0 | Griffith Stadium (21-22) | 42-51 | |
| » Starters: Jim McDonald vs Connie Marrero | Fifth | 15 out |
| Sunday, July 29 |
| » Defeated Browns (29-64), 7-2 | Griffith Stadium (22-22) | 43-51 | Won 2 |
| » Starters: Al Widmar vs Sandy Consuegra | Fifth | 16 out |
| » Lost to Browns (30-64), 8-6 | Griffith Stadium (22-23) | 43-52 | |
| » Starters: Tommy Byrne vs Bob Porterfield | Fifth | 16 out |
| » Major-league debuts: Ben Taylor (Browns) |
| Tuesday, July 31 |
| » Lost to Indians (58-38), 5-3 | Griffith Stadium (22-24) | 43-53 | Lost 2 |
| » Starters: Bob Feller vs Don Johnson | Sixth | 17 out |
| Wednesday, August 1 |
| » Lost to Indians (59-38), 8-6 | Griffith Stadium (22-25) | 43-54 | Lost 3 |
| » Starters: Bob Lemon vs Dick Starr | Sixth | 17 out |
| » Defeated Indians (59-39), 4-3 | Griffith Stadium (23-25) | 44-54 | |
| » Starters: Early Wynn vs Julio Moreno | Sixth | 17 out |
| Thursday, August 2 |
| » Lost to Indians (60-39), 5-2 | Griffith Stadium (23-26) | 44-55 | |
| » Starters: Steve Gromek vs Bob Porterfield | Fifth | 17 out |
| Friday, August 3 |
| » Lost to White Sox (57-45), 7-4 | Griffith Stadium (23-27) | 44-56 | Lost 2 |
| » Starters: Saul Rogovin vs Sid Hudson | Fifth | 17½ out |
| Saturday, August 4 |
| » Defeated White Sox (57-46), 5-0 | Griffith Stadium (24-27) | 45-56 | |
| » Starters: Ken Holcombe vs Connie Marrero | Sixth | 17½ out |
| Sunday, August 5 |
| » Lost to White Sox (58-46), 6-5 | Griffith Stadium (24-28) | 45-57 | |
| » Starters: Lou Kretlow vs Dick Starr | Sixth | 19 out |
| Monday, August 6 |
| » Lost to Yankees (65-38), 4-0 | Yankee Stadium (2-4) | 45-58 | Lost 2 |
| » Starters: Don Johnson vs Tom Morgan | Sixth | 20 out |
| Wednesday, August 8 |
| » Defeated Yankees (65-39), 4-1 | Yankee Stadium (3-4) | 46-58 | |
| » Starters: Bob Porterfield vs Vic Raschi | Sixth | 19½ out |
| Thursday, August 9 |
| » Lost to Yankees (66-39), 6-4 | Yankee Stadium (3-5) | 46-59 | |
| » Starters: Julio Moreno vs Bob Kuzava | Fifth | 20 out |
| Friday, August 10 |
| » Lost to Red Sox (63-44), 6-4 | Fenway Park (1-5) | 46-60 | Lost 2 |
| » Starters: Connie Marrero vs Mel Parnell | Fifth | 21 out |
| Saturday, August 11 |
| » Defeated Red Sox (63-45), 7-1 | Fenway Park (2-5) | 47-60 | |
| » Starters: Dick Starr vs Chuck Stobbs | Fifth | 21 out |
| Sunday, August 12 |
| » Lost to Red Sox (64-45), 6-2 | Fenway Park (2-6) | 47-61 | |
| » Starters: Don Johnson vs Ray Scarborough | Sixth | 22½ out |
| » Lost to Red Sox (65-45), 6-2 | Fenway Park (2-7) | 47-62 | Lost 2 |
| » Starters: Sid Hudson vs Bill Wight | Sixth | 22½ out |
| Tuesday, August 14 |
| » Lost to Yankees (69-42), 6-3 | Griffith Stadium (24-29) | 47-63 | Lost 3 |
| » Starters: Tom Morgan vs Bob Porterfield | Sixth | 24 out |
| Wednesday, August 15 |
| » Lost to Yankees (70-42), 8-5 | Griffith Stadium (24-30) | 47-64 | Lost 4 |
| » Starters: Ed Lopat vs Julio Moreno | Sixth | 25 out |
| Thursday, August 16 |
| » Lost to Yankees (71-42), 5-3 | Griffith Stadium (24-31) | 47-65 | Lost 5 |
| » Starters: Art Schallock vs Dick Starr | Sixth | 25 out |
| Friday, August 17 |
| » Lost to Red Sox (68-46), 7-4 | Griffith Stadium (24-32) | 47-66 | Lost 6 |
| » Starters: Bill Wight vs Connie Marrero | Fifth | 24½ out |
| Saturday, August 18 |
| » Lost to Red Sox (69-46), 10-9 | Griffith Stadium (24-33) | 47-67 | Lost 7 |
| » Starters: Leo Kiely vs Don Johnson | Fifth | 25½ out |
| Sunday, August 19 |
| » Lost to Red Sox (70-46), 8-3 | Griffith Stadium (24-34) | 47-68 | Lost 8 |
| » Starters: Chuck Stobbs vs Bob Porterfield | Sixth | 26 out |
| Monday, August 20 |
| » Lost to Indians (75-43), 5-3 | Cleveland Stadium (3-6) | 47-69 | Lost 9 |
| » Starters: Dick Starr vs Mike Garcia | Sixth | 27 out |
| Tuesday, August 21 |
| » Lost to Indians (76-43), 6-0 | Cleveland Stadium (3-7) | 47-70 | Lost 10 |
| » Starters: Don Johnson vs Bob Feller | Sixth | 28 out |
| Wednesday, August 22 |
| » Lost to Indians (77-43), 6-5 | Cleveland Stadium (3-8) | 47-71 | Lost 11 |
| » Starters: Julio Moreno vs Bob Chakales | Sixth | 29 out |
| Thursday, August 23 |
| » Defeated Tigers (57-63), 10-0 | Tiger Stadium (4-5) | 48-71 | |
| » Starters: Bob Porterfield vs Dizzy Trout | Sixth | 29 out |
| Friday, August 24 |
| » Defeated Tigers (57-64), 10-7 | Tiger Stadium (5-5) | 49-71 | Won 2 |
| » Starters: Connie Marrero vs Bob Cain | Sixth | 28 out |
| Saturday, August 25 |
| » Defeated Tigers (57-65), 11-5 | Tiger Stadium (6-5) | 50-71 | Won 3 |
| » Starters: Dick Starr vs Virgil Trucks | Sixth | 27 out |
| Sunday, August 26 |
| » Defeated Browns (38-83), 9-3 | Sportsman's Park III (6-4) | 51-71 | Won 4 |
| » Starters: Sid Hudson vs Jim McDonald | Sixth | 26 out |
| » Defeated Browns (38-84), 9-1 | Sportsman's Park III (7-4) | 52-71 | Won 5 |
| » Starters: Don Johnson vs Bob Mahoney | Sixth | 26 out |
| Tuesday, August 28 |
| » Lost to White Sox (69-57), 4-3 | Comiskey Park I (5-5) | 52-72 | |
| » Starters: Bob Porterfield vs Harry Dorish | Sixth | 27 out |
| Wednesday, August 29 |
| » Defeated White Sox (69-58), 2-1 | Comiskey Park I (6-5) | 53-72 | |
| » Starters: Connie Marrero vs Lou Kretlow | Fifth | 26 out |
| Saturday, September 1 |
| » Lost to Yankees (81-47), 4-0 | Griffith Stadium (24-35) | 53-73 | |
| » Starters: Ed Lopat vs Sid Hudson | Sixth | 27 out |
| Sunday, September 2 |
| » Major-league debuts: Bud Thomas (Browns) |
| Monday, September 3 |
| » Lost to Red Sox (76-51), 3-2 | Fenway Park (2-8) | 53-74 | Lost 2 |
| » Starters: Dick Starr vs Mel Parnell | Sixth | 28½ out |
| » Lost to Red Sox (77-51), 8-4 | Fenway Park (2-9) | 53-75 | Lost 3 |
| » Starters: Bob Porterfield vs Chuck Stobbs | Sixth | 28½ out |
| Wednesday, September 5 |
| » Lost to Athletics (55-78), 4-1 | Shibe Park (2-5) | 53-76 | Lost 4 |
| » Starters: Connie Marrero vs Sam Zoldak | Seventh | 29½ out |
| » Lost to Athletics (56-78), 9-7 | Shibe Park (2-6) | 53-77 | Lost 5 |
| » Starters: Don Johnson vs Bob Hooper | Seventh | 29½ out |
| Friday, September 7 |
| » Lost to Yankees (83-49), 4-2 | Yankee Stadium (3-6) | 53-78 | Lost 6 |
| » Starters: Sid Hudson vs Allie Reynolds | Seventh | 29½ out |
| Saturday, September 8 |
| » Lost to Yankees (84-49), 4-0 | Yankee Stadium (3-7) | 53-79 | Lost 7 |
| » Starters: Bob Porterfield vs Ed Lopat | Seventh | 30½ out |
| Sunday, September 9 |
| » Lost to Yankees (85-49), 7-5 | Yankee Stadium (3-8) | 53-80 | Lost 8 |
| » Starters: Dick Starr vs Johnny Sain | Seventh | 32½ out |
| » Lost to Yankees (86-49), 2-0 | Yankee Stadium (3-9) | 53-81 | Lost 9 |
| » Starters: Don Johnson vs Vic Raschi | Seventh | 32½ out |
| Tuesday, September 11 |
| » Defeated White Sox (75-64), 7-6 | Griffith Stadium (25-35) | 54-81 | |
| » Starters: Howie Judson vs Connie Marrero | Seventh | 32 out |
| Wednesday, September 12 |
| » Lost to White Sox (76-64), 3-0 | Griffith Stadium (25-36) | 54-82 | |
| » Starters: Billy Pierce vs Sid Hudson | Seventh | 32½ out |
| Thursday, September 13 |
| » Defeated Indians (89-53), 1-0 | Griffith Stadium (26-36) | 55-82 | |
| » Starters: Bob Lemon vs Bob Porterfield | Seventh | 31½ out |
| Saturday, September 15 |
| » Lost to Indians (90-53), 4-2 | Griffith Stadium (26-37) | 55-83 | |
| » Starters: Early Wynn vs Don Johnson | Seventh | 31½ out |
| » Defeated Indians (90-54), 7-6 | Griffith Stadium (27-37) | 56-83 | |
| » Starters: Steve Gromek vs Julio Moreno | Seventh | 31½ out |
| Sunday, September 16 |
| » Lost to Tigers (66-77), 3-1 | Griffith Stadium (27-38) | 56-84 | |
| » Starters: Bob Cain vs Dick Starr | Seventh | 32 out |
| » Lost to Tigers (67-77), 4-3 | Griffith Stadium (27-39) | 56-85 | Lost 2 |
| » Starters: Ted Gray vs Connie Marrero | Seventh | 32 out |
| Tuesday, September 18 |
| » Lost to Browns (45-97), 8-0 | Griffith Stadium (27-40) | 56-86 | Lost 3 |
| » Starters: Tommy Byrne vs Sid Hudson | Seventh | 33 out |
| » Lost to Browns (46-97), 3-2 | Griffith Stadium (27-41) | 56-87 | Lost 4 |
| » Starters: Ned Garver vs Sandy Consuegra | Seventh | 33 out |
| Wednesday, September 19 |
| » Defeated Browns (46-98), 4-3 | Griffith Stadium (28-41) | 57-87 | |
| » Starters: Bob Mahoney vs Bob Porterfield | Seventh | 33 out |
| Thursday, September 20 |
| » Lost to Browns (47-98), 4-3 | Griffith Stadium (28-42) | 57-88 | |
| » Starters: Duane Pillette vs Don Johnson | Seventh | 34 out |
| Saturday, September 22 |
| » Defeated Athletics (65-83), 9-1 | Shibe Park (3-6) | 58-88 | |
| » Starters: Dick Starr vs Dick Fowler | Seventh | 33½ out |
| Sunday, September 23 |
| » Lost to Athletics (66-83), 12-4 | Shibe Park (3-7) | 58-89 | |
| » Starters: Connie Marrero vs Bob Hooper | Seventh | 35 out |
| » Lost to Athletics (67-83), 8-3 | Shibe Park (3-8) | 58-90 | Lost 2 |
| » Starters: Sandy Consuegra vs Sam Zoldak | Seventh | 35 out |
| Former Senator Dale Gear dies in Topeka, KS at the age of 80. |
| Tuesday, September 25 |
| » Defeated Red Sox (87-60), 3-0 | Griffith Stadium (29-42) | 59-90 | |
| » Starters: Leo Kiely vs Bob Porterfield | Seventh | 34½ out |
| Wednesday, September 26 |
| » Defeated Red Sox (87-61), 7-3 | Griffith Stadium (30-42) | 60-90 | Won 2 |
| » Starters: Ray Scarborough vs Sid Hudson | Seventh | 33½ out |
| » Major-league debuts: Sammy White (Red Sox) |
| Thursday, September 27 |
| » Defeated Red Sox (87-62), 8-6 | Griffith Stadium (31-42) | 61-90 | Won 3 |
| » Starters: Chuck Stobbs vs Julio Moreno | Seventh | 33 out |
| Saturday, September 29 |
| » Lost to Athletics (69-83), 5-1 | Griffith Stadium (31-43) | 61-91 | |
| » Starters: Alex Kellner vs Dick Starr | Seventh | 35½ out |
| Sunday, September 30 |
| » Defeated Athletics (69-84), 4-2 | Griffith Stadium (32-43) | 62-91 | |
| » Starters: Bobby Shantz vs Bob Porterfield | Seventh | 36 out |
| » Lost to Athletics (70-84), 4-3 | Griffith Stadium (32-44) | 62-92 | |
| » Starters: Bob Hooper vs Joe Haynes | Seventh | 36 out |
Game information provided by Retrosheet (www.retrosheet.org) |
