| Tuesday, January 2 |
| Future Indian Jim Essian is born in Detroit, MI. |
| Tuesday, January 23 |
| Future Indian Charlie Spikes is born in Bogalusa, LA. |
| Thursday, January 25 |
| Future Indian Vern Ruhle is born in Coleman, MI. |
| Wednesday, February 7 |
| Future Indian Benny Ayala is born in Yauco, P.R. |
| Wednesday, February 14 |
| Future Indian Larry Milbourne is born in Port Norris, NJ. |
| Friday, April 6 |
| Future Indian Bert Blyleven is born in Zeist, Holland. |
| Wednesday, April 11 |
| Future Indian Sid Monge is born in Agua Prieta, Mexico. |
| Saturday, April 14 |
| Former Indian Danny Moeller dies in Florence, AL at the age of 67. |
| Tuesday, April 17 |
| » Defeated Tigers (0-1), 2-1 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Bob Lemon vs Hal Newhouser | First | -- |
| Wednesday, April 18 |
| » Defeated Tigers (0-2), 4-2 | Tiger Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Early Wynn vs Dizzy Trout | First | -- |
| Friday, April 20 |
| » Defeated Browns (0-3), 4-1 | Cleveland Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Dick Starr vs Bob Feller | Second | ½ out |
| Saturday, April 21 |
| » Lost to Browns (1-3), 9-1 | Cleveland Stadium (1-1) | 3-1 | |
| » Starters: Ned Garver vs Bob Lemon | Second | ½ out |
| » Major-league debuts: Bob Chakales and George Zuverink (Indians) |
| Sunday, April 22 |
| » Defeated Browns (1-4), 10-3 | Cleveland Stadium (2-1) | 4-1 | |
| » Starters: Stubby Overmire vs Early Wynn | First | -- |
| » Defeated Browns (1-5), 4-3 | Cleveland Stadium (3-1) | 5-1 | Won 2 |
| » Starters: Lou Sleater vs Mike Garcia | First | -- |
| Tuesday, April 24 |
| » Defeated White Sox (4-2), 5-2 | Cleveland Stadium (4-1) | 6-1 | Won 3 |
| » Starters: Bob Cain vs Bob Feller | First | -- |
| Friday, April 27 |
| » Major-league debuts: Dick Cole (Cardinals) |
| Saturday, April 28 |
| » Defeated Browns (2-8), 12-4 | Sportsman's Park III (1-0) | 7-1 | Won 4 |
| » Starters: Bob Lemon vs Lou Sleater | First | -- |
| Sunday, April 29 |
| » Lost to Browns (3-8), 6-3 | Sportsman's Park III (1-1) | 7-2 | |
| » Starters: Early Wynn vs Ned Garver | First | -- |
| » Lost to Browns (4-8), 13-11 | Sportsman's Park III (1-2) | 7-3 | Lost 2 |
| » Starters: Mike Garcia vs Al Widmar | First | -- |
| Monday, April 30 |
| » Major-league debuts: Earl Mossor (Dodgers) |
| Tuesday, May 1 |
| » Defeated Red Sox (7-5), 7-1 | Cleveland Stadium (5-1) | 8-3 | |
| » Starters: Bill Wight vs Bob Feller | First | -- |
| Wednesday, May 2 |
| » Defeated Red Sox (7-6), 4-3 | Cleveland Stadium (6-1) | 9-3 | Won 2 |
| » Starters: Mel Parnell vs Bob Lemon | First | -- |
| Friday, May 4 |
| » Lost to Athletics (3-13), 3-1 | Cleveland Stadium (6-2) | 9-4 | |
| » Starters: Alex Kellner vs Early Wynn | Third | 1½ out |
| Saturday, May 5 |
| » Defeated Athletics (3-14), 3-2 | Cleveland Stadium (7-2) | 10-4 | |
| » Starters: Dick Fowler vs Mike Garcia | Second | 1½ out |
| Sunday, May 6 |
| » Lost to Senators (11-5), 8-1 | Cleveland Stadium (7-3) | 10-5 | |
| » Starters: Julio Moreno vs Lou Brissie | Second | 2 out |
| » Defeated Senators (11-6), 4-2 | Cleveland Stadium (8-3) | 11-5 | |
| » Starters: Bob Ross vs Bob Chakales | Second | 2 out |
| » Major-league debuts: Willie Miranda (Senators) |
| Monday, May 7 |
| » Lost to Senators (12-6), 11-10 | Cleveland Stadium (8-4) | 11-6 | |
| » Starters: Sandy Consuegra vs Johnny Vander Meer | Third | 2 out |
| Wednesday, May 9 |
| » Lost to Yankees (15-6), 9-2 | Cleveland Stadium (8-5) | 11-7 | Lost 2 |
| » Starters: Ed Lopat vs Bob Lemon | Third | 2½ out |
| Friday, May 11 |
| » Lost to White Sox (11-8), 12-1 | Comiskey Park I (0-1) | 11-8 | Lost 3 |
| » Starters: Early Wynn vs Joe Dobson | Third | 3 out |
| Saturday, May 12 |
| » Lost to White Sox (12-8), 3-2 | Comiskey Park I (0-2) | 11-9 | Lost 4 |
| » Starters: Mike Garcia vs Billy Pierce | Fifth | 4 out |
| Sunday, May 13 |
| » Defeated White Sox (12-9), 11-2 | Comiskey Park I (1-2) | 12-9 | |
| » Starters: Bob Feller vs Ken Holcombe | Third | 2½ out |
| » Tied White Sox, 4-4 | Comiskey Park I (1-2) | 12-9 | |
| » Starters: Bob Chakales vs Bob Cain | Third | 2½ out |
| Monday, May 14 |
| » Lost to Yankees (17-8), 11-4 | Yankee Stadium (0-1) | 12-10 | |
| » Starters: Lou Brissie vs Ed Lopat | Fourth | 3½ out |
| Wednesday, May 16 |
| » Lost to Yankees (18-8), 11-3 | Yankee Stadium (0-2) | 12-11 | Lost 2 |
| » Starters: Bob Lemon vs Vic Raschi | Fourth | 4½ out |
| Thursday, May 17 |
| » Lost to Yankees (19-8), 1-0 | Yankee Stadium (0-3) | 12-12 | Lost 3 |
| » Starters: Early Wynn vs Allie Reynolds | Fifth | 5½ out |
| Friday, May 18 |
| » Lost to Red Sox (13-12), 2-1 | Fenway Park (0-1) | 12-13 | Lost 4 |
| » Starters: Mike Garcia vs Mickey McDermott | Sixth | 5½ out |
| Saturday, May 19 |
| » Lost to Red Sox (14-12), 9-4 | Fenway Park (0-2) | 12-14 | Lost 5 |
| » Starters: Bob Feller vs Mel Parnell | Sixth | 6 out |
| Sunday, May 20 |
| » Lost to Athletics (9-20), 2-1 | Shibe Park (0-1) | 12-15 | Lost 6 |
| » Starters: Bob Lemon vs Dick Fowler | Sixth | 6½ out |
| » Defeated Athletics (9-21), 5-3 | Shibe Park (1-1) | 13-15 | |
| » Starters: Bob Chakales vs Morrie Martin | Sixth | 6½ out |
| Tuesday, May 22 |
| » Defeated Athletics (9-22), 6-2 | Shibe Park (2-1) | 14-15 | Won 2 |
| » Starters: Early Wynn vs Bobby Shantz | Sixth | 7 out |
| Thursday, May 24 |
| » Defeated Senators (15-15), 16-0 | Griffith Stadium (1-0) | 15-15 | Won 3 |
| » Starters: Bob Feller vs Sid Hudson | Fifth | 7 out |
| Friday, May 25 |
| » Lost to White Sox (20-9), 6-4 | Cleveland Stadium (8-6) | 15-16 | |
| » Starters: Billy Pierce vs Bob Lemon | Fifth | 8 out |
| Saturday, May 26 |
| » Lost to White Sox (21-9), 6-0 | Cleveland Stadium (8-7) | 15-17 | Lost 2 |
| » Starters: Ken Holcombe vs Mike Garcia | Fifth | 9 out |
| Sunday, May 27 |
| » Lost to White Sox (22-9), 5-2 | Cleveland Stadium (8-8) | 15-18 | Lost 3 |
| » Starters: Joe Dobson vs Early Wynn | Fifth | 10 out |
| » Lost to White Sox (23-9), 6-4 | Cleveland Stadium (8-9) | 15-19 | Lost 4 |
| » Starters: Howie Judson vs Steve Gromek | Fifth | 10 out |
| Monday, May 28 |
| » Defeated Tigers (17-17), 9-0 | Tiger Stadium (3-0) | 16-19 | |
| » Starters: Bob Feller vs Ted Gray | Fifth | 9 out |
| Tuesday, May 29 |
| » Defeated Tigers (17-18), 2-1 | Tiger Stadium (4-0) | 17-19 | Won 2 |
| » Starters: Bob Lemon vs Bob Cain | Fifth | 8½ out |
| Wednesday, May 30 |
| » Defeated Tigers (17-19), 3-1 | Cleveland Stadium (9-9) | 18-19 | Won 3 |
| » Starters: Dizzy Trout vs Bob Chakales | Fourth | 8½ out |
| » Defeated Tigers (17-20), 4-1 | Cleveland Stadium (10-9) | 19-19 | Won 4 |
| » Starters: Hal Newhouser vs Mike Garcia | Fourth | 8½ out |
| Friday, June 1 |
| » Defeated Senators (16-21), 2-1 | Cleveland Stadium (11-9) | 20-19 | Won 5 |
| » Starters: Julio Moreno vs Early Wynn | Fourth | 8 out |
| Saturday, June 2 |
| » Defeated Senators (16-22), 12-4 | Cleveland Stadium (12-9) | 21-19 | Won 6 |
| » Starters: Sandy Consuegra vs Lou Brissie | Fourth | 7 out |
| Sunday, June 3 |
| » Defeated Yankees (27-14), 8-3 | Cleveland Stadium (13-9) | 22-19 | Won 7 |
| » Starters: Vic Raschi vs Bob Feller | Fourth | 6 out |
| » Defeated Yankees (27-15), 4-1 | Cleveland Stadium (14-9) | 23-19 | Won 8 |
| » Starters: Spec Shea vs Bob Lemon | Fourth | 6 out |
| Monday, June 4 |
| » Defeated Yankees (27-16), 8-2 | Cleveland Stadium (15-9) | 24-19 | Won 9 |
| » Starters: Ed Lopat vs Mike Garcia | Fourth | 6½ out |
| Tuesday, June 5 |
| » Lost to Yankees (28-16), 8-2 | Cleveland Stadium (15-10) | 24-20 | |
| » Starters: Allie Reynolds vs Early Wynn | Fourth | 7½ out |
| Wednesday, June 6 |
| » Lost to Athletics (15-29), 4-3 | Cleveland Stadium (15-11) | 24-21 | Lost 2 |
| » Starters: Alex Kellner vs Bob Chakales | Fourth | 8½ out |
| Thursday, June 7 |
| » Defeated Athletics (15-30), 6-3 | Cleveland Stadium (16-11) | 25-21 | |
| » Starters: Bob Hooper vs Lou Brissie | Fourth | 8½ out |
| Friday, June 8 |
| » Defeated Red Sox (27-20), 7-1 | Cleveland Stadium (17-11) | 26-21 | Won 2 |
| » Starters: Mickey McDermott vs Bob Feller | Fourth | 7½ out |
| Saturday, June 9 |
| » Defeated Red Sox (27-21), 5-1 | Cleveland Stadium (18-11) | 27-21 | Won 3 |
| » Starters: Mel Parnell vs Bob Lemon | Third | 6½ out |
| Sunday, June 10 |
| » Lost to Red Sox (28-21), 9-6 | Cleveland Stadium (18-12) | 27-22 | |
| » Starters: Bill Wight vs Early Wynn | Fourth | 7½ out |
| » Lost to Red Sox (29-21), 8-2 | Cleveland Stadium (18-13) | 27-23 | Lost 2 |
| » Starters: Ray Scarborough vs Mike Garcia | Fourth | 7½ out |
| Tuesday, June 12 |
| » Defeated Athletics (15-34), 8-6 | Shibe Park (3-1) | 28-23 | |
| » Starters: Bob Feller vs Alex Kellner | Fourth | 7½ out |
| Thursday, June 14 |
| » Defeated Athletics (15-35), 3-1 | Shibe Park (4-1) | 29-23 | Won 2 |
| » Starters: Bob Lemon vs Sam Zoldak | Fourth | 8 out |
| Friday, June 15 |
| » Lost to Senators (19-32), 4-2 | Griffith Stadium (1-1) | 29-24 | |
| » Starters: Early Wynn vs Don Johnson | Fourth | 7½ out |
| Saturday, June 16 |
| » Lost to Senators (20-32), 4-3 | Griffith Stadium (1-2) | 29-25 | Lost 2 |
| » Starters: Mike Garcia vs Julio Moreno | Fourth | 7½ out |
| Sunday, June 17 |
| » Lost to Senators (21-32), 5-1 | Griffith Stadium (1-3) | 29-26 | Lost 3 |
| » Starters: Bob Chakales vs Fred Sanford | Fourth | 9 out |
| Monday, June 18 |
| » Defeated Red Sox (33-23), 9-7 | Fenway Park (1-2) | 30-26 | |
| » Starters: Bob Feller vs Harry Taylor | Fourth | 8½ out |
| Tuesday, June 19 |
| » Lost to Red Sox (34-23), 9-2 | Fenway Park (1-3) | 30-27 | |
| » Starters: Bob Lemon vs Chuck Stobbs | Fourth | 9 out |
| Wednesday, June 20 |
| » Defeated Red Sox (34-24), 14-8 | Fenway Park (2-3) | 31-27 | |
| » Starters: Early Wynn vs Bill Wight | Fourth | 8 out |
| Thursday, June 21 |
| » Defeated Red Sox (34-25), 8-4 | Fenway Park (3-3) | 32-27 | Won 2 |
| » Starters: Mike Garcia vs Mickey McDermott | Fourth | 8 out |
| Friday, June 22 |
| » Lost to Yankees (37-22), 6-0 | Yankee Stadium (0-4) | 32-28 | |
| » Starters: Bob Feller vs Allie Reynolds | Fourth | 8 out |
| Saturday, June 23 |
| » Lost to Yankees (38-22), 7-6 | Yankee Stadium (0-5) | 32-29 | Lost 2 |
| » Starters: Bob Lemon vs Stubby Overmire | Fourth | 8 out |
| Sunday, June 24 |
| » Lost to Yankees (39-22), 5-3 | Yankee Stadium (0-6) | 32-30 | Lost 3 |
| » Starters: Early Wynn vs Vic Raschi | Fourth | 8½ out |
| Tuesday, June 26 |
| » Defeated Browns (19-44), 6-4 | Cleveland Stadium (19-13) | 33-30 | |
| » Starters: Duane Pillette vs Bob Feller | Fourth | 8½ out |
| Wednesday, June 27 |
| » Defeated Browns (19-45), 8-1 | Cleveland Stadium (20-13) | 34-30 | Won 2 |
| » Starters: Al Widmar vs Mike Garcia | Fourth | 7½ out |
| Friday, June 29 |
| » Defeated Tigers (31-31), 4-1 | Cleveland Stadium (21-13) | 35-30 | Won 3 |
| » Starters: Dizzy Trout vs Bob Lemon | Fourth | 7½ out |
| Saturday, June 30 |
| » Defeated Tigers (31-32), 3-1 | Cleveland Stadium (22-13) | 36-30 | Won 4 |
| » Starters: Fred Hutchinson vs Early Wynn | Fourth | 6½ out |
| Sunday, July 1 |
| » Defeated Tigers (31-33), 2-1 | Cleveland Stadium (23-13) | 37-30 | Won 5 |
| » Starters: Bob Cain vs Bob Feller | Fourth | 5½ out |
| » Defeated Tigers (31-34), 2-0 | Cleveland Stadium (24-13) | 38-30 | Won 6 |
| » Starters: Ted Gray vs Bob Chakales | Fourth | 5½ out |
| Monday, July 2 |
| » Defeated White Sox (44-26), 3-2 | Comiskey Park I (2-2) | 39-30 | Won 7 |
| » Starters: Mike Garcia vs Saul Rogovin | Fourth | 5½ out |
| Tuesday, July 3 |
| » Lost to White Sox (45-26), 4-1 | Comiskey Park I (2-3) | 39-31 | |
| » Starters: Bob Lemon vs Billy Pierce | Fourth | 6 out |
| Wednesday, July 4 |
| » Defeated Browns (21-48), 6-5 | Sportsman's Park III (2-2) | 40-31 | |
| » Starters: Early Wynn vs Al Widmar | Fourth | 4½ out |
| » Defeated Browns (21-49), 4-3 | Sportsman's Park III (3-2) | 41-31 | Won 2 |
| » Starters: Steve Gromek vs Tommy Byrne | Fourth | 4½ out |
| Friday, July 6 |
| » Defeated Tigers (33-36), 7-4 | Tiger Stadium (5-0) | 42-31 | Won 3 |
| » Starters: Bob Feller vs Ted Gray | Fourth | 3½ out |
| Former Indian Ted Easterly dies in Clearlake Highlands, CA at the age of 67. |
| Saturday, July 7 |
| » Lost to Tigers (34-36), 13-3 | Tiger Stadium (5-1) | 42-32 | |
| » Starters: Bob Lemon vs Bob Cain | Fourth | 4½ out |
| Sunday, July 8 |
| » Defeated Tigers (34-37), 8-3 | Tiger Stadium (6-1) | 43-32 | |
| » Starters: Early Wynn vs Gene Bearden | Fourth | 4 out |
| » Defeated Tigers (34-38), 10-2 | Tiger Stadium (7-1) | 44-32 | Won 2 |
| » Starters: Mike Garcia vs Hal White | Fourth | 4 out |
| Future Indian Alan Ashby is born in Long Beach, CA. |
| Thursday, July 12 |
| » Lost to Yankees (46-29), 1-0 | Cleveland Stadium (24-14) | 44-33 | |
| » Starters: Allie Reynolds vs Bob Feller | Fourth | 4½ out |
| Friday, July 13 |
| » Defeated Yankees (46-30), 11-8 | Cleveland Stadium (25-14) | 45-33 | |
| » Starters: Vic Raschi vs Bob Lemon | Fourth | 3½ out |
| Saturday, July 14 |
| » Defeated Yankees (46-31), 8-0 | Cleveland Stadium (26-14) | 46-33 | Won 2 |
| » Starters: Ed Lopat vs Early Wynn | Fourth | 3½ out |
| Sunday, July 15 |
| » Lost to Senators (34-45), 7-4 | Cleveland Stadium (26-15) | 46-34 | |
| » Starters: Connie Marrero vs Bob Chakales | Fourth | 3½ out |
| » Defeated Senators (34-46), 7-2 | Cleveland Stadium (27-15) | 47-34 | |
| » Starters: Sid Hudson vs Mike Garcia | Fourth | 3½ out |
| Monday, July 16 |
| » Defeated Senators (34-47), 8-2 | Cleveland Stadium (28-15) | 48-34 | Won 2 |
| » Starters: Julio Moreno vs Steve Gromek | Fourth | 2½ out |
| Tuesday, July 17 |
| » Defeated Red Sox (51-33), 8-6 | Cleveland Stadium (29-15) | 49-34 | Won 3 |
| » Starters: Mel Parnell vs Bob Feller | Fourth | 1½ out |
| Wednesday, July 18 |
| » Lost to Red Sox (52-33), 4-3 | Cleveland Stadium (29-16) | 49-35 | |
| » Starters: Leo Kiely vs Bob Lemon | Fourth | 2½ out |
| Thursday, July 19 |
| » Defeated Red Sox (52-34), 5-4 | Cleveland Stadium (30-16) | 50-35 | |
| » Starters: Mickey McDermott vs Early Wynn | Fourth | 1½ out |
| Friday, July 20 |
| » Defeated Athletics (36-53), 1-0 | Cleveland Stadium (31-16) | 51-35 | Won 2 |
| » Starters: Sam Zoldak vs Mike Garcia | Fourth | ½ out |
| Saturday, July 21 |
| » Defeated Athletics (36-54), 5-3 | Cleveland Stadium (32-16) | 52-35 | Won 3 |
| » Starters: Bobby Shantz vs Bob Feller | Third | ½ out |
| Sunday, July 22 |
| » Defeated Athletics (36-55), 6-4 | Cleveland Stadium (33-16) | 53-35 | Won 4 |
| » Starters: Dick Fowler vs Bob Lemon | Second | 1 out |
| » Defeated Athletics (36-56), 3-1 | Cleveland Stadium (34-16) | 54-35 | Won 5 |
| » Starters: Alex Kellner vs Steve Gromek | Second | 1 out |
| Tuesday, July 24 |
| » Lost to Yankees (54-34), 3-2 | Yankee Stadium (0-7) | 54-36 | |
| » Starters: Early Wynn vs Vic Raschi | Third | 1 out |
| Wednesday, July 25 |
| » Lost to Yankees (55-34), 2-1 | Yankee Stadium (0-8) | 54-37 | Lost 2 |
| » Starters: Mike Garcia vs Ed Lopat | Third | 2 out |
| Thursday, July 26 |
| » Defeated Yankees (55-35), 9-4 | Yankee Stadium (1-8) | 55-37 | |
| » Starters: Bob Feller vs Allie Reynolds | Third | 1 out |
| Friday, July 27 |
| » Defeated Red Sox (56-37), 3-2 | Fenway Park (4-3) | 56-37 | Won 2 |
| » Starters: Bob Lemon vs Ray Scarborough | Second | 1 out |
| Saturday, July 28 |
| » Lost to Red Sox (57-37), 8-4 | Fenway Park (4-4) | 56-38 | |
| » Starters: Early Wynn vs Mickey McDermott | Third | 1½ out |
| Sunday, July 29 |
| » Defeated Red Sox (57-38), 5-4 | Fenway Park (5-4) | 57-38 | |
| » Starters: Mike Garcia vs Leo Kiely | Second | 2 out |
| Tuesday, July 31 |
| » Defeated Senators (43-53), 5-3 | Griffith Stadium (2-3) | 58-38 | Won 2 |
| » Starters: Bob Feller vs Don Johnson | Second | 2 out |
| Wednesday, August 1 |
| » Defeated Senators (43-54), 8-6 | Griffith Stadium (3-3) | 59-38 | Won 3 |
| » Starters: Bob Lemon vs Dick Starr | Second | 2 out |
| » Lost to Senators (44-54), 4-3 | Griffith Stadium (3-4) | 59-39 | |
| » Starters: Early Wynn vs Julio Moreno | Second | 2 out |
| Thursday, August 2 |
| » Defeated Senators (44-55), 5-2 | Griffith Stadium (4-4) | 60-39 | |
| » Starters: Steve Gromek vs Bob Porterfield | Second | 1 out |
| Friday, August 3 |
| » Defeated Athletics (39-63), 3-2 | Shibe Park (5-1) | 61-39 | Won 2 |
| » Starters: Mike Garcia vs Sam Zoldak | Second | ½ out |
| Saturday, August 4 |
| » Defeated Athletics (39-64), 4-2 | Shibe Park (6-1) | 62-39 | Won 3 |
| » Starters: Bob Feller vs Dick Fowler | Second | ½ out |
| Sunday, August 5 |
| » Defeated Athletics (39-65), 6-3 | Shibe Park (7-1) | 63-39 | Won 4 |
| » Starters: Bob Lemon vs Alex Kellner | Second | ½ out |
| » Defeated Athletics (39-66), 6-3 | Shibe Park (8-1) | 64-39 | Won 5 |
| » Starters: Early Wynn vs Morrie Martin | Second | ½ out |
| Tuesday, August 7 |
| » Defeated Browns (32-72), 5-1 | Cleveland Stadium (35-16) | 65-39 | Won 6 |
| » Starters: Jim McDonald vs Mike Garcia | Second | ½ out |
| Wednesday, August 8 |
| » Defeated Browns (32-73), 2-1 | Cleveland Stadium (36-16) | 66-39 | Won 7 |
| » Starters: Tommy Byrne vs Bob Feller | First | -- |
| Friday, August 10 |
| » Defeated White Sox (60-48), 6-4 | Cleveland Stadium (37-16) | 67-39 | Won 8 |
| » Starters: Ken Holcombe vs Bob Lemon | First | -- |
| Saturday, August 11 |
| » Defeated White Sox (60-49), 2-1 | Cleveland Stadium (38-16) | 68-39 | Won 9 |
| » Starters: Joe Dobson vs Early Wynn | First | -- |
| Sunday, August 12 |
| » Defeated White Sox (60-50), 7-1 | Cleveland Stadium (39-16) | 69-39 | Won 10 |
| » Starters: Billy Pierce vs Mike Garcia | First | -- |
| Monday, August 13 |
| » Defeated Tigers (51-57), 2-1 | Cleveland Stadium (40-16) | 70-39 | Won 11 |
| » Starters: Marlin Stuart vs Bob Feller | First | -- |
| Tuesday, August 14 |
| » Defeated Tigers (51-58), 6-5 | Cleveland Stadium (41-16) | 71-39 | Won 12 |
| » Starters: Fred Hutchinson vs Bob Lemon | First | -- |
| Wednesday, August 15 |
| » Defeated Browns (34-76), 9-4 | Sportsman's Park III (4-2) | 72-39 | Won 13 |
| » Starters: Early Wynn vs Ned Garver | First | -- |
| Thursday, August 16 |
| » Lost to Browns (35-76), 4-0 | Sportsman's Park III (4-3) | 72-40 | |
| » Starters: Mike Garcia vs Tommy Byrne | First | -- |
| Friday, August 17 |
| » Lost to White Sox (62-51), 7-1 | Comiskey Park I (2-4) | 72-41 | Lost 2 |
| » Starters: Bob Feller vs Billy Pierce | First | -- |
| » Lost to White Sox (63-51), 8-3 | Comiskey Park I (2-5) | 72-42 | Lost 3 |
| » Starters: Bob Chakales vs Randy Gumpert | First | -- |
| Saturday, August 18 |
| » Defeated White Sox (63-52), 7-0 | Comiskey Park I (3-5) | 73-42 | |
| » Starters: Bob Lemon vs Ken Holcombe | First | -- |
| Sunday, August 19 |
| » Defeated White Sox (63-53), 4-0 | Comiskey Park I (4-5) | 74-42 | Won 2 |
| » Starters: Early Wynn vs Howie Judson | First | -- |
| » Lost to White Sox (64-53), 7-6 | Comiskey Park I (4-6) | 74-43 | |
| » Starters: Steve Gromek vs Lou Kretlow | First | -- |
| Monday, August 20 |
| » Defeated Senators (47-69), 5-3 | Cleveland Stadium (42-16) | 75-43 | |
| » Starters: Dick Starr vs Mike Garcia | First | -- |
| Tuesday, August 21 |
| » Defeated Senators (47-70), 6-0 | Cleveland Stadium (43-16) | 76-43 | Won 2 |
| » Starters: Don Johnson vs Bob Feller | First | -- |
| Wednesday, August 22 |
| » Defeated Senators (47-71), 6-5 | Cleveland Stadium (44-16) | 77-43 | Won 3 |
| » Starters: Julio Moreno vs Bob Chakales | First | -- |
| Thursday, August 23 |
| » Defeated Yankees (75-46), 2-1 | Cleveland Stadium (45-16) | 78-43 | Won 4 |
| » Starters: Vic Raschi vs Bob Lemon | First | -- |
| Friday, August 24 |
| » Lost to Yankees (76-46), 2-0 | Cleveland Stadium (45-17) | 78-44 | |
| » Starters: Stubby Overmire vs Early Wynn | First | -- |
| Saturday, August 25 |
| » Lost to Yankees (77-46), 7-3 | Cleveland Stadium (45-18) | 78-45 | Lost 2 |
| » Starters: Ed Lopat vs Mike Garcia | First | -- |
| Sunday, August 26 |
| » Lost to Red Sox (73-49), 5-0 | Cleveland Stadium (45-19) | 78-46 | Lost 3 |
| » Starters: Bill Wight vs Bob Feller | First | -- |
| » Defeated Red Sox (73-50), 2-1 | Cleveland Stadium (46-19) | 79-46 | |
| » Starters: Leo Kiely vs Bob Lemon | First | -- |
| Monday, August 27 |
| Future Indian Buddy Bell is born in Pittsburgh, PA. |
| Tuesday, August 28 |
| » Defeated Athletics (51-77), 1-0 | Cleveland Stadium (47-19) | 80-46 | Won 2 |
| » Starters: Sam Zoldak vs Early Wynn | First | -- |
| Wednesday, August 29 |
| » Lost to Athletics (52-77), 3-0 | Cleveland Stadium (47-20) | 80-47 | |
| » Starters: Alex Kellner vs Mike Garcia | First | -- |
| Thursday, August 30 |
| » Lost to Athletics (53-77), 6-2 | Cleveland Stadium (47-21) | 80-48 | Lost 2 |
| » Starters: Morrie Martin vs Bob Feller | Second | ½ out |
| Friday, August 31 |
| » Lost to Browns (39-86), 6-3 | Cleveland Stadium (47-22) | 80-49 | Lost 3 |
| » Starters: Jim McDonald vs Bob Lemon | Second | 1 out |
| Saturday, September 1 |
| » Defeated Browns (39-87), 2-1 | Cleveland Stadium (48-22) | 81-49 | |
| » Starters: Tommy Byrne vs Early Wynn | Second | 1 out |
| Sunday, September 2 |
| » Defeated Browns (39-88), 5-1 | Cleveland Stadium (49-22) | 82-49 | Won 2 |
| » Starters: Ned Garver vs Mike Garcia | Second | 1½ out |
| » Major-league debuts: Bud Thomas (Browns) |
| Monday, September 3 |
| » Defeated White Sox (71-60), 5-3 | Cleveland Stadium (50-22) | 83-49 | Won 3 |
| » Starters: Lou Kretlow vs Bob Feller | First | -- |
| » Defeated White Sox (71-61), 6-1 | Cleveland Stadium (51-22) | 84-49 | Won 4 |
| » Starters: Harry Dorish vs Steve Gromek | First | -- |
| » Major-league debuts: Ross Grimsley (White Sox) |
| Future Indian Alan Bannister is born in Montebello, CA. |
| Tuesday, September 4 |
| » Lost to White Sox (72-61), 3-1 | Cleveland Stadium (51-23) | 84-50 | |
| » Starters: Saul Rogovin vs Bob Lemon | Second | 2 out |
| Wednesday, September 5 |
| » Defeated Tigers (61-72), 5-2 | Cleveland Stadium (52-23) | 85-50 | |
| » Starters: Marlin Stuart vs Early Wynn | First | -- |
| Friday, September 7 |
| » Lost to Browns (41-90), 4-2 | Sportsman's Park III (4-4) | 85-51 | |
| » Starters: Mike Garcia vs Ned Garver | Second | 2½ out |
| » Defeated Browns (41-91), 7-0 | Sportsman's Park III (5-4) | 86-51 | |
| » Starters: Bob Feller vs Tommy Byrne | Second | 2½ out |
| Saturday, September 8 |
| » Defeated Browns (41-92), 6-3 | Sportsman's Park III (6-4) | 87-51 | Won 2 |
| » Starters: Bob Lemon vs Fred Sanford | Second | 2½ out |
| Sunday, September 9 |
| » Defeated Browns (41-93), 4-3 | Sportsman's Park III (7-4) | 88-51 | Won 3 |
| » Starters: Early Wynn vs Duane Pillette | Second | 2 out |
| Monday, September 10 |
| Former Indian Hank DeBerry dies in Savannah, TN at the age of 57. |
| Tuesday, September 11 |
| » Defeated Athletics (59-81), 6-5 | Shibe Park (9-1) | 89-51 | Won 4 |
| » Starters: Mike Garcia vs Sam Zoldak | First | -- |
| » Lost to Athletics (60-81), 9-5 | Shibe Park (9-2) | 89-52 | |
| » Starters: Bob Feller vs Alex Kellner | First | -- |
| Thursday, September 13 |
| » Lost to Senators (55-82), 1-0 | Griffith Stadium (4-5) | 89-53 | Lost 2 |
| » Starters: Bob Lemon vs Bob Porterfield | First | -- |
| Saturday, September 15 |
| » Defeated Senators (55-83), 4-2 | Griffith Stadium (5-5) | 90-53 | |
| » Starters: Early Wynn vs Don Johnson | First | -- |
| » Lost to Senators (56-83), 7-6 | Griffith Stadium (5-6) | 90-54 | |
| » Starters: Steve Gromek vs Julio Moreno | First | -- |
| Sunday, September 16 |
| » Lost to Yankees (88-53), 5-1 | Yankee Stadium (1-9) | 90-55 | Lost 2 |
| » Starters: Bob Feller vs Allie Reynolds | Second | 2 out |
| Monday, September 17 |
| » Lost to Yankees (89-53), 2-1 | Yankee Stadium (1-10) | 90-56 | Lost 3 |
| » Starters: Bob Lemon vs Ed Lopat | Second | 2 out |
| Tuesday, September 18 |
| » Defeated Red Sox (86-56), 6-4 | Fenway Park (6-4) | 91-56 | |
| » Starters: Mike Garcia vs Bill Wight | Second | 2 out |
| Wednesday, September 19 |
| » Defeated Red Sox (86-57), 15-2 | Fenway Park (7-4) | 92-56 | Won 2 |
| » Starters: Early Wynn vs Mickey McDermott | Second | 2 out |
| Friday, September 21 |
| » Lost to Tigers (69-78), 7-6 | Tiger Stadium (7-2) | 92-57 | |
| » Starters: Bob Feller vs Ted Gray | Second | 1½ out |
| Saturday, September 22 |
| » Lost to Tigers (70-78), 9-4 | Tiger Stadium (7-3) | 92-58 | Lost 2 |
| » Starters: Bob Lemon vs Bob Cain | Second | 1½ out |
| » Major-league debuts: Sam Jones (Indians) |
| Sunday, September 23 |
| » Lost to Tigers (71-78), 9-1 | Tiger Stadium (7-4) | 92-59 | Lost 3 |
| » Starters: Mike Garcia vs Virgil Trucks | Second | 2½ out |
| » Major-league debuts: Hal Naragon (Indians) |
| Tuesday, September 25 |
| » Lost to White Sox (78-72), 4-2 | Comiskey Park I (4-7) | 92-60 | Lost 4 |
| » Starters: Early Wynn vs Billy Pierce | Second | 3 out |
| Thursday, September 27 |
| » Major-league debuts: Jim Dyck (Browns) |
| Saturday, September 29 |
| » Defeated Tigers (72-81), 7-6 | Cleveland Stadium (53-23) | 93-60 | |
| » Starters: Bob Cain vs Dick Rozek | Second | 4 out |
| Sunday, September 30 |
| » Lost to Tigers (73-81), 2-1 | Cleveland Stadium (53-24) | 93-61 | |
| » Starters: Virgil Trucks vs Sam Jones | Second | 5 out |
| Wednesday, October 3 |
| Future Indian Dave Winfield is born in St. Paul, MN. |
| Thursday, October 4 |
| Future Indian Horace Speed is born in Los Angeles, CA. |
| Sunday, October 21 |
| Future Indian Ron Pruitt is born in Flint, MI. |
| Wednesday, October 31 |
| Future Indian Dave Freisleben is born in Coraopolis, PA. |
| Monday, November 5 |
| Former Indian George |
