| Saturday, January 6 |
| Former Cardinal Harry Camnitz dies in Louisville, KY at the age of 67. |
| Saturday, February 3 |
| Future Cardinal Mike Wallace is born in Gastonia, NC. |
| Sunday, February 4 |
| Future Cardinal Stan Papi is born in Fresno, CA. |
| Wednesday, February 7 |
| Future Cardinal Benny Ayala is born in Yauco, P.R. |
| Friday, February 9 |
| Future Cardinal Eddie Solomon is born in Perry, GA. |
| Thursday, February 15 |
| Future Cardinal Tommy Cruz is born in Arroyo, P.R. |
| Sunday, February 25 |
| Future Cardinal Cesar Cedeno is born in Santo Domingo, D.R. |
| Friday, April 13 |
| Former Cardinal Wish Egan dies in Detroit, MI at the age of 70. |
| Tuesday, April 17 |
| » Lost to Pirates (2-0), 5-4 | Forbes Field (0-1) | 0-1 | |
| » Starters: Tom Poholsky vs Murry Dickson | Third | 1½ out |
| Friday, April 20 |
| » Defeated Cubs (2-1), 5-1 | Sportsman's Park III (1-0) | 1-1 | |
| » Starters: Johnny Schmitz vs Gerry Staley | Fourth | 1 out |
| » Major-league debuts: Bob Schultz (Cubs) |
| Saturday, April 21 |
| » Major-league debuts: Leo Cristante (Phillies) George Estock (Braves) |
| Sunday, April 22 |
| » Lost to Cubs (3-1), 10-5 | Sportsman's Park III (1-1) | 1-2 | |
| » Starters: Bob Rush vs Cloyd Boyer | Fifth | 2 out |
| Monday, April 23 |
| » Defeated Reds (1-5), 2-1 | Sportsman's Park III (2-1) | 2-2 | |
| » Starters: Ken Raffensberger vs Harry Brecheen | Fourth | 2 out |
| Tuesday, April 24 |
| » Defeated Reds (1-6), 3-1 | Sportsman's Park III (3-1) | 3-2 | Won 2 |
| » Starters: Willie Ramsdell vs Max Lanier | Third | 1 out |
| Wednesday, April 25 |
| » Defeated Pirates (4-3), 4-0 | Sportsman's Park III (4-1) | 4-2 | Won 3 |
| » Starters: Cliff Chambers vs Tom Poholsky | First | -- |
| Friday, April 27 |
| » Defeated Cubs (4-4), 3-0 | Wrigley Field (1-0) | 5-2 | Won 4 |
| » Starters: Gerry Staley vs Bob Schultz | First | -- |
| » Major-league debuts: Dick Cole (Cardinals) |
| Saturday, April 28 |
| » Lost to Cubs (5-4), 8-2 | Wrigley Field (1-1) | 5-3 | |
| » Starters: Cloyd Boyer vs Bob Rush | Third | 2½ out |
| Sunday, April 29 |
| » Defeated Cubs (5-5), 6-3 | Wrigley Field (2-1) | 6-3 | |
| » Starters: Harry Brecheen vs Frank Hiller | Third | 3 out |
| Monday, April 30 |
| » Major-league debuts: Earl Mossor (Dodgers) |
| Tuesday, May 1 |
| » Defeated Braves (10-6), 5-2 | Braves Field (1-0) | 7-3 | Won 2 |
| » Starters: Tom Poholsky vs Johnny Sain | First | -- |
| Wednesday, May 2 |
| » Lost to Braves (11-6), 5-0 | Braves Field (1-1) | 7-4 | |
| » Starters: Gerry Staley vs Warren Spahn | Second | 3 out |
| Thursday, May 3 |
| » Defeated Phillies (8-8), 8-4 | Shibe Park (1-0) | 8-4 | |
| » Starters: Max Lanier vs Jocko Thompson | First | -- |
| Friday, May 4 |
| » Lost to Phillies (9-8), 6-4 | Shibe Park (1-1) | 8-5 | |
| » Starters: Howie Pollet vs Russ Meyer | Second | 3 out |
| Saturday, May 5 |
| » Defeated Phillies (9-9), 4-3 | Shibe Park (2-1) | 9-5 | |
| » Starters: Red Munger vs Ken Johnson | First | -- |
| Sunday, May 6 |
| » Defeated Dodgers (10-9), 11-7 | Ebbets Field (1-0) | 10-5 | Won 2 |
| » Starters: Tom Poholsky vs Don Newcombe | First | -- |
| Monday, May 7 |
| » Lost to Dodgers (11-9), 4-3 | Ebbets Field (1-1) | 10-6 | |
| » Starters: Gerry Staley vs Preacher Roe | First | -- |
| Tuesday, May 8 |
| » Lost to Giants (9-14), 6-2 | Polo Grounds V (0-1) | 10-7 | Lost 2 |
| » Starters: Joe Presko vs Larry Jansen | Second | 3 out |
| Wednesday, May 9 |
| » Lost to Giants (10-14), 17-3 | Polo Grounds V (0-2) | 10-8 | Lost 3 |
| » Starters: Max Lanier vs Sal Maglie | Second | 3 out |
| » Major-league debuts: Bill Sarni (Cardinals) |
| Thursday, May 10 |
| » Lost to Giants (11-14), 3-2 | Polo Grounds V (0-3) | 10-9 | Lost 4 |
| » Starters: Tom Poholsky vs Roger Bowman | Fourth | 3 out |
| Saturday, May 12 |
| » Lost to Reds (9-13), 7-2 | Crosley Field (0-1) | 10-10 | Lost 5 |
| » Starters: Gerry Staley vs Ken Raffensberger | Third | 2 out |
| » Defeated Reds (9-14), 8-6 | Crosley Field (1-1) | 11-10 | |
| » Starters: Cloyd Boyer vs Herm Wehmeier | Third | 2 out |
| Sunday, May 13 |
| » Lost to Reds (10-14), 7-2 | Crosley Field (1-2) | 11-11 | |
| » Starters: Max Lanier vs Howie Fox | Fourth | 2½ out |
| » Lost to Reds (11-14), 6-3 | Crosley Field (1-3) | 11-12 | Lost 2 |
| » Starters: Joe Presko vs Willie Ramsdell | Fourth | 2½ out |
| Tuesday, May 15 |
| » Lost to Phillies (13-14), 5-4 | Sportsman's Park III (4-2) | 11-13 | Lost 3 |
| » Starters: Russ Meyer vs Tom Poholsky | Seventh | 3½ out |
| Wednesday, May 16 |
| » Defeated Phillies (13-15), 5-3 | Sportsman's Park III (5-2) | 12-13 | |
| » Starters: Bubba Church vs Gerry Staley | Fifth | 2½ out |
| Thursday, May 17 |
| » Defeated Phillies (13-16), 2-1 | Sportsman's Park III (6-2) | 13-13 | Won 2 |
| » Starters: Robin Roberts vs Joe Presko | Fourth | 1½ out |
| Friday, May 18 |
| » Lost to Dodgers (16-12), 6-3 | Sportsman's Park III (6-3) | 13-14 | |
| » Starters: Preacher Roe vs Cloyd Boyer | Sixth | 2½ out |
| Saturday, May 19 |
| » Defeated Dodgers (16-13), 6-4 | Sportsman's Park III (7-3) | 14-14 | |
| » Starters: Don Newcombe vs Tom Poholsky | Fourth | 1½ out |
| Sunday, May 20 |
| » Defeated Giants (16-18), 8-7 | Sportsman's Park III (8-3) | 15-14 | Won 2 |
| » Starters: Jim Hearn vs Harry Brecheen | Third | 2 out |
| Monday, May 21 |
| » Defeated Giants (16-19), 5-2 | Sportsman's Park III (9-3) | 16-14 | Won 3 |
| » Starters: Larry Jansen vs Gerry Staley | Third | 1½ out |
| Tuesday, May 22 |
| » Lost to Braves (18-16), 7-2 | Sportsman's Park III (9-4) | 16-15 | |
| » Starters: Warren Spahn vs Red Munger | Fourth | 2½ out |
| Wednesday, May 23 |
| » Defeated Braves (18-17), 6-5 | Sportsman's Park III (10-4) | 17-15 | |
| » Starters: Max Surkont vs Howie Pollet | Second | 2½ out |
| Thursday, May 24 |
| » Defeated Reds (15-19), 11-3 | Sportsman's Park III (11-4) | 18-15 | Won 2 |
| » Starters: Ken Raffensberger vs Joe Presko | Second | 2 out |
| Friday, May 25 |
| » Lost to Reds (16-19), 5-1 | Sportsman's Park III (11-5) | 18-16 | |
| » Starters: Ewell Blackwell vs Harry Brecheen | Second | 3 out |
| Saturday, May 26 |
| » Lost to Reds (17-19), 5-2 | Sportsman's Park III (11-6) | 18-17 | Lost 2 |
| » Starters: Howie Fox vs Max Lanier | Fourth | 3 out |
| Sunday, May 27 |
| » Defeated Reds (17-20), 6-1 | Sportsman's Park III (12-6) | 19-17 | |
| » Starters: Willie Ramsdell vs Gerry Staley | Third | 2½ out |
| Monday, May 28 |
| » Defeated Pirates (15-21), 6-5 | Sportsman's Park III (13-6) | 20-17 | Won 2 |
| » Starters: Cliff Chambers vs Tom Poholsky | Second | 2½ out |
| » Major-league debuts: Paul LaPalme (Pirates) |
| Wednesday, May 30 |
| » Defeated Pirates (15-22), 4-3 | Sportsman's Park III (14-6) | 21-17 | Won 3 |
| » Starters: Murry Dickson vs Joe Presko | Second | 1½ out |
| » Defeated Pirates (15-23), 7-3 | Sportsman's Park III (15-6) | 22-17 | Won 4 |
| » Starters: Mel Queen vs Red Munger | Second | 1½ out |
| Friday, June 1 |
| » Lost to Phillies (18-24), 7-3 | Shibe Park (2-2) | 22-18 | |
| » Starters: Gerry Staley vs Jocko Thompson | Second | 2 out |
| Saturday, June 2 |
| » Lost to Phillies (19-24), 5-2 | Shibe Park (2-3) | 22-19 | Lost 2 |
| » Starters: Tom Poholsky vs Ken Heintzelman | Second | 3 out |
| Sunday, June 3 |
| » Lost to Giants (24-21), 1-0 | Polo Grounds V (0-4) | 22-20 | Lost 3 |
| » Starters: Max Lanier vs Dave Koslo | Second | 4 out |
| » Defeated Giants (24-22), 4-3 | Polo Grounds V (1-4) | 23-20 | |
| » Starters: Harry Brecheen vs Roger Bowman | Second | 4 out |
| Monday, June 4 |
| » Defeated Giants (24-23), 7-2 | Polo Grounds V (2-4) | 24-20 | Won 2 |
| » Starters: Joe Presko vs Larry Jansen | Second | 3½ out |
| Tuesday, June 5 |
| » Lost to Dodgers (28-16), 3-2 | Ebbets Field (1-2) | 24-21 | |
| » Starters: Red Munger vs Joe Hatten | Second | 4½ out |
| Wednesday, June 6 |
| » Lost to Dodgers (29-16), 3-2 | Ebbets Field (1-3) | 24-22 | Lost 2 |
| » Starters: Gerry Staley vs Ralph Branca | Second | 5½ out |
| Thursday, June 7 |
| » Lost to Dodgers (30-16), 2-1 | Ebbets Field (1-4) | 24-23 | Lost 3 |
| » Starters: Tom Poholsky vs Preacher Roe | Second | 6½ out |
| Friday, June 8 |
| » Defeated Braves (24-25), 2-1 | Braves Field (2-1) | 25-23 | |
| » Starters: Joe Presko vs Max Surkont | Second | 6 out |
| Saturday, June 9 |
| » Lost to Braves (25-25), 6-1 | Braves Field (2-2) | 25-24 | |
| » Starters: Max Lanier vs Chet Nichols | Fourth | 6 out |
| Sunday, June 10 |
| » Defeated Braves (25-26), 5-4 | Braves Field (3-2) | 26-24 | |
| » Starters: Harry Brecheen vs Warren Spahn | Third | 5½ out |
| Tuesday, June 12 |
| » Lost to Dodgers (32-18), 6-2 | Sportsman's Park III (15-7) | 26-25 | |
| » Starters: Preacher Roe vs Gerry Staley | Third | 6½ out |
| Wednesday, June 13 |
| » Lost to Dodgers (33-18), 7-4 | Sportsman's Park III (15-8) | 26-26 | Lost 2 |
| » Starters: Joe Hatten vs Tom Poholsky | Fourth | 7½ out |
| Thursday, June 14 |
| » Lost to Dodgers (34-18), 2-1 | Sportsman's Park III (15-9) | 26-27 | Lost 3 |
| » Starters: Ralph Branca vs Joe Presko | Third | 8½ out |
| Friday, June 15 |
| » Defeated Phillies (26-28), 10-2 | Sportsman's Park III (16-9) | 27-27 | |
| » Starters: Ken Heintzelman vs Max Lanier | Fourth | 8½ out |
| Saturday, June 16 |
| » Defeated Phillies (26-29), 6-5 | Sportsman's Park III (17-9) | 28-27 | Won 2 |
| » Starters: Jocko Thompson vs Gerry Staley | Third | 7½ out |
| Sunday, June 17 |
| » Defeated Phillies (26-30), 5-4 | Sportsman's Park III (18-9) | 29-27 | Won 3 |
| » Starters: Robin Roberts vs Harry Brecheen | Third | 7½ out |
| Monday, June 18 |
| » Lost to Giants (34-27), 5-4 | Sportsman's Park III (18-10) | 29-28 | |
| » Starters: Dave Koslo vs Joe Presko | Third | 8 out |
| Tuesday, June 19 |
| » Lost to Giants (35-27), 2-1 | Sportsman's Park III (18-11) | 29-29 | Lost 2 |
| » Starters: Larry Jansen vs Cliff Chambers | Third | 9 out |
| Wednesday, June 20 |
| » Defeated Giants (35-28), 4-2 | Sportsman's Park III (19-11) | 30-29 | |
| » Starters: Jim Hearn vs Red Munger | Third | 8 out |
| Thursday, June 21 |
| » Defeated Giants (35-29), 2-0 | Sportsman's Park III (20-11) | 31-29 | Won 2 |
| » Starters: Sheldon Jones vs Gerry Staley | Third | 8 out |
| Friday, June 22 |
| » Lost to Braves (30-31), 8-7 | Sportsman's Park III (20-12) | 31-30 | |
| » Starters: Chet Nichols vs Tom Poholsky | Third | 9 out |
| Future Cardinal Mike Anderson is born in Florence, SC. |
| Sunday, June 24 |
| » Defeated Braves (30-32), 6-5 | Sportsman's Park III (21-12) | 32-30 | |
| » Starters: Warren Spahn vs Cliff Chambers | Third | 8 out |
| Future Cardinal Ken Reitz is born in San Francisco, CA. |
| Tuesday, June 26 |
| » Lost to Cubs (27-32), 7-5 | Sportsman's Park III (21-13) | 32-31 | |
| » Starters: Paul Minner vs Gerry Staley | Third | 8 out |
| Wednesday, June 27 |
| » Defeated Cubs (27-33), 14-2 | Sportsman's Park III (22-13) | 33-31 | |
| » Starters: Bob Schultz vs Joe Presko | Third | 8 out |
| Thursday, June 28 |
| » Lost to Cubs (28-33), 8-0 | Sportsman's Park III (22-14) | 33-32 | |
| » Starters: Frank Hiller vs Gerry Staley | Third | 8 out |
| Friday, June 29 |
| » Tied Cubs, 6-6 | Sportsman's Park III (22-14) | 33-32 | |
| » Starters: Bob Rush vs Tom Poholsky | Third | 7½ out |
| Saturday, June 30 |
| » Defeated Pirates (25-41), 8-4 | Sportsman's Park III (23-14) | 34-32 | |
| » Starters: Murry Dickson vs Cliff Chambers | Third | 7½ out |
| Sunday, July 1 |
| » Defeated Pirates (25-42), 5-4 | Sportsman's Park III (24-14) | 35-32 | Won 2 |
| » Starters: Howie Pollet vs Red Munger | Third | 7½ out |
| Future Cardinal Jim Otten is born in Lewistown, MT. |
| Monday, July 2 |
| » Defeated Reds (32-36), 8-2 | Crosley Field (2-3) | 36-32 | Won 3 |
| » Starters: Max Lanier vs Harry Perkowski | Third | 7½ out |
| Tuesday, July 3 |
| » Lost to Reds (33-36), 10-4 | Crosley Field (2-4) | 36-33 | |
| » Starters: Harry Brecheen vs Ken Raffensberger | Third | 7½ out |
| » Major-league debuts: Jack Crimian (Cardinals) |
| Wednesday, July 4 |
| » Defeated Cubs (30-36), 10-5 | Wrigley Field (3-1) | 37-33 | |
| » Starters: Tom Poholsky vs Cal McLish | Third | 8 out |
| Thursday, July 5 |
| » Defeated Cubs (30-37), 10-2 | Wrigley Field (4-1) | 38-33 | Won 2 |
| » Starters: Cliff Chambers vs Johnny Klippstein | Third | 8 out |
| Friday, July 6 |
| » Defeated Pirates (29-44), 3-2 | Forbes Field (1-1) | 39-33 | Won 3 |
| » Starters: Red Munger vs Murry Dickson | Third | 8 out |
| Saturday, July 7 |
| » Lost to Pirates (30-44), 5-1 | Forbes Field (1-2) | 39-34 | |
| » Starters: Max Lanier vs Vern Law | Third | 9 out |
| Sunday, July 8 |
| » Lost to Pirates (31-44), 6-2 | Forbes Field (1-3) | 39-35 | Lost 2 |
| » Starters: Gerry Staley vs Bob Friend | Third | 9½ out |
| » Defeated Pirates (31-45), 9-8 | Forbes Field (2-3) | 40-35 | |
| » Starters: Tom Poholsky vs Bill Werle | Third | 9½ out |
| Thursday, July 12 |
| » Defeated Giants (44-37), 2-0 | Polo Grounds V (3-4) | 41-35 | Won 2 |
| » Starters: Gerry Staley vs Larry Jansen | Third | 9½ out |
| Friday, July 13 |
| » Lost to Giants (45-37), 14-4 | Polo Grounds V (3-5) | 41-36 | |
| » Starters: Red Munger vs Dave Koslo | Third | 10½ out |
| Saturday, July 14 |
| » Defeated Giants (45-38), 4-3 | Polo Grounds V (4-5) | 42-36 | |
| » Starters: Max Lanier vs Monte Kennedy | Third | 9 out |
| Sunday, July 15 |
| » Defeated Phillies (38-42), 7-4 | Shibe Park (3-3) | 43-36 | Won 2 |
| » Starters: Harry Brecheen vs Ken Johnson | Third | 8 out |
| » Lost to Phillies (39-42), 6-4 | Shibe Park (3-4) | 43-37 | |
| » Starters: Tom Poholsky vs Ken Heintzelman | Third | 8 out |
| Monday, July 16 |
| » Lost to Phillies (40-42), 5-2 | Shibe Park (3-5) | 43-38 | Lost 2 |
| » Starters: Gerry Staley vs Russ Meyer | Third | 9 out |
| Tuesday, July 17 |
| » Lost to Braves (37-43), 5-0 | Braves Field (3-3) | 43-39 | Lost 3 |
| » Starters: Red Munger vs Max Surkont | Third | 9 out |
| Wednesday, July 18 |
| » Defeated Braves (37-44), 9-6 | Braves Field (4-3) | 44-39 | |
| » Starters: Joe Presko vs Johnny Sain | Third | 8 out |
| Friday, July 20 |
| » Lost to Dodgers (54-32), 5-2 | Ebbets Field (1-5) | 44-40 | |
| » Starters: Max Lanier vs Preacher Roe | Third | 9 out |
| Saturday, July 21 |
| » Lost to Dodgers (55-32), 3-2 | Ebbets Field (1-6) | 44-41 | Lost 2 |
| » Starters: Gerry Staley vs Don Newcombe | Third | 10 out |
| Sunday, July 22 |
| » Lost to Dodgers (56-32), 9-2 | Ebbets Field (1-7) | 44-42 | Lost 3 |
| » Starters: Joe Presko vs Carl Erskine | Third | 11 out |
| Tuesday, July 24 |
| » Defeated Phillies (45-46), 9-5 | Sportsman's Park III (25-14) | 45-42 | |
| » Starters: Russ Meyer vs Harry Brecheen | Third | 11 out |
| Wednesday, July 25 |
| » Lost to Phillies (46-46), 2-0 | Sportsman's Park III (25-15) | 45-43 | |
| » Starters: Robin Roberts vs Max Lanier | Third | 12 out |
| Thursday, July 26 |
| » Lost to Phillies (47-46), 7-0 | Sportsman's Park III (25-16) | 45-44 | Lost 2 |
| » Starters: Ken Johnson vs Tom Poholsky | Third | 13 out |
| Friday, July 27 |
| » Lost to Dodgers (60-32), 12-9 | Sportsman's Park III (25-17) | 45-45 | Lost 3 |
| » Starters: Carl Erskine vs Gerry Staley | Fourth | 14 out |
| Saturday, July 28 |
| » Lost to Dodgers (61-32), 3-2 | Sportsman's Park III (25-18) | 45-46 | Lost 4 |
| » Starters: Ralph Branca vs Cloyd Boyer | Fourth | 15 out |
| Sunday, July 29 |
| » Lost to Dodgers (62-32), 9-3 | Sportsman's Park III (25-19) | 45-47 | Lost 5 |
| » Starters: Preacher Roe vs Harry Brecheen | Fourth | 16 out |
| Future Cardinal Dan Driessen is born in Hilton Head Island, SC. |
| Monday, July 30 |
| » Defeated Braves (44-49), 4-3 | Sportsman's Park III (26-19) | 46-47 | |
| » Starters: Vern Bickford vs Cliff Chambers | Fourth | 15½ out |
| Tuesday, July 31 |
| » Lost to Braves (45-49), 6-0 | Sportsman's Park III (26-20) | 46-48 | |
| » Starters: Chet Nichols vs Max Lanier | Fourth | 16½ out |
| Wednesday, August 1 |
| » Lost to Braves (46-49), 2-1 | Sportsman's Park III (26-21) | 46-49 | Lost 2 |
| » Starters: Warren Spahn vs Gerry Staley | Fourth | 16½ out |
| Thursday, August 2 |
| » Lost to Braves (47-49), 7-4 | Sportsman's Park III (26-22) | 46-50 | Lost 3 |
| » Starters: Max Surkont vs Cloyd Boyer | Fifth | 17½ out |
| Friday, August 3 |
| » Defeated Giants (57-47), 5-4 | Sportsman's Park III (27-22) | 47-50 | |
| » Starters: Sal Maglie vs Harry Brecheen | Fourth | 16½ out |
| Saturday, August 4 |
| » Lost to Giants (58-47), 10-0 | Sportsman's Park III (27-23) | 47-51 | |
| » Starters: Dave Koslo vs Cliff Chambers | Fourth | 16½ out |
| Sunday, August 5 |
| » Lost to Giants (59-47), 8-4 | Sportsman's Park III (27-24) | 47-52 | Lost 2 |
| » Starters: Al Corwin vs Gerry Staley | Fifth | 18 out |
| Tuesday, August 7 |
| » Defeated Pirates (41-62), 16-7 | Sportsman's Park III (28-24) | 48-52 | |
| » Starters: Paul LaPalme vs Cloyd Boyer | Fourth | 17½ out |
| Wednesday, August 8 |
| » Lost to Pirates (42-62), 10-7 | Sportsman's Park III (28-25) | 48-53 | |
| » Starters: Murry Dickson vs Tom Poholsky | Fifth | 19 out |
| Thursday, August 9 |
| » Defeated Pirates (42-63), 4-0 | Sportsman's Park III (29-25) | 49-53 | |
| » Starters: Howie Pollet vs Cliff Chambers | Fifth | 19 out |
| Future Cardinal Steve Swisher is born in Parkersburg, WV. |
| Friday, August 10 |
| » Defeated Reds (49-57), 4-3 | Sportsman's Park III (30-25) | 50-53 | Won 2 |
| » Starters: Ken Raffensberger vs Harry Brecheen | Fourth | 18½ out |
| Former Cardinal Win Kellum dies in Big Rapids, MI at the age of 76. |
| Saturday, August 11 |
| » Defeated Reds (49-58), 2-0 | Sportsman's Park III (31-25) | 51-53 | Won 3 |
| » Starters: Willie Ramsdell vs Max Lanier | Fourth | 18 out |
| Sunday, August 12 |
| » Defeated Reds (49-59), 4-3 | Sportsman's Park III (32-25) | 52-53 | Won 4 |
| » Starters: Herm Wehmeier vs Cloyd Boyer | Fourth | 18 out |
| Monday, August 13 |
| » Lost to Cubs (48-60), 6-3 | Sportsman's Park III (32-26) | 52-54 | |
| » Starters: Frank Hiller vs Dick Bokelmann | Fourth | 19 out |
| Tuesday, August 14 |
| » Lost to Cubs (49-60), 5-4 | Sportsman's Park III (32-27) | 52-55 | Lost 2 |
| » Starters: Turk Lown vs Cliff Chambers | Fourth | 19 out |
| Wednesday, August 15 |
| » Lost to Pirates (46-67), 7-0 | Forbes Field (2-4) | 52-56 | Lost 3 |
| » Starters: Gerry Staley vs Bob Friend | Fifth | 19 out |
| Thursday, August 16 |
| » Defeated Pirates (46-68), 9-6 | Forbes Field (3-4) | 53-56 | |
| » Starters: Tom Poholsky vs Murry Dickson | Fourth | 18 out |
| Friday, August 17 |
| » Defeated Reds (52-61), 2-1 | Crosley Field (3-4) | 54-56 | Won 2 |
| » Starters: Max Lanier vs Herm Wehmeier | Fourth | 17½ out |
| Former Cardinal Doc Crandall dies in Bell, CA at the age of 64. |
| Saturday, August 18 |
| » Lost to Reds (53-61), 1-0 | Crosley Field (3-5) | 54-57 | |
| » Starters: Harry Brecheen vs Ewell Blackwell | Fourth | 18½ out |
| Sunday, August 19 |
| » Defeated Reds (53-62), 5-4 | Crosley Field (4-5) | 55-57 | |
| » Starters: Cliff Chambers vs Ken Raffensberger | Third | 17 out |
| » Defeated Reds (53-63), 5-1 | Crosley Field (5-5) | 56-57 | Won 2 |
| » Starters: Al Brazle vs Howie Fox | Third | 17 out |
| Wednesday, August 22 |
| » Lost to Dodgers (75-41), 4-3 | Ebbets Field (1-8) | 56-58 | |
| » Starters: Tom Poholsky vs Preacher Roe | Fifth | 19 out |
| » Lost to Dodgers (76-41), 8-7 | Ebbets Field (1-9) | 56-59 | Lost 2 |
| » Starters: Gerry Staley vs Carl Erskine | Fifth | 19 out |
| Thursday, August 23 |
| » Defeated Dodgers (76-42), 4-2 | Ebbets Field (2-9) | 57-59 | |
| » Starters: Max Lanier vs Don Newcombe | Fourth | 18 out |
| Friday, August 24 |
| » Lost to Giants (71-51), 6-5 | Polo Grounds V (4-6) | 57-60 | |
| » Starters: Harry Brecheen vs Dave Koslo | Fifth | 19 out |
| Sunday, August 26 |
| » Defeated Braves (60-60), 12-10 | Braves Field (5-3) | 58-60 | |
| » Starters: Cliff Chambers vs Max Surkont | Fifth | 18½ out |
| » Lost to Braves (61-60), 9-1 | Braves Field (5-4) | 58-61 | |
| » Starters: Al Brazle vs Jim Wilson | Fifth | 18½ out |
| Monday, August 27 |
| » Lost to Braves (62-60), 6-3 | Braves Field (5-5) | 58-62 | Lost 2 |
| » Starters: Tom Poholsky vs Warren Spahn | Fifth | 19½ out |
| » Lost to Braves (63-60), 4-2 | Braves Field (5-6) | 58-63 | Lost 3 |
| » Starters: Red Munger vs Max Surkont | Fifth | 19½ out |
| Tuesday, August 28 |
| » Defeated Phillies (63-64), 2-0 | Shibe Park (4-5) | 59-63 | |
| » Starters: Max Lanier vs Bubba Church | Fifth | 19½ out |
| Future Cardinal Joel Youngblood is born in Houston, TX. |
| Wednesday, August 29 |
| » Defeated Phillies (63-65), 3-2 | Shibe Park (5-5) | 60-63 | Won 2 |
| » Starters: Gerry Staley vs Robin Roberts | Fifth | 19½ out |
| Thursday, August 30 |
| » Defeated Phillies (63-66), 6-3 | Shibe Park (6-5) | 61-63 | Won 3 |
| » Starters: Al Brazle vs Niles Jordan | Fourth | 19½ out |
| Saturday, September 1 |
| » Defeated Pirates (55-75), 6-2 | Sportsman's Park III (33-27) | 62-63 | Won 4 |
| » Starters: Don Carlsen vs Cliff Chambers | Fourth | 18½ out |
| Sunday, September 2 |
| » Defeated Pirates (55-76), 6-1 | Sportsman's Park III (34-27) | 63-63 | Won 5 |
| » Starters: Howie Pollet vs Tom Poholsky | Fourth | 17½ out |
| Monday, September 3 |
| » Defeated Reds (56-76), 4-1 | Sportsman's Park III (35-27) | 64-63 | Won 6 |
| » Starters: Ewell Blackwell vs Max Lanier | Fourth | 17½ out |
| » Defeated Reds (56-77), 7-1 | Sportsman's Park III (36-27) | 65-63 | Won 7 |
| » Starters: Willie Ramsdell vs Al Brazle | Fourth | 17½ out |
| Tuesday, September 4 |
| Former Cardinal Carl Doyle dies in Knoxville, TN at the age of 40. |
| Wednesday, September 5 |
| » Lost to Cubs (56-76), 3-2 | Wrigley Field (4-2) | 65-64 | |
| » Starters: Harry Brecheen vs Bob Kelly | Third | 18 out |
| » Defeated Cubs (56-77), 6-5 | Wrigley Field (5-2) | 66-64 | |
| » Starters: Gerry Staley vs Joe Hatten | Third | 18 out |
| Thursday, September 6 |
| » Defeated Cubs (56-78), 10-2 | Wrigley Field (6-2) | 67-64 | Won 2 |
| » Starters: Cliff Chambers vs Cal McLish | Third | 17½ out |
| Friday, September 7 |
| » Defeated Pirates (57-79), 11-4 | Forbes Field (4-4) | 68-64 | Won 3 |
| » Starters: Tom Poholsky vs Don Carlsen | Third | 17½ out |
| Saturday, September 8 |
| » Defeated Pirates (57-80), 4-2 | Forbes Field (5-4) | 69-64 | Won 4 |
| » Starters: Al Brazle vs Mel Queen | Third | 17½ out |
| Sunday, September 9 |
| » Defeated Pirates (57-81), 2-1 | Forbes Field (6-4) | 70-64 | Won 5 |
| » Starters: Max Lanier vs Murry Dickson | Third | 16 out |
| » Defeated Pirates (57-82), 7-4 | Forbes Field (7-4) | 71-64 | Won 6 |
| » Starters: Red Munger vs Vern Law | Third | 16 out |
| Tuesday, September 11 |
| » Lost to Giants (84-55), 10-5 | Sportsman's Park III (36-28) | 71-65 | |
| » Starters: Dave Koslo vs Gerry Staley | Third | 16½ out |
| » Defeated Giants (84-56), 4-3 | Sportsman's Park III (37-28) | 72-65 | |
| » Starters: Larry Jansen vs Cliff Chambers | Third | 16½ out |
| Thursday, September 13 |
| » Defeated Giants (84-57), 6-4 | Sportsman's Park III (38-28) | 73-65 | Won 2 |
| » Starters: Sal Maglie vs Tom Poholsky | Third | 16 out |
| » Lost to Braves (71-68), 2-0 | Sportsman's Park III (38-29) | 73-66 | |
| » Starters: Warren Spahn vs Al Brazle | Third | 16 out |
| Friday, September 14 |
| » Lost to Braves (72-68), 6-5 | Sportsman's Park III (38-30) | 73-67 | Lost 2 |
| » Starters: Chet Nichols vs Max Lanier | Third | 17 out |
| Former Cardinal Wally Roettger dies in Champaign, IL at the age of 50. |
| Saturday, September 15 |
| » Defeated Braves (72-69), 10-1 | Sportsman's Park III (39-30) | 74-67 | |
| » Starters: Dave Cole vs Cliff Chambers | Third | 16 out |
| Sunday, September 16 |
| » Defeated Phillies (68-75), 9-2 | Sportsman's Park III (40-30) | 75-67 | Won 2 |
| » Starters: Ken Johnson vs Gerry Staley | Third | 16 out |
| Monday, September 17 |
| » Lost to Phillies (69-75), 2-1 | Sportsman's Park III (40-31) | 75-68 | |
| » Starters: Robin Roberts vs Al Brazle | Third | 16 out |
| Tuesday, September 18 |
| » Defeated Dodgers (90-52), 7-1 | Sportsman's Park III (41-31) | 76-68 | |
| » Starters: Ralph Branca vs Tom Poholsky | Third | 15 out |
| Future Cardinal Tony Scott is born in Cincinnati, OH. |
| Wednesday, September 19 |
| » Lost to Dodgers (91-52), 3-0 | Sportsman's Park III (41-32) | 76-69 | |
| » Starters: Preacher Roe vs Max Lanier | Third | 16 out |
| Thursday, September 20 |
| » Lost to Dodgers (92-52), 4-3 | Sportsman's Park III (41-33) | 76-70 | Lost 2 |
| » Starters: Carl Erskine vs Cliff Chambers | Third | 17 out |
| Friday, September 21 |
| » Defeated Cubs (60-87), 6-0 | Sportsman's Park III (42-33) | 77-70 | |
| » Starters: Frank Hiller vs Jackie Collum | Third | 16 out |
| » Major-league debuts: Jackie Collum (Cardinals) |
| Saturday, September 22 |
| » Lost to Cubs (61-87), 6-5 | Sportsman's Park III (42-34) | 77-71 | |
| » Starters: Paul Minner vs Al Brazle | Third | 16 out |
| Sunday, September 23 |
| » Defeated Cubs (61-88), 9-3 | Sportsman's Park III (43-34) | 78-71 | |
| » Starters: Bob Kelly vs Tom Poholsky | Third | 15½ out |
| » Defeated Cubs (61-89), 5-2 | Sportsman's Park III (44-34) | 79-71 | Won 2 |
| » Starters: Joe Hatten vs Gerry Staley | Third | 15½ out |
| Tuesday, September 25 |
|