| Tuesday, January 2 |
| Future Athletic Jim Essian is born in Detroit, MI. |
| Wednesday, January 10 |
| Former Athletic Tom Delahanty dies in Sanford, FL at the age of 79. |
| Tuesday, April 17 |
| » Lost to Senators (1-0), 6-1 | Shibe Park (0-1) | 0-1 | |
| » Starters: Connie Marrero vs Bobby Shantz | Second | 1 out |
| Wednesday, April 18 |
| » Lost to Senators (2-0), 6-4 | Shibe Park (0-2) | 0-2 | Lost 2 |
| » Starters: Bob Kuzava vs Lou Brissie | Fourth | 2 out |
| Friday, April 20 |
| » Defeated Red Sox (0-3), 6-3 | Fenway Park (1-0) | 1-2 | |
| » Starters: Alex Kellner vs Mel Parnell | Fourth | 2½ out |
| Saturday, April 21 |
| » Lost to Red Sox (1-3), 6-3 | Fenway Park (1-1) | 1-3 | |
| » Starters: Bob Hooper vs Chuck Stobbs | Fourth | 2½ out |
| Sunday, April 22 |
| » Lost to Red Sox (2-3), 6-5 | Fenway Park (1-2) | 1-4 | Lost 2 |
| » Starters: Dick Fowler vs Ray Scarborough | Sixth | 4 out |
| » Lost to Red Sox (3-3), 7-4 | Fenway Park (1-3) | 1-5 | Lost 3 |
| » Starters: Hank Wyse vs Willard Nixon | Sixth | 4 out |
| Monday, April 23 |
| » Lost to Yankees (4-2), 5-4 | Yankee Stadium (0-1) | 1-6 | Lost 4 |
| » Starters: Lou Brissie vs Vic Raschi | Sixth | 4½ out |
| Tuesday, April 24 |
| » Lost to Yankees (5-2), 3-0 | Yankee Stadium (0-2) | 1-7 | Lost 5 |
| » Starters: Bobby Shantz vs Ed Lopat | Eighth | 5½ out |
| Wednesday, April 25 |
| » Lost to Yankees (6-2), 4-0 | Yankee Stadium (0-3) | 1-8 | Lost 6 |
| » Starters: Alex Kellner vs Spec Shea | Eighth | 6 out |
| Thursday, April 26 |
| » Lost to Senators (6-1), 2-1 | Griffith Stadium (0-1) | 1-9 | Lost 7 |
| » Starters: Joe Coleman vs Connie Marrero | Seventh | 6½ out |
| Friday, April 27 |
| » Lost to Senators (7-1), 6-1 | Griffith Stadium (0-2) | 1-10 | Lost 8 |
| » Starters: Carl Scheib vs Sandy Consuegra | Eighth | 7½ out |
| Saturday, April 28 |
| » Lost to Red Sox (6-4), 4-2 | Shibe Park (0-3) | 1-11 | Lost 9 |
| » Starters: Chuck Stobbs vs Bob Hooper | Eighth | 8 out |
| Sunday, April 29 |
| » Lost to Red Sox (7-4), 12-8 | Shibe Park (0-4) | 1-12 | Lost 10 |
| » Starters: Ray Scarborough vs Alex Kellner | Seventh | 7½ out |
| Monday, April 30 |
| » Major-league debuts: Earl Mossor (Dodgers) |
| Tuesday, May 1 |
| » Defeated Tigers (3-6), 9-1 | Tiger Stadium (1-0) | 2-12 | |
| » Starters: Carl Scheib vs Dizzy Trout | Seventh | 7½ out |
| Wednesday, May 2 |
| » Lost to Tigers (4-6), 5-4 | Tiger Stadium (1-1) | 2-13 | |
| » Starters: Joe Coleman vs Saul Rogovin | Seventh | 8½ out |
| Friday, May 4 |
| » Defeated Indians (9-4), 3-1 | Cleveland Stadium (1-0) | 3-13 | |
| » Starters: Alex Kellner vs Early Wynn | Eighth | 9 out |
| Saturday, May 5 |
| » Lost to Indians (10-4), 3-2 | Cleveland Stadium (1-1) | 3-14 | |
| » Starters: Dick Fowler vs Mike Garcia | Eighth | 10 out |
| Sunday, May 6 |
| » Lost to White Sox (9-7), 4-1 | Comiskey Park I (0-1) | 3-15 | Lost 2 |
| » Starters: Carl Scheib vs Ken Holcombe | Eighth | 11½ out |
| » Lost to White Sox (10-7), 8-3 | Comiskey Park I (0-2) | 3-16 | Lost 3 |
| » Starters: Joe Coleman vs Lou Kretlow | Eighth | 11½ out |
| Tuesday, May 8 |
| » Defeated White Sox (10-8), 9-4 | Comiskey Park I (1-2) | 4-16 | |
| » Starters: Bobby Shantz vs Dick Littlefield | Eighth | 10 out |
| Wednesday, May 9 |
| » Defeated Browns (5-16), 8-2 | Sportsman's Park III (1-0) | 5-16 | Won 2 |
| » Starters: Alex Kellner vs Stubby Overmire | Seventh | 10 out |
| Saturday, May 12 |
| » Lost to Yankees (16-6), 8-4 | Shibe Park (0-5) | 5-17 | |
| » Starters: Vic Raschi vs Dick Fowler | Seventh | 11 out |
| Sunday, May 13 |
| » Defeated Yankees (16-7), 5-4 | Shibe Park (1-5) | 6-17 | |
| » Starters: Allie Reynolds vs Alex Kellner | Fifth | 9 out |
| » Defeated Yankees (16-8), 9-6 | Shibe Park (2-5) | 7-17 | Won 2 |
| » Starters: Spec Shea vs Joe Coleman | Fifth | 9 out |
| Tuesday, May 15 |
| » Lost to Browns (7-19), 11-8 | Shibe Park (2-6) | 7-18 | |
| » Starters: Dick Starr vs Bobby Shantz | Sixth | 10 out |
| Wednesday, May 16 |
| » Lost to Browns (8-19), 10-9 | Shibe Park (2-7) | 7-19 | Lost 2 |
| » Starters: Cliff Fannin vs Carl Scheib | Seventh | 11 out |
| Thursday, May 17 |
| » Defeated Browns (8-20), 7-6 | Shibe Park (3-7) | 8-19 | |
| » Starters: Don Johnson vs Joe Coleman | Sixth | 11 out |
| Friday, May 18 |
| » Lost to Tigers (15-10), 9-6 | Shibe Park (3-8) | 8-20 | |
| » Starters: Ted Gray vs Alex Kellner | Seventh | 11 out |
| Sunday, May 20 |
| » Defeated Indians (12-15), 2-1 | Shibe Park (4-8) | 9-20 | |
| » Starters: Bob Lemon vs Dick Fowler | Seventh | 11½ out |
| » Lost to Indians (13-15), 5-3 | Shibe Park (4-9) | 9-21 | |
| » Starters: Bob Chakales vs Morrie Martin | Seventh | 11½ out |
| Tuesday, May 22 |
| » Lost to Indians (14-15), 6-2 | Shibe Park (4-10) | 9-22 | Lost 2 |
| » Starters: Early Wynn vs Bobby Shantz | Seventh | 13 out |
| Thursday, May 24 |
| » Lost to White Sox (19-9), 5-2 | Shibe Park (4-11) | 9-23 | Lost 3 |
| » Starters: Randy Gumpert vs Joe Coleman | Sixth | 14 out |
| Friday, May 25 |
| » Lost to Yankees (24-9), 7-5 | Yankee Stadium (0-4) | 9-24 | Lost 4 |
| » Starters: Alex Kellner vs Ed Lopat | Sixth | 15 out |
| Saturday, May 26 |
| » Lost to Yankees (25-9), 8-5 | Yankee Stadium (0-5) | 9-25 | Lost 5 |
| » Starters: Dick Fowler vs Vic Raschi | Seventh | 16 out |
| Sunday, May 27 |
| » Lost to Yankees (26-9), 9-0 | Yankee Stadium (0-6) | 9-26 | Lost 6 |
| » Starters: Morrie Martin vs Spec Shea | Seventh | 16 out |
| » Defeated Yankees (26-10), 7-4 | Yankee Stadium (1-6) | 10-26 | |
| » Starters: Bobby Shantz vs Fred Sanford | Seventh | 16 out |
| Wednesday, May 30 |
| » Defeated Senators (15-20), 9-5 | Griffith Stadium (1-2) | 11-26 | Won 2 |
| » Starters: Joe Coleman vs Sid Hudson | Seventh | 16½ out |
| » Lost to Senators (16-20), 6-2 | Griffith Stadium (1-3) | 11-27 | |
| » Starters: Alex Kellner vs Connie Marrero | Seventh | 16½ out |
| Saturday, June 2 |
| » Defeated White Sox (26-10), 5-1 | Comiskey Park I (2-2) | 12-27 | |
| » Starters: Bob Hooper vs Joe Dobson | Seventh | 15½ out |
| Sunday, June 3 |
| » Defeated Browns (12-31), 7-3 | Sportsman's Park III (2-0) | 13-27 | Won 2 |
| » Starters: Dick Fowler vs Lou Sleater | Seventh | 15½ out |
| » Lost to Browns (13-31), 2-1 | Sportsman's Park III (2-1) | 13-28 | |
| » Starters: Carl Scheib vs Stubby Overmire | Seventh | 15½ out |
| Monday, June 4 |
| » Defeated Browns (13-32), 7-6 | Sportsman's Park III (3-1) | 14-28 | |
| » Starters: Joe Coleman vs Al Widmar | Seventh | 16 out |
| Tuesday, June 5 |
| » Lost to Browns (14-32), 10-1 | Sportsman's Park III (3-2) | 14-29 | |
| » Starters: Johnny Kucab vs Ned Garver | Seventh | 17 out |
| Wednesday, June 6 |
| » Defeated Indians (24-21), 4-3 | Cleveland Stadium (2-1) | 15-29 | |
| » Starters: Alex Kellner vs Bob Chakales | Seventh | 17 out |
| Thursday, June 7 |
| » Lost to Indians (25-21), 6-3 | Cleveland Stadium (2-2) | 15-30 | |
| » Starters: Bob Hooper vs Lou Brissie | Seventh | 18 out |
| Friday, June 8 |
| » Lost to Tigers (22-23), 9-2 | Tiger Stadium (1-2) | 15-31 | Lost 2 |
| » Starters: Carl Scheib vs Dizzy Trout | Seventh | 18 out |
| Saturday, June 9 |
| Future Athletic Dave Parker is born in Calhoun, MS. |
| Sunday, June 10 |
| » Lost to Tigers (23-23), 11-7 | Tiger Stadium (1-3) | 15-32 | Lost 3 |
| » Starters: Dick Fowler vs Hal Newhouser | Eighth | 18½ out |
| » Lost to Tigers (24-23), 9-5 | Tiger Stadium (1-4) | 15-33 | Lost 4 |
| » Starters: Joe Coleman vs Bob Cain | Eighth | 18½ out |
| Tuesday, June 12 |
| » Lost to Indians (28-23), 8-6 | Shibe Park (4-12) | 15-34 | Lost 5 |
| » Starters: Bob Feller vs Alex Kellner | Eighth | 19½ out |
| Thursday, June 14 |
| » Lost to Indians (29-23), 3-1 | Shibe Park (4-13) | 15-35 | Lost 6 |
| » Starters: Bob Lemon vs Sam Zoldak | Eighth | 21 out |
| Friday, June 15 |
| » Defeated White Sox (36-15), 4-3 | Shibe Park (5-13) | 16-35 | |
| » Starters: Saul Rogovin vs Bob Hooper | Eighth | 19 out |
| » Defeated White Sox (36-16), 12-5 | Shibe Park (6-13) | 17-35 | Won 2 |
| » Starters: Ken Holcombe vs Bobby Shantz | Eighth | 19 out |
| Saturday, June 16 |
| » Defeated White Sox (36-17), 6-5 | Shibe Park (7-13) | 18-35 | Won 3 |
| » Starters: Howie Judson vs Dick Fowler | Seventh | 18 out |
| Sunday, June 17 |
| » Lost to White Sox (37-17), 4-1 | Shibe Park (7-14) | 18-36 | |
| » Starters: Randy Gumpert vs Carl Scheib | Seventh | 20 out |
| » Lost to White Sox (38-17), 9-0 | Shibe Park (7-15) | 18-37 | Lost 2 |
| » Starters: Luis Aloma vs Alex Kellner | Seventh | 20 out |
| Tuesday, June 19 |
| » Defeated Tigers (26-27), 9-5 | Shibe Park (8-15) | 19-37 | |
| » Starters: Dizzy Trout vs Sam Zoldak | Seventh | 19½ out |
| Wednesday, June 20 |
| » Lost to Tigers (27-27), 7-2 | Shibe Park (8-16) | 19-38 | |
| » Starters: Fred Hutchinson vs Bob Hooper | Seventh | 19 out |
| » Defeated Tigers (27-28), 5-4 | Shibe Park (9-16) | 20-38 | |
| » Starters: Virgil Trucks vs Bobby Shantz | Seventh | 19 out |
| Thursday, June 21 |
| » Lost to Tigers (28-28), 9-3 | Shibe Park (9-17) | 20-39 | |
| » Starters: Bob Cain vs Carl Scheib | Seventh | 20 out |
| Friday, June 22 |
| » Defeated Browns (19-40), 5-2 | Shibe Park (10-17) | 21-39 | |
| » Starters: Al Widmar vs Alex Kellner | Seventh | 19 out |
| Saturday, June 23 |
| » Defeated Browns (19-41), 4-1 | Shibe Park (11-17) | 22-39 | Won 2 |
| » Starters: Tommy Byrne vs Dick Fowler | Seventh | 18 out |
| Sunday, June 24 |
| » Defeated Browns (19-42), 8-3 | Shibe Park (12-17) | 23-39 | Won 3 |
| » Starters: Dick Starr vs Sam Zoldak | Seventh | 17 out |
| » Defeated Browns (19-43), 7-1 | Shibe Park (13-17) | 24-39 | Won 4 |
| » Starters: Bill Kennedy vs Bobby Shantz | Seventh | 17 out |
| Tuesday, June 26 |
| » Lost to Red Sox (38-26), 13-5 | Fenway Park (1-4) | 24-40 | |
| » Starters: Bob Hooper vs Mel Parnell | Seventh | 18 out |
| Wednesday, June 27 |
| » Lost to Red Sox (39-26), 6-5 | Fenway Park (1-5) | 24-41 | Lost 2 |
| » Starters: Carl Scheib vs Ray Scarborough | Seventh | 18 out |
| » Major-league debuts: Leo Kiely (Red Sox) |
| Friday, June 29 |
| » Defeated Senators (25-38), 3-2 | Shibe Park (14-17) | 25-41 | |
| » Starters: Bob Porterfield vs Sam Zoldak | Seventh | 17½ out |
| » Defeated Senators (25-39), 11-5 | Shibe Park (15-17) | 26-41 | Won 2 |
| » Starters: Fred Sanford vs Alex Kellner | Seventh | 17½ out |
| Sunday, July 1 |
| » Defeated Senators (25-40), 10-7 | Shibe Park (16-17) | 27-41 | Won 3 |
| » Starters: Don Johnson vs Dick Fowler | Sixth | 16 out |
| » Defeated Senators (25-41), 3-2 | Shibe Park (17-17) | 28-41 | Won 4 |
| » Starters: Julio Moreno vs Bob Hooper | Sixth | 16 out |
| » Major-league debuts: Pete Runnels (Senators) |
| Monday, July 2 |
| » Lost to Yankees (44-24), 14-5 | Shibe Park (17-18) | 28-42 | |
| » Starters: Allie Reynolds vs Bobby Shantz | Sixth | 17 out |
| Wednesday, July 4 |
| » Lost to Red Sox (42-29), 9-0 | Shibe Park (17-19) | 28-43 | Lost 2 |
| » Starters: Mickey McDermott vs Sam Zoldak | Seventh | 17½ out |
| » Lost to Red Sox (43-29), 9-5 | Shibe Park (17-20) | 28-44 | Lost 3 |
| » Starters: Willard Nixon vs Carl Scheib | Seventh | 17½ out |
| Thursday, July 5 |
| » Lost to Red Sox (44-29), 8-3 | Shibe Park (17-21) | 28-45 | Lost 4 |
| » Starters: Chuck Stobbs vs Bob Hooper | Seventh | 18 out |
| Future Athletic Goose Gossage is born in Colorado Springs, CO. |
| Friday, July 6 |
| » Lost to Senators (29-43), 6-3 | Griffith Stadium (1-4) | 28-46 | Lost 5 |
| » Starters: Bobby Shantz vs Don Johnson | Seventh | 18 out |
| Saturday, July 7 |
| » Defeated Senators (29-44), 4-3 | Griffith Stadium (2-4) | 29-46 | |
| » Starters: Dick Fowler vs Julio Moreno | Seventh | 18 out |
| Sunday, July 8 |
| » Lost to Senators (30-44), 3-1 | Griffith Stadium (2-5) | 29-47 | |
| » Starters: Alex Kellner vs Connie Marrero | Seventh | 19½ out |
| » Lost to Senators (31-44), 8-2 | Griffith Stadium (2-6) | 29-48 | Lost 2 |
| » Starters: Carl Scheib vs Sid Hudson | Seventh | 19½ out |
| Thursday, July 12 |
| » Defeated Browns (22-53), 9-7 | Sportsman's Park III (4-2) | 30-48 | |
| » Starters: Alex Kellner vs Al Widmar | Seventh | 18½ out |
| » Defeated Browns (22-54), 13-0 | Sportsman's Park III (5-2) | 31-48 | Won 2 |
| » Starters: Bobby Shantz vs Dick Starr | Seventh | 18½ out |
| Friday, July 13 |
| » Lost to Browns (23-54), 5-0 | Sportsman's Park III (5-3) | 31-49 | |
| » Starters: Dick Fowler vs Duane Pillette | Seventh | 18½ out |
| Saturday, July 14 |
| » Defeated Browns (23-55), 10-6 | Sportsman's Park III (6-3) | 32-49 | |
| » Starters: Morrie Martin vs Jim Suchecki | Seventh | 18½ out |
| Sunday, July 15 |
| » Defeated White Sox (50-33), 3-1 | Comiskey Park I (3-2) | 33-49 | Won 2 |
| » Starters: Bob Hooper vs Randy Gumpert | Seventh | 17½ out |
| » Defeated White Sox (50-34), 5-0 | Comiskey Park I (4-2) | 34-49 | Won 3 |
| » Starters: Sam Zoldak vs Howie Judson | Seventh | 17½ out |
| Monday, July 16 |
| » Lost to White Sox (51-34), 9-5 | Comiskey Park I (4-3) | 34-50 | |
| » Starters: Bobby Shantz vs Joe Dobson | Seventh | 17½ out |
| Tuesday, July 17 |
| » Lost to Tigers (37-42), 8-5 | Tiger Stadium (1-5) | 34-51 | Lost 2 |
| » Starters: Alex Kellner vs Virgil Trucks | Seventh | 17½ out |
| Wednesday, July 18 |
| » Defeated Tigers (37-43), 16-9 | Tiger Stadium (2-5) | 35-51 | |
| » Starters: Dick Fowler vs Ted Gray | Seventh | 17½ out |
| Thursday, July 19 |
| » Defeated Tigers (37-44), 5-0 | Tiger Stadium (3-5) | 36-51 | Won 2 |
| » Starters: Morrie Martin vs Fred Hutchinson | Seventh | 17 out |
| » Lost to Tigers (38-44), 4-3 | Tiger Stadium (3-6) | 36-52 | |
| » Starters: Bob Hooper vs Hank Borowy | Seventh | 17 out |
| Friday, July 20 |
| » Lost to Indians (51-35), 1-0 | Cleveland Stadium (2-3) | 36-53 | Lost 2 |
| » Starters: Sam Zoldak vs Mike Garcia | Seventh | 17 out |
| Saturday, July 21 |
| » Lost to Indians (52-35), 5-3 | Cleveland Stadium (2-4) | 36-54 | Lost 3 |
| » Starters: Bobby Shantz vs Bob Feller | Seventh | 18 out |
| Sunday, July 22 |
| » Lost to Indians (53-35), 6-4 | Cleveland Stadium (2-5) | 36-55 | Lost 4 |
| » Starters: Dick Fowler vs Bob Lemon | Sixth | 19½ out |
| » Lost to Indians (54-35), 3-1 | Cleveland Stadium (2-6) | 36-56 | Lost 5 |
| » Starters: Alex Kellner vs Steve Gromek | Sixth | 19½ out |
| Wednesday, July 25 |
| » Lost to Browns (28-62), 5-4 | Shibe Park (17-22) | 36-57 | Lost 6 |
| » Starters: Ned Garver vs Sam Zoldak | Seventh | 21 out |
| Thursday, July 26 |
| » Lost to Browns (29-62), 6-4 | Shibe Park (17-23) | 36-58 | Lost 7 |
| » Starters: Duane Pillette vs Morrie Martin | Seventh | 21 out |
| Friday, July 27 |
| » Defeated Tigers (41-48), 10-6 | Shibe Park (18-23) | 37-58 | |
| » Starters: Virgil Trucks vs Bob Hooper | Sixth | 21 out |
| Saturday, July 28 |
| » Lost to Tigers (42-48), 6-5 | Shibe Park (18-24) | 37-59 | |
| » Starters: Marlin Stuart vs Dick Fowler | Seventh | 21½ out |
| Sunday, July 29 |
| » Lost to Tigers (43-48), 8-4 | Shibe Park (18-25) | 37-60 | Lost 2 |
| » Starters: Dizzy Trout vs Sam Zoldak | Sixth | 22½ out |
| » Defeated Tigers (43-49), 3-0 | Shibe Park (19-25) | 38-60 | |
| » Starters: Hal White vs Bobby Shantz | Sixth | 22½ out |
| Tuesday, July 31 |
| » Defeated White Sox (54-45), 4-2 | Shibe Park (20-25) | 39-60 | Won 2 |
| » Starters: Ken Holcombe vs Alex Kellner | Seventh | 22½ out |
| Wednesday, August 1 |
| » Lost to White Sox (55-45), 4-3 | Shibe Park (20-26) | 39-61 | |
| » Starters: Billy Pierce vs Morrie Martin | Seventh | 23 out |
| Thursday, August 2 |
| » Lost to White Sox (56-45), 4-3 | Shibe Park (20-27) | 39-62 | Lost 2 |
| » Starters: Randy Gumpert vs Bob Hooper | Sixth | 23 out |
| Friday, August 3 |
| » Lost to Indians (61-39), 3-2 | Shibe Park (20-28) | 39-63 | Lost 3 |
| » Starters: Mike Garcia vs Sam Zoldak | Sixth | 23½ out |
| Saturday, August 4 |
| » Lost to Indians (62-39), 4-2 | Shibe Park (20-29) | 39-64 | Lost 4 |
| » Starters: Bob Feller vs Dick Fowler | Seventh | 24½ out |
| Sunday, August 5 |
| » Lost to Indians (63-39), 6-3 | Shibe Park (20-30) | 39-65 | Lost 5 |
| » Starters: Bob Lemon vs Alex Kellner | Seventh | 26½ out |
| » Lost to Indians (64-39), 6-3 | Shibe Park (20-31) | 39-66 | Lost 6 |
| » Starters: Early Wynn vs Morrie Martin | Seventh | 26½ out |
| Tuesday, August 7 |
| » Defeated Red Sox (61-43), 7-4 | Fenway Park (2-5) | 40-66 | |
| » Starters: Bob Hooper vs Ray Scarborough | Seventh | 26½ out |
| Thursday, August 9 |
| » Defeated Red Sox (61-44), 6-5 | Fenway Park (3-5) | 41-66 | Won 2 |
| » Starters: Morrie Martin vs Mickey McDermott | Sixth | 26½ out |
| » Lost to Red Sox (62-44), 5-3 | Fenway Park (3-6) | 41-67 | |
| » Starters: Alex Kellner vs Leo Kiely | Sixth | 26½ out |
| Friday, August 10 |
| » Lost to Yankees (67-39), 3-1 | Shibe Park (20-32) | 41-68 | Lost 2 |
| » Starters: Ed Lopat vs Sam Zoldak | Sixth | 27½ out |
| Saturday, August 11 |
| » Lost to Yankees (68-39), 7-4 | Shibe Park (20-33) | 41-69 | Lost 3 |
| » Starters: Allie Reynolds vs Dick Fowler | Sixth | 28½ out |
| Sunday, August 12 |
| » Defeated Yankees (68-40), 9-5 | Shibe Park (21-33) | 42-69 | |
| » Starters: Tom Morgan vs Bob Hooper | Seventh | 28 out |
| » Defeated Yankees (68-41), 7-4 | Shibe Park (22-33) | 43-69 | Won 2 |
| » Starters: Bob Wiesler vs Bobby Shantz | Seventh | 28 out |
| Monday, August 13 |
| » Defeated Yankees (68-42), 16-8 | Shibe Park (23-33) | 44-69 | Won 3 |
| » Starters: Vic Raschi vs Morrie Martin | Seventh | 28 out |
| Tuesday, August 14 |
| » Lost to Red Sox (66-45), 7-4 | Shibe Park (23-34) | 44-70 | |
| » Starters: Mickey McDermott vs Sam Zoldak | Seventh | 29 out |
| Wednesday, August 15 |
| » Lost to Red Sox (67-45), 4-2 | Shibe Park (23-35) | 44-71 | Lost 2 |
| » Starters: Mel Parnell vs Dick Fowler | Seventh | 30 out |
| Thursday, August 16 |
| » Defeated Red Sox (67-46), 10-2 | Shibe Park (24-35) | 45-71 | |
| » Starters: Ray Scarborough vs Bobby Shantz | Seventh | 29 out |
| » Major-league debuts: Mel Hoderlein (Red Sox) |
| Friday, August 17 |
| » Lost to Yankees (72-42), 3-2 | Yankee Stadium (1-7) | 45-72 | |
| » Starters: Bob Hooper vs Stubby Overmire | Sixth | 28½ out |
| Saturday, August 18 |
| » Lost to Yankees (73-42), 5-1 | Yankee Stadium (1-8) | 45-73 | Lost 2 |
| » Starters: Alex Kellner vs Vic Raschi | Sixth | 29½ out |
| Sunday, August 19 |
| » Defeated Yankees (73-43), 15-1 | Yankee Stadium (2-8) | 46-73 | |
| » Starters: Morrie Martin vs Bob Wiesler | Seventh | 29 out |
| Tuesday, August 21 |
| » Lost to White Sox (65-53), 13-5 | Comiskey Park I (4-4) | 46-74 | |
| » Starters: Bobby Shantz vs Saul Rogovin | Seventh | 30½ out |
| Wednesday, August 22 |
| » Defeated White Sox (65-54), 5-2 | Comiskey Park I (5-4) | 47-74 | |
| » Starters: Bob Hooper vs Billy Pierce | Seventh | 30 out |
| » Defeated White Sox (65-55), 8-1 | Comiskey Park I (6-4) | 48-74 | Won 2 |
| » Starters: Sam Zoldak vs Joe Dobson | Seventh | 30 out |
| Thursday, August 23 |
| » Defeated White Sox (65-56), 6-3 | Comiskey Park I (7-4) | 49-74 | Won 3 |
| » Starters: Dick Fowler vs Randy Gumpert | Seventh | 30 out |
| Friday, August 24 |
| » Lost to Browns (38-81), 5-3 | Sportsman's Park III (6-4) | 49-75 | |
| » Starters: Alex Kellner vs Ned Garver | Seventh | 30 out |
| Saturday, August 25 |
| » Defeated Browns (38-82), 9-1 | Sportsman's Park III (7-4) | 50-75 | |
| » Starters: Morrie Martin vs Duane Pillette | Seventh | 29 out |
| Sunday, August 26 |
| » Lost to Tigers (58-65), 6-0 | Tiger Stadium (3-7) | 50-76 | |
| » Starters: Bob Hooper vs Fred Hutchinson | Seventh | 29½ out |
| Monday, August 27 |
| » Defeated Tigers (58-66), 1-0 | Tiger Stadium (4-7) | 51-76 | |
| » Starters: Bobby Shantz vs Marlin Stuart | Seventh | 29 out |
| Tuesday, August 28 |
| » Lost to Indians (80-46), 1-0 | Cleveland Stadium (2-7) | 51-77 | |
| » Starters: Sam Zoldak vs Early Wynn | Seventh | 30 out |
| Wednesday, August 29 |
| » Defeated Indians (80-47), 3-0 | Cleveland Stadium (3-7) | 52-77 | |
| » Starters: Alex Kellner vs Mike Garcia | Sixth | 29 out |
| Thursday, August 30 |
| » Defeated Indians (80-48), 6-2 | Cleveland Stadium (4-7) | 53-77 | Won 2 |
| » Starters: Morrie Martin vs Bob Feller | Seventh | 28½ out |
| Sunday, September 2 |
| » Major-league debuts: Bud Thomas (Browns) |
| Monday, September 3 |
| » Lost to Yankees (82-47), 3-1 | Shibe Park (24-36) | 53-78 | |
| » Starters: Johnny Sain vs Alex Kellner | Seventh | 29½ out |
| » Defeated Yankees (82-48), 3-2 | Shibe Park (25-36) | 54-78 | |
| » Starters: Tom Morgan vs Bobby Shantz | Seventh | 29½ out |
| Wednesday, September 5 |
| » Defeated Senators (53-76), 4-1 | Shibe Park (26-36) | 55-78 | Won 2 |
| » Starters: Connie Marrero vs Sam Zoldak | Sixth | 28½ out |
| » Defeated Senators (53-77), 9-7 | Shibe Park (27-36) | 56-78 | Won 3 |
| » Starters: Don Johnson vs Bob Hooper | Sixth | 28½ out |
| Former Athletic Jim Keesey dies in Boise, ID at the age of 49. |
| Friday, September 7 |
| » Lost to Red Sox (79-51), 8-5 | Shibe Park (27-37) | 56-79 | |
| » Starters: Bill Wight vs Morrie Martin | Sixth | 28 out |
| » Defeated Red Sox (79-52), 11-4 | Shibe Park (28-37) | 57-79 | |
| » Starters: Ray Scarborough vs Alex Kellner | Sixth | 28 out |
| Saturday, September 8 |
| » Lost to Red Sox (80-52), 6-1 | Shibe Park (28-38) | 57-80 | |
| » Starters: Mel Parnell vs Dick Fowler | Sixth | 29 out |
| Sunday, September 9 |
| » Defeated Red Sox (80-53), 10-4 | Shibe Park (29-38) | 58-80 | |
| » Starters: Mickey McDermott vs Bob Hooper | Sixth | 29 out |
| » Defeated Red Sox (80-54), 3-2 | Shibe Park (30-38) | 59-80 | Won 2 |
| » Starters: Chuck Stobbs vs Bobby Shantz | Sixth | 29 out |
| Tuesday, September 11 |
| » Lost to Indians (89-51), 6-5 | Shibe Park (30-39) | 59-81 | |
| » Starters: Mike Garcia vs Sam Zoldak | Sixth | 29 out |
| » Defeated Indians (89-52), 9-5 | Shibe Park (31-39) | 60-81 | |
| » Starters: Bob Feller vs Alex Kellner | Sixth | 29 out |
| Friday, September 14 |
| » Defeated White Sox (76-65), 3-0 | Shibe Park (32-39) | 61-81 | Won 2 |
| » Starters: Lou Kretlow vs Bobby Shantz | Sixth | 28 out |
| Saturday, September 15 |
| » Defeated White Sox (76-66), 5-4 | Shibe Park (33-39) | 62-81 | Won 3 |
| » Starters: Randy Gumpert vs Dick Fowler | Sixth | 27½ out |
| Sunday, September 16 |
| » Defeated Browns (44-96), 7-1 | Shibe Park (34-39) | 63-81 | Won 4 |
| » Starters: Duke Markell vs Bob Hooper | Sixth | 26 out |
| » Defeated Browns (44-97), 7-5 | Shibe Park (35-39) | 64-81 | Won 5 |
| » Starters: Jim McDonald vs Alex Kellner | Sixth | 26 out |
| Tuesday, September 18 |
| » Lost to Tigers (68-77), 8-6 | Shibe Park (35-40) | 64-82 | |
| » Starters: Virgil Trucks vs Sam Zoldak | Sixth | 26½ out |
| Wednesday, September 19 |
| » Defeated Tigers (68-78), 8-1 | Shibe Park (36-40) | 65-82 | |
| » Starters: Marlin Stuart vs Bobby Shantz | Sixth | 26½ out |
| » Major-league debuts: Dick Marlowe (Tigers) |
| Saturday, September 22 |
| » Lost to Senators (58-88), 9-1 | Shibe Park (36-41) | 65-83 | |
| » Starters: Dick Starr vs Dick Fowler | Sixth | 27½ out |
| Sunday, September 23 |
| » Defeated Senators (58-89), 12-4 | Shibe Park (37-41) | 66-83 | |
| » Starters: Connie Marrero vs Bob Hooper | Sixth | 27 out |
| » Defeated Senators (58-90), 8-3 | Shibe Park (38-41) | 67-83 | Won 2 |
| » Starters: Sandy Consuegra vs Sam Zoldak | Sixth | 27 out |
| Wednesday, September 26 |
| » Defeated Yankees (93-56), 4-1 | Yankee Stadium (3-8) | 68-83 | Won 3 |
| » Starters: Bobby Shantz vs Bob Kuzava | Sixth | 26 out |
| Saturday, September 29 |
| » Defeated Senators (61-91), 5-1 | Griffith Stadium (3-6) | 69-83 | Won 4 |
| » Starters: Alex Kellner vs Dick Starr | Sixth | 27½ out |
| Sunday, September 30 |
| » Lost to Senators (62-91), 4-2 | Griffith Stadium (3-7) | 69-84 | |
| » Starters: Bobby Shantz vs Bob Porterfield | Sixth | 28 out |
| » Defeated Senators (62-92), 4-3 | Griffith Stadium (4-7) | 70-84 | |
| » Starters: Bob Hooper vs Joe Haynes | Sixth | 28 out |
| Wednesday, December 5 |
| Former Athletic Joe Jackson dies in Greenville, SC at the age of 63. |
Game information provided by Retrosheet (www.retrosheet.org) |