| Tuesday, January 3 |
| Future White Sox Bart Johnson is born in Torrance, CA. |
| Wednesday, January 18 |
| Future White Sox Bill Sharp is born in Lima, OH. |
| Saturday, February 11 |
| Former White Sox Paul Meloan dies in Taft, CA at the age of 62. |
| Sunday, February 26 |
| Future White Sox Jack Brohamer is born in Maywood, CA. |
| Monday, March 27 |
| Future White Sox Lynn McGlothen is born in Monroe, LA. |
| Tuesday, April 11 |
| Former White Sox Dick McCabe dies in Buffalo, NY at the age of 55. |
| Tuesday, April 18 |
| » Lost to Browns (1-0), 5-3 | Comiskey Park I (0-1) | 0-1 | |
| » Starters: Ned Garver vs Bill Wight | Second | 1 out |
| » Major-league debuts: Chico Carrasquel (White Sox) Don Lenhardt (Browns) |
| Wednesday, April 19 |
| » Lost to Browns (2-0), 6-1 | Comiskey Park I (0-2) | 0-2 | Lost 2 |
| » Starters: Dick Starr vs Bob Kuzava | Seventh | 2 out |
| » Major-league debuts: Luis Aloma (White Sox) |
| Friday, April 21 |
| » Lost to Tigers (3-0), 4-1 | Tiger Stadium (0-1) | 0-3 | Lost 3 |
| » Starters: Mickey Haefner vs Virgil Trucks | Seventh | 3 out |
| Saturday, April 22 |
| » Lost to Tigers (4-0), 5-0 | Tiger Stadium (0-2) | 0-4 | Lost 4 |
| » Starters: Bill Wight vs Art Houtteman | Seventh | 4 out |
| Sunday, April 23 |
| » Defeated Tigers (4-1), 5-4 | Tiger Stadium (1-2) | 1-4 | |
| » Starters: Bob Kuzava vs Fred Hutchinson | Seventh | 3 out |
| » Major-league debuts: Jim Busby (White Sox) |
| Former White Sox Bill Hallman dies in Philadelphia, PA at the age of 75. |
| Sunday, April 30 |
| » Defeated Tigers (6-3), 5-0 | Comiskey Park I (1-2) | 2-4 | Won 2 |
| » Starters: Art Houtteman vs Bill Wight | Seventh | 2½ out |
| » Tied Tigers, 7-7 | Comiskey Park I (1-2) | 2-4 | |
| » Starters: Virgil Trucks vs Mickey Haefner | Seventh | 2½ out |
| Tuesday, May 2 |
| Former White Sox Jo Morrissey dies in Worcester, MA at the age of 47. |
| Wednesday, May 3 |
| » Lost to Yankees (7-4), 4-3 | Yankee Stadium (0-1) | 2-5 | |
| » Starters: Bob Kuzava vs Vic Raschi | Eighth | 3 out |
| Thursday, May 4 |
| » Defeated Yankees (7-5), 15-0 | Yankee Stadium (1-1) | 3-5 | |
| » Starters: Bob Cain vs Eddie Lopat | Seventh | 3 out |
| Friday, May 5 |
| » Lost to Red Sox (10-7), 5-2 | Fenway Park (0-1) | 3-6 | |
| » Starters: Billy Pierce vs Joe Dobson | Seventh | 4 out |
| Saturday, May 6 |
| » Lost to Red Sox (11-7), 11-1 | Fenway Park (0-2) | 3-7 | Lost 2 |
| » Starters: Ken Holcombe vs Chuck Stobbs | Eighth | 5 out |
| Sunday, May 7 |
| » Defeated Athletics (5-10), 7-3 | Shibe Park (1-0) | 4-7 | |
| » Starters: Bill Wight vs Lou Brissie | Seventh | 4½ out |
| » Lost to Athletics (6-10), 4-2 | Shibe Park (1-1) | 4-8 | |
| » Starters: Randy Gumpert vs Bob Hooper | Seventh | 4½ out |
| Monday, May 8 |
| Future White Sox Lloyd Allen is born in Merced, CA. |
| Tuesday, May 9 |
| » Lost to Senators (9-7), 3-2 | Griffith Stadium (0-1) | 4-9 | Lost 2 |
| » Starters: Mickey Haefner vs Lloyd Hittle | Seventh | 6 out |
| » Major-league debuts: Joe Erautt (White Sox) |
| Wednesday, May 10 |
| » Lost to Senators (10-7), 7-6 | Griffith Stadium (0-2) | 4-10 | Lost 3 |
| » Starters: Bob Kuzava vs Steve Nagy | Sixth | 6½ out |
| Thursday, May 11 |
| » Lost to Senators (11-7), 8-5 | Griffith Stadium (0-3) | 4-11 | Lost 4 |
| » Starters: Billy Pierce vs Joe Haynes | Seventh | 7 out |
| Friday, May 12 |
| » Lost to Indians (9-9), 5-1 | Cleveland Stadium (0-1) | 4-12 | Lost 5 |
| » Starters: Bill Wight vs Early Wynn | Seventh | 7½ out |
| Saturday, May 13 |
| » Lost to Indians (10-9), 6-2 | Cleveland Stadium (0-2) | 4-13 | Lost 6 |
| » Starters: Bob Cain vs Bob Feller | Seventh | 8½ out |
| Sunday, May 14 |
| » Defeated Indians (10-10), 3-2 | Cleveland Stadium (1-2) | 5-13 | |
| » Starters: Mickey Haefner vs Bob Lemon | Eighth | 8 out |
| » Lost to Indians (11-10), 3-1 | Cleveland Stadium (1-3) | 5-14 | |
| » Starters: Billy Pierce vs Mike Garcia | Eighth | 8 out |
| Tuesday, May 16 |
| » Lost to Senators (13-10), 6-5 | Comiskey Park I (1-3) | 5-15 | Lost 2 |
| » Starters: Joe Haynes vs Bill Wight | Eighth | 8½ out |
| Wednesday, May 17 |
| » Lost to Senators (14-10), 2-0 | Comiskey Park I (1-4) | 5-16 | Lost 3 |
| » Starters: Rae Scarborough vs Bob Kuzava | Eighth | 9½ out |
| Thursday, May 18 |
| » Lost to Senators (15-10), 7-3 | Comiskey Park I (1-5) | 5-17 | Lost 4 |
| » Starters: Sid Hudson vs Randy Gumpert | Eighth | 10 out |
| Friday, May 19 |
| » Lost to Yankees (17-8), 2-0 | Comiskey Park I (1-6) | 5-18 | Lost 5 |
| » Starters: Tommy Byrne vs Bob Cain | Eighth | 11 out |
| Saturday, May 20 |
| » Lost to Yankees (18-8), 3-1 | Comiskey Park I (1-7) | 5-19 | Lost 6 |
| » Starters: Fred Sanford vs Mickey Haefner | Seventh | 12 out |
| Sunday, May 21 |
| » Lost to Red Sox (20-13), 7-0 | Comiskey Park I (1-8) | 5-20 | Lost 7 |
| » Starters: Ellis Kinder vs Bill Wight | Eighth | 13 out |
| » Defeated Red Sox (20-14), 4-3 | Comiskey Park I (2-8) | 6-20 | |
| » Starters: Joe Dobson vs Billy Pierce | Eighth | 13 out |
| Future White Sox Bob Molinaro is born in Newark, NJ. |
| Monday, May 22 |
| » Defeated Red Sox (20-15), 10-9 | Comiskey Park I (3-8) | 7-20 | Won 2 |
| » Starters: Mickey McDermott vs Bob Kuzava | Eighth | 13 out |
| Wednesday, May 24 |
| » Defeated Athletics (10-21), 10-7 | Comiskey Park I (4-8) | 8-20 | Won 3 |
| » Starters: Dick Fowler vs Mickey Haefner | Eighth | 12½ out |
| Thursday, May 25 |
| » Lost to Athletics (11-21), 6-1 | Comiskey Park I (4-9) | 8-21 | |
| » Starters: Bobby Shantz vs Bill Wight | Seventh | 13½ out |
| Future White Sox Glenn Borgmann is born in Paterson, NJ. |
| Friday, May 26 |
| » Lost to Indians (18-14), 2-1 | Comiskey Park I (4-10) | 8-22 | Lost 2 |
| » Starters: Bob Feller vs Bob Cain | Eighth | 14½ out |
| Saturday, May 27 |
| » Defeated Indians (18-15), 6-1 | Comiskey Park I (5-10) | 9-22 | |
| » Manager: Red Corriden |
| » Starters: Mike Garcia vs Billy Pierce | Seventh | 13½ out |
| Sunday, May 28 |
| » Defeated Indians (18-16), 2-0 | Comiskey Park I (6-10) | 10-22 | Won 2 |
| » Starters: Early Wynn vs Bill Wight | Seventh | 13½ out |
| » Lost to Indians (19-16), 7-0 | Comiskey Park I (6-11) | 10-23 | |
| » Starters: Steve Gromek vs Mickey Haefner | Seventh | 13½ out |
| Monday, May 29 |
| » Defeated Browns (8-23), 12-8 | Sportsman's Park III (1-0) | 11-23 | |
| » Starters: Randy Gumpert vs Sid Schacht | Seventh | 13 out |
| Tuesday, May 30 |
| » Defeated Browns (8-24), 14-2 | Sportsman's Park III (2-0) | 12-23 | Won 2 |
| » Starters: Bob Kuzava vs Ned Garver | Seventh | 13 out |
| » Defeated Browns (8-25), 12-9 | Sportsman's Park III (3-0) | 13-23 | Won 3 |
| » Starters: Ken Holcombe vs Cliff Fannin | Seventh | 13 out |
| Thursday, June 1 |
| » Lost to Yankees (27-10), 6-5 | Yankee Stadium (1-2) | 13-24 | |
| » Starters: Billy Pierce vs Allie Reynolds | Seventh | 14 out |
| Friday, June 2 |
| » Defeated Yankees (27-11), 6-5 | Yankee Stadium (2-2) | 14-24 | |
| » Starters: Rae Scarborough vs Vic Raschi | Sixth | 13 out |
| Saturday, June 3 |
| » Lost to Yankees (28-11), 3-1 | Yankee Stadium (2-3) | 14-25 | |
| » Starters: Bob Cain vs Tommy Byrne | Sixth | 15 out |
| » Lost to Yankees (29-11), 6-3 | Yankee Stadium (2-4) | 14-26 | Lost 2 |
| » Starters: Bill Wight vs Fred Sanford | Sixth | 15 out |
| Sunday, June 4 |
| » Lost to Red Sox (27-18), 17-7 | Fenway Park (0-3) | 14-27 | Lost 3 |
| » Starters: Mickey Haefner vs Chuck Stobbs | Seventh | 16 out |
| Monday, June 5 |
| » Lost to Red Sox (28-18), 12-0 | Fenway Park (0-4) | 14-28 | Lost 4 |
| » Starters: Billy Pierce vs Ellis Kinder | Seventh | 16 out |
| Tuesday, June 6 |
| » Defeated Red Sox (28-19), 8-4 | Fenway Park (1-4) | 15-28 | |
| » Starters: Ken Holcombe vs Mel Parnell | Sixth | 14½ out |
| Wednesday, June 7 |
| » Lost to Athletics (16-29), 5-0 | Shibe Park (1-2) | 15-29 | |
| » Starters: Rae Scarborough vs Bobby Shantz | Seventh | 16 out |
| Thursday, June 8 |
| » Lost to Athletics (17-29), 5-4 | Shibe Park (1-3) | 15-30 | Lost 2 |
| » Starters: Bob Cain vs Alex Kellner | Seventh | 17 out |
| Friday, June 9 |
| » Defeated Athletics (17-30), 3-2 | Shibe Park (2-3) | 16-30 | |
| » Starters: Bill Wight vs Bob Hooper | Seventh | 16 out |
| Saturday, June 10 |
| » Lost to Senators (22-24), 6-0 | Griffith Stadium (0-4) | 16-31 | |
| » Starters: Billy Pierce vs Sandy Consuegra | Eighth | 15½ out |
| » Major-league debuts: Sandy Consuegra (Senators) |
| Sunday, June 11 |
| » Defeated Senators (22-25), 8-3 | Griffith Stadium (1-4) | 17-31 | |
| » Starters: Ken Holcombe vs Steve Nagy | Sixth | 15½ out |
| » Defeated Senators (22-26), 5-4 | Griffith Stadium (2-4) | 18-31 | Won 2 |
| » Starters: Rae Scarborough vs Lloyd Hittle | Sixth | 15½ out |
| Tuesday, June 13 |
| » Defeated Yankees (34-16), 6-5 | Comiskey Park I (7-11) | 19-31 | Won 3 |
| » Starters: Tommy Byrne vs Bob Cain | Sixth | 15½ out |
| Wednesday, June 14 |
| » Defeated Yankees (34-17), 5-2 | Comiskey Park I (8-11) | 20-31 | Won 4 |
| » Starters: Allie Reynolds vs Bill Wight | Sixth | 14½ out |
| Thursday, June 15 |
| » Defeated Yankees (34-18), 5-0 | Comiskey Park I (9-11) | 21-31 | Won 5 |
| » Starters: Eddie Lopat vs Billy Pierce | Sixth | 14½ out |
| Friday, June 16 |
| » Defeated Senators (23-30), 7-1 | Comiskey Park I (10-11) | 22-31 | Won 6 |
| » Starters: Steve Nagy vs Rae Scarborough | Sixth | 14½ out |
| Saturday, June 17 |
| » Lost to Senators (24-30), 6-3 | Comiskey Park I (10-12) | 22-32 | |
| » Starters: Bob Kuzava vs Ken Holcombe | Sixth | 15½ out |
| Monday, June 19 |
| » Defeated Senators (24-31), 4-3 | Comiskey Park I (11-12) | 23-32 | |
| » Starters: Sid Hudson vs Bob Cain | Sixth | 15½ out |
| Tuesday, June 20 |
| » Lost to Red Sox (32-28), 5-3 | Comiskey Park I (11-13) | 23-33 | |
| » Starters: Ellis Kinder vs Bill Wight | Sixth | 15½ out |
| Wednesday, June 21 |
| » Defeated Red Sox (32-29), 3-1 | Comiskey Park I (12-13) | 24-33 | |
| » Starters: Joe Dobson vs Billy Pierce | Sixth | 14½ out |
| Thursday, June 22 |
| » Defeated Red Sox (32-30), 4-2 | Comiskey Park I (13-13) | 25-33 | Won 2 |
| » Starters: Mel Parnell vs Rae Scarborough | Sixth | 13½ out |
| Friday, June 23 |
| » Defeated Athletics (21-40), 11-5 | Comiskey Park I (14-13) | 26-33 | Won 3 |
| » Starters: Alex Kellner vs Randy Gumpert | Sixth | 13½ out |
| Sunday, June 25 |
| » Defeated Athletics (21-41), 7-6 | Comiskey Park I (15-13) | 27-33 | Won 4 |
| » Starters: Lou Brissie vs Bill Wight | Sixth | 14 out |
| » Lost to Athletics (22-41), 13-4 | Comiskey Park I (15-14) | 27-34 | |
| » Starters: Bob Hooper vs Bob Cain | Sixth | 14 out |
| Monday, June 26 |
| » Lost to Tigers (41-19), 6-4 | Tiger Stadium (1-3) | 27-35 | Lost 2 |
| » Starters: Billy Pierce vs Hal White | Sixth | 15 out |
| Tuesday, June 27 |
| » Lost to Tigers (42-19), 9-3 | Tiger Stadium (1-4) | 27-36 | Lost 3 |
| » Starters: Rae Scarborough vs Ted Gray | Sixth | 16 out |
| Wednesday, June 28 |
| » Lost to Tigers (43-19), 6-2 | Tiger Stadium (1-5) | 27-37 | Lost 4 |
| » Starters: Ken Holcombe vs Art Houtteman | Sixth | 17 out |
| Former White Sox Mutz Ens dies in St.Louis, MO at the age of 66. |
| Thursday, June 29 |
| » Defeated Tigers (43-20), 7-3 | Tiger Stadium (2-5) | 28-37 | |
| » Starters: Bob Cain vs Fred Hutchinson | Sixth | 16 out |
| Friday, June 30 |
| » Defeated Browns (21-43), 3-2 | Comiskey Park I (16-14) | 29-37 | Won 2 |
| » Starters: Ned Garver vs Bill Wight | Sixth | 15 out |
| Saturday, July 1 |
| » Defeated Browns (21-44), 4-1 | Comiskey Park I (17-14) | 30-37 | Won 3 |
| » Starters: Stubby Overmire vs Billy Pierce | Sixth | 14 out |
| Sunday, July 2 |
| » Defeated Browns (21-45), 5-2 | Comiskey Park I (18-14) | 31-37 | Won 4 |
| » Starters: Fritz Dorish vs Rae Scarborough | Fifth | 14 out |
| » Lost to Browns (22-45), 4-3 | Comiskey Park I (18-15) | 31-38 | |
| » Starters: Al Widmar vs Randy Gumpert | Fifth | 14 out |
| Monday, July 3 |
| » Lost to Tigers (45-23), 8-4 | Comiskey Park I (18-16) | 31-39 | Lost 2 |
| » Starters: Fred Hutchinson vs Ken Holcombe | Sixth | 15 out |
| Tuesday, July 4 |
| » Defeated Tigers (45-24), 4-1 | Comiskey Park I (19-16) | 32-39 | |
| » Starters: Hal White vs Bill Wight | Sixth | 15 out |
| » Lost to Tigers (46-24), 10-9 | Comiskey Park I (19-17) | 32-40 | |
| » Starters: Hal Newhouser vs Bob Cain | Sixth | 15 out |
| Wednesday, July 5 |
| » Lost to Indians (43-30), 8-3 | Cleveland Stadium (1-4) | 32-41 | Lost 2 |
| » Starters: Billy Pierce vs Bob Lemon | Sixth | 16 out |
| Thursday, July 6 |
| » Lost to Indians (44-30), 5-2 | Cleveland Stadium (1-5) | 32-42 | Lost 3 |
| » Starters: Rae Scarborough vs Early Wynn | Sixth | 16½ out |
| Friday, July 7 |
| » Defeated Browns (24-48), 5-2 | Sportsman's Park III (4-0) | 33-42 | |
| » Starters: Bob Cain vs Fritz Dorish | Sixth | 17 out |
| » Lost to Browns (25-48), 4-3 | Sportsman's Park III (4-1) | 33-43 | |
| » Starters: Randy Gumpert vs Al Widmar | Sixth | 17 out |
| Saturday, July 8 |
| » Defeated Browns (25-49), 7-5 | Sportsman's Park III (5-1) | 34-43 | |
| » Starters: Ken Holcombe vs Stubby Overmire | Sixth | 17½ out |
| » Lost to Browns (26-49), 11-5 | Sportsman's Park III (5-2) | 34-44 | |
| » Starters: Mickey Haefner vs Duane Pillette | Sixth | 17½ out |
| Sunday, July 9 |
| » Lost to Browns (27-49), 4-2 | Sportsman's Park III (5-3) | 34-45 | Lost 2 |
| » Starters: Billy Pierce vs Ned Garver | Sixth | 17 out |
| Thursday, July 13 |
| » Lost to Red Sox (43-35), 8-7 | Fenway Park (1-5) | 34-46 | Lost 3 |
| » Starters: Rae Scarborough vs Willard Nixon | Sixth | 18 out |
| Friday, July 14 |
| » Lost to Red Sox (44-35), 13-1 | Fenway Park (1-6) | 34-47 | Lost 4 |
| » Starters: Ken Holcombe vs Ellis Kinder | Sixth | 19 out |
| Saturday, July 15 |
| » Defeated Red Sox (44-36), 7-3 | Fenway Park (2-6) | 35-47 | |
| » Starters: Lou Kretlow vs Dick Littlefield | Sixth | 18½ out |
| Sunday, July 16 |
| » Lost to Yankees (49-31), 2-1 | Yankee Stadium (2-5) | 35-48 | |
| » Starters: Billy Pierce vs Vic Raschi | Sixth | 18½ out |
| » Defeated Yankees (49-32), 5-2 | Yankee Stadium (3-5) | 36-48 | |
| » Starters: Bob Cain vs Allie Reynolds | Sixth | 18½ out |
| Monday, July 17 |
| » Lost to Yankees (50-32), 4-3 | Yankee Stadium (3-6) | 36-49 | |
| » Starters: Bill Wight vs Whitey Ford | Sixth | 20 out |
| Tuesday, July 18 |
| » Lost to Senators (38-44), 5-2 | Griffith Stadium (2-5) | 36-50 | Lost 2 |
| » Starters: Rae Scarborough vs Sandy Consuegra | Sixth | 20 out |
| Wednesday, July 19 |
| » Lost to Senators (39-44), 5-4 | Griffith Stadium (2-6) | 36-51 | Lost 3 |
| » Starters: Randy Gumpert vs Jim Pearce | Sixth | 21 out |
| Friday, July 21 |
| » Lost to Athletics (30-57), 7-6 | Shibe Park (2-4) | 36-52 | Lost 4 |
| » Starters: Bob Cain vs Lou Brissie | Sixth | 20½ out |
| Saturday, July 22 |
| » Defeated Athletics (30-58), 6-1 | Shibe Park (3-4) | 37-52 | |
| » Starters: Billy Pierce vs Bobby Shantz | Sixth | 19½ out |
| Sunday, July 23 |
| » Lost to Athletics (31-58), 2-1 | Shibe Park (3-5) | 37-53 | |
| » Starters: Bill Wight vs Hank Wyse | Sixth | 21 out |
| » Lost to Athletics (32-58), 5-4 | Shibe Park (3-6) | 37-54 | Lost 2 |
| » Starters: Rae Scarborough vs Bob Hooper | Sixth | 21 out |
| Tuesday, July 25 |
| » Lost to Senators (41-46), 7-4 | Comiskey Park I (19-18) | 37-55 | Lost 3 |
| » Starters: Jim Pearce vs Bob Cain | Sixth | 21 out |
| Thursday, July 27 |
| » Lost to Senators (42-46), 3-2 | Comiskey Park I (19-19) | 37-56 | Lost 4 |
| » Starters: Sid Hudson vs Billy Pierce | Sixth | 21 out |
| » Defeated Senators (42-47), 6-3 | Comiskey Park I (20-19) | 38-56 | |
| » Starters: Connie Marrero vs Randy Gumpert | Sixth | 21 out |
| Friday, July 28 |
| » Lost to Yankees (57-35), 4-1 | Comiskey Park I (20-20) | 38-57 | |
| » Starters: Allie Reynolds vs Bill Wight | Sixth | 21 out |
| Saturday, July 29 |
| » Lost to Yankees (58-35), 11-4 | Comiskey Park I (20-21) | 38-58 | Lost 2 |
| » Starters: Eddie Lopat vs Rae Scarborough | Sixth | 22 out |
| Sunday, July 30 |
| » Lost to Yankees (59-35), 15-7 | Comiskey Park I (20-22) | 38-59 | Lost 3 |
| » Starters: Vic Raschi vs Bob Cain | Sixth | 23½ out |
| » Lost to Yankees (60-35), 4-3 | Comiskey Park I (20-23) | 38-60 | Lost 4 |
| » Starters: Whitey Ford vs Ken Holcombe | Sixth | 23½ out |
| Tuesday, August 1 |
| » Defeated Athletics (34-63), 8-1 | Comiskey Park I (21-23) | 39-60 | |
| » Starters: Moe Burtschy vs Billy Pierce | Sixth | 23½ out |
| Future White Sox Milt May is born in Gary, IN. |
| Wednesday, August 2 |
| » Lost to Athletics (35-63), 10-3 | Comiskey Park I (21-24) | 39-61 | |
| » Starters: Carl Scheib vs Rae Scarborough | Sixth | 24½ out |
| Thursday, August 3 |
| » Defeated Athletics (35-64), 1-0 | Comiskey Park I (22-24) | 40-61 | |
| » Starters: Hank Wyse vs Randy Gumpert | Sixth | 24½ out |
| Friday, August 4 |
| » Defeated Red Sox (56-44), 3-2 | Comiskey Park I (23-24) | 41-61 | Won 2 |
| » Starters: Willard Nixon vs Ken Holcombe | Sixth | 23½ out |
| Saturday, August 5 |
| » Lost to Red Sox (57-44), 12-7 | Comiskey Park I (23-25) | 41-62 | |
| » Starters: Walt Masterson vs Bob Cain | Sixth | 24½ out |
| Sunday, August 6 |
| » Lost to Red Sox (58-44), 9-2 | Comiskey Park I (23-26) | 41-63 | Lost 2 |
| » Starters: Ellis Kinder vs Billy Pierce | Sixth | 26 out |
| » Lost to Red Sox (59-44), 4-3 | Comiskey Park I (23-27) | 41-64 | Lost 3 |
| » Starters: Joe Dobson vs Howie Judson | Sixth | 26 out |
| Tuesday, August 8 |
| » Defeated Tigers (64-36), 9-6 | Comiskey Park I (24-27) | 42-64 | |
| » Starters: Hal White vs Bill Wight | Fifth | 25 out |
| Wednesday, August 9 |
| » Lost to Tigers (65-36), 5-3 | Comiskey Park I (24-28) | 42-65 | |
| » Starters: Fred Hutchinson vs Rae Scarborough | Sixth | 26 out |
| Former White Sox Ed Klepfer dies in Tulsa, OK at the age of 63. |
| Thursday, August 10 |
| » Lost to Tigers (66-36), 10-6 | Comiskey Park I (24-29) | 42-66 | Lost 2 |
| » Starters: Art Houtteman vs Ken Holcombe | Sixth | 27 out |
| » Tied Tigers, 1-1 | Comiskey Park I (24-29) | 42-66 | |
| » Starters: Hal Newhouser vs Randy Gumpert | Sixth | 27 out |
| Friday, August 11 |
| » Lost to Indians (65-41), 3-2 | Comiskey Park I (24-30) | 42-67 | Lost 3 |
| » Starters: Mike Garcia vs Billy Pierce | Sixth | 27½ out |
| Saturday, August 12 |
| » Defeated Indians (65-42), 11-4 | Comiskey Park I (25-30) | 43-67 | |
| » Starters: Steve Gromek vs Howie Judson | Sixth | 27 out |
| Sunday, August 13 |
| » Lost to Indians (66-42), 5-2 | Comiskey Park I (25-31) | 43-68 | |
| » Starters: Bob Feller vs Bill Wight | Sixth | 27 out |
| » Defeated Indians (66-43), 7-5 | Comiskey Park I (26-31) | 44-68 | |
| » Starters: Dick Weik vs Rae Scarborough | Sixth | 27 out |
| Wednesday, August 16 |
| » Lost to Tigers (69-38), 6-2 | Tiger Stadium (2-6) | 44-69 | |
| » Starters: Billy Pierce vs Dizzy Trout | Sixth | 28 out |
| Thursday, August 17 |
| » Lost to Tigers (70-38), 8-3 | Tiger Stadium (2-7) | 44-70 | Lost 2 |
| » Starters: Randy Gumpert vs Hal White | Sixth | 29 out |
| Future White Sox Larry Johnson is born in Cleveland, OH. |
| Saturday, August 19 |
| » Lost to Indians (71-44), 1-0 | Cleveland Stadium (1-6) | 44-71 | Lost 3 |
| » Starters: Ken Holcombe vs Early Wynn | Sixth | 30 out |
| Sunday, August 20 |
| » Defeated Indians (71-45), 2-1 | Cleveland Stadium (2-6) | 45-71 | |
| » Starters: Bill Wight vs Bob Lemon | Sixth | 29 out |
| » Defeated Indians (71-46), 6-5 | Cleveland Stadium (3-6) | 46-71 | Won 2 |
| » Starters: Billy Pierce vs Mike Garcia | Sixth | 29 out |
| » Major-league debuts: Jim Lemon (Indians) |
| Wednesday, August 23 |
| » Defeated Athletics (40-78), 1-0 | Shibe Park (4-6) | 47-71 | Won 3 |
| » Starters: Rae Scarborough vs Lou Brissie | Sixth | 28½ out |
| » Lost to Athletics (41-78), 6-5 | Shibe Park (4-7) | 47-72 | |
| » Starters: Randy Gumpert vs Hank Wyse | Sixth | 28½ out |
| Friday, August 25 |
| » Defeated Senators (50-65), 6-1 | Griffith Stadium (3-6) | 48-72 | |
| » Starters: Ken Holcombe vs Al Sima | Sixth | 27½ out |
| » Defeated Senators (50-66), 10-5 | Griffith Stadium (4-6) | 49-72 | Won 2 |
| » Starters: Billy Pierce vs Connie Marrero | Sixth | 27½ out |
| Future White Sox Stan Perzanowski is born in East Chicago, IN. |
| Saturday, August 26 |
| » Lost to Senators (51-66), 7-6 | Griffith Stadium (4-7) | 49-73 | |
| » Starters: Bill Wight vs Gene Bearden | Sixth | 28½ out |
| Sunday, August 27 |
| » Lost to Yankees (76-45), 2-1 | Yankee Stadium (3-7) | 49-74 | Lost 2 |
| » Starters: Bob Cain vs Allie Reynolds | Sixth | 29 out |
| Monday, August 28 |
| » Defeated Yankees (76-46), 6-4 | Yankee Stadium (4-7) | 50-74 | |
| » Starters: Rae Scarborough vs Fred Sanford | Sixth | 28 out |
| Tuesday, August 29 |
| » Lost to Red Sox (76-49), 13-6 | Fenway Park (2-7) | 50-75 | |
| » Starters: Randy Gumpert vs Mel Parnell | Fifth | 28 out |
| Wednesday, August 30 |
| » Lost to Red Sox (77-49), 6-1 | Fenway Park (2-8) | 50-76 | Lost 2 |
| » Starters: Ken Holcombe vs Joe Dobson | Sixth | 29½ out |
| Thursday, August 31 |
| » Lost to Red Sox (78-49), 4-3 | Fenway Park (2-9) | 50-77 | Lost 3 |
| » Starters: Billy Pierce vs Walt Masterson | Sixth | 30½ out |
| » Major-league debuts: Fred Hatfield (Red Sox) |
| Saturday, September 2 |
| » Lost to Tigers (78-47), 8-2 | Tiger Stadium (2-8) | 50-78 | Lost 4 |
| » Starters: Rae Scarborough vs Hal Newhouser | Sixth | 32 out |
| Future White Sox Lamar Johnson is born in Bessemer, AL. |
| Sunday, September 3 |
| » Lost to Tigers (79-47), 4-2 | Tiger Stadium (2-9) | 50-79 | Lost 5 |
| » Starters: Bill Wight vs Fred Hutchinson | Sixth | 32½ out |
| Monday, September 4 |
| » Defeated Indians (78-53), 7-1 | Comiskey Park I (27-31) | 51-79 | |
| » Starters: Bob Lemon vs Bob Cain | Sixth | 32½ out |
| » Lost to Indians (79-53), 1-0 | Comiskey Park I (27-32) | 51-80 | |
| » Starters: Mike Garcia vs Randy Gumpert | Sixth | 32½ out |
| Tuesday, September 5 |
| » Lost to Indians (80-53), 3-2 | Comiskey Park I (27-33) | 51-81 | Lost 2 |
| » Starters: Steve Gromek vs Billy Pierce | Sixth | 33 out |
| Wednesday, September 6 |
| » Defeated Browns (44-86), 6-5 | Comiskey Park I (28-33) | 52-81 | |
| » Starters: Cliff Fannin vs Rae Scarborough | Sixth | 32 out |
| Thursday, September 7 |
| » Lost to Browns (45-86), 6-0 | Comiskey Park I (28-34) | 52-82 | |
| » Starters: Dick Starr vs Howie Judson | Sixth | 32 out |
| Friday, September 8 |
| » Lost to Tigers (83-48), 3-2 | Comiskey Park I (28-35) | 52-83 | Lost 2 |
| » Starters: Dizzy Trout vs Bob Cain | Sixth | 33 out |
| Saturday, September 9 |
| » Lost to Tigers (84-48), 7-0 | Comiskey Park I (28-36) | 52-84 | Lost 3 |
| » Starters: Art Houtteman vs Billy Pierce | Sixth | 34 out |
| Sunday, September 10 |
| » Lost to Tigers (85-48), 1-0 | Comiskey Park I (28-37) | 52-85 | Lost 4 |
| » Starters: Hal Newhouser vs Randy Gumpert | Sixth | 34 out |
| » Defeated Tigers (85-49), 5-4 | Comiskey Park I (29-37) | 53-85 | |
| » Starters: Ray Herbert vs Rae Scarborough | Sixth | 34 out |
| Tuesday, September 12 |
| » Lost to Red Sox (86-51), 2-1 | Comiskey Park I (29-38) | 53-86 | |
| » Starters: Mel Parnell vs Bill Wight | Sixth | 35 out |
| Thursday, September 14 |
| » Defeated Athletics (47-94), 5-2 | Comiskey Park I (30-38) | 54-86 | |
| » Starters: Bobby Shantz vs Bob Cain | Sixth | 35 out |
| Friday, September 15 |
| » Lost to Athletics (48-94), 4-1 | Comiskey Park I (30-39) | 54-87 | |
| » Starters: Hank Wyse vs Rae Scarborough | Sixth | 35½ out |
| Saturday, September 16 |
| » Defeated Athletics (48-95), 10-3 | Comiskey Park I (31-39) | 55-87 | |
| » Starters: Alex Kellner vs Billy Pierce | Sixth | 35 out |
| Sunday, September 17 |
| » Defeated Senators (60-80), 4-0 | Comiskey Park I (32-39) | 56-87 | Won 2 |
| » Starters: Connie Marrero vs Bill Wight | Sixth | 35 out |
| » Lost to Senators (61-80), 3-2 | Comiskey Park I (32-40) | 56-88 | |
| » Starters: Bob Kuzava vs Randy Gumpert | Sixth | 35 out |
| Tuesday, September 19 |
| » Defeated Yankees (90-53), 4-3 | Comiskey Park I (33-40) | 57-88 | |
| » Starters: Vic Raschi vs Bob Cain | Fifth | 34 out |
| Wednesday, September 20 |
| » Lost to Yankees (91-53), 8-1 | Comiskey Park I (33-41) | 57-89 | |
| » Starters: Whitey Ford vs Rae Scarborough | Sixth | 35 out |
| » Major-league debuts: Ed McGhee (White Sox) |
| Saturday, September 23 |
| » Defeated Browns (54-91), 12-5 | Sportsman's Park III (6-3) | 58-89 | |
| » Starters: Billy Pierce vs Al Widmar | Sixth | 35 out |
| Sunday, September 24 |
| » Lost to Browns (55-91), 5-0 | Sportsman's Park III (6-4) | 58-90 | |
| » Starters: Randy Gumpert vs Stubby Overmire | Sixth | 36½ out |
| » Lost to Browns (56-91), 6-1 | Sportsman's Park III (6-5) | 58-91 | Lost 2 |
| » Starters: Bill Wight vs Ned Garver | Sixth | 36½ out |
| » Major-league debuts: Bill Wilson (White Sox) |
| Tuesday, September 26 |
| » Lost to Indians (89-61), 2-0 | Cleveland Stadium (3-7) | 58-92 | Lost 3 |
| » Starters: Bob Cain vs Early Wynn | Sixth | 38 out |
| Wednesday, September 27 |
| » Lost to Indians (90-61), 7-0 | Cleveland Stadium (3-8) | 58-93 | Lost 4 |
| » Starters: Rae Scarborough vs Bob Feller | Sixth | 38 out |
| Saturday, September 30 |
| » Defeated Browns (57-95), 8-2 | Comiskey Park I (34-41) | 59-93 | |
| » Starters: Al Widmar vs Billy Pierce | Sixth | 38½ out |
| Sunday, October 1 |
| » Defeated Browns (57-96), 4-3 | Comiskey Park I (35-41) | 60-93 | Won 2 |
| » Starters: Ned Garver vs Bill Wight | Sixth | 38 out |
| » Lost to Browns (58-96), 10-6 | Comiskey Park I (35-42) | 60-94 | |
| » Starters: Stubby Overmire vs Gus Keriazakos | Sixth | 38 out |
| Monday, October 9 |
| Future White Sox Brian Downing is born in Los Angeles, CA. |
| Thursday, November 16 |
| Former White Sox Frank Hemphill dies in Chicago, IL at the age of 73. |
| Wednesday, November 22 |
| Future White Sox Greg Luzinski is born in Chicago, IL. |
| Sunday, November 26 |
| Future White Sox Jorge Orta is born in Mazatlan, Mexico. |
| Thursday, December 7 |
| Future White Sox Rich Coggins is born in Indianapolis, IN. |
| Friday, December 15 |
| Future White Sox Mike Proly is born in Jamaica, NY. |
Game information provided by Retrosheet (www.retrosheet.org) |