| Saturday, January 7 |
| Future Indian Ross Grimsley is born in Topeka, KS. |
| Thursday, January 26 |
| Former Indian Chick Autry dies in Savannah, GA at the age of 47. |
| Saturday, January 28 |
| Future Indian Larvell Blanks is born in Del Rio, TX. |
| Sunday, February 26 |
| Future Indian Jack Brohamer is born in Maywood, CA. |
| Tuesday, April 18 |
| » Lost to Tigers (1-0), 7-6 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Fred Hutchinson vs Bob Lemon | Second | 1 out |
| Wednesday, April 19 |
| » Major-league debuts: Luis Aloma (White Sox) |
| Thursday, April 20 |
| » Lost to Tigers (2-0), 5-4 | Cleveland Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Ted Gray vs Early Wynn | Fifth | 2 out |
| Future Indian Milt Wilcox is born in Honolulu, HI. |
| Saturday, April 22 |
| » Defeated Browns (2-1), 6-2 | Sportsman's Park III (1-0) | 1-2 | |
| » Starters: Bob Feller vs Stubby Overmire | Sixth | 2½ out |
| Sunday, April 23 |
| » Defeated Browns (2-2), 9-6 | Sportsman's Park III (2-0) | 2-2 | Won 2 |
| » Starters: Bob Lemon vs Ed Albrecht | Second | 1 out |
| » Defeated Browns (2-3), 7-5 | Sportsman's Park III (3-0) | 3-2 | Won 3 |
| » Starters: Sam Zoldak vs Ned Garver | Second | 1 out |
| » Major-league debuts: Sid Schacht (Browns) |
| Tuesday, April 25 |
| » Major-league debuts: Lou Sleater (Browns) |
| Friday, April 28 |
| » Defeated Tigers (6-2), 6-1 | Tiger Stadium (1-0) | 4-2 | Won 4 |
| » Starters: Bob Feller vs Ted Gray | Second | 1 out |
| Saturday, April 29 |
| » Lost to Browns (3-5), 5-1 | Cleveland Stadium (0-3) | 4-3 | |
| » Starters: Joe Ostrowski vs Bob Lemon | Third | 1½ out |
| » Major-league debuts: Dick Rozek (Indians) |
| Tuesday, May 2 |
| » Lost to Red Sox (8-6), 6-1 | Fenway Park (0-1) | 4-4 | Lost 2 |
| » Starters: Mike Garcia vs Mickey McDermott | Fifth | 1½ out |
| Wednesday, May 3 |
| » Lost to Red Sox (9-6), 7-2 | Fenway Park (0-2) | 4-5 | Lost 3 |
| » Starters: Bob Feller vs Ellis Kinder | Fifth | 2 out |
| Thursday, May 4 |
| » Defeated Red Sox (9-7), 5-4 | Fenway Park (1-2) | 5-5 | |
| » Starters: Bob Lemon vs Mel Parnell | Fifth | 2 out |
| Saturday, May 6 |
| » Defeated Yankees (7-6), 5-4 | Yankee Stadium (1-0) | 6-5 | Won 2 |
| » Starters: Early Wynn vs Allie Reynolds | Fourth | 3 out |
| » Lost to Yankees (8-6), 7-4 | Yankee Stadium (1-1) | 6-6 | |
| » Starters: Sam Zoldak vs Fred Sanford | Fourth | 3 out |
| Sunday, May 7 |
| » Lost to Senators (7-7), 10-5 | Griffith Stadium (0-1) | 6-7 | Lost 2 |
| » Starters: Mike Garcia vs Connie Marrero | Fifth | 3 out |
| Monday, May 8 |
| » Lost to Senators (8-7), 4-2 | Griffith Stadium (0-2) | 6-8 | Lost 3 |
| » Starters: Bob Feller vs Sid Hudson | Fifth | 4 out |
| Tuesday, May 9 |
| » Lost to Athletics (7-10), 9-8 | Shibe Park (0-1) | 6-9 | Lost 4 |
| » Starters: Steve Gromek vs Hank Wyse | Sixth | 5 out |
| Wednesday, May 10 |
| » Defeated Athletics (7-11), 6-4 | Shibe Park (1-1) | 7-9 | |
| » Starters: Bob Lemon vs Bobby Shantz | Fourth | 4½ out |
| Thursday, May 11 |
| » Defeated Athletics (7-12), 4-3 | Shibe Park (2-1) | 8-9 | Won 2 |
| » Starters: Mike Garcia vs Alex Kellner | Fifth | 4 out |
| Friday, May 12 |
| » Defeated White Sox (4-12), 5-1 | Cleveland Stadium (1-3) | 9-9 | Won 3 |
| » Starters: Bill Wight vs Early Wynn | Fifth | 3½ out |
| Saturday, May 13 |
| » Defeated White Sox (4-13), 6-2 | Cleveland Stadium (2-3) | 10-9 | Won 4 |
| » Starters: Bob Cain vs Bob Feller | Fifth | 3½ out |
| Sunday, May 14 |
| » Lost to White Sox (5-13), 3-2 | Cleveland Stadium (2-4) | 10-10 | |
| » Starters: Mickey Haefner vs Bob Lemon | Fifth | 3 out |
| » Defeated White Sox (5-14), 3-1 | Cleveland Stadium (3-4) | 11-10 | |
| » Starters: Billy Pierce vs Mike Garcia | Fifth | 3 out |
| Tuesday, May 16 |
| » Defeated Athletics (8-15), 15-4 | Cleveland Stadium (4-4) | 12-10 | Won 2 |
| » Starters: Alex Kellner vs Early Wynn | Fifth | 2½ out |
| Wednesday, May 17 |
| » Lost to Athletics (9-15), 7-5 | Cleveland Stadium (4-5) | 12-11 | |
| » Starters: Dick Fowler vs Bob Feller | Fifth | 3½ out |
| Thursday, May 18 |
| » Defeated Athletics (9-16), 4-3 | Cleveland Stadium (5-5) | 13-11 | |
| » Starters: Lou Brissie vs Steve Gromek | Fifth | 3 out |
| Friday, May 19 |
| » Defeated Red Sox (19-12), 4-1 | Cleveland Stadium (6-5) | 14-11 | Won 2 |
| » Starters: Mel Parnell vs Mike Garcia | Fifth | 3 out |
| Saturday, May 20 |
| » Defeated Red Sox (19-13), 8-5 | Cleveland Stadium (7-5) | 15-11 | Won 3 |
| » Starters: Chuck Stobbs vs Bob Lemon | Fourth | 3 out |
| » Major-league debuts: Jim Suchecki (Red Sox) |
| Sunday, May 21 |
| » Lost to Yankees (19-8), 14-5 | Cleveland Stadium (7-6) | 15-12 | |
| » Starters: Eddie Lopat vs Early Wynn | Fifth | 5 out |
| » Lost to Yankees (20-8), 12-4 | Cleveland Stadium (7-7) | 15-13 | Lost 2 |
| » Starters: Allie Reynolds vs Bob Feller | Fifth | 5 out |
| Monday, May 22 |
| » Lost to Yankees (21-8), 7-2 | Cleveland Stadium (7-8) | 15-14 | Lost 3 |
| » Starters: Vic Raschi vs Mike Garcia | Fifth | 6 out |
| Wednesday, May 24 |
| » Defeated Senators (17-13), 5-4 | Cleveland Stadium (8-8) | 16-14 | |
| » Starters: Steve Nagy vs Early Wynn | Fifth | 5½ out |
| Thursday, May 25 |
| » Defeated Senators (17-14), 3-0 | Cleveland Stadium (9-8) | 17-14 | Won 2 |
| » Starters: Dick Weik vs Bob Lemon | Fourth | 5½ out |
| Friday, May 26 |
| » Defeated White Sox (8-22), 2-1 | Comiskey Park I (1-0) | 18-14 | Won 3 |
| » Starters: Bob Feller vs Bob Cain | Fourth | 5½ out |
| Saturday, May 27 |
| » Lost to White Sox (9-22), 6-1 | Comiskey Park I (1-1) | 18-15 | |
| » Starters: Mike Garcia vs Billy Pierce | Fourth | 5½ out |
| Sunday, May 28 |
| » Lost to White Sox (10-22), 2-0 | Comiskey Park I (1-2) | 18-16 | Lost 2 |
| » Starters: Early Wynn vs Bill Wight | Fourth | 5½ out |
| » Defeated White Sox (10-23), 7-0 | Comiskey Park I (2-2) | 19-16 | |
| » Starters: Steve Gromek vs Mickey Haefner | Fourth | 5½ out |
| Tuesday, May 30 |
| » Defeated Tigers (21-12), 4-0 | Tiger Stadium (2-0) | 20-16 | Won 2 |
| » Starters: Bob Lemon vs Art Houtteman | Fourth | 6½ out |
| » Lost to Tigers (22-12), 5-2 | Tiger Stadium (2-1) | 20-17 | |
| » Starters: Gene Bearden vs Hal Newhouser | Fourth | 6½ out |
| Friday, June 2 |
| » Lost to Red Sox (25-18), 11-5 | Fenway Park (1-3) | 20-18 | Lost 2 |
| » Starters: Bob Feller vs Joe Dobson | Fourth | 7 out |
| Saturday, June 3 |
| » Lost to Red Sox (26-18), 11-9 | Fenway Park (1-4) | 20-19 | Lost 3 |
| » Starters: Mike Garcia vs Mel Parnell | Fourth | 8½ out |
| Sunday, June 4 |
| » Lost to Yankees (30-11), 7-0 | Yankee Stadium (1-2) | 20-20 | Lost 4 |
| » Starters: Bob Lemon vs Eddie Lopat | Fourth | 9½ out |
| Monday, June 5 |
| » Defeated Yankees (30-12), 3-2 | Yankee Stadium (2-2) | 21-20 | |
| » Starters: Bob Feller vs Allie Reynolds | Fourth | 8½ out |
| Tuesday, June 6 |
| » Defeated Yankees (30-13), 16-2 | Yankee Stadium (3-2) | 22-20 | Won 2 |
| » Starters: Mike Garcia vs Bob Porterfield | Fourth | 7 out |
| Wednesday, June 7 |
| » Lost to Senators (20-23), 5-4 | Griffith Stadium (0-3) | 22-21 | |
| » Starters: Early Wynn vs Sid Hudson | Fourth | 8½ out |
| Thursday, June 8 |
| » Lost to Senators (21-23), 7-6 | Griffith Stadium (0-4) | 22-22 | Lost 2 |
| » Starters: Bob Lemon vs Bob Kuzava | Fourth | 9½ out |
| Friday, June 9 |
| » Defeated Senators (21-24), 8-7 | Griffith Stadium (1-4) | 23-22 | |
| » Starters: Bob Feller vs Connie Marrero | Fourth | 8½ out |
| Saturday, June 10 |
| » Defeated Athletics (17-31), 7-3 | Shibe Park (3-1) | 24-22 | Won 2 |
| » Starters: Mike Garcia vs Lou Brissie | Fourth | 7 out |
| Sunday, June 11 |
| » Defeated Athletics (17-32), 6-3 | Shibe Park (4-1) | 25-22 | Won 3 |
| » Starters: Bob Lemon vs Bobby Shantz | Fourth | 8 out |
| » Lost to Athletics (18-32), 9-6 | Shibe Park (4-2) | 25-23 | |
| » Starters: Steve Gromek vs Alex Kellner | Fourth | 8 out |
| Tuesday, June 13 |
| » Lost to Red Sox (31-23), 8-1 | Cleveland Stadium (9-9) | 25-24 | Lost 2 |
| » Starters: Chuck Stobbs vs Bob Feller | Fourth | 9 out |
| Wednesday, June 14 |
| » Defeated Red Sox (31-24), 7-3 | Cleveland Stadium (10-9) | 26-24 | |
| » Starters: Ellis Kinder vs Mike Garcia | Fourth | 8 out |
| Thursday, June 15 |
| » Defeated Red Sox (31-25), 3-1 | Cleveland Stadium (11-9) | 27-24 | Won 2 |
| » Starters: Walt Masterson vs Bob Lemon | Fourth | 8 out |
| Friday, June 16 |
| » Defeated Athletics (19-35), 3-2 | Cleveland Stadium (12-9) | 28-24 | Won 3 |
| » Starters: Alex Kellner vs Early Wynn | Fourth | 8 out |
| Saturday, June 17 |
| » Defeated Athletics (19-36), 8-7 | Cleveland Stadium (13-9) | 29-24 | Won 4 |
| » Starters: Bob Hooper vs Gene Bearden | Third | 8 out |
| Sunday, June 18 |
| » Defeated Athletics (19-37), 7-0 | Cleveland Stadium (14-9) | 30-24 | Won 5 |
| » Starters: Dick Fowler vs Bob Feller | Third | 7½ out |
| » Defeated Athletics (19-38), 21-2 | Cleveland Stadium (15-9) | 31-24 | Won 6 |
| » Starters: Lou Brissie vs Mike Garcia | Third | 7½ out |
| Monday, June 19 |
| Future Indian Duane Kuiper is born in Racine, WI. |
| Tuesday, June 20 |
| » Lost to Yankees (38-19), 8-2 | Cleveland Stadium (15-10) | 31-25 | |
| » Starters: Eddie Lopat vs Bob Lemon | Third | 7½ out |
| Wednesday, June 21 |
| » Defeated Yankees (38-20), 5-1 | Cleveland Stadium (16-10) | 32-25 | |
| » Starters: Vic Raschi vs Early Wynn | Third | 6½ out |
| Thursday, June 22 |
| » Defeated Yankees (38-21), 6-2 | Cleveland Stadium (17-10) | 33-25 | Won 2 |
| » Starters: Joe Ostrowski vs Bob Feller | Third | 5½ out |
| Friday, June 23 |
| » Defeated Senators (27-32), 13-4 | Cleveland Stadium (18-10) | 34-25 | Won 3 |
| » Starters: Bob Ross vs Bob Lemon | Third | 5½ out |
| Saturday, June 24 |
| » Defeated Senators (27-33), 6-5 | Cleveland Stadium (19-10) | 35-25 | Won 4 |
| » Starters: Sid Hudson vs Gene Bearden | Third | 5½ out |
| Sunday, June 25 |
| » Defeated Senators (27-34), 7-6 | Cleveland Stadium (20-10) | 36-25 | Won 5 |
| » Starters: Connie Marrero vs Early Wynn | Third | 5½ out |
| » Lost to Senators (28-34), 5-3 | Cleveland Stadium (20-11) | 36-26 | |
| » Starters: Sandy Consuegra vs Dick Weik | Third | 5½ out |
| Monday, June 26 |
| Future Indian Dave Rosello is born in Mayaguez, P.R. |
| Tuesday, June 27 |
| » Lost to Browns (21-40), 4-3 | Sportsman's Park III (3-1) | 36-27 | Lost 2 |
| » Starters: Bob Feller vs Al Widmar | Third | 7 out |
| Wednesday, June 28 |
| » Defeated Browns (21-41), 18-2 | Sportsman's Park III (4-1) | 37-27 | |
| » Starters: Bob Lemon vs Fritz Dorish | Third | 7 out |
| Thursday, June 29 |
| » Defeated Browns (21-42), 4-1 | Sportsman's Park III (5-1) | 38-27 | Won 2 |
| » Starters: Steve Gromek vs Duane Pillette | Third | 6 out |
| Friday, June 30 |
| » Defeated Tigers (43-21), 11-3 | Cleveland Stadium (21-11) | 39-27 | Won 3 |
| » Starters: Hal Newhouser vs Mike Garcia | Third | 5 out |
| Saturday, July 1 |
| » Defeated Tigers (43-22), 7-4 | Cleveland Stadium (22-11) | 40-27 | Won 4 |
| » Starters: Hal White vs Early Wynn | Second | 4 out |
| Sunday, July 2 |
| » Lost to Tigers (44-22), 8-5 | Cleveland Stadium (22-12) | 40-28 | |
| » Starters: Art Houtteman vs Bob Lemon | Third | 4 out |
| » Defeated Tigers (44-23), 5-3 | Cleveland Stadium (23-12) | 41-28 | |
| » Starters: Ted Gray vs Bob Feller | Third | 4 out |
| Monday, July 3 |
| » Lost to Browns (23-45), 4-2 | Cleveland Stadium (23-13) | 41-29 | |
| » Starters: Dick Starr vs Steve Gromek | Third | 5 out |
| Tuesday, July 4 |
| » Defeated Browns (23-46), 8-7 | Cleveland Stadium (24-13) | 42-29 | |
| » Starters: Duane Pillette vs Dick Rozek | Third | 5 out |
| » Lost to Browns (24-46), 8-3 | Cleveland Stadium (24-14) | 42-30 | |
| » Starters: Don Johnson vs Mike Garcia | Third | 5 out |
| Wednesday, July 5 |
| » Defeated White Sox (32-41), 8-3 | Cleveland Stadium (25-14) | 43-30 | |
| » Starters: Billy Pierce vs Bob Lemon | Third | 5 out |
| Thursday, July 6 |
| » Defeated White Sox (32-42), 5-2 | Cleveland Stadium (26-14) | 44-30 | Won 2 |
| » Starters: Rae Scarborough vs Early Wynn | Third | 4½ out |
| Friday, July 7 |
| » Lost to Tigers (48-24), 5-2 | Tiger Stadium (2-2) | 44-31 | |
| » Starters: Bob Feller vs Ted Gray | Third | 5½ out |
| Saturday, July 8 |
| » Lost to Tigers (49-24), 5-4 | Tiger Stadium (2-3) | 44-32 | Lost 2 |
| » Starters: Steve Gromek vs Hal Newhouser | Third | 6½ out |
| Sunday, July 9 |
| » Defeated Tigers (49-25), 6-2 | Tiger Stadium (3-3) | 45-32 | |
| » Starters: Bob Lemon vs Art Houtteman | Third | 4½ out |
| » Defeated Tigers (49-26), 5-2 | Tiger Stadium (4-3) | 46-32 | Won 2 |
| » Starters: Mike Garcia vs Saul Rogovin | Third | 4½ out |
| Friday, July 14 |
| » Defeated Yankees (47-31), 5-1 | Yankee Stadium (4-2) | 47-32 | Won 3 |
| » Starters: Bob Lemon vs Tommy Byrne | Third | 5 out |
| Saturday, July 15 |
| » Lost to Yankees (48-31), 4-3 | Yankee Stadium (4-3) | 47-33 | |
| » Starters: Bob Feller vs Eddie Lopat | Third | 5½ out |
| Sunday, July 16 |
| » Lost to Red Sox (45-36), 13-10 | Fenway Park (1-5) | 47-34 | Lost 2 |
| » Starters: Mike Garcia vs Mel Parnell | Third | 5½ out |
| » Defeated Red Sox (45-37), 8-4 | Fenway Park (2-5) | 48-34 | |
| » Starters: Steve Gromek vs Walt Masterson | Third | 5½ out |
| Former Indian Fred Blanding dies in Salem, VA at the age of 65. |
| Monday, July 17 |
| » Defeated Red Sox (45-38), 11-6 | Fenway Park (3-5) | 49-34 | Won 2 |
| » Starters: Early Wynn vs Joe Dobson | Third | 6½ out |
| » Lost to Red Sox (46-38), 7-5 | Fenway Park (3-6) | 49-35 | |
| » Starters: Mike Garcia vs Mickey McDermott | Third | 6½ out |
| Tuesday, July 18 |
| » Defeated Athletics (29-55), 10-2 | Shibe Park (5-2) | 50-35 | |
| » Starters: Bob Lemon vs Bobby Shantz | Third | 5½ out |
| Wednesday, July 19 |
| » Defeated Athletics (29-56), 4-0 | Shibe Park (6-2) | 51-35 | Won 2 |
| » Starters: Bob Feller vs Dick Fowler | Third | 5½ out |
| Thursday, July 20 |
| » Defeated Athletics (29-57), 3-2 | Shibe Park (7-2) | 52-35 | Won 3 |
| » Starters: Steve Gromek vs Alex Kellner | Third | 4½ out |
| Friday, July 21 |
| » Lost to Senators (40-44), 3-2 | Griffith Stadium (1-5) | 52-36 | |
| » Starters: Mike Garcia vs Connie Marrero | Third | 4½ out |
| Saturday, July 22 |
| » Defeated Senators (40-45), 8-3 | Griffith Stadium (2-5) | 53-36 | |
| » Starters: Early Wynn vs Sid Hudson | Third | 3½ out |
| Sunday, July 23 |
| » Defeated Senators (40-46), 6-2 | Griffith Stadium (3-5) | 54-36 | Won 2 |
| » Starters: Bob Lemon vs Bob Kuzava | Third | 3½ out |
| Tuesday, July 25 |
| » Defeated Athletics (32-59), 7-6 | Cleveland Stadium (27-14) | 55-36 | Won 3 |
| » Starters: Alex Kellner vs Bob Feller | Third | 2½ out |
| Wednesday, July 26 |
| » Defeated Athletics (32-60), 6-2 | Cleveland Stadium (28-14) | 56-36 | Won 4 |
| » Starters: Dick Fowler vs Mike Garcia | Third | 1½ out |
| Thursday, July 27 |
| » Lost to Athletics (33-60), 7-2 | Cleveland Stadium (28-15) | 56-37 | |
| » Starters: Lou Brissie vs Steve Gromek | Third | 2½ out |
| Friday, July 28 |
| » Defeated Red Sox (53-41), 13-1 | Cleveland Stadium (29-15) | 57-37 | |
| » Starters: Mickey McDermott vs Early Wynn | Third | 1½ out |
| Saturday, July 29 |
| » Defeated Red Sox (53-42), 4-1 | Cleveland Stadium (30-15) | 58-37 | Won 2 |
| » Starters: Chuck Stobbs vs Bob Lemon | Third | 1½ out |
| Sunday, July 30 |
| » Defeated Red Sox (53-43), 6-5 | Cleveland Stadium (31-15) | 59-37 | Won 3 |
| » Starters: Walt Masterson vs Bob Feller | Third | 2 out |
| » Lost to Red Sox (54-43), 6-3 | Cleveland Stadium (31-16) | 59-38 | |
| » Starters: Willard Nixon vs Sam Zoldak | Third | 2 out |
| Tuesday, August 1 |
| » Defeated Senators (44-50), 8-2 | Cleveland Stadium (32-16) | 60-38 | |
| » Starters: Sid Hudson vs Early Wynn | Third | 2 out |
| Wednesday, August 2 |
| » Defeated Senators (44-51), 11-0 | Cleveland Stadium (33-16) | 61-38 | Won 2 |
| » Starters: Connie Marrero vs Bob Lemon | Third | 2 out |
| Friday, August 4 |
| » Lost to Yankees (61-38), 1-0 | Cleveland Stadium (33-17) | 61-39 | |
| » Starters: Vic Raschi vs Bob Feller | Third | 2½ out |
| Saturday, August 5 |
| » Defeated Yankees (61-39), 4-2 | Cleveland Stadium (34-17) | 62-39 | |
| » Starters: Eddie Lopat vs Early Wynn | Second | 2½ out |
| Sunday, August 6 |
| » Lost to Yankees (62-39), 9-0 | Cleveland Stadium (34-18) | 62-40 | |
| » Starters: Tommy Byrne vs Bob Lemon | Third | 3½ out |
| Wednesday, August 9 |
| » Defeated Browns (36-65), 4-3 | Sportsman's Park III (6-1) | 63-40 | |
| » Starters: Bob Feller vs Al Widmar | Third | 3½ out |
| » Lost to Browns (37-65), 10-8 | Sportsman's Park III (6-2) | 63-41 | |
| » Starters: Early Wynn vs Dick Starr | Third | 3½ out |
| Former Indian Ed Klepfer dies in Tulsa, OK at the age of 63. |
| Thursday, August 10 |
| » Defeated Browns (37-66), 5-4 | Sportsman's Park III (7-2) | 64-41 | |
| » Starters: Bob Lemon vs Stubby Overmire | Second | 3½ out |
| Friday, August 11 |
| » Defeated White Sox (42-67), 3-2 | Comiskey Park I (3-2) | 65-41 | Won 2 |
| » Starters: Mike Garcia vs Billy Pierce | Second | 3 out |
| Saturday, August 12 |
| » Lost to White Sox (43-67), 11-4 | Comiskey Park I (3-3) | 65-42 | |
| » Starters: Steve Gromek vs Howie Judson | Third | 3½ out |
| Sunday, August 13 |
| » Defeated White Sox (43-68), 5-2 | Comiskey Park I (4-3) | 66-42 | |
| » Starters: Bob Feller vs Bill Wight | Third | 3½ out |
| » Lost to White Sox (44-68), 7-5 | Comiskey Park I (4-4) | 66-43 | |
| » Starters: Dick Weik vs Rae Scarborough | Third | 3½ out |
| Monday, August 14 |
| » Defeated Tigers (67-38), 3-2 | Cleveland Stadium (35-18) | 67-43 | |
| » Starters: Hal Newhouser vs Early Wynn | Second | 2½ out |
| Tuesday, August 15 |
| » Lost to Tigers (68-38), 4-1 | Cleveland Stadium (35-19) | 67-44 | |
| » Starters: Art Houtteman vs Bob Lemon | Third | 3½ out |
| Wednesday, August 16 |
| » Defeated Browns (38-68), 2-0 | Cleveland Stadium (36-19) | 68-44 | |
| » Starters: Al Widmar vs Jesse Flores | Second | 3 out |
| » Defeated Browns (38-69), 2-1 | Cleveland Stadium (37-19) | 69-44 | Won 2 |
| » Starters: Don Johnson vs Mike Garcia | Second | 3 out |
| Thursday, August 17 |
| » Defeated Browns (38-70), 5-4 | Cleveland Stadium (38-19) | 70-44 | Won 3 |
| » Starters: Dick Starr vs Bob Feller | Second | 3 out |
| Future Indian Larry Johnson is born in Cleveland, OH. |
| Saturday, August 19 |
| » Defeated White Sox (44-71), 1-0 | Cleveland Stadium (39-19) | 71-44 | Won 4 |
| » Starters: Ken Holcombe vs Early Wynn | Second | 3 out |
| Sunday, August 20 |
| » Lost to White Sox (45-71), 2-1 | Cleveland Stadium (39-20) | 71-45 | |
| » Starters: Bill Wight vs Bob Lemon | Third | 4 out |
| » Lost to White Sox (46-71), 6-5 | Cleveland Stadium (39-21) | 71-46 | Lost 2 |
| » Starters: Billy Pierce vs Mike Garcia | Third | 4 out |
| » Major-league debuts: Jim Lemon (Indians) |
| Tuesday, August 22 |
| » Defeated Senators (50-62), 5-1 | Griffith Stadium (4-5) | 72-46 | |
| » Starters: Bob Feller vs Gene Bearden | Third | 3½ out |
| Thursday, August 24 |
| » Defeated Senators (50-63), 3-1 | Griffith Stadium (5-5) | 73-46 | Won 2 |
| » Starters: Early Wynn vs Sid Hudson | Third | 2½ out |
| » Defeated Senators (50-64), 5-3 | Griffith Stadium (6-5) | 74-46 | Won 3 |
| » Starters: Bob Lemon vs Sandy Consuegra | Third | 2½ out |
| Friday, August 25 |
| » Defeated Athletics (41-79), 6-2 | Shibe Park (8-2) | 75-46 | Won 4 |
| » Starters: Mike Garcia vs Alex Kellner | Third | 2½ out |
| Saturday, August 26 |
| » Defeated Athletics (41-80), 5-4 | Shibe Park (9-2) | 76-46 | Won 5 |
| » Starters: Jesse Flores vs Joe Coleman | Third | 2½ out |
| Sunday, August 27 |
| » Lost to Red Sox (74-49), 11-9 | Fenway Park (3-7) | 76-47 | |
| » Starters: Bob Feller vs Willard Nixon | Third | 2 out |
| Monday, August 28 |
| » Lost to Red Sox (75-49), 15-14 | Fenway Park (3-8) | 76-48 | Lost 2 |
| » Starters: Bob Lemon vs Mickey McDermott | Third | 2 out |
| Tuesday, August 29 |
| » Lost to Yankees (77-46), 6-5 | Yankee Stadium (4-4) | 76-49 | Lost 3 |
| » Starters: Early Wynn vs Vic Raschi | Third | 2 out |
| Wednesday, August 30 |
| » Lost to Yankees (78-46), 4-3 | Yankee Stadium (4-5) | 76-50 | Lost 4 |
| » Starters: Bob Feller vs Whitey Ford | Fourth | 4 out |
| » Lost to Yankees (79-46), 3-0 | Yankee Stadium (4-6) | 76-51 | Lost 5 |
| » Starters: Mike Garcia vs Eddie Lopat | Fourth | 4 out |
| Thursday, August 31 |
| » Lost to Yankees (80-46), 7-5 | Yankee Stadium (4-7) | 76-52 | Lost 6 |
| » Starters: Bob Lemon vs Tommy Byrne | Fourth | 5 out |
| Saturday, September 2 |
| » Defeated Browns (43-82), 4-2 | Sportsman's Park III (8-2) | 77-52 | |
| » Starters: Early Wynn vs Stubby Overmire | Fourth | 5½ out |
| Sunday, September 3 |
| » Defeated Browns (43-83), 8-1 | Sportsman's Park III (9-2) | 78-52 | Won 2 |
| » Starters: Bob Feller vs Don Johnson | Fourth | 5 out |
| Monday, September 4 |
| » Lost to White Sox (51-79), 7-1 | Comiskey Park I (4-5) | 78-53 | |
| » Starters: Bob Lemon vs Bob Cain | Fourth | 5 out |
| » Defeated White Sox (51-80), 1-0 | Comiskey Park I (5-5) | 79-53 | |
| » Starters: Mike Garcia vs Randy Gumpert | Fourth | 5 out |
| Tuesday, September 5 |
| » Defeated White Sox (51-81), 3-2 | Comiskey Park I (6-5) | 80-53 | Won 2 |
| » Starters: Steve Gromek vs Billy Pierce | Fourth | 4½ out |
| Wednesday, September 6 |
| » Lost to Tigers (82-48), 5-3 | Tiger Stadium (4-4) | 80-54 | |
| » Starters: Early Wynn vs Hal Newhouser | Fourth | 4½ out |
| Thursday, September 7 |
| » Tied Tigers, 13-13 | Tiger Stadium (4-4) | 80-54 | |
| » Starters: Bob Feller vs Art Houtteman | Fourth | 4 out |
| Friday, September 8 |
| » Lost to Browns (46-86), 5-4 | Cleveland Stadium (39-22) | 80-55 | Lost 2 |
| » Starters: Al Widmar vs Mike Garcia | Fourth | 5½ out |
| » Lost to Browns (47-86), 6-0 | Cleveland Stadium (39-23) | 80-56 | Lost 3 |
| » Starters: Don Johnson vs Bob Lemon | Fourth | 5½ out |
| Saturday, September 9 |
| » Lost to Browns (48-86), 2-1 | Cleveland Stadium (39-24) | 80-57 | Lost 4 |
| » Starters: Ned Garver vs Steve Gromek | Fourth | 6½ out |
| Sunday, September 10 |
| » Lost to Browns (49-86), 2-1 | Cleveland Stadium (39-25) | 80-58 | Lost 5 |
| » Starters: Stubby Overmire vs Bob Feller | Fourth | 7 out |
| Tuesday, September 12 |
| » Defeated Yankees (86-50), 8-7 | Cleveland Stadium (40-25) | 81-58 | |
| » Starters: Allie Reynolds vs Early Wynn | Fourth | 7 out |
| Wednesday, September 13 |
| » Lost to Yankees (87-50), 10-3 | Cleveland Stadium (40-26) | 81-59 | |
| » Starters: Eddie Lopat vs Bob Lemon | Fourth | 8 out |
| Friday, September 15 |
| » Defeated Senators (59-78), 4-2 | Cleveland Stadium (41-26) | 82-59 | |
| » Starters: Julio Moreno vs Al Aber | Fourth | 8 out |
| » Lost to Senators (60-78), 4-1 | Cleveland Stadium (41-27) | 82-60 | |
| » Starters: Sid Hudson vs Mike Garcia | Fourth | 8 out |
| » Major-league debuts: Al Aber (Indians) |
| Saturday, September 16 |
| » Defeated Senators (60-79), 5-1 | Cleveland Stadium (42-27) | 83-60 | |
| » Starters: Sandy Consuegra vs Bob Feller | Fourth | 7½ out |
| Sunday, September 17 |
| » Lost to Athletics (49-95), 10-9 | Cleveland Stadium (42-28) | 83-61 | |
| » Starters: Lou Brissie vs Dick Rozek | Fourth | 8 out |
| Wednesday, September 20 |
| » Defeated Red Sox (89-54), 6-3 | Cleveland Stadium (43-28) | 84-61 | |
| » Starters: Chuck Stobbs vs Bob Lemon | Fourth | 7 out |
| » Defeated Red Sox (89-55), 7-1 | Cleveland Stadium (44-28) | 85-61 | Won 2 |
| » Starters: Joe Dobson vs Early Wynn | Fourth | 7 out |
| Friday, September 22 |
| » Defeated Tigers (91-54), 4-3 | Cleveland Stadium (45-28) | 86-61 | Won 3 |
| » Starters: Hal Newhouser vs Bob Feller | Fourth | 6½ out |
| Saturday, September 23 |
| » Defeated Tigers (91-55), 10-2 | Cleveland Stadium (46-28) | 87-61 | Won 4 |
| » Starters: Art Houtteman vs Mike Garcia | Fourth | 6½ out |
| Sunday, September 24 |
| » Defeated Tigers (91-56), 2-1 | Cleveland Stadium (47-28) | 88-61 | Won 5 |
| » Starters: Ted Gray vs Bob Lemon | Fourth | 6½ out |
| Tuesday, September 26 |
| » Defeated White Sox (58-92), 2-0 | Cleveland Stadium (48-28) | 89-61 | Won 6 |
| » Starters: Bob Cain vs Early Wynn | Fourth | 7 out |
| Wednesday, September 27 |
| » Defeated White Sox (58-93), 7-0 | Cleveland Stadium (49-28) | 90-61 | Won 7 |
| » Starters: Rae Scarborough vs Bob Feller | Fourth | 6 out |
| Friday, September 29 |
| » Defeated Tigers (94-58), 12-2 | Tiger Stadium (5-4) | 91-61 | Won 8 |
| » Starters: Bob Lemon vs Ted Gray | Fourth | 6 out |
| Saturday, September 30 |
| » Lost to Tigers (95-58), 3-1 | Tiger Stadium (5-5) | 91-62 | |
| » Starters: Mike Garcia vs Hal Newhouser | Fourth | 7 out |
| Sunday, October 1 |
| » Defeated Tigers (95-59), 7-5 | Tiger Stadium (6-5) | 92-62 | |
| » Starters: Marino Pieretti vs Marlin Stuart | Fourth | 6 out |
| Thursday, October 26 |
| Future Indian Wayne Garland is born in Nashville, TN. |
| Sunday, November 26 |
| Future Indian Jorge Orta is born in Mazatlan, Mexico. |
| Wednesday, November 29 |
| Future Indian Otto Velez is born in Ponce, P.R. |
| Tuesday, December 12 |
| Future Indian Gorman Thomas is born in Charleston, SC. |
| Monday, December 25 |
| Future Indian Manny Trillo is born in Caripito, Venezuela. |
Game information provided by Retrosheet (www.retrosheet.org) |
