| Saturday, January 15 |
| Future White Sox Luis Alvarado is born in Lajas, P.R. |
| Friday, January 28 |
| Former White Sox Frank Naleway dies in Chicago, IL at the age of 47. |
| Monday, January 31 |
| Future White Sox Jim Willoughby is born in Salinas, CA. |
| Sunday, February 6 |
| Future White Sox Richie Zisk is born in Brooklyn, NY. |
| Thursday, March 3 |
| Future White Sox Jesse Jefferson is born in Midlothian, VA. |
| Friday, March 11 |
| Former White Sox Eric McNair dies in Meridian, MS at the age of 40. |
| Sunday, March 13 |
| Future White Sox Denny O'Toole is born in Chicago, IL. |
| Tuesday, March 15 |
| Former White Sox Bill Cissell dies in Chicago, IL at the age of 46. |
| Saturday, April 9 |
| Future White Sox Sam Ewing is born in Lewisburg, TN. |
| Tuesday, April 19 |
| » Lost to Tigers (1-0), 5-1 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Al Gettel vs Hal Newhouser | Third | 1 out |
| » Major-league debuts: Max Surkont and Gus Zernial (White Sox) |
| Wednesday, April 20 |
| » Lost to Tigers (2-0), 5-2 | Tiger Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Randy Gumpert vs Virgil Trucks | Fifth | 2 out |
| » Major-league debuts: Gordon Goldsberry (White Sox) |
| Thursday, April 21 |
| » Defeated Tigers (2-1), 5-2 | Tiger Stadium (1-2) | 1-2 | |
| » Starters: Howie Judson vs Lou Kretlow | Fourth | 2 out |
| » Major-league debuts: Bill Evans (White Sox) |
| Friday, April 22 |
| » Defeated Browns (1-3), 5-2 | Comiskey Park I (1-0) | 2-2 | Won 2 |
| » Starters: Red Embree vs Marino Pieretti | Fourth | 2 out |
| Saturday, April 23 |
| » Defeated Browns (1-4), 12-5 | Comiskey Park I (2-0) | 3-2 | Won 3 |
| » Starters: Bill Kennedy vs Al Gettel | Third | 1 out |
| Sunday, April 24 |
| » Defeated Browns (1-5), 2-1 | Comiskey Park I (3-0) | 4-2 | Won 4 |
| » Starters: Ned Garver vs Bill Wight | Second | ½ out |
| » Defeated Browns (1-6), 4-0 | Comiskey Park I (4-0) | 5-2 | Won 5 |
| » Starters: Dick Starr vs Randy Gumpert | Second | ½ out |
| Monday, April 25 |
| » Major-league debuts: Frank Fanovich (Reds) |
| Tuesday, April 26 |
| » Lost to Tigers (4-2), 6-2 | Comiskey Park I (4-1) | 5-3 | |
| » Starters: Virgil Trucks vs Howie Judson | Fourth | 2½ out |
| » Lost to Tigers (5-2), 7-5 | Comiskey Park I (4-2) | 5-4 | Lost 2 |
| » Starters: Lou Kretlow vs Max Surkont | Fourth | 2½ out |
| » Major-league debuts: Marlin Stuart (Tigers) |
| Wednesday, April 27 |
| » Lost to Indians (5-2), 11-3 | Cleveland Stadium (0-1) | 5-5 | Lost 3 |
| » Starters: Marino Pieretti vs Steve Gromek | Fifth | 2½ out |
| Thursday, April 28 |
| » Major-league debuts: Saul Rogovin (Tigers) |
| Former White Sox Clay Touchstone dies in Beaumont, TX at the age of 47. |
| Saturday, April 30 |
| » Defeated Browns (3-8), 5-4 | Sportsman's Park III (1-0) | 6-5 | |
| » Starters: Billy Pierce vs Dick Starr | Third | 3½ out |
| Sunday, May 1 |
| » Defeated Browns (3-9), 7-6 | Sportsman's Park III (2-0) | 7-5 | Won 2 |
| » Starters: Bill Wight vs Karl Drews | Second | 2 out |
| » Defeated Browns (3-10), 14-11 | Sportsman's Park III (3-0) | 8-5 | Won 3 |
| » Starters: Fred Bradley vs Red Embree | Second | 2 out |
| Tuesday, May 3 |
| » Lost to Senators (4-11), 14-12 | Comiskey Park I (4-3) | 8-6 | |
| » Starters: Ray Scarborough vs Randy Gumpert | Fourth | 3 out |
| Wednesday, May 4 |
| » Lost to Senators (5-11), 8-7 | Comiskey Park I (4-4) | 8-7 | Lost 2 |
| » Starters: Sid Hudson vs Marino Pieretti | Fourth | 4 out |
| Thursday, May 5 |
| » Lost to Yankees (13-3), 7-5 | Comiskey Park I (4-5) | 8-8 | Lost 3 |
| » Starters: Allie Reynolds vs Billy Pierce | Fourth | 5 out |
| Friday, May 6 |
| » Defeated Yankees (13-4), 6-2 | Comiskey Park I (5-5) | 9-8 | |
| » Starters: Spec Shea vs Bill Wight | Fourth | 4 out |
| Saturday, May 7 |
| » Lost to Yankees (14-4), 8-1 | Comiskey Park I (5-6) | 9-9 | |
| » Starters: Bob Porterfield vs Al Gettel | Fourth | 5 out |
| Sunday, May 8 |
| » Defeated Athletics (9-11), 11-3 | Comiskey Park I (6-6) | 10-9 | |
| » Starters: Alex Kellner vs Randy Gumpert | Fourth | 5½ out |
| » Lost to Athletics (10-11), 3-2 | Comiskey Park I (6-7) | 10-10 | |
| » Starters: Bill McCahan vs Howie Judson | Fourth | 5½ out |
| Tuesday, May 10 |
| » Lost to Athletics (11-11), 5-0 | Comiskey Park I (6-8) | 10-11 | Lost 2 |
| » Starters: Joe Coleman vs Billy Pierce | Fifth | 6 out |
| Wednesday, May 11 |
| » Defeated Red Sox (8-11), 12-8 | Comiskey Park I (7-8) | 11-11 | |
| » Starters: Tex Hughson vs Bill Wight | Fifth | 5 out |
| Thursday, May 12 |
| » Lost to Red Sox (9-11), 2-1 | Comiskey Park I (7-9) | 11-12 | |
| » Starters: Mel Parnell vs Randy Gumpert | Fifth | 5½ out |
| Friday, May 13 |
| » Defeated Indians (10-8), 11-10 | Comiskey Park I (8-9) | 12-12 | |
| » Starters: Early Wynn vs Billy Pierce | Fourth | 5 out |
| Sunday, May 15 |
| » Defeated Indians (10-9), 10-0 | Comiskey Park I (9-9) | 13-12 | Won 2 |
| » Starters: Bob Feller vs Bill Wight | Third | 2½ out |
| » Defeated Indians (10-10), 2-0 | Comiskey Park I (10-9) | 14-12 | Won 3 |
| » Starters: Steve Gromek vs Al Gettel | Third | 2½ out |
| Tuesday, May 17 |
| » Lost to Red Sox (11-13), 4-3 | Fenway Park (0-1) | 14-13 | |
| » Starters: Randy Gumpert vs Mel Parnell | Fourth | 3½ out |
| Wednesday, May 18 |
| » Lost to Red Sox (12-13), 7-4 | Fenway Park (0-2) | 14-14 | Lost 2 |
| » Starters: Marino Pieretti vs Ellis Kinder | Fourth | 4½ out |
| Thursday, May 19 |
| » Defeated Red Sox (12-14), 7-6 | Fenway Park (1-2) | 15-14 | |
| » Starters: Al Gettel vs Chuck Stobbs | Third | 3½ out |
| Saturday, May 21 |
| » Lost to Yankees (19-10), 4-3 | Yankee Stadium (0-1) | 15-15 | |
| » Starters: Bill Wight vs Spec Shea | Fifth | 4½ out |
| Sunday, May 22 |
| » Defeated Senators (17-16), 6-4 | Griffith Stadium (1-0) | 16-15 | |
| » Starters: Billy Pierce vs Walt Masterson | Third | 4 out |
| Monday, May 23 |
| » Defeated Senators (17-17), 3-1 | Griffith Stadium (2-0) | 17-15 | Won 2 |
| » Starters: Randy Gumpert vs Joe Haynes | Third | 4 out |
| Wednesday, May 25 |
| » Lost to Athletics (20-15), 6-4 | Shibe Park (0-1) | 17-16 | |
| » Starters: Marino Pieretti vs Dick Fowler | Fourth | 5½ out |
| Friday, May 27 |
| » Lost to Indians (13-17), 4-0 | Cleveland Stadium (0-2) | 17-17 | Lost 2 |
| » Starters: Bill Wight vs Al Benton | Fifth | 6½ out |
| Saturday, May 28 |
| » Lost to Indians (14-17), 3-2 | Cleveland Stadium (0-3) | 17-18 | Lost 3 |
| » Starters: Howie Judson vs Early Wynn | Sixth | 7½ out |
| Sunday, May 29 |
| » Defeated Indians (14-18), 4-2 | Cleveland Stadium (1-3) | 18-18 | |
| » Starters: Randy Gumpert vs Steve Gromek | Sixth | 7 out |
| » Lost to Indians (15-18), 2-1 | Cleveland Stadium (1-4) | 18-19 | |
| » Starters: Billy Pierce vs Satchel Paige | Sixth | 7 out |
| Monday, May 30 |
| » Lost to Tigers (20-18), 3-2 | Comiskey Park I (10-10) | 18-20 | Lost 2 |
| » Starters: Fred Hutchinson vs Max Surkont | Fifth | 7 out |
| » Defeated Tigers (20-19), 2-1 | Comiskey Park I (11-10) | 19-20 | |
| » Starters: Hal Newhouser vs Bill Wight | Fifth | 7 out |
| Wednesday, June 1 |
| » Lost to Yankees (26-12), 3-0 | Comiskey Park I (11-11) | 19-21 | |
| » Starters: Vic Raschi vs Howie Judson | Sixth | 8 out |
| Thursday, June 2 |
| » Lost to Yankees (27-12), 12-7 | Comiskey Park I (11-12) | 19-22 | Lost 2 |
| » Starters: Ed Lopat vs Randy Gumpert | Seventh | 9 out |
| Friday, June 3 |
| » Lost to Yankees (28-12), 9-7 | Comiskey Park I (11-13) | 19-23 | Lost 3 |
| » Starters: Bob Porterfield vs Billy Pierce | Seventh | 10 out |
| Saturday, June 4 |
| » Defeated Senators (24-20), 2-1 | Comiskey Park I (12-13) | 20-23 | |
| » Starters: Walt Masterson vs Bill Wight | Seventh | 10 out |
| Sunday, June 5 |
| » Lost to Senators (25-20), 7-6 | Comiskey Park I (12-14) | 20-24 | |
| » Starters: Joe Haynes vs Randy Gumpert | Sixth | 10 out |
| » Defeated Senators (25-21), 5-4 | Comiskey Park I (13-14) | 21-24 | |
| » Starters: Sid Hudson vs Al Gettel | Sixth | 10 out |
| Tuesday, June 7 |
| » Lost to Athletics (25-23), 7-4 | Comiskey Park I (13-15) | 21-25 | |
| » Starters: Lou Brissie vs Howie Judson | Seventh | 10 out |
| Wednesday, June 8 |
| » Lost to Athletics (26-23), 5-2 | Comiskey Park I (13-16) | 21-26 | Lost 2 |
| » Starters: Alex Kellner vs Marino Pieretti | Seventh | 10 out |
| Thursday, June 9 |
| » Lost to Athletics (27-23), 1-0 | Comiskey Park I (13-17) | 21-27 | Lost 3 |
| » Starters: Dick Fowler vs Bill Wight | Seventh | 10 out |
| Friday, June 10 |
| » Defeated Red Sox (23-24), 4-2 | Comiskey Park I (14-17) | 22-27 | |
| » Starters: Earl Johnson vs Randy Gumpert | Seventh | 10 out |
| Sunday, June 12 |
| » Lost to Red Sox (24-24), 15-3 | Comiskey Park I (14-18) | 22-28 | |
| » Starters: Mel Parnell vs Howie Judson | Seventh | 10½ out |
| » Lost to Red Sox (25-24), 7-5 | Comiskey Park I (14-19) | 22-29 | Lost 2 |
| » Starters: Ellis Kinder vs Billy Pierce | Seventh | 10½ out |
| Tuesday, June 14 |
| » Lost to Yankees (33-18), 15-3 | Yankee Stadium (0-2) | 22-30 | Lost 3 |
| » Starters: Bill Wight vs Vic Raschi | Seventh | 11½ out |
| Wednesday, June 15 |
| » Lost to Yankees (34-18), 9-4 | Yankee Stadium (0-3) | 22-31 | Lost 4 |
| » Starters: Randy Gumpert vs Allie Reynolds | Seventh | 12½ out |
| Thursday, June 16 |
| » Defeated Yankees (34-19), 10-6 | Yankee Stadium (1-3) | 23-31 | |
| » Starters: Billy Pierce vs Tommy Byrne | Seventh | 12½ out |
| » Lost to Yankees (35-19), 5-4 | Yankee Stadium (1-4) | 23-32 | |
| » Starters: Bob Kuzava vs Fred Sanford | Seventh | 12½ out |
| Friday, June 17 |
| » Lost to Red Sox (26-27), 4-3 | Fenway Park (1-3) | 23-33 | Lost 2 |
| » Starters: Howie Judson vs Joe Dobson | Seventh | 13 out |
| » Lost to Red Sox (27-27), 10-8 | Fenway Park (1-4) | 23-34 | Lost 3 |
| » Starters: Bill Wight vs Mickey McDermott | Seventh | 13 out |
| Saturday, June 18 |
| » Lost to Red Sox (28-27), 7-5 | Fenway Park (1-5) | 23-35 | Lost 4 |
| » Starters: Billy Pierce vs Ellis Kinder | Seventh | 14 out |
| Sunday, June 19 |
| » Lost to Red Sox (29-27), 9-2 | Fenway Park (1-6) | 23-36 | Lost 5 |
| » Starters: Randy Gumpert vs Chuck Stobbs | Seventh | 14 out |
| Future White Sox Jerry Reuss is born in St. Louis, MO. |
| Monday, June 20 |
| » Defeated Senators (28-29), 5-4 | Griffith Stadium (3-0) | 24-36 | |
| » Starters: Bob Kuzava vs Ray Scarborough | Seventh | 14 out |
| Tuesday, June 21 |
| » Lost to Senators (29-29), 9-3 | Griffith Stadium (3-1) | 24-37 | |
| » Starters: Al Gettel vs Sid Hudson | Seventh | 14½ out |
| Wednesday, June 22 |
| » Defeated Senators (29-30), 4-1 | Griffith Stadium (4-1) | 25-37 | |
| » Starters: Bill Wight vs Lloyd Hittle | Seventh | 14 out |
| Thursday, June 23 |
| » Lost to Athletics (35-27), 11-4 | Shibe Park (0-2) | 25-38 | |
| » Starters: Howie Judson vs Alex Kellner | Seventh | 15 out |
| Friday, June 24 |
| » Defeated Athletics (35-28), 2-1 | Shibe Park (1-2) | 26-38 | |
| » Starters: Randy Gumpert vs Carl Scheib | Seventh | 15 out |
| Saturday, June 25 |
| » Lost to Athletics (36-28), 7-6 | Shibe Park (1-3) | 26-39 | |
| » Starters: Howie Judson vs Dick Fowler | Seventh | 15 out |
| Sunday, June 26 |
| » Lost to Athletics (37-28), 4-2 | Shibe Park (1-4) | 26-40 | Lost 2 |
| » Starters: Bill Wight vs Lou Brissie | Seventh | 15 out |
| » Defeated Athletics (37-29), 3-0 | Shibe Park (2-4) | 27-40 | |
| » Starters: Bob Kuzava vs Joe Coleman | Seventh | 15 out |
| Tuesday, June 28 |
| » Lost to Browns (19-46), 7-6 | Comiskey Park I (14-20) | 27-41 | |
| » Starters: Red Embree vs Randy Gumpert | Seventh | 16 out |
| Wednesday, June 29 |
| » Lost to Browns (20-46), 1-0 | Comiskey Park I (14-21) | 27-42 | Lost 2 |
| » Starters: Ned Garver vs Billy Pierce | Seventh | 17 out |
| Friday, July 1 |
| » Defeated Tigers (38-32), 4-0 | Tiger Stadium (2-2) | 28-42 | |
| » Starters: Bill Wight vs Fred Hutchinson | Seventh | 17½ out |
| Saturday, July 2 |
| » Lost to Tigers (39-32), 7-6 | Tiger Stadium (2-3) | 28-43 | |
| » Starters: Bob Kuzava vs Virgil Trucks | Seventh | 18½ out |
| Sunday, July 3 |
| » Defeated Tigers (39-33), 8-4 | Tiger Stadium (3-3) | 29-43 | |
| » Starters: Marino Pieretti vs Ted Gray | Seventh | 17½ out |
| Monday, July 4 |
| » Defeated Browns (21-50), 12-5 | Sportsman's Park III (4-0) | 30-43 | Won 2 |
| » Starters: Randy Gumpert vs Red Embree | Seventh | 18½ out |
| » Lost to Browns (22-50), 4-2 | Sportsman's Park III (4-1) | 30-44 | |
| » Starters: Billy Pierce vs Ned Garver | Seventh | 18½ out |
| Tuesday, July 5 |
| » Lost to Browns (23-50), 9-5 | Sportsman's Park III (4-2) | 30-45 | Lost 2 |
| » Starters: Bill Wight vs Joe Ostrowski | Seventh | 18½ out |
| Wednesday, July 6 |
| » Defeated Indians (41-32), 9-6 | Comiskey Park I (15-21) | 31-45 | |
| » Starters: Steve Gromek vs Bob Kuzava | Seventh | 18 out |
| Thursday, July 7 |
| » Lost to Indians (42-32), 8-2 | Comiskey Park I (15-22) | 31-46 | |
| » Starters: Bob Lemon vs Marino Pieretti | Seventh | 19 out |
| Future White Sox Tim Nordbrook is born in Baltimore, MD. |
| Friday, July 8 |
| » Defeated Tigers (40-38), 3-1 | Comiskey Park I (16-22) | 32-46 | |
| » Starters: Ted Gray vs Billy Pierce | Seventh | 19 out |
| Sunday, July 10 |
| » Defeated Tigers (40-39), 4-2 | Comiskey Park I (17-22) | 33-46 | Won 2 |
| » Starters: Hal Newhouser vs Bill Wight | Seventh | 18½ out |
| » Lost to Tigers (41-39), 1-0 | Comiskey Park I (17-23) | 33-47 | |
| » Starters: Art Houtteman vs Randy Gumpert | Seventh | 18½ out |
| Thursday, July 14 |
| » Defeated Senators (33-42), 6-2 | Comiskey Park I (18-23) | 34-47 | |
| » Starters: Sid Hudson vs Billy Pierce | Seventh | 18½ out |
| Friday, July 15 |
| » Lost to Senators (34-42), 9-4 | Comiskey Park I (18-24) | 34-48 | |
| » Starters: Mickey Harris vs Bill Wight | Seventh | 19½ out |
| Saturday, July 16 |
| » Defeated Senators (34-43), 5-1 | Comiskey Park I (19-24) | 35-48 | |
| » Starters: Ray Scarborough vs Bob Kuzava | Seventh | 18½ out |
| Sunday, July 17 |
| » Lost to Yankees (53-28), 2-1 | Comiskey Park I (19-25) | 35-49 | |
| » Starters: Vic Raschi vs Randy Gumpert | Seventh | 18½ out |
| » Defeated Yankees (53-29), 7-3 | Comiskey Park I (20-25) | 36-49 | |
| » Starters: Fred Sanford vs Billy Pierce | Seventh | 18½ out |
| » Major-league debuts: Eddie Malone (White Sox) |
| Former White Sox Jack Slattery dies in Boston, MA at the age of 72. |
| Monday, July 18 |
| » Defeated Yankees (53-30), 6-5 | Comiskey Park I (21-25) | 37-49 | Won 2 |
| » Starters: Cuddles Marshall vs Bill Wight | Seventh | 17½ out |
| Tuesday, July 19 |
| » Lost to Red Sox (45-39), 6-4 | Comiskey Park I (21-26) | 37-50 | |
| » Starters: Ellis Kinder vs Marino Pieretti | Seventh | 17½ out |
| Wednesday, July 20 |
| » Defeated Red Sox (45-40), 8-7 | Comiskey Park I (22-26) | 38-50 | |
| » Starters: Earl Johnson vs Bob Kuzava | Sixth | 17½ out |
| Friday, July 22 |
| » Defeated Athletics (47-43), 12-0 | Comiskey Park I (23-26) | 39-50 | Won 2 |
| » Starters: Carl Scheib vs Randy Gumpert | Fifth | 18 out |
| Sunday, July 24 |
| » Lost to Athletics (48-43), 7-2 | Comiskey Park I (23-27) | 39-51 | |
| » Starters: Joe Coleman vs Billy Pierce | Sixth | 19 out |
| » Lost to Athletics (49-43), 6-4 | Comiskey Park I (23-28) | 39-52 | Lost 2 |
| » Starters: Dick Fowler vs Bill Wight | Sixth | 19 out |
| Tuesday, July 26 |
| » Lost to Red Sox (49-41), 11-2 | Fenway Park (1-7) | 39-53 | Lost 3 |
| » Starters: Bob Kuzava vs Mickey McDermott | Sixth | 19 out |
| Wednesday, July 27 |
| » Lost to Red Sox (50-41), 6-0 | Fenway Park (1-8) | 39-54 | Lost 4 |
| » Starters: Randy Gumpert vs Mel Parnell | Sixth | 19½ out |
| Thursday, July 28 |
| » Lost to Red Sox (51-41), 6-1 | Fenway Park (1-9) | 39-55 | Lost 5 |
| » Starters: Howie Judson vs Ellis Kinder | Sixth | 20½ out |
| Friday, July 29 |
| » Lost to Yankees (59-33), 3-2 | Yankee Stadium (1-5) | 39-56 | Lost 6 |
| » Starters: Mickey Haefner vs Tommy Byrne | Sixth | 21½ out |
| Saturday, July 30 |
| » Defeated Yankees (59-34), 9-2 | Yankee Stadium (2-5) | 40-56 | |
| » Starters: Bill Wight vs Vic Raschi | Sixth | 20½ out |
| Sunday, July 31 |
| » Lost to Yankees (60-34), 3-2 | Yankee Stadium (2-6) | 40-57 | |
| » Starters: Billy Pierce vs Ed Lopat | Sixth | 20½ out |
| » Defeated Yankees (60-35), 2-1 | Yankee Stadium (3-6) | 41-57 | |
| » Starters: Bob Kuzava vs Duane Pillette | Sixth | 20½ out |
| Tuesday, August 2 |
| » Lost to Athletics (54-46), 5-2 | Shibe Park (2-5) | 41-58 | |
| » Starters: Randy Gumpert vs Carl Scheib | Sixth | 20½ out |
| Wednesday, August 3 |
| » Lost to Athletics (55-46), 3-2 | Shibe Park (2-6) | 41-59 | Lost 2 |
| » Starters: Bill Wight vs Joe Coleman | Sixth | 21½ out |
| Friday, August 5 |
| » Defeated Senators (36-62), 4-1 | Griffith Stadium (5-1) | 42-59 | |
| » Starters: Mickey Haefner vs Sid Hudson | Sixth | 21½ out |
| Saturday, August 6 |
| » Defeated Senators (36-63), 6-5 | Griffith Stadium (6-1) | 43-59 | Won 2 |
| » Starters: Bob Kuzava vs Ray Scarborough | Sixth | 21½ out |
| Sunday, August 7 |
| » Defeated Senators (36-64), 4-1 | Griffith Stadium (7-1) | 44-59 | Won 3 |
| » Starters: Randy Gumpert vs Mickey Harris | Sixth | 22 out |
| » Lost to Senators (37-64), 1-0 | Griffith Stadium (7-2) | 44-60 | |
| » Starters: Billy Pierce vs Lloyd Hittle | Sixth | 22 out |
| Tuesday, August 9 |
| » Lost to Tigers (58-49), 11-5 | Tiger Stadium (3-4) | 44-61 | Lost 2 |
| » Starters: Bill Wight vs Fred Hutchinson | Sixth | 22 out |
| Wednesday, August 10 |
| » Defeated Tigers (58-50), 6-3 | Tiger Stadium (4-4) | 45-61 | |
| » Starters: Mickey Haefner vs Hal Newhouser | Sixth | 22 out |
| Thursday, August 11 |
| » Lost to Indians (62-44), 6-5 | Cleveland Stadium (1-5) | 45-62 | |
| » Starters: Bob Kuzava vs Mike Garcia | Sixth | 22 out |
| » Major-league debuts: Luke Easter (Indians) |
| Friday, August 12 |
| » Defeated Indians (62-45), 6-5 | Cleveland Stadium (2-5) | 46-62 | |
| » Starters: Randy Gumpert vs Early Wynn | Sixth | 22 out |
| Sunday, August 14 |
| » Lost to Indians (63-45), 4-3 | Cleveland Stadium (2-6) | 46-63 | |
| » Starters: Mickey Haefner vs Bob Lemon | Sixth | 23½ out |
| » Lost to Indians (64-45), 5-0 | Cleveland Stadium (2-7) | 46-64 | Lost 2 |
| » Starters: Billy Pierce vs Mike Garcia | Sixth | 23½ out |
| Monday, August 15 |
| » Defeated Browns (35-76), 8-0 | Sportsman's Park III (5-2) | 47-64 | |
| » Starters: Bill Wight vs Cliff Fannin | Sixth | 22½ out |
| Tuesday, August 16 |
| » Defeated Browns (35-77), 4-0 | Sportsman's Park III (6-2) | 48-64 | Won 2 |
| » Starters: Bob Kuzava vs Joe Ostrowski | Sixth | 22 out |
| Wednesday, August 17 |
| » Defeated Tigers (62-53), 1-0 | Comiskey Park I (24-28) | 49-64 | Won 3 |
| » Starters: Ted Gray vs Mickey Haefner | Sixth | 22 out |
| Thursday, August 18 |
| » Lost to Tigers (63-53), 2-0 | Comiskey Park I (24-29) | 49-65 | |
| » Starters: Fred Hutchinson vs Billy Pierce | Sixth | 23 out |
| Friday, August 19 |
| » Lost to Indians (68-47), 2-0 | Comiskey Park I (24-30) | 49-66 | Lost 2 |
| » Starters: Mike Garcia vs Randy Gumpert | Sixth | 24 out |
| Sunday, August 21 |
| » Defeated Indians (68-48), 5-4 | Comiskey Park I (25-30) | 50-66 | |
| » Starters: Bob Feller vs Bill Wight | Sixth | 24 out |
| » Lost to Indians (69-48), 7-4 | Comiskey Park I (25-31) | 50-67 | |
| » Starters: Early Wynn vs Bob Kuzava | Sixth | 24 out |
| Tuesday, August 23 |
| » Lost to Athletics (64-54), 4-2 | Comiskey Park I (25-32) | 50-68 | Lost 2 |
| » Starters: Joe Coleman vs Mickey Haefner | Sixth | 24 out |
| Wednesday, August 24 |
| » Lost to Athletics (65-54), 5-0 | Comiskey Park I (25-33) | 50-69 | Lost 3 |
| » Starters: Dick Fowler vs Randy Gumpert | Sixth | 24 out |
| Thursday, August 25 |
| » Defeated Red Sox (72-48), 8-3 | Comiskey Park I (26-33) | 51-69 | |
| » Starters: Mickey McDermott vs Billy Pierce | Sixth | 24 out |
| Friday, August 26 |
| » Lost to Red Sox (73-48), 11-4 | Comiskey Park I (26-34) | 51-70 | |
| » Starters: Mel Parnell vs Bill Wight | Sixth | 24½ out |
| » Lost to Red Sox (74-48), 10-7 | Comiskey Park I (26-35) | 51-71 | Lost 2 |
| » Starters: Ellis Kinder vs Bob Kuzava | Sixth | 24½ out |
| Saturday, August 27 |
| » Lost to Red Sox (75-48), 7-2 | Comiskey Park I (26-36) | 51-72 | Lost 3 |
| » Starters: Chuck Stobbs vs Howie Judson | Sixth | 25½ out |
| Sunday, August 28 |
| » Lost to Yankees (76-45), 8-7 | Comiskey Park I (26-37) | 51-73 | Lost 4 |
| » Starters: Fred Sanford vs Mickey Haefner | Sixth | 27½ out |
| » Lost to Yankees (77-45), 7-5 | Comiskey Park I (26-38) | 51-74 | Lost 5 |
| » Starters: Allie Reynolds vs Randy Gumpert | Sixth | 27½ out |
| Tuesday, August 30 |
| » Lost to Senators (42-82), 1-0 | Comiskey Park I (26-39) | 51-75 | Lost 6 |
| » Starters: Lloyd Hittle vs Bill Wight | Sixth | 27½ out |
| Wednesday, August 31 |
| » Defeated Senators (42-83), 4-2 | Comiskey Park I (27-39) | 52-75 | |
| » Starters: Sid Hudson vs Billy Pierce | Sixth | 26½ out |
| Thursday, September 1 |
| » Defeated Senators (42-84), 3-0 | Comiskey Park I (28-39) | 53-75 | Won 2 |
| » Starters: Dick Weik vs Randy Gumpert | Sixth | 26½ out |
| Friday, September 2 |
| » Lost to Tigers (74-58), 8-0 | Tiger Stadium (4-5) | 53-76 | |
| » Starters: Mickey Haefner vs Virgil Trucks | Sixth | 27 out |
| Saturday, September 3 |
| » Lost to Tigers (75-58), 5-3 | Tiger Stadium (4-6) | 53-77 | Lost 2 |
| » Starters: Bill Wight vs Ted Gray | Sixth | 28 out |
| Sunday, September 4 |
| » Lost to Tigers (76-58), 5-4 | Tiger Stadium (4-7) | 53-78 | Lost 3 |
| » Starters: Billy Pierce vs Hal Newhouser | Sixth | 28 out |
| Monday, September 5 |
| » Lost to Indians (77-54), 5-3 | Cleveland Stadium (2-8) | 53-79 | Lost 4 |
| » Starters: Randy Gumpert vs Al Benton | Sixth | 30 out |
| » Lost to Indians (78-54), 6-4 | Cleveland Stadium (2-9) | 53-80 | Lost 5 |
| » Starters: Mickey Haefner vs Bob Lemon | Sixth | 30 out |
| Wednesday, September 7 |
| » Defeated Browns (48-87), 7-1 | Comiskey Park I (29-39) | 54-80 | |
| » Starters: Cliff Fannin vs Bill Wight | Sixth | 30 out |
| Thursday, September 8 |
| » Defeated Browns (48-88), 3-1 | Comiskey Park I (30-39) | 55-80 | Won 2 |
| » Starters: Ned Garver vs Bob Kuzava | Sixth | 29½ out |
| Saturday, September 10 |
| » Lost to Tigers (81-58), 8-3 | Comiskey Park I (30-40) | 55-81 | |
| » Starters: Fred Hutchinson vs Billy Pierce | Sixth | 29½ out |
| Sunday, September 11 |
| » Lost to Tigers (82-58), 1-0 | Comiskey Park I (30-41) | 55-82 | Lost 2 |
| » Starters: Virgil Trucks vs Bill Wight | Sixth | 31 out |
| Tuesday, September 13 |
| » Defeated Senators (44-94), 3-2 | Griffith Stadium (8-2) | 56-82 | |
| » Starters: Randy Gumpert vs Dick Weik | Sixth | 30½ out |
| » Major-league debuts: Hal Keller (Senators) |
| Wednesday, September 14 |
| » Defeated Senators (44-95), 8-1 | Griffith Stadium (9-2) | 57-82 | Won 2 |
| » Starters: Bob Kuzava vs Lloyd Hittle | Sixth | 31 out |
| » Major-league debuts: Jim Baumer (White Sox) |
| Friday, September 16 |
| » Lost to Athletics (74-66), 5-1 | Shibe Park (2-7) | 57-83 | |
| » Starters: Billy Pierce vs Dick Fowler | Sixth | 31 out |
| » Defeated Athletics (74-67), 6-3 | Shibe Park (3-7) | 58-83 | |
| » Starters: Bill Wight vs Joe Coleman | Sixth | 31 out |
| Saturday, September 17 |
| » Defeated Athletics (74-68), 8-5 | Shibe Park (4-7) | 59-83 | Won 2 |
| » Starters: Mickey Haefner vs Carl Scheib | Sixth | 31 out |
| Sunday, September 18 |
| » Lost to Red Sox (89-55), 11-5 | Fenway Park (1-10) | 59-84 | |
| » Starters: Randy Gumpert vs Ellis Kinder | Sixth | 32 out |
| » Major-league debuts: Bob Cain (White Sox) |
| Tuesday, September 20 |
| » Lost to Yankees (92-51), 3-1 | Yankee Stadium (3-7) | 59-85 | Lost 2 |
| » Starters: Bob Kuzava vs Allie Reynolds | Sixth | 33½ out |
| Wednesday, September 21 |
| » Defeated Yankees (92-52), 10-9 | Yankee Stadium (4-7) | 60-85 | |
| » Starters: Billy Pierce vs Tommy Byrne | Sixth | 32½ out |
| Thursday, September 22 |
| » Major-league debuts: Steve Bilko (Cardinals) |
| Friday, September 23 |
| » Defeated Browns (50-99), 4-1 | Comiskey Park I (31-41) | 61-85 | Won 2 |
| » Starters: Ribs Raney vs Randy Gumpert | Sixth | 32 out |
| Saturday, September 24 |
| Future White Sox Don Kirkwood is born in Pontiac, MI. |
| Sunday, September 25 |
| » Defeated Browns (50-100), 7-5 | Comiskey Park I (32-41) | 62-85 | Won 3 |
| » Starters: Cliff Fannin vs Bill Wight | Fifth | 31 out |
| » Lost to Browns (51-100), 6-2 | Comiskey Park I (32-42) | 62-86 | |
| » Starters: Dick Starr vs Jack Bruner | Fifth | 31 out |
| Tuesday, September 27 |
| » Lost to Indians (84-65), 3-2 | Comiskey Park I (32-43) | 62-87 | Lost 2 |
| » Starters: Mike Garcia vs Mickey Haefner | Sixth | 32½ out |
| Wednesday, September 28 |
| » Lost to Indians (85-65), 4-2 | Comiskey Park I (32-44) | 62-88 | Lost 3 |
| » Starters: Bob Lemon vs Jack Bruner | Fifth | 32½ out |
| Thursday, September 29 |
| » Lost to Indians (86-65), 8-3 | Comiskey Park I (32-45) | 62-89 | Lost 4 |
| » Starters: Early Wynn vs Bob Kuzava | Fifth | 33 out |
| Saturday, October 1 |
| » Lost to Browns (52-100), 8-6 | Sportsman's Park III (6-3) | 62-90 | Lost 5 |
| » Starters: Randy Gumpert vs Ribs Raney | Fifth | 33½ out |
| Sunday, October 2 |
| » Defeated Browns (52-101), 4-3 | Sportsman's Park III (7-3) | 63-90 | |
| » Starters: Bill Wight vs Ned Garver | Sixth | 34 out |
| » Lost to Browns (53-101), 5-3 | Sportsman's Park III (7-4) | 63-91 | |
| » Starters: Mickey Haefner vs Ed Albrecht | Sixth | 34 out |
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