| Saturday, January 15 |
| Future Indian Luis Alvarado is born in Lajas, P.R. |
| Monday, January 31 |
| Future Indian Fred Kendall is born in Torrance, CA. |
| Thursday, February 3 |
| Future Indian Bake McBride is born in Fulton, MO. |
| Tuesday, March 15 |
| Future Indian Jim Kern is born in Gladwin, MI. Former Indian Bill Cissell dies in Chicago, IL at the age of 46. |
| Wednesday, March 30 |
| Former Indian Bill Bernhard dies in San Diego, CA at the age of 79. |
| Tuesday, April 19 |
| » Lost to Browns (1-0), 5-1 | Sportsman's Park III (0-1) | 0-1 | |
| » Starters: Bob Feller vs Ned Garver | Third | 1 out |
| » Major-league debuts: Freddie Marsh and Minnie Minoso (Indians) |
| Wednesday, April 20 |
| » Defeated Browns (1-1), 7-3 | Sportsman's Park III (1-1) | 1-1 | |
| » Starters: Bob Lemon vs Karl Drews | Third | 1 out |
| Thursday, April 21 |
| » Defeated Browns (1-2), 8-2 | Sportsman's Park III (2-1) | 2-1 | Won 2 |
| » Starters: Steve Gromek vs Dick Starr | Second | 1 out |
| » Major-league debuts: Roy Sievers (Browns) |
| Friday, April 22 |
| » Defeated Tigers (2-2), 4-3 | Cleveland Stadium (1-0) | 3-1 | Won 3 |
| » Starters: Fred Hutchinson vs Gene Bearden | Second | 1 out |
| Saturday, April 23 |
| » Lost to Tigers (3-2), 5-4 | Cleveland Stadium (1-1) | 3-2 | |
| » Starters: Hal Newhouser vs Early Wynn | Third | 1 out |
| Tuesday, April 26 |
| » Defeated Browns (1-7), 1-0 | Cleveland Stadium (2-1) | 4-2 | |
| » Starters: Red Embree vs Bob Lemon | Third | 2 out |
| Future Indian Bruce Ellingsen is born in Pocatello, ID. |
| Wednesday, April 27 |
| » Defeated White Sox (5-5), 11-3 | Cleveland Stadium (3-1) | 5-2 | Won 2 |
| » Starters: Marino Pieretti vs Steve Gromek | Second | 1 out |
| Thursday, April 28 |
| » Major-league debuts: Saul Rogovin (Tigers) |
| Friday, April 29 |
| » Defeated Tigers (5-5), 4-1 | Tiger Stadium (1-0) | 6-2 | Won 3 |
| » Starters: Gene Bearden vs Fred Hutchinson | Second | 1½ out |
| Saturday, April 30 |
| » Lost to Tigers (6-5), 7-5 | Tiger Stadium (1-1) | 6-3 | |
| » Starters: Satchel Paige vs Virgil Trucks | Second | 2½ out |
| » Major-league debuts: Bobby Avila (Indians) |
| Sunday, May 1 |
| » Lost to Tigers (7-5), 3-2 | Tiger Stadium (1-2) | 6-4 | Lost 2 |
| » Starters: Bob Lemon vs Hal Newhouser | Third | 2½ out |
| Wednesday, May 4 |
| » Defeated Athletics (8-8), 4-3 | Cleveland Stadium (4-1) | 7-4 | |
| » Starters: Dick Fowler vs Gene Bearden | Second | 3 out |
| Thursday, May 5 |
| » Defeated Red Sox (6-8), 7-3 | Cleveland Stadium (5-1) | 8-4 | Won 2 |
| » Starters: Jack Kramer vs Bob Feller | Second | 3 out |
| Saturday, May 7 |
| » Defeated Red Sox (6-9), 4-3 | Cleveland Stadium (6-1) | 9-4 | Won 3 |
| » Starters: Mel Parnell vs Bob Lemon | Second | 2½ out |
| Sunday, May 8 |
| » Lost to Senators (9-11), 7-3 | Cleveland Stadium (6-2) | 9-5 | |
| » Starters: Ray Scarborough vs Gene Bearden | Second | 4 out |
| » Lost to Senators (10-11), 2-0 | Cleveland Stadium (6-3) | 9-6 | Lost 2 |
| » Starters: Sid Hudson vs Al Benton | Second | 4 out |
| Tuesday, May 10 |
| » Lost to Senators (11-11), 1-0 | Cleveland Stadium (6-4) | 9-7 | Lost 3 |
| » Starters: Mickey Haefner vs Steve Gromek | Third | 4½ out |
| Wednesday, May 11 |
| » Defeated Yankees (16-6), 3-2 | Cleveland Stadium (7-4) | 10-7 | |
| » Starters: Bob Porterfield vs Bob Lemon | Second | 3½ out |
| Friday, May 13 |
| » Lost to White Sox (12-12), 11-10 | Comiskey Park I (0-1) | 10-8 | |
| » Starters: Early Wynn vs Billy Pierce | Third | 4 out |
| Sunday, May 15 |
| » Lost to White Sox (13-12), 10-0 | Comiskey Park I (0-2) | 10-9 | Lost 2 |
| » Starters: Bob Feller vs Bill Wight | Fifth | 3½ out |
| » Lost to White Sox (14-12), 2-0 | Comiskey Park I (0-3) | 10-10 | Lost 3 |
| » Starters: Steve Gromek vs Al Gettel | Fifth | 3½ out |
| Future Indian Steve Dunning is born in Denver, CO. |
| Tuesday, May 17 |
| » Lost to Yankees (17-9), 4-3 | Yankee Stadium (0-1) | 10-11 | Lost 4 |
| » Starters: Gene Bearden vs Ed Lopat | Sixth | 4½ out |
| Wednesday, May 18 |
| » Lost to Yankees (18-9), 6-0 | Yankee Stadium (0-2) | 10-12 | Lost 5 |
| » Starters: Bob Feller vs Vic Raschi | Sixth | 5½ out |
| Thursday, May 19 |
| » Defeated Yankees (18-10), 3-2 | Yankee Stadium (1-2) | 11-12 | |
| » Starters: Steve Gromek vs Bob Porterfield | Fifth | 4½ out |
| Saturday, May 21 |
| » Lost to Red Sox (13-14), 4-0 | Fenway Park (0-1) | 11-13 | |
| » Starters: Al Benton vs Joe Dobson | Seventh | 5½ out |
| Sunday, May 22 |
| » Lost to Athletics (18-14), 5-4 | Shibe Park (0-1) | 11-14 | Lost 2 |
| » Starters: Gene Bearden vs Alex Kellner | Sixth | 6½ out |
| » Lost to Athletics (19-14), 7-3 | Shibe Park (0-2) | 11-15 | Lost 3 |
| » Starters: Mike Garcia vs Lou Brissie | Sixth | 6½ out |
| Monday, May 23 |
| » Defeated Athletics (19-15), 7-3 | Shibe Park (1-2) | 12-15 | |
| » Starters: Early Wynn vs Bill McCahan | Seventh | 6½ out |
| Wednesday, May 25 |
| » Lost to Senators (18-17), 6-2 | Griffith Stadium (0-1) | 12-16 | |
| » Starters: Steve Gromek vs Sid Hudson | Seventh | 8 out |
| Thursday, May 26 |
| » Lost to Senators (19-17), 5-4 | Griffith Stadium (0-2) | 12-17 | Lost 2 |
| » Starters: Gene Bearden vs Mickey Haefner | Seventh | 8½ out |
| Future Indian Ed Crosby is born in Long Beach, CA. |
| Friday, May 27 |
| » Defeated White Sox (17-17), 4-0 | Cleveland Stadium (8-4) | 13-17 | |
| » Starters: Bill Wight vs Al Benton | Seventh | 8½ out |
| Saturday, May 28 |
| » Defeated White Sox (17-18), 3-2 | Cleveland Stadium (9-4) | 14-17 | Won 2 |
| » Starters: Howie Judson vs Early Wynn | Seventh | 8½ out |
| Sunday, May 29 |
| » Lost to White Sox (18-18), 4-2 | Cleveland Stadium (9-5) | 14-18 | |
| » Starters: Randy Gumpert vs Steve Gromek | Seventh | 8 out |
| » Defeated White Sox (18-19), 2-1 | Cleveland Stadium (10-5) | 15-18 | |
| » Starters: Billy Pierce vs Satchel Paige | Seventh | 8 out |
| Monday, May 30 |
| » Defeated Browns (10-29), 2-1 | Cleveland Stadium (11-5) | 16-18 | Won 2 |
| » Starters: Ned Garver vs Gene Bearden | Sixth | 7 out |
| » Defeated Browns (10-30), 5-0 | Cleveland Stadium (12-5) | 17-18 | Won 3 |
| » Starters: Cliff Fannin vs Mike Garcia | Sixth | 7 out |
| Wednesday, June 1 |
| » Lost to Red Sox (21-16), 3-1 | Cleveland Stadium (12-6) | 17-19 | |
| » Starters: Mickey Harris vs Bob Feller | Seventh | 8 out |
| Thursday, June 2 |
| » Defeated Red Sox (21-17), 8-3 | Cleveland Stadium (13-6) | 18-19 | |
| » Starters: Ellis Kinder vs Bob Lemon | Sixth | 8 out |
| Friday, June 3 |
| » Defeated Red Sox (21-18), 8-1 | Cleveland Stadium (14-6) | 19-19 | Won 2 |
| » Starters: Joe Dobson vs Early Wynn | Fifth | 8 out |
| Saturday, June 4 |
| » Lost to Athletics (22-22), 10-3 | Cleveland Stadium (14-7) | 19-20 | |
| » Starters: Dick Fowler vs Gene Bearden | Sixth | 9 out |
| Sunday, June 5 |
| » Lost to Athletics (23-22), 3-0 | Cleveland Stadium (14-8) | 19-21 | Lost 2 |
| » Starters: Bill McCahan vs Bob Feller | Seventh | 10 out |
| » Lost to Athletics (24-22), 4-2 | Cleveland Stadium (14-9) | 19-22 | Lost 3 |
| » Starters: Carl Scheib vs Satchel Paige | Seventh | 10 out |
| Monday, June 6 |
| » Defeated Athletics (24-23), 11-5 | Cleveland Stadium (15-9) | 20-22 | |
| » Starters: Joe Coleman vs Steve Gromek | Fifth | 9½ out |
| Tuesday, June 7 |
| » Defeated Senators (25-22), 13-11 | Cleveland Stadium (16-9) | 21-22 | Won 2 |
| » Starters: Mickey Haefner vs Bob Lemon | Sixth | 8½ out |
| Wednesday, June 8 |
| » Defeated Senators (25-23), 8-3 | Cleveland Stadium (17-9) | 22-22 | Won 3 |
| » Starters: Paul Calvert vs Bob Lemon | Sixth | 7½ out |
| Friday, June 10 |
| » Lost to Yankees (31-16), 3-2 | Cleveland Stadium (17-10) | 22-23 | |
| » Starters: Vic Raschi vs Gene Bearden | Fifth | 8 out |
| Saturday, June 11 |
| » Lost to Yankees (32-16), 12-7 | Cleveland Stadium (17-11) | 22-24 | Lost 2 |
| » Starters: Allie Reynolds vs Bob Feller | Sixth | 9 out |
| Sunday, June 12 |
| » Defeated Yankees (32-17), 6-0 | Cleveland Stadium (18-11) | 23-24 | |
| » Starters: Ed Lopat vs Bob Lemon | Sixth | 7 out |
| » Defeated Yankees (32-18), 3-1 | Cleveland Stadium (19-11) | 24-24 | Won 2 |
| » Starters: Tommy Byrne vs Mike Garcia | Sixth | 7 out |
| Tuesday, June 14 |
| » Defeated Red Sox (25-25), 10-5 | Fenway Park (1-1) | 25-24 | Won 3 |
| » Starters: Bob Feller vs Joe Dobson | Fourth | 7 out |
| Wednesday, June 15 |
| » Defeated Red Sox (25-26), 8-5 | Fenway Park (2-1) | 26-24 | Won 4 |
| » Starters: Gene Bearden vs Walt Masterson | Fourth | 7 out |
| Former Indian Nig Clarke dies in River Rouge, MI at the age of 67. |
| Thursday, June 16 |
| » Defeated Red Sox (25-27), 6-3 | Fenway Park (3-1) | 27-24 | Won 5 |
| » Starters: Mike Garcia vs Mel Parnell | Fourth | 6½ out |
| Friday, June 17 |
| » Defeated Yankees (35-20), 10-4 | Yankee Stadium (2-2) | 28-24 | Won 6 |
| » Starters: Bob Lemon vs Ed Lopat | Fourth | 5½ out |
| Saturday, June 18 |
| » Lost to Yankees (36-20), 6-3 | Yankee Stadium (2-3) | 28-25 | |
| » Starters: Satchel Paige vs Vic Raschi | Fourth | 6½ out |
| Sunday, June 19 |
| » Defeated Yankees (36-21), 4-2 | Yankee Stadium (3-3) | 29-25 | |
| » Starters: Bob Feller vs Allie Reynolds | Fourth | 5½ out |
| Monday, June 20 |
| » Lost to Athletics (33-26), 4-1 | Shibe Park (1-3) | 29-26 | |
| » Starters: Mike Garcia vs Dick Fowler | Fourth | 6½ out |
| Tuesday, June 21 |
| » Lost to Athletics (34-26), 8-2 | Shibe Park (1-4) | 29-27 | Lost 2 |
| » Starters: Bob Lemon vs Lou Brissie | Fifth | 7 out |
| Wednesday, June 22 |
| » Defeated Athletics (34-27), 7-3 | Shibe Park (2-4) | 30-27 | |
| » Starters: Gene Bearden vs Joe Coleman | Fourth | 6½ out |
| Thursday, June 23 |
| » Defeated Senators (29-31), 4-3 | Griffith Stadium (1-2) | 31-27 | Won 2 |
| » Starters: Early Wynn vs Paul Calvert | Fourth | 6½ out |
| Friday, June 24 |
| » Defeated Senators (29-32), 8-2 | Griffith Stadium (2-2) | 32-27 | Won 3 |
| » Starters: Bob Feller vs Joe Haynes | Fourth | 6½ out |
| Saturday, June 25 |
| » Lost to Senators (30-32), 4-2 | Griffith Stadium (2-3) | 32-28 | |
| » Starters: Frank Papish vs Mickey Harris | Fifth | 6½ out |
| Sunday, June 26 |
| » Defeated Senators (30-33), 3-1 | Griffith Stadium (3-3) | 33-28 | |
| » Starters: Steve Gromek vs Sid Hudson | Fifth | 6 out |
| Tuesday, June 28 |
| » Defeated Tigers (36-30), 4-2 | Cleveland Stadium (20-11) | 34-28 | Won 2 |
| » Starters: Virgil Trucks vs Bob Lemon | Third | 6 out |
| Wednesday, June 29 |
| » Lost to Tigers (37-30), 4-0 | Cleveland Stadium (20-12) | 34-29 | |
| » Starters: Hal Newhouser vs Gene Bearden | Third | 6½ out |
| » Defeated Tigers (37-31), 8-7 | Cleveland Stadium (21-12) | 35-29 | |
| » Starters: Ted Gray vs Bob Feller | Third | 6½ out |
| Thursday, June 30 |
| » Lost to Tigers (38-31), 12-6 | Cleveland Stadium (21-13) | 35-30 | |
| » Starters: Art Houtteman vs Early Wynn | Fourth | 7½ out |
| Friday, July 1 |
| » Defeated Browns (20-47), 3-1 | Cleveland Stadium (22-13) | 36-30 | |
| » Starters: Joe Ostrowski vs Al Benton | Third | 7½ out |
| Saturday, July 2 |
| » Lost to Browns (21-47), 4-2 | Cleveland Stadium (22-14) | 36-31 | |
| » Starters: Karl Drews vs Bob Lemon | Fourth | 8½ out |
| Sunday, July 3 |
| » Defeated Browns (21-48), 4-3 | Cleveland Stadium (23-14) | 37-31 | |
| » Starters: Bill Kennedy vs Early Wynn | Third | 7 out |
| » Defeated Browns (21-49), 4-3 | Cleveland Stadium (24-14) | 38-31 | Won 2 |
| » Starters: Cliff Fannin vs Steve Gromek | Third | 7 out |
| Monday, July 4 |
| » Defeated Tigers (39-34), 3-2 | Tiger Stadium (2-2) | 39-31 | Won 3 |
| » Starters: Bob Feller vs Art Houtteman | Third | 7 out |
| » Defeated Tigers (39-35), 7-3 | Tiger Stadium (3-2) | 40-31 | Won 4 |
| » Starters: Gene Bearden vs Hal Newhouser | Third | 7 out |
| Tuesday, July 5 |
| » Defeated Tigers (39-36), 8-1 | Tiger Stadium (4-2) | 41-31 | Won 5 |
| » Starters: Frank Papish vs Marv Grissom | Third | 6 out |
| Wednesday, July 6 |
| » Lost to White Sox (31-45), 9-6 | Comiskey Park I (0-4) | 41-32 | |
| » Starters: Steve Gromek vs Bob Kuzava | Third | 6½ out |
| Thursday, July 7 |
| » Defeated White Sox (31-46), 8-2 | Comiskey Park I (1-4) | 42-32 | |
| » Starters: Bob Lemon vs Marino Pieretti | Third | 6½ out |
| Friday, July 8 |
| » Defeated Browns (24-52), 6-5 | Sportsman's Park III (3-1) | 43-32 | Won 2 |
| » Starters: Early Wynn vs Cliff Fannin | Third | 6½ out |
| Sunday, July 10 |
| » Defeated Browns (24-53), 7-4 | Sportsman's Park III (4-1) | 44-32 | Won 3 |
| » Starters: Bob Feller vs Ned Garver | Second | 5½ out |
| Monday, July 11 |
| Future Indian Jack Heidemann is born in Brenham, TX. Future Indian Stan Thomas is born in Rumford, ME. |
| Thursday, July 14 |
| » Defeated Athletics (44-36), 7-1 | Cleveland Stadium (25-14) | 45-32 | Won 4 |
| » Starters: Alex Kellner vs Bob Lemon | Second | 5½ out |
| Friday, July 15 |
| » Lost to Athletics (45-36), 8-0 | Cleveland Stadium (25-15) | 45-33 | |
| » Starters: Dick Fowler vs Bob Feller | Second | 6½ out |
| Saturday, July 16 |
| » Defeated Athletics (45-37), 7-3 | Cleveland Stadium (26-15) | 46-33 | |
| » Starters: Lou Brissie vs Steve Gromek | Second | 5½ out |
| Sunday, July 17 |
| » Defeated Red Sox (43-38), 4-2 | Cleveland Stadium (27-15) | 47-33 | Won 2 |
| » Starters: Jack Kramer vs Early Wynn | Second | 5½ out |
| » Lost to Red Sox (44-38), 2-1 | Cleveland Stadium (27-16) | 47-34 | |
| » Starters: Chuck Stobbs vs Al Benton | Second | 5½ out |
| Former Indian Jack Slattery dies in Boston, MA at the age of 72. |
| Monday, July 18 |
| » Defeated Red Sox (44-39), 1-0 | Cleveland Stadium (28-16) | 48-34 | |
| » Starters: Mickey McDermott vs Mike Garcia | Second | 4½ out |
| Tuesday, July 19 |
| » Defeated Yankees (53-31), 5-4 | Cleveland Stadium (29-16) | 49-34 | Won 2 |
| » Starters: Allie Reynolds vs Bob Lemon | Second | 3½ out |
| » Major-league debuts: Duane Pillette (Yankees) |
| Wednesday, July 20 |
| » Lost to Yankees (54-31), 7-3 | Cleveland Stadium (29-17) | 49-35 | |
| » Starters: Ed Lopat vs Bob Feller | Second | 4½ out |
| Thursday, July 21 |
| » Lost to Yankees (55-31), 5-3 | Cleveland Stadium (29-18) | 49-36 | Lost 2 |
| » Starters: Vic Raschi vs Early Wynn | Second | 5½ out |
| Friday, July 22 |
| » Defeated Senators (34-49), 2-1 | Cleveland Stadium (30-18) | 50-36 | |
| » Starters: Paul Calvert vs Mike Garcia | Second | 5½ out |
| Saturday, July 23 |
| » Defeated Senators (34-50), 5-3 | Cleveland Stadium (31-18) | 51-36 | Won 2 |
| » Starters: Joe Haynes vs Bob Feller | Second | 4½ out |
| Sunday, July 24 |
| » Defeated Senators (34-51), 7-5 | Cleveland Stadium (32-18) | 52-36 | Won 3 |
| » Starters: Al Gettel vs Bob Lemon | Second | 4 out |
| » Defeated Senators (34-52), 5-2 | Cleveland Stadium (33-18) | 53-36 | Won 4 |
| » Starters: Mickey Harris vs Gene Bearden | Second | 4 out |
| Monday, July 25 |
| » Defeated Yankees (57-33), 4-2 | Yankee Stadium (4-3) | 54-36 | Won 5 |
| » Starters: Early Wynn vs Vic Raschi | Second | 3 out |
| Thursday, July 28 |
| » Lost to Yankees (58-33), 3-2 | Yankee Stadium (4-4) | 54-37 | |
| » Starters: Bob Lemon vs Allie Reynolds | Second | 4 out |
| Friday, July 29 |
| » Lost to Red Sox (52-41), 2-1 | Fenway Park (3-2) | 54-38 | Lost 2 |
| » Starters: Mike Garcia vs Joe Dobson | Second | 4½ out |
| » Defeated Red Sox (52-42), 9-3 | Fenway Park (4-2) | 55-38 | |
| » Starters: Gene Bearden vs Chuck Stobbs | Second | 4½ out |
| Saturday, July 30 |
| » Defeated Red Sox (52-43), 10-6 | Fenway Park (5-2) | 56-38 | Won 2 |
| » Starters: Early Wynn vs Jack Kramer | Second | 3½ out |
| Sunday, July 31 |
| » Lost to Red Sox (53-43), 3-0 | Fenway Park (5-3) | 56-39 | |
| » Starters: Gene Bearden vs Mickey McDermott | Second | 4 out |
| Monday, August 1 |
| » Lost to Red Sox (54-43), 4-3 | Fenway Park (5-4) | 56-40 | Lost 2 |
| » Starters: Bob Lemon vs Mel Parnell | Second | 4½ out |
| Tuesday, August 2 |
| » Defeated Senators (36-59), 8-1 | Griffith Stadium (4-3) | 57-40 | |
| » Starters: Early Wynn vs Mickey Harris | Second | 3½ out |
| Thursday, August 4 |
| » Defeated Senators (36-60), 6-3 | Griffith Stadium (5-3) | 58-40 | Won 2 |
| » Starters: Frank Papish vs Dick Weik | Second | 2½ out |
| » Defeated Senators (36-61), 14-1 | Griffith Stadium (6-3) | 59-40 | Won 3 |
| » Starters: Bob Feller vs Paul Calvert | Second | 2½ out |
| Friday, August 5 |
| » Defeated Athletics (55-47), 3-2 | Shibe Park (3-4) | 60-40 | Won 4 |
| » Starters: Mike Garcia vs Alex Kellner | Second | 3 out |
| Saturday, August 6 |
| » Lost to Athletics (56-47), 2-0 | Shibe Park (3-5) | 60-41 | |
| » Starters: Bob Lemon vs Dick Fowler | Second | 4 out |
| Sunday, August 7 |
| » Lost to Athletics (57-47), 5-4 | Shibe Park (3-6) | 60-42 | Lost 2 |
| » Starters: Early Wynn vs Lou Brissie | Second | 5½ out |
| » Lost to Athletics (58-47), 4-2 | Shibe Park (3-7) | 60-43 | Lost 3 |
| » Starters: Al Benton vs Joe Coleman | Second | 5½ out |
| Tuesday, August 9 |
| » Defeated Browns (34-71), 9-2 | Cleveland Stadium (34-18) | 61-43 | |
| » Starters: Ned Garver vs Bob Feller | Second | 4½ out |
| Wednesday, August 10 |
| » Lost to Browns (35-71), 5-4 | Cleveland Stadium (34-19) | 61-44 | |
| » Starters: Cliff Fannin vs Bob Lemon | Second | 5½ out |
| Thursday, August 11 |
| » Defeated White Sox (45-62), 6-5 | Cleveland Stadium (35-19) | 62-44 | |
| » Starters: Bob Kuzava vs Mike Garcia | Second | 4½ out |
| » Major-league debuts: Luke Easter (Indians) |
| Friday, August 12 |
| » Lost to White Sox (46-62), 6-5 | Cleveland Stadium (35-20) | 62-45 | |
| » Starters: Randy Gumpert vs Early Wynn | Third | 5½ out |
| Saturday, August 13 |
| Future Indian Andre Thornton is born in Tuskegee, AL. |
| Sunday, August 14 |
| » Defeated White Sox (46-63), 4-3 | Cleveland Stadium (36-20) | 63-45 | |
| » Starters: Mickey Haefner vs Bob Lemon | Third | 5 out |
| » Defeated White Sox (46-64), 5-0 | Cleveland Stadium (37-20) | 64-45 | Won 2 |
| » Starters: Billy Pierce vs Mike Garcia | Third | 5 out |
| Monday, August 15 |
| » Defeated Tigers (62-51), 4-3 | Cleveland Stadium (38-20) | 65-45 | Won 3 |
| » Starters: Hal Newhouser vs Bob Feller | Third | 4 out |
| Tuesday, August 16 |
| » Defeated Tigers (62-52), 5-0 | Cleveland Stadium (39-20) | 66-45 | Won 4 |
| » Starters: Virgil Trucks vs Al Benton | Second | 3½ out |
| Wednesday, August 17 |
| » Lost to Browns (36-77), 10-6 | Sportsman's Park III (4-2) | 66-46 | |
| » Starters: Early Wynn vs Al Papai | Third | 5 out |
| » Lost to Browns (37-77), 5-2 | Sportsman's Park III (4-3) | 66-47 | Lost 2 |
| » Starters: Satchel Paige vs Bill Kennedy | Third | 5 out |
| Thursday, August 18 |
| » Defeated Browns (37-78), 14-4 | Sportsman's Park III (5-3) | 67-47 | |
| » Starters: Bob Lemon vs Karl Drews | Third | 5 out |
| Friday, August 19 |
| » Defeated White Sox (49-66), 2-0 | Comiskey Park I (2-4) | 68-47 | Won 2 |
| » Starters: Mike Garcia vs Randy Gumpert | Third | 5 out |
| Sunday, August 21 |
| » Lost to White Sox (50-66), 5-4 | Comiskey Park I (2-5) | 68-48 | |
| » Starters: Bob Feller vs Bill Wight | Third | 5 out |
| » Defeated White Sox (50-67), 7-4 | Comiskey Park I (3-5) | 69-48 | |
| » Starters: Early Wynn vs Bob Kuzava | Third | 5 out |
| Tuesday, August 23 |
| » Lost to Senators (39-77), 4-2 | Cleveland Stadium (39-21) | 69-49 | |
| » Starters: Ray Scarborough vs Bob Lemon | Third | 5 out |
| Wednesday, August 24 |
| » Lost to Senators (40-77), 3-2 | Cleveland Stadium (39-22) | 69-50 | Lost 2 |
| » Starters: Mickey Harris vs Mike Garcia | Third | 5 out |
| Thursday, August 25 |
| » Lost to Yankees (74-44), 6-3 | Cleveland Stadium (39-23) | 69-51 | Lost 3 |
| » Starters: Ed Lopat vs Bob Feller | Third | 6 out |
| Friday, August 26 |
| » Defeated Yankees (74-45), 5-3 | Cleveland Stadium (40-23) | 70-51 | |
| » Starters: Vic Raschi vs Al Benton | Third | 5 out |
| Saturday, August 27 |
| » Lost to Yankees (75-45), 4-0 | Cleveland Stadium (40-24) | 70-52 | |
| » Starters: Tommy Byrne vs Early Wynn | Third | 6 out |
| Sunday, August 28 |
| » Defeated Red Sox (75-49), 2-1 | Cleveland Stadium (41-24) | 71-52 | |
| » Starters: Jack Kramer vs Bob Lemon | Third | 6½ out |
| Monday, August 29 |
| » Defeated Red Sox (75-50), 5-2 | Cleveland Stadium (42-24) | 72-52 | Won 2 |
| » Starters: Earl Johnson vs Bob Feller | Third | 5½ out |
| » Defeated Red Sox (75-51), 5-4 | Cleveland Stadium (43-24) | 73-52 | Won 3 |
| » Starters: Joe Dobson vs Mike Garcia | Third | 5½ out |
| Wednesday, August 31 |
| » Defeated Athletics (66-59), 7-6 | Cleveland Stadium (44-24) | 74-52 | Won 4 |
| » Starters: Dick Fowler vs Gene Bearden | Third | 4½ out |
| » Lost to Athletics (67-59), 2-1 | Cleveland Stadium (44-25) | 74-53 | |
| » Starters: Lou Brissie vs Early Wynn | Third | 4½ out |
| Thursday, September 1 |
| » Defeated Athletics (67-60), 2-1 | Cleveland Stadium (45-25) | 75-53 | |
| » Starters: Carl Scheib vs Bob Lemon | Third | 4½ out |
| Saturday, September 3 |
| » Lost to Browns (48-83), 4-3 | Cleveland Stadium (45-26) | 75-54 | |
| » Starters: Cliff Fannin vs Bob Feller | Third | 5½ out |
| Sunday, September 4 |
| » Defeated Browns (48-84), 5-0 | Cleveland Stadium (46-26) | 76-54 | |
| » Starters: Ned Garver vs Mike Garcia | Third | 4½ out |
| Monday, September 5 |
| » Defeated White Sox (53-79), 5-3 | Cleveland Stadium (47-26) | 77-54 | Won 2 |
| » Starters: Randy Gumpert vs Al Benton | Third | 4½ out |
| » Defeated White Sox (53-80), 6-4 | Cleveland Stadium (48-26) | 78-54 | Won 3 |
| » Starters: Mickey Haefner vs Bob Lemon | Third | 4½ out |
| Thursday, September 8 |
| » Lost to Tigers (79-58), 10-0 | Tiger Stadium (4-3) | 78-55 | |
| » Starters: Early Wynn vs Hal Newhouser | Third | 6 out |
| » Lost to Tigers (80-58), 4-1 | Tiger Stadium (4-4) | 78-56 | Lost 2 |
| » Starters: Bob Feller vs Ted Gray | Third | 6 out |
| Friday, September 9 |
| » Defeated Browns (48-89), 5-2 | Sportsman's Park III (6-3) | 79-56 | |
| » Starters: Mike Garcia vs Al Papai | Third | 5 out |
| Saturday, September 10 |
| » Defeated Browns (48-90), 2-1 | Sportsman's Park III (7-3) | 80-56 | Won 2 |
| » Starters: Bob Lemon vs Bill Kennedy | Third | 4½ out |
| Sunday, September 11 |
| » Lost to Browns (49-90), 5-4 | Sportsman's Park III (7-4) | 80-57 | |
| » Starters: Al Benton vs Cliff Fannin | Fourth | 6 out |
| Monday, September 12 |
| Former Indian Sherry Smith dies in Reidsville, GA at the age of 59. |
| Tuesday, September 13 |
| Future Indian Rick Dempsey is born in Fayetteville, TN. |
| Wednesday, September 14 |
| » Lost to Athletics (73-66), 2-1 | Shibe Park (3-8) | 80-58 | Lost 2 |
| » Starters: Bob Feller vs Bobby Shantz | Third | 7½ out |
| Thursday, September 15 |
| » Defeated Yankees (87-51), 10-6 | Yankee Stadium (5-4) | 81-58 | |
| » Starters: Bob Lemon vs Allie Reynolds | Third | 6½ out |
| Friday, September 16 |
| » Lost to Senators (45-95), 5-4 | Griffith Stadium (6-4) | 81-59 | |
| » Starters: Mike Garcia vs Ray Scarborough | Third | 7½ out |
| Saturday, September 17 |
| » Defeated Senators (45-96), 8-3 | Griffith Stadium (7-4) | 82-59 | |
| » Starters: Gene Bearden vs Mickey Harris | Third | 7½ out |
| Sunday, September 18 |
| » Lost to Yankees (90-51), 7-3 | Yankee Stadium (5-5) | 82-60 | |
| » Starters: Al Benton vs Vic Raschi | Third | 8½ out |
| Monday, September 19 |
| » Lost to Yankees (91-51), 6-0 | Yankee Stadium (5-6) | 82-61 | Lost 2 |
| » Starters: Bob Feller vs Ed Lopat | Fourth | 9½ out |
| Tuesday, September 20 |
| » Lost to Red Sox (90-55), 5-2 | Fenway Park (5-5) | 82-62 | Lost 3 |
| » Starters: Bob Lemon vs Mel Parnell | Fourth | 10½ out |
| Wednesday, September 21 |
| » Lost to Red Sox (91-55), 9-6 | Fenway Park (5-6) | 82-63 | Lost 4 |
| » Starters: Mike Garcia vs Jack Kramer | Fourth | 10½ out |
| Thursday, September 22 |
| » Major-league debuts: Steve Bilko (Cardinals) |
| Friday, September 23 |
| » Lost to Tigers (86-63), 5-0 | Cleveland Stadium (48-27) | 82-64 | Lost 5 |
| » Starters: Virgil Trucks vs Early Wynn | Fourth | 11 out |
| Saturday, September 24 |
| » Lost to Tigers (87-63), 8-5 | Cleveland Stadium (48-28) | 82-65 | Lost 6 |
| » Starters: Hal Newhouser vs Bob Feller | Fourth | 11 out |
| Sunday, September 25 |
| » Defeated Tigers (87-64), 7-1 | Cleveland Stadium (49-28) | 83-65 | |
| » Starters: Art Houtteman vs Bob Lemon | Third | 10 out |
| Tuesday, September 27 |
| » Defeated White Sox (62-87), 3-2 | Comiskey Park I (4-5) | 84-65 | Won 2 |
| » Starters: Mike Garcia vs Mickey Haefner | Fourth | 10½ out |
| Wednesday, September 28 |
| » Defeated White Sox (62-88), 4-2 | Comiskey Park I (5-5) | 85-65 | Won 3 |
| » Starters: Bob Lemon vs Jack Bruner | Third | 9½ out |
| Thursday, September 29 |
| » Defeated White Sox (62-89), 8-3 | Comiskey Park I (6-5) | 86-65 | Won 4 |
| » Starters: Early Wynn vs Bob Kuzava | Third | 9 out |
| Friday, September 30 |
| » Defeated Tigers (87-65), 6-4 | Tiger Stadium (5-4) | 87-65 | Won 5 |
| » Starters: Bob Feller vs Hal Newhouser | Third | 9 out |
| Saturday, October 1 |
| » Defeated Tigers (87-66), 4-0 | Tiger Stadium (6-4) | 88-65 | Won 6 |
| » Starters: Mike Garcia vs Ted Gray | Second | 8 out |
| Sunday, October 2 |
| » Defeated Tigers (87-67), 8-4 | Tiger Stadium (7-4) | 89-65 | Won 7 |
| » Starters: Bob Lemon vs Virgil Trucks | Third | 8 out |
| Sunday, October 16 |
| Future Indian Don Hood is born in Florence, SC. Former Indian Jack Ryan dies in Handsboro, MS at the age of 66 |
| Tuesday, October 18 |
| Future Indian Ed Farmer is born in Evergreen Park, IL. Future Indian George Hendrick is born in Los Angeles, CA. |
| Wednesday, October 26 |
| Future Indian Mike Hargrove is born in Perryton, TX. |
| Monday, November 28 |
| Former Indian Art Kruger dies in Hondo, CA at the age of 69. |
| Tuesday, December 20 |
| Future Indian Oscar Gamble is born in Ramer, AL. |
Game information provided by Retros |
