| Sunday, January 9 |
| Former Cub Harry McIntire dies in Daytona Beach, FL at the age of 70. |
| Saturday, January 29 |
| Future Cub Jim Tyrone is born in Alice, TX. |
| Thursday, February 10 |
| Former Cub Johnny Bates dies in Steubenville, OH at the age of 67. |
| Saturday, February 12 |
| Future Cub Lenny Randle is born in Long Beach, CA. |
| Wednesday, February 16 |
| Former Cub Tommy Raub dies in Phillipsburg, NJ at the age of 79. |
| Friday, February 18 |
| Future Cub Jerry Morales is born in Yabucoa, P.R. |
| Sunday, April 10 |
| Future Cub Tom Lundstedt is born in Davenport, IA. |
| Tuesday, April 19 |
| » Lost to Pirates (1-0), 1-0 | Wrigley Field (0-1) | 0-1 | |
| » Starters: Rip Sewell vs Dutch Leonard | Fourth | 1 out |
| » Major-league debuts: Smoky Burgess (Cubs) |
| Wednesday, April 20 |
| » Defeated Pirates (1-1), 4-0 | Wrigley Field (1-1) | 1-1 | |
| » Starters: Murry Dickson vs Bob Rush | Fourth | 1 out |
| Thursday, April 21 |
| » Defeated Pirates (1-2), 4-3 | Wrigley Field (2-1) | 2-1 | Won 2 |
| » Starters: Bob Muncrief vs Monk Dubiel | Third | ½ out |
| Friday, April 22 |
| » Lost to Cardinals (1-2), 9-2 | Sportsman's Park III (0-1) | 2-2 | |
| » Starters: Johnny Schmitz vs Al Brazle | Third | 1 out |
| Saturday, April 23 |
| » Defeated Cardinals (1-3), 11-7 | Sportsman's Park III (1-1) | 3-2 | |
| » Starters: Dewey Adkins vs Red Munger | Third | ½ out |
| » Major-league debuts: Cloyd Boyer and Bill Reeder (Cardinals) |
| Sunday, April 24 |
| » Lost to Cardinals (2-3), 5-4 | Sportsman's Park III (1-2) | 3-3 | |
| » Starters: Lefty Sloat vs Jim Hearn | Third | 1 out |
| Monday, April 25 |
| » Lost to Pirates (4-3), 8-2 | Forbes Field (0-1) | 3-4 | Lost 2 |
| » Starters: Bob Rush vs Rip Sewell | Fourth | 1½ out |
| Wednesday, April 27 |
| » Defeated Reds (3-4), 8-3 | Wrigley Field (3-1) | 4-4 | |
| » Starters: Johnny Vander Meer vs Dutch Leonard | Third | 1 out |
| Thursday, April 28 |
| » Lost to Reds (4-4), 2-0 | Wrigley Field (3-2) | 4-5 | |
| » Starters: Ken Raffensberger vs Monk Dubiel | Fourth | 1½ out |
| Friday, April 29 |
| » Defeated Cardinals (4-5), 5-4 | Wrigley Field (4-2) | 5-5 | |
| » Starters: Red Munger vs Johnny Schmitz | Fourth | 1 out |
| Saturday, April 30 |
| » Lost to Cardinals (5-5), 4-3 | Wrigley Field (4-3) | 5-6 | |
| » Starters: Cloyd Boyer vs Bob Rush | Sixth | 1½ out |
| Sunday, May 1 |
| » Lost to Cardinals (6-5), 8-3 | Wrigley Field (4-4) | 5-7 | Lost 2 |
| » Starters: Harry Brecheen vs Dutch Leonard | Sixth | 3 out |
| Tuesday, May 3 |
| » Defeated Braves (9-6), 4-0 | Braves Field (1-0) | 6-7 | |
| » Starters: Monk Dubiel vs Vern Bickford | Sixth | 2 out |
| Wednesday, May 4 |
| » Lost to Braves (10-6), 4-3 | Braves Field (1-1) | 6-8 | |
| » Starters: Dutch Leonard vs Johnny Sain | Sixth | 3 out |
| Friday, May 6 |
| » Defeated Dodgers (9-8), 4-2 | Ebbets Field (1-0) | 7-8 | |
| » Starters: Johnny Schmitz vs Rex Barney | Fifth | 3 out |
| Saturday, May 7 |
| » Lost to Dodgers (10-8), 10-4 | Ebbets Field (1-1) | 7-9 | |
| » Starters: Bob Rush vs Ralph Branca | Fifth | 3 out |
| Sunday, May 8 |
| » Lost to Giants (12-7), 10-1 | Polo Grounds V (0-1) | 7-10 | Lost 2 |
| » Starters: Monk Dubiel vs Larry Jansen | Seventh | 4 out |
| Monday, May 9 |
| » Lost to Giants (13-7), 7-2 | Polo Grounds V (0-2) | 7-11 | Lost 3 |
| » Starters: Ralph Hamner vs Sheldon Jones | Eighth | 5 out |
| Wednesday, May 11 |
| » Defeated Phillies (10-12), 4-2 | Shibe Park (1-0) | 8-11 | |
| » Starters: Johnny Schmitz vs Ken Heintzelman | Sixth | 4 out |
| Future Cub Jerry Martin is born in Columbia, SC. |
| Thursday, May 12 |
| » Lost to Phillies (11-12), 4-3 | Shibe Park (1-1) | 8-12 | |
| » Starters: Bob Rush vs Hank Borowy | Seventh | 4 out |
| Friday, May 13 |
| » Lost to Reds (12-10), 7-0 | Crosley Field (0-1) | 8-13 | Lost 2 |
| » Starters: Monk Dubiel vs Buddy Lively | Sixth | 5 out |
| Future Cub Terry Hughes is born in Spartanburg, SC. |
| Saturday, May 14 |
| » Defeated Reds (12-11), 13-1 | Crosley Field (1-1) | 9-13 | |
| » Starters: Dutch Leonard vs Johnny Vander Meer | Sixth | 5 out |
| Sunday, May 15 |
| » Lost to Reds (13-11), 6-5 | Crosley Field (1-2) | 9-14 | |
| » Starters: Johnny Schmitz vs Howie Fox | Sixth | 5½ out |
| » Defeated Reds (13-12), 8-5 | Crosley Field (2-2) | 10-14 | |
| » Starters: Cal McLish vs Herm Wehmeier | Sixth | 5½ out |
| Monday, May 16 |
| Future Cub Rick Reuschel is born in Quincy, IL. |
| Tuesday, May 17 |
| » Lost to Dodgers (13-13), 8-5 | Wrigley Field (4-5) | 10-15 | |
| » Starters: Ralph Branca vs Monk Dubiel | Sixth | 5½ out |
| Wednesday, May 18 |
| » Lost to Dodgers (14-13), 14-5 | Wrigley Field (4-6) | 10-16 | Lost 2 |
| » Starters: Joe Hatten vs Bob Rush | Sixth | 5½ out |
| Saturday, May 21 |
| » Lost to Phillies (14-15), 5-1 | Wrigley Field (4-7) | 10-17 | Lost 3 |
| » Starters: Hank Borowy vs Dutch Leonard | Eighth | 7 out |
| Sunday, May 22 |
| » Lost to Braves (19-12), 7-2 | Wrigley Field (4-8) | 10-18 | Lost 4 |
| » Starters: Johnny Sain vs Johnny Schmitz | Seventh | 7½ out |
| Monday, May 23 |
| » Lost to Braves (20-12), 11-4 | Wrigley Field (4-9) | 10-19 | Lost 5 |
| » Starters: Vern Bickford vs Monk Dubiel | Eighth | 8½ out |
| Tuesday, May 24 |
| » Defeated Giants (19-13), 8-2 | Wrigley Field (5-9) | 11-19 | |
| » Starters: Sheldon Jones vs Bob Chipman | Eighth | 7½ out |
| Wednesday, May 25 |
| » Defeated Giants (19-14), 3-2 | Wrigley Field (6-9) | 12-19 | Won 2 |
| » Starters: Monte Kennedy vs Bob Rush | Eighth | 6½ out |
| Friday, May 27 |
| » Defeated Reds (18-16), 3-1 | Wrigley Field (7-9) | 13-19 | Won 3 |
| » Starters: Howie Fox vs Johnny Schmitz | Fifth | 5½ out |
| Saturday, May 28 |
| » Lost to Reds (19-16), 2-0 | Wrigley Field (7-10) | 13-20 | |
| » Starters: Ken Raffensberger vs Dutch Leonard | Fifth | 6½ out |
| Sunday, May 29 |
| » Lost to Reds (20-16), 4-1 | Wrigley Field (7-11) | 13-21 | Lost 2 |
| » Starters: Eddie Erautt vs Bob Chipman | Fifth | 6 out |
| » Defeated Reds (20-17), 10-2 | Wrigley Field (8-11) | 14-21 | |
| » Starters: Herm Wehmeier vs Monk Dubiel | Fifth | 6 out |
| Monday, May 30 |
| » Defeated Pirates (15-24), 8-5 | Forbes Field (1-1) | 15-21 | Won 2 |
| » Starters: Bob Rush vs Rip Sewell | Fifth | 6 out |
| » Lost to Pirates (16-24), 8-6 | Forbes Field (1-2) | 15-22 | |
| » Starters: Cal McLish vs Bob Chesnes | Fifth | 6 out |
| Wednesday, June 1 |
| » Lost to Giants (23-18), 11-5 | Polo Grounds V (0-3) | 15-23 | Lost 2 |
| » Starters: Johnny Schmitz vs Andy Hansen | Sixth | 7½ out |
| Thursday, June 2 |
| » Defeated Giants (23-19), 3-0 | Polo Grounds V (1-3) | 16-23 | |
| » Starters: Dutch Leonard vs Sheldon Jones | Fifth | 7½ out |
| Friday, June 3 |
| » Lost to Giants (24-19), 15-5 | Polo Grounds V (1-4) | 16-24 | |
| » Starters: Bob Chipman vs Monte Kennedy | Fifth | 8 out |
| Saturday, June 4 |
| » Lost to Phillies (22-22), 1-0 | Shibe Park (1-2) | 16-25 | Lost 2 |
| » Starters: Bob Rush vs Ken Heintzelman | Sixth | 8 out |
| Sunday, June 5 |
| » Lost to Phillies (23-22), 7-2 | Shibe Park (1-3) | 16-26 | Lost 3 |
| » Starters: Johnny Schmitz vs Hank Borowy | Seventh | 8 out |
| » Defeated Phillies (23-23), 8-7 | Shibe Park (2-3) | 17-26 | |
| » Starters: Doyle Lade vs Blix Donnelly | Seventh | 8 out |
| Tuesday, June 7 |
| » Lost to Dodgers (27-20), 7-1 | Ebbets Field (1-2) | 17-27 | |
| » Starters: Dutch Leonard vs Preacher Roe | Seventh | 8½ out |
| Wednesday, June 8 |
| » Lost to Dodgers (28-20), 3-1 | Ebbets Field (1-3) | 17-28 | Lost 2 |
| » Starters: Bob Muncrief vs Rex Barney | Seventh | 9½ out |
| Thursday, June 9 |
| » Lost to Dodgers (29-20), 9-5 | Ebbets Field (1-4) | 17-29 | Lost 3 |
| » Starters: Johnny Schmitz vs Ralph Branca | Sixth | 10½ out |
| Friday, June 10 |
| » Lost to Braves (29-20), 6-2 | Braves Field (1-2) | 17-30 | Lost 4 |
| » Starters: Bob Rush vs Warren Spahn | Eighth | 11½ out |
| Saturday, June 11 |
| » Defeated Braves (29-21), 5-2 | Braves Field (2-2) | 18-30 | |
| » Starters: Monk Dubiel vs Vern Bickford | Sixth | 11½ out |
| Sunday, June 12 |
| » Defeated Braves (29-22), 6-2 | Braves Field (3-2) | 19-30 | Won 2 |
| » Starters: Johnny Schmitz vs Johnny Sain | Seventh | 12 out |
| » Lost to Braves (30-22), 2-0 | Braves Field (3-3) | 19-31 | |
| » Starters: Dutch Leonard vs Johnny Antonelli | Seventh | 12 out |
| Tuesday, June 14 |
| » Lost to Phillies (29-25), 9-2 | Wrigley Field (8-12) | 19-32 | Lost 2 |
| » Manager: Frankie Frisch |
| » Starters: Russ Meyer vs Bob Muncrief | Eighth | 13 out |
| Wednesday, June 15 |
| » Lost to Phillies (30-25), 4-1 | Wrigley Field (8-13) | 19-33 | Lost 3 |
| » Starters: Ken Heintzelman vs Bob Rush | Eighth | 13½ out |
| » Lost to Phillies (31-25), 3-0 | Wrigley Field (8-14) | 19-34 | Lost 4 |
| » Starters: Hank Borowy vs Johnny Schmitz | Eighth | 13½ out |
| Thursday, June 16 |
| » Lost to Phillies (32-25), 4-3 | Wrigley Field (8-15) | 19-35 | Lost 5 |
| » Starters: Schoolboy Rowe vs Monk Dubiel | Eighth | 13½ out |
| Friday, June 17 |
| » Lost to Dodgers (34-22), 2-1 | Wrigley Field (8-16) | 19-36 | Lost 6 |
| » Starters: Don Newcombe vs Warren Hacker | Eighth | 14½ out |
| Saturday, June 18 |
| » Lost to Dodgers (35-22), 2-0 | Wrigley Field (8-17) | 19-37 | Lost 7 |
| » Starters: Rex Barney vs Dutch Leonard | Eighth | 15½ out |
| Sunday, June 19 |
| » Defeated Dodgers (35-23), 8-2 | Wrigley Field (9-17) | 20-37 | |
| » Starters: Jack Banta vs Johnny Schmitz | Eighth | 14½ out |
| Monday, June 20 |
| » Lost to Braves (34-26), 3-2 | Wrigley Field (9-18) | 20-38 | |
| » Starters: Vern Bickford vs Bob Rush | Eighth | 15 out |
| Tuesday, June 21 |
| » Defeated Braves (34-27), 8-4 | Wrigley Field (10-18) | 21-38 | |
| » Starters: Johnny Sain vs Monk Dubiel | Eighth | 15 out |
| Wednesday, June 22 |
| » Defeated Braves (34-28), 9-8 | Wrigley Field (11-18) | 22-38 | Won 2 |
| » Starters: Bob Hall vs Warren Hacker | Eighth | 14 out |
| Thursday, June 23 |
| » Lost to Braves (35-28), 12-5 | Wrigley Field (11-19) | 22-39 | |
| » Starters: Warren Spahn vs Dutch Leonard | Eighth | 15 out |
| Friday, June 24 |
| » Defeated Giants (30-31), 6-2 | Wrigley Field (12-19) | 23-39 | |
| » Starters: Larry Jansen vs Warren Hacker | Eighth | 14½ out |
| Saturday, June 25 |
| » Defeated Giants (30-32), 4-1 | Wrigley Field (13-19) | 24-39 | Won 2 |
| » Starters: Monte Kennedy vs Bob Rush | Eighth | 14 out |
| Sunday, June 26 |
| » Lost to Giants (31-32), 6-2 | Wrigley Field (13-20) | 24-40 | |
| » Starters: Dave Koslo vs Dutch Leonard | Eighth | 15 out |
| Monday, June 27 |
| » Defeated Cardinals (38-26), 6-4 | Sportsman's Park III (2-2) | 25-40 | |
| » Starters: Johnny Schmitz vs Gerry Staley | Eighth | 14½ out |
| Tuesday, June 28 |
| » Lost to Cardinals (39-26), 5-0 | Sportsman's Park III (2-3) | 25-41 | |
| » Starters: Bob Chipman vs Howie Pollet | Eighth | 15½ out |
| Wednesday, June 29 |
| » Lost to Cardinals (40-26), 7-4 | Sportsman's Park III (2-4) | 25-42 | Lost 2 |
| » Starters: Warren Hacker vs Al Brazle | Eighth | 16½ out |
| Thursday, June 30 |
| » Defeated Cardinals (40-27), 12-5 | Sportsman's Park III (3-4) | 26-42 | |
| » Starters: Bob Rush vs Red Munger | Seventh | 15½ out |
| Friday, July 1 |
| » Defeated Pirates (27-40), 6-5 | Wrigley Field (14-20) | 27-42 | Won 2 |
| » Starters: Bob Chesnes vs Dutch Leonard | Eighth | 14½ out |
| Saturday, July 2 |
| » Lost to Pirates (28-40), 8-3 | Wrigley Field (14-21) | 27-43 | |
| » Starters: Tiny Bonham vs Monk Dubiel | Seventh | 15½ out |
| » Major-league debuts: Tom Saffell (Pirates) |
| Sunday, July 3 |
| » Lost to Pirates (29-40), 7-3 | Wrigley Field (14-22) | 27-44 | Lost 2 |
| » Starters: Vic Lombardi vs Warren Hacker | Eighth | 15½ out |
| Monday, July 4 |
| » Lost to Cardinals (42-29), 9-4 | Wrigley Field (14-23) | 27-45 | Lost 3 |
| » Starters: Max Lanier vs Johnny Schmitz | Seventh | 16½ out |
| » Defeated Cardinals (42-30), 5-0 | Wrigley Field (15-23) | 28-45 | |
| » Starters: Al Brazle vs Bob Chipman | Seventh | 16½ out |
| Tuesday, July 5 |
| » Lost to Cardinals (43-30), 2-1 | Wrigley Field (15-24) | 28-46 | |
| » Starters: Harry Brecheen vs Bob Rush | Eighth | 16½ out |
| Wednesday, July 6 |
| » Lost to Reds (30-41), 23-4 | Crosley Field (2-3) | 28-47 | Lost 2 |
| » Starters: Monk Dubiel vs Ken Raffensberger | Seventh | 16½ out |
| Thursday, July 7 |
| » Lost to Reds (31-41), 7-6 | Crosley Field (2-4) | 28-48 | Lost 3 |
| » Starters: Johnny Schmitz vs Johnny Vander Meer | Seventh | 17½ out |
| Friday, July 8 |
| » Lost to Pirates (34-40), 2-1 | Forbes Field (1-3) | 28-49 | Lost 4 |
| » Starters: Dutch Leonard vs Vic Lombardi | Eighth | 18½ out |
| Saturday, July 9 |
| » Lost to Pirates (35-40), 6-5 | Forbes Field (1-4) | 28-50 | Lost 5 |
| » Starters: Warren Hacker vs Cliff Chambers | Eighth | 18½ out |
| Sunday, July 10 |
| » Defeated Pirates (35-41), 8-6 | Forbes Field (2-4) | 29-50 | |
| » Starters: Bob Rush vs Bob Chesnes | Eighth | 18 out |
| » Defeated Pirates (35-42), 9-6 | Forbes Field (3-4) | 30-50 | Won 2 |
| » Starters: Bob Chipman vs Bill Werle | Eighth | 18 out |
| Thursday, July 14 |
| » Defeated Braves (43-37), 3-2 | Braves Field (4-3) | 31-50 | Won 3 |
| » Starters: Dutch Leonard vs Vern Bickford | Eighth | 18 out |
| Friday, July 15 |
| » Lost to Braves (44-37), 6-1 | Braves Field (4-4) | 31-51 | |
| » Starters: Warren Hacker vs Warren Spahn | Eighth | 19 out |
| Saturday, July 16 |
| » Lost to Braves (45-37), 9-1 | Braves Field (4-5) | 31-52 | Lost 2 |
| » Starters: Bob Chipman vs Johnny Sain | Eighth | 19 out |
| Sunday, July 17 |
| » Lost to Dodgers (50-32), 4-3 | Ebbets Field (1-5) | 31-53 | Lost 3 |
| » Starters: Johnny Schmitz vs Erv Palica | Eighth | 20 out |
| Monday, July 18 |
| » Lost to Dodgers (51-32), 3-0 | Ebbets Field (1-6) | 31-54 | Lost 4 |
| » Starters: Bob Rush vs Joe Hatten | Eighth | 21 out |
| Tuesday, July 19 |
| » Lost to Phillies (44-41), 1-0 | Shibe Park (2-4) | 31-55 | Lost 5 |
| » Starters: Doyle Lade vs Ken Heintzelman | Eighth | 22 out |
| Wednesday, July 20 |
| » Defeated Phillies (44-42), 4-3 | Shibe Park (3-4) | 32-55 | |
| » Starters: Dutch Leonard vs Robin Roberts | Eighth | 21 out |
| Thursday, July 21 |
| » Lost to Phillies (45-42), 8-4 | Shibe Park (3-5) | 32-56 | |
| » Starters: Monk Dubiel vs Hank Borowy | Eighth | 22 out |
| Friday, July 22 |
| » Defeated Giants (43-42), 6-5 | Polo Grounds V (2-4) | 33-56 | |
| » Starters: Johnny Schmitz vs Monte Kennedy | Eighth | 21 out |
| Saturday, July 23 |
| » Lost to Giants (44-42), 10-6 | Polo Grounds V (2-5) | 33-57 | |
| » Starters: Warren Hacker vs Sheldon Jones | Eighth | 21 out |
| Sunday, July 24 |
| » Defeated Giants (44-43), 5-3 | Polo Grounds V (3-5) | 34-57 | |
| » Starters: Bob Rush vs Dave Koslo | Eighth | 20 out |
| » Defeated Giants (44-44), 6-1 | Polo Grounds V (4-5) | 35-57 | Won 2 |
| » Starters: Doyle Lade vs Larry Jansen | Eighth | 20 out |
| Tuesday, July 26 |
| » Defeated Dodgers (53-37), 6-0 | Wrigley Field (16-24) | 36-57 | Won 3 |
| » Starters: Joe Hatten vs Johnny Schmitz | Eighth | 20 out |
| Wednesday, July 27 |
| » Lost to Dodgers (54-37), 7-3 | Wrigley Field (16-25) | 36-58 | |
| » Starters: Don Newcombe vs Dutch Leonard | Eighth | 21 out |
| Thursday, July 28 |
| » Lost to Dodgers (55-37), 7-1 | Wrigley Field (16-26) | 36-59 | Lost 2 |
| » Starters: Ralph Branca vs Bob Rush | Eighth | 22 out |
| Saturday, July 30 |
| » Lost to Phillies (48-47), 4-3 | Wrigley Field (16-27) | 36-60 | Lost 3 |
| » Starters: Russ Meyer vs Doyle Lade | Eighth | 23½ out |
| » Lost to Phillies (49-47), 9-1 | Wrigley Field (16-28) | 36-61 | Lost 4 |
| » Starters: Robin Roberts vs Johnny Schmitz | Eighth | 23½ out |
| Sunday, July 31 |
| » Lost to Phillies (50-47), 5-4 | Wrigley Field (16-29) | 36-62 | Lost 5 |
| » Starters: Hank Borowy vs Warren Hacker | Eighth | 23½ out |
| Monday, August 1 |
| » Lost to Giants (50-46), 11-3 | Wrigley Field (16-30) | 36-63 | Lost 6 |
| » Starters: Clint Hartung vs Bob Chipman | Eighth | 23½ out |
| Tuesday, August 2 |
| » Lost to Giants (51-46), 3-0 | Wrigley Field (16-31) | 36-64 | Lost 7 |
| » Starters: Sheldon Jones vs Dutch Leonard | Eighth | 24½ out |
| Wednesday, August 3 |
| » Lost to Giants (52-46), 4-1 | Wrigley Field (16-32) | 36-65 | Lost 8 |
| » Starters: Dave Koslo vs Bob Rush | Eighth | 25½ out |
| Thursday, August 4 |
| » Defeated Giants (52-47), 1-0 | Wrigley Field (17-32) | 37-65 | |
| » Starters: Larry Jansen vs Johnny Schmitz | Eighth | 25½ out |
| Friday, August 5 |
| » Defeated Braves (52-50), 8-3 | Wrigley Field (18-32) | 38-65 | Won 2 |
| » Starters: Warren Spahn vs Doyle Lade | Eighth | 25½ out |
| Saturday, August 6 |
| » Defeated Braves (52-51), 10-4 | Wrigley Field (19-32) | 39-65 | Won 3 |
| » Starters: Vern Bickford vs Monk Dubiel | Eighth | 24½ out |
| » Major-league debuts: Wayne Terwilliger (Cubs) |
| Sunday, August 7 |
| » Lost to Braves (53-51), 11-0 | Wrigley Field (19-33) | 39-66 | |
| » Starters: Bill Voiselle vs Dutch Leonard | Sixth | 25 out |
| » Defeated Braves (53-52), 4-3 | Wrigley Field (20-33) | 40-66 | |
| » Starters: Nels Potter vs Warren Hacker | Sixth | 25 out |
| Tuesday, August 9 |
| » Lost to Pirates (47-56), 8-3 | Wrigley Field (20-34) | 40-67 | |
| » Starters: Cliff Chambers vs Johnny Schmitz | Sixth | 26½ out |
| Wednesday, August 10 |
| » Defeated Pirates (47-57), 2-0 | Wrigley Field (21-34) | 41-67 | |
| » Starters: Junior Walsh vs Doyle Lade | Seventh | 26½ out |
| Thursday, August 11 |
| » Lost to Pirates (48-57), 3-2 | Wrigley Field (21-35) | 41-68 | |
| » Starters: Bill Werle vs Monk Dubiel | Eighth | 27½ out |
| Saturday, August 13 |
| » Defeated Reds (43-65), 5-4 | Wrigley Field (22-35) | 42-68 | |
| » Starters: Howie Fox vs Dutch Leonard | Seventh | 26½ out |
| Future Cub Andre Thornton is born in Tuskegee, AL. |
| Sunday, August 14 |
| » Lost to Reds (44-65), 4-2 | Wrigley Field (22-36) | 42-69 | |
| » Starters: Ken Raffensberger vs Johnny Schmitz | Eighth | 28 out |
| » Lost to Reds (45-65), 8-0 | Wrigley Field (22-37) | 42-70 | Lost 2 |
| » Starters: Johnny Vander Meer vs Bob Rush | Eighth | 28 out |
| Monday, August 15 |
| » Lost to Cardinals (68-41), 5-2 | Wrigley Field (22-38) | 42-71 | Lost 3 |
| » Starters: Harry Brecheen vs Bob Chipman | Eighth | 28½ out |
| Tuesday, August 16 |
| » Defeated Cardinals (68-42), 5-4 | Wrigley Field (23-38) | 43-71 | |
| » Starters: Max Lanier vs Monk Dubiel | Eighth | 27½ out |
| Thursday, August 18 |
| » Lost to Pirates (52-59), 2-0 | Forbes Field (3-5) | 43-72 | |
| » Starters: Doyle Lade vs Junior Walsh | Eighth | 28 out |
| Friday, August 19 |
| » Defeated Reds (46-68), 7-4 | Crosley Field (3-4) | 44-72 | |
| » Starters: Dutch Leonard vs Herm Wehmeier | Seventh | 27 out |
| Saturday, August 20 |
| » Lost to Reds (47-68), 7-4 | Crosley Field (3-5) | 44-73 | |
| » Starters: Johnny Schmitz vs Johnny Vander Meer | Eighth | 28 out |
| Sunday, August 21 |
| » Defeated Reds (47-69), 5-4 | Crosley Field (4-5) | 45-73 | |
| » Starters: Bob Chipman vs Howie Fox | Eighth | 28 out |
| » Lost to Reds (48-69), 4-1 | Crosley Field (4-6) | 45-74 | |
| » Starters: Bob Rush vs Ken Raffensberger | Eighth | 28 out |
| Tuesday, August 23 |
| » Defeated Giants (58-58), 7-5 | Polo Grounds V (5-5) | 46-74 | |
| » Starters: Doyle Lade vs Dave Koslo | Eighth | 27½ out |
| Wednesday, August 24 |
| » Lost to Giants (59-58), 5-3 | Polo Grounds V (5-6) | 46-75 | |
| » Starters: Dewey Adkins vs Sheldon Jones | Eighth | 27½ out |
| Thursday, August 25 |
| » Defeated Dodgers (71-48), 4-0 | Ebbets Field (2-6) | 47-75 | |
| » Starters: Johnny Schmitz vs Rex Barney | Eighth | 28 out |
| » Lost to Dodgers (72-48), 3-1 | Ebbets Field (2-7) | 47-76 | |
| » Starters: Dutch Leonard vs Jack Banta | Eighth | 28 out |
| Friday, August 26 |
| » Defeated Dodgers (72-49), 4-2 | Ebbets Field (3-7) | 48-76 | |
| » Starters: Bob Rush vs Joe Hatten | Eighth | 27 out |
| Saturday, August 27 |
| » Lost to Dodgers (73-49), 6-1 | Ebbets Field (3-8) | 48-77 | |
| » Starters: Warren Hacker vs Preacher Roe | Eighth | 28½ out |
| Sunday, August 28 |
| » Defeated Phillies (62-62), 7-4 | Shibe Park (4-5) | 49-77 | |
| » Starters: Doyle Lade vs Hank Borowy | Eighth | 29½ out |
| » Lost to Phillies (63-62), 8-2 | Shibe Park (4-6) | 49-78 | |
| » Starters: Dewey Adkins vs Russ Meyer | Eighth | 29½ out |
| Monday, August 29 |
| » Lost to Phillies (64-62), 6-5 | Shibe Park (4-7) | 49-79 | Lost 2 |
| » Starters: Dutch Leonard vs Robin Roberts | Eighth | 30½ out |
| Wednesday, August 31 |
| » Lost to Braves (66-60), 4-3 | Braves Field (4-6) | 49-80 | Lost 3 |
| » Starters: Johnny Schmitz vs Johnny Sain | Eighth | 30½ out |
| Thursday, September 1 |
| » Lost to Braves (67-60), 8-4 | Braves Field (4-7) | 49-81 | Lost 4 |
| » Starters: Doyle Lade vs Warren Spahn | Eighth | 31½ out |
| Saturday, September 3 |
| » Defeated Pirates (57-70), 11-7 | Wrigley Field (24-38) | 50-81 | |
| » Starters: Cliff Chambers vs Monk Dubiel | Eighth | 31 out |
| Sunday, September 4 |
| » Defeated Pirates (57-71), 11-7 | Wrigley Field (25-38) | 51-81 | Won 2 |
| » Starters: Bob Chesnes vs Bob Muncrief | Eighth | 31½ out |
| Monday, September 5 |
| » Lost to Reds (52-77), 7-3 | Wrigley Field (25-39) | 51-82 | |
| » Starters: Herm Wehmeier vs Dutch Leonard | Eighth | 31½ out |
| » Defeated Reds (52-78), 7-2 | Wrigley Field (26-39) | 52-82 | |
| » Starters: Johnny Vander Meer vs Johnny Schmitz | Eighth | 31½ out |
| Wednesday, September 7 |
| » Lost to Cardinals (83-49), 3-2 | Sportsman's Park III (3-5) | 52-83 | |
| » Starters: Doyle Lade vs Howie Pollet | Eighth | 32½ out |
| Thursday, September 8 |
| » Lost to Cardinals (84-49), 8-0 | Sportsman's Park III (3-6) | 52-84 | Lost 2 |
| » Starters: Bob Rush vs Harry Brecheen | Eighth | 33½ out |
| Friday, September 9 |
| » Defeated Pirates (58-76), 8-1 | Forbes Field (4-5) | 53-84 | |
| » Starters: Monk Dubiel vs Bob Chesnes | Eighth | 32½ out |
| Saturday, September 10 |
| » Defeated Pirates (58-77), 9-5 | Forbes Field (5-5) | 54-84 | Won 2 |
| » Starters: Dutch Leonard vs Bill Werle | Eighth | 32½ out |
| Sunday, September 11 |
| » Lost to Pirates (59-77), 7-3 | Forbes Field (5-6) | 54-85 | |
| » Starters: Dewey Adkins vs Murry Dickson | Eighth | 34 out |
| Wednesday, September 14 |
| » Defeated Braves (68-72), 8-7 | Wrigley Field (27-39) | 55-85 | |
| » Starters: Johnny Sain vs Johnny Schmitz | Eighth | 34½ out |
| Friday, September 16 |
| » Defeated Giants (67-73), 5-4 | Wrigley Field (28-39) | 56-85 | Won 2 |
| » Starters: Larry Jansen vs Doyle Lade | Eighth | 34½ out |
| » Major-league debuts: Davey Williams (Giants) |
| Future Cub Mike Garman is born in Caldwell, ID. |
| Saturday, September 17 |
| » Defeated Giants (67-74), 4-2 | Wrigley Field (29-39) | 57-85 | Won 3 |
| » Starters: Dave Koslo vs Dutch Leonard | Eighth | 33½ out |
| Sunday, September 18 |
| » Lost to Dodgers (89-54), 7-1 | Wrigley Field (29-40) | 57-86 | |
| » Starters: Ralph Branca vs Monk Dubiel | Eighth | 34½ out |
| Monday, September 19 |
| » Lost to Dodgers (90-54), 4-0 | Wrigley Field (29-41) | 57-87 | Lost 2 |
| » Starters: Rex Barney vs Bob Rush | Eighth | 34½ out |
| Tuesday, September 20 |
| » Lost to Dodgers (91-54), 5-0 | Wrigley Field (29-42) | 57-88 | Lost 3 |
| » Starters: Jack Banta vs Johnny Schmitz | Eighth | 35½ out |
| Wednesday, September 21 |
| » Lost to Phillies (78-69), 3-1 | Wrigley Field (29-43) | 57-89 | Lost 4 |
| » Starters: Russ Meyer vs Warren Hacker | Eighth | 35½ out |
| » Defeated Phillies (78-70), 9-6 | Wrigley Field (30-43) | 58-89 | |
| » Starters: Robin Roberts vs Doyle Lade | Eighth | 35½ out |
| Thursday, September 22 |
| » Defeated Phillies (78-71), 3-2 | Wrigley Field (31-43) | 59-89 | Won 2 |
| » Starters: Hank Borowy vs Dewey Adkins | Eighth | 34½ out |
| Friday, September 23 |
| » Major-league debuts: Wally Hood (Yankees) |
| Saturday, September 24 |
| » Lost to Cardinals (94-54), 3-2 | Sportsman's Park III (3-7) | 59-90 | |
| » Starters: Bob Rush vs Gerry Staley | Eighth | 35½ out |
| Sunday, September 25 |
| » Lost to Cardinals (95-54), 6-1 | Sportsman's Park III (3-8) | 59-91 | Lost 2 |
| » Starters: Johnny Schmitz vs Harry Brecheen | Eighth | 36½ out |
| Tuesday, September 27 |
| » Lost to Reds (61-90), 5-4 | Crosley Field (4-7) | 59-92 | Lost 3 |
| » Starters: Dutch Leonard vs Ken Raffensberger | Eighth | 36½ out |
| Friday, September 30 |
| » Defeated Cardinals (95-57), 6-5 | Wrigley Field (32-43) | 60-92 | |
| » Starters: Max Lanier vs Bob Rush | Seventh | 36 out |
| Saturday, October 1 |
| » Defeated Cardinals (95-58), 3-1 | Wrigley Field (33-43) | 61-92 | Won 2 |
| » Starters: Harry Brecheen vs Bob Chipman | Eighth | 35 out |
| Sunday, October 2 |
| » Lost to Cardinals (96-58), 13-5 | Wrigley Field (33-44) | 61-93 | |
| » Starters: Howie Pollet vs Johnny Schmitz | Eighth | 36 out |
| Monday, October 10 |
| Future Cub Rob Sperring is born in San Francisco, CA. |
| Wednesday, December 14 |
| Future Cub Bill Buckner is born in Vallejo, CA. |
| Tuesday, December 20 |
| Future Cub Oscar Gamble is born in Ramer, AL. |
| Friday, December 30 |
| Former Cub Doc Watson dies in San Diego, CA at the age of 64. |
Game information provided by Retrosheet (www.retrosheet.org) |