| Saturday, January 15 |
| Future Cardinal Luis Alvarado is born in Lajas, P.R. |
| Thursday, February 3 |
| Future Cardinal Bake McBride is born in Fulton, MO. |
| Wednesday, February 16 |
| Former Cardinal Tommy Raub dies in Phillipsburg, NJ at the age of 79. |
| Friday, February 18 |
| Future Cardinal Jerry Morales is born in Yabucoa, P.R. |
| Friday, April 15 |
| Future Cardinal Ray Bare is born in Miami, FL. |
| Tuesday, April 19 |
| » Lost to Reds (1-0), 3-1 | Crosley Field (0-1) | 0-1 | |
| » Starters: Harry Brecheen vs Ken Raffensberger | Fourth | 1 out |
| » Major-league debuts: Tommy Glaviano (Cardinals) |
| Thursday, April 21 |
| » Lost to Reds (2-0), 5-0 | Crosley Field (0-2) | 0-2 | Lost 2 |
| » Starters: Howie Pollet vs Johnny Vander Meer | Sixth | 2 out |
| Friday, April 22 |
| » Defeated Cubs (2-2), 9-2 | Sportsman's Park III (1-0) | 1-2 | |
| » Starters: Johnny Schmitz vs Al Brazle | Fourth | 1½ out |
| Saturday, April 23 |
| » Lost to Cubs (3-2), 11-7 | Sportsman's Park III (1-1) | 1-3 | |
| » Starters: Dewey Adkins vs Red Munger | Fifth | 2 out |
| » Major-league debuts: Cloyd Boyer and Bill Reeder (Cardinals) |
| Sunday, April 24 |
| » Defeated Cubs (3-3), 5-4 | Sportsman's Park III (2-1) | 2-3 | |
| » Starters: Lefty Sloat vs Jim Hearn | Fourth | 1½ out |
| Monday, April 25 |
| » Defeated Reds (3-3), 9-3 | Sportsman's Park III (3-1) | 3-3 | Won 2 |
| » Starters: Ken Raffensberger vs Harry Brecheen | Third | 1 out |
| » Major-league debuts: Frank Fanovich (Reds) |
| Wednesday, April 27 |
| » Lost to Pirates (5-3), 7-1 | Sportsman's Park III (3-2) | 3-4 | |
| » Starters: Murry Dickson vs Howie Pollet | Fourth | 1½ out |
| » Major-league debuts: Solly Hemus (Cardinals) Rocky Nelson (Pirates) |
| Thursday, April 28 |
| » Defeated Pirates (5-4), 4-2 | Sportsman's Park III (4-2) | 4-4 | |
| » Starters: Bob Muncrief vs Al Brazle | Third | 1 out |
| Friday, April 29 |
| » Lost to Cubs (5-5), 5-4 | Wrigley Field (0-1) | 4-5 | |
| » Starters: Red Munger vs Johnny Schmitz | Fifth | 1½ out |
| Saturday, April 30 |
| » Defeated Cubs (5-6), 4-3 | Wrigley Field (1-1) | 5-5 | |
| » Starters: Cloyd Boyer vs Bob Rush | Fourth | 1 out |
| Sunday, May 1 |
| » Defeated Cubs (5-7), 8-3 | Wrigley Field (2-1) | 6-5 | Won 2 |
| » Starters: Harry Brecheen vs Dutch Leonard | Third | 1½ out |
| Tuesday, May 3 |
| » Lost to Phillies (7-8), 7-3 | Shibe Park (0-1) | 6-6 | |
| » Starters: Ken Johnson vs Robin Roberts | Third | 1½ out |
| Wednesday, May 4 |
| » Lost to Phillies (8-8), 7-5 | Shibe Park (0-2) | 6-7 | Lost 2 |
| » Starters: Al Brazle vs Ken Heintzelman | Fifth | 2½ out |
| Thursday, May 5 |
| » Defeated Phillies (8-9), 3-2 | Shibe Park (1-2) | 7-7 | |
| » Starters: Red Munger vs Hank Borowy | Third | 2 out |
| Friday, May 6 |
| » Lost to Giants (10-7), 3-0 | Polo Grounds V (0-1) | 7-8 | |
| » Starters: Jim Hearn vs Monte Kennedy | Fifth | 3 out |
| Saturday, May 7 |
| » Lost to Giants (11-7), 9-1 | Polo Grounds V (0-2) | 7-9 | Lost 2 |
| » Starters: Harry Brecheen vs Clint Hartung | Fifth | 3 out |
| Sunday, May 8 |
| » Lost to Dodgers (11-8), 8-7 | Ebbets Field (0-1) | 7-10 | Lost 3 |
| » Starters: Ken Johnson vs Joe Hatten | Seventh | 4 out |
| Monday, May 9 |
| » Defeated Dodgers (11-9), 14-5 | Ebbets Field (1-1) | 8-10 | |
| » Starters: Al Brazle vs Bud Podbielan | Sixth | 4 out |
| Wednesday, May 11 |
| » Lost to Braves (13-9), 7-0 | Braves Field (0-1) | 8-11 | |
| » Starters: Red Munger vs Warren Spahn | Sixth | 4 out |
| Friday, May 13 |
| » Lost to Pirates (11-13), 3-2 | Forbes Field (0-1) | 8-12 | Lost 2 |
| » Starters: Harry Brecheen vs Rip Sewell | Fifth | 4½ out |
| Future Cardinal Terry Hughes is born in Spartanburg, SC. |
| Saturday, May 14 |
| » Defeated Pirates (11-14), 4-3 | Forbes Field (1-1) | 9-12 | |
| » Starters: Howie Pollet vs Murry Dickson | Fifth | 4½ out |
| Sunday, May 15 |
| » Defeated Pirates (11-15), 4-3 | Forbes Field (2-1) | 10-12 | Won 2 |
| » Starters: Jim Hearn vs Bill Werle | Fourth | 4½ out |
| Tuesday, May 17 |
| » Lost to Phillies (12-15), 5-4 | Sportsman's Park III (4-3) | 10-13 | |
| » Starters: Ken Heintzelman vs Al Brazle | Fifth | 4½ out |
| Wednesday, May 18 |
| » Lost to Phillies (13-15), 3-2 | Sportsman's Park III (4-4) | 10-14 | Lost 2 |
| » Starters: Curt Simmons vs Harry Brecheen | Fifth | 4½ out |
| Thursday, May 19 |
| » Lost to Dodgers (15-13), 2-0 | Sportsman's Park III (4-5) | 10-15 | Lost 3 |
| » Starters: Preacher Roe vs Howie Pollet | Fifth | 5½ out |
| Friday, May 20 |
| » Defeated Dodgers (15-14), 6-2 | Sportsman's Park III (5-5) | 11-15 | |
| » Starters: Morrie Martin vs Red Munger | Sixth | 5½ out |
| » Major-league debuts: Don Newcombe (Dodgers) |
| Saturday, May 21 |
| » Lost to Dodgers (16-14), 15-6 | Sportsman's Park III (5-6) | 11-16 | |
| » Starters: Ralph Branca vs Jim Hearn | Seventh | 6 out |
| Sunday, May 22 |
| » Defeated Giants (18-12), 3-2 | Sportsman's Park III (6-6) | 12-16 | |
| » Starters: Clint Hartung vs Al Brazle | Sixth | 6 out |
| » Lost to Giants (19-12), 13-4 | Sportsman's Park III (6-7) | 12-17 | |
| » Starters: Larry Jansen vs Bill Reeder | Sixth | 6 out |
| Tuesday, May 24 |
| » Defeated Braves (20-13), 3-1 | Sportsman's Park III (7-7) | 13-17 | |
| » Starters: Johnny Antonelli vs Harry Brecheen | Sixth | 5½ out |
| Wednesday, May 25 |
| » Defeated Braves (20-14), 3-0 | Sportsman's Park III (8-7) | 14-17 | Won 2 |
| » Starters: Warren Spahn vs Howie Pollet | Sixth | 4½ out |
| Thursday, May 26 |
| » Defeated Pirates (14-21), 13-6 | Sportsman's Park III (9-7) | 15-17 | Won 3 |
| » Starters: Kirby Higbe vs Red Munger | Fifth | 4 out |
| Future Cardinal Ed Crosby is born in Long Beach, CA. |
| Friday, May 27 |
| » Defeated Pirates (14-22), 2-1 | Sportsman's Park III (10-7) | 16-17 | Won 4 |
| » Starters: Murry Dickson vs Al Brazle | Fourth | 3 out |
| Saturday, May 28 |
| » Defeated Pirates (14-23), 4-2 | Sportsman's Park III (11-7) | 17-17 | Won 5 |
| » Starters: Bill Werle vs Gerry Staley | Fourth | 3 out |
| Sunday, May 29 |
| » Lost to Pirates (15-23), 4-2 | Sportsman's Park III (11-8) | 17-18 | |
| » Starters: Elmer Riddle vs Harry Brecheen | Third | 3 out |
| Monday, May 30 |
| » Defeated Reds (20-18), 8-6 | Sportsman's Park III (12-8) | 18-18 | |
| » Starters: Johnny Vander Meer vs Red Munger | Second | 2 out |
| » Defeated Reds (20-19), 9-2 | Sportsman's Park III (13-8) | 19-18 | Won 2 |
| » Starters: Buddy Lively vs Howie Pollet | Second | 2 out |
| Wednesday, June 1 |
| » Defeated Dodgers (23-18), 6-3 | Ebbets Field (2-1) | 20-18 | Won 3 |
| » Starters: Al Brazle vs Preacher Roe | Third | 2½ out |
| Thursday, June 2 |
| » Defeated Dodgers (23-19), 7-4 | Ebbets Field (3-1) | 21-18 | Won 4 |
| » Starters: Harry Brecheen vs Don Newcombe | Third | 2½ out |
| Friday, June 3 |
| » Lost to Dodgers (24-19), 5-2 | Ebbets Field (3-2) | 21-19 | |
| » Starters: Gerry Staley vs Joe Hatten | Third | 3 out |
| Saturday, June 4 |
| » Defeated Braves (25-18), 2-1 | Braves Field (1-1) | 22-19 | |
| » Starters: Howie Pollet vs Johnny Sain | Third | 2 out |
| Sunday, June 5 |
| » Defeated Braves (25-19), 8-1 | Braves Field (2-1) | 23-19 | Won 2 |
| » Starters: Al Brazle vs Johnny Antonelli | Fourth | 1½ out |
| Monday, June 6 |
| » Defeated Braves (25-20), 7-3 | Braves Field (3-1) | 24-19 | Won 3 |
| » Starters: Red Munger vs Warren Spahn | Second | 1½ out |
| Tuesday, June 7 |
| » Defeated Giants (26-21), 3-0 | Polo Grounds V (1-2) | 25-19 | Won 4 |
| » Starters: Harry Brecheen vs Monte Kennedy | Second | 1½ out |
| Former Cardinal Hi Bell dies in Glendale, CA at the age of 52. |
| Wednesday, June 8 |
| » Defeated Giants (26-22), 2-0 | Polo Grounds V (2-2) | 26-19 | Won 5 |
| » Starters: Gerry Staley vs Dave Koslo | Second | 1½ out |
| Thursday, June 9 |
| » Defeated Giants (26-23), 4-1 | Polo Grounds V (3-2) | 27-19 | Won 6 |
| » Starters: Howie Pollet vs Clint Hartung | Second | 1½ out |
| Friday, June 10 |
| » Lost to Phillies (27-23), 3-2 | Shibe Park (1-3) | 27-20 | |
| » Starters: Al Brazle vs Ken Heintzelman | Third | 1½ out |
| Saturday, June 11 |
| » Defeated Phillies (27-24), 6-2 | Shibe Park (2-3) | 28-20 | |
| » Starters: Red Munger vs Hank Borowy | Second | 1½ out |
| Sunday, June 12 |
| » Defeated Phillies (27-25), 7-3 | Shibe Park (3-3) | 29-20 | Won 2 |
| » Starters: Harry Brecheen vs Curt Simmons | Second | 2 out |
| » Lost to Phillies (28-25), 8-3 | Shibe Park (3-4) | 29-21 | |
| » Starters: Gerry Staley vs Robin Roberts | Second | 2 out |
| Tuesday, June 14 |
| » Lost to Dodgers (33-20), 7-2 | Sportsman's Park III (13-9) | 29-22 | Lost 2 |
| » Starters: Preacher Roe vs Howie Pollet | Second | 3 out |
| Former Cardinal Charlie Moran dies in Horse Cave, KY at the age of 72. |
| Wednesday, June 15 |
| » Defeated Dodgers (33-21), 9-5 | Sportsman's Park III (14-9) | 30-22 | |
| » Starters: Ralph Branca vs Al Brazle | Second | 2 out |
| Thursday, June 16 |
| » Defeated Dodgers (33-22), 6-2 | Sportsman's Park III (15-9) | 31-22 | Won 2 |
| » Starters: Joe Hatten vs Red Munger | Second | 1 out |
| Friday, June 17 |
| » Lost to Phillies (33-25), 8-0 | Sportsman's Park III (15-10) | 31-23 | |
| » Starters: Robin Roberts vs Harry Brecheen | Second | 2 out |
| Saturday, June 18 |
| » Defeated Phillies (33-26), 4-3 | Sportsman's Park III (16-10) | 32-23 | |
| » Starters: Curt Simmons vs Howie Pollet | Second | 2 out |
| Sunday, June 19 |
| » Defeated Phillies (33-27), 6-5 | Sportsman's Park III (17-10) | 33-23 | Won 2 |
| » Starters: Ken Heintzelman vs Al Brazle | Second | 1 out |
| Future Cardinal Jerry Reuss is born in St. Louis, MO. |
| Monday, June 20 |
| » Defeated Giants (29-28), 7-2 | Sportsman's Park III (18-10) | 34-23 | Won 3 |
| » Starters: Monte Kennedy vs Gerry Staley | Second | ½ out |
| Tuesday, June 21 |
| » Lost to Giants (30-28), 6-5 | Sportsman's Park III (18-11) | 34-24 | |
| » Starters: Dave Koslo vs Red Munger | Second | 1½ out |
| Wednesday, June 22 |
| » Defeated Giants (30-29), 11-8 | Sportsman's Park III (19-11) | 35-24 | |
| » Starters: Sheldon Jones vs Harry Brecheen | Second | ½ out |
| Thursday, June 23 |
| » Defeated Giants (30-30), 10-6 | Sportsman's Park III (20-11) | 36-24 | Won 2 |
| » Starters: Clint Hartung vs Howie Pollet | Second | ½ out |
| Friday, June 24 |
| » Defeated Braves (35-29), 8-4 | Sportsman's Park III (21-11) | 37-24 | Won 3 |
| » Starters: Vern Bickford vs Al Brazle | First | -- |
| Saturday, June 25 |
| » Lost to Braves (36-29), 10-6 | Sportsman's Park III (21-12) | 37-25 | |
| » Starters: Johnny Sain vs Harry Brecheen | Second | ½ out |
| Sunday, June 26 |
| » Defeated Braves (36-30), 2-0 | Sportsman's Park III (22-12) | 38-25 | |
| » Starters: Glenn Elliott vs Red Munger | Second | ½ out |
| Monday, June 27 |
| » Lost to Cubs (25-40), 6-4 | Sportsman's Park III (22-13) | 38-26 | |
| » Starters: Johnny Schmitz vs Gerry Staley | Second | 1 out |
| Tuesday, June 28 |
| » Defeated Cubs (25-41), 5-0 | Sportsman's Park III (23-13) | 39-26 | |
| » Starters: Bob Chipman vs Howie Pollet | Second | 1 out |
| Wednesday, June 29 |
| » Defeated Cubs (25-42), 7-4 | Sportsman's Park III (24-13) | 40-26 | Won 2 |
| » Starters: Warren Hacker vs Al Brazle | Second | 1 out |
| Thursday, June 30 |
| » Lost to Cubs (26-42), 12-5 | Sportsman's Park III (24-14) | 40-27 | |
| » Starters: Bob Rush vs Red Munger | Second | 1 out |
| Friday, July 1 |
| » Lost to Reds (28-38), 10-2 | Sportsman's Park III (24-15) | 40-28 | Lost 2 |
| » Starters: Ken Raffensberger vs Harry Brecheen | Second | 1 out |
| Saturday, July 2 |
| » Lost to Reds (29-38), 3-0 | Sportsman's Park III (24-16) | 40-29 | Lost 3 |
| » Starters: Johnny Vander Meer vs Howie Pollet | Second | 2 out |
| Sunday, July 3 |
| » Defeated Reds (29-39), 8-1 | Sportsman's Park III (25-16) | 41-29 | |
| » Starters: Herm Wehmeier vs Gerry Staley | Second | 1 out |
| Monday, July 4 |
| » Defeated Cubs (27-45), 9-4 | Wrigley Field (3-1) | 42-29 | Won 2 |
| » Starters: Max Lanier vs Johnny Schmitz | Second | 2 out |
| » Lost to Cubs (28-45), 5-0 | Wrigley Field (3-2) | 42-30 | |
| » Starters: Al Brazle vs Bob Chipman | Second | 2 out |
| Tuesday, July 5 |
| » Defeated Cubs (28-46), 2-1 | Wrigley Field (4-2) | 43-30 | |
| » Starters: Harry Brecheen vs Bob Rush | Second | 1 out |
| Wednesday, July 6 |
| » Lost to Pirates (32-40), 4-3 | Forbes Field (2-2) | 43-31 | |
| » Starters: Red Munger vs Elmer Riddle | Second | 1 out |
| Thursday, July 7 |
| » Lost to Pirates (33-40), 2-0 | Forbes Field (2-3) | 43-32 | Lost 2 |
| » Starters: Gerry Staley vs Tiny Bonham | Second | 2 out |
| Friday, July 8 |
| » Defeated Reds (31-42), 6-1 | Crosley Field (1-2) | 44-32 | |
| » Starters: Howie Pollet vs Ewell Blackwell | Second | 2 out |
| Saturday, July 9 |
| » Defeated Reds (31-43), 3-2 | Crosley Field (2-2) | 45-32 | Won 2 |
| » Starters: Max Lanier vs Howie Fox | Second | 1 out |
| Sunday, July 10 |
| » Defeated Reds (31-44), 4-2 | Crosley Field (3-2) | 46-32 | Won 3 |
| » Starters: Harry Brecheen vs Ken Raffensberger | Second | ½ out |
| » Defeated Reds (31-45), 7-4 | Crosley Field (4-2) | 47-32 | Won 4 |
| » Starters: Al Brazle vs Herm Wehmeier | Second | ½ out |
| Monday, July 11 |
| Future Cardinal Jack Heidemann is born in Brenham, TX. |
| Thursday, July 14 |
| » Lost to Phillies (42-38), 1-0 | Shibe Park (3-5) | 47-33 | |
| » Starters: Max Lanier vs Ken Heintzelman | Second | 1½ out |
| Friday, July 15 |
| » Defeated Phillies (42-39), 1-0 | Shibe Park (4-5) | 48-33 | |
| » Starters: Howie Pollet vs Robin Roberts | Second | 1½ out |
| Saturday, July 16 |
| » Lost to Phillies (43-39), 4-2 | Shibe Park (4-6) | 48-34 | |
| » Starters: Harry Brecheen vs Hank Borowy | Second | 1½ out |
| Sunday, July 17 |
| » Defeated Giants (39-41), 10-1 | Polo Grounds V (4-2) | 49-34 | |
| » Starters: Red Munger vs Dave Koslo | Second | 1½ out |
| Former Cardinal Jack Slattery dies in Boston, MA at the age of 72. |
| Monday, July 18 |
| » Lost to Giants (40-41), 7-4 | Polo Grounds V (4-3) | 49-35 | |
| » Starters: Al Brazle vs Monte Kennedy | Second | 2½ out |
| Tuesday, July 19 |
| » Lost to Braves (47-39), 5-2 | Braves Field (3-2) | 49-36 | Lost 2 |
| » Starters: Max Lanier vs Warren Spahn | Second | 3½ out |
| Wednesday, July 20 |
| » Defeated Braves (47-40), 6-4 | Braves Field (4-2) | 50-36 | |
| » Starters: Howie Pollet vs Johnny Sain | Second | 2½ out |
| Thursday, July 21 |
| » Defeated Braves (47-41), 3-1 | Braves Field (5-2) | 51-36 | Won 2 |
| » Starters: Harry Brecheen vs Johnny Antonelli | Second | 2½ out |
| Future Cardinal Al Hrabosky is born in Oakland, CA. |
| Friday, July 22 |
| » Defeated Dodgers (53-34), 3-1 | Ebbets Field (4-2) | 52-36 | Won 3 |
| » Starters: Red Munger vs Preacher Roe | Second | 1½ out |
| Saturday, July 23 |
| » Defeated Dodgers (53-35), 5-4 | Ebbets Field (5-2) | 53-36 | Won 4 |
| » Starters: Gerry Staley vs Joe Hatten | Second | ½ out |
| Sunday, July 24 |
| » Defeated Dodgers (53-36), 14-1 | Ebbets Field (6-2) | 54-36 | Won 5 |
| » Starters: Howie Pollet vs Don Newcombe | First | -- |
| Monday, July 25 |
| » Tied Dodgers, 4-4 | Ebbets Field (6-2) | 54-36 | |
| » Starters: Max Lanier vs Ralph Branca | First | -- |
| Tuesday, July 26 |
| » Defeated Phillies (47-45), 9-5 | Sportsman's Park III (26-16) | 55-36 | Won 6 |
| » Starters: Robin Roberts vs Harry Brecheen | First | -- |
| Wednesday, July 27 |
| » Defeated Phillies (47-46), 7-3 | Sportsman's Park III (27-16) | 56-36 | Won 7 |
| » Starters: Hank Borowy vs Red Munger | First | -- |
| Thursday, July 28 |
| » Defeated Phillies (47-47), 10-2 | Sportsman's Park III (28-16) | 57-36 | Won 8 |
| » Starters: Ken Heintzelman vs Al Brazle | First | -- |
| Friday, July 29 |
| » Tied Dodgers, 3-3 | Sportsman's Park III (28-16) | 57-36 | |
| » Starters: Preacher Roe vs Howie Pollet | First | -- |
| Saturday, July 30 |
| » Defeated Dodgers (55-38), 7-6 | Sportsman's Park III (29-16) | 58-36 | Won 9 |
| » Starters: Joe Hatten vs Max Lanier | First | -- |
| Sunday, July 31 |
| » Lost to Dodgers (56-38), 4-2 | Sportsman's Park III (29-17) | 58-37 | |
| » Starters: Don Newcombe vs Gerry Staley | First | -- |
| Monday, August 1 |
| » Lost to Braves (52-46), 8-1 | Sportsman's Park III (29-18) | 58-38 | Lost 2 |
| » Starters: Warren Spahn vs Harry Brecheen | First | -- |
| Tuesday, August 2 |
| » Defeated Braves (52-47), 7-2 | Sportsman's Park III (30-18) | 59-38 | |
| » Starters: Glenn Elliott vs Red Munger | First | -- |
| Wednesday, August 3 |
| » Defeated Braves (52-48), 7-0 | Sportsman's Park III (31-18) | 60-38 | Won 2 |
| » Starters: Johnny Antonelli vs Howie Pollet | First | -- |
| Thursday, August 4 |
| » Defeated Braves (52-49), 10-2 | Sportsman's Park III (32-18) | 61-38 | Won 3 |
| » Starters: Johnny Sain vs Al Brazle | First | -- |
| Friday, August 5 |
| » Defeated Giants (52-48), 1-0 | Sportsman's Park III (33-18) | 62-38 | Won 4 |
| » Starters: Monte Kennedy vs Gerry Staley | First | -- |
| Saturday, August 6 |
| » Lost to Giants (53-48), 3-1 | Sportsman's Park III (33-19) | 62-39 | |
| » Starters: Adrian Zabala vs Max Lanier | First | -- |
| Sunday, August 7 |
| » Defeated Giants (53-49), 9-2 | Sportsman's Park III (34-19) | 63-39 | |
| » Starters: Clint Hartung vs Red Munger | First | -- |
| Monday, August 8 |
| » Defeated Reds (43-62), 9-3 | Sportsman's Park III (35-19) | 64-39 | Won 2 |
| » Starters: Kent Peterson vs Howie Pollet | First | -- |
| Tuesday, August 9 |
| » Defeated Reds (43-63), 4-1 | Sportsman's Park III (36-19) | 65-39 | Won 3 |
| » Starters: Johnny Vander Meer vs Harry Brecheen | First | -- |
| Future Cardinal Ted Simmons is born in Highland Park, MI. |
| Wednesday, August 10 |
| » Defeated Reds (43-64), 8-0 | Sportsman's Park III (37-19) | 66-39 | Won 4 |
| » Starters: Herm Wehmeier vs Al Brazle | First | -- |
| Thursday, August 11 |
| Future Cardinal Luis Melendez is born in Aibonito, P.R. |
| Friday, August 12 |
| » Defeated Pirates (48-58), 8-2 | Sportsman's Park III (38-19) | 67-39 | Won 5 |
| » Starters: Tiny Bonham vs Gerry Staley | First | -- |
| Saturday, August 13 |
| » Lost to Pirates (49-58), 6-3 | Sportsman's Park III (38-20) | 67-40 | |
| » Starters: Murry Dickson vs Red Munger | First | -- |
| Sunday, August 14 |
| » Lost to Pirates (50-58), 4-0 | Sportsman's Park III (38-21) | 67-41 | Lost 2 |
| » Starters: Cliff Chambers vs Howie Pollet | Second | 1 out |
| Monday, August 15 |
| » Defeated Cubs (42-71), 5-2 | Wrigley Field (5-2) | 68-41 | |
| » Starters: Harry Brecheen vs Bob Chipman | Second | ½ out |
| Tuesday, August 16 |
| » Lost to Cubs (43-71), 5-4 | Wrigley Field (5-3) | 68-42 | |
| » Starters: Max Lanier vs Monk Dubiel | Second | ½ out |
| Wednesday, August 17 |
| » Defeated Reds (46-67), 4-3 | Crosley Field (5-2) | 69-42 | |
| » Starters: Al Brazle vs Ken Raffensberger | First | -- |
| Friday, August 19 |
| » Lost to Pirates (53-59), 8-2 | Forbes Field (2-4) | 69-43 | |
| » Starters: Gerry Staley vs Cliff Chambers | First | -- |
| Saturday, August 20 |
| » Defeated Pirates (53-60), 4-3 | Forbes Field (3-4) | 70-43 | |
| » Starters: Red Munger vs Tiny Bonham | First | -- |
| Sunday, August 21 |
| » Defeated Pirates (53-61), 4-2 | Forbes Field (4-4) | 71-43 | Won 2 |
| » Starters: Fred Martin vs Bill Werle | First | -- |
| » Lost to Pirates (54-61), 8-0 | Forbes Field (4-5) | 71-44 | |
| » Starters: Harry Brecheen vs Murry Dickson | First | -- |
| Monday, August 22 |
| Future Cardinal Doug Bair is born in Defiance, OH. |
| Tuesday, August 23 |
| » Defeated Dodgers (69-47), 5-3 | Ebbets Field (7-2) | 72-44 | |
| » Starters: Max Lanier vs Joe Hatten | First | -- |
| » Lost to Dodgers (70-47), 4-3 | Ebbets Field (7-3) | 72-45 | |
| » Starters: Howie Pollet vs Preacher Roe | First | -- |
| Wednesday, August 24 |
| » Lost to Dodgers (71-47), 6-0 | Ebbets Field (7-4) | 72-46 | Lost 2 |
| » Starters: Al Brazle vs Don Newcombe | First | -- |
| Thursday, August 25 |
| » Defeated Giants (59-59), 5-2 | Polo Grounds V (5-3) | 73-46 | |
| » Starters: Red Munger vs Monte Kennedy | First | -- |
| Friday, August 26 |
| » Lost to Giants (60-59), 4-2 | Polo Grounds V (5-4) | 73-47 | |
| » Starters: Gerry Staley vs Larry Jansen | First | -- |
| Saturday, August 27 |
| » Defeated Giants (60-60), 5-2 | Polo Grounds V (6-4) | 74-47 | |
| » Starters: Fred Martin vs Dave Koslo | First | -- |
| » Defeated Giants (60-61), 11-2 | Polo Grounds V (7-4) | 75-47 | Won 2 |
| » Starters: Harry Brecheen vs Sheldon Jones | First | -- |
| Sunday, August 28 |
| » Defeated Braves (64-58), 9-7 | Braves Field (6-2) | 76-47 | Won 3 |
| » Starters: Howie Pollet vs Warren Spahn | First | -- |
| » Defeated Braves (64-59), 7-1 | Braves Field (7-2) | 77-47 | Won 4 |
| » Starters: Max Lanier vs Glenn Elliott | First | -- |
| Monday, August 29 |
| » Defeated Braves (64-60), 8-2 | Braves Field (8-2) | 78-47 | Won 5 |
| » Starters: Al Brazle vs Bill Voiselle | First | -- |
| Tuesday, August 30 |
| » Lost to Braves (65-60), 12-4 | Braves Field (8-3) | 78-48 | |
| » Starters: Red Munger vs Vern Bickford | First | -- |
| Thursday, September 1 |
| » Defeated Phillies (64-63), 4-0 | Shibe Park (5-6) | 79-48 | |
| » Starters: Howie Pollet vs Ken Heintzelman | First | -- |
| Saturday, September 3 |
| » Tied Reds, 9-9 | Sportsman's Park III (38-21) | 79-48 | |
| » Starters: Johnny Vander Meer vs Harry Brecheen | First | -- |
| Sunday, September 4 |
| » Defeated Reds (51-76), 6-4 | Sportsman's Park III (39-21) | 80-48 | Won 2 |
| » Starters: Ken Raffensberger vs Max Lanier | First | -- |
| » Defeated Reds (51-77), 11-2 | Sportsman's Park III (40-21) | 81-48 | Won 3 |
| » Starters: Frank Fanovich vs Fred Martin | First | -- |
| Monday, September 5 |
| » Defeated Pirates (57-72), 9-1 | Sportsman's Park III (41-21) | 82-48 | Won 4 |
| » Starters: Murry Dickson vs Red Munger | First | -- |
| » Lost to Pirates (58-72), 5-4 | Sportsman's Park III (41-22) | 82-49 | |
| » Starters: Bill Werle vs Gerry Staley | First | -- |
| Tuesday, September 6 |
| Future Cardinal Mike Thompson is born in Denver, CO. |
| Wednesday, September 7 |
| » Defeated Cubs (52-83), 3-2 | Sportsman's Park III (42-22) | 83-49 | |
| » Starters: Doyle Lade vs Howie Pollet | First | -- |
| Thursday, September 8 |
| » Defeated Cubs (52-84), 8-0 | Sportsman's Park III (43-22) | 84-49 | Won 2 |
| » Starters: Bob Rush vs Harry Brecheen | First | -- |
| Friday, September 9 |
| » Lost to Reds (56-78), 6-1 | Crosley Field (5-3) | 84-50 | |
| » Starters: Al Brazle vs Johnny Vander Meer | First | -- |
| Saturday, September 10 |
| » Defeated Reds (56-79), 6-5 | Crosley Field (6-3) | 85-50 | |
| » Starters: Max Lanier vs Howie Fox | First | -- |
| Sunday, September 11 |
| » Defeated Reds (56-80), 7-5 | Crosley Field (7-3) | 86-50 | Won 2 |
| » Starters: Fred Martin vs Ken Raffensberger | First | -- |
| » Defeated Reds (56-81), 7-4 | Crosley Field (8-3) | 87-50 | Won 3 |
| » Starters: Howie Pollet vs Harry Perkowski | First | -- |
| » Major-league debuts: Bill Howerton (Cardinals) |
| Tuesday, September 13 |
| » Defeated Giants (67-71), 1-0 | Sportsman's Park III (44-22) | 88-50 | Won 4 |
| » Starters: Dave Koslo vs Red Munger | First | -- |
| Wednesday, September 14 |
| » Defeated Giants (67-72), 9-3 | Sportsman's Park III (45-22) | 89-50 | Won 5 |
| » Starters: Monte Kennedy vs Harry Brecheen | First | -- |
| Friday, September 16 |
| » Defeated Braves (68-73), 7-5 | Sportsman's Park III (46-22) | 90-50 | Won 6 |
| » Starters: Warren Spahn vs Max Lanier | First | -- |
| Future Cardinal Mike Garman is born in Caldwell, ID. |
| Saturday, September 17 |
| » Lost to Braves (69-73), 4-2 | Sportsman's Park III (46-23) | 90-51 | |
| » Starters: Bill Voiselle vs Al Brazle | First | -- |
| Sunday, September 18 |
| » Defeated Phillies (76-68), 15-3 | Sportsman's Park III (47-23) | 91-51 | |
| » Starters: Robin Roberts vs Red Munger | First | -- |
| Monday, September 19 |
| » Lost to Phillies (77-68), 4-3 | Sportsman's Park III (47-24) | 91-52 | |
| » Starters: Jocko Thompson vs Howie Pollet | First | -- |
| Tuesday, September 20 |
| » Defeated Phillies (77-69), 7-5 | Sportsman's Park III (48-24) | 92-52 | |
| » Starters: Ken Heintzelman vs Fred Martin | First | -- |
| Wednesday, September 21 |
| » Defeated Dodgers (91-55), 1-0 | Sportsman's Park III (49-24) | 93-52 | Won 2 |
| » Starters: Don Newcombe vs Max Lanier | First | -- |
| » Lost to Dodgers (92-55), 5-0 | Sportsman's Park III (49-25) | 93-53 | |
| » Starters: Preacher Roe vs Harry Brecheen | First | -- |
| Thursday, September 22 |
| » Lost to Dodgers (93-55), 19-6 | Sportsman's Park III (49-26) | 93-54 | Lost 2 |
| » Starters: Joe Hatten vs Red Munger | First | -- |
| » Major-league debuts: Steve Bilko (Cardinals) |
| Friday, September 23 |
| » Major-league debuts: Wally Hood (Yankees) |
| Saturday, September 24 |
| » Defeated Cubs (59-90), 3-2 | Sportsman's Park III (50-26) | 94-54 | |
| » Starters: Bob Rush vs Gerry Staley | First | -- |
| Sunday, September 25 |
| » Defeated Cubs (59-91), 6-1 | Sportsman's Park III (51-26) | 95-54 | Won 2 |
| » Starters: Johnny Schmitz vs Harry Brecheen | First | -- |
| Tuesday, September 27 |
| » Lost to Pirates (68-82), 6-4 | Forbes Field (4-6) | 95-55 | |
| » Starters: Red Munger vs Bill Werle | First | -- |
| Wednesday, September 28 |
| Future Cardinal |
