| Monday, January 5 |
| Future Indian Bill Laxton is born in Camden, NJ. |
| Friday, January 23 |
| Former Indian Frank Doljack dies in Cleveland, OH at the age of 41. |
| Thursday, March 4 |
| Future Indian Leron Lee is born in Bakersfield, CA. |
| Monday, April 19 |
| » Major-league debuts: Monty Basgall and Ed Fitz Gerald (Pirates) |
| Tuesday, April 20 |
| » Defeated Browns (0-1), 4-0 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Fred Sanford vs Bob Feller | Second | ½ out |
| Wednesday, April 21 |
| » Major-league debuts: Jim Delsing (White Sox) |
| Thursday, April 22 |
| » Major-league debuts: Howie Judson (White Sox) |
| Friday, April 23 |
| » Defeated Tigers (3-1), 8-2 | Tiger Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Bob Lemon vs Fred Hutchinson | First | -- |
| Saturday, April 24 |
| » Defeated Tigers (3-2), 4-1 | Tiger Stadium (2-0) | 3-0 | Won 3 |
| » Starters: Bob Feller vs Art Houtteman | First | -- |
| Sunday, April 25 |
| » Defeated Tigers (3-3), 7-4 | Tiger Stadium (3-0) | 4-0 | Won 4 |
| » Starters: Al Gettel vs Hal Newhouser | First | -- |
| » Major-league debuts: Ray Murray (Indians) |
| Monday, April 26 |
| » Defeated White Sox (1-6), 12-11 | Comiskey Park I (1-0) | 5-0 | Won 5 |
| » Starters: Don Black vs Howie Judson | First | -- |
| » Major-league debuts: Bill Kennedy (Indians) |
| Wednesday, April 28 |
| » Major-league debuts: Ned Garver and Ken Wood (Browns) |
| Thursday, April 29 |
| » Defeated Browns (4-4), 5-2 | Sportsman's Park III (1-0) | 6-0 | Won 6 |
| » Starters: Bob Lemon vs Cliff Fannin | First | -- |
| Saturday, May 1 |
| » Lost to Tigers (5-7), 10-3 | Cleveland Stadium (1-1) | 6-1 | |
| » Starters: Dizzy Trout vs Bob Feller | First | -- |
| Sunday, May 2 |
| » Lost to Tigers (6-7), 4-2 | Cleveland Stadium (1-2) | 6-2 | Lost 2 |
| » Starters: Fred Hutchinson vs Bob Lemon | First | -- |
| » Major-league debuts: Joe Tipton (Indians) |
| Tuesday, May 4 |
| » Lost to Athletics (8-5), 8-6 | Shibe Park (0-1) | 6-3 | Lost 3 |
| » Starters: Bob Muncrief vs Phil Marchildon | First | -- |
| Thursday, May 6 |
| » Lost to Athletics (9-5), 8-5 | Shibe Park (0-2) | 6-4 | Lost 4 |
| » Starters: Bob Feller vs Dick Fowler | Third | 2 out |
| Friday, May 7 |
| » Defeated Senators (7-8), 8-0 | Griffith Stadium (1-0) | 7-4 | |
| » Starters: Bob Lemon vs Mickey Haefner | Second | 1½ out |
| Saturday, May 8 |
| » Defeated Senators (7-9), 6-1 | Griffith Stadium (2-0) | 8-4 | Won 2 |
| » Starters: Gene Bearden vs Sid Hudson | Second | 1½ out |
| Sunday, May 9 |
| » Defeated Red Sox (7-9), 4-1 | Fenway Park (1-0) | 9-4 | Won 3 |
| » Starters: Bob Feller vs Joe Dobson | First | -- |
| » Defeated Red Sox (7-10), 9-5 | Fenway Park (2-0) | 10-4 | Won 4 |
| » Starters: Don Black vs Ellis Kinder | First | -- |
| Monday, May 10 |
| » Defeated Red Sox (7-11), 12-7 | Fenway Park (3-0) | 11-4 | Won 5 |
| » Starters: Al Gettel vs Dave Ferriss | First | -- |
| Tuesday, May 11 |
| » Lost to Yankees (12-6), 4-1 | Yankee Stadium (0-1) | 11-5 | |
| » Starters: Bob Lemon vs Allie Reynolds | Second | 1 out |
| Friday, May 14 |
| Future Indian Dave LaRoche is born in Colorado Springs, CO. |
| Saturday, May 15 |
| » Defeated White Sox (3-15), 7-1 | Cleveland Stadium (2-2) | 12-5 | |
| » Starters: Joe Haynes vs Bob Feller | Second | 2½ out |
| Sunday, May 16 |
| » Lost to White Sox (4-15), 6-4 | Cleveland Stadium (2-3) | 12-6 | |
| » Starters: Bill Wight vs Bob Lemon | Second | 1½ out |
| » Defeated White Sox (4-16), 9-2 | Cleveland Stadium (3-3) | 13-6 | |
| » Starters: Orval Grove vs Bill Kennedy | Second | 1½ out |
| Tuesday, May 18 |
| » Defeated Athletics (16-7), 6-1 | Cleveland Stadium (4-3) | 14-6 | Won 2 |
| » Starters: Lou Brissie vs Gene Bearden | First | -- |
| » Major-league debuts: Billy DeMars (Athletics) |
| Wednesday, May 19 |
| » Defeated Athletics (16-8), 6-1 | Cleveland Stadium (5-3) | 15-6 | Won 3 |
| » Starters: Bill Dietrich vs Bob Feller | First | -- |
| Thursday, May 20 |
| » Defeated Red Sox (11-14), 13-4 | Cleveland Stadium (6-3) | 16-6 | Won 4 |
| » Starters: Mickey Harris vs Bob Lemon | First | -- |
| Friday, May 21 |
| » Lost to Red Sox (12-14), 11-5 | Cleveland Stadium (6-4) | 16-7 | |
| » Starters: Joe Dobson vs Bill Kennedy | First | -- |
| Saturday, May 22 |
| » Defeated Red Sox (12-15), 7-0 | Cleveland Stadium (7-4) | 17-7 | |
| » Starters: Jack Kramer vs Gene Bearden | First | -- |
| Sunday, May 23 |
| » Lost to Yankees (17-10), 6-5 | Cleveland Stadium (7-5) | 17-8 | |
| » Starters: Allie Reynolds vs Bob Feller | First | -- |
| » Defeated Yankees (17-11), 5-1 | Cleveland Stadium (8-5) | 18-8 | |
| » Starters: Ed Lopat vs Don Black | First | -- |
| Tuesday, May 25 |
| » Defeated Senators (12-18), 4-0 | Cleveland Stadium (9-5) | 19-8 | Won 2 |
| » Starters: Mickey Haefner vs Bob Lemon | First | -- |
| Wednesday, May 26 |
| » Lost to Senators (13-18), 2-0 | Cleveland Stadium (9-6) | 19-9 | |
| » Starters: Sid Hudson vs Gene Bearden | First | -- |
| Friday, May 28 |
| » Defeated White Sox (7-23), 2-0 | Comiskey Park I (2-0) | 20-9 | |
| » Starters: Don Black vs Joe Haynes | Second | 2 out |
| Saturday, May 29 |
| » Defeated White Sox (7-24), 4-0 | Comiskey Park I (3-0) | 21-9 | Won 2 |
| » Starters: Bob Lemon vs Bill Wight | Second | 2 out |
| Sunday, May 30 |
| » Lost to White Sox (8-24), 4-2 | Comiskey Park I (3-1) | 21-10 | |
| » Starters: Bob Feller vs Glen Moulder | Second | 2 out |
| » Defeated White Sox (8-25), 13-8 | Comiskey Park I (4-1) | 22-10 | |
| » Starters: Bill Kennedy vs Bob Gillespie | Second | 2 out |
| Monday, May 31 |
| » Defeated Browns (15-17), 8-3 | Cleveland Stadium (10-6) | 23-10 | Won 2 |
| » Starters: Ray Shore vs Gene Bearden | Second | 2 out |
| » Lost to Browns (16-17), 6-0 | Cleveland Stadium (10-7) | 23-11 | |
| » Starters: Cliff Fannin vs Bob Muncrief | Second | 2 out |
| Wednesday, June 2 |
| » Lost to Senators (19-21), 2-1 | Griffith Stadium (2-1) | 23-12 | Lost 2 |
| » Starters: Bob Lemon vs Ray Scarborough | First | -- |
| Friday, June 4 |
| » Defeated Senators (19-22), 5-0 | Griffith Stadium (3-1) | 24-12 | |
| » Starters: Bob Feller vs Mickey Haefner | First | -- |
| Saturday, June 5 |
| » Defeated Athletics (27-15), 7-3 | Shibe Park (1-2) | 25-12 | Won 2 |
| » Starters: Gene Bearden vs Joe Coleman | First | -- |
| Sunday, June 6 |
| » Defeated Athletics (27-16), 5-3 | Shibe Park (2-2) | 26-12 | Won 3 |
| » Starters: Bob Lemon vs Phil Marchildon | First | -- |
| » Defeated Athletics (27-17), 11-1 | Shibe Park (3-2) | 27-12 | Won 4 |
| » Starters: Steve Gromek vs Dick Fowler | First | -- |
| Tuesday, June 8 |
| » Defeated Red Sox (20-25), 2-0 | Fenway Park (4-0) | 28-12 | Won 5 |
| » Starters: Gene Bearden vs Mel Parnell | First | -- |
| Thursday, June 10 |
| » Lost to Red Sox (21-25), 15-7 | Fenway Park (4-1) | 28-13 | |
| » Starters: Bob Feller vs Joe Dobson | First | -- |
| Friday, June 11 |
| » Defeated Yankees (27-19), 10-8 | Yankee Stadium (1-1) | 29-13 | |
| » Starters: Bob Lemon vs Vic Raschi | First | -- |
| Saturday, June 12 |
| » Defeated Yankees (27-20), 7-5 | Yankee Stadium (2-1) | 30-13 | Won 2 |
| » Starters: Gene Bearden vs Allie Reynolds | First | -- |
| » Defeated Yankees (27-21), 9-4 | Yankee Stadium (3-1) | 31-13 | Won 3 |
| » Starters: Bob Muncrief vs Spec Shea | First | -- |
| Sunday, June 13 |
| » Lost to Yankees (28-21), 5-3 | Yankee Stadium (3-2) | 31-14 | |
| » Starters: Bob Feller vs Ed Lopat | First | -- |
| Tuesday, June 15 |
| » Lost to Red Sox (23-26), 7-3 | Cleveland Stadium (10-8) | 31-15 | Lost 2 |
| » Starters: Mel Parnell vs Bob Lemon | First | -- |
| Wednesday, June 16 |
| » Lost to Red Sox (24-26), 7-4 | Cleveland Stadium (10-9) | 31-16 | Lost 3 |
| » Starters: Joe Dobson vs Bob Feller | First | -- |
| Thursday, June 17 |
| » Lost to Red Sox (25-26), 8-6 | Cleveland Stadium (10-10) | 31-17 | Lost 4 |
| » Starters: Denny Galehouse vs Don Black | First | -- |
| Friday, June 18 |
| » Lost to Athletics (33-22), 5-4 | Cleveland Stadium (10-11) | 31-18 | Lost 5 |
| » Starters: Dick Fowler vs Gene Bearden | First | -- |
| Saturday, June 19 |
| » Defeated Athletics (33-23), 4-0 | Cleveland Stadium (11-11) | 32-18 | |
| » Starters: Bill McCahan vs Bob Muncrief | First | -- |
| Sunday, June 20 |
| » Defeated Athletics (33-24), 4-3 | Cleveland Stadium (12-11) | 33-18 | Won 2 |
| » Starters: Joe Coleman vs Bob Feller | First | -- |
| » Defeated Athletics (33-25), 10-0 | Cleveland Stadium (13-11) | 34-18 | Won 3 |
| » Starters: Phil Marchildon vs Bob Lemon | First | -- |
| Monday, June 21 |
| » Lost to Yankees (33-23), 13-2 | Cleveland Stadium (13-12) | 34-19 | |
| » Starters: Allie Reynolds vs Gene Bearden | First | -- |
| Tuesday, June 22 |
| » Defeated Yankees (33-24), 5-2 | Cleveland Stadium (14-12) | 35-19 | |
| » Starters: Spec Shea vs Sam Zoldak | First | -- |
| Wednesday, June 23 |
| » Lost to Yankees (34-24), 5-1 | Cleveland Stadium (14-13) | 35-20 | |
| » Starters: Ed Lopat vs Don Black | First | -- |
| Thursday, June 24 |
| » Lost to Yankees (35-24), 4-0 | Cleveland Stadium (14-14) | 35-21 | Lost 2 |
| » Starters: Vic Raschi vs Bob Feller | First | -- |
| Friday, June 25 |
| » Lost to Senators (28-32), 3-2 | Cleveland Stadium (14-15) | 35-22 | Lost 3 |
| » Starters: Early Wynn vs Bob Lemon | First | -- |
| Saturday, June 26 |
| » Defeated Senators (28-33), 5-0 | Cleveland Stadium (15-15) | 36-22 | |
| » Starters: Sid Hudson vs Bob Muncrief | First | -- |
| Sunday, June 27 |
| » Lost to Senators (29-33), 5-2 | Cleveland Stadium (15-16) | 36-23 | |
| » Starters: Ray Scarborough vs Gene Bearden | First | -- |
| » Defeated Senators (29-34), 4-1 | Cleveland Stadium (16-16) | 37-23 | |
| » Starters: Mickey Haefner vs Sam Zoldak | First | -- |
| Tuesday, June 29 |
| » Defeated Tigers (29-33), 6-2 | Tiger Stadium (4-0) | 38-23 | Won 2 |
| » Starters: Bob Feller vs Hal Newhouser | First | -- |
| Wednesday, June 30 |
| » Defeated Tigers (29-34), 2-0 | Tiger Stadium (5-0) | 39-23 | Won 3 |
| » Starters: Bob Lemon vs Art Houtteman | First | -- |
| Thursday, July 1 |
| » Lost to Tigers (30-34), 9-5 | Tiger Stadium (5-1) | 39-24 | |
| » Starters: Bob Muncrief vs Fred Hutchinson | First | -- |
| Friday, July 2 |
| » Defeated Browns (25-39), 8-6 | Sportsman's Park III (2-0) | 40-24 | |
| » Starters: Don Black vs Bill Kennedy | First | -- |
| Saturday, July 3 |
| » Defeated Browns (25-40), 8-2 | Sportsman's Park III (3-0) | 41-24 | Won 2 |
| » Starters: Bob Feller vs Ned Garver | First | -- |
| Monday, July 5 |
| » Defeated Tigers (32-37), 6-3 | Cleveland Stadium (17-16) | 42-24 | Won 3 |
| » Starters: Art Houtteman vs Bob Lemon | First | -- |
| » Lost to Tigers (33-37), 7-5 | Cleveland Stadium (17-17) | 42-25 | |
| » Starters: Fred Hutchinson vs Sam Zoldak | First | -- |
| Tuesday, July 6 |
| » Lost to Tigers (34-37), 9-0 | Cleveland Stadium (17-18) | 42-26 | Lost 2 |
| » Starters: Dizzy Trout vs Bob Muncrief | First | -- |
| Wednesday, July 7 |
| » Defeated White Sox (23-45), 10-2 | Cleveland Stadium (18-18) | 43-26 | |
| » Starters: Earl Caldwell vs Bob Feller | First | -- |
| Thursday, July 8 |
| » Defeated White Sox (23-46), 14-1 | Cleveland Stadium (19-18) | 44-26 | Won 2 |
| » Starters: Al Gettel vs Gene Bearden | First | -- |
| Friday, July 9 |
| » Lost to Browns (27-44), 5-3 | Cleveland Stadium (19-19) | 44-27 | |
| » Starters: Fred Sanford vs Bob Lemon | First | -- |
| Saturday, July 10 |
| Future Indian Rich Hand is born in Bellevue, WA. |
| Sunday, July 11 |
| » Lost to Browns (28-44), 3-2 | Cleveland Stadium (19-20) | 44-28 | Lost 2 |
| » Starters: Cliff Fannin vs Bob Feller | First | -- |
| » Defeated Browns (28-45), 5-0 | Cleveland Stadium (20-20) | 45-28 | |
| » Starters: Ray Shore vs Bob Lemon | First | -- |
| Thursday, July 15 |
| » Defeated Athletics (48-33), 6-1 | Shibe Park (4-2) | 46-28 | Won 2 |
| » Starters: Steve Gromek vs Phil Marchildon | First | -- |
| » Defeated Athletics (48-34), 8-5 | Shibe Park (5-2) | 47-28 | Won 3 |
| » Starters: Bob Lemon vs Dick Fowler | First | -- |
| Friday, July 16 |
| » Lost to Athletics (49-34), 10-5 | Shibe Park (5-3) | 47-29 | |
| » Starters: Bob Feller vs Lou Brissie | First | -- |
| Saturday, July 17 |
| » Lost to Athletics (50-34), 5-0 | Shibe Park (5-4) | 47-30 | Lost 2 |
| » Starters: Sam Zoldak vs Joe Coleman | First | -- |
| Sunday, July 18 |
| » Defeated Senators (35-45), 2-1 | Griffith Stadium (4-1) | 48-30 | |
| » Starters: Gene Bearden vs Early Wynn | First | -- |
| » Defeated Senators (35-46), 6-4 | Griffith Stadium (5-1) | 49-30 | Won 2 |
| » Starters: Bob Feller vs Mickey Haefner | First | -- |
| Monday, July 19 |
| » Defeated Senators (35-47), 7-6 | Griffith Stadium (6-1) | 50-30 | Won 3 |
| » Starters: Bob Lemon vs Forrest Thompson | First | -- |
| Tuesday, July 20 |
| » Lost to Senators (36-47), 2-1 | Griffith Stadium (6-2) | 50-31 | |
| » Starters: Don Black vs Ray Scarborough | First | -- |
| Wednesday, July 21 |
| » Lost to Yankees (48-35), 7-3 | Yankee Stadium (3-3) | 50-32 | Lost 2 |
| » Starters: Bob Muncrief vs Ed Lopat | First | -- |
| » Defeated Yankees (48-36), 12-8 | Yankee Stadium (4-3) | 51-32 | |
| » Starters: Steve Gromek vs Frank Hiller | First | -- |
| Thursday, July 22 |
| » Lost to Yankees (49-36), 6-5 | Yankee Stadium (4-4) | 51-33 | |
| » Starters: Bob Feller vs Vic Raschi | First | -- |
| Saturday, July 24 |
| » Lost to Red Sox (52-36), 6-5 | Fenway Park (4-2) | 51-34 | Lost 2 |
| » Starters: Bob Lemon vs Jack Kramer | Third | 3 out |
| » Lost to Red Sox (53-36), 2-1 | Fenway Park (4-3) | 51-35 | Lost 3 |
| » Starters: Sam Zoldak vs Mel Parnell | Third | 3 out |
| Sunday, July 25 |
| » Lost to Red Sox (54-36), 3-0 | Fenway Park (4-4) | 51-36 | Lost 4 |
| » Starters: Steve Gromek vs Joe Dobson | Third | 1½ out |
| Tuesday, July 27 |
| » Defeated Athletics (56-39), 10-5 | Cleveland Stadium (21-20) | 52-36 | |
| » Starters: Lou Brissie vs Bob Feller | Second | 1½ out |
| Wednesday, July 28 |
| » Lost to Athletics (57-39), 4-3 | Cleveland Stadium (21-21) | 52-37 | |
| » Starters: Dick Fowler vs Bob Lemon | Third | 1½ out |
| Friday, July 30 |
| » Lost to Red Sox (57-37), 8-7 | Cleveland Stadium (21-22) | 52-38 | Lost 2 |
| » Starters: Mel Parnell vs Gene Bearden | Third | 3 out |
| Saturday, July 31 |
| » Defeated Red Sox (57-38), 10-9 | Cleveland Stadium (22-22) | 53-38 | |
| » Starters: Joe Dobson vs Bob Feller | Third | 2 out |
| Sunday, August 1 |
| » Defeated Red Sox (57-39), 12-2 | Cleveland Stadium (23-22) | 54-38 | Won 2 |
| » Starters: Ellis Kinder vs Bob Lemon | Second | 3 out |
| » Defeated Red Sox (57-40), 6-1 | Cleveland Stadium (24-22) | 55-38 | Won 3 |
| » Starters: Mickey Harris vs Sam Zoldak | Second | 3 out |
| Tuesday, August 3 |
| » Defeated Senators (41-56), 5-3 | Cleveland Stadium (25-22) | 56-38 | Won 4 |
| » Starters: Early Wynn vs Satchel Paige | First | -- |
| Wednesday, August 4 |
| Future Indian Johnny Grubb is born in Richmond, VA. |
| Thursday, August 5 |
| » Defeated Senators (41-57), 3-0 | Cleveland Stadium (26-22) | 57-38 | Won 5 |
| » Starters: Ray Scarborough vs Gene Bearden | First | -- |
| Friday, August 6 |
| » Defeated Yankees (58-40), 9-7 | Cleveland Stadium (27-22) | 58-38 | Won 6 |
| » Starters: Ed Lopat vs Bob Feller | First | -- |
| Saturday, August 7 |
| » Lost to Yankees (59-40), 5-0 | Cleveland Stadium (27-23) | 58-39 | |
| » Starters: Vic Raschi vs Bob Lemon | First | -- |
| Sunday, August 8 |
| » Defeated Yankees (59-41), 8-6 | Cleveland Stadium (28-23) | 59-39 | |
| » Starters: Spec Shea vs Sam Zoldak | First | -- |
| » Defeated Yankees (59-42), 2-1 | Cleveland Stadium (29-23) | 60-39 | Won 2 |
| » Starters: Bob Porterfield vs Steve Gromek | First | -- |
| » Major-league debuts: Bob Porterfield (Yankees) |
| Monday, August 9 |
| » Defeated Tigers (49-53), 6-2 | Tiger Stadium (6-1) | 61-39 | Won 3 |
| » Starters: Gene Bearden vs Fred Hutchinson | First | -- |
| Tuesday, August 10 |
| » Lost to Tigers (50-53), 7-3 | Tiger Stadium (6-2) | 61-40 | |
| » Starters: Bob Feller vs Ted Gray | First | -- |
| Wednesday, August 11 |
| » Defeated Browns (40-61), 7-5 | Sportsman's Park III (4-0) | 62-40 | |
| » Starters: Bob Lemon vs Bryan Stephens | Second | 2½ out |
| » Lost to Browns (41-61), 12-4 | Sportsman's Park III (4-1) | 62-41 | |
| » Starters: Bob Muncrief vs Bill Kennedy | Second | 2½ out |
| Thursday, August 12 |
| » Lost to Browns (42-61), 8-4 | Sportsman's Park III (4-2) | 62-42 | Lost 2 |
| » Starters: Sam Zoldak vs Joe Ostrowski | Second | 1½ out |
| » Defeated Browns (42-62), 26-3 | Sportsman's Park III (5-2) | 63-42 | |
| » Starters: Gene Bearden vs Fred Sanford | Second | 1½ out |
| Friday, August 13 |
| » Defeated White Sox (36-70), 5-0 | Comiskey Park I (5-1) | 64-42 | Won 2 |
| » Starters: Satchel Paige vs Randy Gumpert | First | -- |
| Saturday, August 14 |
| » Defeated White Sox (36-71), 4-2 | Comiskey Park I (6-1) | 65-42 | Won 3 |
| » Starters: Steve Gromek vs Al Gettel | First | -- |
| Sunday, August 15 |
| » Defeated White Sox (36-72), 6-2 | Comiskey Park I (7-1) | 66-42 | Won 4 |
| » Starters: Bob Feller vs Bill Wight | First | -- |
| » Defeated White Sox (36-73), 8-0 | Comiskey Park I (8-1) | 67-42 | Won 5 |
| » Starters: Bob Lemon vs Joe Haynes | First | -- |
| Tuesday, August 17 |
| » Defeated Browns (43-65), 8-0 | Cleveland Stadium (30-23) | 68-42 | Won 6 |
| » Starters: Bill Kennedy vs Gene Bearden | First | -- |
| Wednesday, August 18 |
| » Defeated Browns (43-66), 3-0 | Cleveland Stadium (31-23) | 69-42 | Won 7 |
| » Starters: Joe Ostrowski vs Sam Zoldak | First | -- |
| Friday, August 20 |
| » Defeated White Sox (36-75), 1-0 | Cleveland Stadium (32-23) | 70-42 | Won 8 |
| » Starters: Bill Wight vs Satchel Paige | First | -- |
| Saturday, August 21 |
| » Lost to White Sox (37-75), 3-2 | Cleveland Stadium (32-24) | 70-43 | |
| » Starters: Randy Gumpert vs Bob Lemon | First | -- |
| Future Indian John Ellis is born in New London, CT. |
| Sunday, August 22 |
| » Lost to White Sox (38-75), 8-1 | Cleveland Stadium (32-25) | 70-44 | Lost 2 |
| » Starters: Joe Haynes vs Bob Feller | First | -- |
| » Lost to White Sox (39-75), 4-3 | Cleveland Stadium (32-26) | 70-45 | Lost 3 |
| » Starters: Marino Pieretti vs Gene Bearden | First | -- |
| Tuesday, August 24 |
| » Lost to Red Sox (71-46), 9-8 | Fenway Park (4-5) | 70-46 | Lost 4 |
| » Starters: Satchel Paige vs Joe Dobson | Second | ½ out |
| Wednesday, August 25 |
| » Defeated Red Sox (71-47), 9-0 | Fenway Park (5-5) | 71-46 | |
| » Starters: Bob Lemon vs Denny Galehouse | First | -- |
| Thursday, August 26 |
| » Lost to Red Sox (72-47), 8-4 | Fenway Park (5-6) | 71-47 | |
| » Starters: Gene Bearden vs Mel Parnell | Second | ½ out |
| Friday, August 27 |
| » Defeated Yankees (70-48), 8-1 | Yankee Stadium (5-4) | 72-47 | |
| » Starters: Bob Feller vs Vic Raschi | Second | 1 out |
| » Lost to Yankees (71-48), 7-2 | Yankee Stadium (5-5) | 72-48 | |
| » Starters: Steve Gromek vs Allie Reynolds | Second | 1 out |
| Saturday, August 28 |
| » Lost to Yankees (72-48), 3-2 | Yankee Stadium (5-6) | 72-49 | Lost 2 |
| » Starters: Sam Zoldak vs Ed Lopat | Third | 2 out |
| Sunday, August 29 |
| » Defeated Senators (46-76), 6-0 | Griffith Stadium (7-2) | 73-49 | |
| » Starters: Bob Lemon vs Forrest Thompson | Third | 2 out |
| » Lost to Senators (47-76), 5-2 | Griffith Stadium (7-3) | 73-50 | |
| » Starters: Don Black vs Early Wynn | Third | 2 out |
| Monday, August 30 |
| » Defeated Senators (47-77), 10-1 | Griffith Stadium (8-3) | 74-50 | |
| » Starters: Satchel Paige vs Ray Scarborough | Third | 1½ out |
| Tuesday, August 31 |
| » Defeated Athletics (73-54), 6-1 | Shibe Park (6-4) | 75-50 | Won 2 |
| » Starters: Gene Bearden vs Dick Fowler | Third | 1½ out |
| Wednesday, September 1 |
| » Defeated Athletics (73-55), 8-1 | Shibe Park (7-4) | 76-50 | Won 3 |
| » Starters: Bob Feller vs Bill McCahan | Third | 1½ out |
| Friday, September 3 |
| » Defeated Browns (47-76), 7-0 | Sportsman's Park III (6-2) | 77-50 | Won 4 |
| » Starters: Bob Lemon vs Bill Kennedy | Third | 2 out |
| » Lost to Browns (48-76), 4-3 | Sportsman's Park III (6-3) | 77-51 | |
| » Starters: Sam Zoldak vs Joe Ostrowski | Third | 2 out |
| » Major-league debuts: Ray Boone (Indians) |
| Saturday, September 4 |
| » Lost to Browns (49-76), 4-3 | Sportsman's Park III (6-4) | 77-52 | Lost 2 |
| » Starters: Satchel Paige vs Ned Garver | Third | 3 out |
| Monday, September 6 |
| » Lost to White Sox (44-85), 3-1 | Comiskey Park I (8-2) | 77-53 | Lost 3 |
| » Starters: Gene Bearden vs Joe Haynes | Third | 4½ out |
| » Defeated White Sox (44-86), 1-0 | Comiskey Park I (9-2) | 78-53 | |
| » Starters: Bob Feller vs Randy Gumpert | Third | 4½ out |
| Wednesday, September 8 |
| » Defeated Tigers (62-65), 8-7 | Cleveland Stadium (33-26) | 79-53 | Won 2 |
| » Starters: Fred Hutchinson vs Bob Lemon | Third | 4½ out |
| Thursday, September 9 |
| » Defeated Tigers (62-66), 3-2 | Cleveland Stadium (34-26) | 80-53 | Won 3 |
| » Starters: Hal Newhouser vs Bob Feller | Third | 4½ out |
| Friday, September 10 |
| » Defeated Tigers (62-67), 10-1 | Cleveland Stadium (35-26) | 81-53 | Won 4 |
| » Starters: Dizzy Trout vs Gene Bearden | Third | 3½ out |
| Saturday, September 11 |
| » Defeated Browns (53-78), 4-1 | Cleveland Stadium (36-26) | 82-53 | Won 5 |
| » Starters: Cliff Fannin vs Steve Gromek | Third | 3½ out |
| » Defeated Browns (53-79), 9-1 | Cleveland Stadium (37-26) | 83-53 | Won 6 |
| » Starters: Al Gerheauser vs Bob Lemon | Third | 3½ out |
| Sunday, September 12 |
| » Defeated Browns (53-80), 6-4 | Cleveland Stadium (38-26) | 84-53 | Won 7 |
| » Starters: Karl Drews vs Satchel Paige | Third | 2½ out |
| » Tied Browns, 3-3 | Cleveland Stadium (38-26) | 84-53 | |
| » Starters: Blackie Schwamb vs Bob Feller | Third | 2½ out |
| Monday, September 13 |
| » Lost to Browns (54-80), 3-2 | Cleveland Stadium (38-27) | 84-54 | |
| » Starters: Bill Kennedy vs Don Black | Third | 3 out |
| Tuesday, September 14 |
| » Lost to Yankees (85-52), 6-5 | Cleveland Stadium (38-28) | 84-55 | Lost 2 |
| » Starters: Ed Lopat vs Bob Lemon | Third | 4 out |
| Wednesday, September 15 |
| » Major-league debuts: Joe Ginsberg (Tigers) |
| Thursday, September 16 |
| » Defeated Senators (49-93), 6-3 | Cleveland Stadium (39-28) | 85-55 | |
| » Starters: Sid Hudson vs Gene Bearden | Third | 2½ out |
| Friday, September 17 |
| » Defeated Senators (49-94), 4-1 | Cleveland Stadium (40-28) | 86-55 | Won 2 |
| » Starters: Walt Masterson vs Bob Feller | Third | 2½ out |
| Saturday, September 18 |
| » Defeated Senators (49-95), 10-1 | Cleveland Stadium (41-28) | 87-55 | Won 3 |
| » Starters: Early Wynn vs Sam Zoldak | Third | 2½ out |
| Sunday, September 19 |
| » Defeated Athletics (83-62), 5-3 | Cleveland Stadium (42-28) | 88-55 | Won 4 |
| » Starters: Carl Scheib vs Bob Lemon | Second | ½ out |
| » Defeated Athletics (83-63), 2-0 | Cleveland Stadium (43-28) | 89-55 | Won 5 |
| » Starters: Dick Fowler vs Steve Gromek | Second | ½ out |
| Monday, September 20 |
| » Defeated Athletics (83-64), 6-3 | Cleveland Stadium (44-28) | 90-55 | Won 6 |
| » Starters: Lou Brissie vs Gene Bearden | Second | ½ out |
| Wednesday, September 22 |
| » Defeated Red Sox (91-55), 5-2 | Cleveland Stadium (45-28) | 91-55 | Won 7 |
| » Starters: Joe Dobson vs Bob Feller | First | -- |
| Friday, September 24 |
| » Lost to Tigers (74-72), 4-3 | Tiger Stadium (6-3) | 91-56 | |
| » Starters: Bob Lemon vs Fred Hutchinson | First | -- |
| Saturday, September 25 |
| » Defeated Tigers (74-73), 9-3 | Tiger Stadium (7-3) | 92-56 | |
| » Starters: Gene Bearden vs Virgil Trucks | First | -- |
| Sunday, September 26 |
| » Defeated Tigers (74-74), 4-1 | Tiger Stadium (8-3) | 93-56 | Won 2 |
| » Starters: Bob Feller vs Hal Newhouser | First | -- |
| Tuesday, September 28 |
| » Defeated White Sox (49-99), 11-0 | Cleveland Stadium (46-28) | 94-56 | Won 3 |
| » Starters: Bill Wight vs Gene Bearden | First | -- |
| Wednesday, September 29 |
| » Defeated White Sox (49-100), 5-2 | Cleveland Stadium (47-28) | 95-56 | Won 4 |
| » Starters: Frank Papish vs Bob Feller | First | -- |
| Thursday, September 30 |
| Future Indian Rusty Torres is born in Aguadilla, P.R. |
| Friday, October 1 |
| » Lost to Tigers (77-75), 5-3 | Cleveland Stadium (47-29) | 95-57 | |
| » Starters: Virgil Trucks vs Bob Lemon | First | -- |
| Saturday, October 2 |
| » Defeated Tigers (77-76), 8-0 | Cleveland Stadium (48-29) | 96-57 | |
| » Starters: Lou Kretlow vs Gene Bearden | First | -- |
| Sunday, October 3 |
| » Lost to Tigers (78-76), 7-1 | Cleveland Stadium (48-30) | 96-58 | |
| » Starters: Hal Newhouser vs Bob Feller | First | -- |
| » Major-league debuts: Mike Garcia (Indians) |
| Monday, October 4 |
| » Defeated Red Sox (96-59), 8-3 | Fenway Park (6-6) | 97-58 | |
| » Starters: Gene Bearden vs Denny Galehouse | < |
