| Monday, January 19 |
| Future Cub Ken Frailing is born in Marion, WI. |
| Saturday, February 14 |
| Former Cub Three-Finger Brown dies in Terre Haute, IN at the age of 72. |
| Sunday, February 15 |
| Future Cub Ron Cey is born in Tacoma, WA. |
| Monday, April 19 |
| » Major-league debuts: Monty Basgall and Ed Fitz Gerald (Pirates) |
| Tuesday, April 20 |
| » Lost to Pirates (1-1), 3-2 | Forbes Field (0-1) | 0-1 | |
| » Starters: Russ Meyer vs Rip Sewell | Third | 1 out |
| » Major-league debuts: Hal Jeffcoat Roy Smalley and Rube Walker (Cubs) |
| Wednesday, April 21 |
| » Defeated Pirates (1-2), 6-3 | Forbes Field (1-1) | 1-1 | |
| » Starters: Hank Borowy vs Tiny Bonham | Second | 1 out |
| » Major-league debuts: Woody Main (Pirates) |
| Thursday, April 22 |
| » Lost to Pirates (2-2), 3-0 | Forbes Field (1-2) | 1-2 | |
| » Starters: Bob Rush vs Elmer Riddle | Third | 1 out |
| » Major-league debuts: Bob Rush (Cubs) |
| Friday, April 23 |
| » Lost to Cardinals (3-1), 1-0 | Wrigley Field (0-1) | 1-3 | Lost 2 |
| » Starters: Harry Brecheen vs Johnny Schmitz | Fifth | 2 out |
| Saturday, April 24 |
| » Defeated Cardinals (3-2), 6-2 | Wrigley Field (1-1) | 2-3 | |
| » Starters: Al Brazle vs Cliff Chambers | Third | 1 out |
| » Major-league debuts: Cliff Chambers (Cubs) Al Papai (Cardinals) |
| Sunday, April 25 |
| » Defeated Cardinals (3-3), 3-1 | Wrigley Field (2-1) | 3-3 | Won 2 |
| » Starters: Murry Dickson vs Russ Meyer | Third | 1½ out |
| Tuesday, April 27 |
| » Defeated Reds (4-5), 7-2 | Crosley Field (1-0) | 4-3 | Won 3 |
| » Starters: Dutch McCall vs Ewell Blackwell | Second | 2 out |
| Wednesday, April 28 |
| » Lost to Reds (5-5), 8-1 | Crosley Field (1-1) | 4-4 | |
| » Starters: Johnny Schmitz vs Johnny Vander Meer | Third | 2½ out |
| Thursday, April 29 |
| » Lost to Pirates (5-4), 4-2 | Wrigley Field (2-2) | 4-5 | Lost 2 |
| » Starters: Elmer Riddle vs Hank Borowy | Fifth | 2½ out |
| Friday, April 30 |
| » Lost to Pirates (6-4), 10-4 | Wrigley Field (2-3) | 4-6 | Lost 3 |
| » Starters: Rip Sewell vs Bob Rush | Eighth | 2½ out |
| » Major-league debuts: Ben Wade (Cubs) |
| Saturday, May 1 |
| » Lost to Cardinals (5-4), 4-0 | Sportsman's Park III (0-1) | 4-7 | Lost 4 |
| » Starters: Cliff Chambers vs Harry Brecheen | Seventh | 3 out |
| Sunday, May 2 |
| » Defeated Cardinals (5-5), 13-4 | Sportsman's Park III (1-1) | 5-7 | |
| » Starters: Russ Meyer vs Murry Dickson | Sixth | 3 out |
| Monday, May 3 |
| » Lost to Cardinals (6-5), 3-1 | Sportsman's Park III (1-2) | 5-8 | |
| » Starters: Johnny Schmitz vs Jim Hearn | Seventh | 3½ out |
| Wednesday, May 5 |
| » Lost to Phillies (7-8), 13-9 | Wrigley Field (2-4) | 5-9 | Lost 2 |
| » Starters: Schoolboy Rowe vs Dutch McCall | Eighth | 4½ out |
| Thursday, May 6 |
| » Major-league debuts: Bob Chesnes (Pirates) |
| Friday, May 7 |
| » Lost to Dodgers (8-7), 9-5 | Wrigley Field (2-5) | 5-10 | Lost 3 |
| » Starters: Joe Hatten vs Hank Borowy | Seventh | 4½ out |
| Saturday, May 8 |
| » Defeated Dodgers (8-8), 6-0 | Wrigley Field (3-5) | 6-10 | |
| » Starters: Lefty Sloat vs Johnny Schmitz | Eighth | 4½ out |
| Sunday, May 9 |
| » Defeated Giants (11-7), 2-0 | Wrigley Field (4-5) | 7-10 | Won 2 |
| » Starters: Dave Koslo vs Russ Meyer | Seventh | 4 out |
| Thursday, May 13 |
| » Lost to Braves (10-10), 2-0 | Wrigley Field (4-6) | 7-11 | |
| » Starters: Bill Voiselle vs Johnny Schmitz | Seventh | 4½ out |
| Friday, May 14 |
| » Defeated Reds (7-17), 1-0 | Wrigley Field (5-6) | 8-11 | |
| » Starters: Kent Peterson vs Russ Meyer | Seventh | 4 out |
| Future Cub Dave LaRoche is born in Colorado Springs, CO. |
| Saturday, May 15 |
| » Lost to Reds (8-17), 5-2 | Wrigley Field (5-7) | 8-12 | |
| » Starters: Herm Wehmeier vs Dutch McCall | Seventh | 4½ out |
| Future Cub Billy North is born in Seattle, WA. |
| Sunday, May 16 |
| » Lost to Reds (9-17), 13-11 | Wrigley Field (5-8) | 8-13 | Lost 2 |
| » Starters: Bucky Walters vs Cliff Chambers | Sixth | 5½ out |
| Tuesday, May 18 |
| » Defeated Phillies (13-12), 3-2 | Shibe Park (1-0) | 9-13 | |
| » Starters: Johnny Schmitz vs Curt Simmons | Seventh | 5½ out |
| Wednesday, May 19 |
| » Lost to Phillies (14-12), 2-1 | Shibe Park (1-1) | 9-14 | |
| » Starters: Cliff Chambers vs Dutch Leonard | Seventh | 6½ out |
| Thursday, May 20 |
| » Defeated Phillies (14-13), 5-3 | Shibe Park (2-1) | 10-14 | |
| » Starters: Russ Meyer vs Monk Dubiel | Seventh | 6½ out |
| Friday, May 21 |
| » Defeated Giants (14-11), 8-3 | Polo Grounds V (1-0) | 11-14 | Won 2 |
| » Starters: Hank Borowy vs Sheldon Jones | Sixth | 5½ out |
| Saturday, May 22 |
| » Lost to Giants (15-11), 11-0 | Polo Grounds V (1-1) | 11-15 | |
| » Starters: Bob Rush vs Ray Poat | Sixth | 6½ out |
| Sunday, May 23 |
| » Lost to Braves (15-13), 8-5 | Braves Field (0-1) | 11-16 | Lost 2 |
| » Starters: Cliff Chambers vs Bill Voiselle | Fifth | 8½ out |
| » Lost to Braves (16-13), 12-4 | Braves Field (0-2) | 11-17 | Lost 3 |
| » Starters: Dutch McCall vs Vern Bickford | Fifth | 8½ out |
| Wednesday, May 26 |
| » Defeated Dodgers (12-19), 4-1 | Ebbets Field (1-0) | 12-17 | |
| » Starters: Johnny Schmitz vs Willie Ramsdell | Fifth | 7 out |
| Former Cub Bill Sweeney dies in Cambridge, MA at the age of 63. |
| Thursday, May 27 |
| » Lost to Dodgers (13-19), 4-2 | Ebbets Field (1-1) | 12-18 | |
| » Starters: Russ Meyer vs Ralph Branca | Seventh | 8 out |
| Friday, May 28 |
| » Defeated Reds (13-21), 10-8 | Crosley Field (2-1) | 13-18 | |
| » Starters: Bob Chipman vs Howie Fox | Sixth | 7½ out |
| Saturday, May 29 |
| » Lost to Reds (14-21), 4-3 | Crosley Field (2-2) | 13-19 | |
| » Starters: Dutch McCall vs Johnny Vander Meer | Seventh | 7½ out |
| Sunday, May 30 |
| » Lost to Reds (15-21), 6-1 | Crosley Field (2-3) | 13-20 | Lost 2 |
| » Starters: Johnny Schmitz vs Kent Peterson | Eighth | 7½ out |
| » Lost to Reds (16-21), 8-3 | Crosley Field (2-4) | 13-21 | Lost 3 |
| » Starters: Emil Kush vs Herm Wehmeier | Eighth | 7½ out |
| Monday, May 31 |
| » Defeated Pirates (19-16), 4-3 | Wrigley Field (6-8) | 14-21 | |
| » Starters: Rip Sewell vs Russ Meyer | Eighth | 7 out |
| » Lost to Pirates (20-16), 4-2 | Wrigley Field (6-9) | 14-22 | |
| » Starters: Elmer Riddle vs Cliff Chambers | Eighth | 7 out |
| Wednesday, June 2 |
| » Defeated Phillies (19-20), 2-1 | Wrigley Field (7-9) | 15-22 | |
| » Starters: Dutch Leonard vs Dutch McCall | Eighth | 7 out |
| Thursday, June 3 |
| » Lost to Phillies (20-20), 4-3 | Wrigley Field (7-10) | 15-23 | |
| » Starters: Curt Simmons vs Bob Rush | Eighth | 7 out |
| Friday, June 4 |
| » Lost to Phillies (21-20), 7-2 | Wrigley Field (7-11) | 15-24 | Lost 2 |
| » Starters: Monk Dubiel vs Johnny Schmitz | Eighth | 8 out |
| Saturday, June 5 |
| » Lost to Phillies (22-20), 4-2 | Wrigley Field (7-12) | 15-25 | Lost 3 |
| » Starters: Schoolboy Rowe vs Cliff Chambers | Eighth | 8½ out |
| » Lost to Phillies (23-20), 6-5 | Wrigley Field (7-13) | 15-26 | Lost 4 |
| » Starters: Paul Erickson vs Ralph Hamner | Eighth | 8½ out |
| Sunday, June 6 |
| » Lost to Braves (20-19), 1-0 | Wrigley Field (7-14) | 15-27 | Lost 5 |
| » Starters: Johnny Sain vs Russ Meyer | Eighth | 9½ out |
| Monday, June 7 |
| » Lost to Braves (21-19), 9-5 | Wrigley Field (7-15) | 15-28 | Lost 6 |
| » Starters: Bill Voiselle vs Dutch McCall | Eighth | 10 out |
| Tuesday, June 8 |
| » Lost to Braves (22-19), 11-1 | Wrigley Field (7-16) | 15-29 | Lost 7 |
| » Starters: Vern Bickford vs Johnny Schmitz | Eighth | 10½ out |
| Wednesday, June 9 |
| » Defeated Giants (24-18), 8-7 | Wrigley Field (8-16) | 16-29 | |
| » Starters: Dave Koslo vs Hank Borowy | Eighth | 10½ out |
| » Lost to Giants (25-18), 5-1 | Wrigley Field (8-17) | 16-30 | |
| » Starters: Clint Hartung vs Cliff Chambers | Eighth | 10½ out |
| Thursday, June 10 |
| » Defeated Giants (25-19), 6-4 | Wrigley Field (9-17) | 17-30 | |
| » Starters: Thornton Lee vs Russ Meyer | Seventh | 9½ out |
| Friday, June 11 |
| » Defeated Giants (25-20), 3-1 | Wrigley Field (10-17) | 18-30 | Won 2 |
| » Starters: Andy Hansen vs Ralph Hamner | Seventh | 9 out |
| Sunday, June 13 |
| » Defeated Dodgers (21-25), 3-1 | Wrigley Field (11-17) | 19-30 | Won 3 |
| » Starters: Joe Hatten vs Johnny Schmitz | Seventh | 8½ out |
| Tuesday, June 15 |
| » Lost to Braves (28-21), 6-3 | Braves Field (0-3) | 19-31 | |
| » Starters: Russ Meyer vs Johnny Sain | Seventh | 9½ out |
| Wednesday, June 16 |
| » Defeated Braves (28-22), 8-5 | Braves Field (1-3) | 20-31 | |
| » Starters: Dutch McCall vs Bill Voiselle | Sixth | 8½ out |
| Thursday, June 17 |
| » Lost to Braves (29-22), 7-6 | Braves Field (1-4) | 20-32 | |
| » Starters: Ralph Hamner vs Warren Spahn | Eighth | 10½ out |
| » Lost to Braves (30-22), 8-7 | Braves Field (1-5) | 20-33 | Lost 2 |
| » Starters: Johnny Schmitz vs Vern Bickford | Eighth | 10½ out |
| Friday, June 18 |
| » Defeated Dodgers (23-27), 6-4 | Ebbets Field (2-1) | 21-33 | |
| » Starters: Hank Borowy vs Rex Barney | Eighth | 10½ out |
| Saturday, June 19 |
| » Defeated Dodgers (23-28), 5-2 | Ebbets Field (3-1) | 22-33 | Won 2 |
| » Starters: Bob Rush vs Harry Taylor | Eighth | 10½ out |
| Sunday, June 20 |
| » Defeated Dodgers (23-29), 6-3 | Ebbets Field (4-1) | 23-33 | Won 3 |
| » Starters: Russ Meyer vs Preacher Roe | Eighth | 11 out |
| Thursday, June 24 |
| » Lost to Giants (30-26), 3-2 | Polo Grounds V (1-2) | 23-34 | |
| » Starters: Johnny Schmitz vs Larry Jansen | Eighth | 9½ out |
| » Defeated Giants (30-27), 11-2 | Polo Grounds V (2-2) | 24-34 | |
| » Starters: Ralph Hamner vs Clint Hartung | Eighth | 9½ out |
| Friday, June 25 |
| » Lost to Phillies (29-32), 2-1 | Shibe Park (2-2) | 24-35 | |
| » Starters: Hank Borowy vs Dutch Leonard | Eighth | 10½ out |
| Saturday, June 26 |
| » Lost to Phillies (30-32), 3-2 | Shibe Park (2-3) | 24-36 | Lost 2 |
| » Starters: Bob Rush vs Schoolboy Rowe | Eighth | 10½ out |
| Sunday, June 27 |
| » Defeated Phillies (30-33), 6-2 | Shibe Park (3-3) | 25-36 | |
| » Starters: Russ Meyer vs Curt Simmons | Eighth | 11 out |
| » Lost to Phillies (31-33), 7-4 | Shibe Park (3-4) | 25-37 | |
| » Starters: Cliff Chambers vs Robin Roberts | Eighth | 11 out |
| Tuesday, June 29 |
| » Defeated Cardinals (35-27), 3-1 | Wrigley Field (12-17) | 26-37 | |
| » Starters: Harry Brecheen vs Johnny Schmitz | Eighth | 10 out |
| Wednesday, June 30 |
| » Defeated Cardinals (35-28), 9-1 | Wrigley Field (13-17) | 27-37 | Won 2 |
| » Starters: Jim Hearn vs Ralph Hamner | Eighth | 10 out |
| Thursday, July 1 |
| » Defeated Cardinals (35-29), 4-3 | Wrigley Field (14-17) | 28-37 | Won 3 |
| » Starters: Murry Dickson vs Bob Chipman | Eighth | 10 out |
| Former Cub Pete Knisely dies in Brownsville, PA at the age of 61. |
| Friday, July 2 |
| » Defeated Pirates (34-30), 5-1 | Forbes Field (2-2) | 29-37 | Won 4 |
| » Starters: Russ Meyer vs Bob Chesnes | Seventh | 10 out |
| Sunday, July 4 |
| » Lost to Pirates (35-30), 5-1 | Forbes Field (2-3) | 29-38 | |
| » Starters: Hank Borowy vs Rip Sewell | Eighth | 10½ out |
| » Lost to Pirates (36-30), 6-2 | Forbes Field (2-4) | 29-39 | Lost 2 |
| » Starters: Bob Rush vs Elmer Riddle | Eighth | 10½ out |
| Future Cub Wayne Nordhagen is born in Thief River Falls, MN. |
| Monday, July 5 |
| » Lost to Cardinals (37-31), 6-3 | Sportsman's Park III (1-3) | 29-40 | Lost 3 |
| » Starters: Johnny Schmitz vs Murry Dickson | Eighth | 11½ out |
| » Lost to Cardinals (38-31), 5-2 | Sportsman's Park III (1-4) | 29-41 | Lost 4 |
| » Starters: Ralph Hamner vs Jim Hearn | Eighth | 11½ out |
| Tuesday, July 6 |
| » Defeated Cardinals (38-32), 12-10 | Sportsman's Park III (2-4) | 30-41 | |
| » Starters: Russ Meyer vs Red Munger | Eighth | 11½ out |
| Wednesday, July 7 |
| » Lost to Reds (34-39), 10-3 | Wrigley Field (14-18) | 30-42 | |
| » Starters: Ken Raffensberger vs Bob Chipman | Eighth | 11½ out |
| Thursday, July 8 |
| » Lost to Reds (35-39), 4-0 | Wrigley Field (14-19) | 30-43 | Lost 2 |
| » Starters: Ewell Blackwell vs Bob Rush | Eighth | 12½ out |
| Friday, July 9 |
| » Defeated Pirates (39-33), 2-1 | Wrigley Field (15-19) | 31-43 | |
| » Starters: Elmer Riddle vs Ralph Hamner | Eighth | 12½ out |
| Saturday, July 10 |
| » Defeated Pirates (39-34), 4-2 | Wrigley Field (16-19) | 32-43 | Won 2 |
| » Starters: Rip Sewell vs Johnny Schmitz | Eighth | 12½ out |
| Sunday, July 11 |
| » Defeated Pirates (39-35), 1-0 | Wrigley Field (17-19) | 33-43 | Won 3 |
| » Starters: Tiny Bonham vs Russ Meyer | Eighth | 12½ out |
| Thursday, July 15 |
| » Lost to Braves (47-31), 2-1 | Wrigley Field (17-20) | 33-44 | |
| » Starters: Johnny Sain vs Ralph Hamner | Eighth | 13½ out |
| » Tied Braves, 1-1 | Wrigley Field (17-20) | 33-44 | |
| » Starters: Bill Voiselle vs Bob Rush | Eighth | 13½ out |
| Friday, July 16 |
| » Lost to Braves (48-31), 12-10 | Wrigley Field (17-21) | 33-45 | Lost 2 |
| » Starters: Vern Bickford vs Russ Meyer | Eighth | 14½ out |
| Saturday, July 17 |
| » Defeated Braves (48-32), 4-1 | Wrigley Field (18-21) | 34-45 | |
| » Starters: Warren Spahn vs Ralph Hamner | Eighth | 13½ out |
| Sunday, July 18 |
| » Defeated Phillies (38-44), 3-2 | Wrigley Field (19-21) | 35-45 | Won 2 |
| » Starters: Robin Roberts vs Johnny Schmitz | Eighth | 14½ out |
| » Lost to Phillies (39-44), 6-4 | Wrigley Field (19-22) | 35-46 | |
| » Starters: Schoolboy Rowe vs Russ Meyer | Eighth | 14½ out |
| Monday, July 19 |
| » Lost to Phillies (40-44), 5-4 | Wrigley Field (19-23) | 35-47 | Lost 2 |
| » Starters: Dutch Leonard vs Doyle Lade | Seventh | 14½ out |
| Tuesday, July 20 |
| » Lost to Dodgers (41-38), 5-0 | Wrigley Field (19-24) | 35-48 | Lost 3 |
| » Starters: Rex Barney vs Bob Rush | Eighth | 14½ out |
| Wednesday, July 21 |
| » Lost to Dodgers (42-38), 9-3 | Wrigley Field (19-25) | 35-49 | Lost 4 |
| » Starters: Ralph Branca vs Ralph Hamner | Eighth | 16 out |
| » Lost to Dodgers (43-38), 7-1 | Wrigley Field (19-26) | 35-50 | Lost 5 |
| » Starters: Joe Hatten vs Dutch McCall | Eighth | 16 out |
| Thursday, July 22 |
| » Defeated Dodgers (43-39), 6-3 | Wrigley Field (20-26) | 36-50 | |
| » Starters: Hank Behrman vs Johnny Schmitz | Seventh | 15½ out |
| Friday, July 23 |
| » Lost to Giants (42-41), 5-0 | Wrigley Field (20-27) | 36-51 | |
| » Starters: Larry Jansen vs Russ Meyer | Eighth | 15½ out |
| Saturday, July 24 |
| » Defeated Giants (42-42), 3-1 | Wrigley Field (21-27) | 37-51 | |
| » Starters: Clint Hartung vs Doyle Lade | Eighth | 15 out |
| » Lost to Giants (43-42), 3-0 | Wrigley Field (21-28) | 37-52 | |
| » Starters: Dave Koslo vs Bob Rush | Eighth | 15 out |
| Future Cub Mike Adams is born in Cincinnati, OH. |
| Sunday, July 25 |
| » Defeated Giants (43-43), 6-3 | Wrigley Field (22-28) | 38-52 | |
| » Starters: Ray Poat vs Ralph Hamner | Eighth | 14½ out |
| Tuesday, July 27 |
| » Defeated Phillies (43-49), 3-2 | Shibe Park (4-4) | 39-52 | Won 2 |
| » Starters: Johnny Schmitz vs Dutch Leonard | Eighth | 14½ out |
| Former Cub Joe Tinker dies in Orlando, FL at the age of 69. |
| Wednesday, July 28 |
| » Lost to Phillies (44-49), 9-4 | Shibe Park (4-5) | 39-53 | |
| » Starters: Russ Meyer vs Blix Donnelly | Seventh | 15½ out |
| Thursday, July 29 |
| » Lost to Phillies (45-49), 7-4 | Shibe Park (4-6) | 39-54 | Lost 2 |
| » Starters: Doyle Lade vs Schoolboy Rowe | Eighth | 16½ out |
| Friday, July 30 |
| » Lost to Giants (48-43), 9-1 | Polo Grounds V (2-3) | 39-55 | Lost 3 |
| » Starters: Ralph Hamner vs Sheldon Jones | Eighth | 16½ out |
| Saturday, July 31 |
| » Lost to Giants (49-43), 14-9 | Polo Grounds V (2-4) | 39-56 | Lost 4 |
| » Starters: Bob Rush vs Larry Jansen | Eighth | 18 out |
| » Lost to Giants (50-43), 6-3 | Polo Grounds V (2-5) | 39-57 | Lost 5 |
| » Starters: Dutch McCall vs Monte Kennedy | Eighth | 18 out |
| Monday, August 2 |
| » Defeated Dodgers (48-44), 4-2 | Ebbets Field (5-1) | 40-57 | |
| » Starters: Johnny Schmitz vs Rex Barney | Eighth | 16½ out |
| Wednesday, August 4 |
| » Lost to Dodgers (49-44), 5-4 | Ebbets Field (5-2) | 40-58 | |
| » Starters: Russ Meyer vs Joe Hatten | Eighth | 16 out |
| Thursday, August 5 |
| » Lost to Dodgers (50-44), 6-4 | Ebbets Field (5-3) | 40-59 | Lost 2 |
| » Starters: Ralph Hamner vs Carl Erskine | Eighth | 17 out |
| Friday, August 6 |
| » Defeated Braves (57-43), 5-4 | Braves Field (2-5) | 41-59 | |
| » Starters: Cliff Chambers vs Vern Bickford | Eighth | 16 out |
| Saturday, August 7 |
| » Lost to Braves (58-43), 6-3 | Braves Field (2-6) | 41-60 | |
| » Starters: Johnny Schmitz vs Johnny Sain | Eighth | 17 out |
| Sunday, August 8 |
| » Lost to Braves (59-43), 6-3 | Braves Field (2-7) | 41-61 | Lost 2 |
| » Starters: Hank Borowy vs Bill Voiselle | Eighth | 18 out |
| Monday, August 9 |
| Future Cub Bill Campbell is born in Highland Park, MI. |
| Tuesday, August 10 |
| » Lost to Pirates (49-47), 5-1 | Forbes Field (2-5) | 41-62 | Lost 3 |
| » Starters: Bob Rush vs Hal Gregg | Eighth | 18 out |
| Wednesday, August 11 |
| » Lost to Pirates (50-47), 4-2 | Forbes Field (2-6) | 41-63 | Lost 4 |
| » Starters: Ralph Hamner vs Rip Sewell | Eighth | 19 out |
| Friday, August 13 |
| » Defeated Reds (45-61), 10-4 | Crosley Field (3-4) | 42-63 | |
| » Starters: Johnny Schmitz vs Ewell Blackwell | Eighth | 18½ out |
| Saturday, August 14 |
| Former Cub Phil Collins dies in Chicago, IL at the age of 47. |
| Sunday, August 15 |
| » Defeated Reds (45-62), 7-6 | Crosley Field (4-4) | 43-63 | Won 2 |
| » Starters: Russ Meyer vs Herm Wehmeier | Eighth | 18½ out |
| » Lost to Reds (46-62), 5-0 | Crosley Field (4-5) | 43-64 | |
| » Starters: Dutch McCall vs Ken Raffensberger | Eighth | 18½ out |
| Monday, August 16 |
| » Lost to Cardinals (59-49), 9-7 | Wrigley Field (22-29) | 43-65 | Lost 2 |
| » Starters: Howie Pollet vs Ralph Hamner | Eighth | 18½ out |
| Tuesday, August 17 |
| » Defeated Cardinals (59-50), 4-2 | Wrigley Field (23-29) | 44-65 | |
| » Starters: Red Munger vs Johnny Schmitz | Eighth | 18½ out |
| Wednesday, August 18 |
| » Lost to Pirates (55-50), 7-4 | Wrigley Field (23-30) | 44-66 | |
| » Starters: Bob Chesnes vs Russ Meyer | Eighth | 18½ out |
| Thursday, August 19 |
| » Lost to Pirates (56-50), 2-1 | Wrigley Field (23-31) | 44-67 | Lost 2 |
| » Starters: Rip Sewell vs Doyle Lade | Eighth | 19 out |
| Friday, August 20 |
| » Defeated Reds (47-66), 5-2 | Wrigley Field (24-31) | 45-67 | |
| » Starters: Howie Fox vs Dutch McCall | Eighth | 18½ out |
| Saturday, August 21 |
| » Lost to Reds (48-66), 2-0 | Wrigley Field (24-32) | 45-68 | |
| » Starters: Johnny Vander Meer vs Hank Borowy | Eighth | 19 out |
| Sunday, August 22 |
| » Defeated Reds (48-67), 10-3 | Wrigley Field (25-32) | 46-68 | |
| » Starters: Ken Raffensberger vs Johnny Schmitz | Eighth | 19 out |
| Tuesday, August 24 |
| » Lost to Giants (59-53), 7-4 | Wrigley Field (25-33) | 46-69 | |
| » Starters: Dave Koslo vs Russ Meyer | Eighth | 20½ out |
| Wednesday, August 25 |
| » Lost to Giants (60-53), 9-4 | Wrigley Field (25-34) | 46-70 | Lost 2 |
| » Starters: Clint Hartung vs Dutch McCall | Eighth | 21½ out |
| Thursday, August 26 |
| » Defeated Braves (68-50), 5-1 | Wrigley Field (26-34) | 47-70 | |
| » Starters: Bill Voiselle vs Doyle Lade | Eighth | 19½ out |
| » Defeated Braves (68-51), 5-2 | Wrigley Field (27-34) | 48-70 | Won 2 |
| » Starters: Vern Bickford vs Hank Borowy | Eighth | 19½ out |
| Friday, August 27 |
| » Defeated Braves (68-52), 1-0 | Wrigley Field (28-34) | 49-70 | Won 3 |
| » Starters: Johnny Sain vs Johnny Schmitz | Eighth | 18½ out |
| Saturday, August 28 |
| » Lost to Braves (69-52), 5-4 | Wrigley Field (28-35) | 49-71 | |
| » Starters: Red Barrett vs Russ Meyer | Eighth | 19½ out |
| Sunday, August 29 |
| » Lost to Phillies (55-66), 1-0 | Wrigley Field (28-36) | 49-72 | Lost 2 |
| » Starters: Monk Dubiel vs Dutch McCall | Eighth | 18½ out |
| » Defeated Phillies (55-67), 10-4 | Wrigley Field (29-36) | 50-72 | |
| » Starters: Curt Simmons vs Ralph Hamner | Eighth | 18½ out |
| Tuesday, August 31 |
| » Defeated Dodgers (68-53), 3-0 | Wrigley Field (30-36) | 51-72 | Won 2 |
| » Starters: Rex Barney vs Hank Borowy | Eighth | 17½ out |
| » Defeated Dodgers (68-54), 7-2 | Wrigley Field (31-36) | 52-72 | Won 3 |
| » Starters: Ralph Branca vs Doyle Lade | Eighth | 17½ out |
| Wednesday, September 1 |
| » Lost to Dodgers (69-54), 6-0 | Wrigley Field (31-37) | 52-73 | |
| » Starters: Preacher Roe vs Johnny Schmitz | Eighth | 18 out |
| Thursday, September 2 |
| » Defeated Dodgers (69-55), 7-6 | Wrigley Field (32-37) | 53-73 | |
| » Starters: Erv Palica vs Dutch McCall | Eighth | 17½ out |
| Friday, September 3 |
| » Defeated Pirates (66-57), 10-1 | Forbes Field (3-6) | 54-73 | Won 2 |
| » Starters: Russ Meyer vs Mel Queen | Sixth | 17½ out |
| Sunday, September 5 |
| » Lost to Pirates (67-57), 7-3 | Forbes Field (3-7) | 54-74 | |
| » Starters: Hank Borowy vs Rip Sewell | Sixth | 18 out |
| » Defeated Pirates (67-58), 11-3 | Forbes Field (4-7) | 55-74 | |
| » Starters: Doyle Lade vs Elmer Riddle | Sixth | 18 out |
| Monday, September 6 |
| » Lost to Reds (55-73), 3-1 | Crosley Field (4-6) | 55-75 | |
| » Starters: Dutch McCall vs Johnny Vander Meer | Sixth | 19 out |
| » Defeated Reds (55-74), 6-2 | Crosley Field (5-6) | 56-75 | |
| » Starters: Bob Rush vs Herm Wehmeier | Sixth | 19 out |
| Wednesday, September 8 |
| » Defeated Cardinals (70-62), 4-2 | Sportsman's Park III (3-4) | 57-75 | Won 2 |
| » Starters: Johnny Schmitz vs Ken Johnson | Sixth | 18½ out |
| Thursday, September 9 |
| » Lost to Cardinals (71-62), 4-0 | Sportsman's Park III (3-5) | 57-76 | |
| » Starters: Hank Borowy vs Harry Brecheen | Sixth | 19 out |
| Saturday, September 11 |
| » Lost to Pirates (73-58), 13-12 | Wrigley Field (32-38) | 57-77 | Lost 2 |
| » Starters: Bob Chesnes vs Doyle Lade | Sixth | 20½ out |
| Sunday, September 12 |
| » Lost to Pirates (74-58), 7-3 | Wrigley Field (32-39) | 57-78 | Lost 3 |
| » Starters: Rip Sewell vs Ralph Hamner | Seventh | 21 out |
| Monday, September 13 |
| » Lost to Dodgers (72-63), 6-4 | Ebbets Field (5-4) | 57-79 | Lost 4 |
| » Starters: Johnny Schmitz vs Rex Barney | Sixth | 21½ out |
| Tuesday, September 14 |
| » Lost to Braves (80-58), 10-3 | Braves Field (2-8) | 57-80 | Lost 5 |
| » Starters: Hank Borowy vs Johnny Sain | Seventh | 22½ out |
| Wednesday, September 15 |
| » Lost to Braves (81-58), 5-2 | Braves Field (2-9) | 57-81 | Lost 6 |
| » Starters: Doyle Lade vs Warren Spahn | Eighth | 23½ out |
| Friday, September 17 |
| » Lost to Phillies (59-81), 6-3 | Shibe Park (4-7) | 57-82 | Lost 7 |
| » Starters: Dutch McCall vs Monk Dubiel | Eighth | 24½ out |
| Sunday, September 19 |
| » Lost to Dodgers (78-65), 8-1 | Ebbets Field (5-5) | 57-83 | Lost 8 |
| » Starters: Johnny Schmitz vs Joe Hatten | Eighth | 26 out |
| Monday, September 20 |
| » Lost to Dodgers (79-65), 4-2 | Ebbets Field (5-6) | 57-84 | Lost 9 |
| » Starters: Hank Borowy vs Preacher Roe | Eighth | 26½ out |
| Tuesday, September 21 |
| » Lost to Giants (75-68), 3-2 | Polo Grounds V (2-6) | 57-85 | Lost 10 |
| » Starters: Doyle Lade vs Larry Jansen | Eighth | 27½ out |
| » Defeated Giants (75-69), 3-2 | Polo Grounds V (3-6) | 58-85 | |
| » Starters: Johnny Schmitz vs Red Webb | Eighth | 27½ out |
| Wednesday, September 22 |
| » Defeated Giants (75-70), 3-2 | Polo Grounds V (4-6) | 59-85 | Won 2 |
| » Starters: Bob Rush vs Dave Koslo | Eighth | 26 out |
| » Defeated Giants (75-71), 11-7 | Polo Grounds V (5-6) | 60-85 | Won 3 |
| » Starters: Dutch McCall vs Andy Hansen | Eighth | 26 out |
| » Major-league debuts: Lou Lombardo (Giants) |
| Friday, September 24 |
| » Lost to Cardinals (80-66), 4-1 | Wrigley Field (32-40) | 60-86 | |
| » Starters: Harry Brecheen vs Cliff Chambers | Eighth | 26½ out |
| » Major-league debuts: Warren Hacker (Cubs) |
| Saturday, September 25 |
| » Defeated Cardinals (80-67), 3-2 | Wrigley Field (33-40) | 61-86 | |
| » Starters: Howie Pollet vs Doyle Lade | Eighth | 25½ out |
| Sunday, September 26 |
| » Lost to Cardinals (81-67), 5-2 | Wrigley Field (33-41) | 61-87 | |
| » Starters: Al Brazle vs Bob Rush | Eighth | 26½ out |
| Tuesday, September 28 |
| » Defeated Reds (62-87), 6-2 | Wrigley Field (34-41) | 62-87 | |
| » Starters: Johnny Vander Meer vs Dutch McCall | Seventh | 25½ out |
| Wednesday, September 29 |
| » Lost to Reds (63-87), 5-3 | Wrigley Field (34-42) | 62-88 | |
| » Starters: Herm Wehmeier vs Warren Hacker | Eighth | 26½ out |
| Thursday, September 30 |
| » Defeated Reds (63-88), 1-0 | Wrigley Field (35-42) | 63-88 | |
| » Starters: Ken Raffensberger vs Cliff Chambers | Sixth | 26 out |
| Friday, October 1 |
| » Lost to Cardinals (84-68), 6-4 | Sportsman's Park III (3-6) | 63-89 | |
| » Starters: Doyle Lade vs Howie Pollet | Seventh | 27 out |
| » Major-league debuts: Carmen Mauro (Cubs) |
| Future Cub Bill Bonham is born in Glendale, CA. |
| Saturday, October 2 |
| » Lost to Cardinals (85-68), 9-0 | Sportsman's Park III (3-7) | 63-90 | Lost 2 |
| » Starters: Hank Borowy vs Al Brazle | Eighth | 27½ out |
| Sunday, October 3 |
| » Defeated Cardinals (85-69), 4-3 | Sportsman's Park III (4-7) | 64-90 | |
| » Starters: Dutch McCall vs Murry Dickson | Eighth | 27½ out |
| » Major-league debuts: Larry Miggins (Cardinals) |
| Tuesday, November 23 |
| Former Cub Hack Wilson dies in Baltimore, MD at the age of 49. |
| Tuesday, December 21 |
| Future Cub |
