| Monday, February 3 |
| Future Senator Joe Coleman is born in Boston, MA. |
| Wednesday, April 2 |
| Former Senator Charlie Jones dies in Two Harbors, MN at the age of 71. |
| Tuesday, April 15 |
| » Lost to Red Sox (1-0), 7-6 | Fenway Park (0-1) | 0-1 | |
| » Starters: Early Wynn vs Tex Hughson | Second | 1 out |
| » Major-league debuts: Harry Dorish and Sam Mele (Red Sox) |
| Thursday, April 17 |
| » Lost to Red Sox (2-0), 4-1 | Fenway Park (0-2) | 0-2 | Lost 2 |
| » Starters: Mickey Haefner vs Joe Dobson | Fifth | 2 out |
| Friday, April 18 |
| » Lost to Yankees (2-1), 7-0 | Griffith Stadium (0-1) | 0-3 | Lost 3 |
| » Starters: Allie Reynolds vs Bobo Newsom | Sixth | 3 out |
| Saturday, April 19 |
| » Defeated Yankees (2-2), 4-2 | Griffith Stadium (1-1) | 1-3 | |
| » Starters: Joe Page vs Sid Hudson | Fifth | 3 out |
| » Major-league debuts: Spec Shea (Yankees) |
| Sunday, April 20 |
| » Defeated Red Sox (4-1), 3-1 | Griffith Stadium (2-1) | 2-3 | Won 2 |
| » Starters: Mel Parnell vs Walt Masterson | Fifth | 1½ out |
| » Major-league debuts: Mel Parnell (Red Sox) |
| Wednesday, April 23 |
| » Defeated Athletics (1-6), 4-3 | Shibe Park (1-0) | 3-3 | Won 3 |
| » Starters: Early Wynn vs Jesse Flores | Fifth | 2 out |
| Friday, April 25 |
| » Major-league debuts: Al Widmar (Red Sox) |
| Saturday, April 26 |
| » Lost to Yankees (7-3), 3-1 | Yankee Stadium (0-1) | 3-4 | |
| » Starters: Mickey Haefner vs Don Johnson | Sixth | 2 out |
| » Major-league debuts: Ralph Houk (Yankees) |
| Sunday, April 27 |
| » Defeated Yankees (7-4), 1-0 | Yankee Stadium (1-1) | 4-4 | |
| » Starters: Sid Hudson vs Spud Chandler | Fourth | 1½ out |
| Wednesday, April 30 |
| » Lost to White Sox (6-4), 5-2 | Comiskey Park I (0-1) | 4-5 | |
| » Starters: Bobo Newsom vs Johnny Rigney | Sixth | 1½ out |
| Thursday, May 1 |
| » Lost to Browns (6-6), 14-5 | Sportsman's Park III (0-1) | 4-6 | Lost 2 |
| » Starters: Walt Masterson vs Jack Kramer | Fifth | 2 out |
| Saturday, May 3 |
| » Defeated Browns (6-7), 5-4 | Sportsman's Park III (1-1) | 5-6 | |
| » Starters: Early Wynn vs Sam Zoldak | Sixth | 2 out |
| Sunday, May 4 |
| » Defeated Indians (7-6), 6-3 | Cleveland Stadium (1-0) | 6-6 | Won 2 |
| » Starters: Sid Hudson vs Don Black | Fifth | 2½ out |
| Saturday, May 10 |
| » Defeated Athletics (7-11), 4-3 | Griffith Stadium (3-1) | 7-6 | Won 3 |
| » Starters: Jesse Flores vs Early Wynn | Third | 2 out |
| Sunday, May 11 |
| » Lost to Athletics (8-11), 4-0 | Griffith Stadium (3-2) | 7-7 | |
| » Starters: Bob Savage vs Sid Hudson | Fourth | 2 out |
| » Defeated Athletics (8-12), 2-1 | Griffith Stadium (4-2) | 8-7 | |
| » Starters: Dick Fowler vs Walt Masterson | Fourth | 2 out |
| Monday, May 12 |
| » Lost to Athletics (9-12), 5-1 | Griffith Stadium (4-3) | 8-8 | |
| » Starters: Phil Marchildon vs Bobo Newsom | Fifth | 2½ out |
| Tuesday, May 13 |
| » Lost to Tigers (13-7), 8-0 | Griffith Stadium (4-4) | 8-9 | Lost 2 |
| » Starters: Hal Newhouser vs Marino Pieretti | Sixth | 3½ out |
| Wednesday, May 14 |
| » Lost to Tigers (14-7), 3-2 | Griffith Stadium (4-5) | 8-10 | Lost 3 |
| » Starters: Fred Hutchinson vs Mickey Haefner | Seventh | 4½ out |
| Thursday, May 15 |
| » Lost to Indians (10-8), 9-1 | Griffith Stadium (4-6) | 8-11 | Lost 4 |
| » Starters: Bryan Stephens vs Early Wynn | Seventh | 5½ out |
| » Major-league debuts: Bryan Stephens (Indians) |
| Friday, May 16 |
| » Defeated Indians (10-9), 2-0 | Griffith Stadium (5-6) | 9-11 | |
| » Starters: Don Black vs Walt Masterson | Seventh | 4½ out |
| Saturday, May 17 |
| » Defeated Indians (10-10), 2-1 | Griffith Stadium (6-6) | 10-11 | Won 2 |
| » Starters: Red Embree vs Bobo Newsom | Fifth | 4½ out |
| Sunday, May 18 |
| » Lost to White Sox (13-14), 4-2 | Griffith Stadium (6-7) | 10-12 | |
| » Starters: Frank Papish vs Mickey Haefner | Seventh | 5½ out |
| » Lost to White Sox (14-14), 3-2 | Griffith Stadium (6-8) | 10-13 | Lost 2 |
| » Starters: Orval Grove vs Marino Pieretti | Seventh | 5½ out |
| Monday, May 19 |
| » Lost to White Sox (15-14), 4-1 | Griffith Stadium (6-9) | 10-14 | Lost 3 |
| » Starters: Bob Gillespie vs Early Wynn | Seventh | 6 out |
| Tuesday, May 20 |
| » Lost to White Sox (16-14), 7-4 | Griffith Stadium (6-10) | 10-15 | Lost 4 |
| » Starters: Eddie Smith vs Walt Masterson | Seventh | 6 out |
| Wednesday, May 21 |
| » Defeated Browns (10-19), 7-3 | Griffith Stadium (7-10) | 11-15 | |
| » Starters: Sam Zoldak vs Bobo Newsom | Seventh | 5 out |
| Friday, May 23 |
| » Lost to Athletics (15-15), 8-1 | Shibe Park (1-1) | 11-16 | |
| » Starters: Mickey Haefner vs Phil Marchildon | Seventh | 6 out |
| Saturday, May 24 |
| » Defeated Athletics (15-16), 5-0 | Shibe Park (2-1) | 12-16 | |
| » Starters: Marino Pieretti vs Dick Fowler | Seventh | 6 out |
| Sunday, May 25 |
| » Defeated Athletics (15-17), 3-1 | Shibe Park (3-1) | 13-16 | Won 2 |
| » Starters: Early Wynn vs Joe Coleman | Seventh | 5½ out |
| Tuesday, May 27 |
| » Defeated Yankees (17-15), 5-4 | Griffith Stadium (8-10) | 14-16 | Won 3 |
| » Starters: Allie Reynolds vs Walt Masterson | Sixth | 6 out |
| Wednesday, May 28 |
| » Lost to Yankees (18-15), 9-5 | Griffith Stadium (8-11) | 14-17 | |
| » Starters: Tommy Byrne vs Bobo Newsom | Sixth | 6½ out |
| Thursday, May 29 |
| » Lost to Yankees (19-15), 5-2 | Griffith Stadium (8-12) | 14-18 | Lost 2 |
| » Starters: Spec Shea vs Early Wynn | Seventh | 6½ out |
| Friday, May 30 |
| » Defeated Red Sox (19-18), 13-6 | Griffith Stadium (9-12) | 15-18 | |
| » Starters: Tex Hughson vs Marino Pieretti | Sixth | 5½ out |
| » Defeated Red Sox (19-19), 5-3 | Griffith Stadium (10-12) | 16-18 | Won 2 |
| » Starters: Joe Dobson vs Mickey Haefner | Sixth | 5½ out |
| Saturday, May 31 |
| » Lost to Tigers (24-14), 5-4 | Tiger Stadium (0-1) | 16-19 | |
| » Starters: Walt Masterson vs Stubby Overmire | Sixth | 6½ out |
| Tuesday, June 3 |
| » Defeated Indians (16-16), 6-5 | Cleveland Stadium (2-0) | 17-19 | |
| » Starters: Bobo Newsom vs Red Embree | Sixth | 5½ out |
| Wednesday, June 4 |
| » Lost to Indians (17-16), 6-2 | Cleveland Stadium (2-1) | 17-20 | |
| » Starters: Ray Scarborough vs Bob Feller | Sixth | 6 out |
| Thursday, June 5 |
| » Defeated Indians (17-17), 3-0 | Cleveland Stadium (3-1) | 18-20 | |
| » Starters: Early Wynn vs Don Black | Fifth | 5 out |
| Friday, June 6 |
| » Lost to White Sox (21-25), 5-4 | Comiskey Park I (0-2) | 18-21 | |
| » Starters: Sid Hudson vs Ed Lopat | Sixth | 5½ out |
| Saturday, June 7 |
| » Lost to White Sox (22-25), 4-0 | Comiskey Park I (0-3) | 18-22 | Lost 2 |
| » Starters: Mickey Haefner vs Johnny Rigney | Seventh | 6 out |
| Sunday, June 8 |
| » Defeated White Sox (22-26), 1-0 | Comiskey Park I (1-3) | 19-22 | |
| » Starters: Walt Masterson vs Frank Papish | Seventh | 6½ out |
| » Lost to White Sox (23-26), 8-2 | Comiskey Park I (1-4) | 19-23 | |
| » Starters: Marino Pieretti vs Bob Gillespie | Seventh | 6½ out |
| Monday, June 9 |
| » Lost to Browns (19-25), 1-0 | Sportsman's Park III (1-2) | 19-24 | Lost 2 |
| » Starters: Bobo Newsom vs Ellis Kinder | Seventh | 6½ out |
| Tuesday, June 10 |
| » Lost to Browns (20-25), 2-1 | Sportsman's Park III (1-3) | 19-25 | Lost 3 |
| » Starters: Sid Hudson vs Bob Muncrief | Eighth | 6½ out |
| Wednesday, June 11 |
| » Defeated Browns (20-26), 4-2 | Sportsman's Park III (2-3) | 20-25 | |
| » Starters: Early Wynn vs Sam Zoldak | Seventh | 6 out |
| Sunday, June 15 |
| » Defeated Tigers (27-21), 1-0 | Griffith Stadium (11-12) | 21-25 | Won 2 |
| » Starters: Hal Newhouser vs Walt Masterson | Fifth | 5 out |
| » Defeated Tigers (27-22), 5-1 | Griffith Stadium (12-12) | 22-25 | Won 3 |
| » Starters: Stubby Overmire vs Mickey Haefner | Fifth | 5 out |
| Tuesday, June 17 |
| » Lost to Indians (22-22), 5-3 | Griffith Stadium (12-13) | 22-26 | |
| » Starters: Bob Feller vs Bobo Newsom | Sixth | 6 out |
| Wednesday, June 18 |
| » Lost to Indians (23-22), 9-3 | Griffith Stadium (12-14) | 22-27 | Lost 2 |
| » Starters: Don Black vs Sid Hudson | Sixth | 6½ out |
| Thursday, June 19 |
| » Defeated Indians (23-23), 3-2 | Griffith Stadium (13-14) | 23-27 | |
| » Starters: Bryan Stephens vs Early Wynn | Sixth | 5½ out |
| Friday, June 20 |
| » Defeated Browns (21-32), 3-0 | Griffith Stadium (14-14) | 24-27 | Won 2 |
| » Starters: Fred Sanford vs Walt Masterson | Sixth | 5½ out |
| Saturday, June 21 |
| » Defeated Browns (21-33), 5-4 | Griffith Stadium (15-14) | 25-27 | Won 3 |
| » Starters: Nels Potter vs Mickey Haefner | Sixth | 6 out |
| Sunday, June 22 |
| » Defeated Browns (21-34), 3-2 | Griffith Stadium (16-14) | 26-27 | Won 4 |
| » Starters: Jack Kramer vs Bobo Newsom | Sixth | 6½ out |
| » Lost to Browns (22-34), 9-6 | Griffith Stadium (16-15) | 26-28 | |
| » Starters: Sam Zoldak vs Sid Hudson | Sixth | 6½ out |
| Monday, June 23 |
| » Lost to White Sox (29-32), 10-6 | Griffith Stadium (16-16) | 26-29 | Lost 2 |
| » Starters: Thornton Lee vs Early Wynn | Seventh | 7½ out |
| Tuesday, June 24 |
| » Lost to White Sox (30-32), 3-0 | Griffith Stadium (16-17) | 26-30 | Lost 3 |
| » Starters: Ed Lopat vs Walt Masterson | Seventh | 8 out |
| Thursday, June 26 |
| » Defeated Red Sox (33-26), 7-3 | Griffith Stadium (17-17) | 27-30 | |
| » Starters: Joe Dobson vs Bobo Newsom | Seventh | 7½ out |
| Friday, June 27 |
| » Defeated Red Sox (33-27), 3-0 | Griffith Stadium (18-17) | 28-30 | Won 2 |
| » Starters: Harry Dorish vs Mickey Haefner | Sixth | 7½ out |
| Saturday, June 28 |
| » Lost to Red Sox (34-27), 8-0 | Griffith Stadium (18-18) | 28-31 | |
| » Starters: Denny Galehouse vs Sid Hudson | Sixth | 8½ out |
| Sunday, June 29 |
| » Defeated Yankees (39-26), 5-1 | Griffith Stadium (19-18) | 29-31 | |
| » Starters: Karl Drews vs Early Wynn | Sixth | 8½ out |
| » Lost to Yankees (40-26), 3-1 | Griffith Stadium (19-19) | 29-32 | |
| » Starters: Don Johnson vs Walt Masterson | Sixth | 8½ out |
| Monday, June 30 |
| » Defeated Athletics (33-32), 8-7 | Griffith Stadium (20-19) | 30-32 | |
| » Starters: Dick Fowler vs Bobo Newsom | Sixth | 8½ out |
| Wednesday, July 2 |
| » Lost to Yankees (42-26), 8-1 | Yankee Stadium (1-2) | 30-33 | |
| » Starters: Mickey Haefner vs Allie Reynolds | Fifth | 9½ out |
| Friday, July 4 |
| » Lost to Yankees (43-26), 7-3 | Yankee Stadium (1-3) | 30-34 | Lost 2 |
| » Starters: Early Wynn vs Spud Chandler | Seventh | 11½ out |
| » Lost to Yankees (44-26), 4-2 | Yankee Stadium (1-4) | 30-35 | Lost 3 |
| » Starters: Walt Masterson vs Don Johnson | Seventh | 11½ out |
| Saturday, July 5 |
| » Lost to Red Sox (36-33), 7-6 | Fenway Park (0-3) | 30-36 | Lost 4 |
| » Starters: Sid Hudson vs Joe Dobson | Seventh | 12½ out |
| Sunday, July 6 |
| » Lost to Red Sox (37-33), 7-4 | Fenway Park (0-4) | 30-37 | Lost 5 |
| » Starters: Bobo Newsom vs Mickey Harris | Seventh | 14½ out |
| » Lost to Red Sox (38-33), 10-1 | Fenway Park (0-5) | 30-38 | Lost 6 |
| » Starters: Mickey Haefner vs Denny Galehouse | Seventh | 14½ out |
| Thursday, July 10 |
| » Defeated White Sox (35-40), 4-0 | Comiskey Park I (2-4) | 31-38 | |
| » Starters: Early Wynn vs Eddie Smith | Seventh | 14 out |
| » Defeated White Sox (35-41), 7-2 | Comiskey Park I (3-4) | 32-38 | Won 2 |
| » Starters: Ray Scarborough vs Frank Papish | Seventh | 14 out |
| Friday, July 11 |
| » Defeated White Sox (35-42), 4-3 | Comiskey Park I (4-4) | 33-38 | Won 3 |
| » Starters: Walt Masterson vs Bob Gillespie | Sixth | 14 out |
| Saturday, July 12 |
| » Lost to White Sox (36-42), 6-5 | Comiskey Park I (4-5) | 33-39 | |
| » Starters: Marino Pieretti vs Ed Lopat | Seventh | 15½ out |
| Sunday, July 13 |
| » Defeated Browns (25-48), 4-2 | Sportsman's Park III (3-3) | 34-39 | |
| » Starters: Sid Hudson vs Fred Sanford | Sixth | 16½ out |
| » Lost to Browns (26-48), 3-2 | Sportsman's Park III (3-4) | 34-40 | |
| » Starters: Mickey Haefner vs Cliff Fannin | Sixth | 16½ out |
| Monday, July 14 |
| » Lost to Browns (27-48), 13-3 | Sportsman's Park III (3-5) | 34-41 | Lost 2 |
| » Starters: Early Wynn vs Sam Zoldak | Sixth | 17 out |
| Tuesday, July 15 |
| » Lost to Tigers (41-34), 11-6 | Tiger Stadium (0-2) | 34-42 | Lost 3 |
| » Starters: Ray Scarborough vs Dizzy Trout | Seventh | 18½ out |
| Wednesday, July 16 |
| » Lost to Tigers (42-34), 9-8 | Tiger Stadium (0-3) | 34-43 | Lost 4 |
| » Starters: Walt Masterson vs Hal Newhouser | Seventh | 19 out |
| » Defeated Tigers (42-35), 10-1 | Tiger Stadium (1-3) | 35-43 | |
| » Starters: Marino Pieretti vs Stubby Overmire | Seventh | 19 out |
| Thursday, July 17 |
| » Lost to Tigers (43-35), 7-5 | Tiger Stadium (1-4) | 35-44 | |
| » Starters: Mickey Haefner vs Al Benton | Seventh | 21 out |
| » Lost to Tigers (44-35), 4-3 | Tiger Stadium (1-5) | 35-45 | Lost 2 |
| » Starters: Sid Hudson vs Virgil Trucks | Seventh | 21 out |
| Friday, July 18 |
| » Lost to Indians (37-40), 6-0 | Cleveland Stadium (3-2) | 35-46 | Lost 3 |
| » Starters: Early Wynn vs Don Black | Seventh | 21 out |
| Sunday, July 20 |
| » Defeated Indians (37-41), 1-0 | Cleveland Stadium (4-2) | 36-46 | |
| » Starters: Mickey Haefner vs Bob Feller | Seventh | 20½ out |
| » Lost to Indians (38-41), 6-1 | Cleveland Stadium (4-3) | 36-47 | |
| » Starters: Walt Masterson vs Mel Harder | Seventh | 20½ out |
| Tuesday, July 22 |
| » Defeated Tigers (47-37), 6-1 | Griffith Stadium (21-19) | 37-47 | |
| » Starters: Al Benton vs Early Wynn | Seventh | 20½ out |
| Wednesday, July 23 |
| » Defeated Tigers (47-38), 5-0 | Griffith Stadium (22-19) | 38-47 | Won 2 |
| » Starters: Fred Hutchinson vs Ray Scarborough | Sixth | 19½ out |
| Thursday, July 24 |
| » Defeated Tigers (47-39), 3-0 | Griffith Stadium (23-19) | 39-47 | Won 3 |
| » Starters: Hal Newhouser vs Walt Masterson | Sixth | 19½ out |
| Friday, July 25 |
| » Defeated Indians (39-44), 5-1 | Griffith Stadium (24-19) | 40-47 | Won 4 |
| » Starters: Steve Gromek vs Mickey Haefner | Sixth | 19½ out |
| Saturday, July 26 |
| » Defeated Indians (39-45), 8-4 | Griffith Stadium (25-19) | 41-47 | Won 5 |
| » Starters: Mel Harder vs Marino Pieretti | Fifth | 18½ out |
| Sunday, July 27 |
| » Lost to Indians (40-45), 2-1 | Griffith Stadium (25-20) | 41-48 | |
| » Starters: Al Gettel vs Early Wynn | Sixth | 19 out |
| Tuesday, July 29 |
| » Lost to Browns (33-58), 8-2 | Griffith Stadium (25-21) | 41-49 | Lost 2 |
| » Starters: Sam Zoldak vs Ray Scarborough | Sixth | 20 out |
| Wednesday, July 30 |
| » Lost to Browns (34-58), 2-1 | Griffith Stadium (25-22) | 41-50 | Lost 3 |
| » Starters: Ellis Kinder vs Walt Masterson | Sixth | 21 out |
| Thursday, July 31 |
| » Defeated Browns (34-59), 4-1 | Griffith Stadium (26-22) | 42-50 | |
| » Starters: Fred Sanford vs Mickey Haefner | Sixth | 20½ out |
| Friday, August 1 |
| » Defeated White Sox (42-57), 8-1 | Griffith Stadium (27-22) | 43-50 | Won 2 |
| » Starters: Joe Haynes vs Early Wynn | Sixth | 19½ out |
| Saturday, August 2 |
| » Lost to White Sox (43-57), 13-1 | Griffith Stadium (27-23) | 43-51 | |
| » Starters: Orval Grove vs Sid Hudson | Sixth | 21 out |
| Sunday, August 3 |
| » Lost to White Sox (44-57), 2-1 | Griffith Stadium (27-24) | 43-52 | Lost 2 |
| » Starters: Frank Papish vs Ray Scarborough | Sixth | 22 out |
| Tuesday, August 5 |
| » Defeated Red Sox (53-46), 3-1 | Griffith Stadium (28-24) | 44-52 | |
| » Starters: Dave Ferriss vs Walt Masterson | Sixth | 21½ out |
| Wednesday, August 6 |
| » Defeated Red Sox (53-47), 1-0 | Griffith Stadium (29-24) | 45-52 | Won 2 |
| » Starters: Earl Johnson vs Mickey Haefner | Sixth | 20½ out |
| Thursday, August 7 |
| » Lost to Red Sox (54-47), 12-2 | Griffith Stadium (29-25) | 45-53 | |
| » Starters: Denny Galehouse vs Early Wynn | Sixth | 21 out |
| Saturday, August 9 |
| » Lost to Athletics (54-51), 8-1 | Shibe Park (3-2) | 45-54 | Lost 2 |
| » Starters: Sid Hudson vs Phil Marchildon | Sixth | 20½ out |
| Sunday, August 10 |
| » Lost to Athletics (55-51), 3-2 | Shibe Park (3-3) | 45-55 | Lost 3 |
| » Starters: Walt Masterson vs Joe Coleman | Seventh | 21 out |
| » Defeated Athletics (55-52), 5-2 | Shibe Park (4-3) | 46-55 | |
| » Starters: Ray Scarborough vs Jesse Flores | Seventh | 21 out |
| Monday, August 11 |
| » Lost to Red Sox (57-48), 1-0 | Fenway Park (0-6) | 46-56 | |
| » Starters: Mickey Haefner vs Earl Johnson | Seventh | 21 out |
| Tuesday, August 12 |
| » Lost to Red Sox (58-48), 2-1 | Fenway Park (0-7) | 46-57 | Lost 2 |
| » Starters: Early Wynn vs Denny Galehouse | Seventh | 21½ out |
| Wednesday, August 13 |
| » Lost to Red Sox (59-48), 10-3 | Fenway Park (0-8) | 46-58 | Lost 3 |
| » Starters: Milo Candini vs Tex Hughson | Seventh | 22½ out |
| Friday, August 15 |
| » Lost to Athletics (57-54), 3-0 | Griffith Stadium (29-26) | 46-59 | Lost 4 |
| » Starters: Joe Coleman vs Walt Masterson | Seventh | 24 out |
| Saturday, August 16 |
| » Lost to Athletics (58-54), 5-2 | Griffith Stadium (29-27) | 46-60 | Lost 5 |
| » Starters: Bill McCahan vs Ray Scarborough | Seventh | 25 out |
| Sunday, August 17 |
| » Lost to Athletics (59-54), 2-1 | Griffith Stadium (29-28) | 46-61 | Lost 6 |
| » Starters: Dick Fowler vs Early Wynn | Seventh | 25½ out |
| » Lost to Athletics (60-54), 5-2 | Griffith Stadium (29-29) | 46-62 | Lost 7 |
| » Starters: Phil Marchildon vs Mickey Haefner | Seventh | 25½ out |
| Tuesday, August 19 |
| » Lost to Indians (55-54), 13-2 | Cleveland Stadium (4-4) | 46-63 | Lost 8 |
| » Starters: Walt Masterson vs Mel Harder | Seventh | 26 out |
| » Lost to Indians (56-54), 9-1 | Cleveland Stadium (4-5) | 46-64 | Lost 9 |
| » Starters: Ray Scarborough vs Red Embree | Seventh | 26 out |
| Wednesday, August 20 |
| » Lost to Indians (57-54), 4-3 | Cleveland Stadium (4-6) | 46-65 | Lost 10 |
| » Starters: Marino Pieretti vs Steve Gromek | Seventh | 27½ out |
| » Lost to Indians (58-54), 7-6 | Cleveland Stadium (4-7) | 46-66 | Lost 11 |
| » Starters: Mickey Haefner vs Bob Lemon | Seventh | 27½ out |
| Thursday, August 21 |
| » Defeated Tigers (60-53), 3-2 | Tiger Stadium (2-5) | 47-66 | |
| » Starters: Early Wynn vs Hal Newhouser | Seventh | 27 out |
| » Defeated Tigers (60-54), 5-3 | Tiger Stadium (3-5) | 48-66 | Won 2 |
| » Starters: Sid Hudson vs Fred Hutchinson | Seventh | 27 out |
| Friday, August 22 |
| » Lost to Tigers (61-54), 7-6 | Tiger Stadium (3-6) | 48-67 | |
| » Starters: Walt Masterson vs Dizzy Trout | Seventh | 27 out |
| » Lost to Tigers (62-54), 2-0 | Tiger Stadium (3-7) | 48-68 | Lost 2 |
| » Starters: Ray Scarborough vs Art Houtteman | Seventh | 27 out |
| Saturday, August 23 |
| » Defeated Tigers (62-55), 5-3 | Tiger Stadium (4-7) | 49-68 | |
| » Starters: Marino Pieretti vs Stubby Overmire | Seventh | 27 out |
| Sunday, August 24 |
| » Lost to Browns (43-77), 7-1 | Sportsman's Park III (3-6) | 49-69 | |
| » Starters: Mickey Haefner vs Cliff Fannin | Seventh | 27 out |
| » Defeated Browns (43-78), 7-4 | Sportsman's Park III (4-6) | 50-69 | |
| » Starters: Scott Cary vs Fred Sanford | Seventh | 27 out |
| Monday, August 25 |
| » Lost to Browns (44-78), 1-0 | Sportsman's Park III (4-7) | 50-70 | |
| » Starters: Ray Scarborough vs Sam Zoldak | Seventh | 27 out |
| Tuesday, August 26 |
| » Defeated White Sox (57-66), 4-3 | Comiskey Park I (5-5) | 51-70 | |
| » Starters: Walt Masterson vs Ed Lopat | Seventh | 26 out |
| Wednesday, August 27 |
| » Defeated White Sox (57-67), 6-5 | Comiskey Park I (6-5) | 52-70 | Won 2 |
| » Starters: Sid Hudson vs Thornton Lee | Seventh | 26 out |
| Friday, August 29 |
| » Lost to Yankees (80-45), 4-3 | Yankee Stadium (1-5) | 52-71 | |
| » Starters: Early Wynn vs Bobo Newsom | Seventh | 27 out |
| Saturday, August 30 |
| » Lost to Yankees (81-45), 6-5 | Yankee Stadium (1-6) | 52-72 | Lost 2 |
| » Starters: Ray Scarborough vs Spec Shea | Seventh | 28 out |
| Sunday, August 31 |
| » Lost to Yankees (82-45), 6-5 | Yankee Stadium (1-7) | 52-73 | Lost 3 |
| » Starters: Walt Masterson vs Vic Raschi | Seventh | 30 out |
| » Lost to Yankees (83-45), 5-1 | Yankee Stadium (1-8) | 52-74 | Lost 4 |
| » Starters: Sid Hudson vs Butch Wensloff | Seventh | 30 out |
| Monday, September 1 |
| » Defeated Athletics (65-63), 4-0 | Shibe Park (5-3) | 53-74 | |
| » Starters: Mickey Haefner vs Phil Marchildon | Seventh | 28 out |
| » Defeated Athletics (65-64), 7-4 | Shibe Park (6-3) | 54-74 | Won 2 |
| » Starters: Scott Cary vs Dick Fowler | Seventh | 28 out |
| Tuesday, September 2 |
| » Defeated Athletics (65-65), 7-4 | Shibe Park (7-3) | 55-74 | Won 3 |
| » Starters: Early Wynn vs Joe Coleman | Seventh | 27½ out |
| Wednesday, September 3 |
| » Lost to Athletics (66-65), 3-0 | Shibe Park (7-4) | 55-75 | |
| » Starters: Ray Scarborough vs Bill McCahan | Seventh | 29 out |
| Thursday, September 4 |
| » Defeated Yankees (85-48), 5-4 | Griffith Stadium (30-29) | 56-75 | |
| » Starters: Vic Raschi vs Walt Masterson | Seventh | 28 out |
| Friday, September 5 |
| » Defeated Yankees (85-49), 3-2 | Griffith Stadium (31-29) | 57-75 | Won 2 |
| » Starters: Butch Wensloff vs Mickey Haefner | Seventh | 27 out |
| » Major-league debuts: Dick Starr (Yankees) |
| Saturday, September 6 |
| » Defeated Yankees (85-50), 9-6 | Griffith Stadium (32-29) | 58-75 | Won 3 |
| » Starters: Karl Drews vs Early Wynn | Seventh | 26 out |
| Sunday, September 7 |
| » Lost to Yankees (86-50), 7-1 | Griffith Stadium (32-30) | 58-76 | |
| » Starters: Allie Reynolds vs Ray Scarborough | Seventh | 27 out |
| Tuesday, September 9 |
| » Lost to White Sox (63-73), 6-1 | Griffith Stadium (32-31) | 58-77 | Lost 2 |
| » Starters: Ed Lopat vs Scott Cary | Seventh | 27 out |
| Wednesday, September 10 |
| » Defeated White Sox (63-74), 3-1 | Griffith Stadium (33-31) | 59-77 | |
| » Starters: Orval Grove vs Walt Masterson | Seventh | 27 out |
| Thursday, September 11 |
| » Lost to Browns (51-86), 2-0 | Griffith Stadium (33-32) | 59-78 | |
| » Starters: Sam Zoldak vs Mickey Haefner | Seventh | 27½ out |
| Friday, September 12 |
| » Lost to Browns (52-86), 9-3 | Griffith Stadium (33-33) | 59-79 | Lost 2 |
| » Starters: Jack Kramer vs Early Wynn | Seventh | 27½ out |
| » Major-league debuts: Buzz Dozier (Senators) |
| Saturday, September 13 |
| » Lost to Browns (53-86), 1-0 | Griffith Stadium (33-34) | 59-80 | Lost 3 |
| » Starters: Cliff Fannin vs Ray Scarborough | Seventh | 28½ out |
| Sunday, September 14 |
| » Lost to Tigers (76-65), 16-6 | Griffith Stadium (33-35) | 59-81 | Lost 4 |
| » Starters: Fred Hutchinson vs Walt Masterson | Seventh | 30 out |
| » Lost to Tigers (77-65), 8-4 | Griffith Stadium (33-36) | 59-82 | Lost 5 |
| » Starters: Dizzy Trout vs Milo Candini | Seventh | 30 out |
| Monday, September 15 |
| » Lost to Tigers (78-65), 7-2 | Griffith Stadium (33-37) | 59-83 | Lost 6 |
| » Starters: Stubby Overmire vs Mickey Haefner | Seventh | 30½ out |
| Tuesday, September 16 |
| » Defeated Tigers (78-66), 4-1 | Griffith Stadium (34-37) | 60-83 | |
| » Starters: Hal Newhouser vs Early Wynn | Seventh | 30 out |
| Wednesday, September 17 |
| » Lost to Indians (76-68), 7-0 | Griffith Stadium (34-38) | 60-84 | |
| » Starters: Al Gettel vs Ray Scarborough | Seventh | 31 out |
| » Major-league debuts: Hal Toenes (Senators) |
| Thursday, September 18 |
| » Lost to Indians (77-68), 4-0 | Griffith Stadium (34-39) | 60-85 | Lost 2 |
| » Starters: Bob Kuzava vs Walt Masterson | Seventh | 32 out |
| Saturday, September 20 |
| » Defeated Red Sox (79-68), 6-3 | Fenway Park (1-8) | 61-85 | |
| » Starters: Early Wynn vs Earl Johnson | Seventh | 31½ out |
| » Lost to Red Sox (80-68), 7-2 | Fenway Park (1-9) | 61-86 | |
| » Starters: Hal Toenes vs Denny Galehouse | Seventh | 31½ out |
| Sunday, September 21 |
| » Defeated Red Sox (80-69), 3-0 | Fenway Park (2-9) | 62-86 | |
| » Starters: Ray Scarborough vs Joe Dobson | Seventh | 31½ out |
| Tuesday, September 23 |
| » Lost to Yankees (95-55), 2-0 | Yankee Stadium (1-9) | 62-87 | |
| » Starters: Walt Masterson vs Allie Reynolds | Seventh | 33½ out |
| » Lost to Yankees (96-55), 3-1 | Yankee Stadium (1-10) | 62-88 | Lost 2 |
| » Starters: Mickey Haefner vs Spec Shea | Seventh | 33½ out |
| Friday, September 26 |
| » Lost to Athletics (77-74), 11-8 | Griffith Stadium (34-40) | 62-89 | Lost 3 |
| » Starters: Dick Fowler vs Early Wynn | Seventh | 33 out |
| » Defeated Athletics (77-75), 4-3 | Griffith Stadium (35-40) | 63-89 | |
| » Starters: Bill McCahan vs Ray Scarborough | Seventh | 33 out |
| » Major-league debuts: Cal Ermer (Senators) |
| Saturday, September 27 |
| » Lost to Red Sox (83-70), 8-1 | Griffith Stadium (35-41) | 63-90 | |
| » Starters: Joe Dobson vs Walt Masterson | Seventh | 33 out |
| Sunday, September 28 |
| » Defeated Red Sox (83-71), 5-1 | Griffith Stadium (36-41) | 64-90 | |
| » Starters: Earl Johnson vs Mickey Haefner | Seventh | 33 out |
| Sunday, October 26 |
| Future Senator Bill Gogolewski is born in Oshkosh, WI. |
Game information provided by Retrosheet (www.retrosheet.org) |
