| Friday, March 15 |
| Future Indian Bobby Bonds is born in Riverside, CA. |
| Thursday, March 21 |
| Future Indian Al Fitzmorris is born in Buffalo, NY. |
| Wednesday, March 27 |
| Future Indian Mike Jackson is born in Paterson, NJ. Future Indian Bill Sudakis is born in Joliet, IL. |
| Wednesday, April 10 |
| Future Indian Phil Hennigan is born in Jasper, TX. |
| Tuesday, April 16 |
| » Defeated White Sox (0-1), 1-0 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Bob Feller vs Bill Dietrich | First | -- |
| Wednesday, April 17 |
| » Defeated White Sox (0-2), 7-1 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Allie Reynolds vs Johnny Rigney | First | -- |
| Saturday, April 20 |
| » Lost to Tigers (3-1), 7-0 | Cleveland Stadium (0-1) | 2-1 | |
| » Starters: Hal Newhouser vs Steve Gromek | Third | 1½ out |
| » Major-league debuts: Sherm Lollar (Indians) |
| Sunday, April 21 |
| » Lost to Tigers (4-1), 3-2 | Cleveland Stadium (0-2) | 2-2 | Lost 2 |
| » Starters: Stubby Overmire vs Bob Feller | Fourth | 2 out |
| Wednesday, April 24 |
| » Defeated Browns (3-4), 5-1 | Sportsman's Park III (1-0) | 3-2 | |
| » Starters: Red Embree vs Denny Galehouse | Fourth | 2 out |
| Former Indian Joe Birmingham dies in Tampico, Mexico at the age of 62. |
| Thursday, April 25 |
| » Lost to White Sox (3-5), 11-2 | League Park II (0-1) | 3-3 | |
| » Starters: Ed Lopat vs Allie Reynolds | Third | 2 out |
| Friday, April 26 |
| » Lost to White Sox (4-5), 4-2 | League Park II (0-2) | 3-4 | Lost 2 |
| » Starters: Joe Haynes vs Bob Feller | Fourth | 3 out |
| Saturday, April 27 |
| » Lost to Tigers (7-3), 5-4 | Tiger Stadium (0-1) | 3-5 | Lost 3 |
| » Starters: Steve Gromek vs Dizzy Trout | Sixth | 4 out |
| Sunday, April 28 |
| » Defeated Tigers (7-4), 3-1 | Tiger Stadium (1-1) | 4-5 | |
| » Starters: Red Embree vs Stubby Overmire | Fifth | 4 out |
| Tuesday, April 30 |
| » Defeated Yankees (9-5), 1-0 | Yankee Stadium (1-0) | 5-5 | Won 2 |
| » Starters: Bob Feller vs Bill Bevens | Fourth | 4 out |
| Wednesday, May 1 |
| » Lost to Yankees (10-5), 6-3 | Yankee Stadium (1-1) | 5-6 | |
| » Starters: Allie Reynolds vs Red Ruffing | Fourth | 5 out |
| Thursday, May 2 |
| » Lost to Yankees (11-5), 8-2 | Yankee Stadium (1-2) | 5-7 | Lost 2 |
| » Starters: Vic Johnson vs Spud Chandler | Fifth | 6 out |
| Friday, May 3 |
| » Lost to Red Sox (14-3), 9-4 | Fenway Park (0-1) | 5-8 | Lost 3 |
| » Starters: Red Embree vs Mickey Harris | Sixth | 7 out |
| Saturday, May 4 |
| » Lost to Red Sox (15-3), 6-2 | Fenway Park (0-2) | 5-9 | Lost 4 |
| » Starters: Bob Feller vs Jim Bagby | Sixth | 8 out |
| Sunday, May 5 |
| » Lost to Senators (6-9), 12-4 | Griffith Stadium (0-1) | 5-10 | Lost 5 |
| » Starters: Allie Reynolds vs Dutch Leonard | Sixth | 8½ out |
| Monday, May 6 |
| » Lost to Senators (7-9), 7-4 | Griffith Stadium (0-2) | 5-11 | Lost 6 |
| » Starters: Steve Gromek vs Ray Scarborough | Sixth | 10 out |
| Tuesday, May 7 |
| » Lost to Senators (8-9), 2-1 | Griffith Stadium (0-3) | 5-12 | Lost 7 |
| » Starters: Red Embree vs Mickey Haefner | Seventh | 11 out |
| Wednesday, May 8 |
| » Defeated Athletics (5-16), 5-2 | Shibe Park (1-0) | 6-12 | |
| » Starters: Bob Feller vs Lou Knerr | Seventh | 11 out |
| Thursday, May 9 |
| » Lost to Athletics (6-16), 7-6 | Shibe Park (1-1) | 6-13 | |
| » Starters: Don Black vs Bobo Newsom | Seventh | 12 out |
| Sunday, May 12 |
| » Defeated Browns (9-13), 4-3 | Cleveland Stadium (1-2) | 7-13 | |
| » Starters: Jack Kramer vs Bob Feller | Seventh | 12½ out |
| » Lost to Browns (10-13), 9-3 | Cleveland Stadium (1-3) | 7-14 | |
| » Starters: Tex Shirley vs Allie Reynolds | Seventh | 12½ out |
| Monday, May 13 |
| » Defeated Browns (10-14), 9-2 | League Park II (1-2) | 8-14 | |
| » Starters: Stan Ferens vs Red Embree | Sixth | 12½ out |
| » Lost to Browns (11-14), 3-0 | League Park II (1-3) | 8-15 | |
| » Starters: Al Milnar vs Joe Krakauskas | Sixth | 12½ out |
| Wednesday, May 15 |
| » Defeated Athletics (7-19), 3-0 | League Park II (2-3) | 9-15 | |
| » Starters: Jack Knott vs Mel Harder | Sixth | 11½ out |
| » Defeated Athletics (7-20), 5-0 | League Park II (3-3) | 10-15 | Won 2 |
| » Starters: Bobo Newsom vs Steve Gromek | Sixth | 11½ out |
| Friday, May 17 |
| » Defeated Senators (12-13), 3-0 | League Park II (4-3) | 11-15 | Won 3 |
| » Starters: Mickey Haefner vs Bob Feller | Sixth | 11 out |
| » Lost to Senators (13-13), 9-4 | League Park II (4-4) | 11-16 | |
| » Starters: Walt Masterson vs Joe Krakauskas | Sixth | 11 out |
| Sunday, May 19 |
| » Lost to Yankees (19-11), 2-0 | Cleveland Stadium (1-4) | 11-17 | Lost 2 |
| » Starters: Spud Chandler vs Allie Reynolds | Sixth | 12½ out |
| » Lost to Yankees (20-11), 7-1 | Cleveland Stadium (1-5) | 11-18 | Lost 3 |
| » Starters: Red Ruffing vs Red Embree | Sixth | 12½ out |
| Monday, May 20 |
| » Defeated Yankees (20-12), 4-3 | League Park II (5-4) | 12-18 | |
| » Starters: Marius Russo vs Steve Gromek | Sixth | 12 out |
| Tuesday, May 21 |
| » Defeated Yankees (20-13), 7-2 | League Park II (6-4) | 13-18 | Won 2 |
| » Starters: Bill Bevens vs Bob Feller | Sixth | 12 out |
| Wednesday, May 22 |
| » Lost to Red Sox (27-7), 7-4 | League Park II (6-5) | 13-19 | |
| » Starters: Mickey Harris vs Mel Harder | Sixth | 13 out |
| Thursday, May 23 |
| » Defeated Red Sox (27-8), 3-2 | League Park II (7-5) | 14-19 | |
| » Starters: Bob Klinger vs Red Embree | Sixth | 12 out |
| Saturday, May 25 |
| » Defeated Browns (15-19), 1-0 | Sportsman's Park III (2-0) | 15-19 | Won 2 |
| » Starters: Allie Reynolds vs Sam Zoldak | Fifth | 12 out |
| Sunday, May 26 |
| » Lost to Browns (16-19), 8-2 | Sportsman's Park III (2-1) | 15-20 | |
| » Starters: Bob Feller vs Nels Potter | Fifth | 12 out |
| » Defeated Browns (16-20), 2-0 | Sportsman's Park III (3-1) | 16-20 | |
| » Starters: Steve Gromek vs Jack Kramer | Fifth | 12 out |
| Tuesday, May 28 |
| » Lost to Tigers (20-18), 6-1 | Cleveland Stadium (1-6) | 16-21 | |
| » Starters: Fred Hutchinson vs Red Embree | Fifth | 12½ out |
| Wednesday, May 29 |
| » Lost to Tigers (21-18), 4-1 | League Park II (7-6) | 16-22 | Lost 2 |
| » Starters: Hal Newhouser vs Allie Reynolds | Fifth | 13½ out |
| Thursday, May 30 |
| » Defeated White Sox (14-21), 3-0 | Cleveland Stadium (2-6) | 17-22 | |
| » Starters: Joe Haynes vs Bob Feller | Fifth | 14½ out |
| » Lost to White Sox (15-21), 4-0 | Cleveland Stadium (2-7) | 17-23 | |
| » Starters: Bill Dietrich vs Steve Gromek | Fifth | 14½ out |
| Saturday, June 1 |
| » Lost to Athletics (10-31), 10-4 | Shibe Park (1-2) | 17-24 | Lost 2 |
| » Starters: Joe Krakauskas vs Russ Christopher | Seventh | 15 out |
| Monday, June 3 |
| » Defeated Athletics (10-32), 6-5 | Shibe Park (2-2) | 18-24 | |
| » Starters: Red Embree vs Phil Marchildon | Sixth | 16 out |
| » Lost to Athletics (11-32), 3-2 | Shibe Park (2-3) | 18-25 | |
| » Starters: Bob Lemon vs Dick Fowler | Sixth | 16 out |
| Tuesday, June 4 |
| » Defeated Senators (22-19), 10-2 | Griffith Stadium (1-3) | 19-25 | |
| » Starters: Bob Feller vs Mickey Haefner | Fifth | 16 out |
| Wednesday, June 5 |
| » Lost to Senators (23-19), 5-1 | Griffith Stadium (1-4) | 19-26 | |
| » Starters: Steve Gromek vs Roger Wolff | Fifth | 16½ out |
| Thursday, June 6 |
| » Lost to Senators (24-19), 4-0 | Griffith Stadium (1-5) | 19-27 | Lost 2 |
| » Starters: Bob Lemon vs Sid Hudson | Fifth | 17½ out |
| Friday, June 7 |
| » Lost to Yankees (32-17), 6-5 | Yankee Stadium (1-3) | 19-28 | Lost 3 |
| » Starters: Red Embree vs Bill Bevens | Fifth | 18 out |
| Saturday, June 8 |
| » Defeated Yankees (32-18), 2-1 | Yankee Stadium (2-3) | 20-28 | |
| » Starters: Bob Feller vs Cuddles Marshall | Fifth | 18 out |
| Sunday, June 9 |
| » Defeated Yankees (32-19), 9-5 | Yankee Stadium (3-3) | 21-28 | Won 2 |
| » Starters: Don Black vs Joe Page | Fifth | 19 out |
| » Lost to Yankees (33-19), 7-4 | Yankee Stadium (3-4) | 21-29 | |
| » Starters: Allie Reynolds vs Spud Chandler | Fifth | 19 out |
| » Major-league debuts: Gus Niarhos (Yankees) |
| Monday, June 10 |
| » Lost to Red Sox (40-9), 6-3 | Fenway Park (0-3) | 21-30 | Lost 2 |
| » Starters: Steve Gromek vs Bill Butland | Fifth | 20 out |
| Tuesday, June 11 |
| » Lost to Red Sox (41-9), 10-5 | Fenway Park (0-4) | 21-31 | Lost 3 |
| » Starters: Red Embree vs Charlie Wagner | Sixth | 21 out |
| Wednesday, June 12 |
| » Defeated Red Sox (41-10), 7-2 | Fenway Park (1-4) | 22-31 | |
| » Starters: Bob Feller vs Jim Bagby | Sixth | 20 out |
| Friday, June 14 |
| » Lost to Athletics (15-37), 5-3 | Cleveland Stadium (2-8) | 22-32 | |
| » Starters: Dick Fowler vs Allie Reynolds | Sixth | 20 out |
| Saturday, June 15 |
| » Defeated Athletics (15-38), 4-1 | League Park II (8-6) | 23-32 | |
| » Starters: Phil Marchildon vs Don Black | Sixth | 19 out |
| Sunday, June 16 |
| » Defeated Athletics (15-39), 2-1 | Cleveland Stadium (3-8) | 24-32 | Won 2 |
| » Starters: Bob Savage vs Bob Feller | Fifth | 18 out |
| » Defeated Athletics (15-40), 3-2 | Cleveland Stadium (4-8) | 25-32 | Won 3 |
| » Starters: Lou Knerr vs Red Embree | Fifth | 18 out |
| Thursday, June 20 |
| » Defeated Senators (29-26), 4-3 | Cleveland Stadium (5-8) | 26-32 | Won 4 |
| » Starters: Bobo Newsom vs Allie Reynolds | Fifth | 16 out |
| Friday, June 21 |
| » Lost to Red Sox (43-16), 1-0 | Cleveland Stadium (5-9) | 26-33 | |
| » Starters: Tex Hughson vs Bob Feller | Fifth | 17 out |
| Saturday, June 22 |
| » Defeated Red Sox (43-17), 4-3 | League Park II (9-6) | 27-33 | |
| » Starters: Dave Ferriss vs Red Embree | Fifth | 16 out |
| Sunday, June 23 |
| » Lost to Red Sox (44-17), 5-1 | Cleveland Stadium (5-10) | 27-34 | |
| » Starters: Mickey Harris vs Steve Gromek | Sixth | 18 out |
| » Lost to Red Sox (45-17), 6-0 | Cleveland Stadium (5-11) | 27-35 | Lost 2 |
| » Starters: Bill Zuber vs Don Black | Sixth | 18 out |
| Monday, June 24 |
| » Lost to Yankees (40-25), 1-0 | Cleveland Stadium (5-12) | 27-36 | Lost 3 |
| » Starters: Bill Bevens vs Allie Reynolds | Sixth | 18½ out |
| Tuesday, June 25 |
| » Defeated Yankees (40-26), 8-3 | League Park II (10-6) | 28-36 | |
| » Starters: Tommy Byrne vs Bob Feller | Sixth | 18½ out |
| Wednesday, June 26 |
| » Lost to Yankees (41-26), 8-4 | League Park II (10-7) | 28-37 | |
| » Starters: Spud Chandler vs Red Embree | Sixth | 19 out |
| Friday, June 28 |
| » Defeated White Sox (25-37), 7-2 | Comiskey Park I (3-0) | 29-37 | |
| » Starters: Steve Gromek vs Ralph Hamner | Sixth | 19 out |
| Saturday, June 29 |
| » Defeated White Sox (25-38), 2-0 | Comiskey Park I (4-0) | 30-37 | Won 2 |
| » Starters: Bob Feller vs Orval Grove | Sixth | 19 out |
| Sunday, June 30 |
| » Lost to White Sox (26-38), 7-3 | Comiskey Park I (4-1) | 30-38 | |
| » Starters: Allie Reynolds vs Eddie Smith | Sixth | 19½ out |
| » Tied White Sox, 5-5 | Comiskey Park I (4-1) | 30-38 | |
| » Starters: Red Embree vs Ed Lopat | Sixth | 19½ out |
| Monday, July 1 |
| » Defeated Browns (31-37), 6-4 | Cleveland Stadium (6-12) | 31-38 | |
| » Starters: Sam Zoldak vs Mel Harder | Sixth | 19 out |
| Tuesday, July 2 |
| » Defeated Browns (31-38), 4-2 | League Park II (11-7) | 32-38 | Won 2 |
| » Starters: Tex Shirley vs Joe Krakauskas | Fifth | 18 out |
| Wednesday, July 3 |
| » Defeated Browns (31-39), 6-0 | League Park II (12-7) | 33-38 | Won 3 |
| » Starters: Denny Galehouse vs Bob Feller | Fifth | 17 out |
| Thursday, July 4 |
| » Lost to Tigers (39-31), 8-4 | Tiger Stadium (1-2) | 33-39 | |
| » Starters: Steve Gromek vs Fred Hutchinson | Fifth | 17 out |
| » Defeated Tigers (39-32), 9-8 | Tiger Stadium (2-2) | 34-39 | |
| » Starters: Allie Reynolds vs Stubby Overmire | Fifth | 17 out |
| Friday, July 5 |
| » Lost to Tigers (40-32), 7-5 | Tiger Stadium (2-3) | 34-40 | |
| » Starters: Red Embree vs Virgil Trucks | Sixth | 18 out |
| Saturday, July 6 |
| » Lost to White Sox (28-43), 3-2 | Cleveland Stadium (6-13) | 34-41 | Lost 2 |
| » Starters: Joe Haynes vs Mel Harder | Sixth | 18 out |
| Sunday, July 7 |
| » Defeated White Sox (28-44), 3-2 | Cleveland Stadium (7-13) | 35-41 | |
| » Starters: Orval Grove vs Bob Feller | Fifth | 19 out |
| » Lost to White Sox (29-44), 5-0 | Cleveland Stadium (7-14) | 35-42 | |
| » Starters: Ed Lopat vs Les Webber | Fifth | 19 out |
| Thursday, July 11 |
| » Lost to Yankees (48-31), 9-1 | Yankee Stadium (3-5) | 35-43 | Lost 2 |
| » Starters: Bob Feller vs Spud Chandler | Sixth | 20 out |
| Saturday, July 13 |
| » Defeated Yankees (48-32), 3-2 | Yankee Stadium (4-5) | 36-43 | |
| » Starters: Allie Reynolds vs Bill Bevens | Sixth | 20½ out |
| Sunday, July 14 |
| » Lost to Red Sox (58-23), 11-10 | Fenway Park (1-5) | 36-44 | |
| » Starters: Steve Gromek vs Joe Dobson | Sixth | 22½ out |
| » Lost to Red Sox (59-23), 6-4 | Fenway Park (1-6) | 36-45 | Lost 2 |
| » Starters: Red Embree vs Bill Zuber | Sixth | 22½ out |
| Tuesday, July 16 |
| » Defeated Red Sox (59-24), 6-3 | Fenway Park (2-6) | 37-45 | |
| » Starters: Bob Feller vs Tex Hughson | Fifth | 21½ out |
| Wednesday, July 17 |
| » Defeated Athletics (25-56), 8-2 | Shibe Park (3-3) | 38-45 | Won 2 |
| » Starters: Allie Reynolds vs Lou Knerr | Fifth | 22 out |
| Thursday, July 18 |
| » Defeated Athletics (25-57), 7-3 | Shibe Park (4-3) | 39-45 | Won 3 |
| » Starters: Les Webber vs Russ Christopher | Fifth | 22 out |
| Friday, July 19 |
| » Defeated Athletics (25-58), 6-1 | Shibe Park (5-3) | 40-45 | Won 4 |
| » Starters: Mel Harder vs Bob Savage | Fifth | 22 out |
| Saturday, July 20 |
| » Defeated Senators (42-42), 10-2 | Griffith Stadium (2-5) | 41-45 | Won 5 |
| » Starters: Bob Feller vs Sid Hudson | Fifth | 21 out |
| Sunday, July 21 |
| » Lost to Senators (43-42), 2-1 | Griffith Stadium (2-6) | 41-46 | |
| » Starters: Charlie Gassaway vs Mickey Haefner | Fifth | 23 out |
| » Lost to Senators (44-42), 7-5 | Griffith Stadium (2-7) | 41-47 | Lost 2 |
| » Starters: Red Embree vs Early Wynn | Fifth | 23 out |
| Tuesday, July 23 |
| » Defeated Athletics (26-61), 2-0 | Cleveland Stadium (8-14) | 42-47 | |
| » Starters: Phil Marchildon vs Allie Reynolds | Fifth | 22 out |
| Wednesday, July 24 |
| » Defeated Athletics (26-62), 1-0 | League Park II (13-7) | 43-47 | Won 2 |
| » Starters: Bob Savage vs Bob Feller | Fifth | 22 out |
| Thursday, July 25 |
| » Defeated Athletics (26-63), 9-8 | League Park II (14-7) | 44-47 | Won 3 |
| » Starters: Lou Knerr vs Mel Harder | Fifth | 21 out |
| Friday, July 26 |
| » Lost to Senators (47-43), 5-4 | Cleveland Stadium (8-15) | 44-48 | |
| » Starters: Mickey Haefner vs Steve Gromek | Fifth | 22 out |
| Saturday, July 27 |
| » Lost to Senators (48-43), 3-2 | League Park II (14-8) | 44-49 | Lost 2 |
| » Starters: Sid Hudson vs Red Embree | Fifth | 23 out |
| Sunday, July 28 |
| » Defeated Senators (48-44), 2-0 | Cleveland Stadium (9-15) | 45-49 | |
| » Starters: Bobo Newsom vs Bob Feller | Fifth | 22 out |
| » Defeated Senators (48-45), 7-4 | Cleveland Stadium (10-15) | 46-49 | Won 2 |
| » Starters: Dutch Leonard vs Allie Reynolds | Fifth | 22 out |
| Monday, July 29 |
| » Lost to Senators (49-45), 2-1 | League Park II (14-9) | 46-50 | |
| » Starters: Ray Scarborough vs Charlie Gassaway | Fifth | 23 out |
| » Lost to Senators (50-45), 8-4 | League Park II (14-10) | 46-51 | Lost 2 |
| » Starters: Early Wynn vs Joe Krakauskas | Fifth | 23 out |
| Tuesday, July 30 |
| » Lost to Red Sox (70-28), 4-0 | Cleveland Stadium (10-16) | 46-52 | Lost 3 |
| » Starters: Dave Ferriss vs Steve Gromek | Fifth | 24 out |
| Wednesday, July 31 |
| » Defeated Red Sox (70-29), 4-1 | League Park II (15-10) | 47-52 | |
| » Starters: Mickey Harris vs Bob Feller | Fifth | 23 out |
| Thursday, August 1 |
| » Defeated Red Sox (70-30), 2-1 | Cleveland Stadium (11-16) | 48-52 | Won 2 |
| » Starters: Joe Dobson vs Mel Harder | Fifth | 22 out |
| Friday, August 2 |
| » Defeated Yankees (58-42), 3-0 | Cleveland Stadium (12-16) | 49-52 | Won 3 |
| » Starters: Tiny Bonham vs Allie Reynolds | Fifth | 21 out |
| Sunday, August 4 |
| » Lost to Yankees (59-42), 2-0 | Cleveland Stadium (12-17) | 49-53 | |
| » Starters: Bill Bevens vs Bob Feller | Fifth | 22½ out |
| Former Indian Carl Lind dies in New York, NY at the age of 43. |
| Tuesday, August 6 |
| » Lost to White Sox (44-59), 11-1 | Comiskey Park I (4-2) | 49-54 | Lost 2 |
| » Starters: Steve Gromek vs Ed Lopat | Fifth | 23½ out |
| Wednesday, August 7 |
| » Lost to White Sox (45-59), 4-3 | Comiskey Park I (4-3) | 49-55 | Lost 3 |
| » Starters: Allie Reynolds vs Johnny Rigney | Fifth | 24 out |
| Thursday, August 8 |
| » Defeated White Sox (45-60), 5-0 | Comiskey Park I (5-3) | 50-55 | |
| » Starters: Bob Feller vs Orval Grove | Fifth | 25 out |
| » Lost to White Sox (46-60), 7-6 | Comiskey Park I (5-4) | 50-56 | |
| » Starters: Red Embree vs Frank Papish | Fifth | 25 out |
| Friday, August 9 |
| » Defeated Browns (46-58), 5-4 | Sportsman's Park III (4-1) | 51-56 | |
| » Starters: Charlie Gassaway vs Denny Galehouse | Fifth | 25 out |
| Future Indian Gerry Moses is born in Yazoo City, MS. |
| Saturday, August 10 |
| » Defeated Browns (46-59), 5-3 | Sportsman's Park III (5-1) | 52-56 | Won 2 |
| » Starters: Mel Harder vs Nels Potter | Fifth | 24 out |
| Sunday, August 11 |
| » Lost to Browns (47-59), 3-2 | Sportsman's Park III (5-2) | 52-57 | |
| » Starters: Red Embree vs Jack Kramer | Fifth | 24 out |
| » Defeated Browns (47-60), 4-3 | Sportsman's Park III (6-2) | 53-57 | |
| » Starters: Allie Reynolds vs Bob Muncrief | Fifth | 24 out |
| Future Indian Mike Hedlund is born in Dallas, TX. Future Indian Eddie Leon is born in Tucson, AZ. |
| Monday, August 12 |
| » Lost to Tigers (60-46), 3-2 | League Park II (15-11) | 53-58 | |
| » Starters: Al Benton vs Steve Gromek | Fifth | 24½ out |
| Tuesday, August 13 |
| » Lost to Tigers (61-46), 1-0 | Cleveland Stadium (12-18) | 53-59 | Lost 2 |
| » Starters: Dizzy Trout vs Bob Feller | Fifth | 25½ out |
| Wednesday, August 14 |
| » Defeated Tigers (61-47), 6-5 | League Park II (16-11) | 54-59 | |
| » Starters: Fred Hutchinson vs Charlie Gassaway | Fifth | 25½ out |
| Thursday, August 15 |
| » Defeated Browns (47-63), 3-2 | Cleveland Stadium (13-18) | 55-59 | Won 2 |
| » Starters: Jack Kramer vs Allie Reynolds | Fifth | 24½ out |
| Future Indian Joe Lis is born in Somerville, NJ. |
| Saturday, August 17 |
| » Lost to White Sox (51-63), 4-1 | Cleveland Stadium (13-19) | 55-60 | |
| » Starters: Joe Haynes vs Bob Feller | Fifth | 26 out |
| Sunday, August 18 |
| » Lost to White Sox (52-63), 6-4 | Cleveland Stadium (13-20) | 55-61 | Lost 2 |
| » Starters: Orval Grove vs Mel Harder | Fifth | 26 out |
| » Defeated White Sox (52-64), 13-3 | Cleveland Stadium (14-20) | 56-61 | |
| » Starters: Ralph Hamner vs Red Embree | Fifth | 26 out |
| » Major-league debuts: Jackie Price (Indians) |
| Tuesday, August 20 |
| » Lost to Senators (58-60), 5-4 | Griffith Stadium (2-8) | 56-62 | |
| » Starters: Bob Feller vs Mickey Haefner | Fifth | 26½ out |
| Wednesday, August 21 |
| » Lost to Senators (59-60), 4-3 | Griffith Stadium (2-9) | 56-63 | Lost 2 |
| » Starters: Charlie Gassaway vs Early Wynn | Fifth | 27½ out |
| Thursday, August 22 |
| » Lost to Athletics (38-81), 8-6 | Shibe Park (5-4) | 56-64 | Lost 3 |
| » Starters: Allie Reynolds vs Dick Fowler | Fifth | 27½ out |
| Friday, August 23 |
| » Lost to Athletics (39-81), 1-0 | Shibe Park (5-5) | 56-65 | Lost 4 |
| » Starters: Mel Harder vs Jesse Flores | Fifth | 28 out |
| Saturday, August 24 |
| » Defeated Athletics (39-82), 5-0 | Shibe Park (6-5) | 57-65 | |
| » Starters: Bob Feller vs Lum Harris | Fifth | 27½ out |
| Sunday, August 25 |
| » Lost to Red Sox (86-38), 2-1 | Fenway Park (2-7) | 57-66 | |
| » Starters: Red Embree vs Dave Ferriss | Fifth | 29½ out |
| » Lost to Red Sox (87-38), 13-6 | Fenway Park (2-8) | 57-67 | Lost 2 |
| » Starters: Allie Reynolds vs Joe Dobson | Fifth | 29½ out |
| Monday, August 26 |
| » Lost to Red Sox (88-38), 5-1 | Fenway Park (2-9) | 57-68 | Lost 3 |
| » Starters: Bob Lemon vs Tex Hughson | Fifth | 30½ out |
| Wednesday, August 28 |
| » Lost to Yankees (74-52), 4-0 | Yankee Stadium (4-6) | 57-69 | Lost 4 |
| » Starters: Bob Feller vs Tiny Bonham | Fifth | 30½ out |
| Thursday, August 29 |
| » Lost to Yankees (75-52), 9-1 | Yankee Stadium (4-7) | 57-70 | Lost 5 |
| » Starters: Steve Gromek vs Randy Gumpert | Fifth | 30½ out |
| Saturday, August 31 |
| » Defeated White Sox (57-71), 3-2 | Comiskey Park I (6-4) | 58-70 | |
| » Starters: Mel Harder vs Ed Lopat | Fifth | 31½ out |
| Sunday, September 1 |
| » Lost to White Sox (58-71), 4-1 | Comiskey Park I (6-5) | 58-71 | |
| » Starters: Bob Feller vs Joe Haynes | Fifth | 32½ out |
| Monday, September 2 |
| » Lost to Browns (54-72), 9-2 | Sportsman's Park III (6-3) | 58-72 | Lost 2 |
| » Starters: Allie Reynolds vs Denny Galehouse | Sixth | 34 out |
| » Tied Browns, 2-2 | Sportsman's Park III (6-3) | 58-72 | |
| » Starters: Red Embree vs Sam Zoldak | Sixth | 34 out |
| Tuesday, September 3 |
| » Defeated Browns (54-73), 5-3 | Sportsman's Park III (7-3) | 59-72 | |
| » Starters: Bob Lemon vs Stan Ferens | Fifth | 33 out |
| » Defeated Browns (54-74), 7-3 | Sportsman's Park III (8-3) | 60-72 | Won 2 |
| » Starters: Charlie Gassaway vs Tom Ferrick | Fifth | 33 out |
| Wednesday, September 4 |
| » Lost to Tigers (73-55), 4-1 | Tiger Stadium (2-4) | 60-73 | |
| » Starters: Steve Gromek vs Hal Newhouser | Fifth | 34 out |
| Thursday, September 5 |
| » Lost to Tigers (74-55), 10-0 | Tiger Stadium (2-5) | 60-74 | Lost 2 |
| » Starters: Bob Feller vs Fred Hutchinson | Sixth | 35 out |
| » Major-league debuts: Johnny Groth (Tigers) |
| Friday, September 6 |
| » Lost to Tigers (75-55), 9-0 | Tiger Stadium (2-6) | 60-75 | Lost 3 |
| » Starters: Mel Harder vs Dizzy Trout | Sixth | 35 out |
| Saturday, September 7 |
| » Lost to Browns (56-75), 4-1 | League Park II (16-12) | 60-76 | Lost 4 |
| » Starters: Sam Zoldak vs Allie Reynolds | Sixth | 35 out |
| Sunday, September 8 |
| » Lost to Browns (57-75), 4-1 | Cleveland Stadium (14-21) | 60-77 | Lost 5 |
| » Starters: Jack Kramer vs Red Embree | Sixth | 34½ out |
| » Defeated Browns (57-76), 3-2 | Cleveland Stadium (15-21) | 61-77 | |
| » Starters: Denny Galehouse vs Bob Feller | Sixth | 34½ out |
| Monday, September 9 |
| » Major-league debuts: Sheldon Jones (Giants) |
| Tuesday, September 10 |
| » Defeated Yankees (79-59), 4-2 | League Park II (17-12) | 62-77 | Won 2 |
| » Starters: Spud Chandler vs Steve Gromek | Sixth | 33½ out |
| Wednesday, September 11 |
| » Defeated Yankees (79-60), 11-2 | League Park II (18-12) | 63-77 | Won 3 |
| » Starters: Tiny Bonham vs Allie Reynolds | Sixth | 32½ out |
| » Major-league debuts: Eddie Bockman (Yankees) |
| Thursday, September 12 |
| » Defeated Red Sox (96-46), 4-1 | League Park II (19-12) | 64-77 | Won 4 |
| » Starters: Jim Bagby vs Bob Feller | Sixth | 31½ out |
| Friday, September 13 |
| » Lost to Red Sox (97-46), 1-0 | League Park II (19-13) | 64-78 | |
| » Starters: Tex Hughson vs Red Embree | Sixth | 32½ out |
| Sunday, September 15 |
| » Defeated Athletics (48-95), 8-1 | Cleveland Stadium (16-21) | 65-78 | |
| » Starters: Joe Coleman vs Bob Lemon | Sixth | 32½ out |
| » Lost to Athletics (49-95), 2-0 | Cleveland Stadium (16-22) | 65-79 | |
| » Starters: Bill McCahan vs Bob Feller | Sixth | 32½ out |
| » Major-league debuts: Dale Mitchell (Indians) |
| Wednesday, September 18 |
| » Lost to Senators (71-74), 8-1 | League Park II (19-14) | 65-80 | Lost 2 |
| » Starters: Mickey Haefner vs Ralph McCabe | Sixth | 33½ out |
| Thursday, September 19 |
| » Defeated Senators (71-75), 5-1 | League Park II (20-14) | 66-80 | |
| » Starters: Ray Scarborough vs Bob Feller | Sixth | 32½ out |
| Future Indian Ron Lolich is born in Portland, OR. |
| Friday, September 20 |
| » Lost to Tigers (85-59), 15-1 | League Park II (20-15) | 66-81 | |
| » Starters: Fred Hutchinson vs Allie Reynolds | Sixth | 33 out |
| Future Indian Roric Harrison is born in Los Angeles, CA. |
| Saturday, September 21 |
| » Lost to Tigers (86-59), 5-3 | League Park II (20-16) | 66-82 | Lost 2 |
| » Starters: Dizzy Trout vs Bob Kuzava | Sixth | 34 out |
| » Major-league debuts: Bob Kuzava (Indians) |
| Sunday, September 22 |
| » Lost to Tigers (87-59), 3-0 | Cleveland Stadium (16-23) | 66-83 | Lost 3 |
| » Starters: Hal Newhouser vs Bob Feller | Sixth | 35½ out |
| » Lost to Tigers (88-59), 4-3 | Cleveland Stadium (16-24) | 66-84 | Lost 4 |
| » Starters: Al Benton vs Steve Gromek | Sixth | 35½ out |
| Wednesday, September 25 |
| » Lost to White Sox (72-79), 4-1 | Cleveland Stadium (16-25) | 66-85 | Lost 5 |
| » Starters: Joe Haynes vs Bob Feller | Sixth | 37 out |
| Friday, September 27 |
| » Defeated Tigers (91-61), 9-8 | Tiger Stadium (3-6) | 67-85 | |
| » Starters: Bob Kuzava vs Ted Gray | Sixth | 37 out |
| Saturday, September 28 |
| » Lost to Tigers (92-61), 7-3 | Tiger Stadium (3-7) | 67-86 | |
| » Starters: Ray Flanigan vs Hal White | Sixth | 37 out |
| Sunday, September 29 |
| » Defeated Tigers (92-62), 4-1 | Tiger Stadium (4-7) | 68-86 | |
| » Starters: Bob Feller vs Hal Newhouser | Sixth | 36 out |
| Tuesday, October 8 |
| Future Indian Ralph Gagliano is born in Memphis, TN. |
| T |
