| Sunday, January 14 |
| Former White Sox Ted Blankenship dies in Atoka, OK at the age of 44. |
| Tuesday, April 17 |
| » Defeated Indians (0-1), 5-2 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Thornton Lee vs Allie Reynolds | First | -- |
| Wednesday, April 18 |
| » Major-league debuts: Ken Gables and Bill Salkeld (Pirates) |
| Thursday, April 19 |
| » Defeated Indians (0-2), 14-6 | League Park II (1-0) | 2-0 | Won 2 |
| » Starters: Bill Dietrich vs Jim Bagby | Second | ½ out |
| Friday, April 20 |
| » Defeated Browns (1-3), 3-2 | Comiskey Park I (1-0) | 3-0 | Won 3 |
| » Starters: Al Hollingsworth vs Ed Lopat | Second | ½ out |
| Sunday, April 22 |
| » Defeated Browns (1-4), 4-3 | Comiskey Park I (2-0) | 4-0 | Won 4 |
| » Starters: Jack Kramer vs Joe Haynes | First | -- |
| » Defeated Browns (1-5), 5-3 | Comiskey Park I (3-0) | 5-0 | Won 5 |
| » Starters: Sig Jakucki vs Orval Grove | First | -- |
| Sunday, April 29 |
| » Lost to Browns (3-5), 3-2 | Sportsman's Park III (0-1) | 5-1 | |
| » Starters: Thornton Lee vs Sig Jakucki | First | -- |
| » Lost to Browns (4-5), 10-4 | Sportsman's Park III (0-2) | 5-2 | Lost 2 |
| » Starters: Ed Lopat vs Al Hollingsworth | First | -- |
| Tuesday, May 1 |
| » Defeated Tigers (6-4), 5-0 | Tiger Stadium (1-0) | 6-2 | |
| » Starters: Joe Haynes vs Walter Wilson | First | -- |
| Wednesday, May 2 |
| » Lost to Tigers (7-4), 2-1 | Tiger Stadium (1-1) | 6-3 | |
| » Starters: Orval Grove vs Al Benton | Second | 1½ out |
| Saturday, May 5 |
| » Defeated Indians (3-8), 3-2 | Comiskey Park I (4-0) | 7-3 | |
| » Starters: Al Smith vs Thornton Lee | First | -- |
| Sunday, May 6 |
| » Defeated Indians (3-9), 3-2 | Comiskey Park I (5-0) | 8-3 | Won 2 |
| » Starters: Jim Bagby vs Ed Lopat | First | -- |
| » Defeated Indians (3-10), 6-4 | Comiskey Park I (6-0) | 9-3 | Won 3 |
| » Starters: Steve Gromek vs Joe Haynes | First | -- |
| Tuesday, May 8 |
| » Lost to Indians (4-10), 7-1 | Comiskey Park I (6-1) | 9-4 | |
| » Starters: Red Embree vs Orval Grove | First | -- |
| » Major-league debuts: Frank Papish (White Sox) |
| Wednesday, May 9 |
| » Defeated Athletics (7-10), 6-4 | Comiskey Park I (7-1) | 10-4 | |
| » Starters: Don Black vs Thornton Lee | First | -- |
| Friday, May 11 |
| » Lost to Athletics (8-10), 5-2 | Comiskey Park I (7-2) | 10-5 | |
| » Starters: Russ Christopher vs Ed Lopat | First | -- |
| Saturday, May 12 |
| » Lost to Senators (10-10), 3-0 | Comiskey Park I (7-3) | 10-6 | Lost 2 |
| » Starters: Dutch Leonard vs Joe Haynes | Second | 1 out |
| Sunday, May 13 |
| » Defeated Senators (10-11), 5-1 | Comiskey Park I (8-3) | 11-6 | |
| » Starters: Mickey Haefner vs Thornton Lee | First | -- |
| » Defeated Senators (10-12), 4-2 | Comiskey Park I (9-3) | 12-6 | Won 2 |
| » Starters: Alex Carrasquel vs Orval Grove | First | -- |
| Thursday, May 17 |
| » Major-league debuts: Cy Buker (Dodgers) |
| Friday, May 18 |
| » Lost to Red Sox (9-12), 2-0 | Comiskey Park I (9-4) | 12-7 | |
| » Starters: Dave Ferriss vs Joe Haynes | First | -- |
| Saturday, May 19 |
| » Defeated Red Sox (9-13), 3-2 | Comiskey Park I (10-4) | 13-7 | |
| » Starters: Jim Wilson vs Johnny Humphries | First | -- |
| Sunday, May 20 |
| » Defeated Red Sox (9-14), 4-2 | Comiskey Park I (11-4) | 14-7 | Won 2 |
| » Starters: Rex Cecil vs Thornton Lee | First | -- |
| » Defeated Red Sox (9-15), 8-2 | Comiskey Park I (12-4) | 15-7 | Won 3 |
| » Starters: Joe Bowman vs Orval Grove | First | -- |
| Wednesday, May 23 |
| » Lost to Yankees (15-11), 5-3 | Yankee Stadium (0-1) | 15-8 | |
| » Starters: Joe Haynes vs Bill Bevens | First | -- |
| Thursday, May 24 |
| » Lost to Yankees (16-11), 6-3 | Yankee Stadium (0-2) | 15-9 | Lost 2 |
| » Starters: Orval Grove vs Atley Donald | First | -- |
| Friday, May 25 |
| » Lost to Yankees (17-11), 5-4 | Yankee Stadium (0-3) | 15-10 | Lost 3 |
| » Starters: Johnny Humphries vs Al Gettel | Second | 1½ out |
| Saturday, May 26 |
| » Lost to Yankees (18-11), 13-0 | Yankee Stadium (0-4) | 15-11 | Lost 4 |
| » Starters: Thornton Lee vs Monk Dubiel | Third | 1½ out |
| Sunday, May 27 |
| » Lost to Red Sox (12-17), 7-0 | Fenway Park (0-1) | 15-12 | Lost 5 |
| » Starters: Ed Lopat vs Dave Ferriss | Third | 3½ out |
| » Lost to Red Sox (13-17), 2-1 | Fenway Park (0-2) | 15-13 | Lost 6 |
| » Starters: Joe Haynes vs Emmett O'Neill | Third | 3½ out |
| Monday, May 28 |
| » Defeated Red Sox (13-18), 8-6 | Fenway Park (1-2) | 16-13 | |
| » Starters: Orval Grove vs Rex Cecil | Third | 3 out |
| Tuesday, May 29 |
| » Lost to Red Sox (14-18), 6-4 | Fenway Park (1-3) | 16-14 | |
| » Starters: Buck Ross vs Pinky Woods | Third | 4 out |
| Future White Sox Blue Moon Odom is born in Macon, GA. |
| Wednesday, May 30 |
| » Defeated Athletics (12-21), 5-2 | Shibe Park (1-0) | 17-14 | |
| » Starters: Thornton Lee vs Bobo Newsom | Third | 4 out |
| » Lost to Athletics (13-21), 4-2 | Shibe Park (1-1) | 17-15 | |
| » Starters: Johnny Humphries vs Russ Christopher | Third | 4 out |
| Thursday, May 31 |
| » Lost to Athletics (14-21), 3-2 | Shibe Park (1-2) | 17-16 | Lost 2 |
| » Starters: Ed Lopat vs Don Black | Third | 4 out |
| Friday, June 1 |
| » Defeated Senators (15-20), 11-9 | Griffith Stadium (1-0) | 18-16 | |
| » Starters: Joe Haynes vs Johnny Niggeling | Third | 4 out |
| Saturday, June 2 |
| » Lost to Senators (16-20), 8-1 | Griffith Stadium (1-1) | 18-17 | |
| » Starters: Orval Grove vs Dutch Leonard | Fourth | 4 out |
| Sunday, June 3 |
| » Lost to Senators (17-20), 3-1 | Griffith Stadium (1-2) | 18-18 | Lost 2 |
| » Starters: Thornton Lee vs Roger Wolff | Third | 4 out |
| » Defeated Senators (17-21), 5-1 | Griffith Stadium (2-2) | 19-18 | |
| » Starters: Johnny Humphries vs Marino Pieretti | Third | 4 out |
| Tuesday, June 5 |
| » Lost to Browns (19-17), 2-1 | Comiskey Park I (12-5) | 19-19 | |
| » Starters: Al Hollingsworth vs Joe Haynes | Fourth | 4½ out |
| Wednesday, June 6 |
| » Defeated Browns (19-18), 4-0 | Comiskey Park I (13-5) | 20-19 | |
| » Starters: Sig Jakucki vs Orval Grove | Fourth | 3½ out |
| Thursday, June 7 |
| » Lost to Browns (20-18), 6-0 | Comiskey Park I (13-6) | 20-20 | |
| » Starters: Jack Kramer vs Ed Lopat | Fifth | 4½ out |
| » Lost to Browns (21-18), 6-2 | Comiskey Park I (13-7) | 20-21 | Lost 2 |
| » Starters: Tex Shirley vs Johnny Humphries | Fifth | 4½ out |
| Friday, June 8 |
| » Lost to Tigers (23-16), 2-1 | Tiger Stadium (1-2) | 20-22 | Lost 3 |
| » Starters: Thornton Lee vs Joe Orrell | Fifth | 4½ out |
| Saturday, June 9 |
| » Lost to Tigers (24-16), 7-6 | Tiger Stadium (1-3) | 20-23 | Lost 4 |
| » Starters: Joe Haynes vs Les Mueller | Sixth | 5½ out |
| Sunday, June 10 |
| » Lost to Tigers (25-16), 3-2 | Tiger Stadium (1-4) | 20-24 | Lost 5 |
| » Starters: Johnny Humphries vs Dizzy Trout | Sixth | 6 out |
| » Defeated Tigers (25-17), 9-4 | Tiger Stadium (2-4) | 21-24 | |
| » Starters: Orval Grove vs Stubby Overmire | Sixth | 6 out |
| Tuesday, June 12 |
| » Defeated Indians (20-23), 1-0 | Comiskey Park I (14-7) | 22-24 | Won 2 |
| » Starters: Al Smith vs Thornton Lee | Fifth | 5½ out |
| Wednesday, June 13 |
| » Defeated Indians (20-24), 5-3 | Comiskey Park I (15-7) | 23-24 | Won 3 |
| » Starters: Steve Gromek vs Joe Haynes | Fifth | 5½ out |
| Thursday, June 14 |
| » Defeated Indians (20-25), 4-3 | Comiskey Park I (16-7) | 24-24 | Won 4 |
| » Starters: Jim Bagby vs Orval Grove | Fifth | 4½ out |
| Saturday, June 16 |
| » Lost to Tigers (28-18), 7-5 | Comiskey Park I (16-8) | 24-25 | |
| » Starters: Stubby Overmire vs Ed Lopat | Fifth | 6½ out |
| » Lost to Tigers (29-18), 6-1 | Comiskey Park I (16-9) | 24-26 | Lost 2 |
| » Starters: Hal Newhouser vs Johnny Humphries | Fifth | 6½ out |
| Sunday, June 17 |
| » Defeated Tigers (29-19), 6-1 | Comiskey Park I (17-9) | 25-26 | |
| » Starters: Joe Orrell vs Thornton Lee | Fifth | 4½ out |
| » Defeated Tigers (29-20), 7-5 | Comiskey Park I (18-9) | 26-26 | Won 2 |
| » Starters: Les Mueller vs Joe Haynes | Fifth | 4½ out |
| Monday, June 18 |
| » Defeated Tigers (29-21), 1-0 | Comiskey Park I (19-9) | 27-26 | Won 3 |
| » Starters: Dizzy Trout vs Bill Dietrich | Fourth | 3½ out |
| Tuesday, June 19 |
| » Defeated Browns (24-25), 5-4 | Sportsman's Park III (1-2) | 28-26 | Won 4 |
| » Starters: Earl Caldwell vs Nels Potter | Fourth | 3½ out |
| Wednesday, June 20 |
| » Defeated Browns (24-26), 4-1 | Sportsman's Park III (2-2) | 29-26 | Won 5 |
| » Starters: Ed Lopat vs Al Hollingsworth | Fourth | 3½ out |
| Friday, June 22 |
| » Lost to Indians (22-29), 2-1 | Cleveland Stadium (1-1) | 29-27 | |
| » Starters: Thornton Lee vs Allie Reynolds | Fourth | 3½ out |
| » Defeated Indians (22-30), 3-0 | Cleveland Stadium (2-1) | 30-27 | |
| » Starters: Orval Grove vs Ed Klieman | Fourth | 3½ out |
| Sunday, June 24 |
| » Lost to Indians (23-30), 7-3 | Cleveland Stadium (2-2) | 30-28 | |
| » Starters: Bill Dietrich vs Steve Gromek | Fourth | 5 out |
| » Defeated Indians (23-31), 7-4 | Cleveland Stadium (3-2) | 31-28 | |
| » Starters: Ed Lopat vs Earl Henry | Fourth | 5 out |
| Wednesday, June 27 |
| » Lost to Red Sox (31-27), 11-9 | Comiskey Park I (19-10) | 31-29 | |
| » Starters: Emmett O'Neill vs Orval Grove | Third | 5 out |
| Friday, June 29 |
| » Lost to Red Sox (32-27), 4-2 | Comiskey Park I (19-11) | 31-30 | Lost 2 |
| » Starters: Dave Ferriss vs Johnny Humphries | Fourth | 5½ out |
| Saturday, June 30 |
| » Defeated Yankees (35-25), 5-1 | Comiskey Park I (20-11) | 32-30 | |
| » Starters: Tiny Bonham vs Earl Caldwell | Fifth | 5½ out |
| Sunday, July 1 |
| » Defeated Yankees (35-26), 11-4 | Comiskey Park I (21-11) | 33-30 | Won 2 |
| » Starters: Hank Borowy vs Bill Dietrich | Fourth | 5½ out |
| » Defeated Yankees (35-27), 6-5 | Comiskey Park I (22-11) | 34-30 | Won 3 |
| » Starters: Monk Dubiel vs Thornton Lee | Fourth | 5½ out |
| Monday, July 2 |
| » Defeated Yankees (35-28), 11-6 | Comiskey Park I (23-11) | 35-30 | Won 4 |
| » Starters: Bill Bevens vs Ed Lopat | Third | 5½ out |
| » Lost to Yankees (36-28), 6-1 | Comiskey Park I (23-12) | 35-31 | |
| » Starters: Bill Zuber vs Orval Grove | Third | 5½ out |
| Former White Sox Frank Grube dies in New York, NY at the age of 41. |
| Tuesday, July 3 |
| » Lost to Senators (33-30), 12-2 | Comiskey Park I (23-13) | 35-32 | Lost 2 |
| » Starters: Roger Wolff vs Earl Caldwell | Fifth | 5½ out |
| Wednesday, July 4 |
| » Lost to Senators (34-30), 5-4 | Comiskey Park I (23-14) | 35-33 | Lost 3 |
| » Starters: Marino Pieretti vs Orval Grove | Fifth | 6½ out |
| » Lost to Senators (35-30), 11-2 | Comiskey Park I (23-15) | 35-34 | Lost 4 |
| » Starters: Mickey Haefner vs Johnny Humphries | Fifth | 6½ out |
| Thursday, July 5 |
| » Lost to Senators (36-30), 5-2 | Comiskey Park I (23-16) | 35-35 | Lost 5 |
| » Starters: Dutch Leonard vs Ed Lopat | Fifth | 7½ out |
| Friday, July 6 |
| » Lost to Athletics (22-45), 1-0 | Comiskey Park I (23-17) | 35-36 | Lost 6 |
| » Starters: Jesse Flores vs Thornton Lee | Fifth | 7½ out |
| Saturday, July 7 |
| » Defeated Athletics (22-46), 1-0 | Comiskey Park I (24-17) | 36-36 | |
| » Starters: Lou Knerr vs Bill Dietrich | Fifth | 7 out |
| » Defeated Athletics (22-47), 12-4 | Comiskey Park I (25-17) | 37-36 | Won 2 |
| » Starters: Russ Christopher vs Frank Papish | Fifth | 7 out |
| Future White Sox Bill Melton is born in Gulfport, MS. |
| Sunday, July 8 |
| » Defeated Athletics (22-48), 5-4 | Comiskey Park I (26-17) | 38-36 | Won 3 |
| » Starters: Steve Gerkin vs Johnny Humphries | Fourth | 6 out |
| » Defeated Athletics (22-49), 3-2 | Comiskey Park I (27-17) | 39-36 | Won 4 |
| » Starters: Charlie Gassaway vs Orval Grove | Fourth | 6 out |
| Thursday, July 12 |
| » Lost to Senators (39-32), 4-2 | Griffith Stadium (2-3) | 39-37 | |
| » Starters: Thornton Lee vs Dutch Leonard | Fifth | 6 out |
| Friday, July 13 |
| » Lost to Senators (40-32), 3-2 | Griffith Stadium (2-4) | 39-38 | Lost 2 |
| » Starters: Ed Lopat vs Mickey Haefner | Fourth | 6 out |
| Monday, July 16 |
| » Defeated Athletics (25-51), 6-2 | Shibe Park (2-2) | 40-38 | |
| » Starters: Johnny Humphries vs Russ Christopher | Fourth | 5½ out |
| » Lost to Athletics (26-51), 7-1 | Shibe Park (2-3) | 40-39 | |
| » Starters: Orval Grove vs Bobo Newsom | Fourth | 5½ out |
| Wednesday, July 18 |
| » Lost to Red Sox (42-37), 6-2 | Fenway Park (1-4) | 40-40 | Lost 2 |
| » Starters: Bill Dietrich vs Dave Ferriss | Fifth | 7 out |
| Thursday, July 19 |
| » Defeated Red Sox (42-38), 5-3 | Fenway Park (2-4) | 41-40 | |
| » Starters: Thornton Lee vs Emmett O'Neill | Fifth | 6½ out |
| Friday, July 20 |
| » Defeated Red Sox (42-39), 6-3 | Fenway Park (3-4) | 42-40 | Won 2 |
| » Starters: Ed Lopat vs Clem Hausmann | Fifth | 5 out |
| Saturday, July 21 |
| » Lost to Yankees (42-38), 12-3 | Yankee Stadium (0-5) | 42-41 | |
| » Starters: Earl Caldwell vs Tiny Bonham | Sixth | 5½ out |
| Sunday, July 22 |
| » Defeated Yankees (42-39), 6-5 | Yankee Stadium (1-5) | 43-41 | |
| » Starters: Orval Grove vs Hank Borowy | Fourth | 5 out |
| Monday, July 23 |
| » Defeated Yankees (42-40), 1-0 | Yankee Stadium (2-5) | 44-41 | Won 2 |
| » Starters: Bill Dietrich vs Bill Zuber | Third | 4 out |
| Friday, July 27 |
| » Lost to Tigers (48-36), 1-0 | Tiger Stadium (2-5) | 44-42 | |
| » Starters: Johnny Humphries vs Hal Newhouser | Fourth | 5 out |
| Saturday, July 28 |
| » Lost to Tigers (49-36), 8-3 | Tiger Stadium (2-6) | 44-43 | Lost 2 |
| » Starters: Orval Grove vs Dizzy Trout | Fifth | 6 out |
| Sunday, July 29 |
| » Lost to Tigers (50-36), 4-2 | Tiger Stadium (2-7) | 44-44 | Lost 3 |
| » Starters: Bill Dietrich vs Al Benton | Fifth | 7 out |
| Tuesday, July 31 |
| » Lost to Indians (44-44), 6-5 | Cleveland Stadium (3-3) | 44-45 | Lost 4 |
| » Starters: Thornton Lee vs Ed Klieman | Sixth | 8 out |
| Wednesday, August 1 |
| » Defeated Indians (44-45), 2-1 | League Park II (2-0) | 45-45 | |
| » Starters: Ed Lopat vs Steve Gromek | Fourth | 8 out |
| Thursday, August 2 |
| » Lost to Indians (45-45), 13-7 | League Park II (2-1) | 45-46 | |
| » Starters: Johnny Humphries vs Allie Reynolds | Sixth | 9 out |
| Friday, August 3 |
| » Defeated Tigers (53-37), 5-0 | Comiskey Park I (28-17) | 46-46 | |
| » Starters: Stubby Overmire vs Earl Caldwell | Fifth | 8 out |
| Saturday, August 4 |
| » Defeated Tigers (53-38), 3-2 | Comiskey Park I (29-17) | 47-46 | Won 2 |
| » Starters: Hal Newhouser vs Orval Grove | Fifth | 7 out |
| Sunday, August 5 |
| » Defeated Tigers (53-39), 12-8 | Comiskey Park I (30-17) | 48-46 | Won 3 |
| » Starters: Dizzy Trout vs Bill Dietrich | Fourth | 5 out |
| » Defeated Tigers (53-40), 3-2 | Comiskey Park I (31-17) | 49-46 | Won 4 |
| » Starters: Les Mueller vs Thornton Lee | Fourth | 5 out |
| Monday, August 6 |
| » Lost to Tigers (54-40), 6-2 | Comiskey Park I (31-18) | 49-47 | |
| » Starters: Al Benton vs Ed Lopat | Fourth | 5 out |
| » Defeated Tigers (54-41), 7-0 | Comiskey Park I (32-18) | 50-47 | |
| » Starters: Zeb Eaton vs Johnny Humphries | Fourth | 5 out |
| Wednesday, August 8 |
| » Defeated Senators (54-43), 7-3 | Comiskey Park I (33-18) | 51-47 | Won 2 |
| » Starters: Marino Pieretti vs Earl Caldwell | Fourth | 4½ out |
| Thursday, August 9 |
| » Lost to Senators (55-43), 7-2 | Comiskey Park I (33-19) | 51-48 | |
| » Starters: Mickey Haefner vs Bill Dietrich | Fourth | 5½ out |
| Friday, August 10 |
| » Defeated Senators (55-44), 6-3 | Comiskey Park I (34-19) | 52-48 | |
| » Starters: Roger Wolff vs Thornton Lee | Fourth | 4½ out |
| Saturday, August 11 |
| » Lost to Senators (56-44), 11-2 | Comiskey Park I (34-20) | 52-49 | |
| » Starters: Dutch Leonard vs Orval Grove | Fourth | 5½ out |
| Sunday, August 12 |
| » Lost to Athletics (34-65), 7-0 | Comiskey Park I (34-21) | 52-50 | Lost 2 |
| » Starters: Jesse Flores vs Ed Lopat | Fourth | 6½ out |
| » Defeated Athletics (34-66), 5-3 | Comiskey Park I (35-21) | 53-50 | |
| » Starters: Don Black vs Johnny Humphries | Fourth | 6½ out |
| Monday, August 13 |
| » Defeated Athletics (34-67), 4-3 | Comiskey Park I (36-21) | 54-50 | Won 2 |
| » Starters: Bobo Newsom vs Earl Caldwell | Third | 7 out |
| Wednesday, August 15 |
| » Defeated Red Sox (51-56), 5-1 | Comiskey Park I (37-21) | 55-50 | Won 3 |
| » Starters: Pinky Woods vs Bill Dietrich | Third | 5½ out |
| » Defeated Red Sox (51-57), 11-0 | Comiskey Park I (38-21) | 56-50 | Won 4 |
| » Starters: Emmett O'Neill vs Orval Grove | Third | 5½ out |
| Thursday, August 16 |
| » Defeated Red Sox (51-58), 11-3 | Comiskey Park I (39-21) | 57-50 | Won 5 |
| » Starters: Dave Ferriss vs Thornton Lee | Third | 5½ out |
| Friday, August 17 |
| » Lost to Red Sox (52-58), 8-2 | Comiskey Park I (39-22) | 57-51 | |
| » Starters: Otie Clark vs Johnny Humphries | Third | 5½ out |
| Saturday, August 18 |
| » Defeated Red Sox (52-59), 16-1 | Comiskey Park I (40-22) | 58-51 | |
| » Starters: Randy Heflin vs Ed Lopat | Third | 4½ out |
| Sunday, August 19 |
| » Lost to Yankees (53-53), 4-2 | Comiskey Park I (40-23) | 58-52 | |
| » Starters: Tiny Bonham vs Bill Dietrich | Third | 4½ out |
| » Defeated Yankees (53-54), 2-0 | Comiskey Park I (41-23) | 59-52 | |
| » Starters: Bill Zuber vs Orval Grove | Third | 4½ out |
| Monday, August 20 |
| » Lost to Yankees (54-54), 4-1 | Comiskey Park I (41-24) | 59-53 | |
| » Starters: Monk Dubiel vs Earl Caldwell | Third | 6 out |
| Tuesday, August 21 |
| » Lost to Yankees (55-54), 3-0 | Comiskey Park I (41-25) | 59-54 | Lost 2 |
| » Starters: Red Ruffing vs Thornton Lee | Third | 7 out |
| » Lost to Yankees (56-54), 6-2 | Comiskey Park I (41-26) | 59-55 | Lost 3 |
| » Starters: Al Gettel vs Johnny Humphries | Third | 7 out |
| Wednesday, August 22 |
| » Defeated Yankees (56-55), 6-5 | Comiskey Park I (42-26) | 60-55 | |
| » Starters: Ken Holcombe vs Ed Lopat | Third | 7 out |
| Friday, August 24 |
| » Lost to Browns (60-55), 3-1 | Sportsman's Park III (2-3) | 60-56 | |
| » Starters: Bill Dietrich vs Al Hollingsworth | Fourth | 7½ out |
| Saturday, August 25 |
| » Lost to Browns (61-55), 6-2 | Sportsman's Park III (2-4) | 60-57 | Lost 2 |
| » Starters: Orval Grove vs Sig Jakucki | Fourth | 8 out |
| Sunday, August 26 |
| » Lost to Browns (62-55), 3-2 | Sportsman's Park III (2-5) | 60-58 | Lost 3 |
| » Starters: Frank Papish vs Bob Muncrief | Sixth | 8 out |
| » Lost to Browns (63-55), 4-1 | Sportsman's Park III (2-6) | 60-59 | Lost 4 |
| » Starters: Johnny Humphries vs Nels Potter | Sixth | 8 out |
| Monday, August 27 |
| » Lost to Browns (64-55), 8-7 | Sportsman's Park III (2-7) | 60-60 | Lost 5 |
| » Starters: Ed Lopat vs Tex Shirley | Sixth | 8½ out |
| Tuesday, August 28 |
| » Lost to Indians (62-57), 8-2 | Comiskey Park I (42-27) | 60-61 | Lost 6 |
| » Starters: Bob Feller vs Bill Dietrich | Sixth | 9½ out |
| Thursday, August 30 |
| » Tied Indians, 4-4 | Comiskey Park I (42-27) | 60-61 | |
| » Starters: Pete Center vs Orval Grove | Sixth | 9 out |
| Saturday, September 1 |
| » Defeated Browns (65-57), 5-3 | Comiskey Park I (43-27) | 61-61 | |
| » Starters: Tex Shirley vs Thornton Lee | Sixth | 9 out |
| » Lost to Browns (66-57), 3-0 | Comiskey Park I (43-28) | 61-62 | |
| » Starters: Nels Potter vs Earl Caldwell | Sixth | 9 out |
| Sunday, September 2 |
| » Defeated Browns (66-58), 6-0 | Comiskey Park I (44-28) | 62-62 | |
| » Starters: Al Hollingsworth vs Ed Lopat | Sixth | 8½ out |
| » Lost to Browns (67-58), 3-2 | Comiskey Park I (44-29) | 62-63 | |
| » Starters: Jack Kramer vs Frank Papish | Sixth | 8½ out |
| » Major-league debuts: Cliff Fannin (Browns) |
| Monday, September 3 |
| » Lost to Tigers (71-54), 6-5 | Tiger Stadium (2-8) | 62-64 | Lost 2 |
| » Starters: Johnny Humphries vs Tommy Bridges | Sixth | 10½ out |
| » Lost to Tigers (72-54), 6-5 | Tiger Stadium (2-9) | 62-65 | Lost 3 |
| » Starters: Orval Grove vs Al Benton | Sixth | 10½ out |
| Wednesday, September 5 |
| » Defeated Athletics (40-86), 15-6 | Shibe Park (3-3) | 63-65 | |
| » Starters: Joe Haynes vs Don Black | Sixth | 10 out |
| » Defeated Athletics (40-87), 6-5 | Shibe Park (4-3) | 64-65 | Won 2 |
| » Starters: Earl Caldwell vs Bobo Newsom | Sixth | 10 out |
| Thursday, September 6 |
| » Lost to Athletics (41-87), 6-5 | Shibe Park (4-4) | 64-66 | |
| » Starters: Thornton Lee vs Lou Knerr | Sixth | 10 out |
| » Defeated Athletics (41-88), 2-1 | Shibe Park (5-4) | 65-66 | |
| » Starters: Orval Grove vs Russ Christopher | Sixth | 10 out |
| Friday, September 7 |
| » Lost to Athletics (42-88), 4-3 | Shibe Park (5-5) | 65-67 | |
| » Starters: Ed Lopat vs Charlie Bowles | Sixth | 11½ out |
| » Lost to Athletics (43-88), 9-2 | Shibe Park (5-6) | 65-68 | Lost 2 |
| » Starters: Bill Dietrich vs Charlie Gassaway | Sixth | 11½ out |
| Saturday, September 8 |
| » Lost to Athletics (44-88), 9-0 | Shibe Park (5-7) | 65-69 | Lost 3 |
| » Starters: Buck Ross vs Jesse Flores | Sixth | 12½ out |
| Future White Sox Ossie Blanco is born in Caracas, Venezuela. |
| Sunday, September 9 |
| » Lost to Senators (78-59), 4-2 | Griffith Stadium (2-5) | 65-70 | Lost 4 |
| » Starters: Johnny Humphries vs Mickey Haefner | Sixth | 14 out |
| » Lost to Senators (79-59), 5-4 | Griffith Stadium (2-6) | 65-71 | Lost 5 |
| » Starters: Frank Papish vs Alex Carrasquel | Sixth | 14 out |
| Monday, September 10 |
| » Lost to Senators (80-59), 10-4 | Griffith Stadium (2-7) | 65-72 | Lost 6 |
| » Starters: Thornton Lee vs Dutch Leonard | Sixth | 14 out |
| » Defeated Senators (80-60), 9-4 | Griffith Stadium (3-7) | 66-72 | |
| » Starters: Earl Caldwell vs Marino Pieretti | Sixth | 14 out |
| Tuesday, September 11 |
| » Defeated Senators (80-61), 2-1 | Griffith Stadium (4-7) | 67-72 | Won 2 |
| » Starters: Thornton Lee vs Johnny Niggeling | Sixth | 14 out |
| Wednesday, September 12 |
| » Lost to Yankees (71-65), 3-1 | Yankee Stadium (2-6) | 67-73 | |
| » Starters: Orval Grove vs Red Ruffing | Sixth | 15 out |
| » Lost to Yankees (72-65), 9-8 | Yankee Stadium (2-7) | 67-74 | Lost 2 |
| » Starters: Ed Lopat vs Bill Bevens | Sixth | 15 out |
| Thursday, September 13 |
| » Defeated Yankees (72-66), 7-0 | Yankee Stadium (3-7) | 68-74 | |
| » Starters: Bill Dietrich vs Bill Zuber | Sixth | 14 out |
| Sunday, September 16 |
| » Defeated Red Sox (66-77), 5-3 | Fenway Park (4-4) | 69-74 | Won 2 |
| » Starters: Thornton Lee vs Mike Ryba | Sixth | 14½ out |
| » Defeated Red Sox (66-78), 6-1 | Fenway Park (5-4) | 70-74 | Won 3 |
| » Starters: Orval Grove vs Dave Ferriss | Sixth | 14½ out |
| Monday, September 17 |
| » Lost to Red Sox (67-78), 8-4 | Fenway Park (5-5) | 70-75 | |
| » Starters: Johnny Humphries vs Pinky Woods | Sixth | 14½ out |
| » Defeated Red Sox (67-79), 4-2 | Fenway Park (6-5) | 71-75 | |
| » Starters: Frank Papish vs Emmett O'Neill | Sixth | 14½ out |
| Saturday, September 22 |
| » Lost to Indians (71-70), 2-1 | League Park II (2-2) | 71-76 | |
| » Starters: Thornton Lee vs Steve Gromek | Sixth | 14 out |
| Sunday, September 23 |
| » Lost to Indians (72-70), 8-2 | Cleveland Stadium (3-4) | 71-77 | Lost 2 |
| » Starters: Orval Grove vs Bob Feller | Sixth | 14 out |
| Tuesday, September 25 |
| » Lost to Browns (80-69), 5-1 | Sportsman's Park III (2-8) | 71-78 | Lost 3 |
| » Starters: Ed Lopat vs Al Hollingsworth | Sixth | 14½ out |
| Wednesday, October 17 |
| Future White Sox Bob Christian is born in Chicago, IL. |
| Sunday, November 18 |
| Former White Sox Morrie Rath dies in Upper Darby, PA at the age of 59. |
| Tuesday, November 20 |
| Future White Sox Jay Johnstone is born in Manchester, CT. |
| Sunday, November 25 |
| Former White Sox Ham Patterson dies in E.St.Louis, IL at the age of 69. |
| Monday, December 3 |
| Future White Sox Steve Huntz is born in Cleveland, OH. |
| Wednesday, December 12 |
| Future White Sox Ralph Garr is born in Monroe, LA. |
| Wednesday, December 19 |
| Future White Sox Art Kusnyer is born in Akron, OH. |
| Wednesday, December 26 |
| Former White Sox Frank Lange dies in Madison, WI at the age of 63. |
Game information provided by Retrosheet (www.retrosheet.org) |
