| Monday, March 12 |
| Future Senator Horacio Pina is born in Coahuila, Mexico. |
| Tuesday, April 17 |
| » Defeated Athletics (0-1), 14-8 | Shibe Park (1-0) | 1-0 | |
| » Starters: Dutch Leonard vs Bobo Newsom | First | -- |
| Wednesday, April 18 |
| » Lost to Athletics (1-1), 1-0 | Shibe Park (1-1) | 1-1 | |
| » Starters: Johnny Niggeling vs Russ Christopher | Third | 1 out |
| Thursday, April 19 |
| » Defeated Athletics (1-2), 4-3 | Shibe Park (2-1) | 2-1 | |
| » Starters: Marino Pieretti vs Jesse Flores | Third | 1 out |
| » Major-league debuts: Marino Pieretti (Senators) |
| Friday, April 20 |
| » Lost to Yankees (4-0), 6-3 | Griffith Stadium (0-1) | 2-2 | |
| » Starters: Bill Bevens vs Mickey Haefner | Third | 2 out |
| » Major-league debuts: Al Gettel (Yankees) |
| Saturday, April 21 |
| » Defeated Yankees (4-1), 2-1 | Griffith Stadium (1-1) | 3-2 | |
| » Starters: Tiny Bonham vs Roger Wolff | Third | 1 out |
| Sunday, April 22 |
| » Lost to Yankees (5-1), 5-2 | Griffith Stadium (1-2) | 3-3 | |
| » Starters: Hank Borowy vs Dutch Leonard | Fourth | 2½ out |
| Thursday, April 26 |
| » Defeated Red Sox (0-7), 4-1 | Griffith Stadium (2-2) | 4-3 | |
| » Starters: Clem Dreisewerd vs Johnny Niggeling | Fourth | 2 out |
| Friday, April 27 |
| » Defeated Yankees (5-3), 6-4 | Yankee Stadium (1-0) | 5-3 | Won 2 |
| » Starters: Mickey Haefner vs Bill Bevens | Fourth | 1½ out |
| » Major-league debuts: Ken Holcombe (Yankees) |
| Saturday, April 28 |
| » Lost to Yankees (6-3), 2-1 | Yankee Stadium (1-1) | 5-4 | |
| » Starters: Marino Pieretti vs Tiny Bonham | Fourth | 2 out |
| Sunday, April 29 |
| » Lost to Yankees (7-3), 13-4 | Yankee Stadium (1-2) | 5-5 | Lost 2 |
| » Starters: Dutch Leonard vs Hank Borowy | Fourth | 2 out |
| » Defeated Yankees (7-4), 2-1 | Yankee Stadium (2-2) | 6-5 | |
| » Starters: Roger Wolff vs Atley Donald | Fourth | 2 out |
| Tuesday, May 1 |
| » Lost to Red Sox (4-8), 5-4 | Fenway Park (0-1) | 6-6 | |
| » Starters: Johnny Niggeling vs Emmett O'Neill | Fifth | 2 out |
| Wednesday, May 2 |
| » Lost to Red Sox (5-8), 4-0 | Fenway Park (0-2) | 6-7 | Lost 2 |
| » Starters: Mickey Haefner vs Jim Wilson | Fifth | 2½ out |
| Friday, May 4 |
| » Defeated Athletics (6-7), 5-4 | Griffith Stadium (3-2) | 7-7 | |
| » Starters: Jesse Flores vs Marino Pieretti | Fourth | 2 out |
| Saturday, May 5 |
| » Defeated Athletics (6-8), 7-3 | Griffith Stadium (4-2) | 8-7 | Won 2 |
| » Starters: Bobo Newsom vs Roger Wolff | Fourth | 2½ out |
| Sunday, May 6 |
| » Lost to Athletics (7-8), 3-2 | Griffith Stadium (4-3) | 8-8 | |
| » Starters: Russ Christopher vs Mickey Haefner | Fourth | 2½ out |
| » Defeated Athletics (7-9), 2-0 | Griffith Stadium (5-3) | 9-8 | |
| » Starters: Charlie Gassaway vs Dutch Leonard | Fourth | 2½ out |
| Tuesday, May 8 |
| » Lost to Browns (6-8), 7-1 | Sportsman's Park III (0-1) | 9-9 | |
| » Starters: Johnny Niggeling vs Nels Potter | Fourth | 2½ out |
| Thursday, May 10 |
| » Lost to Browns (7-8), 10-2 | Sportsman's Park III (0-2) | 9-10 | Lost 2 |
| » Starters: Marino Pieretti vs Jack Kramer | Fourth | 3½ out |
| Friday, May 11 |
| » Tied Browns, 1-1 | Sportsman's Park III (0-2) | 9-10 | |
| » Starters: Roger Wolff vs Tex Shirley | Fourth | 3 out |
| Saturday, May 12 |
| » Defeated White Sox (10-6), 3-0 | Comiskey Park I (1-0) | 10-10 | |
| » Starters: Dutch Leonard vs Joe Haynes | Fourth | 3 out |
| Sunday, May 13 |
| » Lost to White Sox (11-6), 5-1 | Comiskey Park I (1-1) | 10-11 | |
| » Starters: Mickey Haefner vs Thornton Lee | Fifth | 4 out |
| » Lost to White Sox (12-6), 4-2 | Comiskey Park I (1-2) | 10-12 | Lost 2 |
| » Starters: Alex Carrasquel vs Orval Grove | Fifth | 4 out |
| Thursday, May 17 |
| » Major-league debuts: Cy Buker (Dodgers) |
| Saturday, May 19 |
| » Defeated Tigers (11-8), 6-2 | Tiger Stadium (1-0) | 11-12 | |
| » Starters: Roger Wolff vs Dizzy Trout | Fifth | 4 out |
| » Lost to Tigers (12-8), 3-0 | Tiger Stadium (1-1) | 11-13 | |
| » Starters: Mickey Haefner vs Hal Newhouser | Fifth | 4 out |
| Sunday, May 20 |
| » Lost to Tigers (13-8), 4-1 | Tiger Stadium (1-2) | 11-14 | Lost 2 |
| » Starters: Johnny Niggeling vs Stubby Overmire | Fourth | 5 out |
| » Defeated Tigers (13-9), 1-0 | Tiger Stadium (2-2) | 12-14 | |
| » Starters: Marino Pieretti vs Al Benton | Fourth | 5 out |
| Wednesday, May 23 |
| » Lost to Indians (10-14), 3-2 | Griffith Stadium (5-4) | 12-15 | |
| » Starters: Allie Reynolds vs Dutch Leonard | Fifth | 5 out |
| Thursday, May 24 |
| » Lost to Indians (11-14), 1-0 | Griffith Stadium (5-5) | 12-16 | Lost 2 |
| » Starters: Steve Gromek vs Roger Wolff | Sixth | 5 out |
| Friday, May 25 |
| » Lost to Indians (12-14), 3-0 | Griffith Stadium (5-6) | 12-17 | Lost 3 |
| » Starters: Al Smith vs Marino Pieretti | Fifth | 5½ out |
| Sunday, May 27 |
| » Lost to Tigers (17-10), 3-1 | Griffith Stadium (5-7) | 12-18 | Lost 4 |
| » Starters: Hal Newhouser vs Johnny Niggeling | Sixth | 7 out |
| » Defeated Tigers (17-11), 2-1 | Griffith Stadium (6-7) | 13-18 | |
| » Starters: Joe Orrell vs Mickey Haefner | Sixth | 7 out |
| Wednesday, May 30 |
| » Defeated Browns (15-15), 3-2 | Griffith Stadium (7-7) | 14-18 | Won 2 |
| » Starters: Tex Shirley vs Dutch Leonard | Sixth | 6½ out |
| » Defeated Browns (15-16), 5-0 | Griffith Stadium (8-7) | 15-18 | Won 3 |
| » Starters: Nels Potter vs Marino Pieretti | Sixth | 6½ out |
| Thursday, May 31 |
| » Lost to Browns (16-16), 5-2 | Griffith Stadium (8-8) | 15-19 | |
| » Starters: Al Hollingsworth vs Mickey Haefner | Seventh | 6½ out |
| Friday, June 1 |
| » Lost to White Sox (18-16), 11-9 | Griffith Stadium (8-9) | 15-20 | Lost 2 |
| » Starters: Joe Haynes vs Johnny Niggeling | Seventh | 7½ out |
| Saturday, June 2 |
| » Defeated White Sox (18-17), 8-1 | Griffith Stadium (9-9) | 16-20 | |
| » Starters: Orval Grove vs Dutch Leonard | Seventh | 6½ out |
| Sunday, June 3 |
| » Defeated White Sox (18-18), 3-1 | Griffith Stadium (10-9) | 17-20 | Won 2 |
| » Starters: Thornton Lee vs Roger Wolff | Seventh | 6½ out |
| » Lost to White Sox (19-18), 5-1 | Griffith Stadium (10-10) | 17-21 | |
| » Starters: Johnny Humphries vs Marino Pieretti | Seventh | 6½ out |
| Tuesday, June 5 |
| » Lost to Yankees (25-15), 12-3 | Griffith Stadium (10-11) | 17-22 | Lost 2 |
| » Starters: Atley Donald vs Mickey Haefner | Seventh | 6½ out |
| » Defeated Yankees (25-16), 7-3 | Griffith Stadium (11-11) | 18-22 | |
| » Starters: Bill Bevens vs Marino Pieretti | Seventh | 6½ out |
| Wednesday, June 6 |
| » Defeated Yankees (25-17), 4-0 | Griffith Stadium (12-11) | 19-22 | Won 2 |
| » Starters: Bill Zuber vs Dutch Leonard | Sixth | 5½ out |
| Friday, June 8 |
| » Lost to Athletics (16-26), 4-0 | Shibe Park (2-2) | 19-23 | |
| » Starters: Johnny Niggeling vs Russ Christopher | Seventh | 5½ out |
| Saturday, June 9 |
| » Defeated Athletics (16-27), 3-2 | Shibe Park (3-2) | 20-23 | |
| » Starters: Roger Wolff vs Bobo Newsom | Sixth | 5½ out |
| Tuesday, June 12 |
| » Defeated Yankees (27-19), 5-3 | Yankee Stadium (3-2) | 21-23 | Won 2 |
| » Starters: Dutch Leonard vs Monk Dubiel | Sixth | 5½ out |
| Friday, June 15 |
| » Lost to Red Sox (25-23), 6-5 | Griffith Stadium (12-12) | 21-24 | |
| » Starters: Dave Ferriss vs Marino Pieretti | Sixth | 6 out |
| » Tied Red Sox, 4-4 | Griffith Stadium (12-12) | 21-24 | |
| » Starters: Mike Ryba vs Johnny Niggeling | Sixth | 6 out |
| Saturday, June 16 |
| » Defeated Red Sox (25-24), 4-0 | Griffith Stadium (13-12) | 22-24 | |
| » Starters: Yank Terry vs Mickey Haefner | Sixth | 6½ out |
| Sunday, June 17 |
| » Lost to Red Sox (26-24), 2-1 | Griffith Stadium (13-13) | 22-25 | |
| » Starters: Emmett O'Neill vs Dutch Leonard | Sixth | 6½ out |
| » Lost to Red Sox (27-24), 7-1 | Griffith Stadium (13-14) | 22-26 | Lost 2 |
| » Starters: Jim Wilson vs Sandy Ullrich | Sixth | 6½ out |
| Tuesday, June 19 |
| » Defeated Athletics (20-30), 6-0 | Griffith Stadium (14-14) | 23-26 | |
| » Starters: Lou Knerr vs Roger Wolff | Sixth | 5½ out |
| » Defeated Athletics (20-31), 5-3 | Griffith Stadium (15-14) | 24-26 | Won 2 |
| » Starters: Jesse Flores vs Marino Pieretti | Sixth | 5½ out |
| Wednesday, June 20 |
| » Defeated Athletics (20-32), 7-5 | Griffith Stadium (16-14) | 25-26 | Won 3 |
| » Starters: Bobo Newsom vs Mickey Haefner | Fifth | 5½ out |
| Friday, June 22 |
| » Lost to Red Sox (29-25), 10-5 | Fenway Park (0-3) | 25-27 | |
| » Starters: Johnny Niggeling vs Emmett O'Neill | Sixth | 6 out |
| Saturday, June 23 |
| » Defeated Red Sox (29-26), 6-5 | Fenway Park (1-3) | 26-27 | |
| » Starters: Roger Wolff vs Jim Wilson | Fifth | 6 out |
| Sunday, June 24 |
| » Lost to Red Sox (30-26), 6-5 | Fenway Park (1-4) | 26-28 | |
| » Starters: Mickey Haefner vs Dave Ferriss | Fifth | 7 out |
| » Defeated Red Sox (30-27), 5-2 | Fenway Park (2-4) | 27-28 | |
| » Starters: Marino Pieretti vs Clem Hausmann | Fifth | 7 out |
| Wednesday, June 27 |
| » Defeated Tigers (35-23), 9-1 | Tiger Stadium (3-2) | 28-28 | Won 2 |
| » Starters: Dutch Leonard vs Dizzy Trout | Fourth | 6 out |
| Thursday, June 28 |
| » Lost to Tigers (36-23), 5-2 | Tiger Stadium (3-3) | 28-29 | |
| » Starters: Roger Wolff vs Hal Newhouser | Fifth | 7 out |
| Friday, June 29 |
| » Defeated Tigers (36-24), 8-3 | Tiger Stadium (4-3) | 29-29 | |
| » Starters: Marino Pieretti vs Stubby Overmire | Fifth | 6 out |
| Saturday, June 30 |
| » Defeated Indians (26-32), 3-0 | Cleveland Stadium (1-0) | 30-29 | Won 2 |
| » Starters: Johnny Niggeling vs Steve Gromek | Fourth | 5½ out |
| » Defeated Indians (26-33), 7-1 | Cleveland Stadium (2-0) | 31-29 | Won 3 |
| » Starters: Mickey Haefner vs Ed Klieman | Fourth | 5½ out |
| Sunday, July 1 |
| » Defeated Indians (26-34), 6-5 | Cleveland Stadium (3-0) | 32-29 | Won 4 |
| » Starters: Dutch Leonard vs Mel Harder | Fifth | 6½ out |
| » Lost to Indians (27-34), 6-5 | Cleveland Stadium (3-1) | 32-30 | |
| » Starters: Sandy Ullrich vs Pete Center | Fifth | 6½ out |
| Tuesday, July 3 |
| » Defeated White Sox (35-32), 12-2 | Comiskey Park I (2-2) | 33-30 | |
| » Starters: Roger Wolff vs Earl Caldwell | Fourth | 5½ out |
| Wednesday, July 4 |
| » Defeated White Sox (35-33), 5-4 | Comiskey Park I (3-2) | 34-30 | Won 2 |
| » Starters: Marino Pieretti vs Orval Grove | Third | 4½ out |
| » Defeated White Sox (35-34), 11-2 | Comiskey Park I (4-2) | 35-30 | Won 3 |
| » Starters: Mickey Haefner vs Johnny Humphries | Third | 4½ out |
| Thursday, July 5 |
| » Defeated White Sox (35-35), 5-2 | Comiskey Park I (5-2) | 36-30 | Won 4 |
| » Starters: Dutch Leonard vs Ed Lopat | Second | 4½ out |
| Friday, July 6 |
| » Defeated Browns (32-34), 6-3 | Sportsman's Park III (1-2) | 37-30 | Won 5 |
| » Starters: Johnny Niggeling vs Tex Shirley | Second | 3 out |
| » Defeated Browns (32-35), 5-2 | Sportsman's Park III (2-2) | 38-30 | Won 6 |
| » Starters: Sandy Ullrich vs Jack Kramer | Second | 3 out |
| Saturday, July 7 |
| » Lost to Browns (33-35), 7-3 | Sportsman's Park III (2-3) | 38-31 | |
| » Starters: Roger Wolff vs Sig Jakucki | Second | 4 out |
| Sunday, July 8 |
| » Lost to Browns (34-35), 5-1 | Sportsman's Park III (2-4) | 38-32 | Lost 2 |
| » Starters: Marino Pieretti vs Nels Potter | Second | 4½ out |
| Thursday, July 12 |
| » Defeated White Sox (39-37), 4-2 | Griffith Stadium (17-14) | 39-32 | |
| » Starters: Thornton Lee vs Dutch Leonard | Second | 3½ out |
| Friday, July 13 |
| » Defeated White Sox (39-38), 3-2 | Griffith Stadium (18-14) | 40-32 | Won 2 |
| » Starters: Ed Lopat vs Mickey Haefner | Second | 2½ out |
| Monday, July 16 |
| » Lost to Browns (36-38), 7-3 | Griffith Stadium (18-15) | 40-33 | |
| » Starters: Al Hollingsworth vs Johnny Niggeling | Second | 3 out |
| » Lost to Browns (37-38), 5-1 | Griffith Stadium (18-16) | 40-34 | Lost 2 |
| » Starters: Tex Shirley vs Roger Wolff | Second | 3 out |
| Wednesday, July 18 |
| » Lost to Tigers (45-32), 6-4 | Griffith Stadium (18-17) | 40-35 | Lost 3 |
| » Starters: Hal Newhouser vs Mickey Haefner | Fourth | 5 out |
| » Lost to Tigers (46-32), 5-0 | Griffith Stadium (18-18) | 40-36 | Lost 4 |
| » Starters: Al Benton vs Marino Pieretti | Fourth | 5 out |
| Friday, July 20 |
| » Defeated Tigers (46-33), 4-3 | Griffith Stadium (19-18) | 41-36 | |
| » Starters: Stubby Overmire vs Dutch Leonard | Second | 3 out |
| » Defeated Tigers (46-34), 3-1 | Griffith Stadium (20-18) | 42-36 | Won 2 |
| » Starters: Zeb Eaton vs Roger Wolff | Second | 3 out |
| Saturday, July 21 |
| » Defeated Indians (37-42), 7-4 | Griffith Stadium (21-18) | 43-36 | Won 3 |
| » Starters: Al Smith vs Johnny Niggeling | Second | 2½ out |
| Sunday, July 22 |
| » Defeated Indians (37-43), 5-4 | Griffith Stadium (22-18) | 44-36 | Won 4 |
| » Starters: Steve Gromek vs Mickey Haefner | Second | 2½ out |
| » Lost to Indians (38-43), 9-3 | Griffith Stadium (22-19) | 44-37 | |
| » Starters: Jim Bagby vs Marino Pieretti | Second | 2½ out |
| Monday, July 23 |
| » Lost to Indians (39-43), 2-1 | Griffith Stadium (22-20) | 44-38 | Lost 2 |
| » Starters: Ed Klieman vs Johnny Niggeling | Second | 2½ out |
| Tuesday, July 24 |
| » Lost to Indians (40-43), 4-0 | Griffith Stadium (22-21) | 44-39 | Lost 3 |
| » Starters: Allie Reynolds vs Dutch Leonard | Second | 3 out |
| Friday, July 27 |
| » Defeated Red Sox (44-42), 3-1 | Fenway Park (3-4) | 45-39 | |
| » Starters: Roger Wolff vs Dave Ferriss | Second | 3 out |
| Saturday, July 28 |
| » Lost to Red Sox (45-42), 6-2 | Fenway Park (3-5) | 45-40 | |
| » Starters: Marino Pieretti vs Jim Wilson | Second | 4 out |
| Sunday, July 29 |
| » Lost to Red Sox (46-42), 8-4 | Fenway Park (3-6) | 45-41 | Lost 2 |
| » Starters: Johnny Niggeling vs Emmett O'Neill | Fourth | 5 out |
| Wednesday, August 1 |
| » Defeated Athletics (30-57), 2-1 | Griffith Stadium (23-21) | 46-41 | |
| » Starters: Jesse Flores vs Dutch Leonard | Second | 5 out |
| » Defeated Athletics (30-58), 3-0 | Griffith Stadium (24-21) | 47-41 | Won 2 |
| » Starters: Bobo Newsom vs Roger Wolff | Second | 5 out |
| Thursday, August 2 |
| » Defeated Athletics (30-59), 2-1 | Griffith Stadium (25-21) | 48-41 | Won 3 |
| » Starters: Lou Knerr vs Mickey Haefner | Second | 4½ out |
| » Defeated Athletics (30-60), 2-1 | Griffith Stadium (26-21) | 49-41 | Won 4 |
| » Starters: Steve Gerkin vs Marino Pieretti | Second | 4½ out |
| Friday, August 3 |
| » Defeated Red Sox (47-45), 7-3 | Griffith Stadium (27-21) | 50-41 | Won 5 |
| » Starters: Emmett O'Neill vs Alex Carrasquel | Second | 3 out |
| » Defeated Red Sox (47-46), 3-1 | Griffith Stadium (28-21) | 51-41 | Won 6 |
| » Starters: Jim Wilson vs Johnny Niggeling | Second | 3 out |
| Saturday, August 4 |
| » Defeated Red Sox (47-47), 4-0 | Griffith Stadium (29-21) | 52-41 | Won 7 |
| » Starters: Vic Johnson vs Wally Holborow | Second | 2½ out |
| » Lost to Red Sox (48-47), 15-4 | Griffith Stadium (29-22) | 52-42 | |
| » Starters: Dave Ferriss vs Sandy Ullrich | Second | 2½ out |
| » Major-league debuts: Joe Cleary and Bert Shepard (Senators) |
| Sunday, August 5 |
| » Defeated Red Sox (48-48), 5-4 | Griffith Stadium (30-22) | 53-42 | |
| » Starters: Pinky Woods vs Dutch Leonard | Second | 1½ out |
| » Defeated Red Sox (48-49), 5-1 | Griffith Stadium (31-22) | 54-42 | Won 2 |
| » Starters: Clem Hausmann vs Roger Wolff | Second | 1½ out |
| Tuesday, August 7 |
| Former Senator Bobby Veach dies in Detroit, MI at the age of 58. |
| Wednesday, August 8 |
| » Lost to White Sox (51-47), 7-3 | Comiskey Park I (5-3) | 54-43 | |
| » Starters: Marino Pieretti vs Earl Caldwell | Second | 1 out |
| Thursday, August 9 |
| » Defeated White Sox (51-48), 7-2 | Comiskey Park I (6-3) | 55-43 | |
| » Starters: Mickey Haefner vs Bill Dietrich | Second | 1 out |
| Friday, August 10 |
| » Lost to White Sox (52-48), 6-3 | Comiskey Park I (6-4) | 55-44 | |
| » Starters: Roger Wolff vs Thornton Lee | Second | 1 out |
| Saturday, August 11 |
| » Defeated White Sox (52-49), 11-2 | Comiskey Park I (7-4) | 56-44 | |
| » Starters: Dutch Leonard vs Orval Grove | Second | 1 out |
| Sunday, August 12 |
| » Defeated Browns (48-51), 9-5 | Sportsman's Park III (3-4) | 57-44 | Won 2 |
| » Starters: Johnny Niggeling vs Tex Shirley | Second | 2 out |
| » Lost to Browns (49-51), 4-1 | Sportsman's Park III (3-5) | 57-45 | |
| » Starters: Marino Pieretti vs Bob Muncrief | Second | 2 out |
| Monday, August 13 |
| » Lost to Browns (50-51), 4-2 | Sportsman's Park III (3-6) | 57-46 | Lost 2 |
| » Starters: Mickey Haefner vs Al Hollingsworth | Second | 3 out |
| » Defeated Browns (50-52), 11-3 | Sportsman's Park III (4-6) | 58-46 | |
| » Starters: Alex Carrasquel vs Sig Jakucki | Second | 3 out |
| Tuesday, August 14 |
| » Lost to Browns (51-52), 5-4 | Sportsman's Park III (4-7) | 58-47 | |
| » Starters: Roger Wolff vs Nels Potter | Second | 3½ out |
| Wednesday, August 15 |
| » Defeated Tigers (61-44), 8-0 | Tiger Stadium (5-3) | 59-47 | |
| » Starters: Dutch Leonard vs Jim Tobin | Second | 2½ out |
| Thursday, August 16 |
| » Lost to Tigers (62-44), 9-2 | Tiger Stadium (5-4) | 59-48 | |
| » Starters: Marino Pieretti vs Hal Newhouser | Second | 3½ out |
| Future Senator Jan Dukes is born in Cheyenne, WY. |
| Friday, August 17 |
| » Defeated Tigers (62-45), 3-1 | Tiger Stadium (6-4) | 60-48 | |
| » Starters: Mickey Haefner vs Stubby Overmire | Second | 2½ out |
| Saturday, August 18 |
| » Defeated Tigers (62-46), 11-5 | Tiger Stadium (7-4) | 61-48 | Won 2 |
| » Starters: Roger Wolff vs Al Benton | Second | 1½ out |
| Sunday, August 19 |
| » Defeated Indians (57-52), 7-1 | Cleveland Stadium (4-1) | 62-48 | Won 3 |
| » Starters: Johnny Niggeling vs Al Smith | Second | 1½ out |
| » Lost to Indians (58-52), 9-3 | Cleveland Stadium (4-2) | 62-49 | |
| » Starters: Dutch Leonard vs Allie Reynolds | Second | 1½ out |
| Monday, August 20 |
| » Defeated Indians (58-53), 7-0 | Cleveland Stadium (5-2) | 63-49 | |
| » Starters: Marino Pieretti vs Pete Center | Second | 1½ out |
| » Defeated Indians (58-54), 6-0 | Cleveland Stadium (6-2) | 64-49 | Won 2 |
| » Starters: Alex Carrasquel vs Steve Gromek | Second | 1½ out |
| » Major-league debuts: Dick Kimble (Senators) |
| Tuesday, August 21 |
| » Defeated Indians (58-55), 11-8 | League Park II (1-0) | 65-49 | Won 3 |
| » Starters: Mickey Haefner vs Ed Klieman | Second | 1 out |
| Wednesday, August 22 |
| » Defeated Indians (58-56), 3-0 | League Park II (2-0) | 66-49 | Won 4 |
| » Starters: Roger Wolff vs Mel Harder | Second | ½ out |
| » Defeated Indians (58-57), 6-5 | League Park II (3-0) | 67-49 | Won 5 |
| » Starters: Sandy Ullrich vs Steve Gromek | Second | ½ out |
| Saturday, August 25 |
| » Lost to Yankees (57-55), 4-2 | Yankee Stadium (3-3) | 67-50 | |
| » Starters: Dutch Leonard vs Bill Bevens | Second | 1½ out |
| » Lost to Yankees (58-55), 5-4 | Yankee Stadium (3-4) | 67-51 | Lost 2 |
| » Starters: Johnny Niggeling vs Tiny Bonham | Second | 1½ out |
| Sunday, August 26 |
| » Lost to Yankees (59-55), 3-2 | Yankee Stadium (3-5) | 67-52 | Lost 3 |
| » Starters: Mickey Haefner vs Red Ruffing | Second | 1½ out |
| » Lost to Yankees (60-55), 7-1 | Yankee Stadium (3-6) | 67-53 | Lost 4 |
| » Starters: Roger Wolff vs Al Gettel | Second | 1½ out |
| Tuesday, August 28 |
| » Defeated Athletics (36-80), 6-5 | Shibe Park (4-2) | 68-53 | |
| » Starters: Marino Pieretti vs Don Black | Second | 1½ out |
| Wednesday, August 29 |
| » Defeated Athletics (36-81), 3-2 | Shibe Park (5-2) | 69-53 | Won 2 |
| » Starters: Dutch Leonard vs Bobo Newsom | Second | 1 out |
| » Lost to Athletics (37-81), 2-1 | Shibe Park (5-3) | 69-54 | |
| » Starters: Roger Wolff vs Phil Marchildon | Second | 1 out |
| Friday, August 31 |
| » Lost to Yankees (63-56), 3-2 | Griffith Stadium (31-23) | 69-55 | Lost 2 |
| » Starters: Tiny Bonham vs Mickey Haefner | Second | 1½ out |
| » Lost to Yankees (64-56), 3-1 | Griffith Stadium (31-24) | 69-56 | Lost 3 |
| » Starters: Al Gettel vs Johnny Niggeling | Second | 1½ out |
| Saturday, September 1 |
| » Defeated Yankees (64-57), 3-0 | Griffith Stadium (32-24) | 70-56 | |
| » Starters: Red Ruffing vs Alex Carrasquel | Second | 1½ out |
| Sunday, September 2 |
| » Lost to Yankees (65-57), 4-2 | Griffith Stadium (32-25) | 70-57 | |
| » Starters: Joe Page vs Dutch Leonard | Second | 2 out |
| » Defeated Yankees (65-58), 3-0 | Griffith Stadium (33-25) | 71-57 | |
| » Starters: Bill Zuber vs Roger Wolff | Second | 2 out |
| Monday, September 3 |
| » Defeated Red Sox (60-69), 11-5 | Fenway Park (4-6) | 72-57 | Won 2 |
| » Starters: Marino Pieretti vs Dave Ferriss | Second | 2 out |
| » Lost to Red Sox (61-69), 8-4 | Fenway Park (4-7) | 72-58 | |
| » Starters: Sandy Ullrich vs Vic Johnson | Second | 2 out |
| Wednesday, September 5 |
| » Defeated Browns (69-59), 2-1 | Griffith Stadium (34-25) | 73-58 | |
| » Starters: Al Hollingsworth vs Mickey Haefner | Second | 2½ out |
| » Lost to Browns (70-59), 4-3 | Griffith Stadium (34-26) | 73-59 | |
| » Starters: Nels Potter vs Alex Carrasquel | Second | 2½ out |
| Thursday, September 6 |
| » Defeated Browns (70-60), 2-0 | Griffith Stadium (35-26) | 74-59 | |
| » Starters: Tex Shirley vs Johnny Niggeling | Second | 1½ out |
| » Defeated Browns (70-61), 3-2 | Griffith Stadium (36-26) | 75-59 | Won 2 |
| » Starters: Jack Kramer vs Dutch Leonard | Second | 1½ out |
| Friday, September 7 |
| » Defeated Browns (70-62), 3-2 | Griffith Stadium (37-26) | 76-59 | Won 3 |
| » Starters: Bob Muncrief vs Roger Wolff | Second | 1½ out |
| Saturday, September 8 |
| » Defeated Browns (70-63), 4-1 | Griffith Stadium (38-26) | 77-59 | Won 4 |
| » Starters: Lefty West vs Pete Appleton | Second | 1½ out |
| Sunday, September 9 |
| » Defeated White Sox (65-70), 4-2 | Griffith Stadium (39-26) | 78-59 | Won 5 |
| » Starters: Johnny Humphries vs Mickey Haefner | Second | 2 out |
| » Defeated White Sox (65-71), 5-4 | Griffith Stadium (40-26) | 79-59 | Won 6 |
| » Starters: Frank Papish vs Alex Carrasquel | Second | 2 out |
| Monday, September 10 |
| » Defeated White Sox (65-72), 10-4 | Griffith Stadium (41-26) | 80-59 | Won 7 |
| » Starters: Thornton Lee vs Dutch Leonard | Second | 2 out |
| » Lost to White Sox (66-72), 9-4 | Griffith Stadium (41-27) | 80-60 | |
| » Starters: Earl Caldwell vs Marino Pieretti | Second | 2 out |
| Tuesday, September 11 |
| » Lost to White Sox (67-72), 2-1 | Griffith Stadium (41-28) | 80-61 | Lost 2 |
| » Starters: Thornton Lee vs Johnny Niggeling | Second | 2 out |
| Wednesday, September 12 |
| » Defeated Indians (67-66), 5-1 | Griffith Stadium (42-28) | 81-61 | |
| » Starters: Steve Gromek vs Roger Wolff | Second | 1½ out |
| Thursday, September 13 |
| » Defeated Indians (67-67), 4-0 | Griffith Stadium (43-28) | 82-61 | Won 2 |
| » Starters: Bob Feller vs Walt Masterson | Second | 1½ out |
| Friday, September 14 |
| » Defeated Indians (67-68), 6-5 | Griffith Stadium (44-28) | 83-61 | Won 3 |
| » Starters: Allie Reynolds vs Pete Appleton | Second | 1½ out |
| Saturday, September 15 |
| » Lost to Tigers (83-59), 7-4 | Griffith Stadium (44-29) | 83-62 | |
| » Starters: Hal Newhouser vs Dutch Leonard | Second | 2½ out |
| » Lost to Tigers (84-59), 7-3 | Griffith Stadium (44-30) | 83-63 | Lost 2 |
| » Starters: Dizzy Trout vs Mickey Haefner | Second | 2½ out |
| Sunday, September 16 |
| » Defeated Tigers (84-60), 3-2 | Griffith Stadium (45-30) | 84-63 | |
| » Starters: Hal Newhouser vs Roger Wolff | Second | 2½ out |
| » Lost to Tigers (85-60), 5-4 | Griffith Stadium (45-31) | 84-64 | |
| » Starters: Al Benton vs Johnny Niggeling | Second | 2½ out |
| Tuesday, September 18 |
| » Defeated Tigers (85-61), 12-5 | Griffith Stadium (46-31) | 85-64 | |
| » Starters: Dizzy Trout vs Walt Masterson | Second | 1½ out |
| Thursday, September 20 |
| » Lost to Yankees (75-70), 6-1 | Yankee Stadium (3-7) | 85-65 | |
| » Starters: Mickey Haefner vs Joe Page | Second | 1 out |
| Friday, September 21 |
| » Lost to Yankees (76-70), 5-3 | Yankee Stadium (3-8) | 85-66 | Lost 2 |
| » Starters: Johnny Niggeling vs Bill Zuber | Second | 1½ out |
| Saturday, September 22 |
| » Defeated Athletics (51-96), 2-0 | Shibe Park (6-3) | 86-66 | |
| » Starters: Roger Wolff vs Russ Christopher | Second | 1½ out |
| Sunday, September 23 |
| » Lost to Athletics (52-96), 4-3 | Shibe Park (6-4) | 86-67 | |
| » Starters: Dutch Leonard vs Bobo Newsom | Second | 2 out |
| » Defeated Athletics (52-97), 4-3 | Shibe Park (7-4) | 87-67 | |
| » Starters: Marino Pieretti vs Dick Fowler | Second | 2 out |
| Tuesday, October 9 |
| Former Senator Bob Ganley dies in Lowell, MA at the age of 71. |
| Thursday, November 22 |
| Future Senator Denny Riddleberger is born in Clifton Forge, VA. |
| Friday, December 14 |
| Future Senator Greg Goossen is born in Los Angeles, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |
