| Monday, March 12 |
| Future Indian Horacio Pina is born in Coahuila, Mexico. |
| Monday, April 2 |
| Future Indian Mike Kekich is born in San Diego, CA. |
| Monday, April 16 |
| Former Indian Chick Fewster dies in Baltimore, MD at the age of 50. |
| Tuesday, April 17 |
| » Lost to White Sox (1-0), 5-2 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Thornton Lee vs Allie Reynolds | Second | 1 out |
| Wednesday, April 18 |
| » Major-league debuts: Ken Gables and Bill Salkeld (Pirates) |
| Future Indian Mike Paul is born in Detroit, MI. |
| Thursday, April 19 |
| » Lost to White Sox (2-0), 14-6 | League Park II (0-1) | 0-2 | Lost 2 |
| » Starters: Bill Dietrich vs Jim Bagby | Fifth | 2½ out |
| Future Indian Tommy Gramly is born in Dallas, TX. |
| Friday, April 20 |
| » Defeated Tigers (2-2), 4-1 | Tiger Stadium (1-0) | 1-2 | |
| » Starters: Steve Gromek vs Stubby Overmire | Fourth | 2½ out |
| Saturday, April 21 |
| » Lost to Tigers (3-2), 3-2 | Tiger Stadium (1-1) | 1-3 | |
| » Starters: Red Embree vs Hal Newhouser | Fourth | 2½ out |
| Sunday, April 22 |
| » Lost to Tigers (4-2), 6-3 | Tiger Stadium (1-2) | 1-4 | Lost 2 |
| » Starters: Allie Reynolds vs Dizzy Trout | Fifth | 4 out |
| Thursday, April 26 |
| » Lost to Browns (2-5), 4-3 | League Park II (0-2) | 1-5 | Lost 3 |
| » Starters: Nels Potter vs Al Smith | Sixth | 4½ out |
| Saturday, April 28 |
| » Lost to Tigers (5-2), 5-1 | League Park II (0-3) | 1-6 | Lost 4 |
| » Starters: Al Benton vs Jim Bagby | Sixth | 5 out |
| Sunday, April 29 |
| » Defeated Tigers (5-3), 4-0 | Cleveland Stadium (1-1) | 2-6 | |
| » Starters: Hal Newhouser vs Steve Gromek | Seventh | 4 out |
| » Lost to Tigers (6-3), 4-0 | Cleveland Stadium (1-2) | 2-7 | |
| » Starters: Dizzy Trout vs Red Embree | Seventh | 4 out |
| » Major-league debuts: Art Houtteman (Tigers) |
| Wednesday, May 2 |
| » Defeated Browns (4-6), 2-1 | Sportsman's Park III (1-0) | 3-7 | |
| » Starters: Allie Reynolds vs Nels Potter | Eighth | 4 out |
| Saturday, May 5 |
| » Lost to White Sox (7-3), 3-2 | Comiskey Park I (0-1) | 3-8 | |
| » Starters: Al Smith vs Thornton Lee | Eighth | 4½ out |
| Sunday, May 6 |
| » Lost to White Sox (8-3), 3-2 | Comiskey Park I (0-2) | 3-9 | Lost 2 |
| » Starters: Jim Bagby vs Ed Lopat | Eighth | 6½ out |
| » Lost to White Sox (9-3), 6-4 | Comiskey Park I (0-3) | 3-10 | Lost 3 |
| » Starters: Steve Gromek vs Joe Haynes | Eighth | 6½ out |
| Tuesday, May 8 |
| » Defeated White Sox (9-4), 7-1 | Comiskey Park I (1-3) | 4-10 | |
| » Starters: Red Embree vs Orval Grove | Eighth | 5½ out |
| » Major-league debuts: Frank Papish (White Sox) |
| Wednesday, May 9 |
| » Defeated Red Sox (6-11), 2-1 | League Park II (1-3) | 5-10 | Won 2 |
| » Starters: Jim Wilson vs Allie Reynolds | Eighth | 5½ out |
| Friday, May 11 |
| » Lost to Red Sox (7-11), 8-4 | League Park II (1-4) | 5-11 | |
| » Starters: Rex Cecil vs Al Smith | Eighth | 5½ out |
| » Major-league debuts: Red Steiner (Indians) |
| Saturday, May 12 |
| » Lost to Yankees (12-6), 7-3 | League Park II (1-5) | 5-12 | Lost 2 |
| » Starters: Monk Dubiel vs Jim Bagby | Seventh | 6½ out |
| Sunday, May 13 |
| » Lost to Yankees (13-6), 1-0 | Cleveland Stadium (1-3) | 5-13 | Lost 3 |
| » Starters: Atley Donald vs Red Embree | Eighth | 6½ out |
| » Defeated Yankees (13-7), 4-2 | Cleveland Stadium (2-3) | 6-13 | |
| » Starters: Tiny Bonham vs Steve Gromek | Eighth | 6½ out |
| Thursday, May 17 |
| » Major-league debuts: Cy Buker (Dodgers) |
| Saturday, May 19 |
| » Defeated Athletics (9-13), 4-0 | League Park II (2-5) | 7-13 | Won 2 |
| » Starters: Russ Christopher vs Allie Reynolds | Eighth | 5½ out |
| » Defeated Athletics (9-14), 2-1 | League Park II (3-5) | 8-13 | Won 3 |
| » Starters: Don Black vs Steve Gromek | Eighth | 5½ out |
| Sunday, May 20 |
| » Lost to Athletics (10-14), 6-2 | Cleveland Stadium (2-4) | 8-14 | |
| » Starters: Charlie Gassaway vs Jim Bagby | Sixth | 6½ out |
| » Defeated Athletics (10-15), 4-2 | Cleveland Stadium (3-4) | 9-14 | |
| » Starters: Lou Knerr vs Red Embree | Sixth | 6½ out |
| Wednesday, May 23 |
| » Defeated Senators (12-15), 3-2 | Griffith Stadium (1-0) | 10-14 | Won 2 |
| » Starters: Allie Reynolds vs Dutch Leonard | Sixth | 5½ out |
| Thursday, May 24 |
| » Defeated Senators (12-16), 1-0 | Griffith Stadium (2-0) | 11-14 | Won 3 |
| » Starters: Steve Gromek vs Roger Wolff | Fifth | 4½ out |
| Friday, May 25 |
| » Defeated Senators (12-17), 3-0 | Griffith Stadium (3-0) | 12-14 | Won 4 |
| » Starters: Al Smith vs Marino Pieretti | Fourth | 4 out |
| Sunday, May 27 |
| » Defeated Athletics (11-20), 8-3 | Shibe Park (1-0) | 13-14 | Won 5 |
| » Starters: Red Embree vs Charlie Gassaway | Fourth | 5 out |
| Tuesday, May 29 |
| » Lost to Athletics (12-20), 2-1 | Shibe Park (1-1) | 13-15 | |
| » Starters: Allie Reynolds vs Jesse Flores | Fifth | 6 out |
| Future Indian Blue Moon Odom is born in Macon, GA. |
| Wednesday, May 30 |
| » Defeated Red Sox (14-19), 4-3 | Fenway Park (1-0) | 14-15 | |
| » Starters: Steve Gromek vs Jim Wilson | Fifth | 6 out |
| » Lost to Red Sox (15-19), 7-6 | Fenway Park (1-1) | 14-16 | |
| » Starters: Jim Bagby vs Yank Terry | Fifth | 6 out |
| Thursday, May 31 |
| » Lost to Red Sox (16-19), 6-2 | Fenway Park (1-2) | 14-17 | Lost 2 |
| » Starters: Red Embree vs Dave Ferriss | Sixth | 6 out |
| Friday, June 1 |
| » Lost to Yankees (23-13), 9-2 | Yankee Stadium (0-1) | 14-18 | Lost 3 |
| » Starters: Al Smith vs Bill Bevens | Sixth | 7 out |
| Saturday, June 2 |
| » Defeated Yankees (23-14), 4-0 | Yankee Stadium (1-1) | 15-18 | |
| » Starters: Ed Klieman vs Tiny Bonham | Sixth | 6 out |
| Sunday, June 3 |
| » Lost to Yankees (24-14), 8-2 | Yankee Stadium (1-2) | 15-19 | |
| » Starters: Allie Reynolds vs Hank Borowy | Sixth | 6 out |
| » Defeated Yankees (24-15), 4-1 | Yankee Stadium (2-2) | 16-19 | |
| » Starters: Steve Gromek vs Monk Dubiel | Sixth | 6 out |
| Tuesday, June 5 |
| » Defeated Tigers (20-16), 9-0 | Cleveland Stadium (4-4) | 17-19 | Won 2 |
| » Starters: Les Mueller vs Red Embree | Sixth | 5½ out |
| Wednesday, June 6 |
| » Lost to Tigers (21-16), 8-1 | League Park II (3-6) | 17-20 | |
| » Starters: Stubby Overmire vs Al Smith | Seventh | 5½ out |
| Thursday, June 7 |
| » Lost to Tigers (22-16), 3-2 | League Park II (3-7) | 17-21 | Lost 2 |
| » Starters: Hal Newhouser vs Allie Reynolds | Seventh | 6 out |
| Friday, June 8 |
| » Defeated Browns (21-19), 2-1 | Cleveland Stadium (5-4) | 18-21 | |
| » Starters: Nels Potter vs Steve Gromek | Sixth | 5 out |
| Saturday, June 9 |
| » Defeated Browns (21-20), 2-1 | League Park II (4-7) | 19-21 | Won 2 |
| » Starters: Al Hollingsworth vs Ed Klieman | Fifth | 5 out |
| Sunday, June 10 |
| » Defeated Browns (21-21), 2-1 | Cleveland Stadium (6-4) | 20-21 | Won 3 |
| » Starters: Sig Jakucki vs Jim Bagby | Fifth | 5½ out |
| » Lost to Browns (22-21), 4-1 | Cleveland Stadium (6-5) | 20-22 | |
| » Starters: Lefty West vs Allie Reynolds | Fifth | 5½ out |
| Tuesday, June 12 |
| » Lost to White Sox (22-24), 1-0 | Comiskey Park I (1-4) | 20-23 | Lost 2 |
| » Starters: Al Smith vs Thornton Lee | Seventh | 6 out |
| Wednesday, June 13 |
| » Lost to White Sox (23-24), 5-3 | Comiskey Park I (1-5) | 20-24 | Lost 3 |
| » Starters: Steve Gromek vs Joe Haynes | Seventh | 7 out |
| Thursday, June 14 |
| » Lost to White Sox (24-24), 4-3 | Comiskey Park I (1-6) | 20-25 | Lost 4 |
| » Starters: Jim Bagby vs Orval Grove | Seventh | 7 out |
| Friday, June 15 |
| » Defeated Browns (23-24), 5-2 | Sportsman's Park III (2-0) | 21-25 | |
| » Starters: Allie Reynolds vs Lefty West | Seventh | 6½ out |
| Saturday, June 16 |
| » Lost to Browns (24-24), 4-3 | Sportsman's Park III (2-1) | 21-26 | |
| » Starters: Ed Klieman vs Jack Kramer | Seventh | 8 out |
| Tuesday, June 19 |
| » Lost to Tigers (30-21), 4-3 | Tiger Stadium (1-3) | 21-27 | Lost 2 |
| » Starters: Steve Gromek vs Zeb Eaton | Seventh | 7½ out |
| Wednesday, June 20 |
| » Lost to Tigers (31-21), 5-0 | Tiger Stadium (1-4) | 21-28 | Lost 3 |
| » Starters: Al Smith vs Hal Newhouser | Seventh | 8½ out |
| Thursday, June 21 |
| » Lost to Tigers (32-21), 5-1 | Tiger Stadium (1-5) | 21-29 | Lost 4 |
| » Starters: Jim Bagby vs Stubby Overmire | Seventh | 9½ out |
| Friday, June 22 |
| » Defeated White Sox (29-27), 2-1 | Cleveland Stadium (7-5) | 22-29 | |
| » Starters: Thornton Lee vs Allie Reynolds | Seventh | 9 out |
| » Lost to White Sox (30-27), 3-0 | Cleveland Stadium (7-6) | 22-30 | |
| » Starters: Orval Grove vs Ed Klieman | Seventh | 9 out |
| Sunday, June 24 |
| » Defeated White Sox (30-28), 7-3 | Cleveland Stadium (8-6) | 23-30 | |
| » Starters: Bill Dietrich vs Steve Gromek | Seventh | 10½ out |
| » Lost to White Sox (31-28), 7-4 | Cleveland Stadium (8-7) | 23-31 | |
| » Starters: Ed Lopat vs Earl Henry | Seventh | 10½ out |
| Wednesday, June 27 |
| » Defeated Athletics (20-37), 8-2 | Cleveland Stadium (9-7) | 24-31 | |
| » Starters: Russ Christopher vs Al Smith | Sixth | 9½ out |
| Thursday, June 28 |
| » Defeated Athletics (20-38), 11-0 | League Park II (5-7) | 25-31 | Won 2 |
| » Starters: Lou Knerr vs Jim Bagby | Seventh | 9½ out |
| Friday, June 29 |
| » Defeated Athletics (20-39), 4-2 | League Park II (6-7) | 26-31 | Won 3 |
| » Starters: Steve Gerkin vs Allie Reynolds | Sixth | 8½ out |
| Saturday, June 30 |
| » Lost to Senators (30-29), 3-0 | Cleveland Stadium (9-8) | 26-32 | |
| » Starters: Johnny Niggeling vs Steve Gromek | Seventh | 10 out |
| » Lost to Senators (31-29), 7-1 | Cleveland Stadium (9-9) | 26-33 | Lost 2 |
| » Starters: Mickey Haefner vs Ed Klieman | Seventh | 10 out |
| Future Indian Jerry Kenney is born in St. Louis, MO. |
| Sunday, July 1 |
| » Lost to Senators (32-29), 6-5 | Cleveland Stadium (9-10) | 26-34 | Lost 3 |
| » Starters: Dutch Leonard vs Mel Harder | Seventh | 11 out |
| » Defeated Senators (32-30), 6-5 | Cleveland Stadium (10-10) | 27-34 | |
| » Starters: Sandy Ullrich vs Pete Center | Seventh | 11 out |
| Future Indian Billy Rohr is born in San Diego, CA. |
| Tuesday, July 3 |
| » Defeated Yankees (36-29), 5-2 | Cleveland Stadium (11-10) | 28-34 | Won 2 |
| » Starters: Atley Donald vs Al Smith | Seventh | 10 out |
| Wednesday, July 4 |
| » Defeated Yankees (36-30), 4-2 | Cleveland Stadium (12-10) | 29-34 | Won 3 |
| » Starters: Hank Borowy vs Steve Gromek | Seventh | 10 out |
| » Lost to Yankees (37-30), 3-2 | Cleveland Stadium (12-11) | 29-35 | |
| » Starters: Al Gettel vs Allie Reynolds | Seventh | 10 out |
| Thursday, July 5 |
| » Defeated Yankees (37-31), 2-1 | League Park II (7-7) | 30-35 | |
| » Starters: Tiny Bonham vs Ed Klieman | Seventh | 10 out |
| Friday, July 6 |
| » Defeated Red Sox (35-33), 3-2 | Cleveland Stadium (13-11) | 31-35 | Won 2 |
| » Starters: Emmett O'Neill vs Jim Bagby | Sixth | 8½ out |
| » Defeated Red Sox (35-34), 4-2 | Cleveland Stadium (14-11) | 32-35 | Won 3 |
| » Starters: Randy Heflin vs Mel Harder | Sixth | 8½ out |
| Saturday, July 7 |
| » Lost to Red Sox (36-34), 8-6 | League Park II (7-8) | 32-36 | |
| » Starters: Jim Wilson vs Al Smith | Seventh | 9½ out |
| Future Indian Bill Melton is born in Gulfport, MS. |
| Sunday, July 8 |
| » Lost to Red Sox (37-34), 6-0 | Cleveland Stadium (14-12) | 32-37 | Lost 2 |
| » Starters: Dave Ferriss vs Steve Gromek | Seventh | 9½ out |
| » Defeated Red Sox (37-35), 4-2 | Cleveland Stadium (15-12) | 33-37 | |
| » Starters: Clem Hausmann vs Pete Center | Seventh | 9½ out |
| Thursday, July 12 |
| » Defeated Yankees (39-34), 7-4 | Yankee Stadium (3-2) | 34-37 | Won 2 |
| » Starters: Allie Reynolds vs Tiny Bonham | Sixth | 8½ out |
| Friday, July 13 |
| » Defeated Yankees (39-35), 16-4 | Yankee Stadium (4-2) | 35-37 | Won 3 |
| » Starters: Steve Gromek vs Atley Donald | Fifth | 7½ out |
| Saturday, July 14 |
| » Lost to Yankees (40-35), 4-2 | Yankee Stadium (4-3) | 35-38 | |
| » Starters: Ed Klieman vs Bill Bevens | Fifth | 7½ out |
| Sunday, July 15 |
| » Lost to Red Sox (41-35), 6-4 | Fenway Park (1-3) | 35-39 | Lost 2 |
| » Starters: Mel Harder vs Clem Hausmann | Sixth | 7½ out |
| Monday, July 16 |
| » Defeated Red Sox (41-36), 3-2 | Fenway Park (2-3) | 36-39 | |
| » Starters: Allie Reynolds vs Randy Heflin | Sixth | 7½ out |
| Tuesday, July 17 |
| » Defeated Red Sox (41-37), 6-1 | Fenway Park (3-3) | 37-39 | Won 2 |
| » Starters: Steve Gromek vs Jim Wilson | Seventh | 7 out |
| Wednesday, July 18 |
| » Tied Athletics, 2-2 | Shibe Park (1-1) | 37-39 | |
| » Starters: Ed Klieman vs Don Black | Seventh | 8 out |
| Friday, July 20 |
| » Lost to Athletics (27-51), 8-3 | Shibe Park (1-2) | 37-40 | |
| » Starters: Allie Reynolds vs Jesse Flores | Seventh | 8 out |
| » Lost to Athletics (28-51), 3-2 | Shibe Park (1-3) | 37-41 | Lost 2 |
| » Starters: Mel Harder vs Bobo Newsom | Seventh | 8 out |
| Saturday, July 21 |
| » Lost to Senators (43-36), 7-4 | Griffith Stadium (3-1) | 37-42 | Lost 3 |
| » Starters: Al Smith vs Johnny Niggeling | Seventh | 8½ out |
| Sunday, July 22 |
| » Lost to Senators (44-36), 5-4 | Griffith Stadium (3-2) | 37-43 | Lost 4 |
| » Starters: Steve Gromek vs Mickey Haefner | Sixth | 8½ out |
| » Defeated Senators (44-37), 9-3 | Griffith Stadium (4-2) | 38-43 | |
| » Starters: Jim Bagby vs Marino Pieretti | Sixth | 8½ out |
| Monday, July 23 |
| » Defeated Senators (44-38), 2-1 | Griffith Stadium (5-2) | 39-43 | Won 2 |
| » Starters: Ed Klieman vs Johnny Niggeling | Seventh | 7½ out |
| Tuesday, July 24 |
| » Defeated Senators (44-39), 4-0 | Griffith Stadium (6-2) | 40-43 | Won 3 |
| » Starters: Allie Reynolds vs Dutch Leonard | Sixth | 7 out |
| Friday, July 27 |
| » Defeated Browns (41-41), 3-1 | Cleveland Stadium (16-12) | 41-43 | Won 4 |
| » Starters: Nels Potter vs Steve Gromek | Sixth | 7 out |
| Saturday, July 28 |
| » Defeated Browns (41-42), 6-2 | League Park II (8-8) | 42-43 | Won 5 |
| » Starters: Jack Kramer vs Allie Reynolds | Seventh | 7 out |
| Sunday, July 29 |
| » Lost to Browns (42-42), 4-0 | Cleveland Stadium (16-13) | 42-44 | |
| » Starters: Tex Shirley vs Mel Harder | Seventh | 7½ out |
| » Defeated Browns (42-43), 3-0 | Cleveland Stadium (17-13) | 43-44 | |
| » Starters: Al Hollingsworth vs Jim Bagby | Seventh | 7½ out |
| Future Indian Roy Foster is born in Bixby, OK. |
| Tuesday, July 31 |
| » Defeated White Sox (44-45), 6-5 | Cleveland Stadium (18-13) | 44-44 | Won 2 |
| » Starters: Thornton Lee vs Ed Klieman | Fifth | 7½ out |
| Wednesday, August 1 |
| » Lost to White Sox (45-45), 2-1 | League Park II (8-9) | 44-45 | |
| » Starters: Ed Lopat vs Steve Gromek | Fifth | 8½ out |
| Thursday, August 2 |
| » Defeated White Sox (45-46), 13-7 | League Park II (9-9) | 45-45 | |
| » Starters: Johnny Humphries vs Allie Reynolds | Fifth | 8½ out |
| Friday, August 3 |
| » Lost to Browns (43-46), 6-5 | Sportsman's Park III (2-2) | 45-46 | |
| » Starters: Al Smith vs Tex Shirley | Sixth | 8½ out |
| Saturday, August 4 |
| » Lost to Browns (44-46), 8-2 | Sportsman's Park III (2-3) | 45-47 | Lost 2 |
| » Starters: Jim Bagby vs Al Hollingsworth | Seventh | 8½ out |
| Sunday, August 5 |
| » Defeated Browns (44-47), 6-3 | Sportsman's Park III (3-3) | 46-47 | |
| » Starters: Mel Harder vs Bob Muncrief | Seventh | 7½ out |
| » Lost to Browns (45-47), 10-9 | Sportsman's Park III (3-4) | 46-48 | |
| » Starters: Allie Reynolds vs Nels Potter | Seventh | 7½ out |
| Monday, August 6 |
| » Defeated Browns (45-48), 9-7 | Sportsman's Park III (4-4) | 47-48 | |
| » Starters: Pete Center vs Jack Kramer | Fifth | 6½ out |
| » Defeated Browns (45-49), 8-4 | Sportsman's Park III (5-4) | 48-48 | Won 2 |
| » Starters: Steve Gromek vs Sig Jakucki | Fifth | 6½ out |
| Wednesday, August 8 |
| » Defeated Yankees (50-44), 1-0 | Cleveland Stadium (19-13) | 49-48 | Won 3 |
| » Starters: Tiny Bonham vs Al Smith | Fifth | 6 out |
| Thursday, August 9 |
| » Lost to Yankees (51-44), 3-2 | League Park II (9-10) | 49-49 | |
| » Starters: Red Ruffing vs Jim Bagby | Fifth | 7 out |
| Friday, August 10 |
| » Lost to Yankees (52-44), 10-4 | League Park II (9-11) | 49-50 | Lost 2 |
| » Starters: Al Gettel vs Allie Reynolds | Fifth | 7 out |
| Saturday, August 11 |
| » Defeated Yankees (52-45), 5-3 | League Park II (10-11) | 50-50 | |
| » Starters: Monk Dubiel vs Steve Gromek | Fifth | 7 out |
| Sunday, August 12 |
| » Lost to Red Sox (51-52), 7-1 | Cleveland Stadium (19-14) | 50-51 | |
| » Starters: Dave Ferriss vs Mel Harder | Fifth | 8 out |
| » Defeated Red Sox (51-53), 8-2 | Cleveland Stadium (20-14) | 51-51 | |
| » Starters: Otie Clark vs Pete Center | Fifth | 8 out |
| Monday, August 13 |
| » Defeated Red Sox (51-54), 10-0 | Cleveland Stadium (21-14) | 52-51 | Won 2 |
| » Starters: Vic Johnson vs Al Smith | Fifth | 8½ out |
| Tuesday, August 14 |
| » Defeated Red Sox (51-55), 3-0 | League Park II (11-11) | 53-51 | Won 3 |
| » Starters: Randy Heflin vs Jim Bagby | Fifth | 8 out |
| Wednesday, August 15 |
| » Defeated Athletics (34-68), 8-3 | League Park II (12-11) | 54-51 | Won 4 |
| » Starters: Russ Christopher vs Steve Gromek | Fourth | 7 out |
| Thursday, August 16 |
| » Defeated Athletics (34-69), 7-6 | Cleveland Stadium (22-14) | 55-51 | Won 5 |
| » Starters: Jesse Flores vs Pete Center | Fourth | 7 out |
| Friday, August 17 |
| » Defeated Athletics (34-70), 6-4 | League Park II (13-11) | 56-51 | Won 6 |
| » Starters: Bobo Newsom vs Mel Harder | Fourth | 6 out |
| Saturday, August 18 |
| » Defeated Athletics (34-71), 7-4 | League Park II (14-11) | 57-51 | Won 7 |
| » Starters: Lou Knerr vs Jim Bagby | Fourth | 5 out |
| Sunday, August 19 |
| » Lost to Senators (62-48), 7-1 | Cleveland Stadium (22-15) | 57-52 | |
| » Starters: Johnny Niggeling vs Al Smith | Fourth | 5 out |
| » Defeated Senators (62-49), 9-3 | Cleveland Stadium (23-15) | 58-52 | |
| » Starters: Dutch Leonard vs Allie Reynolds | Fourth | 5 out |
| Monday, August 20 |
| » Lost to Senators (63-49), 7-0 | Cleveland Stadium (23-16) | 58-53 | |
| » Starters: Marino Pieretti vs Pete Center | Fourth | 7 out |
| » Lost to Senators (64-49), 6-0 | Cleveland Stadium (23-17) | 58-54 | Lost 2 |
| » Starters: Alex Carrasquel vs Steve Gromek | Fourth | 7 out |
| » Major-league debuts: Dick Kimble (Senators) |
| Tuesday, August 21 |
| » Lost to Senators (65-49), 11-8 | League Park II (14-12) | 58-55 | Lost 3 |
| » Starters: Mickey Haefner vs Ed Klieman | Fifth | 7½ out |
| Wednesday, August 22 |
| » Lost to Senators (66-49), 3-0 | League Park II (14-13) | 58-56 | Lost 4 |
| » Starters: Roger Wolff vs Mel Harder | Sixth | 9 out |
| » Lost to Senators (67-49), 6-5 | League Park II (14-14) | 58-57 | Lost 5 |
| » Starters: Sandy Ullrich vs Steve Gromek | Sixth | 9 out |
| Friday, August 24 |
| » Defeated Tigers (68-49), 4-2 | Cleveland Stadium (24-17) | 59-57 | |
| » Starters: Hal Newhouser vs Bob Feller | Fifth | 8½ out |
| Sunday, August 26 |
| » Defeated Tigers (68-50), 3-1 | Cleveland Stadium (25-17) | 60-57 | Won 2 |
| » Starters: Dizzy Trout vs Allie Reynolds | Fifth | 6½ out |
| » Defeated Tigers (68-51), 5-4 | Cleveland Stadium (26-17) | 61-57 | Won 3 |
| » Starters: Al Benton vs Steve Gromek | Fifth | 6½ out |
| Tuesday, August 28 |
| » Defeated White Sox (60-61), 8-2 | Comiskey Park I (2-6) | 62-57 | Won 4 |
| » Starters: Bob Feller vs Bill Dietrich | Fifth | 6½ out |
| Thursday, August 30 |
| » Tied White Sox, 4-4 | Comiskey Park I (2-6) | 62-57 | |
| » Starters: Pete Center vs Orval Grove | Fifth | 6 out |
| Friday, August 31 |
| » Defeated Tigers (69-53), 7-2 | Tiger Stadium (2-5) | 63-57 | Won 5 |
| » Starters: Allie Reynolds vs Dizzy Trout | Fifth | 5 out |
| Saturday, September 1 |
| » Lost to Tigers (70-53), 5-4 | Tiger Stadium (2-6) | 63-58 | |
| » Starters: Bob Feller vs Hal Newhouser | Fifth | 6 out |
| Sunday, September 2 |
| » Defeated Tigers (70-54), 3-2 | Tiger Stadium (3-6) | 64-58 | |
| » Starters: Jim Bagby vs Les Mueller | Fifth | 5 out |
| Monday, September 3 |
| » Lost to Browns (68-58), 6-3 | Cleveland Stadium (26-18) | 64-59 | |
| » Starters: Bob Muncrief vs Al Smith | Fifth | 7 out |
| » Lost to Browns (69-58), 5-4 | Cleveland Stadium (26-19) | 64-60 | Lost 2 |
| » Starters: Lefty West vs Mel Harder | Fifth | 7 out |
| Wednesday, September 5 |
| » Lost to Red Sox (62-69), 2-1 | Fenway Park (3-4) | 64-61 | Lost 3 |
| » Starters: Bob Feller vs Otie Clark | Fifth | 7½ out |
| » Defeated Red Sox (62-70), 5-2 | Fenway Park (4-4) | 65-61 | |
| » Starters: Allie Reynolds vs Randy Heflin | Fifth | 7½ out |
| Thursday, September 6 |
| » Lost to Red Sox (63-70), 9-3 | Fenway Park (4-5) | 65-62 | |
| » Starters: Ed Klieman vs Pinky Woods | Fifth | 8 out |
| Friday, September 7 |
| » Lost to Red Sox (64-70), 1-0 | Fenway Park (4-6) | 65-63 | Lost 2 |
| » Starters: Mel Harder vs Mike Ryba | Fifth | 9 out |
| Saturday, September 8 |
| » Lost to Red Sox (65-70), 9-4 | Fenway Park (4-7) | 65-64 | Lost 3 |
| » Starters: Jim Bagby vs Vic Johnson | Fifth | 10 out |
| Future Indian Ossie Blanco is born in Caracas, Venezuela. |
| Sunday, September 9 |
| » Defeated Yankees (69-64), 10-3 | Yankee Stadium (5-3) | 66-64 | |
| » Starters: Bob Feller vs Spud Chandler | Fifth | 9½ out |
| » Defeated Yankees (69-65), 4-3 | Yankee Stadium (6-3) | 67-64 | Won 2 |
| » Starters: Allie Reynolds vs Al Gettel | Fifth | 9½ out |
| Monday, September 10 |
| » Lost to Yankees (70-65), 5-1 | Yankee Stadium (6-4) | 67-65 | |
| » Starters: Al Smith vs Tiny Bonham | Fifth | 10 out |
| Wednesday, September 12 |
| » Lost to Senators (81-61), 5-1 | Griffith Stadium (6-3) | 67-66 | Lost 2 |
| » Starters: Steve Gromek vs Roger Wolff | Fifth | 11 out |
| Thursday, September 13 |
| » Lost to Senators (82-61), 4-0 | Griffith Stadium (6-4) | 67-67 | Lost 3 |
| » Starters: Bob Feller vs Walt Masterson | Fifth | 11 out |
| Future Indian Rick Wise is born in Jackson, MI. |
| Friday, September 14 |
| » Lost to Senators (83-61), 6-5 | Griffith Stadium (6-5) | 67-68 | Lost 4 |
| » Starters: Allie Reynolds vs Pete Appleton | Fifth | 12 out |
| Saturday, September 15 |
| » Lost to Athletics (50-91), 6-2 | Shibe Park (1-4) | 67-69 | Lost 5 |
| » Starters: Al Smith vs Don Black | Fifth | 13½ out |
| Sunday, September 16 |
| » Defeated Athletics (50-92), 3-0 | Shibe Park (2-4) | 68-69 | |
| » Starters: Steve Gromek vs Bobo Newsom | Fifth | 13½ out |
| » Lost to Athletics (51-92), 7-5 | Shibe Park (2-5) | 68-70 | |
| » Starters: Pete Center vs Lou Knerr | Fifth | 13½ out |
| Wednesday, September 19 |
| » Defeated Tigers (85-62), 2-0 | League Park II (15-14) | 69-70 | |
| » Starters: Les Mueller vs Bob Feller | Fifth | 12 out |
| Thursday, September 20 |
| » Defeated Tigers (85-63), 6-1 | League Park II (16-14) | 70-70 | Won 2 |
| » Starters: Al Benton vs Allie Reynolds | Fifth | 11 out |
| Saturday, September 22 |
| » Defeated White Sox (71-76), 2-1 | League Park II (17-14) | 71-70 | Won 3 |
| » Starters: Thornton Lee vs Steve Gromek | Fifth | 11 out |
| Sunday, September 23 |
| » Defeated White Sox (71-77), 8-2 | Cleveland Stadium (27-19) | 72-70 | Won 4 |
| » Starters: Orval Grove vs Bob Feller | Fifth | 10 out |
| Tuesday, September 25 |
| Future Indian Steve Arlin is born in Seattle, WA. |
| Wednesday, September 26 |
| » Lost to Tigers (87-64), 11-0 | Tiger Stadium (3-7) | 72-71 | |
| » Starters: Allie Reynolds vs Hal Newhouser | Fifth | 10 out |
| » Defeated Tigers (87-65), 3-2 | Tiger Stadium (4-7) | 73-71 | |
| » Starters: Steve Gromek vs Al Benton | Fifth | 10 out |
| Future Indian Dave Duncan is born in Dallas, TX. |
| Friday, September 28 |
| » Lost to Browns (81-69), 2-1 | Sportsman's Park III (5-5) | 73-72 | |
| » Starters: Bob Feller vs Sam Zoldak | Fifth | 10½ out |
| Saturday, November 10 |
| Future Indian Billy Southworth is born in Madison, WI. |
| Sunday, November 18 |
| Former Indian Morrie Rath dies in Upper Darby, PA at the age of 59. |
| Thursday, November 22 |
| Future Indian Denny Riddleberger is born in Clifton Forge, VA. |
| Thursday, December 20 |
| Future Indian Vince Colbert is born in Washington, DC. |
Game information provided by Retrosheet (www.retrosheet.org) |
