| Monday, January 22 |
| Future Cub Jophery Brown is born in Grambling, LA. |
| Sunday, March 11 |
| Former Cub Sam Mertes dies in San Francisco, CA at the age of 73. |
| Sunday, March 25 |
| Future Cub Jim Ellis is born in Tulare, CA. |
| Wednesday, April 4 |
| Former Cub Dick Cotter dies in Brooklyn, NY at the age of 56. |
| Sunday, April 15 |
| Future Cub Ted Sizemore is born in Gadsden, AL. |
| Tuesday, April 17 |
| » Defeated Cardinals (0-1), 3-2 | Wrigley Field (1-0) | 1-0 | |
| » Starters: Ted Wilks vs Paul Derringer | First | -- |
| » Major-league debuts: Red Schoendienst (Cardinals) |
| Wednesday, April 18 |
| » Major-league debuts: Vic Lombardi (Dodgers) |
| Future Cub Mike Paul is born in Detroit, MI. |
| Thursday, April 19 |
| » Lost to Cardinals (1-1), 8-2 | Wrigley Field (1-1) | 1-1 | |
| » Starters: Harry Brecheen vs Ray Prim | Third | 1 out |
| Friday, April 20 |
| » Lost to Pirates (2-2), 5-4 | Forbes Field (0-1) | 1-2 | Lost 2 |
| » Starters: Hank Wyse vs Rip Sewell | Sixth | 2 out |
| Saturday, April 21 |
| » Defeated Pirates (2-3), 4-3 | Forbes Field (1-1) | 2-2 | |
| » Starters: Paul Derringer vs Preacher Roe | Third | 2 out |
| Sunday, April 22 |
| » Defeated Pirates (2-4), 3-0 | Forbes Field (2-1) | 3-2 | Won 2 |
| » Starters: Bob Chipman vs Fritz Ostermueller | Second | ½ out |
| » Defeated Pirates (2-5), 5-2 | Forbes Field (3-1) | 4-2 | Won 3 |
| » Starters: Ed Hanyzewski vs Al Gerheauser | Second | ½ out |
| Wednesday, April 25 |
| » Defeated Reds (3-4), 4-0 | Crosley Field (1-0) | 5-2 | Won 4 |
| » Starters: Claude Passeau vs Bucky Walters | Second | ½ out |
| Friday, April 27 |
| » Defeated Pirates (2-6), 7-3 | Wrigley Field (2-1) | 6-2 | Won 5 |
| » Starters: Rip Sewell vs Paul Derringer | Second | 1 out |
| Saturday, April 28 |
| » Defeated Pirates (2-7), 6-0 | Wrigley Field (3-1) | 7-2 | Won 6 |
| » Starters: Max Butcher vs Hank Wyse | First | -- |
| Sunday, April 29 |
| » Lost to Pirates (3-7), 6-2 | Wrigley Field (3-2) | 7-3 | |
| » Starters: Preacher Roe vs Bob Chipman | Second | ½ out |
| » Lost to Pirates (4-7), 5-4 | Wrigley Field (3-3) | 7-4 | Lost 2 |
| » Starters: Nick Strincevich vs Jorge Comellas | Second | ½ out |
| Saturday, May 5 |
| » Defeated Cardinals (6-6), 5-1 | Sportsman's Park III (1-0) | 8-4 | |
| » Starters: Paul Derringer vs Ted Wilks | Second | 1½ out |
| Sunday, May 6 |
| » Lost to Cardinals (7-6), 6-2 | Sportsman's Park III (1-1) | 8-5 | |
| » Starters: Bob Chipman vs Max Lanier | Third | 3 out |
| » Lost to Cardinals (8-6), 5-1 | Sportsman's Park III (1-2) | 8-6 | Lost 2 |
| » Starters: Hank Wyse vs Mort Cooper | Third | 3 out |
| Wednesday, May 9 |
| » Lost to Phillies (4-13), 5-2 | Shibe Park (0-1) | 8-7 | Lost 3 |
| » Starters: Paul Derringer vs Bill Lee | Third | 4 out |
| Friday, May 11 |
| » Defeated Phillies (4-14), 7-1 | Shibe Park (1-1) | 9-7 | |
| » Starters: Hank Wyse vs Charlie Sproull | Third | 4 out |
| Saturday, May 12 |
| » Defeated Braves (7-10), 13-12 | Braves Field (1-0) | 10-7 | Won 2 |
| » Starters: Ray Prim vs Al Javery | Third | 4 out |
| Sunday, May 13 |
| » Lost to Braves (8-10), 3-2 | Braves Field (1-1) | 10-8 | |
| » Starters: Claude Passeau vs Nate Andrews | Third | 4½ out |
| Monday, May 14 |
| » Lost to Giants (17-5), 6-5 | Polo Grounds V (0-1) | 10-9 | Lost 2 |
| » Starters: Bob Chipman vs Slim Emmerich | Third | 5½ out |
| » Major-league debuts: Slim Emmerich (Giants) |
| Tuesday, May 15 |
| » Lost to Giants (18-5), 5-4 | Polo Grounds V (0-2) | 10-10 | Lost 3 |
| » Starters: Paul Derringer vs Van Mungo | Third | 6½ out |
| Wednesday, May 16 |
| » Lost to Giants (19-5), 6-0 | Polo Grounds V (0-3) | 10-11 | Lost 4 |
| » Starters: Hank Wyse vs Bill Voiselle | Third | 7½ out |
| Thursday, May 17 |
| » Lost to Giants (20-5), 8-5 | Polo Grounds V (0-4) | 10-12 | Lost 5 |
| » Starters: Claude Passeau vs Andy Hansen | Fourth | 8½ out |
| » Major-league debuts: Al Gardella (Giants) |
| Friday, May 18 |
| » Lost to Dodgers (17-7), 15-12 | Ebbets Field (0-1) | 10-13 | Lost 6 |
| » Starters: Paul Erickson vs Lee Pfund | Fifth | 9 out |
| Sunday, May 20 |
| » Defeated Dodgers (17-8), 4-2 | Ebbets Field (1-1) | 11-13 | |
| » Starters: Paul Derringer vs Curt Davis | Fourth | 8 out |
| » Defeated Dodgers (17-9), 4-1 | Ebbets Field (2-1) | 12-13 | Won 2 |
| » Starters: Hank Wyse vs Hal Gregg | Fourth | 8 out |
| Wednesday, May 23 |
| » Defeated Phillies (7-22), 5-3 | Wrigley Field (4-3) | 13-13 | Won 3 |
| » Starters: Charley Schanz vs Claude Passeau | Fourth | 7½ out |
| Thursday, May 24 |
| » Lost to Phillies (8-22), 6-3 | Wrigley Field (4-4) | 13-14 | |
| » Starters: Dick Barrett vs Paul Derringer | Fifth | 8½ out |
| Friday, May 25 |
| » Defeated Phillies (8-23), 4-3 | Wrigley Field (5-4) | 14-14 | |
| » Starters: Whit Wyatt vs Hank Wyse | Fourth | 8½ out |
| Saturday, May 26 |
| » Defeated Phillies (8-24), 2-1 | Wrigley Field (6-4) | 15-14 | Won 2 |
| » Starters: Bill Lee vs Paul Erickson | Fourth | 8½ out |
| Sunday, May 27 |
| » Defeated Dodgers (18-14), 6-1 | Wrigley Field (7-4) | 16-14 | Won 3 |
| » Starters: Hal Gregg vs Ray Prim | Fourth | 7 out |
| » Tied Dodgers, 2-2 | Wrigley Field (7-4) | 16-14 | |
| » Starters: Vic Lombardi vs Claude Passeau | Fourth | 7 out |
| Monday, May 28 |
| » Defeated Dodgers (18-15), 5-3 | Wrigley Field (8-4) | 17-14 | Won 4 |
| » Starters: Ray Hathaway vs Paul Derringer | Second | 6½ out |
| Tuesday, May 29 |
| » Lost to Dodgers (19-15), 10-3 | Wrigley Field (8-5) | 17-15 | |
| » Starters: Ben Chapman vs Mack Stewart | Fourth | 6½ out |
| Wednesday, May 30 |
| » Lost to Giants (26-10), 8-6 | Wrigley Field (8-6) | 17-16 | Lost 2 |
| » Starters: Andy Hansen vs Hank Wyse | Fourth | 6½ out |
| » Defeated Giants (26-11), 11-2 | Wrigley Field (9-6) | 18-16 | |
| » Starters: Bill Voiselle vs Bob Chipman | Fourth | 6½ out |
| Saturday, June 2 |
| » Lost to Braves (14-20), 5-4 | Wrigley Field (9-7) | 18-17 | |
| » Starters: Johnny Hutchings vs Paul Derringer | Fifth | 7 out |
| Sunday, June 3 |
| » Lost to Braves (15-20), 2-1 | Wrigley Field (9-8) | 18-18 | Lost 2 |
| » Starters: Bob Logan vs Hank Wyse | Fifth | 6 out |
| » Defeated Braves (15-21), 3-1 | Wrigley Field (10-8) | 19-18 | |
| » Starters: Jim Tobin vs Claude Passeau | Fifth | 6 out |
| Thursday, June 7 |
| » Lost to Cardinals (24-18), 6-4 | Sportsman's Park III (1-3) | 19-19 | |
| » Starters: Paul Erickson vs Jack Creel | Sixth | 6½ out |
| Future Cub George Mitterwald is born in Berkeley, CA. |
| Friday, June 8 |
| » Defeated Reds (21-20), 7-3 | Wrigley Field (11-8) | 20-19 | |
| » Starters: Hod Lisenbee vs Paul Derringer | Fifth | 6 out |
| Saturday, June 9 |
| » Defeated Reds (21-21), 5-1 | Wrigley Field (12-8) | 21-19 | Won 2 |
| » Starters: Boom-Boom Beck vs Hank Wyse | Fifth | 5 out |
| Sunday, June 10 |
| » Defeated Reds (21-22), 10-7 | Wrigley Field (13-8) | 22-19 | Won 3 |
| » Starters: Ed Heusser vs Ray Prim | Fourth | 3 out |
| » Defeated Reds (21-23), 7-4 | Wrigley Field (14-8) | 23-19 | Won 4 |
| » Starters: Frank Dasso vs Claude Passeau | Fourth | 3 out |
| Tuesday, June 12 |
| » Lost to Pirates (27-21), 9-3 | Forbes Field (3-2) | 23-20 | |
| » Starters: Hank Wyse vs Al Gerheauser | Fifth | 3 out |
| Thursday, June 14 |
| » Lost to Pirates (28-21), 5-2 | Forbes Field (3-3) | 23-21 | Lost 2 |
| » Starters: Bob Chipman vs Max Butcher | Sixth | 3½ out |
| » Lost to Pirates (29-21), 6-5 | Forbes Field (3-4) | 23-22 | Lost 3 |
| » Starters: Paul Derringer vs Rip Sewell | Sixth | 3½ out |
| Friday, June 15 |
| » Defeated Reds (22-25), 8-1 | Crosley Field (2-0) | 24-22 | |
| » Starters: Claude Passeau vs Vern Kennedy | Fourth | 3 out |
| » Defeated Reds (22-26), 3-0 | Crosley Field (3-0) | 25-22 | Won 2 |
| » Starters: Hy Vandenberg vs Bucky Walters | Fourth | 3 out |
| Sunday, June 17 |
| » Defeated Reds (22-27), 3-1 | Crosley Field (4-0) | 26-22 | Won 3 |
| » Starters: Hank Wyse vs Ed Heusser | Fifth | 2 out |
| Wednesday, June 20 |
| » Defeated Pirates (30-25), 5-3 | Wrigley Field (15-8) | 27-22 | Won 4 |
| » Starters: Max Butcher vs Bob Chipman | Second | 3 out |
| Future Cub Ray Newman is born in Evansville, IN. |
| Thursday, June 21 |
| » Defeated Pirates (30-26), 5-4 | Wrigley Field (16-8) | 28-22 | Won 5 |
| » Starters: Preacher Roe vs Hank Wyse | Second | 3 out |
| Friday, June 22 |
| » Lost to Cardinals (31-24), 5-2 | Wrigley Field (16-9) | 28-23 | |
| » Starters: Ken Burkhart vs Paul Derringer | Third | 4 out |
| Saturday, June 23 |
| » Lost to Cardinals (32-24), 6-4 | Wrigley Field (16-10) | 28-24 | Lost 2 |
| » Starters: Harry Brecheen vs Hy Vandenberg | Fourth | 5 out |
| Sunday, June 24 |
| » Lost to Cardinals (33-24), 8-2 | Wrigley Field (16-11) | 28-25 | Lost 3 |
| » Starters: Red Barrett vs Ray Prim | Fifth | 5 out |
| » Defeated Cardinals (33-25), 6-3 | Wrigley Field (17-11) | 29-25 | |
| » Starters: Jack Creel vs Claude Passeau | Fifth | 5 out |
| Wednesday, June 27 |
| » Lost to Dodgers (38-23), 6-5 | Ebbets Field (2-2) | 29-26 | |
| » Starters: Paul Derringer vs Hal Gregg | Fourth | 6 out |
| Thursday, June 28 |
| » Defeated Dodgers (38-24), 11-8 | Ebbets Field (3-2) | 30-26 | |
| » Starters: Claude Passeau vs Lee Pfund | Fourth | 5 out |
| Friday, June 29 |
| » Lost to Dodgers (39-24), 5-4 | Ebbets Field (3-3) | 30-27 | |
| » Starters: Ray Prim vs Art Herring | Fourth | 5 out |
| » Defeated Dodgers (39-25), 3-1 | Ebbets Field (4-3) | 31-27 | |
| » Starters: Hy Vandenberg vs Vic Lombardi | Fourth | 5 out |
| Saturday, June 30 |
| » Defeated Giants (36-30), 5-3 | Polo Grounds V (1-4) | 32-27 | Won 2 |
| » Starters: Paul Erickson vs Slim Emmerich | Fourth | 5 out |
| Sunday, July 1 |
| » Lost to Giants (37-30), 7-4 | Polo Grounds V (1-5) | 32-28 | |
| » Starters: Paul Derringer vs Van Mungo | Fourth | 5 out |
| » Defeated Giants (37-31), 4-3 | Polo Grounds V (2-5) | 33-28 | |
| » Starters: Hank Wyse vs Jack Brewer | Fourth | 5 out |
| Tuesday, July 3 |
| » Defeated Braves (33-32), 24-2 | Braves Field (2-1) | 34-28 | Won 2 |
| » Starters: Claude Passeau vs Nate Andrews | Third | 4 out |
| Wednesday, July 4 |
| » Defeated Braves (33-33), 5-3 | Braves Field (3-1) | 35-28 | Won 3 |
| » Starters: Paul Erickson vs Bob Logan | Second | 3 out |
| » Defeated Braves (33-34), 7-6 | Braves Field (4-1) | 36-28 | Won 4 |
| » Starters: Hy Vandenberg vs Johnny Hutchings | Second | 3 out |
| Thursday, July 5 |
| » Defeated Braves (33-35), 3-2 | Braves Field (5-1) | 37-28 | Won 5 |
| » Starters: Hank Wyse vs Jim Tobin | Second | 3 out |
| Friday, July 6 |
| » Defeated Phillies (21-55), 11-3 | Shibe Park (2-1) | 38-28 | Won 6 |
| » Starters: Ray Starr vs Don Grate | Second | 2½ out |
| » Defeated Phillies (21-56), 5-1 | Shibe Park (3-1) | 39-28 | Won 7 |
| » Starters: Paul Derringer vs Dick Mauney | Second | 2½ out |
| » Major-league debuts: Don Grate (Phillies) |
| Saturday, July 7 |
| » Defeated Phillies (21-57), 3-0 | Shibe Park (4-1) | 40-28 | Won 8 |
| » Starters: Claude Passeau vs Charley Schanz | Second | 2½ out |
| Sunday, July 8 |
| » Defeated Phillies (21-58), 12-6 | Shibe Park (5-1) | 41-28 | Won 9 |
| » Starters: Paul Erickson vs Whit Wyatt | First | -- |
| » Defeated Phillies (21-59), 9-2 | Shibe Park (6-1) | 42-28 | Won 10 |
| » Starters: Hank Wyse vs Dick Barrett | First | -- |
| Thursday, July 12 |
| » Defeated Braves (37-37), 6-1 | Wrigley Field (18-11) | 43-28 | Won 11 |
| » Starters: Jim Tobin vs Hank Wyse | First | -- |
| » Lost to Braves (38-37), 3-1 | Wrigley Field (18-12) | 43-29 | |
| » Starters: Nate Andrews vs Claude Passeau | First | -- |
| Friday, July 13 |
| » Defeated Braves (38-38), 2-0 | Wrigley Field (19-12) | 44-29 | |
| » Starters: Bob Logan vs Ray Prim | First | -- |
| Saturday, July 14 |
| » Defeated Braves (38-39), 6-5 | Wrigley Field (20-12) | 45-29 | Won 2 |
| » Starters: Don Hendrickson vs Paul Derringer | First | -- |
| Sunday, July 15 |
| » Defeated Giants (42-39), 5-3 | Wrigley Field (21-12) | 46-29 | Won 3 |
| » Starters: Rube Fischer vs Hy Vandenberg | First | -- |
| » Defeated Giants (42-40), 7-2 | Wrigley Field (22-12) | 47-29 | Won 4 |
| » Starters: Jack Brewer vs Hank Wyse | First | -- |
| Monday, July 16 |
| » Defeated Giants (42-41), 4-3 | Wrigley Field (23-12) | 48-29 | Won 5 |
| » Starters: Van Mungo vs Claude Passeau | First | -- |
| Tuesday, July 17 |
| » Lost to Giants (43-41), 2-1 | Wrigley Field (23-13) | 48-30 | |
| » Starters: Bill Voiselle vs Paul Erickson | First | -- |
| Wednesday, July 18 |
| » Defeated Dodgers (46-37), 5-0 | Wrigley Field (24-13) | 49-30 | |
| » Starters: Curt Davis vs Ray Prim | First | -- |
| » Lost to Dodgers (47-37), 9-5 | Wrigley Field (24-14) | 49-31 | |
| » Starters: Cy Buker vs Lon Warneke | First | -- |
| Thursday, July 19 |
| » Defeated Dodgers (47-38), 3-1 | Wrigley Field (25-14) | 50-31 | |
| » Starters: Vic Lombardi vs Hank Wyse | First | -- |
| Saturday, July 21 |
| » Defeated Phillies (24-66), 5-3 | Wrigley Field (26-14) | 51-31 | Won 2 |
| » Starters: Dick Mauney vs Paul Derringer | First | -- |
| Sunday, July 22 |
| » Defeated Phillies (24-67), 8-5 | Wrigley Field (27-14) | 52-31 | Won 3 |
| » Starters: Charley Schanz vs Ray Prim | First | -- |
| » Lost to Phillies (25-67), 11-6 | Wrigley Field (27-15) | 52-32 | |
| » Starters: Jack Kraus vs Hank Wyse | First | -- |
| Tuesday, July 24 |
| » Defeated Phillies (25-68), 8-3 | Wrigley Field (28-15) | 53-32 | |
| » Starters: Dick Barrett vs Bob Chipman | First | -- |
| Thursday, July 26 |
| » Defeated Reds (40-43), 2-1 | Wrigley Field (29-15) | 54-32 | Won 2 |
| » Starters: Ed Heusser vs Hank Wyse | First | -- |
| Friday, July 27 |
| » Defeated Reds (40-44), 2-1 | Wrigley Field (30-15) | 55-32 | Won 3 |
| » Starters: Bucky Walters vs Claude Passeau | First | -- |
| Saturday, July 28 |
| » Defeated Reds (40-45), 8-3 | Wrigley Field (31-15) | 56-32 | Won 4 |
| » Starters: Arnold Carter vs Paul Derringer | First | -- |
| Sunday, July 29 |
| » Defeated Reds (40-46), 4-1 | Wrigley Field (32-15) | 57-32 | Won 5 |
| » Starters: Joe Bowman vs Hank Wyse | First | -- |
| » Defeated Reds (40-47), 3-2 | Wrigley Field (33-15) | 58-32 | Won 6 |
| » Starters: Vern Kennedy vs Hank Borowy | First | -- |
| Wednesday, August 1 |
| » Lost to Pirates (50-46), 1-0 | Wrigley Field (33-16) | 58-33 | |
| » Starters: Max Butcher vs Claude Passeau | First | -- |
| Thursday, August 2 |
| » Defeated Pirates (50-47), 1-0 | Wrigley Field (34-16) | 59-33 | |
| » Starters: Preacher Roe vs Paul Derringer | First | -- |
| Friday, August 3 |
| » Defeated Reds (42-50), 11-5 | Crosley Field (5-0) | 60-33 | Won 2 |
| » Starters: Hank Wyse vs Joe Bowman | First | -- |
| » Defeated Reds (42-51), 9-1 | Crosley Field (6-0) | 61-33 | Won 3 |
| » Starters: Hank Borowy vs Vern Kennedy | First | -- |
| Saturday, August 4 |
| » Lost to Reds (43-51), 4-3 | Crosley Field (6-1) | 61-34 | |
| » Starters: Hy Vandenberg vs Ed Heusser | First | -- |
| Sunday, August 5 |
| » Defeated Reds (43-52), 12-5 | Crosley Field (7-1) | 62-34 | |
| » Starters: Paul Erickson vs Howie Fox | First | -- |
| » Defeated Reds (43-53), 2-1 | Crosley Field (8-1) | 63-34 | Won 2 |
| » Starters: Claude Passeau vs Joe Bowman | First | -- |
| Wednesday, August 8 |
| » Defeated Braves (46-56), 5-2 | Braves Field (6-1) | 64-34 | Won 3 |
| » Starters: Ray Prim vs Nate Andrews | First | -- |
| » Defeated Braves (46-57), 3-2 | Braves Field (7-1) | 65-34 | Won 4 |
| » Starters: Hank Wyse vs Jim Tobin | First | -- |
| Thursday, August 9 |
| » Lost to Braves (47-57), 7-3 | Braves Field (7-2) | 65-35 | |
| » Starters: Paul Derringer vs Bill Lee | First | -- |
| Friday, August 10 |
| » Lost to Braves (48-57), 2-1 | Braves Field (7-3) | 65-36 | Lost 2 |
| » Starters: Hank Borowy vs Al Javery | First | -- |
| Saturday, August 11 |
| » Defeated Braves (48-58), 8-0 | Braves Field (8-3) | 66-36 | |
| » Starters: Claude Passeau vs Bob Logan | First | -- |
| Sunday, August 12 |
| » Defeated Phillies (28-77), 4-3 | Shibe Park (7-1) | 67-36 | Won 2 |
| » Starters: Paul Erickson vs Dick Mauney | First | -- |
| » Defeated Phillies (28-78), 12-6 | Shibe Park (8-1) | 68-36 | Won 3 |
| » Starters: Hank Wyse vs Charlie Sproull | First | -- |
| Monday, August 13 |
| » Defeated Phillies (28-79), 4-1 | Shibe Park (9-1) | 69-36 | Won 4 |
| » Starters: Paul Derringer vs Dick Barrett | First | -- |
| Tuesday, August 14 |
| » Lost to Phillies (29-79), 2-1 | Shibe Park (9-2) | 69-37 | |
| » Starters: Ray Prim vs Oscar Judd | First | -- |
| Former Cub Tommy Clarke dies in Corona, NY at the age of 58. |
| Wednesday, August 15 |
| » Defeated Dodgers (61-47), 20-6 | Ebbets Field (5-3) | 70-37 | |
| » Starters: Hank Borowy vs Art Herring | First | -- |
| Thursday, August 16 |
| » Lost to Dodgers (62-47), 2-1 | Ebbets Field (5-4) | 70-38 | |
| » Starters: Hank Wyse vs Tom Seats | First | -- |
| Friday, August 17 |
| » Defeated Dodgers (62-48), 4-3 | Ebbets Field (6-4) | 71-38 | |
| » Starters: Claude Passeau vs Hal Gregg | First | -- |
| Saturday, August 18 |
| » Defeated Dodgers (62-49), 7-3 | Ebbets Field (7-4) | 72-38 | Won 2 |
| » Starters: Paul Derringer vs Cy Buker | First | -- |
| Sunday, August 19 |
| » Defeated Giants (62-53), 3-1 | Polo Grounds V (3-5) | 73-38 | Won 3 |
| » Starters: Ray Prim vs Harry Feldman | First | -- |
| » Defeated Giants (62-54), 8-0 | Polo Grounds V (4-5) | 74-38 | Won 4 |
| » Starters: Hank Borowy vs Adrian Zabala | First | -- |
| Monday, August 20 |
| » Lost to Giants (63-54), 9-3 | Polo Grounds V (4-6) | 74-39 | |
| » Starters: Hank Wyse vs Van Mungo | First | -- |
| Tuesday, August 21 |
| » Lost to Giants (64-54), 4-3 | Polo Grounds V (4-7) | 74-40 | Lost 2 |
| » Starters: Claude Passeau vs Jack Brewer | First | -- |
| Friday, August 24 |
| » Lost to Cardinals (71-47), 1-0 | Wrigley Field (34-17) | 74-41 | Lost 3 |
| » Starters: Harry Brecheen vs Hank Borowy | First | -- |
| Saturday, August 25 |
| » Lost to Cardinals (72-47), 3-1 | Wrigley Field (34-18) | 74-42 | Lost 4 |
| » Starters: Ken Burkhart vs Ray Prim | First | -- |
| Sunday, August 26 |
| » Lost to Cardinals (73-47), 5-1 | Wrigley Field (34-19) | 74-43 | Lost 5 |
| » Starters: Red Barrett vs Paul Derringer | First | -- |
| Tuesday, August 28 |
| » Defeated Pirates (65-61), 6-3 | Forbes Field (4-4) | 75-43 | |
| » Starters: Hank Borowy vs Fritz Ostermueller | First | -- |
| Wednesday, August 29 |
| » Defeated Pirates (65-62), 2-0 | Forbes Field (5-4) | 76-43 | Won 2 |
| » Starters: Ray Prim vs Nick Strincevich | First | -- |
| Thursday, August 30 |
| » Lost to Pirates (66-62), 6-4 | Forbes Field (5-5) | 76-44 | |
| » Starters: Paul Derringer vs Preacher Roe | First | -- |
| Friday, August 31 |
| » Lost to Cardinals (74-49), 4-1 | Sportsman's Park III (1-4) | 76-45 | Lost 2 |
| » Starters: Hank Wyse vs Harry Brecheen | First | -- |
| Saturday, September 1 |
| » Lost to Cardinals (75-49), 3-2 | Sportsman's Park III (1-5) | 76-46 | Lost 3 |
| » Starters: Claude Passeau vs George Dockins | First | -- |
| Sunday, September 2 |
| » Defeated Cardinals (75-50), 4-1 | Sportsman's Park III (2-5) | 77-46 | |
| » Starters: Hank Borowy vs Ken Burkhart | First | -- |
| » Lost to Cardinals (76-50), 4-0 | Sportsman's Park III (2-6) | 77-47 | |
| » Starters: Ray Prim vs Red Barrett | First | -- |
| Monday, September 3 |
| » Defeated Reds (49-76), 7-2 | Wrigley Field (35-19) | 78-47 | |
| » Starters: Ed Heusser vs Paul Derringer | First | -- |
| » Defeated Reds (49-77), 7-1 | Wrigley Field (36-19) | 79-47 | Won 2 |
| » Starters: Vern Kennedy vs Hank Wyse | First | -- |
| Wednesday, September 5 |
| » Defeated Giants (71-59), 5-2 | Wrigley Field (37-19) | 80-47 | Won 3 |
| » Starters: Adrian Zabala vs Ray Prim | First | -- |
| » Defeated Giants (71-60), 10-2 | Wrigley Field (38-19) | 81-47 | Won 4 |
| » Starters: Jack Brewer vs Claude Passeau | First | -- |
| Thursday, September 6 |
| » Defeated Giants (71-61), 6-1 | Wrigley Field (39-19) | 82-47 | Won 5 |
| » Starters: Bill Voiselle vs Hank Borowy | First | -- |
| Friday, September 7 |
| » Lost to Giants (72-61), 2-0 | Wrigley Field (39-20) | 82-48 | |
| » Starters: Sal Maglie vs Hank Wyse | First | -- |
| Saturday, September 8 |
| » Lost to Giants (73-61), 3-0 | Wrigley Field (39-21) | 82-49 | Lost 2 |
| » Starters: Harry Feldman vs Paul Derringer | First | -- |
| Sunday, September 9 |
| » Defeated Braves (58-76), 9-1 | Wrigley Field (40-21) | 83-49 | |
| » Starters: Al Javery vs Ray Prim | First | -- |
| » Defeated Braves (58-77), 4-0 | Wrigley Field (41-21) | 84-49 | Won 2 |
| » Starters: Elmer Singleton vs Claude Passeau | First | -- |
| Monday, September 10 |
| » Lost to Braves (59-77), 2-0 | Wrigley Field (41-22) | 84-50 | |
| » Starters: Ed Wright vs Bob Chipman | First | -- |
| Tuesday, September 11 |
| » Defeated Braves (59-78), 5-4 | Wrigley Field (42-22) | 85-50 | |
| » Starters: Bill Lee vs Hank Borowy | First | -- |
| Wednesday, September 12 |
| » Defeated Phillies (42-98), 4-0 | Wrigley Field (43-22) | 86-50 | Won 2 |
| » Starters: Dick Barrett vs Hank Wyse | First | -- |
| Friday, September 14 |
| » Lost to Phillies (43-98), 4-3 | Wrigley Field (43-23) | 86-51 | |
| » Starters: Hugh Mulcahy vs Paul Derringer | First | -- |
| » Defeated Phillies (43-99), 6-0 | Wrigley Field (44-23) | 87-51 | |
| » Starters: Jack Kraus vs Claude Passeau | First | -- |
| Saturday, September 15 |
| » Lost to Dodgers (78-61), 12-5 | Wrigley Field (44-24) | 87-52 | |
| » Starters: Tom Seats vs Claude Passeau | First | -- |
| » Defeated Dodgers (78-62), 7-6 | Wrigley Field (45-24) | 88-52 | |
| » Starters: Les Webber vs Hank Borowy | First | -- |
| Sunday, September 16 |
| » Defeated Dodgers (78-63), 3-2 | Wrigley Field (46-24) | 89-52 | Won 2 |
| » Starters: Ralph Branca vs Ray Prim | First | -- |
| » Defeated Dodgers (78-64), 4-2 | Wrigley Field (47-24) | 90-52 | Won 3 |
| » Starters: Tom Seats vs Hank Wyse | First | -- |
| Future Cub Hector Torres is born in Monterrey, Mexico. |
| Monday, September 17 |
| » Lost to Dodgers (79-64), 4-0 | Wrigley Field (47-25) | 90-53 | |
| » Starters: Art Herring vs Paul Derringer | First | -- |
| Tuesday, September 18 |
| » Lost to Cardinals (88-56), 3-2 | Sportsman's Park III (2-7) | 90-54 | Lost 2 |
| » Starters: Claude Passeau vs Red Barrett | First | -- |
| Wednesday, September 19 |
| » Defeated Cardinals (88-57), 4-1 | Sportsman's Park III (3-7) | 91-54 | |
| » Starters: Hank Borowy vs George Dockins | First | -- |
| Thursday, September 20 |
| » Lost to Cardinals (89-57), 2-0 | Sportsman's Park III (3-8) | 91-55 | |
| » Starters: Ray Prim vs Harry Brecheen | First | -- |
| Friday, September 21 |
| Former Cub Bert Humphries dies in Orlando, FL at the age of 65. |
| Sunday, September 23 |
| » Defeated Pirates (80-68), 7-3 | Wrigley Field (48-25) | 92-55 | |
| » Starters: Preacher Roe vs Hank Wyse | First | -- |
| Tuesday, September 25 |
| » Defeated Cardinals (91-58), 6-5 | Wrigley Field (49-25) | 93-55 | Won 2 |
| » Starters: Harry Brecheen vs Hank Borowy | First | -- |
| Wednesday, September 26 |
| » Lost to Cardinals (92-58), 11-6 | Wrigley Field (49-26) | 93-56 | |
| » Starters: Red Barrett vs Claude Passeau | First | -- |
| Thursday, September 27 |
| » Defeated Reds (61-89), 3-1 | Crosley Field (9-1) | 94-56 | |
| » Starters: Hank Wyse vs Ed Heusser | First | -- |
| » Defeated Reds (61-90), 7-4 | Crosley Field (10-1) | 95-56 | Won 2 |
| » Starters: Paul Derringer vs Vern Kennedy | First | -- |
| Saturday, September 29 |
| » Defeated Pirates (82-70), 4-3 | Forbes Field (6-5) | 96-56 | Won 3 |
| » Starters: Hank Borowy vs Fritz Ostermueller | First | -- |
| » Defeated Pirates (82-71), 5-0 | Forbes Field (7-5) | 97-56 | Won 4 |
| » Starters: Hy Vandenberg vs Rip Sewell | First | -- |
| Sunday, September 30 |
| » Defeated Pirates (82-72), 5-3 | Forbes Field (8-5) | 98-56 | Won 5 |
| » Starters: Bob Chipman vs Ken Gables | First | -- |
| Thursday, October 18 |
| Future Cub Don Young is born in Houston, TX. |
| Saturday, October 27 |
| Future Cub Mike Lum is born in Honolulu, HI. |
| Saturday, November 3 |
| Future Cub Ken Holtzman is born in St. Louis, MO. |
| Tuesday, November 20 |
| Future Cub Jay Johnstone is born in Manchester, CT. Future Cub Rick Monday is born in Batesville, AR. |
| Thursday, December 6 |
| Future Cub Larry Bowa is born in Sacramento, CA. |
| Wednesday, December 19 |
| Future Cub Geoff Zahn is born in Baltimore, MD. |
Game information provided by Retrosheet (www.retrosheet.org) |
