| Wednesday, January 5 |
| Future Indian Tom Kelley is born in Manchester, CT. |
| Tuesday, January 11 |
| Future Indian Frank Baker is born in Bartow, FL. |
| Thursday, February 17 |
| Future Indian Dick Bosman is born in Kenosha, WI. |
| Tuesday, February 29 |
| Future Indian Steve Mingori is born in Kansas City, MO. |
| Wednesday, March 1 |
| Future Indian Vern Fuller is born in Menomonie, WI. |
| Friday, March 10 |
| Future Indian Johnny Briggs is born in Paterson, NJ. |
| Wednesday, April 19 |
| » Lost to White Sox (1-0), 3-1 | Comiskey Park I (0-1) | 0-1 | |
| » Starters: Al Smith vs Orval Grove | Fifth | 1½ out |
| » Major-league debuts: Paul O'Dea (Indians) |
| Friday, April 21 |
| » Defeated Tigers (0-4), 7-4 | Cleveland Stadium (1-0) | 1-1 | |
| » Starters: Stubby Overmire vs Allie Reynolds | Third | 2 out |
| Sunday, April 23 |
| » Lost to Tigers (1-4), 6-2 | Cleveland Stadium (1-1) | 1-2 | |
| » Starters: Dizzy Trout vs Ed Klieman | Sixth | 4 out |
| » Lost to Tigers (2-4), 4-3 | Cleveland Stadium (1-2) | 1-3 | Lost 2 |
| » Starters: Rufe Gentry vs Al Smith | Sixth | 4 out |
| Tuesday, April 25 |
| » Major-league debuts: Freddy Schmidt and Ted Wilks (Cardinals) |
| Wednesday, April 26 |
| » Lost to Browns (7-0), 5-2 | Sportsman's Park III (0-1) | 1-4 | Lost 3 |
| » Starters: Allie Reynolds vs Steve Sundra | Seventh | 5 out |
| Thursday, April 27 |
| » Lost to Browns (8-0), 5-1 | Sportsman's Park III (0-2) | 1-5 | Lost 4 |
| » Starters: Red Embree vs Nels Potter | Seventh | 6 out |
| Friday, April 28 |
| » Defeated Tigers (3-5), 2-1 | Tiger Stadium (1-0) | 2-5 | |
| » Starters: Mel Harder vs Dizzy Trout | Seventh | 6 out |
| Saturday, April 29 |
| » Defeated Tigers (3-6), 7-6 | Tiger Stadium (2-0) | 3-5 | Won 2 |
| » Starters: Paul Calvert vs Rufe Gentry | Sixth | 5 out |
| Sunday, April 30 |
| » Defeated Tigers (3-7), 2-1 | Tiger Stadium (3-0) | 4-5 | Won 3 |
| » Starters: Vern Kennedy vs Stubby Overmire | Fourth | 5 out |
| » Lost to Tigers (4-7), 4-2 | Tiger Stadium (3-1) | 4-6 | |
| » Starters: Allie Reynolds vs Johnny Gorsica | Fourth | 5 out |
| Monday, May 1 |
| » Defeated White Sox (3-7), 9-3 | League Park II (1-0) | 5-6 | |
| » Starters: Thornton Lee vs Hal Kleine | Third | 4½ out |
| Tuesday, May 2 |
| » Lost to White Sox (4-7), 3-2 | League Park II (1-1) | 5-7 | |
| » Starters: Bill Dietrich vs Al Smith | Fourth | 4½ out |
| Wednesday, May 3 |
| » Defeated White Sox (4-8), 9-4 | League Park II (2-1) | 6-7 | |
| » Starters: Buck Ross vs Mel Harder | Third | 4½ out |
| Thursday, May 4 |
| » Lost to White Sox (5-8), 2-1 | League Park II (2-2) | 6-8 | |
| » Starters: Ed Lopat vs Vern Kennedy | Fifth | 5½ out |
| Saturday, May 6 |
| » Defeated Browns (12-4), 3-2 | League Park II (3-2) | 7-8 | |
| » Starters: Bob Muncrief vs Hal Kleine | Fourth | 4½ out |
| Sunday, May 7 |
| » Lost to Browns (13-4), 7-4 | Cleveland Stadium (1-3) | 7-9 | |
| » Starters: Jack Kramer vs Al Smith | Fifth | 4½ out |
| » Defeated Browns (13-5), 3-2 | Cleveland Stadium (2-3) | 8-9 | |
| » Starters: Al Hollingsworth vs Allie Reynolds | Fifth | 4½ out |
| Wednesday, May 10 |
| » Defeated Red Sox (6-10), 5-4 | Fenway Park (1-0) | 9-9 | Won 2 |
| » Starters: Mel Harder vs Pinky Woods | Fourth | 3½ out |
| Thursday, May 11 |
| » Defeated Red Sox (6-11), 7-6 | Fenway Park (2-0) | 10-9 | Won 3 |
| » Starters: Allie Reynolds vs Joe Bowman | Fourth | 2 out |
| Friday, May 12 |
| » Lost to Red Sox (7-11), 10-3 | Fenway Park (2-1) | 10-10 | |
| » Starters: Vern Kennedy vs Tex Hughson | Fourth | 3½ out |
| Saturday, May 13 |
| » Lost to Yankees (11-6), 5-1 | Yankee Stadium (0-1) | 10-11 | Lost 2 |
| » Starters: Hal Kleine vs Joe Page | Fourth | 3 out |
| Sunday, May 14 |
| » Lost to Yankees (12-6), 4-3 | Yankee Stadium (0-2) | 10-12 | Lost 3 |
| » Starters: Al Smith vs Tiny Bonham | Sixth | 5 out |
| » Lost to Yankees (13-6), 8-4 | Yankee Stadium (0-3) | 10-13 | Lost 4 |
| » Starters: Ray Poat vs Atley Donald | Sixth | 5 out |
| Monday, May 15 |
| » Lost to Senators (13-9), 4-3 | Griffith Stadium (0-1) | 10-14 | Lost 5 |
| » Starters: Mel Harder vs Johnny Niggeling | Sixth | 6 out |
| Tuesday, May 16 |
| » Lost to Senators (14-9), 3-2 | Griffith Stadium (0-2) | 10-15 | Lost 6 |
| » Starters: Allie Reynolds vs Mickey Haefner | Sixth | 6 out |
| Wednesday, May 17 |
| » Defeated Senators (14-10), 4-2 | Griffith Stadium (1-2) | 11-15 | |
| » Starters: Vern Kennedy vs Roger Wolff | Sixth | 5 out |
| Thursday, May 18 |
| » Lost to Senators (15-10), 4-2 | Griffith Stadium (1-3) | 11-16 | |
| » Starters: Hal Kleine vs Dutch Leonard | Sixth | 5 out |
| Friday, May 19 |
| » Defeated Athletics (13-13), 9-1 | Shibe Park (1-0) | 12-16 | |
| » Starters: Al Smith vs Luke Hamlin | Sixth | 4½ out |
| Saturday, May 20 |
| » Defeated Athletics (13-14), 5-0 | Shibe Park (2-0) | 13-16 | Won 2 |
| » Starters: Mel Harder vs Lum Harris | Sixth | 4 out |
| Sunday, May 21 |
| » Defeated Athletics (13-15), 5-4 | Shibe Park (3-0) | 14-16 | Won 3 |
| » Starters: Allie Reynolds vs Bobo Newsom | Sixth | 5 out |
| » Lost to Athletics (14-15), 3-2 | Shibe Park (3-1) | 14-17 | |
| » Starters: Steve Gromek vs Jesse Flores | Sixth | 5 out |
| Wednesday, May 24 |
| » Lost to Senators (16-14), 5-4 | League Park II (3-3) | 14-18 | Lost 2 |
| » Starters: Dutch Leonard vs Al Smith | Seventh | 5½ out |
| Thursday, May 25 |
| » Lost to Senators (17-14), 4-2 | Cleveland Stadium (2-4) | 14-19 | Lost 3 |
| » Starters: Mickey Haefner vs Mel Harder | Eighth | 6 out |
| Friday, May 26 |
| » Lost to Senators (18-14), 5-3 | League Park II (3-4) | 14-20 | Lost 4 |
| » Starters: Early Wynn vs Vern Kennedy | Eighth | 7 out |
| Saturday, May 27 |
| » Defeated Senators (18-15), 5-4 | League Park II (4-4) | 15-20 | |
| » Starters: Roger Wolff vs Hal Kleine | Eighth | 6 out |
| Sunday, May 28 |
| » Lost to Athletics (18-16), 4-3 | Cleveland Stadium (2-5) | 15-21 | |
| » Starters: Jesse Flores vs Steve Gromek | Seventh | 7 out |
| » Defeated Athletics (18-17), 5-3 | Cleveland Stadium (3-5) | 16-21 | |
| » Starters: Don Black vs Paul Calvert | Seventh | 7 out |
| Monday, May 29 |
| » Lost to Athletics (19-17), 9-4 | League Park II (4-5) | 16-22 | |
| » Starters: Luke Hamlin vs Ray Poat | Sixth | 7 out |
| Tuesday, May 30 |
| » Defeated Red Sox (18-19), 9-3 | Cleveland Stadium (4-5) | 17-22 | |
| » Starters: Emmett O'Neill vs Mel Harder | Sixth | 5 out |
| » Defeated Red Sox (18-20), 4-3 | Cleveland Stadium (5-5) | 18-22 | Won 2 |
| » Starters: Yank Terry vs Allie Reynolds | Sixth | 5 out |
| Wednesday, May 31 |
| » Defeated Red Sox (18-21), 7-4 | League Park II (5-5) | 19-22 | Won 3 |
| » Starters: Oscar Judd vs Vern Kennedy | Sixth | 4½ out |
| Thursday, June 1 |
| » Lost to Red Sox (19-21), 7-6 | League Park II (5-6) | 19-23 | |
| » Starters: Vic Johnson vs Hal Kleine | Seventh | 4½ out |
| Friday, June 2 |
| » Lost to Yankees (21-16), 5-1 | Cleveland Stadium (5-6) | 19-24 | Lost 2 |
| » Starters: Hank Borowy vs Paul Calvert | Eighth | 5½ out |
| Saturday, June 3 |
| » Defeated Yankees (21-17), 5-4 | League Park II (6-6) | 20-24 | |
| » Starters: Tiny Bonham vs Al Smith | Seventh | 5½ out |
| Sunday, June 4 |
| » Lost to Yankees (22-17), 6-4 | Cleveland Stadium (5-7) | 20-25 | |
| » Starters: Joe Page vs Mel Harder | Seventh | 5½ out |
| » Defeated Yankees (22-18), 4-3 | Cleveland Stadium (6-7) | 21-25 | |
| » Starters: Monk Dubiel vs Allie Reynolds | Seventh | 5½ out |
| Thursday, June 8 |
| » Defeated Browns (27-21), 4-3 | Sportsman's Park III (1-2) | 22-25 | Won 2 |
| » Starters: Al Smith vs Jack Kramer | Sixth | 4½ out |
| Friday, June 9 |
| » Defeated Browns (27-22), 4-2 | Sportsman's Park III (2-2) | 23-25 | Won 3 |
| » Starters: Allie Reynolds vs Nels Potter | Sixth | 3½ out |
| Sunday, June 11 |
| » Defeated Browns (27-23), 13-1 | Sportsman's Park III (3-2) | 24-25 | Won 4 |
| » Starters: Mel Harder vs Denny Galehouse | Fifth | 3½ out |
| » Lost to Browns (28-23), 4-2 | Sportsman's Park III (3-3) | 24-26 | |
| » Starters: Steve Gromek vs Bob Muncrief | Fifth | 3½ out |
| Monday, June 12 |
| » Defeated Tigers (25-25), 6-5 | Cleveland Stadium (7-7) | 25-26 | |
| » Starters: Johnny Gorsica vs Paul Calvert | Fifth | 3 out |
| Wednesday, June 14 |
| » Lost to Tigers (26-25), 3-0 | League Park II (6-7) | 25-27 | |
| » Starters: Rufe Gentry vs Al Smith | Sixth | 5 out |
| » Lost to Tigers (27-25), 11-3 | League Park II (6-8) | 25-28 | Lost 2 |
| » Starters: Hal Newhouser vs Vern Kennedy | Sixth | 5 out |
| Thursday, June 15 |
| » Defeated Tigers (27-26), 3-2 | League Park II (7-8) | 26-28 | |
| » Starters: Dizzy Trout vs Allie Reynolds | Fifth | 4½ out |
| Friday, June 16 |
| » Lost to White Sox (23-24), 3-1 | Cleveland Stadium (7-8) | 26-29 | |
| » Starters: Orval Grove vs Mel Harder | Seventh | 5½ out |
| Sunday, June 18 |
| » Lost to White Sox (24-24), 3-2 | Cleveland Stadium (7-9) | 26-30 | Lost 2 |
| » Starters: Bill Dietrich vs Ed Klieman | Seventh | 6 out |
| » Lost to White Sox (25-24), 7-6 | Cleveland Stadium (7-10) | 26-31 | Lost 3 |
| » Starters: Thornton Lee vs Vern Kennedy | Seventh | 6 out |
| Tuesday, June 20 |
| » Defeated Tigers (29-29), 3-1 | Tiger Stadium (4-1) | 27-31 | |
| » Starters: Allie Reynolds vs Dizzy Trout | Seventh | 5½ out |
| Future Indian Dave Nelson is born in Fort Sill, OK. |
| Wednesday, June 21 |
| » Defeated Tigers (29-30), 9-7 | Tiger Stadium (5-1) | 28-31 | Won 2 |
| » Starters: Mel Harder vs Johnny Gorsica | Seventh | 5½ out |
| Thursday, June 22 |
| » Lost to Tigers (30-30), 4-3 | Tiger Stadium (5-2) | 28-32 | |
| » Starters: Vern Kennedy vs Rufe Gentry | Seventh | 5½ out |
| Friday, June 23 |
| » Defeated White Sox (27-27), 5-1 | Comiskey Park I (1-1) | 29-32 | |
| » Starters: Al Smith vs Thornton Lee | Sixth | 5½ out |
| Saturday, June 24 |
| » Lost to White Sox (28-27), 2-1 | Comiskey Park I (1-2) | 29-33 | |
| » Starters: Allie Reynolds vs Orval Grove | Seventh | 6½ out |
| Sunday, June 25 |
| » Lost to White Sox (29-27), 11-0 | Comiskey Park I (1-3) | 29-34 | Lost 2 |
| » Starters: Mel Harder vs Bill Dietrich | Eighth | 8½ out |
| » Lost to White Sox (30-27), 4-3 | Comiskey Park I (1-4) | 29-35 | Lost 3 |
| » Starters: Ed Klieman vs Ed Lopat | Eighth | 8½ out |
| Wednesday, June 28 |
| » Lost to Athletics (30-34), 7-3 | Shibe Park (3-2) | 29-36 | Lost 4 |
| » Starters: Vern Kennedy vs Don Black | Eighth | 8½ out |
| Thursday, June 29 |
| » Defeated Athletics (30-35), 6-0 | Shibe Park (4-2) | 30-36 | |
| » Starters: Allie Reynolds vs Russ Christopher | Eighth | 7½ out |
| Friday, June 30 |
| » Defeated Athletics (30-36), 5-4 | Shibe Park (5-2) | 31-36 | Won 2 |
| » Starters: Al Smith vs Bobo Newsom | Sixth | 7½ out |
| Saturday, July 1 |
| » Lost to Senators (33-34), 4-2 | Griffith Stadium (1-4) | 31-37 | |
| » Starters: Mel Harder vs Dutch Leonard | Seventh | 8½ out |
| Sunday, July 2 |
| » Defeated Senators (33-35), 4-3 | Griffith Stadium (2-4) | 32-37 | |
| » Starters: Ed Klieman vs Mickey Haefner | Sixth | 6½ out |
| » Defeated Senators (33-36), 6-3 | Griffith Stadium (3-4) | 33-37 | Won 2 |
| » Starters: Steve Gromek vs Bill LeFebvre | Sixth | 6½ out |
| Tuesday, July 4 |
| » Defeated Yankees (34-33), 3-1 | Yankee Stadium (1-3) | 34-37 | Won 3 |
| » Starters: Allie Reynolds vs Monk Dubiel | Fifth | 5½ out |
| » Defeated Yankees (34-34), 7-2 | Yankee Stadium (2-3) | 35-37 | Won 4 |
| » Starters: Ray Poat vs Joe Page | Fifth | 5½ out |
| » Major-league debuts: Russ Derry (Yankees) |
| Wednesday, July 5 |
| » Lost to Yankees (35-34), 6-2 | Yankee Stadium (2-4) | 35-38 | |
| » Starters: Al Smith vs Atley Donald | Sixth | 6½ out |
| Thursday, July 6 |
| » Lost to Yankees (36-34), 4-0 | Yankee Stadium (2-5) | 35-39 | Lost 2 |
| » Starters: Mel Harder vs Hank Borowy | Sixth | 7½ out |
| Friday, July 7 |
| » Defeated Red Sox (40-35), 8-5 | Fenway Park (3-1) | 36-39 | |
| » Starters: Steve Gromek vs Pinky Woods | Sixth | 6½ out |
| Saturday, July 8 |
| » Lost to Red Sox (41-35), 11-7 | Fenway Park (3-2) | 36-40 | |
| » Starters: Allie Reynolds vs Yank Terry | Sixth | 7½ out |
| Sunday, July 9 |
| » Defeated Red Sox (41-36), 8-2 | Fenway Park (4-2) | 37-40 | |
| » Starters: Ed Klieman vs Clem Hausmann | Sixth | 7½ out |
| » Lost to Red Sox (42-36), 4-2 | Fenway Park (4-3) | 37-41 | |
| » Starters: Ray Poat vs Joe Bowman | Sixth | 7½ out |
| Thursday, July 13 |
| » Defeated Browns (45-35), 6-5 | Cleveland Stadium (8-10) | 38-41 | |
| » Starters: Sig Jakucki vs Allie Reynolds | Fifth | 7½ out |
| » Lost to Browns (46-35), 4-1 | Cleveland Stadium (8-11) | 38-42 | |
| » Starters: Nels Potter vs Al Smith | Fifth | 7½ out |
| Friday, July 14 |
| » Defeated Browns (46-36), 3-2 | League Park II (8-8) | 39-42 | |
| » Starters: Bob Muncrief vs Steve Gromek | Fifth | 6½ out |
| Saturday, July 15 |
| » Defeated Browns (46-37), 13-2 | League Park II (9-8) | 40-42 | Won 2 |
| » Starters: Al Hollingsworth vs Ed Klieman | Fifth | 5½ out |
| Sunday, July 16 |
| » Lost to Browns (47-37), 8-7 | Cleveland Stadium (8-12) | 40-43 | |
| » Starters: Tex Shirley vs Ray Poat | Fifth | 7½ out |
| » Lost to Browns (48-37), 2-1 | Cleveland Stadium (8-13) | 40-44 | Lost 2 |
| » Starters: Jack Kramer vs Allie Reynolds | Fifth | 7½ out |
| Tuesday, July 18 |
| » Defeated Athletics (37-46), 4-3 | Cleveland Stadium (9-13) | 41-44 | |
| » Starters: Don Black vs Al Smith | Fifth | 7½ out |
| Wednesday, July 19 |
| » Defeated Athletics (37-47), 7-1 | League Park II (10-8) | 42-44 | Won 2 |
| » Starters: Bobo Newsom vs Ed Klieman | Fifth | 6½ out |
| Thursday, July 20 |
| » Defeated Athletics (37-48), 2-1 | League Park II (11-8) | 43-44 | Won 3 |
| » Starters: Lum Harris vs Steve Gromek | Fourth | 6½ out |
| Friday, July 21 |
| » Defeated Athletics (37-49), 4-1 | Cleveland Stadium (10-13) | 44-44 | Won 4 |
| » Starters: Luke Hamlin vs Jim Bagby | Fourth | 5½ out |
| Saturday, July 22 |
| » Lost to Senators (42-45), 9-6 | League Park II (11-9) | 44-45 | |
| » Starters: Mickey Haefner vs Allie Reynolds | Fifth | 5½ out |
| Sunday, July 23 |
| » Defeated Senators (42-46), 4-3 | Cleveland Stadium (11-13) | 45-45 | |
| » Starters: Dutch Leonard vs Al Smith | Fourth | 4½ out |
| » Defeated Senators (42-47), 9-5 | Cleveland Stadium (12-13) | 46-45 | Won 2 |
| » Starters: Milo Candini vs Mel Harder | Fourth | 4½ out |
| Monday, July 24 |
| » Defeated Senators (42-48), 10-1 | League Park II (12-9) | 47-45 | Won 3 |
| » Starters: Early Wynn vs Ed Klieman | Fourth | 4½ out |
| Tuesday, July 25 |
| » Defeated Yankees (47-42), 10-0 | Cleveland Stadium (13-13) | 48-45 | Won 4 |
| » Starters: Hank Borowy vs Steve Gromek | Fourth | 4½ out |
| Future Indian Buddy Bradford is born in Mobile, AL. |
| Wednesday, July 26 |
| » Lost to Yankees (48-42), 6-3 | Cleveland Stadium (13-14) | 48-46 | |
| » Starters: Atley Donald vs Jim Bagby | Fourth | 5½ out |
| Thursday, July 27 |
| » Defeated Yankees (48-43), 8-1 | League Park II (13-9) | 49-46 | |
| » Starters: Monk Dubiel vs Allie Reynolds | Fourth | 4½ out |
| Friday, July 28 |
| » Lost to Yankees (49-43), 13-7 | League Park II (13-10) | 49-47 | |
| » Starters: Tiny Bonham vs Al Smith | Fourth | 5½ out |
| Sunday, July 30 |
| » Lost to Red Sox (51-44), 5-3 | Cleveland Stadium (13-15) | 49-48 | Lost 2 |
| » Starters: Yank Terry vs Ed Klieman | Fourth | 6½ out |
| » Defeated Red Sox (51-45), 3-2 | Cleveland Stadium (14-15) | 50-48 | |
| » Starters: Pinky Woods vs Mel Harder | Fourth | 6½ out |
| Future Indian Pat Kelly is born in Philadelphia, PA. |
| Monday, July 31 |
| » Lost to Red Sox (52-45), 1-0 | Cleveland Stadium (14-16) | 50-49 | |
| » Starters: Mike Ryba vs Steve Gromek | Fourth | 7½ out |
| Tuesday, August 1 |
| » Defeated Red Sox (52-46), 8-4 | League Park II (14-10) | 51-49 | |
| » Starters: Tex Hughson vs Jim Bagby | Fourth | 7½ out |
| Thursday, August 3 |
| » Lost to White Sox (48-50), 3-2 | Comiskey Park I (1-5) | 51-50 | |
| » Starters: Al Smith vs Bill Dietrich | Fourth | 8½ out |
| » Lost to White Sox (49-50), 5-1 | Comiskey Park I (1-6) | 51-51 | Lost 2 |
| » Starters: Allie Reynolds vs Orval Grove | Fourth | 8½ out |
| Friday, August 4 |
| » Lost to White Sox (50-50), 5-3 | Comiskey Park I (1-7) | 51-52 | Lost 3 |
| » Starters: Mel Harder vs Buck Ross | Sixth | 9 out |
| Saturday, August 5 |
| » Lost to Browns (60-42), 9-6 | Sportsman's Park III (3-4) | 51-53 | Lost 4 |
| » Starters: Ed Klieman vs Bob Muncrief | Sixth | 10 out |
| Sunday, August 6 |
| » Lost to Browns (61-42), 9-6 | Sportsman's Park III (3-5) | 51-54 | Lost 5 |
| » Starters: Jim Bagby vs Denny Galehouse | Sixth | 12 out |
| » Lost to Browns (62-42), 6-4 | Sportsman's Park III (3-6) | 51-55 | Lost 6 |
| » Starters: Steve Gromek vs Nels Potter | Sixth | 12 out |
| Wednesday, August 9 |
| » Defeated Athletics (47-60), 4-3 | Shibe Park (6-2) | 52-55 | |
| » Starters: Al Smith vs Bobo Newsom | Fifth | 12 out |
| Thursday, August 10 |
| » Defeated Athletics (47-61), 5-4 | Shibe Park (7-2) | 53-55 | Won 2 |
| » Starters: Steve Gromek vs Luke Hamlin | Fifth | 12 out |
| Friday, August 11 |
| » Lost to Athletics (48-61), 6-3 | Shibe Park (7-3) | 53-56 | |
| » Starters: Mel Harder vs Russ Christopher | Fifth | 12 out |
| Saturday, August 12 |
| » Lost to Athletics (49-61), 4-3 | Shibe Park (7-4) | 53-57 | Lost 2 |
| » Starters: Ed Klieman vs Lum Harris | Fifth | 13 out |
| Sunday, August 13 |
| » Lost to Senators (45-63), 2-1 | Griffith Stadium (3-5) | 53-58 | Lost 3 |
| » Starters: Jim Bagby vs Mickey Haefner | Sixth | 14 out |
| » Lost to Senators (46-63), 4-1 | Griffith Stadium (3-6) | 53-59 | Lost 4 |
| » Starters: Ray Poat vs Early Wynn | Sixth | 14 out |
| Monday, August 14 |
| » Lost to Senators (47-63), 8-5 | Griffith Stadium (3-7) | 53-60 | Lost 5 |
| » Starters: Steve Gromek vs Roger Wolff | Sixth | 14 out |
| Tuesday, August 15 |
| » Defeated Senators (47-64), 1-0 | Griffith Stadium (4-7) | 54-60 | |
| » Starters: Al Smith vs Dutch Leonard | Fifth | 14 out |
| Wednesday, August 16 |
| » Lost to Yankees (58-52), 11-8 | Yankee Stadium (2-6) | 54-61 | |
| » Starters: Ed Klieman vs Atley Donald | Sixth | 14 out |
| Thursday, August 17 |
| » Lost to Yankees (59-52), 10-3 | Yankee Stadium (2-7) | 54-62 | Lost 2 |
| » Starters: Jim Bagby vs Monk Dubiel | Fifth | 15 out |
| Friday, August 18 |
| » Defeated Yankees (59-53), 2-0 | Yankee Stadium (3-7) | 55-62 | |
| » Starters: Mel Harder vs Mel Queen | Sixth | 14 out |
| Saturday, August 19 |
| » Lost to Yankees (60-53), 9-3 | Yankee Stadium (3-8) | 55-63 | |
| » Starters: Steve Gromek vs Tiny Bonham | Sixth | 14 out |
| Sunday, August 20 |
| » Lost to Red Sox (63-53), 8-6 | Fenway Park (4-4) | 55-64 | Lost 2 |
| » Starters: Al Smith vs Yank Terry | Sixth | 14 out |
| » Lost to Red Sox (64-53), 11-4 | Fenway Park (4-5) | 55-65 | Lost 3 |
| » Starters: Ed Klieman vs Rex Cecil | Sixth | 14 out |
| Future Indian Graig Nettles is born in San Diego, CA. |
| Monday, August 21 |
| » Defeated Red Sox (64-54), 7-6 | Fenway Park (5-5) | 56-65 | |
| » Starters: Jim Bagby vs Oscar Judd | Sixth | 14 out |
| Tuesday, August 22 |
| » Defeated Red Sox (64-55), 5-3 | Fenway Park (6-5) | 57-65 | Won 2 |
| » Starters: Steve Gromek vs Emmett O'Neill | Sixth | 13 out |
| Friday, August 25 |
| » Defeated White Sox (56-64), 10-2 | Cleveland Stadium (15-16) | 58-65 | Won 3 |
| » Starters: Bill Dietrich vs Mel Harder | Sixth | 12 out |
| Saturday, August 26 |
| » Lost to White Sox (57-64), 6-5 | League Park II (14-11) | 58-66 | |
| » Starters: Ed Lopat vs Al Smith | Seventh | 12 out |
| Sunday, August 27 |
| » Defeated White Sox (57-65), 4-3 | Cleveland Stadium (16-16) | 59-66 | |
| » Starters: Joe Haynes vs Jim Bagby | Fifth | 11 out |
| » Defeated White Sox (57-66), 1-0 | Cleveland Stadium (17-16) | 60-66 | Won 2 |
| » Starters: Johnny Humphries vs Steve Gromek | Fifth | 11 out |
| Tuesday, August 29 |
| » Lost to Browns (71-54), 8-3 | Cleveland Stadium (17-17) | 60-67 | |
| » Starters: Denny Galehouse vs Ed Klieman | Sixth | 12 out |
| Wednesday, August 30 |
| » Defeated Browns (71-55), 12-7 | League Park II (15-11) | 61-67 | |
| » Starters: Jack Kramer vs Mel Harder | Fifth | 11 out |
| Friday, September 1 |
| » Lost to White Sox (59-67), 5-4 | Comiskey Park I (1-8) | 61-68 | |
| » Starters: Al Smith vs Joe Haynes | Fifth | 10½ out |
| Saturday, September 2 |
| » Defeated White Sox (59-68), 5-2 | Comiskey Park I (2-8) | 62-68 | |
| » Starters: Jim Bagby vs Johnny Humphries | Fifth | 9½ out |
| Sunday, September 3 |
| » Defeated White Sox (59-69), 4-1 | Comiskey Park I (3-8) | 63-68 | Won 2 |
| » Starters: Steve Gromek vs Bill Dietrich | Fifth | 9½ out |
| Monday, September 4 |
| » Defeated Browns (72-59), 6-4 | Sportsman's Park III (4-6) | 64-68 | Won 3 |
| » Starters: Mel Harder vs Sig Jakucki | Fifth | 10 out |
| » Lost to Browns (73-59), 5-1 | Sportsman's Park III (4-7) | 64-69 | |
| » Starters: Ed Klieman vs Nels Potter | Fifth | 10 out |
| Thursday, September 7 |
| » Lost to Tigers (73-60), 3-0 | Tiger Stadium (5-3) | 64-70 | Lost 2 |
| » Starters: Jim Bagby vs Dizzy Trout | Fourth | 10½ out |
| Saturday, September 9 |
| » Lost to Tigers (74-60), 15-6 | Tiger Stadium (5-4) | 64-71 | Lost 3 |
| » Starters: Ed Klieman vs Stubby Overmire | Fifth | 11 out |
| Sunday, September 10 |
| » Lost to Tigers (75-60), 5-0 | Tiger Stadium (5-5) | 64-72 | Lost 4 |
| » Starters: Mel Harder vs Hal Newhouser | Fifth | 11 out |
| » Defeated Tigers (75-61), 7-4 | Tiger Stadium (6-5) | 65-72 | |
| » Starters: Steve Gromek vs Dizzy Trout | Fifth | 11 out |
| Friday, September 15 |
| » Defeated Tigers (75-62), 4-3 | Cleveland Stadium (18-17) | 66-72 | Won 2 |
| » Starters: Dizzy Trout vs Steve Gromek | Fourth | 11 out |
| » Lost to Tigers (76-62), 9-1 | Cleveland Stadium (18-18) | 66-73 | |
| » Starters: Hal Newhouser vs Mel Harder | Fourth | 11 out |
| Sunday, September 17 |
| » Lost to Tigers (77-62), 7-2 | Cleveland Stadium (18-19) | 66-74 | Lost 2 |
| » Starters: Stubby Overmire vs Al Smith | Sixth | 12½ out |
| » Lost to Tigers (78-62), 3-0 | Cleveland Stadium (18-20) | 66-75 | Lost 3 |
| » Starters: Rufe Gentry vs Ed Klieman | Sixth | 12½ out |
| Tuesday, September 19 |
| » Defeated Red Sox (74-67), 8-2 | Cleveland Stadium (19-20) | 67-75 | |
| » Starters: Rex Cecil vs Steve Gromek | Fifth | 12½ out |
| Wednesday, September 20 |
| » Defeated Red Sox (74-68), 11-10 | League Park II (16-11) | 68-75 | Won 2 |
| » Starters: Clem Dreisewerd vs Mel Harder | Fifth | 12½ out |
| Thursday, September 21 |
| » Defeated Red Sox (74-69), 5-2 | League Park II (17-11) | 69-75 | Won 3 |
| » Starters: Mike Ryba vs Ed Klieman | Fifth | 11½ out |
| Friday, September 22 |
| » Lost to Yankees (78-66), 7-3 | Cleveland Stadium (19-21) | 69-76 | |
| » Starters: Tiny Bonham vs Al Smith | Fifth | 13 out |
| Saturday, September 23 |
| » Lost to Yankees (79-66), 7-2 | League Park II (17-12) | 69-77 | Lost 2 |
| » Starters: Bill Bevens vs Steve Gromek | Fifth | 14 out |
| » Major-league debuts: Earl Henry (Indians) |
| Sunday, September 24 |
| » Defeated Yankees (79-67), 4-1 | Cleveland Stadium (20-21) | 70-77 | |
| » Starters: Hank Borowy vs Mel Harder | Fifth | 14 out |
| Monday, September 25 |
| » Defeated Senators (61-87), 6-0 | Cleveland Stadium (21-21) | 71-77 | Won 2 |
| » Starters: Mickey Haefner vs Ed Klieman | Fourth | 13 out |
| Tuesday, September 26 |
| » Lost to Senators (62-87), 8-3 | League Park II (17-13) | 71-78 | |
| » Starters: Dutch Leonard vs Al Smith | Fourth | 14 out |
| Wednesday, September 27 |
| » Defeated Senators (62-88), 6-4 | League Park II (18-13) | 72-78 | |
| » Starters: Baby Ortiz vs Earl Henry | Fifth | 14 out |
| Friday, September 29 |
| » Lost to Athletics (69-82), 4-2 | League Park II (18-14) | 72-79 | |
| » Starters: Don Black vs Bill Bonness | Fourth | 14½ out |
| » Tied Athletics, 1-1 | League Park II (18-14) | 72-79 | |
| » Starters: Jesse Flores vs Steve Gromek | Fourth | 14½ out |
| Saturday, September 30 |
| » Lost to Athletics (70-82), 5-1 | League Park II (18-15) | 72-80 | Lost 2 |
| » Starters: Russ Christopher vs Joe Heving | Fourth | 15½ out |
| Sunday, October 1 |
| » Lost to Athletics (71-82), 5-2 | Cleveland Stadium (21-22) | 72-81 | Lost 3 |
| » Starters: Bobo Newsom vs Earl Henry | Fifth | 17 out |
| » Lost to Athletics (72-82), 5-0 | Cleveland Stadium (21-23) | 72-82 | Lost 4 |
| » Starters: Don Black vs Mel Harder | Fifth | 17 out |
| Tuesday, October 24 |
| Future Indian John Jeter is born in Shreveport, LA. |
| Sunday, October 29 |
| Future Indian Jim Bibby is born in Franklinton, NC. |
| Wednesday, December 6 |
| Future Indian Tony Horton is born in Santa Monica, CA. |
| Saturday, December 9 |
| Future Indian Del Unser is born in Decatur, IL. |
| Tuesday, December 19 |
| Future Indian Rob Gardner is born in Binghamton, NY. |
| Friday, December 22 |
| Future Indian Steve Carlton is born in Miami, FL. |
| Thursday, December 28 |
| Future Indian Ray Lamb is born in Glendale, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |
