| Sunday, February 21 |
| Future Senator Joe Foy is born in New York, NY. |
| Sunday, March 14 |
| Former Senator Earl Smith dies in Portsmouth, OH at the age of 53. |
| Tuesday, March 16 |
| Future Senator Rick Reichardt is born in Madison, WI. |
| Tuesday, March 23 |
| Future Senator Bruce Howard is born in Salisbury, MD. |
| Saturday, April 3 |
| Future Senator Barry Moore is born in Statesville, NC. |
| Sunday, April 4 |
| Future Senator Mike Epstein is born in Bronx, NY. |
| Tuesday, April 20 |
| » Defeated Athletics (0-1), 7-5 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Lum Harris vs Dutch Leonard | First | -- |
| Thursday, April 22 |
| » Lost to Yankees (1-0), 5-4 | Yankee Stadium (0-1) | 1-1 | |
| » Starters: Early Wynn vs Tiny Bonham | Second | ½ out |
| » Major-league debuts: Billy Johnson and Snuffy Stirnweiss (Yankees) Mickey Haefner (Senators) |
| Saturday, April 24 |
| » Lost to Yankees (2-0), 1-0 | Yankee Stadium (0-2) | 1-2 | Lost 2 |
| » Starters: Ewald Pyle vs Spud Chandler | Fifth | 1½ out |
| Sunday, April 25 |
| » Defeated Athletics (2-3), 12-2 | Shibe Park (1-0) | 2-2 | |
| » Starters: Dutch Leonard vs Lum Harris | Third | 1 out |
| » Defeated Athletics (2-4), 5-0 | Shibe Park (2-0) | 3-2 | Won 2 |
| » Starters: Alex Carrasquel vs John Burrows | Third | 1 out |
| Tuesday, April 27 |
| » Lost to Athletics (3-4), 2-1 | Griffith Stadium (1-1) | 3-3 | |
| » Starters: Jesse Flores vs Early Wynn | Fourth | 1 out |
| Wednesday, April 28 |
| » Defeated Athletics (3-5), 3-0 | Griffith Stadium (2-1) | 4-3 | |
| » Starters: Russ Christopher vs Ewald Pyle | Third | 1 out |
| Thursday, April 29 |
| » Defeated Athletics (3-6), 5-1 | Griffith Stadium (3-1) | 5-3 | Won 2 |
| » Starters: Don Black vs Mickey Haefner | Third | 1 out |
| Friday, April 30 |
| » Defeated Yankees (5-2), 2-1 | Griffith Stadium (4-1) | 6-3 | Won 3 |
| » Starters: Hank Borowy vs Dutch Leonard | Second | 1 out |
| Saturday, May 1 |
| » Lost to Yankees (6-2), 9-7 | Griffith Stadium (4-2) | 6-4 | |
| » Starters: Bill Zuber vs Alex Carrasquel | Third | 1 out |
| » Major-league debuts: Milo Candini (Senators) |
| Sunday, May 2 |
| » Lost to Yankees (7-2), 11-3 | Griffith Stadium (4-3) | 6-5 | Lost 2 |
| » Starters: Tiny Bonham vs Early Wynn | Third | 1 out |
| » Defeated Yankees (7-3), 4-1 | Griffith Stadium (5-3) | 7-5 | |
| » Starters: Butch Wensloff vs Ewald Pyle | Third | 1 out |
| » Major-league debuts: Butch Wensloff (Yankees) |
| Tuesday, May 4 |
| » Lost to Athletics (5-8), 3-1 | Shibe Park (2-1) | 7-6 | |
| » Starters: Dutch Leonard vs Jesse Flores | Fourth | 2 out |
| Wednesday, May 5 |
| » Defeated Athletics (5-9), 8-1 | Shibe Park (3-1) | 8-6 | |
| » Starters: Alex Carrasquel vs Lum Harris | Fourth | 2 out |
| Thursday, May 6 |
| » Lost to Athletics (6-9), 7-0 | Shibe Park (3-2) | 8-7 | |
| » Starters: Ewald Pyle vs Roger Wolff | Fourth | 3½ out |
| Friday, May 7 |
| » Lost to Red Sox (5-10), 3-2 | Griffith Stadium (5-4) | 8-8 | Lost 2 |
| » Starters: Yank Terry vs Early Wynn | Fourth | 4½ out |
| Saturday, May 8 |
| » Lost to Red Sox (6-10), 2-1 | Griffith Stadium (5-5) | 8-9 | Lost 3 |
| » Starters: Joe Dobson vs Jim Mertz | Fifth | 4½ out |
| Sunday, May 9 |
| » Defeated Red Sox (6-11), 3-2 | Griffith Stadium (6-5) | 9-9 | |
| » Starters: Tex Hughson vs Dutch Leonard | Fourth | 3½ out |
| » Defeated Red Sox (6-12), 8-2 | Griffith Stadium (7-5) | 10-9 | Won 2 |
| » Starters: Ken Chase vs Alex Carrasquel | Fourth | 3½ out |
| Wednesday, May 12 |
| » Lost to Indians (11-6), 8-2 | Cleveland Stadium (0-1) | 10-10 | |
| » Starters: Early Wynn vs Chubby Dean | Fifth | 3½ out |
| Thursday, May 13 |
| » Defeated Indians (11-7), 3-2 | League Park II (1-0) | 11-10 | |
| » Starters: Ewald Pyle vs Al Smith | Fourth | 3 out |
| Former Senator Jack Hendricks dies in Chicago, IL at the age of 69. |
| Friday, May 14 |
| » Defeated Indians (11-8), 3-1 | League Park II (2-0) | 12-10 | Won 2 |
| » Starters: Dutch Leonard vs Jim Bagby | Third | 2 out |
| Saturday, May 15 |
| » Lost to Tigers (10-9), 8-1 | Tiger Stadium (0-1) | 12-11 | |
| » Starters: Jim Mertz vs Dizzy Trout | Fourth | 2½ out |
| Sunday, May 16 |
| » Defeated Tigers (10-10), 7-1 | Tiger Stadium (1-1) | 13-11 | |
| » Starters: Early Wynn vs Virgil Trucks | Third | 1½ out |
| » Defeated Tigers (10-11), 10-6 | Tiger Stadium (2-1) | 14-11 | Won 2 |
| » Starters: Alex Carrasquel vs Stubby Overmire | Third | 1½ out |
| Friday, May 21 |
| » Lost to White Sox (9-11), 1-0 | Comiskey Park I (0-1) | 14-12 | |
| » Starters: Dutch Leonard vs Johnny Humphries | Third | 2 out |
| Saturday, May 22 |
| » Lost to White Sox (10-11), 5-2 | Comiskey Park I (0-2) | 14-13 | Lost 2 |
| » Starters: Ewald Pyle vs Eddie Smith | Fourth | 2 out |
| Sunday, May 23 |
| » Defeated White Sox (10-12), 11-0 | Comiskey Park I (1-2) | 15-13 | |
| » Starters: Early Wynn vs Buck Ross | Third | 1½ out |
| Wednesday, May 26 |
| » Defeated Browns (10-13), 1-0 | Griffith Stadium (8-5) | 16-13 | Won 2 |
| » Starters: Johnny Niggeling vs Dutch Leonard | Third | 1 out |
| Thursday, May 27 |
| » Defeated Browns (10-14), 4-2 | Griffith Stadium (9-5) | 17-13 | Won 3 |
| » Starters: Al Hollingsworth vs Early Wynn | First | -- |
| Saturday, May 29 |
| » Defeated White Sox (10-15), 7-4 | Griffith Stadium (10-5) | 18-13 | Won 4 |
| » Starters: Eddie Smith vs Alex Carrasquel | First | -- |
| Sunday, May 30 |
| » Lost to White Sox (11-15), 5-2 | Griffith Stadium (10-6) | 18-14 | |
| » Starters: Bill Dietrich vs Ewald Pyle | Second | 1½ out |
| » Lost to White Sox (12-15), 5-1 | Griffith Stadium (10-7) | 18-15 | Lost 2 |
| » Starters: Thornton Lee vs Lefty Gomez | Second | 1½ out |
| Monday, May 31 |
| » Defeated Indians (17-17), 8-7 | Griffith Stadium (11-7) | 19-15 | |
| » Starters: Jim Bagby vs Dutch Leonard | Second | 1½ out |
| » Lost to Indians (18-17), 7-6 | Griffith Stadium (11-8) | 19-16 | |
| » Starters: Al Milnar vs Early Wynn | Second | 1½ out |
| Future Senator Jackie Brown is born in Holdenville, OK. |
| Tuesday, June 1 |
| » Defeated Indians (18-18), 3-2 | Griffith Stadium (12-8) | 20-16 | |
| » Starters: Vern Kennedy vs Ewald Pyle | Second | 2 out |
| Wednesday, June 2 |
| » Defeated Indians (18-19), 13-1 | Griffith Stadium (13-8) | 21-16 | Won 2 |
| » Starters: Jack Salveson vs Milo Candini | Second | 2 out |
| Thursday, June 3 |
| » Lost to Tigers (19-16), 8-2 | Griffith Stadium (13-9) | 21-17 | |
| » Starters: Virgil Trucks vs Jim Mertz | Second | 2 out |
| Friday, June 4 |
| » Lost to Tigers (20-16), 2-1 | Griffith Stadium (13-10) | 21-18 | Lost 2 |
| » Starters: Tommy Bridges vs Dutch Leonard | Third | 2 out |
| Saturday, June 5 |
| » Defeated Tigers (20-17), 6-3 | Griffith Stadium (14-10) | 22-18 | |
| » Starters: Hal Newhouser vs Early Wynn | Second | 2 out |
| Sunday, June 6 |
| » Defeated Tigers (20-18), 5-1 | Griffith Stadium (15-10) | 23-18 | Won 2 |
| » Starters: Dizzy Trout vs Ewald Pyle | Second | 2 out |
| » Defeated Tigers (20-19), 8-4 | Griffith Stadium (16-10) | 24-18 | Won 3 |
| » Starters: Stubby Overmire vs Milo Candini | Second | 2 out |
| Wednesday, June 9 |
| » Lost to Red Sox (21-23), 3-2 | Fenway Park (0-1) | 24-19 | |
| » Starters: Dutch Leonard vs Tex Hughson | Second | 2½ out |
| Thursday, June 10 |
| » Lost to Red Sox (22-23), 2-0 | Fenway Park (0-2) | 24-20 | Lost 2 |
| » Starters: Early Wynn vs Oscar Judd | Second | 2½ out |
| Saturday, June 12 |
| » Defeated Red Sox (22-24), 1-0 | Fenway Park (1-2) | 25-20 | |
| » Starters: Milo Candini vs Yank Terry | Second | 3 out |
| Sunday, June 13 |
| » Defeated Red Sox (22-25), 16-5 | Fenway Park (2-2) | 26-20 | Won 2 |
| » Starters: Jim Mertz vs Lou Lucier | Second | 2 out |
| » Lost to Red Sox (23-25), 7-0 | Fenway Park (2-3) | 26-21 | |
| » Starters: Alex Carrasquel vs Tex Hughson | Second | 2 out |
| Monday, June 14 |
| » Lost to Yankees (27-17), 4-1 | Griffith Stadium (16-11) | 26-22 | Lost 2 |
| » Starters: Spud Chandler vs Ewald Pyle | Second | 3 out |
| Tuesday, June 15 |
| » Lost to Yankees (28-17), 9-5 | Griffith Stadium (16-12) | 26-23 | Lost 3 |
| » Starters: Butch Wensloff vs Dutch Leonard | Second | 4 out |
| Wednesday, June 16 |
| » Defeated Yankees (28-18), 8-3 | Griffith Stadium (17-12) | 27-23 | |
| » Starters: Tommy Byrne vs Early Wynn | Second | 3 out |
| Thursday, June 17 |
| » Lost to Yankees (29-18), 9-8 | Griffith Stadium (17-13) | 27-24 | |
| » Starters: Atley Donald vs Jim Mertz | Second | 4 out |
| Friday, June 18 |
| » Defeated Athletics (27-27), 4-2 | Shibe Park (4-2) | 28-24 | |
| » Starters: Milo Candini vs Lum Harris | Second | 3 out |
| Saturday, June 19 |
| » Defeated Athletics (27-28), 6-3 | Shibe Park (5-2) | 29-24 | Won 2 |
| » Starters: Alex Carrasquel vs Orie Arntzen | Second | 3 out |
| Sunday, June 20 |
| » Defeated Yankees (30-20), 5-3 | Yankee Stadium (1-2) | 30-24 | Won 3 |
| » Starters: Dutch Leonard vs Butch Wensloff | Second | 3 out |
| » Lost to Yankees (31-20), 7-6 | Yankee Stadium (1-3) | 30-25 | |
| » Starters: Mickey Haefner vs Atley Donald | Second | 3 out |
| Tuesday, June 22 |
| » Defeated Yankees (31-21), 3-2 | Yankee Stadium (2-3) | 31-25 | |
| » Starters: Early Wynn vs Hank Borowy | Second | 2 out |
| Wednesday, June 23 |
| » Defeated Yankees (31-22), 8-0 | Yankee Stadium (3-3) | 32-25 | Won 2 |
| » Starters: Milo Candini vs Spud Chandler | Second | 2 out |
| » Lost to Yankees (32-22), 4-0 | Yankee Stadium (3-4) | 32-26 | |
| » Starters: Alex Carrasquel vs Tiny Bonham | Second | 2 out |
| Friday, June 25 |
| » Lost to Athletics (29-32), 5-2 | Griffith Stadium (17-14) | 32-27 | Lost 2 |
| » Starters: Orie Arntzen vs Dutch Leonard | Second | 2½ out |
| Saturday, June 26 |
| » Defeated Athletics (29-33), 4-1 | Griffith Stadium (18-14) | 33-27 | |
| » Starters: Jesse Flores vs Early Wynn | Second | 2½ out |
| Sunday, June 27 |
| » Defeated Athletics (29-34), 9-0 | Griffith Stadium (19-14) | 34-27 | Won 2 |
| » Starters: Roger Wolff vs Alex Carrasquel | Second | 2½ out |
| » Lost to Athletics (30-34), 5-4 | Griffith Stadium (19-15) | 34-28 | |
| » Starters: Russ Christopher vs Milo Candini | Second | 2½ out |
| Wednesday, June 30 |
| » Lost to White Sox (28-30), 7-1 | Comiskey Park I (1-3) | 34-29 | Lost 2 |
| » Starters: Dutch Leonard vs Orval Grove | Second | 2½ out |
| Thursday, July 1 |
| » Lost to White Sox (29-30), 2-0 | Comiskey Park I (1-4) | 34-30 | Lost 3 |
| » Starters: Early Wynn vs Bill Dietrich | Second | 2½ out |
| Friday, July 2 |
| » Defeated White Sox (29-31), 3-2 | Comiskey Park I (2-4) | 35-30 | |
| » Starters: Milo Candini vs Johnny Humphries | Second | 2½ out |
| Saturday, July 3 |
| » Defeated Browns (29-32), 6-4 | Sportsman's Park III (1-0) | 36-30 | Won 2 |
| » Starters: Ray Scarborough vs Nels Potter | Second | 2 out |
| Sunday, July 4 |
| » Lost to Browns (30-32), 4-2 | Sportsman's Park III (1-1) | 36-31 | |
| » Starters: Jim Mertz vs Steve Sundra | Second | 2 out |
| » Lost to Browns (31-32), 10-3 | Sportsman's Park III (1-2) | 36-32 | Lost 2 |
| » Starters: Alex Carrasquel vs Al Hollingsworth | Second | 2 out |
| Monday, July 5 |
| » Lost to Tigers (33-31), 10-3 | Tiger Stadium (2-2) | 36-33 | Lost 3 |
| » Starters: Dutch Leonard vs Dizzy Trout | Second | 2 out |
| » Defeated Tigers (33-32), 6-4 | Tiger Stadium (3-2) | 37-33 | |
| » Starters: Early Wynn vs Hal White | Second | 2 out |
| Tuesday, July 6 |
| » Lost to Tigers (34-32), 4-3 | Tiger Stadium (3-3) | 37-34 | |
| » Starters: Milo Candini vs Tommy Bridges | Second | 3 out |
| Wednesday, July 7 |
| » Lost to Tigers (35-32), 9-1 | Tiger Stadium (3-4) | 37-35 | Lost 2 |
| » Starters: Alex Carrasquel vs Hal Newhouser | Fourth | 4 out |
| Thursday, July 8 |
| » Lost to Indians (34-35), 5-2 | League Park II (2-1) | 37-36 | Lost 3 |
| » Starters: Ewald Pyle vs Allie Reynolds | Fourth | 4 out |
| Friday, July 9 |
| » Defeated Indians (34-36), 1-0 | Cleveland Stadium (1-1) | 38-36 | |
| » Starters: Dutch Leonard vs Jim Bagby | Fourth | 3½ out |
| Saturday, July 10 |
| » Defeated Indians (34-37), 4-0 | Cleveland Stadium (2-1) | 39-36 | Won 2 |
| » Starters: Early Wynn vs Vern Kennedy | Third | 4 out |
| Sunday, July 11 |
| » Lost to Indians (35-37), 5-1 | Cleveland Stadium (2-2) | 39-37 | |
| » Starters: Milo Candini vs Al Smith | Third | 5 out |
| » Defeated Indians (35-38), 6-4 | Cleveland Stadium (3-2) | 40-37 | |
| » Starters: Ray Scarborough vs Allie Reynolds | Third | 5 out |
| Thursday, July 15 |
| » Defeated Red Sox (35-40), 4-3 | Griffith Stadium (20-15) | 41-37 | Won 2 |
| » Starters: Yank Terry vs Early Wynn | Second | 4½ out |
| Friday, July 16 |
| » Lost to Red Sox (36-40), 4-1 | Griffith Stadium (20-16) | 41-38 | |
| » Starters: Oscar Judd vs Milo Candini | Third | 5½ out |
| » Major-league debuts: Catfish Metkovich (Red Sox) |
| Saturday, July 17 |
| » Defeated Red Sox (36-41), 3-0 | Griffith Stadium (21-16) | 42-38 | |
| » Starters: Tex Hughson vs Dutch Leonard | Second | 5½ out |
| Sunday, July 18 |
| » Defeated Red Sox (36-42), 9-2 | Griffith Stadium (22-16) | 43-38 | Won 2 |
| » Starters: Dick Newsome vs Ray Scarborough | Second | 5½ out |
| » Defeated Red Sox (36-43), 5-4 | Griffith Stadium (23-16) | 44-38 | Won 3 |
| » Starters: Lou Lucier vs Early Wynn | Second | 5½ out |
| Wednesday, July 21 |
| » Defeated Tigers (40-38), 6-5 | Griffith Stadium (24-16) | 45-38 | Won 4 |
| » Starters: Hal Newhouser vs Milo Candini | Second | 4½ out |
| Thursday, July 22 |
| » Lost to Tigers (41-38), 7-5 | Griffith Stadium (24-17) | 45-39 | |
| » Starters: Roy Henshaw vs Dutch Leonard | Second | 6 out |
| » Lost to Tigers (42-38), 1-0 | Griffith Stadium (24-18) | 45-40 | Lost 2 |
| » Starters: Stubby Overmire vs Early Wynn | Second | 6 out |
| Friday, July 23 |
| » Lost to Tigers (43-38), 12-6 | Griffith Stadium (24-19) | 45-41 | Lost 3 |
| » Starters: Tommy Bridges vs Ray Scarborough | Third | 7 out |
| Saturday, July 24 |
| » Lost to Indians (41-41), 2-0 | Griffith Stadium (24-20) | 45-42 | Lost 4 |
| » Starters: Allie Reynolds vs Mickey Haefner | Third | 7½ out |
| Sunday, July 25 |
| » Lost to Indians (42-41), 8-2 | Griffith Stadium (24-21) | 45-43 | Lost 5 |
| » Starters: Vern Kennedy vs Milo Candini | Third | 7½ out |
| » Defeated Indians (42-42), 7-2 | Griffith Stadium (25-21) | 46-43 | |
| » Starters: Ray Poat vs Jim Mertz | Third | 7½ out |
| Monday, July 26 |
| » Lost to Indians (43-42), 7-3 | Griffith Stadium (25-22) | 46-44 | |
| » Starters: Jim Bagby vs Early Wynn | Third | 8½ out |
| Tuesday, July 27 |
| » Lost to White Sox (43-43), 6-5 | Griffith Stadium (25-23) | 46-45 | Lost 2 |
| » Starters: Johnny Humphries vs Dutch Leonard | Third | 9½ out |
| Wednesday, July 28 |
| » Lost to White Sox (44-43), 12-7 | Griffith Stadium (25-24) | 46-46 | Lost 3 |
| » Starters: Buck Ross vs Ray Scarborough | Third | 9½ out |
| Thursday, July 29 |
| » Lost to White Sox (45-43), 5-4 | Griffith Stadium (25-25) | 46-47 | Lost 4 |
| » Starters: Eddie Smith vs Mickey Haefner | Fifth | 10½ out |
| Friday, July 30 |
| » Defeated White Sox (45-44), 4-1 | Griffith Stadium (26-25) | 47-47 | |
| » Starters: Thornton Lee vs Early Wynn | Third | 10½ out |
| Saturday, July 31 |
| » Defeated Browns (42-46), 14-7 | Griffith Stadium (27-25) | 48-47 | Won 2 |
| » Starters: Johnny Niggeling vs Dutch Leonard | Fourth | 9½ out |
| Sunday, August 1 |
| » Defeated Browns (42-47), 5-3 | Griffith Stadium (28-25) | 49-47 | Won 3 |
| » Starters: Bob Muncrief vs Ray Scarborough | Third | 9½ out |
| » Defeated Browns (42-48), 20-6 | Griffith Stadium (29-25) | 50-47 | Won 4 |
| » Starters: Steve Sundra vs Jim Mertz | Third | 9½ out |
| Monday, August 2 |
| » Defeated Browns (42-49), 4-3 | Griffith Stadium (30-25) | 51-47 | Won 5 |
| » Starters: Denny Galehouse vs Mickey Haefner | Third | 9 out |
| Tuesday, August 3 |
| » Defeated Browns (42-50), 7-4 | Griffith Stadium (31-25) | 52-47 | Won 6 |
| » Starters: Bobo Newsom vs Early Wynn | Second | 8 out |
| » Defeated Browns (42-51), 3-0 | Griffith Stadium (32-25) | 53-47 | Won 7 |
| » Starters: Bob Muncrief vs Milo Candini | Second | 8 out |
| Friday, August 6 |
| » Defeated Red Sox (46-50), 4-2 | Fenway Park (3-3) | 54-47 | Won 8 |
| » Starters: Dutch Leonard vs Dick Newsome | Second | 7 out |
| Saturday, August 7 |
| » Lost to Red Sox (47-50), 7-5 | Fenway Park (3-4) | 54-48 | |
| » Starters: Jim Mertz vs Joe Dobson | Second | 8 out |
| » Major-league debuts: Ox Miller (Senators) |
| Sunday, August 8 |
| » Defeated Red Sox (47-51), 4-3 | Fenway Park (4-4) | 55-48 | |
| » Starters: Early Wynn vs Mike Ryba | Second | 9 out |
| » Lost to Red Sox (48-51), 4-3 | Fenway Park (4-5) | 55-49 | |
| » Starters: Milo Candini vs Pinky Woods | Second | 9 out |
| Wednesday, August 11 |
| » Lost to Tigers (51-48), 3-2 | Tiger Stadium (3-5) | 55-50 | Lost 2 |
| » Starters: Dutch Leonard vs Dizzy Trout | Second | 8½ out |
| Thursday, August 12 |
| » Lost to Tigers (52-48), 10-3 | Tiger Stadium (3-6) | 55-51 | Lost 3 |
| » Starters: Early Wynn vs Hal White | Third | 9½ out |
| Friday, August 13 |
| » Defeated Tigers (52-49), 11-3 | Tiger Stadium (4-6) | 56-51 | |
| » Starters: Milo Candini vs Stubby Overmire | Third | 9½ out |
| Saturday, August 14 |
| » Defeated Tigers (52-50), 7-4 | Tiger Stadium (5-6) | 57-51 | Won 2 |
| » Starters: Alex Carrasquel vs Hal Newhouser | Third | 9½ out |
| Sunday, August 15 |
| » Lost to Indians (55-48), 6-2 | Cleveland Stadium (3-3) | 57-52 | |
| » Starters: Dutch Leonard vs Vern Kennedy | Third | 9½ out |
| » Defeated Indians (55-49), 4-0 | Cleveland Stadium (4-3) | 58-52 | |
| » Starters: Mickey Haefner vs Allie Reynolds | Third | 9½ out |
| Monday, August 16 |
| » Defeated Indians (55-50), 6-3 | League Park II (3-1) | 59-52 | Won 2 |
| » Starters: Bill LeFebvre vs Jim Bagby | Second | 9½ out |
| Wednesday, August 18 |
| » Lost to White Sox (56-53), 3-2 | Comiskey Park I (2-5) | 59-53 | |
| » Starters: Early Wynn vs Thornton Lee | Third | 9 out |
| » Defeated White Sox (56-54), 4-2 | Comiskey Park I (3-5) | 60-53 | |
| » Starters: Milo Candini vs Johnny Humphries | Third | 9 out |
| Thursday, August 19 |
| » Defeated White Sox (56-55), 4-3 | Comiskey Park I (4-5) | 61-53 | Won 2 |
| » Starters: Dutch Leonard vs Orval Grove | Second | 9 out |
| » Major-league debuts: Cass Michaels (White Sox) |
| Friday, August 20 |
| » Defeated White Sox (56-56), 10-5 | Comiskey Park I (5-5) | 62-53 | Won 3 |
| » Starters: Mickey Haefner vs Bill Dietrich | Second | 9 out |
| Saturday, August 21 |
| » Lost to White Sox (57-56), 5-4 | Comiskey Park I (5-6) | 62-54 | |
| » Starters: Bill LeFebvre vs Buck Ross | Second | 10 out |
| Sunday, August 22 |
| » Lost to Browns (51-60), 8-5 | Sportsman's Park III (1-3) | 62-55 | Lost 2 |
| » Starters: Early Wynn vs Bob Muncrief | Third | 9 out |
| » Defeated Browns (51-61), 4-2 | Sportsman's Park III (2-3) | 63-55 | |
| » Starters: Milo Candini vs Al Hollingsworth | Third | 9 out |
| Monday, August 23 |
| » Defeated Browns (51-62), 10-5 | Sportsman's Park III (3-3) | 64-55 | Won 2 |
| » Starters: Dutch Leonard vs Denny Galehouse | Second | 9½ out |
| » Lost to Browns (52-62), 2-1 | Sportsman's Park III (3-4) | 64-56 | |
| » Starters: Johnny Niggeling vs Nels Potter | Second | 9½ out |
| Tuesday, August 24 |
| » Defeated Browns (52-63), 10-4 | Sportsman's Park III (4-4) | 65-56 | |
| » Starters: Mickey Haefner vs Steve Sundra | Second | 9 out |
| Wednesday, August 25 |
| » Lost to Browns (53-63), 7-4 | Sportsman's Park III (4-5) | 65-57 | |
| » Starters: Bill LeFebvre vs Bobo Newsom | Second | 10½ out |
| Thursday, August 26 |
| » Defeated Browns (53-64), 9-7 | Sportsman's Park III (5-5) | 66-57 | |
| » Starters: Early Wynn vs Bob Muncrief | Second | 10½ out |
| » Lost to Browns (54-64), 4-3 | Sportsman's Park III (5-6) | 66-58 | |
| » Starters: Milo Candini vs Al Hollingsworth | Second | 10½ out |
| Saturday, August 28 |
| » Defeated Athletics (41-80), 1-0 | Griffith Stadium (33-25) | 67-58 | |
| » Starters: Roger Wolff vs Johnny Niggeling | Second | 9½ out |
| Sunday, August 29 |
| » Defeated Athletics (41-81), 5-4 | Griffith Stadium (34-25) | 68-58 | Won 2 |
| » Starters: Don Black vs Mickey Haefner | Second | 9½ out |
| » Defeated Athletics (41-82), 2-1 | Griffith Stadium (35-25) | 69-58 | Won 3 |
| » Starters: Jesse Flores vs Dutch Leonard | Second | 9½ out |
| Friday, September 3 |
| » Lost to Yankees (78-46), 4-0 | Yankee Stadium (3-5) | 69-59 | |
| » Starters: Early Wynn vs Hank Borowy | Second | 11 out |
| Saturday, September 4 |
| » Lost to Yankees (79-46), 2-1 | Yankee Stadium (3-6) | 69-60 | Lost 2 |
| » Starters: Johnny Niggeling vs Spud Chandler | Third | 12 out |
| Sunday, September 5 |
| » Defeated Yankees (79-47), 3-2 | Yankee Stadium (4-6) | 70-60 | |
| » Starters: Dutch Leonard vs Butch Wensloff | Second | 10 out |
| » Defeated Yankees (79-48), 5-1 | Yankee Stadium (5-6) | 71-60 | Won 2 |
| » Starters: Bobo Newsom vs Tiny Bonham | Second | 10 out |
| Monday, September 6 |
| » Lost to Red Sox (61-69), 5-1 | Fenway Park (4-6) | 71-61 | |
| » Starters: Milo Candini vs Tex Hughson | Third | 11 out |
| » Lost to Red Sox (62-69), 4-1 | Fenway Park (4-7) | 71-62 | Lost 2 |
| » Starters: Jim Mertz vs Joe Dobson | Third | 11 out |
| Friday, September 10 |
| » Defeated Athletics (44-85), 5-0 | Shibe Park (6-2) | 72-62 | |
| » Starters: Early Wynn vs Roger Wolff | Third | 11½ out |
| Saturday, September 11 |
| » Defeated Athletics (44-86), 9-1 | Shibe Park (7-2) | 73-62 | Won 2 |
| » Starters: Bobo Newsom vs Lum Harris | Third | 11½ out |
| Sunday, September 12 |
| » Defeated Athletics (44-87), 4-3 | Shibe Park (8-2) | 74-62 | Won 3 |
| » Starters: Dutch Leonard vs Jesse Flores | Third | 11½ out |
| » Defeated Athletics (44-88), 9-5 | Shibe Park (9-2) | 75-62 | Won 4 |
| » Starters: Mickey Haefner vs Don Black | Third | 11½ out |
| Tuesday, September 14 |
| » Defeated Red Sox (62-75), 3-2 | Griffith Stadium (36-25) | 76-62 | Won 5 |
| » Starters: Dick Newsome vs Milo Candini | Second | 11½ out |
| » Major-league debuts: Danny Doyle (Red Sox) |
| Wednesday, September 15 |
| » Defeated Red Sox (62-76), 5-0 | Griffith Stadium (37-25) | 77-62 | Won 6 |
| » Starters: Tex Hughson vs Johnny Niggeling | Second | 11½ out |
| Friday, September 17 |
| » Defeated Yankees (88-50), 6-3 | Griffith Stadium (38-25) | 78-62 | Won 7 |
| » Starters: Butch Wensloff vs Bobo Newsom | Second | 11 out |
| Sunday, September 19 |
| » Defeated Yankees (88-51), 3-2 | Griffith Stadium (39-25) | 79-62 | Won 8 |
| » Starters: Spud Chandler vs Early Wynn | Second | 9 out |
| » Defeated Yankees (88-52), 5-1 | Griffith Stadium (40-25) | 80-62 | Won 9 |
| » Starters: Tiny Bonham vs Mickey Haefner | Second | 9 out |
| Wednesday, September 22 |
| » Defeated Browns (66-75), 4-0 | Griffith Stadium (41-25) | 81-62 | Won 10 |
| » Starters: Al Hollingsworth vs Johnny Niggeling | Second | 9½ out |
| » Lost to Browns (67-75), 9-1 | Griffith Stadium (41-26) | 81-63 | |
| » Starters: Denny Galehouse vs Milo Candini | Second | 9½ out |
| Thursday, September 23 |
| » Lost to Browns (68-75), 12-3 | Griffith Stadium (41-27) | 81-64 | Lost 2 |
| » Starters: Al Milnar vs Bobo Newsom | Second | 10½ out |
| Sunday, September 26 |
| » Lost to White Sox (76-70), 15-3 | Griffith Stadium (41-28) | 81-65 | Lost 3 |
| » Starters: Eddie Smith vs Early Wynn | Second | 11½ out |
| » Defeated White Sox (76-71), 5-2 | Griffith Stadium (42-28) | 82-65 | |
| » Starters: Johnny Humphries vs Mickey Haefner | Second | 11½ out |
| Monday, September 27 |
| » Lost to White Sox (77-71), 2-1 | Griffith Stadium (42-29) | 82-66 | |
| » Starters: Buck Ross vs Dutch Leonard | Second | 13 out |
| » Lost to White Sox (78-71), 2-1 | Griffith Stadium (42-30) | 82-67 | Lost 2 |
| » Starters: Orval Grove vs Bobo Newsom | Second | 13 out |
| Wednesday, September 29 |
| » Defeated Indians (79-70), 6-2 | Griffith Stadium (43-30) | 83-67 | |
| » Starters: Vern Kennedy vs Johnny Niggeling | Second | 11½ out |
| » Defeated Indians (79-71), 7-4 | Griffith Stadium (44-30) | 84-67 | Won 2 |
| » Starters: Jim Bagby vs Early Wynn | Second | 11½ out |
| Saturday, October 2 |
| » Lost to Tigers (77-76), 12-5 | Griffith Stadium (44-31) | 84-68 | |
| » Starters: Virgil Trucks vs Bobo Newsom | Second | 12½ out |
| Sunday, October 3 |
| » Lost to Tigers (78-76), 4-1 | Griffith Stadium (44-32) | 84-69 | Lost 2 |
| » Starters: Dizzy Trout vs Mickey Haefner | Second | 13½ out |
| Thursday, November 18 |
| Future Senator Jim Shellenback is born in Riverside, CA. |
| Friday, December 3 |
| Former Senator Mike Grady dies in Kennett Square, PA at the age of 74. |
| Tuesday, December 21 |
| Former Senator Jack Warner dies in Far Rockaway, NY at the age of 72. |
Game information provided by Retrosheet (www.retrosheet.org) |
