| Saturday, April 3 |
| Future Indian Barry Moore is born in Statesville, NC. |
| Monday, April 12 |
| Future Indian Vincente Romo is born in Santa Rosalia, Mexico. Future Indian Ken Suarez is born in Tampa, FL. |
| Wednesday, April 21 |
| » Defeated Tigers (0-1), 1-0 | Cleveland Stadium (1-0) | 1-0 | |
| » Starters: Tommy Bridges vs Jim Bagby | First | -- |
| » Major-league debuts: Joe Hoover (Tigers) |
| Thursday, April 22 |
| » Lost to Tigers (1-1), 4-0 | League Park II (0-1) | 1-1 | |
| » Starters: Virgil Trucks vs Mel Harder | Second | ½ out |
| Friday, April 23 |
| » Major-league debuts: Tom McBride and Roy Partee (Red Sox) |
| Saturday, April 24 |
| » Defeated Tigers (1-2), 3-2 | League Park II (1-1) | 2-1 | |
| » Starters: Hal White vs Vern Kennedy | Second | ½ out |
| Sunday, April 25 |
| » Defeated Tigers (1-3), 4-1 | Cleveland Stadium (2-0) | 3-1 | Won 2 |
| » Starters: Dizzy Trout vs Jim Bagby | Third | 1 out |
| » Lost to Tigers (2-3), 4-1 | Cleveland Stadium (2-1) | 3-2 | |
| » Starters: Stubby Overmire vs Mike Naymick | Third | 1 out |
| » Major-league debuts: Stubby Overmire (Tigers) |
| Future Indian Bob Johnson is born in Aurora, IL. |
| Tuesday, April 27 |
| » Defeated White Sox (1-3), 4-2 | Comiskey Park I (1-0) | 4-2 | |
| » Starters: Mel Harder vs Thornton Lee | Second | 1 out |
| » Major-league debuts: Gordon Malzberger (White Sox) |
| Wednesday, April 28 |
| » Defeated White Sox (1-4), 2-0 | Comiskey Park I (2-0) | 5-2 | Won 2 |
| » Starters: Al Smith vs Bill Dietrich | Second | 1 out |
| Saturday, May 1 |
| » Lost to Tigers (5-3), 3-2 | Tiger Stadium (0-1) | 5-3 | |
| » Starters: Vern Kennedy vs Hal White | Second | 1 out |
| Sunday, May 2 |
| » Defeated Tigers (5-4), 5-2 | Tiger Stadium (1-1) | 6-3 | |
| » Starters: Mel Harder vs Johnny Gorsica | Second | ½ out |
| Tuesday, May 4 |
| » Defeated White Sox (2-7), 2-1 | League Park II (2-1) | 7-3 | Won 2 |
| » Starters: Bill Dietrich vs Jim Bagby | Second | ½ out |
| Wednesday, May 5 |
| » Defeated White Sox (2-8), 2-1 | League Park II (3-1) | 8-3 | Won 3 |
| » Starters: Eddie Smith vs Chubby Dean | Second | 1 out |
| » Lost to White Sox (3-8), 5-2 | League Park II (3-2) | 8-4 | |
| » Starters: Buck Ross vs Al Milnar | Second | 1 out |
| Thursday, May 6 |
| » Defeated White Sox (3-9), 6-3 | League Park II (4-2) | 9-4 | |
| » Starters: Jake Wade vs Al Smith | Second | 1½ out |
| Saturday, May 8 |
| » Lost to Browns (6-6), 3-2 | Sportsman's Park III (0-1) | 9-5 | |
| » Starters: Mel Harder vs Steve Sundra | Second | 2 out |
| Sunday, May 9 |
| » Defeated Browns (6-7), 6-5 | Sportsman's Park III (1-1) | 10-5 | |
| » Starters: Jim Bagby vs Johnny Niggeling | Second | 2 out |
| » Lost to Browns (7-7), 7-5 | Sportsman's Park III (1-2) | 10-6 | |
| » Starters: Al Milnar vs Bob Muncrief | Second | 2 out |
| Wednesday, May 12 |
| » Defeated Senators (10-10), 8-2 | Cleveland Stadium (3-1) | 11-6 | |
| » Starters: Early Wynn vs Chubby Dean | Second | 1 out |
| Thursday, May 13 |
| » Lost to Senators (11-10), 3-2 | League Park II (4-3) | 11-7 | |
| » Starters: Ewald Pyle vs Al Smith | Second | 1½ out |
| Friday, May 14 |
| » Lost to Senators (12-10), 3-1 | League Park II (4-4) | 11-8 | Lost 2 |
| » Starters: Dutch Leonard vs Jim Bagby | Second | 1½ out |
| Saturday, May 15 |
| » Defeated Athletics (10-13), 2-0 | League Park II (5-4) | 12-8 | |
| » Starters: Orie Arntzen vs Jack Salveson | Second | 1 out |
| Sunday, May 16 |
| » Lost to Athletics (11-13), 5-3 | Cleveland Stadium (3-2) | 12-9 | |
| » Starters: Jesse Flores vs Al Milnar | Second | 1 out |
| » Defeated Athletics (11-14), 3-2 | Cleveland Stadium (4-2) | 13-9 | |
| » Starters: Don Black vs Vern Kennedy | Second | 1 out |
| Thursday, May 20 |
| » Lost to Red Sox (9-14), 2-1 | League Park II (5-5) | 13-10 | |
| » Starters: Oscar Judd vs Jack Salveson | Third | 2 out |
| » Lost to Red Sox (10-14), 7-4 | League Park II (5-6) | 13-11 | Lost 2 |
| » Starters: Ken Chase vs Pete Center | Third | 2 out |
| Saturday, May 22 |
| » Defeated Yankees (14-9), 9-2 | Cleveland Stadium (5-2) | 14-11 | |
| » Starters: Hank Borowy vs Jim Bagby | Second | 1 out |
| Future Indian Tommy John is born in Terre Haute, IN. Former Indian Bob Wood dies in Churchill, OH at the age of 78 |
| Sunday, May 23 |
| » Defeated Yankees (14-10), 3-1 | Cleveland Stadium (6-2) | 15-11 | Won 2 |
| » Starters: Tiny Bonham vs Al Smith | First | -- |
| » Defeated Yankees (14-11), 5-2 | Cleveland Stadium (7-2) | 16-11 | Won 3 |
| » Starters: Spud Chandler vs Chubby Dean | First | -- |
| Thursday, May 27 |
| » Lost to Red Sox (12-17), 2-0 | Fenway Park (0-1) | 16-12 | |
| » Starters: Mike Naymick vs Tex Hughson | Second | ½ out |
| » Lost to Red Sox (13-17), 4-3 | Fenway Park (0-2) | 16-13 | Lost 2 |
| » Starters: Jim Bagby vs Oscar Judd | Second | ½ out |
| Friday, May 28 |
| » Defeated Red Sox (13-18), 5-2 | Fenway Park (1-2) | 17-13 | |
| » Starters: Jack Salveson vs Ken Chase | First | -- |
| Saturday, May 29 |
| » Lost to Yankees (16-12), 9-5 | Yankee Stadium (0-1) | 17-14 | |
| » Starters: Chubby Dean vs Tiny Bonham | Third | 1 out |
| Sunday, May 30 |
| » Lost to Yankees (17-12), 4-3 | Yankee Stadium (0-2) | 17-15 | Lost 2 |
| » Starters: Al Smith vs Spud Chandler | Fourth | 2½ out |
| » Lost to Yankees (18-12), 3-2 | Yankee Stadium (0-3) | 17-16 | Lost 3 |
| » Starters: Joe Heving vs Butch Wensloff | Fourth | 2½ out |
| Monday, May 31 |
| » Lost to Senators (19-15), 8-7 | Griffith Stadium (0-1) | 17-17 | Lost 4 |
| » Starters: Jim Bagby vs Dutch Leonard | Fourth | 2½ out |
| » Defeated Senators (19-16), 7-6 | Griffith Stadium (1-1) | 18-17 | |
| » Starters: Al Milnar vs Early Wynn | Fourth | 2½ out |
| Future Indian Jackie Brown is born in Holdenville, OK. |
| Tuesday, June 1 |
| » Lost to Senators (20-16), 3-2 | Griffith Stadium (1-2) | 18-18 | |
| » Starters: Vern Kennedy vs Ewald Pyle | Fifth | 3 out |
| Wednesday, June 2 |
| » Lost to Senators (21-16), 13-1 | Griffith Stadium (1-3) | 18-19 | Lost 2 |
| » Starters: Jack Salveson vs Milo Candini | Fifth | 3 out |
| Thursday, June 3 |
| » Lost to Athletics (20-19), 10-4 | Shibe Park (0-1) | 18-20 | Lost 3 |
| » Starters: Chubby Dean vs Don Black | Sixth | 4 out |
| Friday, June 4 |
| » Defeated Athletics (20-20), 3-2 | Shibe Park (1-1) | 19-20 | |
| » Starters: Al Smith vs Jesse Flores | Sixth | 4 out |
| Saturday, June 5 |
| » Lost to Athletics (21-20), 6-5 | Shibe Park (1-2) | 19-21 | |
| » Starters: Jim Bagby vs Orie Arntzen | Sixth | 4 out |
| » Major-league debuts: Mickey Rocco (Indians) |
| Sunday, June 6 |
| » Lost to Athletics (22-20), 12-5 | Shibe Park (1-3) | 19-22 | Lost 2 |
| » Starters: Allie Reynolds vs Russ Christopher | Sixth | 5 out |
| » Defeated Athletics (22-21), 5-0 | Shibe Park (2-3) | 20-22 | |
| » Starters: Jack Salveson vs Roger Wolff | Sixth | 5 out |
| Wednesday, June 9 |
| » Lost to Browns (14-23), 6-0 | League Park II (5-7) | 20-23 | |
| » Starters: Bob Muncrief vs Jim Bagby | Seventh | 5½ out |
| » Major-league debuts: Pat Seerey (Indians) |
| Thursday, June 10 |
| » Lost to Browns (15-23), 2-1 | Cleveland Stadium (7-3) | 20-24 | Lost 2 |
| » Starters: Johnny Niggeling vs Al Smith | Seventh | 6½ out |
| Saturday, June 12 |
| » Lost to Browns (16-23), 7-6 | Cleveland Stadium (7-4) | 20-25 | Lost 3 |
| » Starters: Al Hollingsworth vs Jack Salveson | Sixth | 8 out |
| Sunday, June 13 |
| » Lost to Browns (17-23), 3-1 | Cleveland Stadium (7-5) | 20-26 | Lost 4 |
| » Starters: Bob Muncrief vs Al Milnar | Seventh | 7 out |
| » Defeated Browns (17-24), 2-1 | Cleveland Stadium (8-5) | 21-26 | |
| » Starters: Denny Galehouse vs Jim Bagby | Seventh | 7 out |
| Thursday, June 17 |
| » Defeated Tigers (23-22), 3-2 | Cleveland Stadium (9-5) | 22-26 | Won 2 |
| » Starters: Hal Newhouser vs Jack Salveson | Seventh | 7 out |
| » Defeated Tigers (23-23), 6-5 | Cleveland Stadium (10-5) | 23-26 | Won 3 |
| » Starters: Dizzy Trout vs Jim Bagby | Seventh | 7 out |
| Friday, June 18 |
| » Defeated White Sox (21-24), 5-3 | Comiskey Park I (3-0) | 24-26 | Won 4 |
| » Starters: Al Smith vs Eddie Smith | Sixth | 6 out |
| Saturday, June 19 |
| » Defeated White Sox (21-25), 5-4 | Comiskey Park I (4-0) | 25-26 | Won 5 |
| » Starters: Ray Poat vs Johnny Humphries | Fourth | 5½ out |
| » Defeated White Sox (21-26), 10-8 | Comiskey Park I (5-0) | 26-26 | Won 6 |
| » Starters: Chubby Dean vs Thornton Lee | Fourth | 5½ out |
| Sunday, June 20 |
| » Lost to White Sox (22-26), 10-6 | Comiskey Park I (5-1) | 26-27 | |
| » Starters: Allie Reynolds vs Orval Grove | Third | 5½ out |
| » Defeated White Sox (22-27), 7-2 | Comiskey Park I (6-1) | 27-27 | |
| » Starters: Jim Bagby vs Bill Dietrich | Third | 5½ out |
| Wednesday, June 23 |
| » Lost to Tigers (25-26), 3-1 | Tiger Stadium (1-2) | 27-28 | |
| » Starters: Jack Salveson vs Hal Newhouser | Fourth | 5 out |
| » Defeated Tigers (25-27), 9-6 | Tiger Stadium (2-2) | 28-28 | |
| » Starters: Vern Kennedy vs Hal White | Fourth | 5 out |
| Thursday, June 24 |
| » Lost to Tigers (26-27), 7-4 | Tiger Stadium (2-3) | 28-29 | |
| » Starters: Jim Bagby vs Virgil Trucks | Fifth | 5½ out |
| Friday, June 25 |
| » Defeated White Sox (25-29), 6-2 | Cleveland Stadium (11-5) | 29-29 | |
| » Starters: Jake Wade vs Al Smith | Third | 5 out |
| Saturday, June 26 |
| » Lost to White Sox (26-29), 3-2 | Cleveland Stadium (11-6) | 29-30 | |
| » Starters: Thornton Lee vs Chubby Dean | Fourth | 5 out |
| Sunday, June 27 |
| » Defeated White Sox (26-30), 2-1 | Cleveland Stadium (12-6) | 30-30 | |
| » Starters: Johnny Humphries vs Jack Salveson | Fourth | 5 out |
| » Lost to White Sox (27-30), 2-0 | Cleveland Stadium (12-7) | 30-31 | |
| » Starters: Eddie Smith vs Vern Kennedy | Fourth | 5 out |
| Wednesday, June 30 |
| » Lost to Yankees (34-24), 3-1 | Cleveland Stadium (12-8) | 30-32 | Lost 2 |
| » Starters: Hank Borowy vs Jim Bagby | Fourth | 6 out |
| Thursday, July 1 |
| » Defeated Yankees (34-25), 3-2 | League Park II (6-7) | 31-32 | |
| » Starters: Butch Wensloff vs Al Smith | Fifth | 5 out |
| Friday, July 2 |
| » Defeated Yankees (34-26), 12-0 | League Park II (7-7) | 32-32 | Won 2 |
| » Starters: Marius Russo vs Allie Reynolds | Third | 4 out |
| Saturday, July 3 |
| » Lost to Red Sox (33-33), 12-4 | Cleveland Stadium (12-9) | 32-33 | |
| » Starters: Joe Dobson vs Chubby Dean | Sixth | 3½ out |
| Monday, July 5 |
| » Lost to Athletics (31-40), 2-1 | Cleveland Stadium (12-10) | 32-34 | Lost 2 |
| » Starters: Don Black vs Jim Bagby | Fifth | 5½ out |
| » Lost to Athletics (32-40), 7-0 | Cleveland Stadium (12-11) | 32-35 | Lost 3 |
| » Starters: Lum Harris vs Vern Kennedy | Fifth | 5½ out |
| Tuesday, July 6 |
| » Defeated Athletics (32-41), 2-0 | Cleveland Stadium (13-11) | 33-35 | |
| » Starters: Orie Arntzen vs Al Smith | Sixth | 5½ out |
| Thursday, July 8 |
| » Defeated Senators (37-36), 5-2 | League Park II (8-7) | 34-35 | Won 2 |
| » Starters: Ewald Pyle vs Allie Reynolds | Fifth | 5 out |
| Future Indian George Culver is born in Salinas, CA. |
| Friday, July 9 |
| » Lost to Senators (38-36), 1-0 | Cleveland Stadium (13-12) | 34-36 | |
| » Starters: Dutch Leonard vs Jim Bagby | Fifth | 5½ out |
| Saturday, July 10 |
| » Lost to Senators (39-36), 4-0 | Cleveland Stadium (13-13) | 34-37 | Lost 2 |
| » Starters: Early Wynn vs Vern Kennedy | Sixth | 7 out |
| Sunday, July 11 |
| » Defeated Senators (39-37), 5-1 | Cleveland Stadium (14-13) | 35-37 | |
| » Starters: Milo Candini vs Al Smith | Sixth | 8 out |
| » Lost to Senators (40-37), 6-4 | Cleveland Stadium (14-14) | 35-38 | |
| » Starters: Ray Scarborough vs Allie Reynolds | Sixth | 8 out |
| Thursday, July 15 |
| » Lost to Browns (36-37), 2-1 | Sportsman's Park III (1-3) | 35-39 | Lost 2 |
| » Starters: Jim Bagby vs Steve Sundra | Sixth | 8½ out |
| Friday, July 16 |
| » Lost to Browns (37-37), 4-3 | Sportsman's Park III (1-4) | 35-40 | Lost 3 |
| » Starters: Al Smith vs Bob Muncrief | Seventh | 9½ out |
| Saturday, July 17 |
| » Lost to Browns (38-37), 3-1 | Sportsman's Park III (1-5) | 35-41 | Lost 4 |
| » Starters: Allie Reynolds vs Denny Galehouse | Seventh | 10½ out |
| Sunday, July 18 |
| » Defeated Browns (38-38), 4-3 | Sportsman's Park III (2-5) | 36-41 | |
| » Starters: Al Milnar vs Johnny Niggeling | Sixth | 10½ out |
| » Defeated Browns (38-39), 10-7 | Sportsman's Park III (3-5) | 37-41 | Won 2 |
| » Starters: Jim Bagby vs Bobo Newsom | Sixth | 10½ out |
| Wednesday, July 21 |
| » Defeated Athletics (34-49), 7-0 | Shibe Park (3-3) | 38-41 | Won 3 |
| » Starters: Al Smith vs Jesse Flores | Fifth | 9½ out |
| Thursday, July 22 |
| » Defeated Athletics (34-50), 2-1 | Shibe Park (4-3) | 39-41 | Won 4 |
| » Starters: Jim Bagby vs Orie Arntzen | Sixth | 9½ out |
| Friday, July 23 |
| » Defeated Athletics (34-51), 1-0 | Shibe Park (5-3) | 40-41 | Won 5 |
| » Starters: Mel Harder vs Don Black | Fifth | 9½ out |
| Saturday, July 24 |
| » Defeated Senators (45-42), 2-0 | Griffith Stadium (2-3) | 41-41 | Won 6 |
| » Starters: Allie Reynolds vs Mickey Haefner | Fourth | 9 out |
| Sunday, July 25 |
| » Defeated Senators (45-43), 8-2 | Griffith Stadium (3-3) | 42-41 | Won 7 |
| » Starters: Vern Kennedy vs Milo Candini | Fourth | 9 out |
| » Lost to Senators (46-43), 7-2 | Griffith Stadium (3-4) | 42-42 | |
| » Starters: Ray Poat vs Jim Mertz | Fourth | 9 out |
| Monday, July 26 |
| » Defeated Senators (46-44), 7-3 | Griffith Stadium (4-4) | 43-42 | |
| » Starters: Jim Bagby vs Early Wynn | Fourth | 9 out |
| Tuesday, July 27 |
| » Lost to Yankees (53-33), 4-3 | Yankee Stadium (0-4) | 43-43 | |
| » Starters: Al Smith vs Hank Borowy | Fourth | 10 out |
| Wednesday, July 28 |
| » Defeated Yankees (53-34), 6-2 | Yankee Stadium (1-4) | 44-43 | |
| » Starters: Mel Harder vs Spud Chandler | Second | 9 out |
| Thursday, July 29 |
| » Lost to Yankees (54-34), 11-1 | Yankee Stadium (1-5) | 44-44 | |
| » Starters: Vern Kennedy vs Marius Russo | Fourth | 10 out |
| Friday, July 30 |
| » Lost to Yankees (55-34), 5-4 | Yankee Stadium (1-6) | 44-45 | Lost 2 |
| » Starters: Jim Bagby vs Tiny Bonham | Fourth | 11 out |
| Saturday, July 31 |
| » Lost to Red Sox (45-47), 5-4 | Fenway Park (1-3) | 44-46 | Lost 3 |
| » Starters: Allie Reynolds vs Mike Ryba | Fifth | 11 out |
| Sunday, August 1 |
| » Defeated Red Sox (45-48), 8-6 | Fenway Park (2-3) | 45-46 | |
| » Starters: Al Smith vs Oscar Judd | Fifth | 12 out |
| » Lost to Red Sox (46-48), 4-1 | Fenway Park (2-4) | 45-47 | |
| » Starters: Mel Harder vs Dick Newsome | Fifth | 12 out |
| Tuesday, August 3 |
| » Defeated Red Sox (46-49), 11-9 | Fenway Park (3-4) | 46-47 | |
| » Starters: Jim Bagby vs Yank Terry | Fifth | 11½ out |
| » Major-league debuts: Emmett O'Neill (Red Sox) |
| Friday, August 6 |
| » Defeated Browns (42-52), 1-0 | Cleveland Stadium (15-14) | 47-47 | Won 2 |
| » Starters: Johnny Niggeling vs Allie Reynolds | Fifth | 10½ out |
| Saturday, August 7 |
| » Lost to Browns (43-52), 2-0 | League Park II (8-8) | 47-48 | |
| » Starters: Steve Sundra vs Al Smith | Fifth | 11½ out |
| Sunday, August 8 |
| » Defeated Browns (43-53), 6-5 | Cleveland Stadium (16-14) | 48-48 | |
| » Starters: Bob Muncrief vs Mel Harder | Fourth | 11½ out |
| » Defeated Browns (43-54), 5-2 | Cleveland Stadium (17-14) | 49-48 | Won 2 |
| » Starters: Bobo Newsom vs Jim Bagby | Fourth | 11½ out |
| Wednesday, August 11 |
| » Defeated Athletics (40-62), 10-5 | Cleveland Stadium (18-14) | 50-48 | Won 3 |
| » Starters: Lou Ciola vs Allie Reynolds | Third | 9½ out |
| » Defeated Athletics (40-63), 2-1 | Cleveland Stadium (19-14) | 51-48 | Won 4 |
| » Starters: Roger Wolff vs Al Smith | Third | 9½ out |
| Thursday, August 12 |
| » Defeated Athletics (40-64), 4-3 | League Park II (9-8) | 52-48 | Won 5 |
| » Starters: Orie Arntzen vs Jim Bagby | Second | 9½ out |
| Friday, August 13 |
| » Defeated Athletics (40-65), 6-4 | League Park II (10-8) | 53-48 | Won 6 |
| » Starters: Don Black vs Mel Harder | Second | 9½ out |
| Saturday, August 14 |
| » Defeated Athletics (40-66), 12-9 | League Park II (11-8) | 54-48 | Won 7 |
| » Starters: Everett Fagan vs Chubby Dean | Second | 9½ out |
| Sunday, August 15 |
| » Defeated Senators (57-52), 6-2 | Cleveland Stadium (20-14) | 55-48 | Won 8 |
| » Starters: Dutch Leonard vs Vern Kennedy | Second | 9½ out |
| » Lost to Senators (58-52), 4-0 | Cleveland Stadium (20-15) | 55-49 | |
| » Starters: Mickey Haefner vs Allie Reynolds | Second | 9½ out |
| Monday, August 16 |
| » Lost to Senators (59-52), 6-3 | League Park II (11-9) | 55-50 | Lost 2 |
| » Starters: Bill LeFebvre vs Jim Bagby | Third | 10½ out |
| Wednesday, August 18 |
| » Defeated Yankees (67-41), 9-8 | League Park II (12-9) | 56-50 | |
| » Starters: Bill Zuber vs Al Smith | Second | 9 out |
| » Defeated Yankees (67-42), 7-5 | League Park II (13-9) | 57-50 | Won 2 |
| » Starters: Spud Chandler vs Mel Harder | Second | 9 out |
| Thursday, August 19 |
| » Lost to Yankees (68-42), 2-1 | Cleveland Stadium (20-16) | 57-51 | |
| » Starters: Tiny Bonham vs Allie Reynolds | Third | 10 out |
| Friday, August 20 |
| » Lost to Yankees (69-42), 10-5 | League Park II (13-10) | 57-52 | Lost 2 |
| » Starters: Atley Donald vs Vern Kennedy | Fourth | 11 out |
| Saturday, August 21 |
| » Lost to Yankees (70-42), 8-3 | League Park II (13-11) | 57-53 | Lost 3 |
| » Starters: Hank Borowy vs Jim Bagby | Fourth | 12 out |
| Sunday, August 22 |
| » Defeated Red Sox (55-60), 6-0 | Cleveland Stadium (21-16) | 58-53 | |
| » Starters: Mike Ryba vs Jack Salveson | Fourth | 10 out |
| » Defeated Red Sox (55-61), 7-6 | Cleveland Stadium (22-16) | 59-53 | Won 2 |
| » Starters: Yank Terry vs Mike Naymick | Fourth | 10 out |
| Monday, August 23 |
| » Lost to Red Sox (56-61), 9-7 | League Park II (13-12) | 59-54 | |
| » Starters: Pinky Woods vs Al Smith | Fourth | 11 out |
| Tuesday, August 24 |
| » Defeated Red Sox (56-62), 5-2 | Cleveland Stadium (23-16) | 60-54 | |
| » Starters: Emmett O'Neill vs Allie Reynolds | Fourth | 11 out |
| » Lost to Red Sox (57-62), 7-0 | Cleveland Stadium (23-17) | 60-55 | |
| » Starters: Dick Newsome vs Mel Harder | Fourth | 11 out |
| Wednesday, August 25 |
| » Defeated Red Sox (57-63), 8-3 | League Park II (14-12) | 61-55 | |
| » Starters: Joe Dobson vs Vern Kennedy | Third | 11 out |
| » Defeated Red Sox (57-64), 4-1 | League Park II (15-12) | 62-55 | Won 2 |
| » Starters: Tex Hughson vs Ray Poat | Third | 11 out |
| Thursday, August 26 |
| » Lost to Red Sox (58-64), 4-1 | League Park II (15-13) | 62-56 | |
| » Starters: Mike Ryba vs Mike Naymick | Fourth | 11½ out |
| Friday, August 27 |
| » Defeated White Sox (63-58), 6-2 | Comiskey Park I (7-1) | 63-56 | |
| » Starters: Al Smith vs Eddie Smith | Third | 11 out |
| Saturday, August 28 |
| » Lost to White Sox (64-58), 7-6 | Comiskey Park I (7-2) | 63-57 | |
| » Starters: Jack Salveson vs Thornton Lee | Fourth | 11 out |
| Future Indian Lou Piniella is born in Tampa, FL. |
| Sunday, August 29 |
| » Defeated White Sox (64-59), 2-1 | Comiskey Park I (8-2) | 64-57 | |
| » Starters: Mel Harder vs Orval Grove | Third | 11 out |
| » Defeated White Sox (64-60), 6-1 | Comiskey Park I (9-2) | 65-57 | Won 2 |
| » Starters: Allie Reynolds vs Johnny Humphries | Third | 11 out |
| Thursday, September 2 |
| » Defeated White Sox (64-61), 2-1 | Cleveland Stadium (24-17) | 66-57 | Won 3 |
| » Starters: Orval Grove vs Al Smith | Third | 11 out |
| Sunday, September 5 |
| » Lost to White Sox (65-61), 2-1 | Cleveland Stadium (24-18) | 66-58 | |
| » Starters: Bill Dietrich vs Mel Harder | Third | 12 out |
| » Lost to White Sox (66-61), 4-3 | Cleveland Stadium (24-19) | 66-59 | Lost 2 |
| » Starters: Johnny Humphries vs Allie Reynolds | Third | 12 out |
| Monday, September 6 |
| » Defeated Browns (58-70), 3-2 | Cleveland Stadium (25-19) | 67-59 | |
| » Starters: Steve Sundra vs Jim Bagby | Second | 11 out |
| » Defeated Browns (58-71), 2-0 | Cleveland Stadium (26-19) | 68-59 | Won 2 |
| » Starters: Denny Galehouse vs Vern Kennedy | Second | 11 out |
| Thursday, September 9 |
| » Defeated Tigers (68-61), 8-3 | Tiger Stadium (3-3) | 69-59 | Won 3 |
| » Starters: Al Smith vs Virgil Trucks | Second | 11½ out |
| » Lost to Tigers (69-61), 10-3 | Tiger Stadium (3-4) | 69-60 | |
| » Starters: Allie Reynolds vs Hal White | Second | 11½ out |
| Friday, September 10 |
| » Defeated Tigers (69-62), 4-2 | Tiger Stadium (4-4) | 70-60 | |
| » Starters: Mel Harder vs Hal Newhouser | Second | 11 out |
| » Defeated Tigers (69-63), 1-0 | Tiger Stadium (5-4) | 71-60 | Won 2 |
| » Starters: Jim Bagby vs Rufe Gentry | Second | 11 out |
| » Major-league debuts: Rufe Gentry (Tigers) |
| Saturday, September 11 |
| » Defeated Tigers (69-64), 7-2 | Tiger Stadium (6-4) | 72-60 | Won 3 |
| » Starters: Vern Kennedy vs Dizzy Trout | Second | 11 out |
| Sunday, September 12 |
| » Defeated Tigers (69-65), 2-1 | Tiger Stadium (7-4) | 73-60 | Won 4 |
| » Starters: Allie Reynolds vs Tommy Bridges | Second | 11½ out |
| Tuesday, September 14 |
| » Lost to Browns (63-71), 3-0 | Sportsman's Park III (3-6) | 73-61 | |
| » Starters: Jim Bagby vs Steve Sundra | Third | 13 out |
| » Lost to Browns (64-71), 7-1 | Sportsman's Park III (3-7) | 73-62 | Lost 2 |
| » Starters: Al Smith vs Nels Potter | Third | 13 out |
| Wednesday, September 15 |
| » Lost to Browns (65-71), 4-2 | Sportsman's Park III (3-8) | 73-63 | Lost 3 |
| » Starters: Mel Harder vs Al Hollingsworth | Third | 14 out |
| Friday, September 17 |
| » Lost to Tigers (72-66), 2-1 | Cleveland Stadium (26-20) | 73-64 | Lost 4 |
| » Starters: Dizzy Trout vs Allie Reynolds | Third | 14½ out |
| Saturday, September 18 |
| » Defeated Tigers (72-67), 4-2 | League Park II (16-13) | 74-64 | |
| » Starters: Hal Newhouser vs Vern Kennedy | Third | 14 out |
| Sunday, September 19 |
| » Defeated Tigers (72-68), 1-0 | Cleveland Stadium (27-20) | 75-64 | Won 2 |
| » Starters: Hal White vs Jim Bagby | Third | 12 out |
| » Defeated Tigers (72-69), 6-2 | Cleveland Stadium (28-20) | 76-64 | Won 3 |
| » Starters: Tommy Bridges vs Al Smith | Third | 12 out |
| Thursday, September 23 |
| » Lost to Red Sox (64-78), 13-7 | Fenway Park (3-5) | 76-65 | |
| » Starters: Mel Harder vs Dick Newsome | Third | 13 out |
| » Defeated Red Sox (64-79), 6-4 | Fenway Park (4-5) | 77-65 | |
| » Starters: Allie Reynolds vs Tex Hughson | Third | 13 out |
| » Major-league debuts: Gene Woodling (Indians) |
| Future Indian Marcelino Lopez is born in Havana, Cuba. |
| Friday, September 24 |
| » Lost to Red Sox (65-79), 1-0 | Fenway Park (4-6) | 77-66 | |
| » Starters: Ed Klieman vs Joe Dobson | Third | 13 out |
| Saturday, September 25 |
| » Defeated Red Sox (65-80), 6-3 | Fenway Park (5-6) | 78-66 | |
| » Starters: Jim Bagby vs Emmett O'Neill | Third | 13 out |
| Sunday, September 26 |
| » Lost to Yankees (92-53), 3-2 | Yankee Stadium (1-7) | 78-67 | |
| » Starters: Al Smith vs Tiny Bonham | Third | 15 out |
| » Lost to Yankees (93-53), 6-5 | Yankee Stadium (1-8) | 78-68 | Lost 2 |
| » Starters: Ray Poat vs Atley Donald | Third | 15 out |
| Monday, September 27 |
| » Lost to Yankees (94-53), 5-2 | Yankee Stadium (1-9) | 78-69 | Lost 3 |
| » Starters: Allie Reynolds vs Hank Borowy | Third | 16 out |
| Tuesday, September 28 |
| » Defeated Yankees (94-54), 11-3 | Yankee Stadium (2-9) | 79-69 | |
| » Starters: Mel Harder vs Marv Breuer | Third | 15 out |
| Wednesday, September 29 |
| » Lost to Senators (83-67), 6-2 | Griffith Stadium (4-5) | 79-70 | |
| » Starters: Vern Kennedy vs Johnny Niggeling | Third | 16 out |
| » Lost to Senators (84-67), 7-4 | Griffith Stadium (4-6) | 79-71 | Lost 2 |
| » Starters: Jim Bagby vs Early Wynn | Third | 16 out |
| Thursday, September 30 |
| » Major-league debuts: Ed Busch (Athletics) |
| Saturday, October 2 |
| » Defeated Athletics (49-103), 8-3 | Shibe Park (6-3) | 80-71 | |
| » Starters: Allie Reynolds vs Ted Abernathy | Third | 15½ out |
| » Defeated Athletics (49-104), 6-2 | Shibe Park (7-3) | 81-71 | Won 2 |
| » Starters: Al Smith vs Charlie Bowles | Third | 15½ out |
| Sunday, October 3 |
| » Defeated Athletics (49-105), 8-4 | Shibe Park (8-3) | 82-71 | Won 3 |
| » Starters: Mel Harder vs Norm Brown | Third | 15½ out |
| Thursday, October 7 |
| Future Indian Jose Cardenal is born in Matanzas, Cuba. |
| Tuesday, October 19 |
| Future Indian Sandy Alomar Jr. is born in Salinas, P.R. |
| Friday, December 3 |
| Future Indian Jerry Johnson is born in Miami, FL. |
| Sunday, December 19 |
| Future Indian Walt Williams is born in Brownwood, TX. |
Game information provided by Retrosheet (www.retrosheet.org) |
