| Sunday, February 8 |
| Future Indian Fritz Peterson is born in Chicago, IL. |
| Thursday, February 12 |
| Future Indian Pat Dobson is born in Depew, NY. |
| Tuesday, March 10 |
| Future Indian Tom Hilgendorf is born in Clinton, IA. |
| Tuesday, April 14 |
| » Defeated Tigers (0-1), 5-2 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Jim Bagby vs Al Benton | First | -- |
| » Major-league debuts: Billy Hitchcock (Tigers) |
| Wednesday, April 15 |
| » Lost to Tigers (1-1), 6-2 | Tiger Stadium (1-1) | 1-1 | |
| » Starters: Ray Poat vs Dizzy Trout | Second | 1 out |
| » Major-league debuts: Ray Poat (Indians) |
| Thursday, April 16 |
| » Lost to Tigers (2-1), 5-4 | Tiger Stadium (1-2) | 1-2 | Lost 2 |
| » Starters: Al Milnar vs Tommy Bridges | Third | 2 out |
| Friday, April 17 |
| » Lost to White Sox (1-3), 1-0 | Cleveland Stadium (0-1) | 1-3 | Lost 3 |
| » Starters: Ted Lyons vs Mel Harder | Fourth | 3 out |
| Saturday, April 18 |
| » Defeated White Sox (1-4), 1-0 | Cleveland Stadium (1-1) | 2-3 | |
| » Starters: Eddie Smith vs Jim Bagby | Third | 2 out |
| Monday, April 20 |
| » Defeated Browns (5-3), 4-3 | League Park II (1-0) | 3-3 | Won 2 |
| » Starters: Denny Galehouse vs Al Smith | Fourth | 1½ out |
| Tuesday, April 21 |
| » Defeated Browns (5-4), 4-2 | League Park II (2-0) | 4-3 | Won 3 |
| » Starters: Bob Harris vs Al Milnar | Second | 1 out |
| Wednesday, April 22 |
| » Defeated Browns (5-5), 3-2 | League Park II (3-0) | 5-3 | Won 4 |
| » Starters: Bob Muncrief vs Vern Kennedy | Second | 1 out |
| Thursday, April 23 |
| » Defeated Browns (5-6), 9-2 | Sportsman's Park III (1-0) | 6-3 | Won 5 |
| » Starters: Jim Bagby vs Elden Auker | Second | 1 out |
| Friday, April 24 |
| » Defeated Browns (5-7), 2-0 | Sportsman's Park III (2-0) | 7-3 | Won 6 |
| » Starters: Mel Harder vs Denny Galehouse | Second | 1 out |
| Saturday, April 25 |
| » Defeated White Sox (3-8), 5-4 | Comiskey Park I (1-0) | 8-3 | Won 7 |
| » Starters: Al Milnar vs Johnny Humphries | First | -- |
| Sunday, April 26 |
| » Defeated White Sox (3-9), 3-2 | Comiskey Park I (2-0) | 9-3 | Won 8 |
| » Starters: Al Smith vs Johnny Rigney | First | -- |
| Tuesday, April 28 |
| » Defeated Athletics (5-10), 6-4 | Shibe Park (1-0) | 10-3 | Won 9 |
| » Starters: Jim Bagby vs Jack Knott | First | -- |
| Wednesday, April 29 |
| » Defeated Athletics (5-11), 11-6 | Shibe Park (2-0) | 11-3 | Won 10 |
| » Starters: Al Milnar vs Phil Marchildon | First | -- |
| Thursday, April 30 |
| » Defeated Athletics (5-12), 6-1 | Shibe Park (3-0) | 12-3 | Won 11 |
| » Starters: Vern Kennedy vs Herman Besse | First | -- |
| Friday, May 1 |
| » Defeated Senators (8-10), 13-6 | Griffith Stadium (1-0) | 13-3 | Won 12 |
| » Starters: Mel Harder vs Bill Kennedy | First | -- |
| » Major-league debuts: Bill Kennedy (Senators) |
| Saturday, May 2 |
| » Defeated Senators (8-11), 12-3 | Griffith Stadium (2-0) | 14-3 | Won 13 |
| » Starters: Jim Bagby vs Bobo Newsom | First | -- |
| Sunday, May 3 |
| » Lost to Red Sox (11-7), 8-4 | Fenway Park (0-1) | 14-4 | |
| » Starters: Al Smith vs Charlie Wagner | First | -- |
| Monday, May 4 |
| » Lost to Red Sox (12-7), 11-8 | Fenway Park (0-2) | 14-5 | Lost 2 |
| » Starters: Al Milnar vs Dick Newsome | First | -- |
| Tuesday, May 5 |
| » Lost to Red Sox (13-7), 13-3 | Fenway Park (0-3) | 14-6 | Lost 3 |
| » Starters: Vern Kennedy vs Ken Chase | First | -- |
| Wednesday, May 6 |
| » Lost to Yankees (15-7), 3-0 | Yankee Stadium (0-1) | 14-7 | Lost 4 |
| » Starters: Jim Bagby vs Tiny Bonham | Second | ½ out |
| Saturday, May 9 |
| » Lost to Tigers (16-10), 1-0 | Tiger Stadium (1-3) | 14-8 | Lost 5 |
| » Starters: Mel Harder vs Al Benton | Second | 1 out |
| Sunday, May 10 |
| » Lost to Tigers (17-10), 5-1 | Cleveland Stadium (1-2) | 14-9 | Lost 6 |
| » Starters: Tommy Bridges vs Al Smith | Second | 2 out |
| » Defeated Tigers (17-11), 6-5 | Cleveland Stadium (2-2) | 15-9 | |
| » Starters: Hal White vs Jim Bagby | Second | 2 out |
| Monday, May 11 |
| » Defeated Tigers (17-12), 8-5 | League Park II (4-0) | 16-9 | Won 2 |
| » Starters: Dizzy Trout vs Vern Kennedy | Second | 1½ out |
| Wednesday, May 13 |
| » Defeated Yankees (17-8), 7-2 | League Park II (5-0) | 17-9 | Won 3 |
| » Starters: Lefty Gomez vs Chubby Dean | Second | ½ out |
| Saturday, May 16 |
| » Defeated Senators (11-16), 5-4 | League Park II (6-0) | 18-9 | Won 4 |
| » Starters: Early Wynn vs Al Smith | Second | 1½ out |
| » Lost to Senators (12-16), 7-1 | League Park II (6-1) | 18-10 | |
| » Starters: Sid Hudson vs Harry Eisenstat | Second | 1½ out |
| Sunday, May 17 |
| » Defeated Athletics (13-19), 4-1 | Cleveland Stadium (3-2) | 19-10 | |
| » Starters: Roger Wolff vs Jim Bagby | Second | ½ out |
| » Defeated Athletics (13-20), 9-3 | Cleveland Stadium (4-2) | 20-10 | Won 2 |
| » Starters: Russ Christopher vs Al Milnar | Second | ½ out |
| Monday, May 18 |
| » Defeated Athletics (13-21), 7-4 | League Park II (7-1) | 21-10 | Won 3 |
| » Starters: Herman Besse vs Chubby Dean | Second | 1 out |
| Tuesday, May 19 |
| » Defeated Athletics (13-22), 4-1 | League Park II (8-1) | 22-10 | Won 4 |
| » Starters: Dick Fowler vs Red Embree | Second | 1½ out |
| Thursday, May 21 |
| » Lost to Red Sox (17-14), 8-3 | League Park II (8-2) | 22-11 | |
| » Starters: Tex Hughson vs Mel Harder | Second | 1 out |
| Saturday, May 23 |
| » Lost to Browns (15-21), 2-1 | Cleveland Stadium (4-3) | 22-12 | Lost 2 |
| » Starters: Johnny Niggeling vs Jim Bagby | Second | 2 out |
| Sunday, May 24 |
| » Lost to Browns (16-21), 3-2 | Cleveland Stadium (4-4) | 22-13 | Lost 3 |
| » Starters: Elden Auker vs Al Smith | Second | 2½ out |
| » Lost to Browns (17-21), 4-1 | Cleveland Stadium (4-5) | 22-14 | Lost 4 |
| » Starters: Denny Galehouse vs Al Milnar | Second | 2½ out |
| Monday, May 25 |
| » Lost to White Sox (14-23), 5-1 | League Park II (8-3) | 22-15 | Lost 5 |
| » Starters: Bill Dietrich vs Chubby Dean | Second | 3½ out |
| Former Indian Bill James dies in Venice, CA at the age of 56. |
| Tuesday, May 26 |
| » Defeated White Sox (14-24), 2-1 | Cleveland Stadium (5-5) | 23-15 | |
| » Starters: Eddie Smith vs Mel Harder | Second | 3½ out |
| Wednesday, May 27 |
| » Lost to White Sox (15-24), 9-7 | League Park II (8-4) | 23-16 | |
| » Starters: Johnny Humphries vs Jim Bagby | Second | 4½ out |
| Thursday, May 28 |
| » Lost to Tigers (24-20), 6-2 | Tiger Stadium (1-4) | 23-17 | Lost 2 |
| » Starters: Al Milnar vs Virgil Trucks | Second | 5½ out |
| Future Indian Buddy Booker is born in Lynchburg, VA. |
| Friday, May 29 |
| » Lost to Tigers (25-20), 14-3 | Tiger Stadium (1-5) | 23-18 | Lost 3 |
| » Starters: Al Smith vs Hal White | Second | 6½ out |
| Saturday, May 30 |
| » Defeated Browns (20-24), 5-4 | Cleveland Stadium (6-5) | 24-18 | |
| » Starters: Bob Muncrief vs Chubby Dean | Second | 7½ out |
| » Lost to Browns (21-24), 2-0 | Cleveland Stadium (6-6) | 24-19 | |
| » Starters: Al Hollingsworth vs Red Embree | Second | 7½ out |
| Sunday, May 31 |
| » Lost to Browns (22-24), 5-4 | Sportsman's Park III (2-1) | 24-20 | Lost 2 |
| » Starters: Jim Bagby vs Elden Auker | Fourth | 8½ out |
| » Lost to Browns (23-24), 8-3 | Sportsman's Park III (2-2) | 24-21 | Lost 3 |
| » Starters: Vern Kennedy vs Johnny Niggeling | Fourth | 8½ out |
| Tuesday, June 2 |
| » Defeated Red Sox (23-21), 7-2 | Fenway Park (1-3) | 25-21 | |
| » Starters: Mel Harder vs Charlie Wagner | Third | 8 out |
| Thursday, June 4 |
| » Defeated Red Sox (23-22), 4-2 | Fenway Park (2-3) | 26-21 | Won 2 |
| » Starters: Jim Bagby vs Oscar Judd | Second | 8½ out |
| Friday, June 5 |
| » Lost to Yankees (34-11), 6-3 | Yankee Stadium (0-2) | 26-22 | |
| » Starters: Al Smith vs Lefty Gomez | Second | 9½ out |
| Saturday, June 6 |
| » Lost to Yankees (35-11), 3-0 | Yankee Stadium (0-3) | 26-23 | Lost 2 |
| » Starters: Chubby Dean vs Red Ruffing | Third | 10½ out |
| Sunday, June 7 |
| » Defeated Yankees (35-12), 5-4 | Yankee Stadium (1-3) | 27-23 | |
| » Starters: Joe Heving vs Tiny Bonham | Fourth | 10½ out |
| » Lost to Yankees (36-12), 13-1 | Yankee Stadium (1-4) | 27-24 | |
| » Starters: Mel Harder vs Spud Chandler | Fourth | 10½ out |
| Monday, June 8 |
| » Lost to Yankees (37-12), 11-10 | Yankee Stadium (1-5) | 27-25 | Lost 2 |
| » Starters: Jim Bagby vs Atley Donald | Fifth | 11½ out |
| Tuesday, June 9 |
| » Defeated Senators (21-32), 7-6 | Griffith Stadium (3-0) | 28-25 | |
| » Starters: Red Embree vs Sid Hudson | Third | 11½ out |
| Wednesday, June 10 |
| » Defeated Senators (21-33), 4-3 | Griffith Stadium (4-0) | 29-25 | Won 2 |
| » Starters: Jim Bagby vs Bobo Newsom | Third | 10½ out |
| Thursday, June 11 |
| » Defeated Senators (21-34), 8-6 | Griffith Stadium (5-0) | 30-25 | Won 3 |
| » Starters: Chubby Dean vs Early Wynn | Third | 10 out |
| Friday, June 12 |
| » Lost to Athletics (23-36), 5-4 | Shibe Park (3-1) | 30-26 | |
| » Starters: Al Milnar vs Dick Fowler | Third | 10½ out |
| Saturday, June 13 |
| » Lost to Athletics (24-36), 4-1 | Shibe Park (3-2) | 30-27 | Lost 2 |
| » Starters: Mel Harder vs Roger Wolff | Third | 11½ out |
| Sunday, June 14 |
| » Defeated Athletics (24-37), 8-3 | Shibe Park (4-2) | 31-27 | |
| » Starters: Al Smith vs Phil Marchildon | Third | 12½ out |
| » Lost to Athletics (25-37), 5-1 | Shibe Park (4-3) | 31-28 | |
| » Starters: Red Embree vs Lum Harris | Third | 12½ out |
| Wednesday, June 17 |
| » Defeated Senators (22-37), 5-4 | Cleveland Stadium (7-6) | 32-28 | |
| » Starters: Bobo Newsom vs Jim Bagby | Third | 11½ out |
| Thursday, June 18 |
| » Lost to Senators (23-37), 7-1 | Cleveland Stadium (7-7) | 32-29 | |
| » Starters: Early Wynn vs Vern Kennedy | Third | 11½ out |
| Friday, June 19 |
| » Defeated Yankees (42-17), 5-4 | Cleveland Stadium (8-7) | 33-29 | |
| » Starters: Lefty Gomez vs Mel Harder | Third | 10½ out |
| Saturday, June 20 |
| » Defeated Yankees (42-18), 1-0 | Cleveland Stadium (9-7) | 34-29 | Won 2 |
| » Starters: Tiny Bonham vs Al Smith | Third | 9½ out |
| Sunday, June 21 |
| » Defeated Yankees (42-19), 3-2 | Cleveland Stadium (10-7) | 35-29 | Won 3 |
| » Starters: Red Ruffing vs Chubby Dean | Third | 9½ out |
| » Lost to Yankees (43-19), 4-0 | Cleveland Stadium (10-8) | 35-30 | |
| » Starters: Hank Borowy vs Red Embree | Third | 9½ out |
| Tuesday, June 23 |
| » Defeated Athletics (28-42), 7-5 | League Park II (9-4) | 36-30 | |
| » Starters: Bob Harris vs Jim Bagby | Third | 9½ out |
| Wednesday, June 24 |
| » Defeated Athletics (28-43), 9-0 | League Park II (10-4) | 37-30 | Won 2 |
| » Starters: Dick Fowler vs Al Milnar | Third | 9½ out |
| Thursday, June 25 |
| » Defeated Athletics (28-44), 4-1 | League Park II (11-4) | 38-30 | Won 3 |
| » Starters: Roger Wolff vs Al Smith | Third | 9 out |
| Friday, June 26 |
| » Lost to Red Sox (38-26), 3-2 | Cleveland Stadium (10-9) | 38-31 | |
| » Starters: Dick Newsome vs Mel Harder | Third | 9 out |
| Saturday, June 27 |
| » Lost to Red Sox (39-26), 6-3 | Cleveland Stadium (10-10) | 38-32 | Lost 2 |
| » Starters: Ken Chase vs Chubby Dean | Third | 10 out |
| Sunday, June 28 |
| » Lost to Red Sox (40-26), 8-3 | Cleveland Stadium (10-11) | 38-33 | Lost 3 |
| » Starters: Oscar Judd vs Jim Bagby | Third | 9 out |
| » Defeated Red Sox (40-27), 3-2 | Cleveland Stadium (11-11) | 39-33 | |
| » Starters: Charlie Wagner vs Vern Kennedy | Third | 9 out |
| Monday, June 29 |
| » Defeated White Sox (30-38), 11-5 | Comiskey Park I (3-0) | 40-33 | Won 2 |
| » Starters: Al Milnar vs Buck Ross | Third | 8½ out |
| Tuesday, June 30 |
| » Defeated White Sox (30-39), 3-1 | Comiskey Park I (4-0) | 41-33 | Won 3 |
| » Starters: Jim Bagby vs Eddie Smith | Third | 8 out |
| Wednesday, July 1 |
| » Defeated White Sox (30-40), 7-2 | Comiskey Park I (5-0) | 42-33 | Won 4 |
| » Starters: Al Smith vs Orval Grove | Third | 7 out |
| Thursday, July 2 |
| » Defeated White Sox (30-41), 7-5 | Comiskey Park I (6-0) | 43-33 | Won 5 |
| » Starters: Chubby Dean vs Johnny Humphries | Third | 6½ out |
| Friday, July 3 |
| » Lost to Tigers (43-36), 5-1 | Cleveland Stadium (11-12) | 43-34 | |
| » Starters: Hal Newhouser vs Mel Harder | Third | 7½ out |
| Saturday, July 4 |
| » Defeated Tigers (43-37), 10-3 | Cleveland Stadium (12-12) | 44-34 | |
| » Starters: Tommy Bridges vs Al Milnar | Third | 7 out |
| » Tied Tigers, 3-3 | Cleveland Stadium (12-12) | 44-34 | |
| » Starters: Roy Henshaw vs Jim Bagby | Third | 7 out |
| Sunday, July 5 |
| » Lost to Tigers (44-37), 10-1 | Tiger Stadium (1-6) | 44-35 | |
| » Starters: Vern Kennedy vs Dizzy Trout | Third | 7 out |
| » Defeated Tigers (44-38), 5-1 | Tiger Stadium (2-6) | 45-35 | |
| » Starters: Mel Harder vs Hal White | Third | 7 out |
| Thursday, July 9 |
| » Lost to Athletics (34-51), 5-2 | Shibe Park (4-4) | 45-36 | |
| » Starters: Chubby Dean vs Phil Marchildon | Third | 8 out |
| Friday, July 10 |
| » Defeated Athletics (34-52), 4-2 | Shibe Park (5-4) | 46-36 | |
| » Starters: Mel Harder vs Herman Besse | Third | 8 out |
| Saturday, July 11 |
| » Defeated Athletics (34-53), 3-1 | Shibe Park (6-4) | 47-36 | Won 2 |
| » Starters: Vern Kennedy vs Russ Christopher | Third | 7 out |
| Sunday, July 12 |
| » Defeated Senators (29-53), 9-7 | Griffith Stadium (6-0) | 48-36 | Won 3 |
| » Starters: Al Smith vs Sid Hudson | Third | 6 out |
| » Defeated Senators (29-54), 5-0 | Griffith Stadium (7-0) | 49-36 | Won 4 |
| » Starters: Jim Bagby vs Bobo Newsom | Third | 6 out |
| Monday, July 13 |
| » Lost to Senators (30-54), 7-0 | Griffith Stadium (7-1) | 49-37 | |
| » Starters: Al Milnar vs Walt Masterson | Third | 7 out |
| Wednesday, July 15 |
| » Lost to Yankees (56-28), 4-0 | Yankee Stadium (1-6) | 49-38 | Lost 2 |
| » Starters: Chubby Dean vs Atley Donald | Third | 8½ out |
| Thursday, July 16 |
| » Lost to Yankees (57-28), 8-5 | Yankee Stadium (1-7) | 49-39 | Lost 3 |
| » Starters: Mel Harder vs Tiny Bonham | Third | 9½ out |
| Friday, July 17 |
| » Lost to Yankees (58-28), 8-1 | Yankee Stadium (1-8) | 49-40 | Lost 4 |
| » Starters: Al Smith vs Spud Chandler | Third | 10½ out |
| Sunday, July 19 |
| » Defeated Red Sox (50-36), 10-7 | Fenway Park (3-3) | 50-40 | |
| » Starters: Jim Bagby vs Tex Hughson | Third | 11 out |
| » Defeated Red Sox (50-37), 4-0 | Fenway Park (4-3) | 51-40 | Won 2 |
| » Starters: Mel Harder vs Oscar Judd | Third | 11 out |
| Tuesday, July 21 |
| » Lost to Yankees (62-28), 8-3 | Cleveland Stadium (12-13) | 51-41 | |
| » Starters: Lefty Gomez vs Al Smith | Third | 12 out |
| Wednesday, July 22 |
| » Lost to Yankees (63-28), 5-1 | League Park II (11-5) | 51-42 | Lost 2 |
| » Starters: Atley Donald vs Al Milnar | Third | 13 out |
| Thursday, July 23 |
| » Defeated Yankees (63-29), 3-2 | League Park II (12-5) | 52-42 | |
| » Starters: Tiny Bonham vs Chubby Dean | Third | 12 out |
| Friday, July 24 |
| » Defeated Senators (36-58), 4-3 | Cleveland Stadium (13-13) | 53-42 | Won 2 |
| » Starters: Early Wynn vs Jim Bagby | Third | 11½ out |
| » Defeated Senators (36-59), 5-4 | Cleveland Stadium (14-13) | 54-42 | Won 3 |
| » Starters: Walt Masterson vs Mel Harder | Third | 11½ out |
| Saturday, July 25 |
| » Lost to Senators (37-59), 10-6 | Cleveland Stadium (14-14) | 54-43 | |
| » Starters: Bobo Newsom vs Al Smith | Third | 12½ out |
| Sunday, July 26 |
| » Lost to Senators (38-59), 2-0 | Cleveland Stadium (14-15) | 54-44 | Lost 2 |
| » Starters: Sid Hudson vs Vern Kennedy | Third | 13 out |
| » Defeated Senators (38-60), 7-1 | Cleveland Stadium (15-15) | 55-44 | |
| » Starters: Early Wynn vs Al Smith | Third | 13 out |
| Monday, July 27 |
| » Lost to Red Sox (54-42), 8-5 | League Park II (12-6) | 55-45 | |
| » Starters: Tex Hughson vs Al Milnar | Third | 13½ out |
| Tuesday, July 28 |
| » Lost to Red Sox (55-42), 3-1 | Cleveland Stadium (15-16) | 55-46 | Lost 2 |
| » Starters: Joe Dobson vs Jim Bagby | Third | 14½ out |
| Wednesday, July 29 |
| » Defeated Red Sox (55-43), 7-6 | League Park II (13-6) | 56-46 | |
| » Starters: Ken Chase vs Chubby Dean | Third | 13 out |
| Thursday, July 30 |
| » Defeated Red Sox (55-44), 4-3 | League Park II (14-6) | 57-46 | Won 2 |
| » Starters: Oscar Judd vs Mel Harder | Third | 12½ out |
| Friday, July 31 |
| » Lost to Athletics (42-65), 6-4 | Cleveland Stadium (15-17) | 57-47 | |
| » Starters: Dick Fowler vs Al Smith | Third | 13 out |
| Sunday, August 2 |
| » Defeated Athletics (42-66), 4-3 | Cleveland Stadium (16-17) | 58-47 | |
| » Starters: Jack Knott vs Al Milnar | Second | 12½ out |
| » Defeated Athletics (42-67), 4-2 | Cleveland Stadium (17-17) | 59-47 | Won 2 |
| » Starters: Russ Christopher vs Jim Bagby | Second | 12½ out |
| Wednesday, August 5 |
| » Defeated Browns (54-54), 8-5 | Sportsman's Park III (3-2) | 60-47 | Won 3 |
| » Starters: Chubby Dean vs Denny Galehouse | Second | 11½ out |
| Sunday, August 9 |
| » Lost to White Sox (47-55), 11-1 | Comiskey Park I (6-1) | 60-48 | |
| » Starters: Mel Harder vs Ted Lyons | Third | 12½ out |
| » Lost to White Sox (48-55), 3-2 | Comiskey Park I (6-2) | 60-49 | Lost 2 |
| » Starters: Jim Bagby vs Bill Dietrich | Third | 12½ out |
| Future Indian Tommie Agee is born in Magnolia, AL. |
| Monday, August 10 |
| » Lost to White Sox (49-55), 3-1 | Comiskey Park I (6-3) | 60-50 | Lost 3 |
| » Starters: Chubby Dean vs Johnny Humphries | Third | 13 out |
| Tuesday, August 11 |
| » Tied Tigers, 0-0 | Cleveland Stadium (17-17) | 60-50 | |
| » Starters: Tommy Bridges vs Al Milnar | Third | 13 out |
| » Lost to Tigers (54-60), 3-2 | Cleveland Stadium (17-18) | 60-51 | Lost 4 |
| » Starters: Dizzy Trout vs Mel Harder | Third | 13 out |
| Wednesday, August 12 |
| » Lost to Tigers (55-60), 4-2 | League Park II (14-7) | 60-52 | Lost 5 |
| » Starters: Al Benton vs Al Smith | Third | 14½ out |
| » Lost to Tigers (56-60), 2-0 | League Park II (14-8) | 60-53 | Lost 6 |
| » Starters: Hal Newhouser vs Joe Heving | Third | 14½ out |
| Thursday, August 13 |
| » Defeated Tigers (56-61), 3-2 | League Park II (15-8) | 61-53 | |
| » Starters: Virgil Trucks vs Jim Bagby | Third | 14 out |
| Saturday, August 15 |
| Future Indian Cap Peterson is born in Tacoma, WA. |
| Sunday, August 16 |
| » Defeated Browns (59-57), 3-2 | Cleveland Stadium (18-18) | 62-53 | Won 2 |
| » Starters: Elden Auker vs Chubby Dean | Third | 15 out |
| » Lost to Browns (60-57), 6-1 | Cleveland Stadium (18-19) | 62-54 | |
| » Starters: Denny Galehouse vs Al Milnar | Third | 15 out |
| Monday, August 17 |
| » Lost to Browns (61-57), 5-2 | Cleveland Stadium (18-20) | 62-55 | Lost 2 |
| » Starters: Johnny Niggeling vs Mel Harder | Third | 16 out |
| Wednesday, August 19 |
| » Lost to Tigers (60-62), 6-1 | Tiger Stadium (2-7) | 62-56 | Lost 3 |
| » Starters: Jim Bagby vs Virgil Trucks | Third | 16 out |
| Friday, August 21 |
| » Defeated White Sox (51-63), 3-2 | Cleveland Stadium (19-20) | 63-56 | |
| » Starters: Thornton Lee vs Mel Harder | Third | 15½ out |
| Saturday, August 22 |
| » Lost to White Sox (52-63), 3-1 | Cleveland Stadium (19-21) | 63-57 | |
| » Starters: Eddie Smith vs Chubby Dean | Third | 16½ out |
| Sunday, August 23 |
| » Lost to White Sox (53-63), 3-1 | Cleveland Stadium (19-22) | 63-58 | Lost 2 |
| » Starters: Ted Lyons vs Al Smith | Third | 16½ out |
| » Defeated White Sox (53-64), 1-0 | Cleveland Stadium (20-22) | 64-58 | |
| » Starters: Jake Wade vs Jim Bagby | Third | 16½ out |
| Tuesday, August 25 |
| » Lost to Red Sox (73-51), 4-3 | Fenway Park (4-4) | 64-59 | |
| » Starters: Tom Ferrick vs Ken Chase | Fourth | 18 out |
| » Lost to Red Sox (74-51), 5-1 | Fenway Park (4-5) | 64-60 | Lost 2 |
| » Starters: Vern Kennedy vs Oscar Judd | Fourth | 18 out |
| Wednesday, August 26 |
| » Lost to Red Sox (75-51), 4-1 | Fenway Park (4-6) | 64-61 | Lost 3 |
| » Starters: Mel Harder vs Bill Butland | Fourth | 18 out |
| Thursday, August 27 |
| » Defeated Red Sox (75-52), 4-2 | Fenway Park (5-6) | 65-61 | |
| » Starters: Jim Bagby vs Tex Hughson | Fourth | 17½ out |
| Friday, August 28 |
| » Lost to Yankees (83-43), 3-0 | Yankee Stadium (1-9) | 65-62 | |
| » Starters: Chubby Dean vs Spud Chandler | Fourth | 18½ out |
| Saturday, August 29 |
| » Defeated Yankees (83-44), 6-5 | Yankee Stadium (2-9) | 66-62 | |
| » Starters: Al Smith vs Tiny Bonham | Fourth | 17½ out |
| Sunday, August 30 |
| » Defeated Senators (49-75), 3-1 | Griffith Stadium (8-1) | 67-62 | Won 2 |
| » Starters: Al Milnar vs Sid Hudson | Fourth | 18½ out |
| » Lost to Senators (50-75), 2-0 | Griffith Stadium (8-2) | 67-63 | |
| » Starters: Mel Harder vs Dutch Leonard | Fourth | 18½ out |
| Tuesday, September 1 |
| » Lost to Senators (51-75), 4-3 | Griffith Stadium (8-3) | 67-64 | Lost 2 |
| » Starters: Jim Bagby vs Alex Carrasquel | Fourth | 19½ out |
| Wednesday, September 2 |
| » Defeated Athletics (49-89), 12-3 | Shibe Park (7-4) | 68-64 | |
| » Starters: Tom Ferrick vs Herman Besse | Fourth | 20 out |
| Friday, September 4 |
| » Lost to Browns (69-63), 6-3 | Sportsman's Park III (3-3) | 68-65 | |
| » Starters: Chubby Dean vs Al Hollingsworth | Fourth | 21 out |
| » Lost to Browns (70-63), 4-0 | Sportsman's Park III (3-4) | 68-66 | Lost 2 |
| » Starters: Mel Harder vs Johnny Niggeling | Fourth | 21 out |
| Saturday, September 5 |
| » Lost to Browns (71-63), 6-2 | Sportsman's Park III (3-5) | 68-67 | Lost 3 |
| » Starters: Vern Kennedy vs Fritz Ostermueller | Fourth | 22 out |
| » Lost to Browns (72-63), 4-3 | Sportsman's Park III (3-6) | 68-68 | Lost 4 |
| » Starters: Al Smith vs Steve Sundra | Fourth | 22 out |
| Sunday, September 6 |
| » Lost to Browns (73-63), 3-2 | Sportsman's Park III (3-7) | 68-69 | Lost 5 |
| » Starters: Jim Bagby vs Denny Galehouse | Fourth | 23 out |
| » Defeated Browns (73-64), 6-5 | Sportsman's Park III (4-7) | 69-69 | |
| » Starters: Mel Harder vs Stan Ferens | Fourth | 23 out |
| Tuesday, September 8 |
| » Defeated White Sox (59-73), 10-0 | Comiskey Park I (7-3) | 70-69 | Won 2 |
| » Starters: Ray Poat vs Thornton Lee | Fourth | 23½ out |
| Future Indian Steve Hargan is born in Fort Wayne, IN. |
| Wednesday, September 9 |
| » Lost to Athletics (51-92), 5-4 | Cleveland Stadium (20-23) | 70-70 | |
| » Starters: Bob Harris vs Red Embree | Fourth | 24½ out |
| » Major-league debuts: Eddie Robinson and Ted Sepkowski (Indians) |
| Friday, September 11 |
| » Lost to Red Sox (85-56), 15-2 | League Park II (15-9) | 70-71 | Lost 2 |
| » Starters: Ken Chase vs Jim Bagby | Fourth | 24 out |
| Saturday, September 12 |
| » Lost to Red Sox (86-56), 8-6 | League Park II (15-10) | 70-72 | Lost 3 |
| » Starters: Joe Dobson vs Mel Harder | Fourth | 25 out |
| Sunday, September 13 |
| » Lost to Yankees (96-47), 9-1 | Cleveland Stadium (20-24) | 70-73 | Lost 4 |
| » Starters: Red Ruffing vs Ray Poat | Fourth | 27 out |
| » Lost to Yankees (97-47), 4-1 | Cleveland Stadium (20-25) | 70-74 | Lost 5 |
| » Starters: Hank Borowy vs Chubby Dean | Fourth | 27 out |
| Monday, September 14 |
| » Lost to Yankees (98-47), 8-3 | League Park II (15-11) | 70-75 | Lost 6 |
| » Starters: Tiny Bonham vs Al Smith | Fourth | 28 out |
| Wednesday, September 16 |
| » Defeated Senators (59-85), 5-1 | League Park II (16-11) | 71-75 | |
| » Starters: Bill Kennedy vs Jim Bagby | Fourth | 28 out |
| Thursday, September 17 |
| » Defeated Senators (59-86), 6-5 | League Park II (17-11) | 72-75 | Won 2 |
| » Starters: Ray Scarborough vs Chubby Dean | Fourth | 28 out |
| » Major-league debuts: Allie Reynolds (Indians) |
| Saturday, September 19 |
| » Major-league debuts: Joe Coleman (Athletics) |
| Sunday, September 20 |
| » Defeated Tigers (70-79), 2-0 | Tiger Stadium (3-7) | 73-75 | Won 3 |
| » Starters: Mel Harder vs Al Benton | Fourth | 27½ out |
| » Lost to Tigers (71-79), 6-5 | Tiger Stadium (3-8) | 73-76 | |
| » Starters: Jim Bagby vs Hal White | Fourth | 27½ out |
| Monday, September 21 |
| Future Indian Sam McDowell is born in Pittsburgh, PA. |
| Thursday, September 24 |
| » Lost to White Sox (64-82), 3-1 | League Park II (17-12) | 73-77 | Lost 2 |
| » Starters: Ted Lyons vs Al Smith | Fourth | 29 out |
| » Lost to White Sox (65-82), 4-2 | League Park II (17-13) | 73-78 | Lost 3 |
| » Starters: Eddie Smith vs Ray Poat | Fourth | 29 out |
| » Major-league debuts: Paul Calvert (Indians) |
| Friday, September 25 |
| » Lost to White Sox (66-82), 8-1 | League Park II (17-14) | 73-79 | Lost 4 |
| » Starters: Thornton Lee vs Chubby Dean | Fourth | 29½ out |
| Saturday, September 26 |
| » Defeated Tigers (73-80), 3-0 | League Park II (18-14) | 74-79 | |
| » Starters: Al Benton vs Mel Harder | Fourth | 29 out |
| Sunday, September 27 |
| » Defeated Tigers (73-81), 8-0 | Cleveland Stadium (21-25) | 75-79 | Won 2 |
| » Starters: Tommy Bridges vs Jim Bagby | Fourth | 28 out |
| Sunday, October 18 |
| Future Indian Willie Horton is born in Arno, VA. |
| Thursday, October 22 |
| Future Indian Cecil Upshaw is born in Spearsville, LA. |
| Thursday, November 5 |
| Future Indian Richie Scheinblum is born in New York, NY. |
| Tuesday, November 24 |
| Future Indian Fred Beene is born in Angleton, TX. |
| Sunday, November 29 |
| Former Indian Bob Bescher dies in London, OH at the age of 59. |
| Monday, December 7 |
| Future Indian Alex Johnson is born in Helena, AR. |
Game information provided by Retrosheet (www.retrosheet.org) |
