| Monday, January 20 |
| Former Indian Jack Lelivelt dies in Seattle, WA at the age of 56. |
| Wednesday, March 5 |
| Future Indian Phil Roof is born in Paducah, KY. |
| Monday, April 14 |
| » Major-league debuts: Phil Rizzuto and Johnny Sturm (Yankees) |
| Tuesday, April 15 |
| » Lost to White Sox (1-0), 4-3 | Cleveland Stadium (0-1) | 0-1 | |
| » Starters: Bill Dietrich vs Bob Feller | Fourth | 1 out |
| Wednesday, April 16 |
| » Defeated White Sox (1-1), 6-0 | League Park II (1-0) | 1-1 | |
| » Starters: Eddie Smith vs Al Milnar | Third | 1 out |
| Thursday, April 17 |
| » Defeated White Sox (1-2), 2-0 | League Park II (2-0) | 2-1 | Won 2 |
| » Starters: Thornton Lee vs Al Smith | Third | ½ out |
| Friday, April 18 |
| » Lost to Tigers (1-1), 4-2 | Tiger Stadium (0-1) | 2-2 | |
| » Starters: Jim Bagby vs Tommy Bridges | Third | 1½ out |
| Saturday, April 19 |
| » Defeated Tigers (1-2), 2-1 | Tiger Stadium (1-1) | 3-2 | |
| » Starters: Bob Feller vs Johnny Gorsica | Second | 1½ out |
| Sunday, April 20 |
| » Defeated Tigers (1-3), 4-2 | Tiger Stadium (2-1) | 4-2 | Won 2 |
| » Starters: Mel Harder vs Schoolboy Rowe | Second | 1½ out |
| Tuesday, April 22 |
| » Lost to Browns (2-1), 6-3 | League Park II (2-1) | 4-3 | |
| » Starters: Elden Auker vs Al Milnar | Fourth | 1 out |
| Wednesday, April 23 |
| » Defeated Browns (2-2), 5-2 | League Park II (3-1) | 5-3 | |
| » Starters: Johnny Niggeling vs Bob Feller | First | -- |
| Thursday, April 24 |
| » Lost to White Sox (4-3), 2-1 | Comiskey Park I (0-1) | 5-4 | |
| » Starters: Al Smith vs Thornton Lee | Third | 1 out |
| Friday, April 25 |
| » Defeated White Sox (4-4), 5-3 | Comiskey Park I (1-1) | 6-4 | |
| » Starters: Jim Bagby vs Ted Lyons | Second | 1 out |
| Saturday, April 26 |
| » Defeated Tigers (4-5), 6-3 | League Park II (4-1) | 7-4 | Won 2 |
| » Starters: Bobo Newsom vs Mel Harder | Second | 1 out |
| Sunday, April 27 |
| » Defeated Tigers (4-6), 2-1 | Cleveland Stadium (1-1) | 8-4 | Won 3 |
| » Starters: Schoolboy Rowe vs Bob Feller | First | -- |
| Monday, April 28 |
| » Defeated Tigers (4-7), 7-2 | League Park II (5-1) | 9-4 | Won 4 |
| » Starters: Hal Newhouser vs Al Milnar | First | -- |
| Tuesday, April 29 |
| » Defeated Athletics (4-8), 8-3 | League Park II (6-1) | 10-4 | Won 5 |
| » Starters: Chubby Dean vs Al Smith | First | -- |
| Wednesday, April 30 |
| » Defeated Athletics (4-9), 6-5 | League Park II (7-1) | 11-4 | Won 6 |
| » Starters: Les McCrabb vs Jim Bagby | First | -- |
| Thursday, May 1 |
| » Defeated Athletics (4-10), 13-8 | League Park II (8-1) | 12-4 | Won 7 |
| » Starters: Jack Knott vs Bob Feller | First | -- |
| Friday, May 2 |
| » Defeated Red Sox (8-7), 7-3 | League Park II (9-1) | 13-4 | Won 8 |
| » Starters: Dick Newsome vs Mel Harder | First | -- |
| Saturday, May 3 |
| » Defeated Red Sox (8-8), 4-2 | League Park II (10-1) | 14-4 | Won 9 |
| » Starters: Mike Ryba vs Al Milnar | First | -- |
| Sunday, May 4 |
| » Defeated Senators (6-12), 12-4 | Cleveland Stadium (2-1) | 15-4 | Won 10 |
| » Starters: Walt Masterson vs Al Smith | First | -- |
| Monday, May 5 |
| » Defeated Senators (6-13), 2-1 | League Park II (11-1) | 16-4 | Won 11 |
| » Starters: Ken Chase vs Bob Feller | First | -- |
| Tuesday, May 6 |
| » Lost to Senators (7-13), 5-3 | League Park II (11-2) | 16-5 | |
| » Starters: Dutch Leonard vs Jim Bagby | First | -- |
| Wednesday, May 7 |
| » Lost to Yankees (13-10), 7-5 | League Park II (11-3) | 16-6 | Lost 2 |
| » Starters: Marius Russo vs Al Milnar | First | -- |
| Thursday, May 8 |
| » Lost to Yankees (14-10), 5-4 | League Park II (11-4) | 16-7 | Lost 3 |
| » Starters: Red Ruffing vs Al Smith | First | -- |
| Friday, May 9 |
| » Lost to Browns (6-12), 9-6 | Sportsman's Park III (0-1) | 16-8 | Lost 4 |
| » Starters: Bob Feller vs Vern Kennedy | First | -- |
| Saturday, May 10 |
| » Defeated Browns (6-13), 4-3 | Sportsman's Park III (1-1) | 17-8 | |
| » Starters: Al Milnar vs Bob Harris | First | -- |
| Future Indian Ken Berry is born in Kansas City, MO. |
| Sunday, May 11 |
| » Defeated Browns (6-14), 7-5 | Sportsman's Park III (2-1) | 18-8 | Won 2 |
| » Starters: Jim Bagby vs Elden Auker | First | -- |
| » Lost to Browns (7-14), 6-5 | Sportsman's Park III (2-2) | 18-9 | |
| » Starters: Cal Dorsett vs Johnny Allen | First | -- |
| Monday, May 12 |
| Future Indian Floyd Weaver is born in Ben Franklin, TX. |
| Tuesday, May 13 |
| » Defeated Yankees (14-13), 2-1 | Yankee Stadium (1-0) | 19-9 | |
| » Starters: Bob Feller vs Marius Russo | First | -- |
| Wednesday, May 14 |
| » Defeated Yankees (14-14), 4-1 | Yankee Stadium (2-0) | 20-9 | Won 2 |
| » Starters: Mel Harder vs Red Ruffing | First | -- |
| Thursday, May 15 |
| » Defeated Red Sox (13-10), 6-4 | Fenway Park (1-0) | 21-9 | Won 3 |
| » Starters: Al Milnar vs Earl Johnson | First | -- |
| Friday, May 16 |
| » Defeated Red Sox (13-11), 9-3 | Fenway Park (2-0) | 22-9 | Won 4 |
| » Starters: Jim Bagby vs Mickey Harris | First | -- |
| Saturday, May 17 |
| » Defeated Red Sox (13-12), 12-9 | Fenway Park (3-0) | 23-9 | Won 5 |
| » Starters: Bob Feller vs Charlie Wagner | First | -- |
| Sunday, May 18 |
| » Lost to Athletics (11-18), 10-3 | Shibe Park (0-1) | 23-10 | |
| » Starters: Cal Dorsett vs Johnny Babich | First | -- |
| Monday, May 19 |
| » Lost to Athletics (12-18), 5-4 | Shibe Park (0-2) | 23-11 | Lost 2 |
| » Starters: Al Milnar vs Les McCrabb | First | -- |
| Tuesday, May 20 |
| » Lost to Athletics (13-18), 6-5 | Shibe Park (0-3) | 23-12 | Lost 3 |
| » Starters: Mel Harder vs Bump Hadley | First | -- |
| Wednesday, May 21 |
| » Defeated Senators (14-20), 4-0 | Griffith Stadium (1-0) | 24-12 | |
| » Starters: Bob Feller vs Ken Chase | First | -- |
| Thursday, May 22 |
| » Defeated Senators (14-21), 4-3 | Griffith Stadium (2-0) | 25-12 | Won 2 |
| » Starters: Al Smith vs Sid Hudson | First | -- |
| Friday, May 23 |
| » Defeated Browns (11-21), 4-2 | Cleveland Stadium (3-1) | 26-12 | Won 3 |
| » Starters: Denny Galehouse vs Al Milnar | First | -- |
| Saturday, May 24 |
| » Defeated Browns (11-22), 4-2 | Cleveland Stadium (4-1) | 27-12 | Won 4 |
| » Starters: Elden Auker vs Jim Bagby | First | -- |
| Sunday, May 25 |
| » Defeated Browns (11-23), 6-0 | Cleveland Stadium (5-1) | 28-12 | Won 5 |
| » Starters: Johnny Allen vs Bob Feller | First | -- |
| Monday, May 26 |
| » Lost to Tigers (19-19), 5-3 | League Park II (11-5) | 28-13 | |
| » Starters: Bobo Newsom vs Al Smith | First | -- |
| Tuesday, May 27 |
| » Lost to Tigers (20-19), 9-6 | League Park II (11-6) | 28-14 | Lost 2 |
| » Starters: Schoolboy Rowe vs Al Milnar | First | -- |
| Wednesday, May 28 |
| » Lost to Tigers (21-19), 8-5 | Tiger Stadium (2-2) | 28-15 | Lost 3 |
| » Starters: Mel Harder vs Dizzy Trout | First | -- |
| Thursday, May 29 |
| » Defeated Tigers (21-20), 9-0 | Tiger Stadium (3-2) | 29-15 | |
| » Starters: Bob Feller vs Tommy Bridges | First | -- |
| Friday, May 30 |
| » Lost to White Sox (23-16), 7-1 | Comiskey Park I (1-2) | 29-16 | |
| » Starters: Al Smith vs Ted Lyons | First | -- |
| » Lost to White Sox (24-16), 5-2 | Comiskey Park I (1-3) | 29-17 | Lost 2 |
| » Starters: Jim Bagby vs Thornton Lee | First | -- |
| Sunday, June 1 |
| » Lost to Yankees (24-19), 2-0 | Cleveland Stadium (5-2) | 29-18 | Lost 3 |
| » Starters: Red Ruffing vs Al Milnar | Second | 2½ out |
| » Lost to Yankees (25-19), 5-3 | Cleveland Stadium (5-3) | 29-19 | Lost 4 |
| » Starters: Lefty Gomez vs Mel Harder | Second | 2½ out |
| Future Indian Dean Chance is born in Plain Twsp., OH. |
| Monday, June 2 |
| » Defeated Yankees (25-20), 7-5 | League Park II (12-6) | 30-19 | |
| » Starters: Marius Russo vs Bob Feller | First | -- |
| Thursday, June 5 |
| » Lost to Red Sox (23-19), 14-1 | League Park II (12-7) | 30-20 | |
| » Starters: Mickey Harris vs Al Milnar | First | -- |
| Future Indian Duke Sims is born in Salt Lake City, UT. |
| Friday, June 6 |
| » Defeated Athletics (24-23), 2-0 | League Park II (13-7) | 31-20 | |
| » Starters: Bill Beckmann vs Bob Feller | First | -- |
| Saturday, June 7 |
| » Defeated Athletics (24-24), 6-2 | League Park II (14-7) | 32-20 | Won 2 |
| » Starters: Bump Hadley vs Jim Bagby | First | -- |
| Sunday, June 8 |
| » Defeated Athletics (24-25), 7-4 | Cleveland Stadium (6-3) | 33-20 | Won 3 |
| » Starters: Johnny Babich vs Mel Harder | First | -- |
| » Defeated Athletics (24-26), 8-6 | Cleveland Stadium (7-3) | 34-20 | Won 4 |
| » Starters: Phil Marchildon vs Al Milnar | First | -- |
| Tuesday, June 10 |
| » Defeated Senators (17-35), 4-1 | League Park II (15-7) | 35-20 | Won 5 |
| » Starters: Sid Hudson vs Bob Feller | First | -- |
| Wednesday, June 11 |
| » Defeated Senators (17-36), 6-4 | League Park II (16-7) | 36-20 | Won 6 |
| » Starters: Ken Chase vs Al Smith | First | -- |
| Saturday, June 14 |
| » Lost to Yankees (31-22), 4-1 | Yankee Stadium (2-1) | 36-21 | |
| » Starters: Bob Feller vs Atley Donald | First | -- |
| Sunday, June 15 |
| » Lost to Yankees (32-22), 3-2 | Yankee Stadium (2-2) | 36-22 | Lost 2 |
| » Starters: Jim Bagby vs Red Ruffing | First | -- |
| Monday, June 16 |
| » Lost to Yankees (33-22), 6-4 | Yankee Stadium (2-3) | 36-23 | Lost 3 |
| » Starters: Al Milnar vs Lefty Gomez | First | -- |
| Tuesday, June 17 |
| » Defeated Athletics (26-30), 3-2 | Shibe Park (1-3) | 37-23 | |
| » Starters: Joe Heving vs Phil Marchildon | First | -- |
| Wednesday, June 18 |
| » Defeated Athletics (26-31), 14-2 | Shibe Park (2-3) | 38-23 | Won 2 |
| » Starters: Bob Feller vs Les McCrabb | First | -- |
| Thursday, June 19 |
| » Defeated Athletics (26-32), 12-1 | Shibe Park (3-3) | 39-23 | Won 3 |
| » Starters: Jim Bagby vs Bill Beckmann | First | -- |
| Friday, June 20 |
| » Lost to Senators (21-38), 7-6 | Griffith Stadium (2-1) | 39-24 | |
| » Starters: Al Smith vs Sid Hudson | First | -- |
| Saturday, June 21 |
| » Lost to Senators (22-38), 1-0 | Griffith Stadium (2-2) | 39-25 | Lost 2 |
| » Starters: Al Milnar vs Ken Chase | First | -- |
| Sunday, June 22 |
| » Defeated Senators (22-39), 6-0 | Griffith Stadium (3-2) | 40-25 | |
| » Starters: Bob Feller vs Vern Kennedy | First | -- |
| Tuesday, June 24 |
| » Lost to Red Sox (34-26), 13-2 | Fenway Park (3-1) | 40-26 | |
| » Starters: Mel Harder vs Dick Newsome | First | -- |
| Wednesday, June 25 |
| » Lost to Red Sox (35-26), 7-2 | Fenway Park (3-2) | 40-27 | Lost 2 |
| » Starters: Jim Bagby vs Lefty Grove | Second | 2 out |
| Thursday, June 26 |
| » Defeated Red Sox (35-27), 11-8 | Fenway Park (4-2) | 41-27 | |
| » Starters: Bob Feller vs Mickey Harris | Second | 2 out |
| Friday, June 27 |
| » Defeated White Sox (33-32), 3-1 | Cleveland Stadium (8-3) | 42-27 | Won 2 |
| » Starters: Bill Dietrich vs Al Milnar | First | -- |
| Saturday, June 28 |
| » Lost to White Sox (34-32), 6-4 | Cleveland Stadium (8-4) | 42-28 | |
| » Starters: Thornton Lee vs Al Smith | Second | 2 out |
| Sunday, June 29 |
| » Lost to White Sox (35-32), 9-3 | Cleveland Stadium (8-5) | 42-29 | Lost 2 |
| » Starters: Ted Lyons vs Jim Bagby | Second | 1½ out |
| Monday, June 30 |
| » Lost to Browns (24-41), 12-6 | Sportsman's Park III (2-3) | 42-30 | Lost 3 |
| » Starters: Bob Feller vs Denny Galehouse | Second | 2 out |
| Tuesday, July 1 |
| » Defeated Browns (24-42), 10-6 | Sportsman's Park III (3-3) | 43-30 | |
| » Starters: Al Milnar vs Elden Auker | Second | 2½ out |
| Friday, July 4 |
| » Defeated Browns (24-43), 9-8 | Cleveland Stadium (9-5) | 44-30 | Won 2 |
| » Starters: Johnny Niggeling vs Bob Feller | Second | 2 out |
| » Defeated Browns (24-44), 3-2 | Cleveland Stadium (10-5) | 45-30 | Won 3 |
| » Starters: Bob Harris vs Al Smith | Second | 2 out |
| Saturday, July 5 |
| » Defeated White Sox (37-36), 5-3 | Comiskey Park I (2-3) | 46-30 | Won 4 |
| » Starters: Jim Bagby vs Eddie Smith | Second | 2 out |
| Sunday, July 6 |
| » Lost to White Sox (38-36), 9-4 | Comiskey Park I (2-4) | 46-31 | |
| » Starters: Al Milnar vs Ted Lyons | Second | 3½ out |
| Tuesday, July 8 |
| Future Indian Gary Kroll is born in Culver City, CA. Future Indian Ken Sanders is born in St. Louis, MO. |
| Thursday, July 10 |
| » Defeated Athletics (34-41), 3-2 | Cleveland Stadium (11-5) | 47-31 | |
| » Starters: Chubby Dean vs Bob Feller | Second | 3½ out |
| Saturday, July 12 |
| » Lost to Athletics (35-41), 4-2 | League Park II (16-8) | 47-32 | |
| » Starters: Les McCrabb vs Al Milnar | Second | 5 out |
| Sunday, July 13 |
| » Defeated Red Sox (42-35), 9-6 | Cleveland Stadium (12-5) | 48-32 | |
| » Starters: Charlie Wagner vs Jim Bagby | Second | 5 out |
| » Defeated Red Sox (42-36), 2-1 | Cleveland Stadium (13-5) | 49-32 | Won 2 |
| » Starters: Mickey Harris vs Al Smith | Second | 5 out |
| Monday, July 14 |
| » Defeated Red Sox (42-37), 4-1 | League Park II (17-8) | 50-32 | Won 3 |
| » Starters: Jack Wilson vs Bob Feller | Second | 4 out |
| Tuesday, July 15 |
| » Lost to Red Sox (43-37), 6-2 | League Park II (17-9) | 50-33 | |
| » Starters: Joe Dobson vs Mel Harder | Second | 5 out |
| Wednesday, July 16 |
| » Lost to Yankees (55-27), 10-3 | League Park II (17-10) | 50-34 | Lost 2 |
| » Starters: Atley Donald vs Al Milnar | Second | 6 out |
| Thursday, July 17 |
| » Lost to Yankees (56-27), 4-3 | Cleveland Stadium (13-6) | 50-35 | Lost 3 |
| » Starters: Lefty Gomez vs Al Smith | Second | 7 out |
| Friday, July 18 |
| » Defeated Yankees (56-28), 2-1 | League Park II (18-10) | 51-35 | |
| » Starters: Marius Russo vs Bob Feller | Second | 6 out |
| Saturday, July 19 |
| » Defeated Senators (30-52), 9-8 | League Park II (19-10) | 52-35 | Won 2 |
| » Starters: Ken Chase vs Joe Krakauskas | Second | 6½ out |
| Sunday, July 20 |
| » Lost to Senators (31-52), 8-4 | Cleveland Stadium (13-7) | 52-36 | |
| » Starters: Steve Sundra vs Al Milnar | Second | 7 out |
| » Defeated Senators (31-53), 5-1 | Cleveland Stadium (14-7) | 53-36 | |
| » Starters: Vern Kennedy vs Jim Bagby | Second | 7 out |
| Tuesday, July 22 |
| » Lost to Yankees (60-28), 4-3 | Yankee Stadium (2-4) | 53-37 | |
| » Starters: Bob Feller vs Atley Donald | Second | 8 out |
| Wednesday, July 23 |
| » Lost to Yankees (61-28), 3-2 | Yankee Stadium (2-5) | 53-38 | Lost 2 |
| » Starters: Al Smith vs Marius Russo | Second | 9 out |
| Thursday, July 24 |
| » Lost to Yankees (62-28), 4-1 | Yankee Stadium (2-6) | 53-39 | Lost 3 |
| » Starters: Jim Bagby vs Lefty Gomez | Second | 10 out |
| Friday, July 25 |
| » Lost to Red Sox (48-43), 10-6 | Fenway Park (4-3) | 53-40 | Lost 4 |
| » Starters: Joe Krakauskas vs Lefty Grove | Second | 11 out |
| Saturday, July 26 |
| » Lost to Red Sox (49-43), 4-3 | Fenway Park (4-4) | 53-41 | Lost 5 |
| » Starters: Bob Feller vs Dick Newsome | Second | 12 out |
| Sunday, July 27 |
| » Defeated Red Sox (49-44), 4-0 | Fenway Park (5-4) | 54-41 | |
| » Starters: Joe Heving vs Tex Hughson | Second | 11½ out |
| Tuesday, July 29 |
| » Defeated Senators (36-56), 5-1 | Griffith Stadium (4-2) | 55-41 | Won 2 |
| » Starters: Al Smith vs Ken Chase | Second | 10½ out |
| Wednesday, July 30 |
| » Lost to Senators (37-56), 7-6 | Griffith Stadium (4-3) | 55-42 | |
| » Starters: Bob Feller vs Bill Zuber | Second | 11 out |
| Saturday, August 2 |
| » Defeated Athletics (47-50), 3-2 | Shibe Park (4-3) | 56-42 | |
| » Starters: Jim Bagby vs Johnny Babich | Second | 12½ out |
| Sunday, August 3 |
| » Defeated Athletics (47-51), 6-3 | Shibe Park (5-3) | 57-42 | Won 2 |
| » Starters: Bob Feller vs Les McCrabb | Second | 11½ out |
| » Lost to Athletics (48-51), 4-3 | Shibe Park (5-4) | 57-43 | |
| » Starters: Joe Heving vs Phil Marchildon | Second | 11½ out |
| Tuesday, August 5 |
| » Defeated Tigers (47-56), 2-1 | Cleveland Stadium (15-7) | 58-43 | |
| » Starters: Bobo Newsom vs Al Smith | Second | 11 out |
| Wednesday, August 6 |
| » Lost to Tigers (48-56), 11-2 | League Park II (19-11) | 58-44 | |
| » Starters: Al Benton vs Jim Bagby | Second | 11½ out |
| Thursday, August 7 |
| » Lost to Tigers (49-56), 4-3 | League Park II (19-12) | 58-45 | Lost 2 |
| » Starters: Johnny Gorsica vs Bob Feller | Second | 11½ out |
| Saturday, August 9 |
| » Lost to White Sox (53-53), 7-5 | League Park II (19-13) | 58-46 | Lost 3 |
| » Starters: Eddie Smith vs Joe Krakauskas | Second | 12 out |
| Sunday, August 10 |
| » Lost to White Sox (54-53), 5-2 | Cleveland Stadium (15-8) | 58-47 | Lost 4 |
| » Starters: Ted Lyons vs Al Smith | Second | 14 out |
| » Lost to White Sox (55-53), 2-1 | Cleveland Stadium (15-9) | 58-48 | Lost 5 |
| » Starters: Thornton Lee vs Jim Bagby | Second | 14 out |
| Tuesday, August 12 |
| » Lost to Tigers (51-57), 2-0 | Tiger Stadium (3-3) | 58-49 | Lost 6 |
| » Starters: Bob Feller vs Al Benton | Second | 14 out |
| » Defeated Tigers (51-58), 4-1 | Tiger Stadium (4-3) | 59-49 | |
| » Starters: Al Milnar vs Johnny Gorsica | Second | 14 out |
| » Major-league debuts: Moe Franklin and Hal Manders (Tigers) |
| Wednesday, August 13 |
| » Lost to Browns (44-64), 9-3 | Sportsman's Park III (3-4) | 59-50 | |
| » Starters: Joe Krakauskas vs Denny Galehouse | Second | 14½ out |
| Thursday, August 14 |
| » Tied Browns, 3-3 | Sportsman's Park III (3-4) | 59-50 | |
| » Starters: Chubby Dean vs Johnny Niggeling | Second | 15½ out |
| Friday, August 15 |
| » Lost to White Sox (59-55), 5-2 | Comiskey Park I (2-5) | 59-51 | Lost 2 |
| » Starters: Al Smith vs Buck Ross | Second | 16 out |
| Saturday, August 16 |
| » Lost to White Sox (60-55), 1-0 | Comiskey Park I (2-6) | 59-52 | Lost 3 |
| » Starters: Jim Bagby vs Johnny Rigney | Second | 16 out |
| Sunday, August 17 |
| » Lost to White Sox (61-55), 8-2 | Comiskey Park I (2-7) | 59-53 | Lost 4 |
| » Starters: Bob Feller vs Ted Lyons | Fourth | 18 out |
| » Lost to White Sox (62-55), 4-3 | Comiskey Park I (2-8) | 59-54 | Lost 5 |
| » Starters: Al Milnar vs Eddie Smith | Fourth | 18 out |
| Future Indian Boog Powell is born in Lakeland, FL. |
| Monday, August 18 |
| » Lost to Senators (48-65), 4-2 | Cleveland Stadium (15-10) | 59-55 | Lost 6 |
| » Starters: Steve Sundra vs Steve Gromek | Fourth | 18½ out |
| » Major-league debuts: Steve Gromek (Indians) |
| Tuesday, August 19 |
| » Lost to Senators (49-65), 8-6 | League Park II (19-14) | 59-56 | Lost 7 |
| » Starters: Ken Chase vs Chubby Dean | Fourth | 19 out |
| Future Indian Fred Lasher is born in Poughkeepsie, NY. |
| Wednesday, August 20 |
| » Lost to Senators (50-65), 6-3 | League Park II (19-15) | 59-57 | Lost 8 |
| » Starters: Red Anderson vs Al Smith | Fourth | 19 out |
| Thursday, August 21 |
| » Defeated Yankees (81-42), 2-0 | League Park II (20-15) | 60-57 | |
| » Starters: Atley Donald vs Bob Feller | Fourth | 18 out |
| Friday, August 22 |
| » Defeated Yankees (81-43), 5-4 | League Park II (21-15) | 61-57 | Won 2 |
| » Starters: Marv Breuer vs Jim Bagby | Fourth | 17 out |
| Saturday, August 23 |
| » Lost to Yankees (82-43), 7-2 | League Park II (21-16) | 61-58 | |
| » Starters: Lefty Gomez vs Chubby Dean | Fourth | 18 out |
| Sunday, August 24 |
| » Defeated Red Sox (63-60), 4-3 | Cleveland Stadium (16-10) | 62-58 | |
| » Starters: Mickey Harris vs Al Milnar | Third | 18 out |
| » Defeated Red Sox (63-61), 5-2 | Cleveland Stadium (17-10) | 63-58 | Won 2 |
| » Starters: Earl Johnson vs Al Smith | Third | 18 out |
| Monday, August 25 |
| » Lost to Red Sox (64-61), 1-0 | Cleveland Stadium (17-11) | 63-59 | |
| » Starters: Charlie Wagner vs Bob Feller | Third | 18 out |
| Tuesday, August 26 |
| » Lost to Red Sox (65-61), 9-4 | League Park II (21-17) | 63-60 | Lost 2 |
| » Starters: Dick Newsome vs Jim Bagby | Fourth | 18½ out |
| Wednesday, August 27 |
| » Defeated Athletics (55-70), 11-4 | League Park II (22-17) | 64-60 | |
| » Starters: Tom Ferrick vs Steve Gromek | Third | 18½ out |
| Thursday, August 28 |
| » Lost to Athletics (56-70), 5-3 | League Park II (22-18) | 64-61 | |
| » Starters: Johnny Babich vs Al Milnar | Third | 19½ out |
| Saturday, August 30 |
| » Lost to Tigers (61-68), 7-3 | League Park II (22-19) | 64-62 | Lost 2 |
| » Starters: Bobo Newsom vs Al Smith | Fourth | 20½ out |
| Sunday, August 31 |
| » Lost to Tigers (62-68), 7-5 | Cleveland Stadium (17-12) | 64-63 | Lost 3 |
| » Starters: Schoolboy Rowe vs Bob Feller | Fourth | 21 out |
| » Defeated Tigers (62-69), 7-4 | Cleveland Stadium (18-12) | 65-63 | |
| » Starters: Tommy Bridges vs Chubby Dean | Fourth | 21 out |
| Monday, September 1 |
| » Lost to White Sox (69-64), 7-5 | Cleveland Stadium (18-13) | 65-64 | |
| » Starters: Thornton Lee vs Jim Bagby | Fourth | 22 out |
| » Lost to White Sox (70-64), 4-3 | Cleveland Stadium (18-14) | 65-65 | Lost 2 |
| » Starters: Johnny Rigney vs Al Milnar | Fourth | 22 out |
| Thursday, September 4 |
| » Defeated Tigers (64-70), 7-6 | Tiger Stadium (5-3) | 66-65 | |
| » Starters: Bob Feller vs Hal Newhouser | Fourth | 22½ out |
| Future Indian Ken Harrelson is born in Woodruff, SC. |
| Saturday, September 6 |
| » Lost to Tigers (65-70), 6-2 | Tiger Stadium (5-4) | 66-66 | |
| » Starters: Al Smith vs Bobo Newsom | Fourth | 23 out |
| » Lost to Tigers (66-70), 7-2 | Tiger Stadium (5-5) | 66-67 | Lost 2 |
| » Starters: Al Milnar vs Al Benton | Fourth | 23 out |
| Sunday, September 7 |
| » Lost to Tigers (67-70), 4-1 | Tiger Stadium (5-6) | 66-68 | Lost 3 |
| » Starters: Chubby Dean vs Tommy Bridges | Fourth | 24 out |
| Monday, September 8 |
| Former Indian Joe Boehling dies in Richmond, VA at the age of 51. |
| Tuesday, September 9 |
| » Defeated Athletics (59-78), 13-7 | Shibe Park (6-4) | 67-68 | |
| » Starters: Bob Feller vs Les McCrabb | Fourth | 24 out |
| » Major-league debuts: Jim Hegan and Bob Lemon (Indians) |
| Wednesday, September 10 |
| » Lost to Athletics (60-78), 6-4 | Shibe Park (6-5) | 67-69 | |
| » Starters: Red Embree vs Fred Caligiuri | Fourth | 24½ out |
| » Major-league debuts: Hank Edwards and Red Embree (Indians) |
| Thursday, September 11 |
| » Defeated Senators (59-77), 8-5 | Griffith Stadium (5-3) | 68-69 | |
| » Starters: Al Smith vs Dutch Leonard | Fourth | 23 out |
| » Defeated Senators (59-78), 3-2 | Griffith Stadium (6-3) | 69-69 | Won 2 |
| » Starters: Al Milnar vs Ken Chase | Fourth | 23 out |
| Friday, September 12 |
| » Lost to Senators (60-78), 7-4 | Griffith Stadium (6-4) | 69-70 | |
| » Starters: Jim Bagby vs Early Wynn | Fourth | 24 out |
| Saturday, September 13 |
| » Lost to Senators (61-78), 6-5 | Griffith Stadium (6-5) | 69-71 | Lost 2 |
| » Starters: Chubby Dean vs Red Anderson | Fourth | 24 out |
| Sunday, September 14 |
| » Lost to Yankees (95-48), 6-3 | Yankee Stadium (2-7) | 69-72 | Lost 3 |
| » Starters: Bob Feller vs Red Ruffing | Fourth | 24 out |
| » Defeated Yankees (95-49), 5-2 | Yankee Stadium (3-7) | 70-72 | |
| » Starters: Joe Krakauskas vs Marv Breuer | Fourth | 24 out |
| Monday, September 15 |
| » Lost to Yankees (96-49), 4-2 | Yankee Stadium (3-8) | 70-73 | |
| » Starters: Al Smith vs Lefty Gomez | Fourth | 25 out |
| Tuesday, September 16 |
| » Major-league debuts: Hillis Layne (Senators) Hoot Evers (Tigers) |
| Wednesday, September 17 |
| » Lost to Red Sox (78-67), 3-2 | Fenway Park (5-5) | 70-74 | Lost 2 |
| » Starters: Jim Bagby vs Joe Dobson | Fourth | 26 out |
| Thursday, September 18 |
| » Defeated Red Sox (78-68), 6-1 | Fenway Park (6-5) | 71-74 | |
| » Starters: Bob Feller vs Dick Newsome | Fourth | 25½ out |
| Saturday, September 20 |
| » Defeated Browns (65-80), 6-2 | League Park II (23-19) | 72-74 | Won 2 |
| » Starters: Bob Harris vs Al Milnar | Fourth | 25½ out |
| Sunday, September 21 |
| » Defeated Browns (65-81), 14-0 | League Park II (24-19) | 73-74 | Won 3 |
| » Starters: Elden Auker vs Al Smith | Fourth | 25 out |
| » Lost to Browns (66-81), 3-0 | League Park II (24-20) | 73-75 | |
| » Starters: Denny Galehouse vs Chubby Dean | Fourth | 25 out |
| Monday, September 22 |
| » Lost to Browns (67-81), 5-0 | League Park II (24-21) | 73-76 | Lost 2 |
| » Starters: Johnny Niggeling vs Bob Feller | Fourth | 25½ out |
| Wednesday, September 24 |
| » Lost to White Sox (75-76), 2-1 | Comiskey Park I (2-9) | 73-77 | Lost 3 |
| » Starters: Jim Bagby vs Thornton Lee | Fifth | 26 out |
| Friday, September 26 |
| » Lost to Browns (69-82), 6-5 | Sportsman's Park III (3-5) | 73-78 | Lost 4 |
| » Starters: Al Milnar vs Elden Auker | Fourth | 27 out |
| » Defeated Browns (69-83), 3-2 | Sportsman's Park III (4-5) | 74-78 | |
| » Starters: Bob Feller vs Denny Galehouse | Fourth | 27 out |
| Saturday, September 27 |
| » Defeated Browns (69-84), 4-3 | Sportsman's Park III (5-5) | 75-78 | Won 2 |
| » Starters: Al Smith vs Johnny Niggeling | Fourth | 26 out |
| Sunday, September 28 |
| » Lost to Browns (70-84), 5-4 | Sportsman's Park III (5-6) | 75-79 | |
| » Starters: Chubby Dean vs Bob Muncrief | Fourth | 26 out |
| Wednesday, October 29 |
| Former Indian Harvey Hendrick dies in Covington, TN at the age of 44. |
| Friday, November 14 |
| Future Indian Darrell Sutherland is born in Glendale, CA. |
| Tuesday, December 16 |
| Future Indian Adolfo Phillips is born in Bethania, Panama. |
Game information provided by Retrosheet (www.retrosheet.org) |
