| Friday, February 21 |
| Former Cub Frank Corridon dies in Syracuse, NY at the age of 61. |
| Monday, March 3 |
| Former Cub Doc Parker dies in Chicago, IL at the age of 69. |
| Sunday, April 13 |
| Future Cub John Stephenson is born in South Portsmouth, KY. Former Cub Joe Schultz, Sr. dies in Columbia, SC at the age of 48. |
| Monday, April 14 |
| » Major-league debuts: Phil Rizzuto and Johnny Sturm (Yankees) |
| Tuesday, April 15 |
| » Defeated Pirates (0-1), 7-4 | Wrigley Field (1-0) | 1-0 | |
| » Starters: Bob Klinger vs Claude Passeau | First | -- |
| » Major-league debuts: Lou Novikoff, Lou Stringer and Eddie Waitkus (Cubs) |
| Thursday, April 17 |
| » Lost to Pirates (1-1), 7-2 | Wrigley Field (1-1) | 1-1 | |
| » Starters: Rip Sewell vs Vern Olsen | Third | 1½ out |
| Friday, April 18 |
| » Defeated Cardinals (3-1), 6-4 | Sportsman's Park III (1-0) | 2-1 | |
| » Starters: Charlie Root vs Clyde Shoun | Third | 1½ out |
| Saturday, April 19 |
| » Major-league debuts: Tommy Hughes (Phillies) |
| Sunday, April 20 |
| » Defeated Cardinals (3-2), 11-10 | Sportsman's Park III (2-0) | 3-1 | Won 2 |
| » Starters: Claude Passeau vs Max Lanier | Second | 1 out |
| Tuesday, April 22 |
| » Lost to Reds (3-4), 1-0 | Wrigley Field (1-2) | 3-2 | |
| » Starters: Johnny Vander Meer vs Bill Lee | Third | 1½ out |
| Wednesday, April 23 |
| » Lost to Reds (4-4), 5-0 | Wrigley Field (1-3) | 3-3 | Lost 2 |
| » Starters: Bucky Walters vs Paul Erickson | Fourth | 2½ out |
| Thursday, April 24 |
| » Lost to Pirates (3-5), 2-1 | Forbes Field (0-1) | 3-4 | Lost 3 |
| » Starters: Larry French vs Bob Klinger | Fifth | 3 out |
| Friday, April 25 |
| » Defeated Pirates (3-6), 8-7 | Forbes Field (1-1) | 4-4 | |
| » Starters: Dizzy Dean vs Joe Bowman | Fourth | 3 out |
| Saturday, April 26 |
| » Lost to Cardinals (7-3), 6-2 | Wrigley Field (1-4) | 4-5 | |
| » Starters: Max Lanier vs Charlie Root | Fifth | 3 out |
| Sunday, April 27 |
| » Lost to Cardinals (8-3), 8-5 | Wrigley Field (1-5) | 4-6 | Lost 2 |
| » Starters: Mort Cooper vs Bill Lee | Fifth | 3½ out |
| » Major-league debuts: Bob Scheffing (Cubs) |
| Tuesday, April 29 |
| » Lost to Braves (6-8), 6-3 | Braves Field (0-1) | 4-7 | Lost 3 |
| » Starters: Claude Passeau vs Frank LaManna | Sixth | 5½ out |
| Wednesday, April 30 |
| » Defeated Braves (6-9), 9-4 | Braves Field (1-1) | 5-7 | |
| » Starters: Larry French vs Manny Salvo | Fifth | 4½ out |
| Friday, May 2 |
| » Lost to Dodgers (14-5), 7-3 | Ebbets Field (0-1) | 5-8 | |
| » Starters: Bill Lee vs Whit Wyatt | Sixth | 6 out |
| Saturday, May 3 |
| » Lost to Dodgers (15-5), 4-3 | Ebbets Field (0-2) | 5-9 | Lost 2 |
| » Starters: Charlie Root vs Kirby Higbe | Sixth | 7 out |
| Sunday, May 4 |
| » Lost to Giants (9-8), 9-4 | Polo Grounds V (0-1) | 5-10 | Lost 3 |
| » Starters: Larry French vs Cliff Melton | Seventh | 8 out |
| Tuesday, May 6 |
| » Lost to Giants (10-8), 5-3 | Polo Grounds V (0-2) | 5-11 | Lost 4 |
| » Starters: Claude Passeau vs Carl Hubbell | Seventh | 8½ out |
| Wednesday, May 7 |
| » Defeated Phillies (7-14), 11-2 | Shibe Park (1-0) | 6-11 | |
| » Starters: Bill Lee vs Bill Crouch | Fifth | 7½ out |
| Thursday, May 8 |
| » Defeated Phillies (7-15), 5-1 | Shibe Park (2-0) | 7-11 | Won 2 |
| » Starters: Vern Olsen vs Ike Pearson | Fifth | 8 out |
| Saturday, May 10 |
| » Lost to Reds (10-11), 5-1 | Crosley Field (0-1) | 7-12 | |
| » Starters: Larry French vs Paul Derringer | Sixth | 9 out |
| Sunday, May 11 |
| » Defeated Reds (10-12), 9-1 | Crosley Field (1-1) | 8-12 | |
| » Starters: Claude Passeau vs Johnny Vander Meer | Sixth | 9 out |
| Monday, May 12 |
| » Defeated Reds (10-13), 12-1 | Crosley Field (2-1) | 9-12 | Won 2 |
| » Starters: Bill Lee vs Monte Pearson | Fifth | 8½ out |
| Tuesday, May 13 |
| » Defeated Braves (10-14), 4-3 | Wrigley Field (2-5) | 10-12 | Won 3 |
| » Starters: Jim Tobin vs Vern Olsen | Fourth | 8½ out |
| Thursday, May 15 |
| » Lost to Giants (13-11), 2-1 | Wrigley Field (2-6) | 10-13 | |
| » Starters: Hal Schumacher vs Claude Passeau | Fifth | 9½ out |
| Friday, May 16 |
| » Lost to Giants (14-11), 4-2 | Wrigley Field (2-7) | 10-14 | Lost 2 |
| » Starters: Bill Lohrman vs Bill Lee | Fifth | 9½ out |
| Saturday, May 17 |
| » Lost to Giants (15-11), 9-0 | Wrigley Field (2-8) | 10-15 | Lost 3 |
| » Starters: Cliff Melton vs Vern Olsen | Fifth | 10 out |
| Sunday, May 18 |
| » Defeated Dodgers (22-8), 7-4 | Wrigley Field (3-8) | 11-15 | |
| » Starters: Whit Wyatt vs Larry French | Fifth | 9 out |
| Monday, May 19 |
| » Defeated Dodgers (22-9), 14-1 | Wrigley Field (4-8) | 12-15 | Won 2 |
| » Starters: Hugh Casey vs Claude Passeau | Fourth | 7½ out |
| Tuesday, May 20 |
| » Defeated Dodgers (22-10), 9-1 | Wrigley Field (5-8) | 13-15 | Won 3 |
| » Starters: Kirby Higbe vs Bill Lee | Fourth | 6½ out |
| Wednesday, May 21 |
| » Defeated Phillies (10-21), 7-3 | Wrigley Field (6-8) | 14-15 | Won 4 |
| » Starters: Lefty Hoerst vs Paul Erickson | Fourth | 6½ out |
| Friday, May 23 |
| » Lost to Reds (15-18), 8-4 | Wrigley Field (6-9) | 14-16 | |
| » Starters: Johnny Vander Meer vs Claude Passeau | Fourth | 8 out |
| Saturday, May 24 |
| » Defeated Reds (15-19), 4-2 | Wrigley Field (7-9) | 15-16 | |
| » Starters: Jim Turner vs Bill Lee | Fourth | 8½ out |
| » Lost to Reds (16-19), 4-1 | Wrigley Field (7-10) | 15-17 | |
| » Starters: Whitey Moore vs Larry French | Fourth | 8½ out |
| Sunday, May 25 |
| » Defeated Reds (16-20), 3-2 | Wrigley Field (8-10) | 16-17 | |
| » Starters: Paul Derringer vs Charlie Root | Fourth | 9 out |
| Monday, May 26 |
| » Lost to Cardinals (27-9), 12-11 | Sportsman's Park III (2-1) | 16-18 | |
| » Starters: Vern Olsen vs Clyde Shoun | Fourth | 10 out |
| Tuesday, May 27 |
| » Lost to Cardinals (28-9), 3-2 | Sportsman's Park III (2-2) | 16-19 | Lost 2 |
| » Starters: Jake Mooty vs Max Lanier | Fifth | 11 out |
| Wednesday, May 28 |
| » Lost to Cardinals (29-9), 6-5 | Sportsman's Park III (2-3) | 16-20 | Lost 3 |
| » Starters: Larry French vs Ernie White | Fifth | 12 out |
| Friday, May 30 |
| » Defeated Pirates (13-21), 7-6 | Forbes Field (2-1) | 17-20 | |
| » Starters: Bill Lee vs Rip Sewell | Fourth | 12½ out |
| » Lost to Pirates (14-21), 5-4 | Forbes Field (2-2) | 17-21 | |
| » Starters: Claude Passeau vs Lefty Wilkie | Fourth | 12½ out |
| Sunday, June 1 |
| » Defeated Phillies (12-28), 9-5 | Shibe Park (3-0) | 18-21 | |
| » Starters: Charlie Root vs Ike Pearson | Third | 10½ out |
| » Defeated Phillies (12-29), 1-0 | Shibe Park (4-0) | 19-21 | Won 2 |
| » Starters: Jake Mooty vs Lee Grissom | Third | 10½ out |
| Monday, June 2 |
| » Lost to Phillies (13-29), 3-2 | Shibe Park (4-1) | 19-22 | |
| » Starters: Larry French vs Johnny Podgajny | Fifth | 11½ out |
| Tuesday, June 3 |
| » Lost to Phillies (14-29), 7-0 | Shibe Park (4-2) | 19-23 | Lost 2 |
| » Starters: Bill Lee vs Tommy Hughes | Fourth | 11½ out |
| Friday, June 6 |
| » Lost to Dodgers (33-13), 4-1 | Ebbets Field (0-3) | 19-24 | Lost 3 |
| » Starters: Jake Mooty vs Kirby Higbe | Fifth | 12½ out |
| Saturday, June 7 |
| » Defeated Braves (15-27), 5-1 | Braves Field (2-1) | 20-24 | |
| » Starters: Claude Passeau vs Dick Errickson | Fifth | 12 out |
| Sunday, June 8 |
| » Defeated Braves (15-28), 5-1 | Braves Field (3-1) | 21-24 | Won 2 |
| » Starters: Bill Lee vs Art Johnson | Fifth | 11 out |
| » Lost to Braves (16-28), 13-1 | Braves Field (3-2) | 21-25 | |
| » Starters: Larry French vs Al Javery | Fifth | 11 out |
| Monday, June 9 |
| » Defeated Braves (16-29), 13-6 | Braves Field (4-2) | 22-25 | |
| » Starters: Charlie Root vs Tom Earley | Fifth | 11 out |
| Tuesday, June 10 |
| » Defeated Giants (24-24), 11-0 | Polo Grounds V (1-2) | 23-25 | Won 2 |
| » Starters: Vern Olsen vs Bill McGee | Fifth | 11 out |
| Wednesday, June 11 |
| » Defeated Giants (24-25), 3-2 | Polo Grounds V (2-2) | 24-25 | Won 3 |
| » Starters: Claude Passeau vs Cliff Melton | Fifth | 11½ out |
| » Lost to Giants (25-25), 8-7 | Polo Grounds V (2-3) | 24-26 | |
| » Starters: Jake Mooty vs Bill Lohrman | Fifth | 11½ out |
| Thursday, June 12 |
| » Lost to Giants (26-25), 2-0 | Polo Grounds V (2-4) | 24-27 | Lost 2 |
| » Starters: Bill Lee vs Carl Hubbell | Fifth | 12 out |
| Future Cub Jerry Arrigo is born in Chicago, IL. |
| Saturday, June 14 |
| » Defeated Phillies (16-35), 3-0 | Wrigley Field (9-10) | 25-27 | |
| » Starters: Cy Blanton vs Vern Olsen | Fifth | 11½ out |
| Sunday, June 15 |
| » Defeated Phillies (16-36), 6-0 | Wrigley Field (10-10) | 26-27 | Won 2 |
| » Starters: Tommy Hughes vs Claude Passeau | Fifth | 11½ out |
| » Lost to Phillies (17-36), 8-4 | Wrigley Field (10-11) | 26-28 | |
| » Starters: Johnny Podgajny vs Charlie Root | Fifth | 11½ out |
| Monday, June 16 |
| » Defeated Phillies (17-37), 3-1 | Wrigley Field (11-11) | 27-28 | |
| » Starters: Lee Grissom vs Jake Mooty | Fifth | 11 out |
| Tuesday, June 17 |
| » Lost to Dodgers (37-19), 7-6 | Wrigley Field (11-12) | 27-29 | |
| » Starters: Whit Wyatt vs Bill Lee | Fifth | 12 out |
| Wednesday, June 18 |
| » Defeated Dodgers (37-20), 5-1 | Wrigley Field (12-12) | 28-29 | |
| » Starters: Luke Hamlin vs Vern Olsen | Fifth | 12 out |
| Thursday, June 19 |
| » Lost to Dodgers (38-20), 9-4 | Wrigley Field (12-13) | 28-30 | |
| » Starters: Kirby Higbe vs Claude Passeau | Fifth | 13 out |
| Friday, June 20 |
| » Defeated Braves (19-34), 5-0 | Wrigley Field (13-13) | 29-30 | |
| » Starters: Dick Errickson vs Larry French | Fifth | 12 out |
| Saturday, June 21 |
| » Lost to Braves (20-34), 4-3 | Wrigley Field (13-14) | 29-31 | |
| » Starters: Art Johnson vs Bill Lee | Fifth | 13 out |
| Sunday, June 22 |
| » Lost to Braves (21-34), 6-5 | Wrigley Field (13-15) | 29-32 | Lost 2 |
| » Starters: Bill Posedel vs Vern Olsen | Fifth | 13 out |
| » Lost to Braves (22-34), 3-2 | Wrigley Field (13-16) | 29-33 | Lost 3 |
| » Starters: Al Javery vs Jake Mooty | Fifth | 13 out |
| Monday, June 23 |
| » Defeated Giants (32-29), 1-0 | Wrigley Field (14-16) | 30-33 | |
| » Starters: Hal Schumacher vs Claude Passeau | Fifth | 12½ out |
| Tuesday, June 24 |
| » Lost to Giants (33-29), 3-1 | Wrigley Field (14-17) | 30-34 | |
| » Starters: Cliff Melton vs Larry French | Fifth | 13½ out |
| Wednesday, June 25 |
| » Lost to Giants (34-29), 4-1 | Wrigley Field (14-18) | 30-35 | Lost 2 |
| » Starters: Bob Carpenter vs Bill Lee | Fifth | 14½ out |
| Friday, June 27 |
| » Lost to Pirates (25-32), 4-2 | Wrigley Field (14-19) | 30-36 | Lost 3 |
| » Starters: Rip Sewell vs Claude Passeau | Fifth | 15½ out |
| Saturday, June 28 |
| » Defeated Pirates (25-33), 3-2 | Wrigley Field (15-19) | 31-36 | |
| » Starters: Max Butcher vs Vern Olsen | Fifth | 15 out |
| Sunday, June 29 |
| » Lost to Pirates (26-33), 8-2 | Wrigley Field (15-20) | 31-37 | |
| » Starters: Johnny Lanning vs Larry French | Sixth | 16 out |
| » Lost to Pirates (27-33), 3-2 | Wrigley Field (15-21) | 31-38 | Lost 2 |
| » Starters: Joe Bowman vs Bill Lee | Sixth | 16 out |
| » Major-league debuts: Paul Erickson (Cubs) |
| Future Cub John Boccabella is born in San Francisco, CA. |
| Monday, June 30 |
| » Lost to Reds (36-33), 7-1 | Crosley Field (2-2) | 31-39 | Lost 3 |
| » Starters: Charlie Root vs Elmer Riddle | Fifth | 16 out |
| Thursday, July 3 |
| » Defeated Cardinals (48-24), 2-1 | Wrigley Field (16-21) | 32-39 | |
| » Starters: Max Lanier vs Claude Passeau | Fifth | 15½ out |
| Friday, July 4 |
| » Defeated Cardinals (48-25), 6-5 | Wrigley Field (17-21) | 33-39 | Won 2 |
| » Starters: Ernie White vs Vern Olsen | Fifth | 14½ out |
| » Defeated Cardinals (48-26), 5-2 | Wrigley Field (18-21) | 34-39 | Won 3 |
| » Starters: Clyde Shoun vs Larry French | Fifth | 14½ out |
| Saturday, July 5 |
| » Lost to Pirates (31-35), 9-6 | Forbes Field (2-3) | 34-40 | |
| » Starters: Bill Lee vs Joe Sullivan | Sixth | 15½ out |
| Sunday, July 6 |
| » Lost to Pirates (32-35), 2-1 | Forbes Field (2-4) | 34-41 | Lost 2 |
| » Starters: Claude Passeau vs Rip Sewell | Sixth | 17 out |
| » Lost to Pirates (33-35), 13-4 | Forbes Field (2-5) | 34-42 | Lost 3 |
| » Starters: Charlie Root vs Max Butcher | Sixth | 17 out |
| Thursday, July 10 |
| » Defeated Braves (29-43), 3-1 | Braves Field (5-2) | 35-42 | |
| » Starters: Vern Olsen vs Al Javery | Sixth | 17 out |
| Friday, July 11 |
| » Lost to Braves (30-43), 7-2 | Braves Field (5-3) | 35-43 | |
| » Starters: Larry French vs Jim Tobin | Sixth | 18 out |
| Sunday, July 13 |
| » Defeated Dodgers (52-26), 10-3 | Ebbets Field (1-3) | 36-43 | |
| » Starters: Claude Passeau vs Hugh Casey | Sixth | 17½ out |
| » Lost to Dodgers (53-26), 3-1 | Ebbets Field (1-4) | 36-44 | |
| » Starters: Bill Lee vs Newt Kimball | Sixth | 17½ out |
| Monday, July 14 |
| » Lost to Dodgers (54-26), 1-0 | Ebbets Field (1-5) | 36-45 | Lost 2 |
| » Starters: Vern Olsen vs Kirby Higbe | Sixth | 18½ out |
| Tuesday, July 15 |
| » Lost to Dodgers (55-26), 7-0 | Ebbets Field (1-6) | 36-46 | Lost 3 |
| » Starters: Larry French vs Curt Davis | Sixth | 20½ out |
| » Lost to Dodgers (56-26), 8-4 | Ebbets Field (1-7) | 36-47 | Lost 4 |
| » Starters: Paul Erickson vs Luke Hamlin | Sixth | 20½ out |
| Former Cub Clarence Currie dies in Little Chute, WI at the age of 63. Former Cub Frank Isbell dies in Wichita, KS at the age of 66. |
| Wednesday, July 16 |
| » Defeated Phillies (21-60), 9-5 | Shibe Park (5-2) | 37-47 | |
| » Starters: Charlie Root vs Tommy Hughes | Sixth | 19½ out |
| Thursday, July 17 |
| » Tied Phillies, 2-2 | Shibe Park (5-2) | 37-47 | |
| » Starters: Vance Page vs Johnny Podgajny | Sixth | 19½ out |
| Sunday, July 20 |
| » Lost to Giants (44-36), 7-5 | Polo Grounds V (2-5) | 37-48 | |
| » Starters: Claude Passeau vs Carl Hubbell | Sixth | 19 out |
| » Defeated Giants (44-37), 7-4 | Polo Grounds V (3-5) | 38-48 | |
| » Starters: Vern Olsen vs Hal Schumacher | Sixth | 19 out |
| Monday, July 21 |
| Future Cub Nelson Mathews is born in Columbia, IL. |
| Tuesday, July 22 |
| » Defeated Braves (34-51), 13-2 | Wrigley Field (19-21) | 39-48 | Won 2 |
| » Starters: Bill Posedel vs Bill Lee | Fifth | 17½ out |
| Wednesday, July 23 |
| » Lost to Braves (35-51), 6-1 | Wrigley Field (19-22) | 39-49 | |
| » Starters: Dick Errickson vs Vance Page | Fifth | 18½ out |
| Thursday, July 24 |
| » Defeated Braves (35-52), 5-4 | Wrigley Field (20-22) | 40-49 | |
| » Starters: Al Javery vs Claude Passeau | Fifth | 18½ out |
| Friday, July 25 |
| » Lost to Giants (45-40), 5-2 | Wrigley Field (20-23) | 40-50 | |
| » Starters: Bill Lohrman vs Vern Olsen | Sixth | 18½ out |
| Saturday, July 26 |
| » Defeated Giants (45-41), 5-3 | Wrigley Field (21-23) | 41-50 | |
| » Starters: Carl Hubbell vs Claude Passeau | Sixth | 18½ out |
| Sunday, July 27 |
| » Defeated Giants (45-42), 9-2 | Wrigley Field (22-23) | 42-50 | Won 2 |
| » Starters: Cliff Melton vs Vern Olsen | Sixth | 18 out |
| Tuesday, July 29 |
| » Defeated Phillies (23-68), 12-4 | Wrigley Field (23-23) | 43-50 | Won 3 |
| » Starters: Ike Pearson vs Bill Lee | Sixth | 17½ out |
| Wednesday, July 30 |
| » Lost to Phillies (24-68), 8-4 | Wrigley Field (23-24) | 43-51 | |
| » Starters: Cy Blanton vs Jake Mooty | Sixth | 18 out |
| » Defeated Phillies (24-69), 5-3 | Wrigley Field (24-24) | 44-51 | |
| » Starters: Tommy Hughes vs Vance Page | Sixth | 18 out |
| Thursday, July 31 |
| » Lost to Phillies (25-69), 7-2 | Wrigley Field (24-25) | 44-52 | |
| » Starters: Johnny Podgajny vs Charlie Root | Sixth | 18 out |
| Friday, August 1 |
| » Lost to Dodgers (61-36), 5-4 | Wrigley Field (24-26) | 44-53 | Lost 2 |
| » Starters: Johnny Allen vs Vern Olsen | Sixth | 18 out |
| Saturday, August 2 |
| » Lost to Dodgers (62-36), 9-6 | Wrigley Field (24-27) | 44-54 | Lost 3 |
| » Starters: Kirby Higbe vs Larry French | Sixth | 19 out |
| Sunday, August 3 |
| » Lost to Dodgers (63-36), 10-2 | Wrigley Field (24-28) | 44-55 | Lost 4 |
| » Starters: Whit Wyatt vs Bill Lee | Sixth | 20½ out |
| Monday, August 4 |
| » Lost to Cardinals (66-35), 4-2 | Wrigley Field (24-29) | 44-56 | Lost 5 |
| » Starters: Ernie White vs Paul Erickson | Sixth | 21½ out |
| Tuesday, August 5 |
| » Defeated Cardinals (66-36), 6-2 | Wrigley Field (25-29) | 45-56 | |
| » Starters: Max Lanier vs Vern Olsen | Sixth | 20½ out |
| Wednesday, August 6 |
| » Lost to Pirates (56-43), 13-3 | Wrigley Field (25-30) | 45-57 | |
| » Starters: Rip Sewell vs Tot Pressnell | Sixth | 20½ out |
| Future Cub Ray Culp is born in Elgin, TX. |
| Thursday, August 7 |
| » Lost to Pirates (57-43), 4-3 | Wrigley Field (25-31) | 45-58 | Lost 2 |
| » Starters: Ken Heintzelman vs Jake Mooty | Sixth | 21½ out |
| Friday, August 8 |
| » Defeated Pirates (57-44), 1-0 | Wrigley Field (26-31) | 46-58 | |
| » Starters: Johnny Lanning vs Paul Erickson | Sixth | 21 out |
| Saturday, August 9 |
| » Lost to Reds (55-48), 7-2 | Wrigley Field (26-32) | 46-59 | |
| » Starters: Elmer Riddle vs Vern Olsen | Sixth | 21 out |
| Sunday, August 10 |
| » Lost to Reds (56-48), 3-1 | Wrigley Field (26-33) | 46-60 | Lost 2 |
| » Starters: Johnny Vander Meer vs Charlie Root | Sixth | 22½ out |
| Monday, August 11 |
| » Lost to Cardinals (70-38), 7-5 | Sportsman's Park III (2-4) | 46-61 | Lost 3 |
| » Starters: Larry French vs Lon Warneke | Sixth | 23½ out |
| Tuesday, August 12 |
| » Lost to Cardinals (71-38), 8-7 | Sportsman's Park III (2-5) | 46-62 | Lost 4 |
| » Starters: Vern Olsen vs Max Lanier | Sixth | 24½ out |
| Wednesday, August 13 |
| » Defeated Pirates (58-47), 6-4 | Forbes Field (3-5) | 47-62 | |
| » Starters: Paul Erickson vs Johnny Lanning | Sixth | 23½ out |
| Thursday, August 14 |
| » Defeated Pirates (58-48), 6-2 | Forbes Field (4-5) | 48-62 | Won 2 |
| » Starters: Claude Passeau vs Max Butcher | Sixth | 23 out |
| Friday, August 15 |
| » Lost to Reds (58-48), 3-1 | Crosley Field (2-3) | 48-63 | |
| » Starters: Vallie Eaves vs Johnny Vander Meer | Fifth | 23½ out |
| Saturday, August 16 |
| » Lost to Reds (59-48), 4-1 | Crosley Field (2-4) | 48-64 | Lost 2 |
| » Starters: Vern Olsen vs Elmer Riddle | Fifth | 23½ out |
| Sunday, August 17 |
| » Lost to Reds (60-48), 6-3 | Crosley Field (2-5) | 48-65 | Lost 3 |
| » Starters: Paul Erickson vs Bucky Walters | Fifth | 24 out |
| » Defeated Reds (60-49), 4-2 | Crosley Field (3-5) | 49-65 | |
| » Starters: Charlie Root vs Jim Turner | Fifth | 24 out |
| Monday, August 18 |
| » Lost to Giants (55-55), 6-4 | Polo Grounds V (3-6) | 49-66 | |
| » Starters: Claude Passeau vs Hal Schumacher | Sixth | 25½ out |
| » Lost to Giants (56-55), 7-1 | Polo Grounds V (3-7) | 49-67 | Lost 2 |
| » Starters: Larry French vs Cliff Melton | Sixth | 25½ out |
| Wednesday, August 20 |
| » Defeated Giants (56-56), 9-4 | Polo Grounds V (4-7) | 50-67 | |
| » Starters: Vallie Eaves vs Carl Hubbell | Sixth | 26½ out |
| Thursday, August 21 |
| » Defeated Dodgers (76-41), 6-2 | Ebbets Field (2-7) | 51-67 | Won 2 |
| » Starters: Jake Mooty vs Luke Hamlin | Sixth | 25½ out |
| Friday, August 22 |
| » Lost to Dodgers (77-41), 8-5 | Ebbets Field (2-8) | 51-68 | |
| » Starters: Paul Erickson vs Newt Kimball | Sixth | 26½ out |
| Saturday, August 23 |
| » Defeated Dodgers (77-42), 7-1 | Ebbets Field (3-8) | 52-68 | |
| » Starters: Claude Passeau vs Tom Drake | Sixth | 25½ out |
| Sunday, August 24 |
| » Lost to Phillies (34-84), 8-5 | Shibe Park (5-3) | 52-69 | |
| » Starters: Vallie Eaves vs Johnny Podgajny | Sixth | 26½ out |
| » Lost to Phillies (35-84), 7-6 | Shibe Park (5-4) | 52-70 | Lost 2 |
| » Starters: Charlie Root vs Rube Melton | Sixth | 26½ out |
| Tuesday, August 26 |
| » Defeated Phillies (35-85), 5-4 | Shibe Park (6-4) | 53-70 | |
| » Starters: Jake Mooty vs Lefty Hoerst | Sixth | 25½ out |
| » Defeated Phillies (35-86), 11-3 | Shibe Park (7-4) | 54-70 | Won 2 |
| » Starters: Paul Erickson vs Si Johnson | Sixth | 25½ out |
| Wednesday, August 27 |
| » Lost to Braves (50-72), 6-0 | Braves Field (5-4) | 54-71 | |
| » Starters: Claude Passeau vs Manny Salvo | Sixth | 26 out |
| » Defeated Braves (50-73), 6-4 | Braves Field (6-4) | 55-71 | |
| » Starters: Ken Raffensberger vs Al Javery | Sixth | 26 out |
| Thursday, August 28 |
| » Lost to Braves (51-73), 2-1 | Braves Field (6-5) | 55-72 | |
| » Starters: Vallie Eaves vs Tom Earley | Sixth | 26½ out |
| Saturday, August 30 |
| » Defeated Pirates (67-57), 4-1 | Wrigley Field (27-33) | 56-72 | |
| » Starters: Rip Sewell vs Paul Erickson | Sixth | 25½ out |
| Sunday, August 31 |
| » Lost to Pirates (68-57), 4-3 | Wrigley Field (27-34) | 56-73 | |
| » Starters: Max Butcher vs Claude Passeau | Sixth | 26½ out |
| Monday, September 1 |
| » Lost to Reds (70-54), 2-1 | Wrigley Field (27-35) | 56-74 | Lost 2 |
| » Starters: Paul Derringer vs Jake Mooty | Sixth | 27½ out |
| » Defeated Reds (70-55), 5-4 | Wrigley Field (28-35) | 57-74 | |
| » Starters: Johnny Vander Meer vs Vallie Eaves | Sixth | 27½ out |
| Tuesday, September 2 |
| » Defeated Reds (70-56), 3-1 | Wrigley Field (29-35) | 58-74 | Won 2 |
| » Starters: Junior Thompson vs Charlie Root | Sixth | 27 out |
| Thursday, September 4 |
| » Defeated Cardinals (83-46), 3-0 | Wrigley Field (30-35) | 59-74 | Won 3 |
| » Starters: Lon Warneke vs Claude Passeau | Sixth | 26 out |
| » Defeated Cardinals (83-47), 4-3 | Wrigley Field (31-35) | 60-74 | Won 4 |
| » Starters: Mort Cooper vs Paul Erickson | Sixth | 26 out |
| Saturday, September 6 |
| » Lost to Pirates (72-60), 6-4 | Forbes Field (4-6) | 60-75 | |
| » Starters: Jake Mooty vs Ken Heintzelman | Sixth | 27 out |
| » Major-league debuts: Johnny Schmitz (Cubs) |
| Sunday, September 7 |
| » Defeated Pirates (72-61), 3-1 | Forbes Field (5-6) | 61-75 | |
| » Starters: Vallie Eaves vs Johnny Lanning | Sixth | 27½ out |
| Tuesday, September 9 |
| » Major-league debuts: John Davis (Giants) |
| Wednesday, September 10 |
| » Defeated Dodgers (88-48), 5-4 | Wrigley Field (32-35) | 62-75 | Won 2 |
| » Starters: Kirby Higbe vs Claude Passeau | Sixth | 25½ out |
| » Defeated Dodgers (88-49), 5-3 | Wrigley Field (33-35) | 63-75 | Won 3 |
| » Starters: Luke Hamlin vs Paul Erickson | Sixth | 25½ out |
| Thursday, September 11 |
| » Major-league debuts: Ray Lamanno and Benny Zientara (Reds) Sid Gordon (Giants) |
| Friday, September 12 |
| » Lost to Phillies (39-96), 5-3 | Wrigley Field (33-36) | 63-76 | |
| » Starters: Tommy Hughes vs Jake Mooty | Sixth | 26 out |
| » Major-league debuts: Lennie Merullo (Cubs) |
| Saturday, September 13 |
| » Defeated Phillies (39-97), 5-4 | Wrigley Field (34-36) | 64-76 | |
| » Starters: Johnny Podgajny vs Vallie Eaves | Sixth | 26 out |
| Sunday, September 14 |
| » Lost to Braves (58-81), 6-3 | Wrigley Field (34-37) | 64-77 | |
| » Starters: Art Johnson vs Paul Erickson | Sixth | 26½ out |
| » Defeated Braves (58-82), 10-3 | Wrigley Field (35-37) | 65-77 | |
| » Starters: Johnny Hutchings vs Johnny Schmitz | Sixth | 26½ out |
| Tuesday, September 16 |
| » Lost to Braves (59-82), 8-5 | Wrigley Field (35-38) | 65-78 | |
| » Starters: Al Javery vs Claude Passeau | Sixth | 27 out |
| Wednesday, September 17 |
| » Defeated Giants (64-75), 7-3 | Wrigley Field (36-38) | 66-78 | |
| » Starters: Dave Koslo vs Vern Olsen | Sixth | 27 out |
| Thursday, September 18 |
| » Defeated Giants (64-76), 7-1 | Wrigley Field (37-38) | 67-78 | Won 2 |
| » Starters: Tom Sunkel vs Jake Mooty | Fifth | 26 out |
| Friday, September 19 |
| » Lost to Cardinals (92-52), 3-1 | Sportsman's Park III (2-6) | 67-79 | |
| » Starters: Paul Erickson vs Harry Gumbert | Fifth | 26½ out |
| Saturday, September 20 |
| » Defeated Cardinals (92-53), 7-3 | Sportsman's Park III (3-6) | 68-79 | |
| » Starters: Johnny Schmitz vs Lon Warneke | Sixth | 27 out |
| Sunday, September 21 |
| » Lost to Cardinals (93-53), 6-5 | Sportsman's Park III (3-7) | 68-80 | |
| » Starters: Claude Passeau vs Ernie White | Sixth | 28 out |
| » Lost to Cardinals (94-53), 7-0 | Sportsman's Park III (3-8) | 68-81 | Lost 2 |
| » Starters: Vern Olsen vs Howie Pollet | Sixth | 28 out |
| » Major-league debuts: Emil Kush (Cubs) |
| Tuesday, September 23 |
| » Defeated Reds (84-65), 5-1 | Crosley Field (4-5) | 69-81 | |
| » Starters: Bill Lee vs Johnny Vander Meer | Sixth | 28 out |
| Wednesday, September 24 |
| » Lost to Reds (85-65), 2-0 | Crosley Field (4-6) | 69-82 | |
| » Starters: Walt Lanfranconi vs Bucky Walters | Sixth | 29 out |
| Thursday, September 25 |
| » Lost to Reds (86-65), 6-0 | Crosley Field (4-7) | 69-83 | Lost 2 |
| » Starters: Johnny Schmitz vs Ray Starr | Sixth | 30 out |
| Saturday, September 27 |
| » Defeated Cardinals (96-56), 6-5 | Wrigley Field (38-38) | 70-83 | |
| » Starters: Howie Pollet vs Paul Erickson | Sixth | 29 out |
| Sunday, September 28 |
| » Lost to Cardinals (97-56), 3-1 | Wrigley Field (38-39) | 70-84 | |
| » Starters: Johnny Beazley vs Russ Meers | Sixth | 30 out |
| » Major-league debuts: Johnny Beazley (Cardinals) |
| Tuesday, October 14 |
| Future Cub Art Shamsky is born in St. Louis, MO. |
| Wednesday, October 29 |
| Former Cub Harvey Hendrick dies in Covington, TN at the age of 44. |
| Friday, November 7 |
| Future Cub Clarence Jone |
