| Sunday, January 7 |
| Future Senator Jim Hannan is born in Jersey City, NJ. |
| Thursday, February 15 |
| Former Senator Ray Morgan dies in Baltimore, MD at the age of 51. |
| Wednesday, March 13 |
| Former Senator Ira Flagstead dies in Olympia, WA at the age of 47. |
| Tuesday, April 16 |
| » Lost to Red Sox (1-0), 1-0 | Griffith Stadium (0-1) | 0-1 | |
| » Starters: Lefty Grove vs Dutch Leonard | Second | 1 out |
| » Major-league debuts: Jimmy Pofahl (Senators) Dom DiMaggio (Red Sox) |
| Thursday, April 18 |
| » Lost to Red Sox (2-0), 7-0 | Griffith Stadium (0-2) | 0-2 | Lost 2 |
| » Starters: Jim Bagby vs Sid Hudson | Fifth | 2 out |
| » Major-league debuts: Sid Hudson (Senators) |
| Friday, April 19 |
| » Lost to Yankees (2-1), 5-3 | Yankee Stadium (0-1) | 0-3 | Lost 3 |
| » Starters: Ken Chase vs Lefty Gomez | Eighth | 2½ out |
| Tuesday, April 23 |
| » Lost to Red Sox (4-1), 7-2 | Fenway Park (0-1) | 0-4 | Lost 4 |
| » Starters: Dutch Leonard vs Mickey Harris | Seventh | 3½ out |
| » Major-league debuts: Mickey Harris (Red Sox) |
| Wednesday, April 24 |
| » Defeated Red Sox (4-2), 9-6 | Fenway Park (1-1) | 1-4 | |
| » Starters: Joe Haynes vs Lefty Grove | Sixth | 3 out |
| Thursday, April 25 |
| » Defeated Athletics (3-4), 7-6 | Griffith Stadium (1-2) | 2-4 | Won 2 |
| » Starters: George Caster vs Joe Krakauskas | Sixth | 3 out |
| » Major-league debuts: Gil Torres (Senators) |
| Friday, April 26 |
| » Defeated Athletics (3-5), 8-6 | Griffith Stadium (2-2) | 3-4 | Won 3 |
| » Starters: Nels Potter vs Al Hollingsworth | Third | 2 out |
| Saturday, April 27 |
| » Defeated Yankees (3-4), 3-2 | Griffith Stadium (3-2) | 4-4 | Won 4 |
| » Starters: Marv Breuer vs Ken Chase | Third | 2 out |
| Sunday, April 28 |
| » Defeated Yankees (3-5), 3-2 | Griffith Stadium (4-2) | 5-4 | Won 5 |
| » Starters: Steve Sundra vs Dutch Leonard | Third | 2 out |
| Monday, April 29 |
| » Lost to Yankees (4-5), 5-4 | Griffith Stadium (4-3) | 5-5 | |
| » Starters: Spud Chandler vs Joe Krakauskas | Third | 2 out |
| Tuesday, April 30 |
| » Defeated Tigers (6-5), 9-4 | Griffith Stadium (5-3) | 6-5 | |
| » Starters: Tommy Bridges vs Joe Haynes | Third | 2 out |
| Wednesday, May 1 |
| » Lost to Tigers (7-5), 10-7 | Griffith Stadium (5-4) | 6-6 | |
| » Starters: Bobo Newsom vs Al Hollingsworth | Third | 2 out |
| Thursday, May 2 |
| » Lost to Tigers (8-5), 5-3 | Griffith Stadium (5-5) | 6-7 | Lost 2 |
| » Starters: Hal Newhouser vs Sid Hudson | Third | 2½ out |
| Saturday, May 4 |
| » Lost to Indians (9-4), 12-4 | Griffith Stadium (5-6) | 6-8 | Lost 3 |
| » Starters: Al Milnar vs Ken Chase | Fifth | 4 out |
| Sunday, May 5 |
| » Lost to Browns (6-8), 7-3 | Griffith Stadium (5-7) | 6-9 | Lost 4 |
| » Starters: Vern Kennedy vs Dutch Leonard | Fifth | 4½ out |
| Monday, May 6 |
| » Lost to Browns (7-8), 11-9 | Griffith Stadium (5-8) | 6-10 | Lost 5 |
| » Starters: Emil Bildilli vs Joe Haynes | Seventh | 5 out |
| Tuesday, May 7 |
| » Defeated Browns (7-9), 6-5 | Griffith Stadium (6-8) | 7-10 | |
| » Starters: Elden Auker vs Sid Hudson | Fifth | 5 out |
| Wednesday, May 8 |
| » Lost to White Sox (7-10), 6-3 | Griffith Stadium (6-9) | 7-11 | |
| » Starters: Eddie Smith vs Ken Chase | Sixth | 6 out |
| Thursday, May 9 |
| » Defeated White Sox (7-11), 8-4 | Griffith Stadium (7-9) | 8-11 | |
| » Starters: Thornton Lee vs Dutch Leonard | Fifth | 6 out |
| Friday, May 10 |
| » Lost to Athletics (9-11), 8-7 | Shibe Park (0-1) | 8-12 | |
| » Starters: Joe Krakauskas vs Chubby Dean | Sixth | 7 out |
| Saturday, May 11 |
| » Defeated Athletics (9-12), 9-6 | Shibe Park (1-1) | 9-12 | |
| » Starters: Sid Hudson vs Nels Potter | Fourth | 7 out |
| Sunday, May 12 |
| » Lost to Athletics (10-12), 4-2 | Shibe Park (1-2) | 9-13 | |
| » Starters: Ken Chase vs Johnny Babich | Sixth | 7 out |
| Tuesday, May 14 |
| » Defeated Tigers (12-11), 4-2 | Tiger Stadium (1-0) | 10-13 | |
| » Starters: Dutch Leonard vs Hal Newhouser | Fifth | 7 out |
| Friday, May 17 |
| » Lost to Indians (15-8), 18-1 | League Park II (0-1) | 10-14 | |
| » Starters: Sid Hudson vs Al Milnar | Fifth | 8 out |
| Saturday, May 18 |
| » Defeated Indians (15-9), 3-2 | League Park II (1-1) | 11-14 | |
| » Starters: Ken Chase vs Johnny Allen | Fifth | 7½ out |
| Sunday, May 19 |
| » Defeated White Sox (9-16), 12-10 | Comiskey Park I (1-0) | 12-14 | Won 2 |
| » Starters: Dutch Leonard vs Ted Lyons | Fourth | 7 out |
| Monday, May 20 |
| » Lost to White Sox (10-16), 5-4 | Comiskey Park I (1-1) | 12-15 | |
| » Starters: Sid Hudson vs Johnny Rigney | Fifth | 7 out |
| Tuesday, May 21 |
| » Lost to White Sox (11-16), 9-8 | Comiskey Park I (1-2) | 12-16 | Lost 2 |
| » Starters: Willis Hudlin vs Jack Knott | Fifth | 8 out |
| Wednesday, May 22 |
| » Defeated Browns (10-15), 9-2 | Sportsman's Park III (1-0) | 13-16 | |
| » Starters: Ken Chase vs Jack Kramer | Fourth | 7 out |
| Thursday, May 23 |
| » Lost to Browns (11-15), 8-7 | Sportsman's Park III (1-1) | 13-17 | |
| » Starters: Walt Masterson vs Slick Coffman | Fifth | 7½ out |
| Saturday, May 25 |
| » Defeated Athletics (12-17), 4-2 | Griffith Stadium (8-9) | 14-17 | |
| » Starters: Chubby Dean vs Dutch Leonard | Fourth | 7 out |
| Sunday, May 26 |
| » Defeated Athletics (12-18), 4-3 | Griffith Stadium (9-9) | 15-17 | Won 2 |
| » Starters: George Caster vs Willis Hudlin | Fourth | 6 out |
| Monday, May 27 |
| » Lost to Yankees (13-17), 5-0 | Yankee Stadium (0-2) | 15-18 | |
| » Starters: Ken Chase vs Spud Chandler | Fifth | 6½ out |
| Tuesday, May 28 |
| » Lost to Yankees (14-17), 12-4 | Yankee Stadium (0-3) | 15-19 | Lost 2 |
| » Starters: Joe Haynes vs Marius Russo | Seventh | 8 out |
| » Lost to Yankees (15-17), 3-1 | Yankee Stadium (0-4) | 15-20 | Lost 3 |
| » Starters: Rene Monteagudo vs Marv Breuer | Seventh | 8 out |
| Wednesday, May 29 |
| » Lost to Yankees (16-17), 2-1 | Yankee Stadium (0-5) | 15-21 | Lost 4 |
| » Starters: Dutch Leonard vs Atley Donald | Seventh | 9 out |
| Thursday, May 30 |
| » Lost to Athletics (13-20), 7-6 | Shibe Park (1-3) | 15-22 | Lost 5 |
| » Starters: Ken Chase vs Chubby Dean | Sixth | 9 out |
| » Defeated Athletics (13-21), 14-2 | Shibe Park (2-3) | 16-22 | |
| » Starters: Walt Masterson vs George Caster | Sixth | 9 out |
| Saturday, June 1 |
| » Lost to Tigers (21-15), 12-3 | Griffith Stadium (9-10) | 16-23 | |
| » Starters: Bobo Newsom vs Willis Hudlin | Sixth | 10 out |
| Sunday, June 2 |
| » Lost to Tigers (22-15), 8-6 | Griffith Stadium (9-11) | 16-24 | Lost 2 |
| » Starters: Dizzy Trout vs Rene Monteagudo | Seventh | 10½ out |
| Monday, June 3 |
| » Defeated Tigers (22-16), 9-3 | Griffith Stadium (10-11) | 17-24 | |
| » Starters: Johnny Gorsica vs Dutch Leonard | Sixth | 9½ out |
| Tuesday, June 4 |
| » Defeated Indians (25-16), 7-2 | Griffith Stadium (11-11) | 18-24 | Won 2 |
| » Starters: Mel Harder vs Ken Chase | Sixth | 9 out |
| » Lost to Indians (26-16), 3-2 | Griffith Stadium (11-12) | 18-25 | |
| » Starters: Al Smith vs Joe Haynes | Sixth | 9 out |
| Wednesday, June 5 |
| » Defeated Indians (26-17), 6-1 | Griffith Stadium (12-12) | 19-25 | |
| » Starters: Joe Dobson vs Walt Masterson | Sixth | 8 out |
| Thursday, June 6 |
| » Lost to Indians (27-17), 5-4 | Griffith Stadium (12-13) | 19-26 | |
| » Starters: Johnny Allen vs Sid Hudson | Sixth | 9 out |
| Friday, June 7 |
| » Defeated White Sox (20-25), 3-2 | Griffith Stadium (13-13) | 20-26 | |
| » Starters: Jack Knott vs Dutch Leonard | Sixth | 8 out |
| Saturday, June 8 |
| » Lost to White Sox (21-25), 12-6 | Griffith Stadium (13-14) | 20-27 | |
| » Starters: Bill Dietrich vs Ken Chase | Sixth | 8 out |
| Sunday, June 9 |
| » Lost to White Sox (22-25), 4-3 | Griffith Stadium (13-15) | 20-28 | Lost 2 |
| » Starters: Ted Lyons vs Walt Masterson | Sixth | 8½ out |
| Monday, June 10 |
| » Lost to Browns (20-27), 7-4 | Griffith Stadium (13-16) | 20-29 | Lost 3 |
| » Starters: Jack Kramer vs Sid Hudson | Seventh | 9 out |
| Tuesday, June 11 |
| » Lost to Browns (21-27), 5-2 | Griffith Stadium (13-17) | 20-30 | Lost 4 |
| » Starters: Vern Kennedy vs Dutch Leonard | Seventh | 10 out |
| Wednesday, June 12 |
| » Defeated Browns (21-28), 3-2 | Griffith Stadium (14-17) | 21-30 | |
| » Starters: Elden Auker vs Ken Chase | Seventh | 10 out |
| Friday, June 14 |
| » Lost to Tigers (27-20), 10-1 | Tiger Stadium (1-1) | 21-31 | |
| » Starters: Walt Masterson vs Hal Newhouser | Seventh | 11 out |
| Saturday, June 15 |
| » Lost to Tigers (28-20), 11-1 | Tiger Stadium (1-2) | 21-32 | Lost 2 |
| » Starters: Sid Hudson vs Bobo Newsom | Eighth | 12½ out |
| » Lost to Tigers (29-20), 8-0 | Tiger Stadium (1-3) | 21-33 | Lost 3 |
| » Starters: Joe Haynes vs Johnny Gorsica | Eighth | 12½ out |
| Sunday, June 16 |
| » Lost to Tigers (30-20), 8-7 | Tiger Stadium (1-4) | 21-34 | Lost 4 |
| » Starters: Willis Hudlin vs Tommy Bridges | Seventh | 14 out |
| Tuesday, June 18 |
| » Lost to Indians (33-22), 2-1 | Cleveland Stadium (0-1) | 21-35 | Lost 5 |
| » Starters: Dutch Leonard vs Al Smith | Seventh | 14 out |
| Wednesday, June 19 |
| » Lost to Indians (34-22), 4-1 | League Park II (1-2) | 21-36 | Lost 6 |
| » Starters: Ken Chase vs Johnny Allen | Seventh | 14 out |
| Thursday, June 20 |
| » Lost to Indians (35-22), 12-1 | League Park II (1-3) | 21-37 | Lost 7 |
| » Starters: Walt Masterson vs Bob Feller | Eighth | 14½ out |
| Friday, June 21 |
| » Defeated Browns (27-31), 1-0 | Sportsman's Park III (2-1) | 22-37 | |
| » Starters: Sid Hudson vs Vern Kennedy | Eighth | 14½ out |
| Saturday, June 22 |
| » Defeated Browns (27-32), 11-10 | Sportsman's Park III (3-1) | 23-37 | Won 2 |
| » Starters: Willis Hudlin vs Elden Auker | Eighth | 14½ out |
| Sunday, June 23 |
| » Defeated Browns (27-33), 12-5 | Sportsman's Park III (4-1) | 24-37 | Won 3 |
| » Starters: Dutch Leonard vs Roxie Lawson | Eighth | 14½ out |
| » Lost to Browns (28-33), 3-2 | Sportsman's Park III (4-2) | 24-38 | |
| » Starters: Ken Chase vs Bob Harris | Eighth | 14½ out |
| Tuesday, June 25 |
| » Defeated White Sox (26-32), 7-6 | Comiskey Park I (2-2) | 25-38 | |
| » Starters: Sid Hudson vs Johnny Rigney | Seventh | 15 out |
| Wednesday, June 26 |
| » Lost to White Sox (27-32), 7-6 | Comiskey Park I (2-3) | 25-39 | |
| » Starters: Walt Masterson vs Eddie Smith | Eighth | 15 out |
| Friday, June 28 |
| » Defeated Red Sox (34-25), 4-3 | Fenway Park (2-1) | 26-39 | |
| » Starters: Dutch Leonard vs Denny Galehouse | Seventh | 14½ out |
| Saturday, June 29 |
| » Defeated Red Sox (34-26), 9-7 | Fenway Park (3-1) | 27-39 | Won 2 |
| » Starters: Sid Hudson vs Jack Wilson | Seventh | 14½ out |
| Sunday, June 30 |
| » Lost to Red Sox (35-26), 6-5 | Fenway Park (3-2) | 27-40 | |
| » Starters: Willis Hudlin vs Lefty Grove | Seventh | 15½ out |
| » Lost to Red Sox (36-26), 5-4 | Fenway Park (3-3) | 27-41 | Lost 2 |
| » Starters: Walt Masterson vs Herb Hash | Seventh | 15½ out |
| Monday, July 1 |
| » Lost to Yankees (33-32), 8-4 | Griffith Stadium (14-18) | 27-42 | Lost 3 |
| » Starters: Red Ruffing vs Ken Chase | Eighth | 15½ out |
| Tuesday, July 2 |
| » Lost to Yankees (34-32), 6-2 | Griffith Stadium (14-19) | 27-43 | Lost 4 |
| » Starters: Lefty Gomez vs Dutch Leonard | Eighth | 15½ out |
| Thursday, July 4 |
| » Defeated Athletics (26-41), 5-1 | Griffith Stadium (15-19) | 28-43 | |
| » Starters: George Caster vs Sid Hudson | Seventh | 15 out |
| » Defeated Athletics (26-42), 9-5 | Griffith Stadium (16-19) | 29-43 | Won 2 |
| » Starters: Bill Beckmann vs Joe Krakauskas | Seventh | 15 out |
| Friday, July 5 |
| » Lost to Red Sox (39-30), 9-4 | Griffith Stadium (16-20) | 29-44 | |
| » Starters: Jim Bagby vs Walt Masterson | Seventh | 15½ out |
| Saturday, July 6 |
| » Lost to Red Sox (40-30), 5-3 | Griffith Stadium (16-21) | 29-45 | Lost 2 |
| » Starters: Denny Galehouse vs Ken Chase | Eighth | 16½ out |
| Sunday, July 7 |
| » Lost to Red Sox (41-30), 7-1 | Griffith Stadium (16-22) | 29-46 | Lost 3 |
| » Starters: Lefty Grove vs Dutch Leonard | Eighth | 16½ out |
| » Defeated Red Sox (41-31), 7-4 | Griffith Stadium (17-22) | 30-46 | |
| » Starters: Alex Mustaikis vs Rene Monteagudo | Eighth | 16½ out |
| Thursday, July 11 |
| » Defeated Tigers (44-28), 7-3 | Griffith Stadium (18-22) | 31-46 | Won 2 |
| » Starters: Hal Newhouser vs Sid Hudson | Seventh | 16 out |
| Saturday, July 13 |
| » Lost to Tigers (45-28), 4-3 | Griffith Stadium (18-23) | 31-47 | |
| » Starters: Tommy Bridges vs Dutch Leonard | Seventh | 18 out |
| » Lost to Tigers (46-28), 4-0 | Griffith Stadium (18-24) | 31-48 | Lost 2 |
| » Starters: Bobo Newsom vs Walt Masterson | Seventh | 18 out |
| Sunday, July 14 |
| » Defeated Indians (48-30), 6-5 | Griffith Stadium (19-24) | 32-48 | |
| » Starters: Al Smith vs Ken Chase | Eighth | 17 out |
| Monday, July 15 |
| » Defeated Indians (48-31), 8-6 | Griffith Stadium (20-24) | 33-48 | Won 2 |
| » Starters: Al Milnar vs Sid Hudson | Sixth | 16 out |
| Tuesday, July 16 |
| » Defeated Indians (48-32), 11-8 | Griffith Stadium (21-24) | 34-48 | Won 3 |
| » Starters: Harry Eisenstat vs Joe Krakauskas | Sixth | 15 out |
| Wednesday, July 17 |
| » Defeated White Sox (37-40), 5-2 | Griffith Stadium (22-24) | 35-48 | Won 4 |
| » Starters: Bill Dietrich vs Dutch Leonard | Fifth | 14 out |
| Thursday, July 18 |
| » Defeated White Sox (37-41), 5-4 | Griffith Stadium (23-24) | 36-48 | Won 5 |
| » Starters: Jack Knott vs Ken Chase | Sixth | 13½ out |
| Friday, July 19 |
| » Lost to White Sox (38-41), 9-1 | Griffith Stadium (23-25) | 36-49 | |
| » Starters: Thornton Lee vs Walt Masterson | Sixth | 14½ out |
| Saturday, July 20 |
| » Lost to Browns (35-51), 4-1 | Griffith Stadium (23-26) | 36-50 | Lost 2 |
| » Starters: Johnny Niggeling vs Sid Hudson | Sixth | 15½ out |
| Sunday, July 21 |
| » Lost to Browns (36-51), 8-4 | Griffith Stadium (23-27) | 36-51 | Lost 3 |
| » Starters: Elden Auker vs Dutch Leonard | Sixth | 16½ out |
| » Defeated Browns (36-52), 5-4 | Griffith Stadium (24-27) | 37-51 | |
| » Starters: Bob Harris vs Rene Monteagudo | Sixth | 16½ out |
| Tuesday, July 23 |
| » Defeated Tigers (52-34), 6-3 | Tiger Stadium (2-4) | 38-51 | Won 2 |
| » Starters: Ken Chase vs Johnny Gorsica | Sixth | 15½ out |
| Future Senator Hank Allen is born in Wampum, PA. |
| Wednesday, July 24 |
| » Lost to Tigers (53-34), 7-5 | Tiger Stadium (2-5) | 38-52 | |
| » Starters: Sid Hudson vs Fred Hutchinson | Sixth | 16½ out |
| Thursday, July 25 |
| » Lost to Tigers (54-34), 5-2 | Tiger Stadium (2-6) | 38-53 | Lost 2 |
| » Starters: Dutch Leonard vs Hal Newhouser | Sixth | 17½ out |
| Friday, July 26 |
| » Lost to Indians (54-36), 13-2 | League Park II (1-4) | 38-54 | Lost 3 |
| » Starters: Rene Monteagudo vs Bob Feller | Sixth | 17½ out |
| Saturday, July 27 |
| » Defeated Indians (54-37), 7-1 | League Park II (2-4) | 39-54 | |
| » Starters: Ken Chase vs Joe Dobson | Sixth | 18 out |
| Sunday, July 28 |
| » Lost to Indians (55-37), 6-3 | Cleveland Stadium (0-2) | 39-55 | |
| » Starters: Walt Masterson vs Al Milnar | Sixth | 17½ out |
| » Defeated Indians (55-38), 9-1 | Cleveland Stadium (1-2) | 40-55 | |
| » Starters: Sid Hudson vs Al Smith | Sixth | 17½ out |
| Tuesday, July 30 |
| » Defeated Browns (39-57), 4-0 | Sportsman's Park III (5-2) | 41-55 | Won 2 |
| » Starters: Dutch Leonard vs John Whitehead | Fifth | 16 out |
| Wednesday, July 31 |
| » Defeated Browns (39-58), 13-5 | Sportsman's Park III (6-2) | 42-55 | Won 3 |
| » Starters: Ken Chase vs Vern Kennedy | Fifth | 16 out |
| Friday, August 2 |
| » Lost to White Sox (49-44), 10-2 | Comiskey Park I (2-4) | 42-56 | |
| » Starters: Sid Hudson vs Thornton Lee | Sixth | 16½ out |
| Saturday, August 3 |
| » Lost to White Sox (50-44), 7-6 | Comiskey Park I (2-5) | 42-57 | Lost 2 |
| » Starters: Rene Monteagudo vs Jack Knott | Sixth | 18 out |
| Sunday, August 4 |
| » Defeated White Sox (50-45), 4-3 | Comiskey Park I (3-5) | 43-57 | |
| » Starters: Dutch Leonard vs Ted Lyons | Sixth | 16½ out |
| » Defeated White Sox (50-46), 1-0 | Comiskey Park I (4-5) | 44-57 | Won 2 |
| » Starters: Ken Chase vs Johnny Rigney | Sixth | 16½ out |
| Monday, August 5 |
| » Major-league debuts: Ernie Bonham (Yankees) |
| Tuesday, August 6 |
| » Defeated Athletics (39-61), 11-0 | Griffith Stadium (25-27) | 45-57 | Won 3 |
| » Starters: Buck Ross vs Sid Hudson | Sixth | 16½ out |
| Thursday, August 8 |
| » Lost to Athletics (40-61), 6-4 | Griffith Stadium (25-28) | 45-58 | |
| » Starters: George Caster vs Walt Masterson | Sixth | 17½ out |
| Friday, August 9 |
| » Defeated Red Sox (57-48), 6-5 | Griffith Stadium (26-28) | 46-58 | |
| » Starters: Fritz Ostermueller vs Dutch Leonard | Sixth | 16½ out |
| Saturday, August 10 |
| » Lost to Red Sox (58-48), 3-0 | Griffith Stadium (26-29) | 46-59 | |
| » Starters: Earl Johnson vs Ken Chase | Sixth | 17½ out |
| Sunday, August 11 |
| » Defeated Red Sox (58-49), 2-1 | Griffith Stadium (27-29) | 47-59 | |
| » Starters: Lefty Grove vs Sid Hudson | Fifth | 16 out |
| Tuesday, August 13 |
| » Lost to Athletics (41-64), 6-3 | Shibe Park (2-4) | 47-60 | |
| » Starters: Dutch Leonard vs Johnny Babich | Sixth | 17½ out |
| Wednesday, August 14 |
| » Defeated Athletics (41-65), 5-3 | Shibe Park (3-4) | 48-60 | |
| » Starters: Ken Chase vs Nels Potter | Sixth | 17½ out |
| Thursday, August 15 |
| » Defeated Athletics (41-66), 9-4 | Shibe Park (4-4) | 49-60 | Won 2 |
| » Starters: Sid Hudson vs George Caster | Sixth | 18 out |
| » Lost to Athletics (42-66), 6-5 | Shibe Park (4-5) | 49-61 | |
| » Starters: Walt Masterson vs Bill Beckmann | Sixth | 18 out |
| Friday, August 16 |
| » Lost to Red Sox (60-52), 7-6 | Fenway Park (3-4) | 49-62 | Lost 2 |
| » Starters: Rene Monteagudo vs Fritz Ostermueller | Sixth | 19 out |
| Saturday, August 17 |
| » Lost to Red Sox (61-52), 12-9 | Fenway Park (3-5) | 49-63 | Lost 3 |
| » Starters: Dutch Leonard vs Yank Terry | Sixth | 19 out |
| Sunday, August 18 |
| » Lost to Red Sox (62-52), 4-2 | Fenway Park (3-6) | 49-64 | Lost 4 |
| » Starters: Ken Chase vs Earl Johnson | Sixth | 19½ out |
| Tuesday, August 20 |
| » Lost to Browns (48-69), 6-3 | Griffith Stadium (27-30) | 49-65 | Lost 5 |
| » Starters: Elden Auker vs Sid Hudson | Sixth | 20 out |
| Wednesday, August 21 |
| » Defeated Browns (48-70), 3-0 | Griffith Stadium (28-30) | 50-65 | |
| » Starters: Lefty Mills vs Dutch Leonard | Fifth | 20 out |
| Friday, August 23 |
| » Defeated White Sox (60-55), 3-2 | Griffith Stadium (29-30) | 51-65 | Won 2 |
| » Starters: Bill Dietrich vs Ken Chase | Sixth | 18½ out |
| Saturday, August 24 |
| » Lost to White Sox (61-55), 4-2 | Griffith Stadium (29-31) | 51-66 | |
| » Starters: Jack Knott vs Walt Masterson | Sixth | 19 out |
| » Lost to White Sox (62-55), 2-1 | Griffith Stadium (29-32) | 51-67 | Lost 2 |
| » Starters: Eddie Smith vs Joe Krakauskas | Sixth | 19 out |
| » Major-league debuts: Jack Sanford (Senators) |
| Sunday, August 25 |
| » Defeated Indians (71-50), 5-4 | Griffith Stadium (30-32) | 52-67 | |
| » Starters: Johnny Allen vs Sid Hudson | Sixth | 18 out |
| Monday, August 26 |
| » Lost to Indians (72-50), 4-3 | Griffith Stadium (30-33) | 52-68 | |
| » Starters: Mel Harder vs Dutch Leonard | Sixth | 19 out |
| Thursday, August 29 |
| » Lost to Tigers (70-53), 3-2 | Griffith Stadium (30-34) | 52-69 | Lost 2 |
| » Starters: Schoolboy Rowe vs Ken Chase | Sixth | 20 out |
| » Lost to Tigers (71-53), 6-0 | Griffith Stadium (30-35) | 52-70 | Lost 3 |
| » Starters: Bobo Newsom vs Sid Hudson | Sixth | 20 out |
| Saturday, August 31 |
| » Lost to Yankees (68-55), 7-1 | Yankee Stadium (0-6) | 52-71 | Lost 4 |
| » Starters: Joe Krakauskas vs Atley Donald | Sixth | 21½ out |
| Sunday, September 1 |
| » Lost to Yankees (69-55), 3-2 | Yankee Stadium (0-7) | 52-72 | Lost 5 |
| » Starters: Dutch Leonard vs Red Ruffing | Sixth | 23 out |
| » Lost to Yankees (70-55), 3-0 | Yankee Stadium (0-8) | 52-73 | Lost 6 |
| » Starters: Walt Masterson vs Tiny Bonham | Sixth | 23 out |
| Monday, September 2 |
| » Defeated Red Sox (69-59), 1-0 | Griffith Stadium (31-35) | 53-73 | |
| » Starters: Lefty Grove vs Sid Hudson | Sixth | 21 out |
| » Defeated Red Sox (69-60), 5-4 | Griffith Stadium (32-35) | 54-73 | Won 2 |
| » Starters: Bill Fleming vs Ken Chase | Sixth | 21 out |
| Wednesday, September 4 |
| » Defeated Yankees (71-57), 6-5 | Griffith Stadium (33-35) | 55-73 | Won 3 |
| » Starters: Steve Sundra vs Joe Krakauskas | Sixth | 20 out |
| Thursday, September 5 |
| » Lost to Yankees (72-57), 2-1 | Griffith Stadium (33-36) | 55-74 | |
| » Starters: Tiny Bonham vs Dutch Leonard | Sixth | 20½ out |
| » Lost to Yankees (73-57), 8-1 | Griffith Stadium (33-37) | 55-75 | Lost 2 |
| » Starters: Atley Donald vs Walt Masterson | Sixth | 20½ out |
| Friday, September 6 |
| » Defeated Yankees (73-58), 3-1 | Griffith Stadium (34-37) | 56-75 | |
| » Starters: Red Ruffing vs Ken Chase | Sixth | 19½ out |
| Saturday, September 7 |
| » Lost to Athletics (48-77), 8-5 | Griffith Stadium (34-38) | 56-76 | |
| » Starters: Johnny Babich vs Joe Haynes | Sixth | 19½ out |
| Sunday, September 8 |
| » Defeated Athletics (48-78), 7-6 | Griffith Stadium (35-38) | 57-76 | |
| » Starters: Porter Vaughan vs Sid Hudson | Sixth | 20 out |
| » Lost to Athletics (49-78), 4-0 | Griffith Stadium (35-39) | 57-77 | |
| » Starters: Bill Beckmann vs Red Anderson | Sixth | 20 out |
| » Major-league debuts: Jim Mallory and Sherry Robertson (Senators) |
| Tuesday, September 10 |
| » Defeated White Sox (71-64), 5-2 | Comiskey Park I (5-5) | 58-77 | |
| » Starters: Ken Chase vs Jack Knott | Sixth | 19 out |
| Future Senator Bob Chance is born in Statesboro, GA. Former Senator Bill Shipke dies in Omaha, NE at the age of 58 |
| Wednesday, September 11 |
| » Lost to White Sox (72-64), 7-4 | Comiskey Park I (5-6) | 58-78 | |
| » Starters: Dutch Leonard vs Johnny Rigney | Sixth | 20 out |
| Thursday, September 12 |
| » Defeated Browns (56-82), 7-2 | Sportsman's Park III (7-2) | 59-78 | |
| » Starters: Red Anderson vs Vern Kennedy | Sixth | 20 out |
| Friday, September 13 |
| » Lost to Browns (57-82), 7-3 | Sportsman's Park III (7-3) | 59-79 | |
| » Starters: Sid Hudson vs Bill Trotter | Sixth | 21 out |
| Saturday, September 14 |
| » Lost to Browns (58-82), 5-2 | Sportsman's Park III (7-4) | 59-80 | Lost 2 |
| » Starters: Ken Chase vs Bob Harris | Sixth | 21 out |
| Sunday, September 15 |
| » Defeated Tigers (80-60), 6-1 | Tiger Stadium (3-6) | 60-80 | |
| » Starters: Dutch Leonard vs Fred Hutchinson | Sixth | 21 out |
| Monday, September 16 |
| » Lost to Tigers (81-60), 9-2 | Tiger Stadium (3-7) | 60-81 | |
| » Starters: Joe Krakauskas vs Bobo Newsom | Seventh | 21½ out |
| Tuesday, September 17 |
| » Lost to Tigers (82-60), 6-3 | Tiger Stadium (3-8) | 60-82 | Lost 2 |
| » Starters: Walt Masterson vs Schoolboy Rowe | Seventh | 22 out |
| Future Senator Cisco Carlos is born in Monrovia, CA. |
| Wednesday, September 18 |
| » Lost to Indians (83-61), 3-1 | Cleveland Stadium (1-3) | 60-83 | Lost 3 |
| » Starters: Ken Chase vs Johnny Allen | Seventh | 23½ out |
| » Lost to Indians (84-61), 2-1 | Cleveland Stadium (1-4) | 60-84 | Lost 4 |
| » Starters: Sid Hudson vs Bob Feller | Seventh | 23½ out |
| Thursday, September 19 |
| » Lost to Indians (85-61), 3-1 | Cleveland Stadium (1-5) | 60-85 | Lost 5 |
| » Starters: Dutch Leonard vs Al Smith | Sixth | 24½ out |
| Sunday, September 22 |
| » Defeated Athletics (53-91), 5-4 | Shibe Park (5-5) | 61-85 | |
| » Starters: Sid Hudson vs Johnny Babich | Seventh | 24 out |
| » Defeated Athletics (53-92), 5-2 | Shibe Park (6-5) | 62-85 | Won 2 |
| » Starters: Ken Chase vs Phil Marchildon | Seventh | 24 out |
| Tuesday, September 24 |
| » Lost to Yankees (83-65), 6-5 | Yankee Stadium (0-9) | 62-86 | |
| » Starters: Dutch Leonard vs Atley Donald | Seventh | 25 out |
| » Lost to Yankees (84-65), 9-4 | Yankee Stadium (0-10) | 62-87 | Lost 2 |
| » Starters: Joe Krakauskas vs Spud Chandler | Seventh | 25 out |
| Thursday, September 26 |
| » Defeated Red Sox (77-72), 6-5 | Fenway Park (4-6) | 63-87 | |
| » Starters: Walt Masterson vs Jim Bagby | Seventh | 25½ out |
| Friday, September 27 |
| » Lost to Red Sox (78-72), 24-4 | Fenway Park (4-7) | 63-88 | |
| » Starters: Rene Monteagudo vs Fritz Ostermueller | Seventh | 26½ out |
| Saturday, September 28 |
| » Defeated Yankees (86-67), 4-3 | Griffith Stadium (36-39) | 64-88 | |
| » Starters: Marv Breuer vs Sid Hudson | Seventh | 26 out |
| » Lost to Yankees (87-67), 7-1 | Griffith Stadium (36-40) | 64-89 | |
| » Starters: Atley Donald vs Ken Chase | Seventh | 26 out |
| Sunday, September 29 |
| » Lost to Yankees (88-67), 4-3 | Griffith Stadium (36-41) | 64-90 | Lost 2 |
| » Starters: Tiny Bonham vs Dutch Leonard | Seventh | 26 out |
| Saturday, November 16 |
| Future Senator Buster Narum is born in Philadelphia, PA. |
| Thursday, November 21 |
| Future Senator Tom McCraw is born in Malvern, AR. |
| Sunday, December 8 |
| Future Senator Brant Alyea is born in Passaic, NJ. |
| Thursday, December 12 |
| Future Senator Tom Brown is born in Laureldale, PA. |
Game information provided by Retrosheet (www.retrosheet.org) |